| Year |
Citation |
Score |
| 2023 |
Boby ML, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson MC, Chodera JD, Lee AA, London N, von Delft A, von Delft F, Achdout H, Aimon A, Alonzi DS, Arbon R, ... ... Zitzmann N, et al. Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science (New York, N.Y.). 382: eabo7201. PMID 37943932 DOI: 10.1126/science.abo7201 |
0.768 |
|
| 2023 |
Guay KP, Ibba R, Kiappes JL, Vasiljević S, Bonì F, De Benedictis M, Zeni I, Le Cornu JD, Hensen M, Chandran AV, Kantsadi AL, Caputo AT, Blanco Capurro JI, Bayo Y, Hill JC, ... ... Zitzmann N, et al. A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint. Iscience. 26: 107919. PMID 37822503 DOI: 10.1016/j.isci.2023.107919 |
0.755 |
|
| 2023 |
Tyrrell BE, Kumar A, Gangadharan B, Alonzi D, Brun J, Hill M, Bharucha T, Bosworth A, Graham V, Dowall S, Miller JL, Zitzmann N. Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays. Pathogens (Basel, Switzerland). 12. PMID 36986321 DOI: 10.3390/pathogens12030399 |
0.31 |
|
| 2022 |
Robinson PC, Liew DFL, Tanner HL, Grainger JR, Dwek RA, Reisler RB, Steinman L, Feldmann M, Ho LP, Hussell T, Moss P, Richards D, Zitzmann N. COVID-19 therapeutics: Challenges and directions for the future. Proceedings of the National Academy of Sciences of the United States of America. 119: e2119893119. PMID 35385354 DOI: 10.1073/pnas.2119893119 |
0.4 |
|
| 2022 |
Dwek RA, Bell JI, Feldmann M, Zitzmann N. Host-targeting oral antiviral drugs to prevent pandemics. Lancet (London, England). PMID 35344736 DOI: 10.1016/S0140-6736(22)00454-8 |
0.408 |
|
| 2022 |
Perera N, Brun J, Alonzi DS, Tyrrell BE, Miller JL, Zitzmann N. Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells. Antiviral Research. 199: 105269. PMID 35227758 DOI: 10.1016/j.antiviral.2022.105269 |
0.319 |
|
| 2021 |
Karade SS, Hill ML, Kiappes JL, Manne R, Aakula B, Zitzmann N, Warfield KL, Treston AM, Mariuzza RA. N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity. Journal of Medicinal Chemistry. 64: 18010-18024. PMID 34870992 DOI: 10.1021/acs.jmedchem.1c01377 |
0.799 |
|
| 2021 |
Sayce AC, Martinez FO, Tyrrell BE, Perera N, Hill ML, Dwek RA, Miller JL, Zitzmann N. Pathogen-induced inflammation is attenuated by the iminosugar MON-DNJ via modulation of the unfolded protein response. Immunology. PMID 34287854 DOI: 10.1111/imm.13393 |
0.468 |
|
| 2021 |
Brun J, Vasiljevic S, Gangadharan B, Hensen M, V Chandran A, Hill ML, Kiappes JL, Dwek RA, Alonzi DS, Struwe WB, Zitzmann N. Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike. Acs Central Science. 7: 586-593. PMID 34056088 DOI: 10.1021/acscentsci.1c00058 |
0.762 |
|
| 2021 |
Brun J, Vasiljevic S, Gangadharan B, Hensen M, V. Chandran A, Hill ML, Kiappes J, Dwek RA, Alonzi DS, Struwe WB, Zitzmann N. Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike Acs Central Science. 7: 586-593. DOI: 10.1021/acscentsci.1c00058 |
0.76 |
|
| 2020 |
Sobala ŁF, Fernandes PZ, Hakki Z, Thompson AJ, Howe JD, Hill M, Zitzmann N, Davies S, Stamataki Z, Butters TD, Alonzi DS, Williams SJ, Davies GJ. Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target. Proceedings of the National Academy of Sciences of the United States of America. PMID 33154157 DOI: 10.1073/pnas.2013620117 |
0.342 |
|
| 2020 |
Robinson CV, El-Baba TJ, Lutomski CA, Kantsadi AL, Malla TR, John T, Mikhailov V, Bolla JR, Schofield CJ, Zitzmann N, Vakonakis I. Allosteric inhibition of the SARS-CoV-2 main protease - insights from mass spectrometry-based assays. Angewandte Chemie (International Ed. in English). PMID 32841477 DOI: 10.1002/Anie.202010316 |
0.362 |
|
| 2020 |
