George Yancopoulos, MD, PhD - Publications

Affiliations: 
Regeneron, Rensselaer, NY, United States 

228 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Xin Y, Okamoto H, Kim J, Ni M, Adler C, Cavino K, Na E, Murphy AJ, Yancopoulos GD, Lin C, Gromada J. Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature. Endocrinology. en20161235. PMID 27466694 DOI: 10.1210/en.2016-1235  0.4
2016 Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, Pirozzi G, Sutherland ER, Evans RR, Joish VN, Eckert L, Graham NM, Stahl N, Yancopoulos GD, Louis-Tisserand M, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet (London, England). PMID 27130691 DOI: 10.1016/S0140-6736(16)30307-5  0.4
2016 Harp JB, Yancopoulos GD, Gromada J. Glucagon Orchestrates Stress-induced Hyperglycemia. Diabetes, Obesity & Metabolism. PMID 27027662 DOI: 10.1111/dom.12668  0.4
2016 Atanasio A, Decman V, White D, Ramos M, Ikiz B, Lee HC, Siao CJ, Brydges S, LaRosa E, Bai Y, Fury W, Burfeind P, Zamfirova R, Warshaw G, Orengo J, ... ... Yancopoulos G, et al. C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice. Scientific Reports. 6: 23204. PMID 26979938 DOI: 10.1038/srep23204  0.4
2016 Xin Y, Kim J, Ni M, Wei Y, Okamoto H, Lee J, Adler C, Cavino K, Murphy AJ, Yancopoulos GD, Lin HC, Gromada J. Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951663 DOI: 10.1073/pnas.1602306113  0.4
2016 Dewey FE, Gusarova V, O'Dushlaine C, Gottesman O, Trejos J, Hunt C, Van Hout CV, Habegger L, Buckler D, Lai KV, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Ledbetter DH, ... ... Yancopoulos GD, et al. Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. The New England Journal of Medicine. PMID 26933753 DOI: 10.1056/NEJMoa1510926  0.4
2016 Eichten A, Su J, Adler A, Zhang L, Ioffe E, Parveen AA, Yancopoulos GD, Rudge JS, Lowy I, Lin C, MacDonald D, Daly C, Duan X, Thurston G. Resistance to anti-VEGF therapy mediated by autocrine IL-6/STAT3 signaling and overcome by IL-6 blockade. Cancer Research. PMID 26921327 DOI: 10.1158/0008-5472.CAN-15-1443  0.4
2016 Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, Hellings P, Jiao L, Wang L, Evans RR, Pirozzi G, Graham NM, Swanson B, Hamilton JD, Radin A, ... ... Yancopoulos GD, et al. Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial. Jama. 315: 469-79. PMID 26836729 DOI: 10.1001/jama.2015.19330  0.4
2015 Smith EJ, Olson K, Haber LJ, Varghese B, Duramad P, Tustian AD, Oyejide A, Kirshner JR, Canova L, Menon J, Principio J, MacDonald D, Kantrowitz J, Papadopoulos N, Stahl N, ... Yancopoulos GD, et al. A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys. Scientific Reports. 5: 17943. PMID 26659273 DOI: 10.1038/srep17943  0.4
2015 Gandhi NA, Bennett BL, Graham NM, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nature Reviews. Drug Discovery. PMID 26471366 DOI: 10.1038/nrd4624  0.4
2015 Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky TB, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy AJ, Yancopoulos GD, Gromada J, Stitt T. Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice. Skeletal Muscle. 5: 34. PMID 26457176 DOI: 10.1186/s13395-015-0060-8  0.4
2015 Thaçi D, Simpson EL, Beck LA, Bieber T, Blauvelt A, Papp K, Soong W, Worm M, Szepietowski JC, Sofen H, Kawashima M, Wu R, Weinstein SP, Graham NM, Pirozzi G, ... ... Yancopoulos GD, et al. Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial. Lancet (London, England). PMID 26454361 DOI: 10.1016/S0140-6736(15)00388-8  0.4
2015 Mastaitis J, Eckersdorff M, Min S, Xin Y, Cavino K, Aglione J, Okamoto H, Na E, Stitt T, Dominguez MG, Schmahl JP, Lin C, Gale NW, Valenzuela DM, Murphy AJ, ... Yancopoulos GD, et al. Loss of SFRP4 Alters Body Size, Food Intake and Energy Expenditure in Diet-Induced Obese Male Mice. Endocrinology. en20151257. PMID 26406932 DOI: 10.1210/en.2015-1257  0.4
