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Federico Bernal, Ph.D. - Publications

Affiliations: 
Laboratory of Protein Dynamics and Signaling National Cancer Institute, Rockville, MD, United States 
Area:
Cancer Chemical Biology
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Paquette AR, Payne SR, McKay GA, Brazeau-Henrie JT, Darnowski MG, Kammili A, Bernal F, Mah TF, Gruenheid S, Nguyen D, Boddy CN. RpoN-Based stapled peptides with improved DNA binding suppress virulence. Rsc Medicinal Chemistry. 13: 445-455. PMID 35647551 DOI: 10.1039/d1md00371b  0.562
2018 Payne SR, Pau DI, Whiting AL, Kim YJ, Pharoah BM, Moi C, Boddy CN, Bernal F. Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled Peptide. Cell Chemical Biology. PMID 29887265 DOI: 10.1016/J.Chembiol.2018.05.007  0.599
2017 Aguilar-Alonso F, Whiting AL, Kim YJ, Bernal F. Biophysical and biological evaluation of optimized stapled peptide inhibitors of the linear ubiquitin chain assembly complex (LUBAC). Bioorganic & Medicinal Chemistry. PMID 29246782 DOI: 10.1016/J.Bmc.2017.11.047  0.338
2017 Whiting AL, Aguilar-Alonso F, Mitala JJ, Bernal F. Abstract 5235: Affecting activity of the linear ubiquitin chain assembly complex (LUBAC) with stapled alpha-helical peptides Cancer Research. 77: 5235-5235. DOI: 10.1158/1538-7445.Am2017-5235  0.33
2016 Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. Acs Chemical Biology. PMID 27643505 DOI: 10.1021/Acschembio.6B00465  0.333
2014 Bernal F, Katz SG. Synthesis of stabilized alpha-helical peptides. Methods in Molecular Biology (Clifton, N.J.). 1176: 107-14. PMID 25030922 DOI: 10.1007/978-1-4939-0992-6_9  0.353
2014 Morrison BL, Whiting AL, Bernal F. Abstract 4071: SAH-p53-mediated inhibition of cell migration via alteration of actin dynamics Cancer Research. 74: 4071-4071. DOI: 10.1158/1538-7445.Am2014-4071  0.361
2014 Whiting AL, Mitala JJ, Headley KM, Reilly J, Morrison BL, Murray KA, Bernal F. Abstract 3234: Covalent capture of protein binding partners using an azide-tagged, photo-reactive stapled alpha helical p53 peptide Cancer Research. 74: 3234-3234. DOI: 10.1158/1538-7445.Am2014-3234  0.39
2013 Morrison BL, Russell E, Mitala J, Bernal F. Abstract 839: An uncharacterized mechanism of cell death independent of p53 mutation status. Cancer Research. 73: 839-839. DOI: 10.1158/1538-7445.Am2013-839  0.343
2013 Felsenstein KM, Headley KM, Murray KA, Russell EA, Bernal F. Abstract 2223: Identification of novel protein modulators of p53 family function using photochemical crosslinking of stapled peptides. Cancer Research. 73: 2223-2223. DOI: 10.1158/1538-7445.Am2013-2223  0.395
2012 Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, ... ... Bernal F, et al. MDM4 is a key therapeutic target in cutaneous melanoma. Nature Medicine. 18: 1239-47. PMID 22820643 DOI: 10.1038/Nm.2863  0.335
2012 Russell EA, Gembarska A, Marine J, Bernal F. Abstract 4730: Inhibition of the p53-HDMX interaction sensitizes melanoma to chemotherapy Cancer Research. 72: 4730-4730. DOI: 10.1158/1538-7445.Am2012-4730  0.348
2012 Morrison BL, Bernal F. Abstract 4329: Modulation of metastatic behavior in breast cancers harboring p53 mutations Cancer Research. 72: 4329-4329. DOI: 10.1158/1538-7445.Am2012-4329  0.332
2010 Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 18: 411-22. PMID 21075307 DOI: 10.1016/J.Ccr.2010.10.024  0.36