Warfield K, Alonzi DS, Hill J, Caputo A, Roversi P, Kiappes JL, Sheets N, Duchars M, Dwek R, Biggins J, Barnard DL, Shresta S, Treston A, Zitzmann N. Targeting ER α-glucosidase I with a single-dose iminosugar treatment protects against lethal influenza and dengue virus infections. Journal of Medicinal Chemistry. PMID 32227946 DOI: 10.1021/Acs.Jmedchem.0C00067 |
0.784 |
|
| 2020 |
Bharucha T, Shearer FM, Vongsouvath M, Mayxay M, de Lamballerie X, Newton PN, Zitzmann N, Gould E, Dubot-Pérès A. A need to raise the bar - A systematic review of temporal trends in diagnostics for Japanese encephalitis virus infection, and perspectives for future research. International Journal of Infectious Diseases : Ijid : Official Publication of the International Society For Infectious Diseases. PMID 32205287 DOI: 10.1016/J.Ijid.2020.03.039 |
0.323 |
|
| 2019 |
Beier LS, Rossa J, Woodhouse S, Bergmann S, Kramer HB, Protze J, Eichner M, Piontek A, Vidal-Y-Sy S, Brandner JM, Krause G, Zitzmann N, Piontek J. Use of Modified Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells. International Journal of Molecular Sciences. 20. PMID 31561440 DOI: 10.3390/Ijms20194774 |
0.366 |
|
| 2019 |
Ansari MA, Aranday-Cortes E, Ip CL, da Silva Filipe A, Lau SH, Bamford C, Bonsall D, Trebes A, Piazza P, Sreenu V, Cowton VM, Ball J, Barnes E, Burgess G, ... ... Zitzmann N, et al. Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. Elife. 8. PMID 31478835 DOI: 10.7554/Elife.42463 |
0.372 |
|
| 2019 |
Miller JL, Hill ML, Brun J, Pountain A, Sayce AC, Zitzmann N. Iminosugars counteract the downregulation of the interferon γ receptor by dengue virus. Antiviral Research. 104551. PMID 31306674 DOI: 10.1016/J.Antiviral.2019.104551 |
0.339 |
|
| 2019 |
Oestringer BP, Bolivar JH, Claridge JK, Almanea L, Chipot C, Dehez F, Holzmann N, Schnell JR, Zitzmann N. Hepatitis C virus sequence divergence preserves p7 viroporin structural and dynamic features. Scientific Reports. 9: 8383. PMID 31182749 DOI: 10.1038/S41598-019-44413-X |
0.315 |
|
| 2019 |
Zhuang X, Magri A, Hill M, Lai AG, Kumar A, Rambhatla SB, Donald CL, Lopez-Clavijo AF, Rudge S, Pinnick K, Chang WH, Wing PAC, Brown R, Qin X, Simmonds P, ... ... Zitzmann N, et al. The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication. Nature Communications. 10: 377. PMID 30670689 DOI: 10.1038/S41467-019-08299-7 |
0.316 |
|
| 2019 |
Ansari MA, Aranday-Cortes E, Ip CL, Filipe AdS, Lau SH, Bamford C, Bonsall D, Trebes A, Piazza P, Sreenu V, Cowton VM, Ball J, Barnes E, Burgess G, Cooke G, ... ... Zitzmann N, et al. Author response: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus Elife. DOI: 10.7554/Elife.42463.027 |
0.306 |
|
| 2019 |
Wai Haan Y, M. Al-Bajalan H, Eukun Sage E, Elangovan D, Mat Yajit NL, Sarizan NM, Zitzmann N, Kiappes JL, Hasbullah SA, Ismail NH, Mackeen MM. α-GLUCOSIDASE INHIBITION OF LACTONE INTERMEDIATES OF THE IMINOSUGAR DEOXYNOJIRIMYCIN Jurnal Teknologi. 81. DOI: 10.11113/JT.V81.13079 |
0.771 |
|
| 2018 |
Kim YC, Lopez-Camacho C, Nettleship JE, Rahman N, Hill ML, Silva-Reyes L, Ortiz-Martinez G, Figueroa-Aguilar G, Mar MA, Vivanco-Cid H, Rollier CS, Zitzmann N, Viveros-Sandoval ME, Owens RJ, Reyes-Sandoval A. Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region. Virology Journal. 15: 193. PMID 30587198 DOI: 10.1186/S12985-018-1104-6 |
0.348 |
|
| 2018 |
Marti L, Lia A, Reca IB, Roversi P, Santino A, Zitzmann N. In Planta Preliminary Screening of ER Glycoprotein Folding Quality Control (ERQC) Modulators. International Journal of Molecular Sciences. 19. PMID 30041423 DOI: 10.3390/Ijms19072135 |
0.343 |
|
| 2018 |
Miller JL, Tyrrell BE, Zitzmann N. Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus. Advances in Experimental Medicine and Biology. 1062: 277-301. PMID 29845540 DOI: 10.1007/978-981-10-8727-1_20 |
0.476 |
|
| 2018 |
