George Yancopoulos, MD, PhD - Publications

Regeneron, Rensselaer, NY, United States 

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Patel G, Fury W, Yang H, Gomez-Caraballo M, Bai Y, Yang T, Adler C, Wei Y, Ni M, Schmitt H, Hu Y, Yancopoulos G, Stamer WD, Romano C. Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics. Proceedings of the National Academy of Sciences of the United States of America. PMID 32439707 DOI: 10.1073/Pnas.2001896117  0.371
2014 Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 111: 5147-52. PMID 24706858 DOI: 10.1073/Pnas.1323896111  0.41
2013 Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, ... ... Yancopoulos GD, et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Reports. 5: 654-65. PMID 24210820 DOI: 10.1016/J.Celrep.2013.10.007  0.353
2013 Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy A, Valenzuela D, Luo H, ... ... Yancopoulos G, et al. Correction to SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease. [Cell Reports 5, 7, (2013)] 654-665 Cell Reports. 5: 1479. DOI: 10.1016/J.Celrep.2013.11.036  0.344
2012 Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. Journal of Immunology (Baltimore, Md. : 1950). 188: 10-20. PMID 22187482  0.462
2010 Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 22207-12. PMID 21123744 DOI: 10.1073/Pnas.1015954107  0.403
2009 Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, et al. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. The Journal of Clinical Investigation. 119: 2359-65. PMID 19620773 DOI: 10.1172/Jci33877  0.321
2008 Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, Witte M. Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Developmental Biology. 319: 309-20. PMID 18514180 DOI: 10.1016/J.Ydbio.2008.04.024  0.302
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07  0.605
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057  0.361
2006 Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Yancopoulos GD, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/J.Cell.2005.11.044  0.376
2000 Hackett SF, Ozaki H, Strauss RW, Wahlin K, Suri C, Maisonpierre P, Yancopoulos G, Campochiaro PA. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. Journal of Cellular Physiology. 184: 275-84. PMID 10911358 DOI: 10.1002/1097-4652(200009)184:3<275::Aid-Jcp1>3.0.Co;2-7  0.303
1999 Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature. 400: 468-72. PMID 10440378 DOI: 10.1038/22788  0.416
1997 Symes A, Stahl N, Reeves SA, Farruggella T, Servidei T, Gearan T, Yancopoulos G, Fink JS. The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. Current Biology : Cb. 7: 697-700. PMID 9285712 DOI: 10.1016/S0960-9822(06)00298-3  0.343
1993 Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD, Jessell TM, Alt FW. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 227-31. PMID 7678338 DOI: 10.1073/Pnas.90.1.227  0.541
1992 Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes & Development. 6: 61-70. PMID 1730410 DOI: 10.1101/Gad.6.1.61  0.449
1992 Oltz EM, Yancopoulos GD, Morrow MA, Rolink A, Lee G, Wong F, Kaplan K, Gillis S, Melchers F, Alt FW. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. The Embo Journal. 11: 2759-67. PMID 1628631 DOI: 10.1002/J.1460-2075.1992.Tb05341.X  0.478
1992 Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW. Transcriptional down-regulation of N-myc expression during B-cell development. Molecular and Cellular Biology. 12: 1578-84. PMID 1549113 DOI: 10.1128/Mcb.12.4.1578  0.484
1991 Alt FW, Rathbun G, Yancopoulos GD. DNA recombination in the brain? Current Biology : Cb. 1: 3-5. PMID 15336189 DOI: 10.1016/0960-9822(91)90108-9  0.307
1991 Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J  0.394
1990 Yancopoulos GD, Nolan GP, Pollock R, Prockop S, Li SC, Herzenberg LA, Alt FW. A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Molecular and Cellular Biology. 10: 1697-704. PMID 2320007 DOI: 10.1128/mcb.10.4.1697-1704.1990  0.467
1990 Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. The Journal of Experimental Medicine. 171: 843-59. PMID 2261012 DOI: 10.1084/Jem.171.3.843  0.481
1990 Yancopoulos GD, Oltz EM, Rathbun G, Berman JE, Smith RK, Lansford RD, Rothman P, Okada A, Lee G, Morrow M. Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development. Proceedings of the National Academy of Sciences of the United States of America. 87: 5759-63. PMID 1696011 DOI: 10.1073/Pnas.87.15.5759  0.324
1989 Blackwell TK, Ferrier P, Malynn BA, Pollock RR, Covey LR, Suh HY, Heinke LB, Fulop GM, Phillips RA, Yancopoulos GD. The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement. Current Topics in Microbiology and Immunology. 152: 85-94. PMID 2805801 DOI: 10.1007/978-3-642-74974-2_12  0.323