2015 Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabès JP, Carrié A, van Heyningen C, Carreau V, Farnier M, ... ... Yancopoulos GD, et al. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and its Specific Treatment with Alirocumab, a PCSK9 Monoclonal Antibody. Circulation. Cardiovascular Genetics. PMID 26374825 DOI: 10.1161/CIRCGENETICS.115.001129  0.4
2015 Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, ... ... Yancopoulos GD, et al. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Science Translational Medicine. 7: 303ra137. PMID 26333933 DOI: 10.1126/scitranslmed.aac4358  0.4
2015 Brown DM, Schmidt-Erfurth U, Do DV, Holz FG, Boyer DS, Midena E, Heier JS, Terasaki H, Kaiser PK, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, ... ... Yancopoulos GD, et al. Intravitreal Aflibercept for Diabetic Macular Edema: 100-Week Results From the VISTA and VIVID Studies. Ophthalmology. PMID 26198808 DOI: 10.1016/j.ophtha.2015.06.017  0.4
2015 Pascal KE, Coleman CM, Mujica AO, Kamat V, Badithe A, Fairhurst J, Hunt C, Strein J, Berrebi A, Sisk JM, Matthews KL, Babb R, Chen G, Lai KV, Huang TT, ... ... Yancopoulos GD, et al. Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124093 DOI: 10.1073/pnas.1510830112  0.4
2015 Okamoto H, Kim J, Aglione J, Lee J, Cavino K, Na E, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J. Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys. Endocrinology. 156: 2781-94. PMID 26020795 DOI: 10.1210/en.2015-1011  0.4
2015 Lai KM, Gong G, Atanasio A, Rojas J, Quispe J, Posca J, White D, Huang M, Fedorova D, Grant C, Miloscio L, Droguett G, Poueymirou WT, Auerbach W, Yancopoulos GD, et al. Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. Plos One. 10: e0125522. PMID 25909911 DOI: 10.1371/journal.pone.0125522  0.4
2015 Genovese MC, Fleischmann R, Kivitz AJ, Rell-Bakalarska M, Martincova R, Fiore S, Rohane P, van Hoogstraten H, Garg A, Fan C, van Adelsberg J, Weinstein SP, Graham NM, Stahl N, Yancopoulos GD, et al. Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1424-37. PMID 25733246 DOI: 10.1002/art.39093  0.4
2015 Mastaitis J, Min S, Elvert R, Kannt A, Xin Y, Ochoa F, Gale NW, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J. GPR17 gene disruption does not alter food intake or glucose homeostasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 112: 1845-9. PMID 25624481 DOI: 10.1073/pnas.1424968112  0.4
2015 Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 517: 381-5. PMID 25561180 DOI: 10.1038/nature14053  0.4
2015 Kuno J, Poueymirou WT, Gong G, Siao CJ, Clarke G, Esau L, Kojak N, Posca J, Atanasio A, Strein J, Yancopoulos GD, Lai KM, DeChiara TM, Frendewey D, Auerbach W, et al. Generation of fertile and fecund F0 XY female mice from XY ES cells. Transgenic Research. 24: 19-29. PMID 25087174 DOI: 10.1007/s11248-014-9815-y  0.4
2015 Sieper J, Braun J, Kay J, Badalamenti S, Radin AR, Jiao L, Fiore S, Momtahen T, Yancopoulos GD, Stahl N, Inman RD. Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN). Annals of the Rheumatic Diseases. 74: 1051-7. PMID 24550171 DOI: 10.1136/annrheumdis-2013-204963  0.4
2015 Miao H, Gale NW, Guo H, Qian J, Petty A, Kaspar J, Murphy AJ, Valenzuela DM, Yancopoulos G, Hambardzumyan D, Lathia JD, Rich JN, Lee J, Wang B. EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. Oncogene. 34: 558-67. PMID 24488013 DOI: 10.1038/onc.2013.590  0.4
2015 Gusarova V, Alexa CA, Wang Y, Rafique A, Kim JH, Buckler D, Mintah IJ, Shihanian LM, Cohen JC, Hobbs HH, Xin Y, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys Journal of Lipid Research. 56: 1308-1317. DOI: 10.1194/jlr.M054890  0.4
2014 Hamilton JD, Suárez-Fariñas M, Dhingra N, Cardinale I, Li X, Kostic A, Ming JE, Radin AR, Krueger JG, Graham N, Yancopoulos GD, Pirozzi G, Guttman-Yassky E. Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis. The Journal of Allergy and Clinical Immunology. 134: 1293-300. PMID 25482871 DOI: 10.1016/j.jaci.2014.10.013  0.4
