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Matthias Schiedel, PhD - Publications

Affiliations: 
Pharmacy University of Erlangen, Erlangen, Bayern, Germany 
Area:
Medicinal Chemistry
Website:
https://www.chemie.nat.fau.de/person/matthias-schiedel/
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Schiedel M, McArdle DJB, Padalino G, Chan AKN, Forde-Thomas J, McDonough M, Whiteland H, Beckmann M, Cookson R, Hoffmann KF, Conway SJ. Small Molecule Ligands of the BET-like Bromodomain, BRD3, Affect Survival, Oviposition, and Development. Journal of Medicinal Chemistry. PMID 38048437 DOI: 10.1021/acs.jmedchem.3c01321  0.564
2023 Sinatra L, Vogelmann A, Friedrich F, Tararina MA, Neuwirt E, Colcerasa A, König P, Toy L, Yesiloglu TZ, Hilscher S, Gaitzsch L, Papenkordt N, Zhai S, Zhang L, Romier C, ... ... Schiedel M, et al. Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. Journal of Medicinal Chemistry. 66: 14787-14814. PMID 37902787 DOI: 10.1021/acs.jmedchem.3c01385  0.588
2023 Thomas AM, Serafini M, Grant EK, Coombs EAJ, Bluck JP, Schiedel M, McDonough MA, Reynolds JK, Lee B, Platt M, Sharlandjieva V, Biggin PC, Duarte F, Milne TA, Bush JT, et al. Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. Acs Chemical Biology. PMID 37874862 DOI: 10.1021/acschembio.3c00437  0.563
2022 Huber ME, Toy L, Schmidt MF, Weikert D, Schiedel M. Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs. Chemistry (Weinheim An Der Bergstrasse, Germany). e202202565. PMID 36193681 DOI: 10.1002/chem.202202565  0.31
2022 Vogelmann A, Jung M, Hansen FK, Schiedel M. Comparison of Cellular Target Engagement Methods for the Tubulin Deacetylases Sirt2 and HDAC6: NanoBRET, CETSA, Tubulin Acetylation, and PROTACs. Acs Pharmacology & Translational Science. 5: 138-140. PMID 35187421 DOI: 10.1021/acsptsci.2c00004  0.553
2021 Brand M, Clayton J, Moroglu M, Schiedel M, Picaud S, Bluck JP, Skwarska A, Bolland H, Chan AKN, Laurin CMC, Scorah AR, See L, Rooney TPC, Andrews KH, Fedorov O, et al. Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain. Journal of Medicinal Chemistry. PMID 34255515 DOI: 10.1021/acs.jmedchem.1c00348  0.666
2020 Laurin CMC, Bluck JP, Chan AKN, Keller M, Boczek A, Scorah AR, See KFL, Jennings LE, Hewings DS, Woodhouse F, Reynolds JK, Schiedel M, Humphreys PG, Biggin PC, Conway SJ. Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of . Acs Infectious Diseases. PMID 33203208 DOI: 10.1021/acsinfecdis.0c00618  0.546
2020 Schiedel M, Lehotzky A, Szunyogh S, Oláh J, Hammelmann S, Wössner N, Robaa D, Einsle O, Sippl W, Ovádi J, Jung M. HaloTag-targeted Sirtuin rearranging ligand (SirReal) for the development of proteolysis targeting chimeras (PROTACs) against the lysine deacetylase Sirtuin 2 (Sirt2). Chembiochem : a European Journal of Chemical Biology. PMID 32672888 DOI: 10.1002/Cbic.202000351  0.582
2020 Schiedel M, Daub H, Itzen A, Jung M. Front Cover: Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology (ChemBioChem 8/2020) Chembiochem. 21: 1050-1050. DOI: 10.1002/Cbic.202000190  0.486
2019 Schiedel M, Daub H, Itzen A, Jung M. Validation of slow off-kinetics of Sirtuin Rearranging Ligands (SirReals) by means of the label-free electrically switchable nanolever technology. Chembiochem : a European Journal of Chemical Biology. PMID 31692222 DOI: 10.1002/Cbic.201900527  0.607
2019 Schiedel M, Moroglu M, Ascough DMH, Chamberlain AER, Kamps JJAG, Sekirnik AR, Conway SJ. Chemical epigenetics: the impact of chemical- and chemical biology techniques on bromodomain target validation. Angewandte Chemie (International Ed. in English). PMID 30633431 DOI: 10.1002/Anie.201812164  0.602
2019 Schiedel M, Moroglu M, Ascough DMH, Chamberlain AER, Kamps JJAG, Sekirnik AR, Conway SJ. Chemische Epigenetik: der Einfluss chemischer und chemo‐biologischer Techniken auf die Zielstruktur‐Validierung von Bromodomänen Angewandte Chemie. 131: 18096-18120. DOI: 10.1002/Ange.201812164  0.475
2018 Schiedel M, Conway SJ. Small molecules as tools to study the chemical epigenetics of lysine acetylation. Current Opinion in Chemical Biology. 45: 166-178. PMID 29958150 DOI: 10.1016/J.Cbpa.2018.06.015  0.613