1989 Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. The Embo Journal. 8: 735-42. PMID 2785917 DOI: 10.1002/J.1460-2075.1989.Tb03433.X  0.487
1989 Rathbun G, Alt FW, Yancopoulos GD. Immunology: making antigen-receptor genes. Nature. 342: 863-4. PMID 2594082 DOI: 10.1038/342863A0  0.41
1988 Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Current Topics in Microbiology and Immunology. 141: 100-9. PMID 3215042 DOI: 10.1007/978-3-642-74006-0_14  0.545
1988 Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 54: 453-60. PMID 3135938 DOI: 10.1016/0092-8674(88)90066-9  0.471
1988 Yancopoulos GD, Malynn BA, Alt FW. Developmentally regulated and strain-specific expression of murine VH gene families. The Journal of Experimental Medicine. 168: 417-35. PMID 3135366 DOI: 10.1084/Jem.168.1.417  0.454
1987 DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes & Development. 1: 1311-26. PMID 3322939 DOI: 10.1101/Gad.1.10.1311  0.582
1987 Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science (New York, N.Y.). 238: 1079-87. PMID 3317825 DOI: 10.1126/Science.3317825  0.395
1987 Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW. Expression of the immunoglobulin heavy-chain variable gene repertoire. Current Topics in Microbiology and Immunology. 135: 75-94. PMID 3107914 DOI: 10.1007/978-3-642-71851-9_6  0.471
1987 Alt FW, Yancopoulos GD. Circular T-cell receptor gene recombination products. Nature. 327: 189-90. PMID 3106830 DOI: 10.1038/327189A0  0.418
1987 DePinho R, Mitsock L, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P. Myc family of cellular oncogenes. Journal of Cellular Biochemistry. 33: 257-66. PMID 3034933 DOI: 10.1002/Jcb.240330404  0.544
1987 Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW. Structure and expression of the murine L-myc gene. The Embo Journal. 6: 3359-66. PMID 2828024  0.58
1986 Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F. Myc family genes: a dispersed multi-gene family. Annals of Clinical Research. 18: 284-9. PMID 3551773  0.552
1986 DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW. Structure and expression of the murine N-myc gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 1827-31. PMID 3513190 DOI: 10.1002/J.1460-2075.1987.Tb02657.X  0.625
1986 Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 324: 585-9. PMID 3491327 DOI: 10.1038/324585A0  0.496
1986 Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 44: 251-9. PMID 3484682 DOI: 10.1016/0092-8674(86)90759-2  0.506
1986 Yancopoulos GD, Alt FW. Regulation of the assembly and expression of variable-region genes. Annual Review of Immunology. 4: 339-68. PMID 3085692 DOI: 10.1146/Annurev.Iy.04.040186.002011  0.48
1986 Alt FW, Reth MG, Blackwell TK, Yancopoulos GD. Regulation of immunoglobulin variable-region gene assembly. The Mount Sinai Journal of Medicine, New York. 53: 166-9. PMID 3084957  0.454
1986 Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunological Reviews. 89: 5-30. PMID 3081433  0.607
1986 Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P. The human myc gene family. Cold Spring Harbor Symposia On Quantitative Biology. 51: 931-41. PMID 3034500 DOI: 10.1101/Sqb.1986.051.01.106  0.556
1986 Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. The Embo Journal. 5: 3259-66. PMID 3028778 DOI: 10.1002/J.1460-2075.1986.Tb04637.X  0.591
1986 Zimmerman KA, Yancopoulos GD, Collum RG, Smith RK, Kohl NE, Denis KA, Nau MM, Witte ON, Toran-Allerand D, Gee CE. Differential expression of myc family genes during murine development. Nature. 319: 780-3. PMID 2419762 DOI: 10.1038/319780A0  0.302
1985 Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP, Alt FW. N-myc can cooperate with ras to transform normal cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 82: 5455-9. PMID 3860871 DOI: 10.1073/Pnas.82.16.5455  0.42
1985 Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 40: 271-81. PMID 2578321 DOI: 10.1016/0092-8674(85)90141-2  0.502
1985 Alt FW, Keith Blackwell T, Yancopoulos GD. Immunoglobulin genes in transgenic mice Trends in Genetics. 1: 231-236. DOI: 10.1016/0168-9525(85)90089-7  0.456
1984 Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 311: 752-5. PMID 6092963 DOI: 10.1038/311752A0  0.589
1984 Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. 311: 727-33. PMID 6092962 DOI: 10.1038/311727A0  0.591
1984 Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. The Embo Journal. 3: 1209-19. PMID 6086308 DOI: 10.1002/J.1460-2075.1984.Tb01955.X  0.573
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