Laura M. Bohn, Ph.D. - Related publications

Affiliations: 
2003-2008 The Ohio State University College of Medicine 
 2009- Molecular Therapeutics & Neuroscience Scripps Research Institute Florida 
Area:
Pharmacology, Neuropharmacology, Neuroscience
Website:
http://www.scripps.edu/research/faculty/bohn
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2021 Degrandmaison J, Grisé O, Parent JL, Gendron L. Differential barcoding of opioid receptors trafficking. Journal of Neuroscience Research. PMID 34559903 DOI: 10.1002/jnr.24949   
2021 Dodu JC, Moncayo RK, Damaj MI, Schlosburg JE, Akbarali HI, O'Brien LD, Kendall DA, Lu D, Lichtman AH. The CB Receptor Positive Allosteric Modulator, ZCZ011, Attenuates Naloxone-Precipitated Diarrhea and Weight Loss in Oxycodone-Dependent Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 34625464 DOI: 10.1124/jpet.121.000723   
2021 Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. PMID 34433090 DOI: 10.1016/j.molcel.2021.07.033   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of Medicinal Chemistry. PMID 34505767 DOI: 10.1021/acs.jmedchem.1c01273   
2021 Zhang M, Xu B, Li N, Zhang R, Zhang Q, Shi X, Xu K, Xiao J, Chen D, Niu J, Shi Y, Fang Q. Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects. Journal of Medicinal Chemistry. PMID 34465090 DOI: 10.1021/acs.jmedchem.1c00694   
2021 Stahl EL, Bohn LM. Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists. Biochemistry. PMID 34468132 DOI: 10.1021/acs.biochem.1c00466   
2021 Turu G, Soltész-Katona E, Tóth AD, Juhász C, Cserző M, Misák Á, Balla A, Caron MG, Hunyady L. Biased Coupling to β-Arrestin of Two Common Variants of the CB Cannabinoid Receptor. Frontiers in Endocrinology. 12: 714561. PMID 34484125 DOI: 10.3389/fendo.2021.714561   
2021 Leo LM, Abood ME. CB1 Cannabinoid Receptor Signaling and Biased Signaling. Molecules (Basel, Switzerland). 26. PMID 34500853 DOI: 10.3390/molecules26175413   
2021 Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, et al. Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research. PMID 34561620 DOI: 10.1038/s41422-021-00569-8   
2021 Fan BW, Liu YL, Zhu GX, Wu B, Zhang MM, Deng Q, Wang JL, Chen JX, Han RW, Wei J. The active fragments of ghrelin cross the blood-brain barrier and enter the brain to produce antinociceptive effects after systemic administration. Canadian Journal of Physiology and Pharmacology. 1-12. PMID 34492212 DOI: 10.1139/cjpp-2020-0668   
2021 Aldrich JV, McLaughlin JP. Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development. Handbook of Experimental Pharmacology. PMID 34463847 DOI: 10.1007/164_2021_519   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Zamarripa CA, Pareek T, Schrock HM, Prisinzano TE, Blough BE, Sufka KJ, Freeman KB. The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats. Psychopharmacology. PMID 34430992 DOI: 10.1007/s00213-021-05965-x   
2021 Haider S, Pandey P, Reddy CR, Lambert JA, Chittiboyina AG. Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure-Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities. Acs Omega. 6: 20408-20421. PMID 34395989 DOI: 10.1021/acsomega.1c02413   
2021 Kong X, Li ZX, Gao YQ, Liu FH, Chen ZZ, Tian HG, Liu TX, Xu YY, Kang ZW. Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp, . Insects. 12. PMID 34442310 DOI: 10.3390/insects12080745   
2021 Boritzki V, Hübner H, Allikalt A, Gmeiner P, Wöhrl BM. Optimizing the Expression of Human Dopamine Receptors in . International Journal of Molecular Sciences. 22. PMID 34445358 DOI: 10.3390/ijms22168647   
2021 Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, et al. Positive allosteric mechanisms of adenosine A receptor-mediated analgesia. Nature. PMID 34497422 DOI: 10.1038/s41586-021-03897-2   
2021 Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent J. Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical Science. 12: 10990-11003. PMID 34522296 DOI: 10.1039/d1sc00749a   
2021 Li T, Wang L, Zhang L, Li B, Wang D, Zhang L, Wang T, Fu F. Rotigotine-loaded microspheres exerts the antinociceptive effect via central dopaminergic system. European Journal of Pharmacology. 174443. PMID 34464604 DOI: 10.1016/j.ejphar.2021.174443   
2021 van Aalst E, Wylie BJ. Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling. Frontiers in Molecular Biosciences. 8: 724603. PMID 34490352 DOI: 10.3389/fmolb.2021.724603   
2021 Gifford C, McGahan B, Miracle S, Minnema A, Murphy C, Vazquez D, Weaver T, Farhadi H. Perioperative Subcutaneous Methylnaltrexone Does Not Enhance Gastrointestinal Recovery after Posterior Short-Segment Spinal Arthrodesis Surgery: A Randomized Controlled Trial. The Spine Journal : Official Journal of the North American Spine Society. PMID 34419626 DOI: 10.1016/j.spinee.2021.08.004   
2021 Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239   
2021 Eguchi A, Ueki A, Hoshiyama J, Kuwata K, Chikaoka Y, Kawamura T, Nagatoishi S, Tsumoto K, Ueki R, Sando S. A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells. Jacs Au. 1: 578-585. PMID 34467321 DOI: 10.1021/jacsau.0c00121   