Caputo AT, Alonzi DS, Kiappes JL, Struwe WB, Cross A, Basu S, Darlot B, Roversi P, Zitzmann N. Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II. Advances in Experimental Medicine and Biology. 1062: 265-276. PMID 29845539 DOI: 10.1007/978-981-10-8727-1_19 |
0.785 |
|
| 2018 |
Behrens AJ, Kumar A, Medina-Ramirez M, Cupo A, Marshall K, Cruz Portillo VM, Harvey DJ, Ozorowski G, Zitzmann N, Wilson IA, Ward AB, Struwe WB, Moore JP, Sanders RW, Crispin M. Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages. Journal of Proteome Research. PMID 29420040 DOI: 10.1021/Acs.Jproteome.7B00639 |
0.332 |
|
| 2017 |
Kiappes JL, Hill ML, Alonzi DS, Miller JL, Iwaki R, Sayce AC, Caputo AT, Kato A, Zitzmann N. ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity. Acs Chemical Biology. PMID 29161006 DOI: 10.1021/Acschembio.7B00870 |
0.782 |
|
| 2017 |
Roversi P, Marti L, Caputo AT, Alonzi DS, Hill JC, Dent KC, Kumar A, Levasseur MD, Lia A, Waksman T, Basu S, Soto Albrecht Y, Qian K, McIvor JP, Lipp CB, ... ... Zitzmann N, et al. Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint. Proceedings of the National Academy of Sciences of the United States of America. PMID 28739903 DOI: 10.1073/Pnas.1703682114 |
0.337 |
|
| 2017 |
Alonzi DS, Scott KA, Dwek RA, Zitzmann N. Iminosugar antivirals: the therapeutic sweet spot. Biochemical Society Transactions. 45: 571-582. PMID 28408497 DOI: 10.1042/Bst20160182 |
0.567 |
|
| 2017 |
Perera N, Miller JL, Zitzmann N. The role of the unfolded protein response in dengue virus pathogenesis. Cellular Microbiology. PMID 28207988 DOI: 10.1111/Cmi.12734 |
0.371 |
|
| 2016 |
Tyrrell BE, Sayce AC, Warfield KL, Miller JL, Zitzmann N. Iminosugars: Promising therapeutics for influenza infection. Critical Reviews in Microbiology. 1-25. PMID 27931136 DOI: 10.1080/1040841X.2016.1242868 |
0.419 |
|
| 2016 |
Miller JL, Spiro SG, Dowall SD, Taylor I, Rule A, Alonzi DS, Sayce AC, Wright E, Bentley EM, Thom R, Hall G, Dwek RA, Hewson R, Zitzmann N. Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model. Plos One. 11: e0167018. PMID 27880800 DOI: 10.1371/Journal.Pone.0167018 |
0.492 |
|
| 2016 |
Behrens AJ, Harvey DJ, Milne E, Cupo A, Kumar A, Zitzmann N, Struwe WB, Moore JP, Crispin M. Molecular architecture of the cleavage-dependent mannose patch on a soluble HIV-1 envelope glycoprotein trimer. Journal of Virology. PMID 27807235 DOI: 10.1128/Jvi.01894-16 |
0.346 |
|
| 2016 |
Caputo AT, Alonzi DS, Marti L, Reca IB, Kiappes JL, Struwe WB, Cross A, Basu S, Lowe ED, Darlot B, Santino A, Roversi P, Zitzmann N. Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals. Proceedings of the National Academy of Sciences of the United States of America. PMID 27462106 DOI: 10.1073/Pnas.1604463113 |
0.791 |
|
| 2016 |
Crispin M, Zeltina A, Zitzmann N, Bowden TA. Native functionality and therapeutic targeting of arenaviral glycoproteins. Current Opinion in Virology. 18: 70-5. PMID 27104809 DOI: 10.1016/J.Coviro.2016.04.001 |
0.359 |
|
| 2016 |
Sayce AC, Alonzi DS, Killingbeck SS, Tyrrell BE, Hill ML, Caputo AT, Iwaki R, Kinami K, Ide D, Kiappes JL, Beatty PR, Kato A, Harris E, Dwek RA, Miller JL, ... Zitzmann N, et al. Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases-Not Glycolipid Processing Enzymes. Plos Neglected Tropical Diseases. 10: e0004524. PMID 26974655 DOI: 10.1371/Journal.Pntd.0004524 |
0.793 |
|
| 2016 |
Behrens AJ, Vasiljevic S, Pritchard LK, Harvey DJ, Andev RS, Krumm SA, Struwe WB, Cupo A, Kumar A, Zitzmann N, Seabright GE, Kramer HB, Spencer DI, Royle L, Lee JH, et al. Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein. Cell Reports. PMID 26972002 DOI: 10.1016/J.Celrep.2016.02.058 |
0.314 |
|
| 2016 |
Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJ, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E. Ion-channel function and cross-species determinants in viral assembly of nonprimate hepacivirus p7. Journal of Virology. PMID 26962224 DOI: 10.1128/Jvi.00132-16 |
0.335 |
|
| 2016 |
Warfield KL, Plummer EM, Sayce AC, Alonzi DS, Tang W, Tyrrell BE, Hill ML, Caputo AT, Killingbeck SS, Beatty PR, Harris E, Iwaki R, Kinami K, Ide D, Kiappes JL, ... ... Zitzmann N, et al. Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4. Antiviral Research. PMID 26946111 DOI: 10.1016/J.Antiviral.2016.03.001 |
0.78 |
|
| 2015 |
Kato A, Hirokami Y, Kinami K, Tsuji Y, Miyawaki S, Adachi I, Hollinshead J, Nash RJ, Kiappes JL, Zitzmann N, Cha JK, Molyneux RJ, Fleet GW, Asano N. Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors. Phytochemistry. 111: 124-31. PMID 25583438 DOI: 10.1016/J.Phytochem.2014.12.011 |
0.776 |
|
| 2015 |
Hussain S, Miller JL, Harvey DJ, Gu Y, Rosenthal PB, Zitzmann N, McCauley JW. Strain-specific antiviral activity of iminosugars against human influenza A viruses. The Journal of Antimicrobial Chemotherapy. 70: 136-52. PMID 25223974 DOI: 10.1093/Jac/Dku349 |
0.415 |
|
| 2014 |
Dalziel M, Crispin M, Scanlan CN, Zitzmann N, Dwek RA. Emerging principles for the therapeutic exploitation of glycosylation. Science (New York, N.Y.). 343: 1235681. PMID 24385630 DOI: 10.1126/Science.1235681 |
0.517 |
|
| 2014 |
Spiro S, McCaul N, Derking R, Alonzi D, Dwek R, Sanders R, Braakman I, Zitzmann N. Bypass of Quality Control in Protein Folding Pathways Induces Specific Misfolding of HIV Envelope V2 Loop: Implications for Iminosugars as Antivirals Aids Research and Human Retroviruses. 30: A49-A49. DOI: 10.1089/Aid.2014.5084.Abstract |
0.457 |
|
| 2013 |
Meredith Lw, Zitzmann N, McKeating J. Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission Antiviral Research. 100: 636-639. PMID 24157306 DOI: 10.1016/J.Antiviral.2013.10.006 |
0.371 |
|
| 2013 |
Sayce AC, Miller JL, Zitzmann N. Glucocorticosteroids as dengue therapeutics: resolving clinical observations with a primary human macrophage model. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 56: 901-3. PMID 23243185 DOI: 10.1093/Cid/Cis1048 |
0.311 |
|
| 2012 |
Miller JL, Lachica R, Sayce AC, Williams JP, Bapat M, Dwek R, Beatty PR, Harris E, Zitzmann N. Liposome-mediated delivery of iminosugars enhances efficacy against dengue virus in vivo. Antimicrobial Agents and Chemotherapy. 56: 6379-86. PMID 23070155 DOI: 10.1128/Aac.01554-12 |
0.53 |
|
| 2012 |
Gangadharan B, Bapat M, Rossa J, Antrobus R, Chittenden D, Kampa B, Barnes E, Klenerman P, Dwek RA, Zitzmann N. Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study. Plos One. 7: e39603. PMID 22761838 DOI: 10.1371/Journal.Pone.0039603 |
0.45 |
|
| 2011 |
Dorobantu C, Macovei A, Lazar C, Dwek RA, Zitzmann N, Branza-Nichita N. Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein. Journal of Virology. 85: 13373-83. PMID 21994451 DOI: 10.1128/Jvi.05423-11 |
0.531 |
|
| 2011 |
Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P, Dwek RA, Wallace BA, Biggin PC, Zitzmann N. The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein. Molecular Membrane Biology. 28: 254-64. PMID 21604991 DOI: 10.3109/09687688.2011.581253 |
0.46 |
|
| 2011 |
Gangadharan B, Antrobus R, Chittenden D, Rossa J, Bapat M, Klenerman P, Barnes E, Dwek RA, Zitzmann N. New approaches for biomarker discovery: the search for liver fibrosis markers in hepatitis C patients. Journal of Proteome Research. 10: 2643-50. PMID 21410221 DOI: 10.1021/Pr101077C |
0.451 |
|
| 2011 |
Gangadharan B, Bapat M, Rossa J, Antrobus R, Chittenden D, Kampa B, Barnes E, Dwek RA, Zitzmann N. OP15 Discovery of new liver fibrosis markers in hepatitis C patients using proteomics Gut. 60: A56-A56. DOI: 10.1136/Gutjnl-2011-300857B.15 |
