| Year |
Citation |
Score |
| 2020 |
Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Understanding and Improving the Membrane Permeability of VH032-Based PROTACs. Acs Medicinal Chemistry Letters. 11: 1732-1738. PMID 32939229 DOI: 10.1021/Acsmedchemlett.0C00265 |
0.326 |
|
| 2018 |
Runcie AC, Zengerle M, Chan KH, Testa A, van Beurden L, Baud MGJ, Epemolu O, Ellis LCJ, Read KD, Coulthard V, Brien A, Ciulli A. Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition. Chemical Science. 9: 2452-2468. PMID 29732121 DOI: 10.1039/C7Sc02536J |
0.403 |
|
| 2017 |
Chan KH, Zengerle M, Testa A, Ciulli A. Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds. Journal of Medicinal Chemistry. PMID 28595007 DOI: 10.1021/Acs.Jmedchem.6B01912 |
0.436 |
|
| 2017 |
Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nature Chemical Biology. PMID 28288108 DOI: 10.1038/Nchembio.2329 |
0.402 |
|
| 2016 |
Runcie AC, Chan KH, Zengerle M, Ciulli A. Chemical genetics approaches for selective intervention in epigenetics. Current Opinion in Chemical Biology. 33: 186-194. PMID 27423045 DOI: 10.1016/J.Cbpa.2016.06.031 |
0.354 |
|
| 2016 |
Baud MGJ, Lin-Shiao E, Zengerle M, Tallant C, Ciulli A. New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. Journal of Medicinal Chemistry. 59: 1492-1500. PMID 26367539 DOI: 10.1021/Acs.Jmedchem.5B01135 |
0.389 |
|
| 2015 |
Zengerle M, Chan KH, Ciulli A. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. Acs Chemical Biology. PMID 26035625 DOI: 10.1021/Acschembio.5B00216 |
0.406 |
|
| 2014 |
Baud MG, Lin-Shiao E, Cardote T, Tallant C, Pschibul A, Chan KH, Zengerle M, Garcia JR, Kwan TT, Ferguson FM, Ciulli A. Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science (New York, N.Y.). 346: 638-41. PMID 25323695 DOI: 10.1126/Science.1249830 |
0.4 |
|
| 2014 |
Bierwisch A, Zengerle M, Thiermann H, Kubik S, Worek F. Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin--an in vitro structure-activity study. Toxicology Letters. 224: 209-14. PMID 24185128 DOI: 10.1016/J.Toxlet.2013.10.024 |
0.301 |
|
| 2012 |
Brandhuber F, Zengerle M, Porwol L, Tenberken O, Thiermann H, Worek F, Kubik S, Reiter G. Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups. Toxicology. 302: 163-71. PMID 22982866 DOI: 10.1016/J.Tox.2012.08.013 |
0.354 |
|
| 2011 |
Zengerle M, Brandhuber F, Schneider C, Worek F, Reiter G, Kubik S. Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent. Beilstein Journal of Organic Chemistry. 7: 1543-54. PMID 22238531 DOI: 10.3762/Bjoc.7.182 |
0.403 |
|
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