2014 Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 159: 691-6. PMID 25417115 DOI: 10.1016/j.cell.2014.09.027  0.4
2014 Korobelnik JF, Do DV, Schmidt-Erfurth U, Boyer DS, Holz FG, Heier JS, Midena E, Kaiser PK, Terasaki H, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, ... ... Yancopoulos GD, et al. Intravitreal aflibercept for diabetic macular edema. Ophthalmology. 121: 2247-54. PMID 25012934 DOI: 10.1016/j.ophtha.2014.05.006  0.4
2014 Beck LA, Thaçi D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R, Simpson E, Ardeleanu M, Weinstein SP, Pirozzi G, Guttman-Yassky E, Suárez-Fariñas M, ... ... Yancopoulos GD, et al. Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. The New England Journal of Medicine. 371: 130-9. PMID 25006719 DOI: 10.1056/NEJMoa1314768  0.4
2014 Macdonald LE, Karow M, Stevens S, Auerbach W, Poueymirou WT, Yasenchak J, Frendewey D, Valenzuela DM, Giallourakis CC, Alt FW, Yancopoulos GD, Murphy AJ. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proceedings of the National Academy of Sciences of the United States of America. 111: 5147-52. PMID 24706858 DOI: 10.1073/pnas.1323896111  0.4
2014 Murphy AJ, Macdonald LE, Stevens S, Karow M, Dore AT, Pobursky K, Huang TT, Poueymirou WT, Esau L, Meola M, Mikulka W, Krueger P, Fairhurst J, Valenzuela DM, Papadopoulos N, ... Yancopoulos GD, et al. Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 5153-8. PMID 24706856 DOI: 10.1073/pnas.1324022111  0.4
2014 Huizinga TW, Fleischmann RM, Jasson M, Radin AR, van Adelsberg J, Fiore S, Huang X, Yancopoulos GD, Stahl N, Genovese MC. Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial. Annals of the Rheumatic Diseases. 73: 1626-34. PMID 24297381 DOI: 10.1136/annrheumdis-2013-204405  0.4
2014 Schmidt-Erfurth U, Kaiser PK, Korobelnik JF, Brown DM, Chong V, Nguyen QD, Ho AC, Ogura Y, Simader C, Jaffe GJ, Slakter JS, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, et al. Intravitreal aflibercept injection for neovascular age-related macular degeneration: ninety-six-week results of the VIEW studies. Ophthalmology. 121: 193-201. PMID 24084500 DOI: 10.1016/j.ophtha.2013.08.011  0.4
2013 Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, ... ... Yancopoulos GD, et al. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Elife. 2: e01749. PMID 24381249 DOI: 10.7554/eLife.01749  0.4
2013 Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, ... ... Yancopoulos GD, et al. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Reports. 5: 654-65. PMID 24210820 DOI: 10.1016/j.celrep.2013.10.007  0.4
2013 Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, ... ... Yancopoulos GD, et al. Conditionals by inversion provide a universal method for the generation of conditional alleles. Proceedings of the National Academy of Sciences of the United States of America. 110: E3179-88. PMID 23918385 DOI: 10.1073/pnas.1217812110  0.4
2013 Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, Wang L, Kirkesseli S, Rocklin R, Bock B, Hamilton J, Ming JE, Radin A, Stahl N, Yancopoulos GD, et al. Dupilumab in persistent asthma with elevated eosinophil levels. The New England Journal of Medicine. 368: 2455-66. PMID 23688323 DOI: 10.1056/NEJMoa1304048  0.4
2013 Bouleti C, Mathivet T, Coqueran B, Serfaty JM, Lesage M, Berland E, Ardidie-Robouant C, Kauffenstein G, Henrion D, Lapergue B, Mazighi M, Duyckaerts C, Thurston G, Valenzuela DM, Murphy AJ, ... Yancopoulos GD, et al. Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke. European Heart Journal. 34: 3657-68. PMID 23674618 DOI: 10.1093/eurheartj/eht153  0.4
2013 Mitha E, Schumacher HR, Fouche L, Luo SF, Weinstein SP, Yancopoulos GD, Wang J, King-Davis S, Evans RR. Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial. Rheumatology (Oxford, England). 52: 1285-92. PMID 23485476 DOI: 10.1093/rheumatology/ket114  0.4