0.455 |
|
| 2010 |
Pollock S, Nichita NB, Böhmer A, Radulescu C, Dwek RA, Zitzmann N. Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 17176-81. PMID 20855621 DOI: 10.1073/Pnas.1009445107 |
0.542 |
|
| 2010 |
Woodhouse SD, Narayan R, Latham S, Lee S, Antrobus R, Gangadharan B, Luo S, Schroth GP, Klenerman P, Zitzmann N. Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro Hepatology. 52: 443-453. PMID 20683944 DOI: 10.1002/Hep.23733 |
0.332 |
|
| 2010 |
Sayce AC, Miller JL, Zitzmann N. Targeting a host process as an antiviral approach against dengue virus. Trends in Microbiology. 18: 323-30. PMID 20452219 DOI: 10.1016/J.Tim.2010.04.003 |
0.39 |
|
| 2010 |
Pollock S, Antrobus R, Newton L, Kampa B, Rossa J, Latham S, Nichita NB, Dwek RA, Zitzmann N. Uptake and trafficking of liposomes to the endoplasmic reticulum. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1866-78. PMID 20097877 DOI: 10.1096/Fj.09-145755 |
0.52 |
|
| 2010 |
Macovei A, Radulescu C, Lazar C, Petrescu S, Durantel D, Dwek RA, Zitzmann N, Nichita NB. Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells. Journal of Virology. 84: 243-53. PMID 19846513 DOI: 10.1128/Jvi.01207-09 |
0.525 |
|
| 2010 |
Chew CF, Zitzmann N, Biggin PC. Deciphering the Relationship Between Hepatitis C Virus (HCV) P7 and Its Foes Biophysical Journal. 98: 654a. DOI: 10.1016/J.Bpj.2009.12.3587 |
0.306 |
|
| 2009 |
Antrobus R, Grant K, Gangadharan B, Chittenden D, Everett RD, Zitzmann N, Boutell C. Proteomic analysis of cells in the early stages of herpes simplex virus type-1 infection reveals widespread changes in the host cell proteome. Proteomics. 9: 3913-27. PMID 19670248 DOI: 10.1002/Pmic.200900207 |
0.355 |
|
| 2009 |
Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N. The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 106: 12712-6. PMID 19590017 DOI: 10.1073/Pnas.0905966106 |
0.501 |
|
| 2009 |
Chew CF, Vijayan R, Chang J, Zitzmann N, Biggin PC. Determination of pore-lining residues in the hepatitis C virus p7 protein. Biophysical Journal. 96: L10-2. PMID 19167280 DOI: 10.1016/J.Bpj.2008.10.004 |
0.324 |
|
| 2009 |
Narayan R, Gangadharan B, Hantz O, Antrobus R, García A, Dwek RA, Zitzmann N. Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection. Journal of Proteome Research. 8: 118-22. PMID 19053806 DOI: 10.1021/Pr800562J |
0.518 |
|
| 2009 |
Dunlop DC, Mansab F, Doores K, Zitzmann N, Smith D, Burton D, Dwek R, Scanlan C. P05-11. Yeast mannan genetics controls the molecular specificity of anti-carbohydrate antibodies cross-reactive to the HIV envelope Retrovirology. 6: P87. DOI: 10.1186/1742-4690-6-S3-P87 |
0.466 |
|
| 2008 |
Dunlop DC, Ulrich A, Appelmelk BJ, Burton DR, Dwek RA, Zitzmann N, Scanlan CN. Antigenic mimicry of the HIV envelope by AIDS-associated pathogens. Aids (London, England). 22: 2214-7. PMID 18832887 DOI: 10.1097/Qad.0B013E328314B5Df |
0.425 |
|
| 2008 |
Abd Hamid UM, Royle L, Saldova R, Radcliffe CM, Harvey DJ, Storr SJ, Pardo M, Antrobus R, Chapman CJ, Zitzmann N, Robertson JF, Dwek RA, Rudd PM. A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression. Glycobiology. 18: 1105-18. PMID 18818422 DOI: 10.1093/Glycob/Cwn095 |
0.451 |
|
| 2008 |
Pollock S, Dwek RA, Burton DR, Zitzmann N. N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery. Aids (London, England). 22: 1961-9. PMID 18753929 DOI: 10.1097/Qad.0B013E32830Efd96 |
0.487 |
|
| 2008 |
Woodhouse SD, Smith C, Michelet M, Branza-Nichita N, Hussey M, Dwek RA, Zitzmann N. Iminosugars in combination with interferon and ribavirin permanently eradicate noncytopathic bovine viral diarrhea virus from persistently infected cells. Antimicrobial Agents and Chemotherapy. 52: 1820-8. PMID 18316522 DOI: 10.1128/Aac.01181-07 |