2021 Gonias SL. Plasminogen activator receptor assemblies in cell-signaling, innate immunity, and inflammation. American Journal of Physiology. Cell Physiology. PMID 34406905 DOI: 10.1152/ajpcell.00269.2021   
2021 Lee JC, Janda KD. Immunopharmacotherapeutic advancements in addressing methamphetamine abuse. Rsc Chemical Biology. 2: 77-93. PMID 34458776 DOI: 10.1039/d0cb00165a   
2021 Bailey AMJ, Li HO, Burns K, Cheng W, Collister D, Westby EP, Purdy KS, Walsh M, Tennankore KK. Targeting the Opioid Pathway for the Treatment of Chronic Kidney Disease Associated Pruritus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. The British Journal of Dermatology. PMID 34582571 DOI: 10.1111/bjd.20769   
2021 Subramanian S, Ravichandran M. Orexin receptors: Targets and applications. Fundamental & Clinical Pharmacology. PMID 34464995 DOI: 10.1111/fcp.12723   
2021 Lin JY, Yang Z, Yang C, Du JX, Yang F, Cheng J, Pan W, Zhang SJ, Yan X, Wang J, Wang J, Tie L, Yu X, Chen X, Sun JP. An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors. The Journal of Biological Chemistry. 101160. PMID 34480896 DOI: 10.1016/j.jbc.2021.101160   
2021 Sisignano M, Fischer MJM, Geisslinger G. Proton-Sensing GPCRs in Health and Disease. Cells. 10. PMID 34440817 DOI: 10.3390/cells10082050   
2021 Kilpatrick LE, Hill SJ. The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update. Biochemical Society Transactions. 49: 1547-1554. PMID 34436556 DOI: 10.1042/BST20201001   
2021 Deganutti G, Atanasio S, Rujan RM, Sexton PM, Wootten D, Reynolds CA. Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors. Frontiers in Molecular Biosciences. 8: 720561. PMID 34513925 DOI: 10.3389/fmolb.2021.720561   
2021 Yang MY, Kim SK, Kim D, Liggett SB, Goddard WA. Structures and Agonist Binding Sites of Bitter Taste Receptor TAS2R5 Complexed with Gi Protein and Validated against Experiment. The Journal of Physical Chemistry Letters. 9293-9300. PMID 34542294 DOI: 10.1021/acs.jpclett.1c02162   
2021 Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005   
2021 Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research. PMID 34433901 DOI: 10.1038/s41422-021-00552-3   
2021 Tao XX, Wang B, Zuo SK, Yu Y. [Identification of mouse lines with HA-tagged prostaglandin receptors]. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 73: 559-570. PMID 34405212   
2021 Cao AM, Quast RB, Fatemi F, Rondard P, Pin JP, Margeat E. Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state. Nature Communications. 12: 5426. PMID 34521824 DOI: 10.1038/s41467-021-25620-5   
2021 Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi-Agnihotri H, Banerjee R, Li XX, Cui CS, Lee JD, Kawakami K, Maharana J, Ranjan A, Chaturvedi M, Jhingan GD, et al. Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Molecular Cell. PMID 34582793 DOI: 10.1016/j.molcel.2021.09.007   
2021 Khan SA, Zia K, Ashraf S, Khan A, Ul-Haq Z. Theoretical investigation of selective ligand binding mode of galanin receptors. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34632940 DOI: 10.1080/07391102.2021.1977703   
2021 Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert D. Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Communications Biology. 4: 1062. PMID 34508168 DOI: 10.1038/s42003-021-02574-4   
2021 Zhao Y, Joshi AA, Aldrich JV, Murray TF. Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 143: 112173. PMID 34536757 DOI: 10.1016/j.biopha.2021.112173   
2021 Ren X, Gelinas AD, Linehan M, Iwasaki A, Wang W, Janjic N, Marie Pyle A. Title: Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA. Journal of Molecular Biology. 167227. PMID 34487794 DOI: 10.1016/j.jmb.2021.167227   
2021 Levick SP. Histamine receptors in heart failure. Heart Failure Reviews. PMID 34622365 DOI: 10.1007/s10741-021-10166-x   
2021 Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, et al. Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nature Chemical Biology. PMID 34556863 DOI: 10.1038/s41589-021-00866-8   
2021 Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z. Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Research. PMID 34526663 DOI: 10.1038/s41422-021-00566-x   
2021 Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis. Bioorganic & Medicinal Chemistry. 49: 116424. PMID 34626901 DOI: 10.1016/j.bmc.2021.116424   
2021 Dodat F, Mader S, Lévesque D. Minireview: what is known about SUMOylation among NR4A family members? Journal of Molecular Biology. 167212. PMID 34437889 DOI: 10.1016/j.jmb.2021.167212   
2021 Yang W, Nan H, Xu Z, Huang Z, Chen S, Li J, Li J, Yang H. DNA-Templated Glycan Labeling for Monitoring Receptor Spatial Distribution in Living Cells. Analytical Chemistry. PMID 34474560 DOI: 10.1021/acs.analchem.1c01815   
2021 Lenglez S, Sablon A, Fénelon G, Boland A, Deleuze JF, Boutoleau-Bretonnière C, Nicolas G, Demoulin JB. Distinct functional classes of PDGFRB pathogenic variants in primary familial brain calcification. Human Molecular Genetics. PMID 34494111 DOI: 10.1093/hmg/ddab258   
2021 Tasma Z, Siow A, Harris PWR, Brimble MA, Hay DL, Walker CS. Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: implications for drug discovery. British Journal of Pharmacology. PMID 34612509 DOI: 10.1111/bph.15700