2009 Bernal F, Wade M, Wahl GM, Walensky LD. Abstract C174: Therapeutic reactivation of p53 through dual targeting of HDM2 and HDMX with a stapled p53 peptide Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C174  0.406
2008 Bird GH, Bernal F, Pitter K, Walensky LD. Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. Methods in Enzymology. 446: 369-86. PMID 18603134 DOI: 10.1016/S0076-6879(08)01622-4  0.335
2008 Bernal F, Wade M, Silverstein AM, Verdine GL, Wahl GM, Walensky LD. A Stapled p53 Helix Targets HDMX to Overcome Nutlin-3 Resistance and Reactivate the p53 Tumor Suppressor Pathway in Cancer Blood. 112: 2645-2645. DOI: 10.1182/Blood.V112.11.2645.2645  0.574
2007 Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. Journal of the American Chemical Society. 129: 2456-7. PMID 17284038 DOI: 10.1021/Ja0693587  0.578
2007 Bernal F, Tyler AF, Korsmeyer SJ, Walensky aLD, Verdine GL. Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide [J. Am. Chem. Soc. 2007, 129, 2456−2457]. Journal of the American Chemical Society. 129: 5298-5298. DOI: 10.1021/Ja076886P  0.55
2006 Nicolaou KC, Chen DY, Li Y, Uesaka N, Petrovic G, Koftis TV, Bernal F, Frederick MO, Govindasamy M, Ling T, Pihko PM, Tang W, Vyskocil S. Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product. Journal of the American Chemical Society. 128: 2258-67. PMID 16478179 DOI: 10.1021/Ja054748Z  0.708
2006 Nicolaou KC, Pihko PM, Bernal F, Frederick MO, Qian W, Uesaka N, Diedrichs N, Hinrichs J, Koftis TV, Loizidou E, Petrovic G, Rodriquez M, Sarlah D, Zou N. Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure. Journal of the American Chemical Society. 128: 2244-57. PMID 16478178 DOI: 10.1021/Ja0547477  0.675
2006 Bernal F, Walensky LD, Tyler AF, Korsmeyer SJ, Verdine GL. Selective Targeting of the p53-hDM2 Interaction Using Hydrocarbon-Stapled p53 Peptides. Blood. 108: 525-525. DOI: 10.1182/Blood.V108.11.525.525  0.586
2003 Nicolaou KC, Li Y, Uesaka N, Koftis TV, Vyskocil S, Ling T, Govindasamy M, Qian W, Bernal F, Chen DY. Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments. Angewandte Chemie (International Ed. in English). 42: 3643-8. PMID 12916036 DOI: 10.1002/Anie.200351825  0.577
2001 Nicolaou KC, Qian W, Bernal F, Uesaka N, Pihko PM, Hinrichs J. Synthesis of the ABCD Ring System of Azaspiracid. Angewandte Chemie (International Ed. in English). 40: 4068-4071. PMID 29712267 DOI: 10.1002/1521-3773(20011105)40:21<4068::AID-ANIE4068>3.0.CO;2-Y  0.619
2001 Nicolaou KC, Qian W, Bernal F, Uesaka N, Pihko PM, Hinrichs J. Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 4068-4071. PMID 12404495 DOI: 10.1002/1521-3773(20011105)40:21<4068::AID-ANIE4068>3.0.CO;2-Y  0.618
2001 Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 1573. PMID 11353466 DOI: 10.1002/1521-3773(20010504)40:9<1573::AID-ANIE15733>3.0.CO;2-D  0.629
2001 Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 1262-1265. PMID 11301444 DOI: 10.1002/1521-3773(20010401)40:7<1262::Aid-Anie1262>3.0.Co;2-9  0.672
1998 Nicolaou KC, Shi GQ, Namoto K, Bernal F. Synthesis of N-heterocycles via lactam-derived ketene aminal phosphates. Asymmetric synthesis of cyclic amino acids Chemical Communications. 1757-1758.  0.659
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