0.543 |
|
| 2007 |
Gangadharan B, Antrobus R, Dwek RA, Zitzmann N. Novel serum biomarker candidates for liver fibrosis in hepatitis C patients. Clinical Chemistry. 53: 1792-9. PMID 17702858 DOI: 10.1373/Clinchem.2007.089144 |
0.471 |
|
| 2007 |
Scanlan CN, Ritchie GE, Baruah K, Crispin M, Harvey DJ, Singer BB, Lucka L, Wormald MR, Wentworth P, Zitzmann N, Rudd PM, Burton DR, Dwek RA. Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody. Journal of Molecular Biology. 372: 16-22. PMID 17631311 DOI: 10.1016/J.Jmb.2007.06.027 |
0.464 |
|
| 2007 |
Steinmann E, Whitfield T, Kallis S, Dwek RA, Zitzmann N, Pietschmann T, Bartenschlager R. Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology (Baltimore, Md.). 46: 330-8. PMID 17599777 DOI: 10.1002/Hep.21686 |
0.503 |
|
| 2007 |
Lazar C, Durantel D, Macovei A, Zitzmann N, Zoulim F, Dwek RA, Branza-Nichita N. Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity. Antiviral Research. 76: 30-7. PMID 17548120 DOI: 10.1016/J.Antiviral.2007.04.004 |
0.559 |
|
| 2007 |
Pardo M, García A, Antrobus R, Blanco MJ, Dwek RA, Zitzmann N. Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum. Journal of Proteome Research. 6: 2802-11. PMID 17539671 DOI: 10.1021/Pr070021T |
0.442 |
|
| 2007 |
Scanlan CN, Offer J, Zitzmann N, Dwek RA. Exploiting the defensive sugars of HIV-1 for drug and vaccine design. Nature. 446: 1038-45. PMID 17460665 DOI: 10.1038/Nature05818 |
0.465 |
|
| 2007 |
Pardo M, Dwek RA, Zitzmann N. Proteomics in uveal melanoma research: opportunities and challenges in biomarker discovery. Expert Review of Proteomics. 4: 273-86. PMID 17425462 DOI: 10.1586/14789450.4.2.273 |
0.436 |
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| 2007 |
Chapel C, Garcia C, Bartosch B, Roingeard P, Zitzmann N, Cosset FL, Dubuisson J, Dwek RA, Trépo C, Zoulim F, Durantel D. Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors. The Journal of General Virology. 88: 1133-43. PMID 17374756 DOI: 10.1099/Vir.0.82465-0 |
0.542 |
|
| 2007 |
Branza-Nichita NB, Lazar C, Macovei A, Durantel D, Dwek R, Zitzmann N. Targeting the host ER alpha glucosidases I and II as antiviral therapy Febs Journal. 274: 239-239. DOI: 10.1111/J.0014-2956.2007.05861_4.X |
0.476 |
|
| 2006 |
García A, Senis YA, Antrobus R, Hughes CE, Dwek RA, Watson SP, Zitzmann N. A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics. 6: 5332-43. PMID 16941570 DOI: 10.1002/Pmic.200600299 |
0.463 |
|
| 2006 |
Knight CG, Zitzmann N, Prabhakar S, Antrobus R, Dwek R, Hebestreit H, Rainey PB. Unraveling adaptive evolution: how a single point mutation affects the protein coregulation network. Nature Genetics. 38: 1015-22. PMID 16921374 DOI: 10.1038/Ng1867 |
0.439 |
|
| 2006 |
Macovei A, Zitzmann N, Lazar C, Dwek RA, Branza-Nichita N. Brefeldin A inhibits pestivirus release from infected cells, without affecting its assembly and infectivity. Biochemical and Biophysical Research Communications. 346: 1083-90. PMID 16782064 DOI: 10.1016/J.Bbrc.2006.06.023 |
0.54 |
|
| 2006 |
Popescu CI, Mares A, Zdrentu L, Zitzmann N, Dwek RA, Petrescu SM. Productive folding of tyrosinase ectodomain is controlled by the transmembrane anchor. The Journal of Biological Chemistry. 281: 21682-9. PMID 16737954 DOI: 10.1074/Jbc.M603841200 |
0.464 |
|
| 2006 |
Senis YA, Kim PY, Fuller GL, García A, Prabhakar S, Wilkinson MC, Brittan H, Zitzmann N, Wait R, Warrell DA, Watson SP, Kamiguti AS, Theakston RD, Nesheim ME, Laing GD. Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara. Biochimica Et Biophysica Acta. 1764: 863-71. PMID 16647309 DOI: 10.1016/J.Bbapap.2006.03.004 |
0.326 |
|
| 2006 |