2018 Robaa D, Monaldi D, Wössner N, Norio, Kudo, Rumpf T, Schiedel M, Yoshida M, Jung M. Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions. Chemical Record (New York, N.Y.). PMID 29931800 DOI: 10.1002/Tcr.201800044  0.625
2018 Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 29776834 DOI: 10.1016/J.Bmc.2018.05.003  0.599
2018 Swyter S, Schiedel M, Monaldi D, Szunyogh S, Lehotzky A, Rumpf T, Ovádi J, Sippl W, Jung M. New chemical tools for probing activity and inhibition of the NAD-dependent lysine deacylase sirtuin 2. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29685963 DOI: 10.1098/Rstb.2017.0083  0.643
2017 Schiedel M, Fallarero A, Luise C, Sippl W, Vuorela P, Jung M. Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Medchemcomm. 8: 465-470. PMID 30108764 DOI: 10.1039/C6Md00647G  0.569
2017 Szabó A, Oláh J, Szunyogh S, Lehotzky A, Szénási T, Csaplár M, Schiedel M, Lőw P, Jung M, Ovádi J. Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency. Scientific Reports. 7: 17070. PMID 29213065 DOI: 10.1038/S41598-017-17381-3  0.544
2017 Schiedel M, Herp D, Hammelmann S, Swyter S, Lehotzky A, Robaa D, Olah J, Ovádi J, Sippl W, Jung M. Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals). Journal of Medicinal Chemistry. PMID 28379698 DOI: 10.1021/Acs.Jmedchem.6B01872  0.607
2017 Schiedel M, Robaa D, Rumpf T, Sippl W, Jung M. The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets. Medicinal Research Reviews. PMID 28094444 DOI: 10.1002/Med.21436  0.595
2016 Galleano I, Schiedel M, Jung M, Madsen AS, Olsen CA. Correction to A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation. Journal of Medicinal Chemistry. 59: 2847. PMID 26936455 DOI: 10.1021/Acs.Jmedchem.6B00239  0.514
2016 Galleano I, Schiedel M, Jung M, Madsen AS, Olsen CA. A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation. Journal of Medicinal Chemistry. 59: 1021-31. PMID 26788965 DOI: 10.1021/Acs.Jmedchem.5B01532  0.604
2016 Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Structure-Based Development of an Affinity Probe for Sirtuin 2. Angewandte Chemie (International Ed. in English). PMID 26748890 DOI: 10.1002/Anie.201509843  0.625
2016 Galleano I, Schiedel M, Jung M, Madsen AS, Olsen CA. A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation Journal of Medicinal Chemistry. 59: 1021-1031. DOI: 10.1021/acs.jmedchem.5b01532  0.496
2016 Mathew NR, Baumgartner F, Waterhouse M, Müller TA, Schmitt-Gräff A, Weber A, Osswald L, Hanke K, Solsona ST, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, ... ... Schiedel M, et al. Sorafenib Promotes Graft-Versus-Leukemia Activity in Mice and Humans through IL-15 Production in Leukemia Cells Biology of Blood and Marrow Transplantation. 22. DOI: 10.1016/J.Bbmt.2015.11.389  0.453
2015 Schiedel M, Rumpf T, Karaman B, Lehotzky A, Oláh J, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Aminothiazoles as potent and selective Sirt2 inhibitors - a structure-activity relationship study. Journal of Medicinal Chemistry. PMID 26696402 DOI: 10.1021/Acs.Jmedchem.5B01517  0.63
2015 Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nature Communications. 6: 6263. PMID 25672491 DOI: 10.1038/Ncomms7263  0.622
2015 Schiedel M, Marek M, Lancelot J, Karaman B, Almlöf I, Schultz J, Sippl W, Pierce RJ, Romier C, Jung M. Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni. Journal of Biomolecular Screening. 20: 112-21. PMID 25325257 DOI: 10.1177/1087057114555307  0.612
2015 Schiedel M, Rumpf T, Karaman B, Lehotzky A, Gerhardt S, Ovádi J, Sippl W, Einsle O, Jung M. Strukturbasierte Entwicklung einer Affinitätssonde für Sirtuin 2 Angewandte Chemie. 128: 2293-2297. DOI: 10.1002/Ange.201509843  0.497
2014 Falenczyk C, Schiedel M, Karaman B, Rumpf T, Kuzmanovic N, Grøtli M, Sippl W, Jung M, König B. Chromo-pharmacophores: Photochromic diarylmaleimide inhibitors for sirtuins Chemical Science. 5: 4794-4799. DOI: 10.1039/C4Sc01346H  0.589
2011 Schiedel M, Jung M. [Dysregulation of histone acetylation as a molecular basis for the development of dementia]. Pharmazie in Unserer Zeit. 40: 297-9. PMID 21698626 DOI: 10.1002/Pauz.201190039  0.548
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