2013 Eichten A, Adler AP, Cooper B, Griffith J, Wei Y, Yancopoulos GD, Lin HC, Thurston G. Rapid decrease in tumor perfusion following VEGF blockade predicts long-term tumor growth inhibition in preclinical tumor models. Angiogenesis. 16: 429-41. PMID 23238831 DOI: 10.1007/s10456-012-9328-3  0.4
2013 McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. IL-22 promotes fibroblast-mediated wound repair in the skin. The Journal of Investigative Dermatology. 133: 1321-9. PMID 23223145 DOI: 10.1038/jid.2012.463  0.4
2013 Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD, Thurston G. Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Research. 73: 108-18. PMID 23149917 DOI: 10.1158/0008-5472.CAN-12-2064  0.4
2012 Heier JS, Brown DM, Chong V, Korobelnik JF, Kaiser PK, Nguyen QD, Kirchhof B, Ho A, Ogura Y, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Soo Y, Anderesi M, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 119: 2537-48. PMID 23084240 DOI: 10.1016/j.ophtha.2012.09.006  0.4
2012 Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 491: 259-63. PMID 23075849 DOI: 10.1038/nature11535  0.4
2012 Schumacher HR, Evans RR, Saag KG, Clower J, Jennings W, Weinstein SP, Yancopoulos GD, Wang J, Terkeltaub R. Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study. Arthritis Care & Research. 64: 1462-70. PMID 22549879 DOI: 10.1002/acr.21690  0.4
2012 Billiard F, Lobry C, Darrasse-Jèze G, Waite J, Liu X, Mouquet H, DaNave A, Tait M, Idoyaga J, Leboeuf M, Kyratsous CA, Burton J, Kalter J, Klinakis A, Zhang W, ... ... Yancopoulos GD, et al. Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. The Journal of Experimental Medicine. 209: 1011-28. PMID 22547652 DOI: 10.1084/jem.20111615  0.4
2012 Stein EA, Mellis S, Yancopoulos GD, Stahl N, Logan D, Smith WB, Lisbon E, Gutierrez M, Webb C, Wu R, Du Y, Kranz T, Gasparino E, Swergold GD. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. The New England Journal of Medicine. 366: 1108-18. PMID 22435370 DOI: 10.1056/NEJMoa1105803  0.4
2012 Papadopoulos N, Martin J, Ruan Q, Rafique A, Rosconi MP, Shi E, Pyles EA, Yancopoulos GD, Stahl N, Wiegand SJ. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 15: 171-85. PMID 22302382 DOI: 10.1007/s10456-011-9249-6  0.4
2012 Schumacher HR, Sundy JS, Terkeltaub R, Knapp HR, Mellis SJ, Stahl N, Yancopoulos GD, Soo Y, King-Davis S, Weinstein SP, Radin AR. Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis and Rheumatism. 64: 876-84. PMID 22223180 DOI: 10.1002/art.33412  0.4
2012 Kincaid EZ, Che JW, York I, Escobar H, Reyes-Vargas E, Delgado JC, Welsh RM, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rock KL. Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nature Immunology. 13: 129-35. PMID 22197977 DOI: 10.1038/ni.2203  0.4
2012 Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. Journal of Immunology (Baltimore, Md. : 1950). 188: 10-20. PMID 22187482  0.4
2012 Galaup A, Gomez E, Souktani R, Durand M, Cazes A, Monnot C, Teillon J, Le Jan S, Bouleti C, Briois G, Philippe J, Pons S, Martin V, Assaly R, Bonnin P, ... ... Yancopoulos GD, et al. Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4. Circulation. 125: 140-9. PMID 22086875 DOI: 10.1161/CIRCULATIONAHA.111.049072  0.4
2012 Gusarova V, Howard VG, Okamoto H, Koehler-Stec EM, Papadopoulos N, Murphy AJ, Yancopoulos GD, Stahl N, Sleeman MW. Reduction of LDL cholesterol by a monoclonal antibody to PCSK9 in rodents and nonhuman primates Clinical Lipidology. 7: 737-743. DOI: 10.2217/clp.12.70  0.4
2011 Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG. Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Science Signaling. 4: ra79. PMID 22114146 DOI: 10.1126/scisignal.2002223  0.4