Pardo M, García A, Thomas B, Piñeiro A, Akoulitchev A, Dwek RA, Zitzmann N. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker International Journal of Cancer. 119: 1014-1022. PMID 16570276 DOI: 10.1002/Ijc.21942 |
0.454 |
|
| 2006 |
Chapel C, Garcia C, Roingeard P, Zitzmann N, Dubuisson J, Dwek RA, Trépo C, Zoulim F, Durantel D. Antiviral effect of α-glucosidase inhibitors on viral morphogenesis and binding properties of hepatitis C virus-like particles Journal of General Virology. 87: 861-871. PMID 16528036 DOI: 10.1099/Vir.0.81503-0 |
0.545 |
|
| 2006 |
Patargias G, Zitzmann N, Dwek R, Fischer WB. Protein-protein interactions: modeling the hepatitis C virus ion channel p7. Journal of Medicinal Chemistry. 49: 648-55. PMID 16420050 DOI: 10.1021/Jm050721E |
0.483 |
|
| 2006 |
Chapel C, Zitzmann N, Zoulim F, Durantel D. Virus morphogenesis and viral entry as alternative targets for novel hepatitis C antivirals Future Virology. 1: 197-209. DOI: 10.2217/17460794.1.2.197 |
0.397 |
|
| 2006 |
Chapel C, Garcia C, Bartosch B, Roingeard P, Zitzmann N, Cosset F, Dubuisson J, Dwek R, Trepo C, Zoulim F, Durantel D. P.161 Alpha-glucosidase inhibitors prevent the assembly and induce a reduction of HCV infectivity Journal of Clinical Virology. 36. DOI: 10.1016/S1386-6532(06)80341-0 |
0.476 |
|
| 2006 |
Chapel C, Garcia C, Bartosch B, Roingeard P, Zitzmann N, Cosset FL, Dubuisson J, Dwek R, Trépo C, Zoulim F, Durantel D. CO 26-Les inhibiteurs des glucosidases induisent un mauvais repliement des glycoprotéines du VHC, perturbent l’assemblage viral et la sécrétion, et réduisent l’infectiosité des particules VHC résiduellement sécrétées Gastroenterologie Clinique Et Biologique. 30: 1046. DOI: 10.1016/S0399-8320(06)73405-4 |
0.409 |
|
| 2005 |
Durantel D, Branza-Nichita N, Durantel S, Dweek R, Zitzmann N. The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein. Advances in Experimental Medicine and Biology. 564: 5-6. PMID 16400799 DOI: 10.1007/0-387-25515-X_3 |
0.401 |
|
| 2005 |
Pavlovic D, Fischer W, Hussey M, Durantel D, Durantel S, Branza-Nichita N, Woodhouse S, Dwek RA, Zitzmann N. Long alkylchain iminosugars block the HCV P7 ion channel Advances in Experimental Medicine and Biology. 564: 3-4. PMID 16400798 DOI: 10.1007/0-387-25515-X_2 |
0.493 |
|
| 2005 |
Zitzmann N, Block T, Methta A, Rudd P, Burton D, Wilson I, Platt F, Butters T, Dwek RA. Glycosylation: Disease targets and therapy Advances in Experimental Medicine and Biology. 564: 1-2. PMID 16400797 DOI: 10.1007/0-387-25515-X_1 |
0.575 |
|
| 2005 |
Simmons A, Gangadharan B, Hodges A, Sharrocks K, Prabhakar S, García A, Dwek R, Zitzmann N, McMichael A. Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling. Immunity. 23: 621-34. PMID 16356860 DOI: 10.1016/J.Immuni.2005.11.003 |
0.46 |
|
| 2005 |
Pardo M, García A, Thomas B, Piñeiro A, Akoulitchev A, Dwek RA, Zitzmann N. Proteome analysis of a human uveal melanoma primary cell culture by 2-DE and MS Proteomics. 5: 4980-4993. PMID 16267820 DOI: 10.1002/Pmic.200500030 |
0.464 |
|
| 2005 |
García A, Watson SP, Dwek RA, Zitzmann N. Applying proteomics technology to platelet research Mass Spectrometry Reviews. 24: 918-930. PMID 15599945 DOI: 10.1002/Mas.20047 |
0.424 |
|
| 2004 |
Pardo M, Piñeiro A, De La Fuente M, García A, Prabhakar S, Zitzmann N, Dwek RA, Sánchez-Salorio M, Domínguez F, Capeans C. Abnormal cell cycle regulation in primary human uveal melanoma cultures Journal of Cellular Biochemistry. 93: 708-720. PMID 15660415 DOI: 10.1002/Jcb.20230 |
0.443 |
|
| 2004 |
Branza-Nichita N, Lazar C, Dwek RA, Zitzmann N. Role of N-glycan trimming in the folding and secretion of the pestivirus protein Erns Biochemical and Biophysical Research Communications. 319: 655-662. PMID 15178456 DOI: 10.1016/J.Bbrc.2004.05.039 |
0.516 |
|
| 2004 |
García-Alonso A, Prabhakar S, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N. Extensive analysis of the human platelet proteome by two-dimensional gel electrophoresis and mass spectrometry Proteomics. 4: 656-668. PMID 14997489 DOI: 10.1002/Pmic.200300665 |
0.456 |
|
| 2004 |
Durantel D, Carrouée-Durantel S, Branza-Nichita N, Dwek RA, Zitzmann N. Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus. Antimicrobial Agents and Chemotherapy. 48: 497-504. PMID 14742201 DOI: 10.1128/Aac.48.2.497-504.2004 |
0.542 |
|
| 2004 |
García A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood. 103: 2088-95. PMID 14645010 DOI: 10.1182/Blood-2003-07-2392 |
0.447 |
|
| 2003 |
Lazar C, Zitzmann N, Dwek RA, Branza-Nichita N. The pestivirus E(rns) glycoprotein interacts with E2 in both infected cells and mature virions. Virology. 314: 696-705. PMID 14554096 DOI: 10.1016/S0042-6822(03)00510-5 |
0.476 |
|
| 2003 |
Pavlović D, Neville DC, Argaud O, Blumberg B, Dwek RA, Fischer WB, Zitzmann N. The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proceedings of the National Academy of Sciences of the United States of America. 100: 6104-8. PMID 12719519 DOI: 10.1073/Pnas.1031527100 |
0.496 |
|
| 2002 |
Branza-Nichita N, Lazar C, Durantel D, Dwek RA, Zitzmann N. Role of disulfide bond formation in the folding and assembly of the envelope glycoproteins of a pestivirus. Biochemical and Biophysical Research Communications. 296: 470-6. PMID 12163043 DOI: 10.1016/S0006-291X(02)00907-5 |
0.521 |
|
| 2002 |
Dwek RA, Butters TD, Platt FM, Zitzmann N. Targeting glycosylation as a therapeutic approach. Nature Reviews. Drug Discovery. 1: 65-75. PMID 12119611 DOI: 10.1038/Nrd708 |
0.539 |
|
| 2002 |
Wu SF, Lee CJ, Liao CL, Dwek RA, Zitzmann N, Lin YL. Antiviral effects of an iminosugar derivative on flavivirus infections. Journal of Virology. 76: 3596-604. PMID 11907199 DOI: 10.1128/Jvi.76.8.3596-3604.2002 |
0.556 |
|
| 2001 |
Durantel D, Branza-Nichita N, Carrouée-Durantel S, Butters TD, Dwek RA, Zitzmann N. Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus. Journal of Virology. 75: 8987-98. PMID 11533162 DOI: 10.1128/Jvi.75.19.8987-8998.2001 |
0.563 |
|
| 2001 |
Branza-Nichita N, Durantel D, Carrouée-Durantel S, Dwek RA, Zitzmann N. Antiviral effect of N-butyldeoxynojirimycin against bovine viral diarrhea virus correlates with misfolding of E2 envelope proteins and impairment of their association into E1-E2 heterodimers. Journal of Virology. 75: 3527-36. PMID 11264342 DOI: 10.1128/Jvi.75.8.3527-3536.2001 |
0.478 |
|
| 2000 |
Chan-Fook C, Jiang W, Clarke BE, Zitzmann N, Maidens C, McKeating JA, Jones IM. Hepatitis C virus glycoprotein E2 binding to CD81: the role of E1E2 cleavage and protein glycosylation in bioactivity. Virology. 273: 60-66. PMID 10891408 DOI: 10.1006/Viro.2000.0407 |
0.314 |
|
| 2000 |
Rudd PM, Mattu TS, Zitzmann N, Mehta A, Colominas C, Hart E, Opdenakker G, Dwek RA. Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans. Biotechnology & Genetic Engineering Reviews. 16: 1-21. PMID 10819075 DOI: 10.1080/02648725.1999.10647969 |
0.507 |
|
| 1999 |
Zitzmann N, Mehta AS, Carrouée S, Butters TD, Platt FM, McCauley J, Blumberg BS, Dwek RA, Block TM. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proceedings of the National Academy of Sciences of the United States of America. 96: 11878-82. PMID 10518544 DOI: 10.1073/Pnas.96.21.11878 |
0.576 |
|
| 1998 |
Mehta A, Zitzmann N, Rudd PM, Block TM, Dwek RA. Alpha-glucosidase inhibitors as potential broad based anti-viral agents. Febs Letters. 430: 17-22. PMID 9678587 DOI: 10.1016/S0014-5793(98)00525-0 |
0.573 |
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