2011 Perdiguero EG, Galaup A, Durand M, Teillon J, Philippe J, Valenzuela DM, Murphy AJ, Yancopoulos GD, Thurston G, Germain S. Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice. The Journal of Biological Chemistry. 286: 36841-51. PMID 21832056 DOI: 10.1074/jbc.M111.220061  0.4
2011 Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood. 118: 3119-28. PMID 21791433 DOI: 10.1182/blood-2010-12-326926  0.4
2011 Heier JS, Boyer D, Nguyen QD, Marcus D, Roth DB, Yancopoulos G, Stahl N, Ingerman A, Vitti R, Berliner AJ, Yang K, Brown DM. The 1-year results of CLEAR-IT 2, a phase 2 study of vascular endothelial growth factor trap-eye dosed as-needed after 12-week fixed dosing. Ophthalmology. 118: 1098-106. PMID 21640258 DOI: 10.1016/j.ophtha.2011.03.020  0.4
2011 Brown DM, Heier JS, Ciulla T, Benz M, Abraham P, Yancopoulos G, Stahl N, Ingerman A, Vitti R, Berliner AJ, Yang K, Nguyen QD. Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. Ophthalmology. 118: 1089-97. PMID 21640257 DOI: 10.1016/j.ophtha.2011.02.039  0.4
2011 Billiard F, Kirshner JR, Tait M, Danave A, Taheri S, Zhang W, Waite JC, Olson K, Chen G, Coetzee S, Hylton D, Murphy AJ, Yancopoulos GD, Thurston G, Skokos D. Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. European Journal of Immunology. 41: 2207-16. PMID 21598246 DOI: 10.1002/eji.201041343  0.4
2011 Lobov IB, Cheung E, Wudali R, Cao J, Halasz G, Wei Y, Economides A, Lin HC, Papadopoulos N, Yancopoulos GD, Wiegand SJ. The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow. Blood. 117: 6728-37. PMID 21498671 DOI: 10.1182/blood-2010-08-302067  0.4
2011 Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, ... ... Yancopoulos GD, et al. Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 108: 2807-12. PMID 21282641 DOI: 10.1073/pnas.1019761108  0.4
2011 Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 2378-83. PMID 21262827 DOI: 10.1073/pnas.1019524108  0.4
2011 Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proceedings of the National Academy of Sciences of the United States of America. 108: 2390-5. PMID 21262803 DOI: 10.1073/pnas.1019682108  0.4
2011 Azuma YT, Matsuo Y, Nakajima H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Takeuchi T. Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection. Journal of Pharmacological Sciences. 115: 105-11. PMID 21157117 DOI: JST.JSTAGE/jphs/10R02CR  0.4
2010 Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 22207-12. PMID 21123744 DOI: 10.1073/pnas.1015954107  0.4
2010 Yancopoulos GD. Clinical application of therapies targeting VEGF. Cell. 143: 13-6. PMID 20887885 DOI: 10.1016/j.cell.2010.09.028  0.4
2010 Demaria O, Pagni PP, Traub S, de Gassart A, Branzk N, Murphy AJ, Valenzuela DM, Yancopoulos GD, Flavell RA, Alexopoulou L. TLR8 deficiency leads to autoimmunity in mice. The Journal of Clinical Investigation. 120: 3651-62. PMID 20811154 DOI: 10.1172/JCI42081  0.4
2010 Frendewey D, Chernomorsky R, Esau L, Om J, Xue Y, Murphy AJ, Yancopoulos GD, Valenzuela DM. The loss-of-allele assay for ES cell screening and mouse genotyping. Methods in Enzymology. 476: 295-307. PMID 20691873 DOI: 10.1016/S0076-6879(10)76017-1  0.4
2010 DeChiara TM, Poueymirou WT, Auerbach W, Frendewey D, Yancopoulos GD, Valenzuela DM. Producing fully ES cell-derived mice from eight-cell stage embryo injections. Methods in Enzymology. 476: 285-94. PMID 20691872 DOI: 10.1016/S0076-6879(10)76016-X  0.4
2010 Cao J, Zhao L, Li Y, Liu Y, Xiao W, Song Y, Luo L, Huang D, Yancopoulos GD, Wiegand SJ, Wen R. A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap. Investigative Ophthalmology & Visual Science. 51: 6009-17. PMID 20538989 DOI: 10.1167/iovs.09-4956  0.4
2010 Hoffman HM, Scott P, Mueller JL, Misaghi A, Stevens S, Yancopoulos GD, Murphy A, Valenzuela DM, Liu-Bryan R. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis and Rheumatism. 62: 2170-9. PMID 20506351 DOI: 10.1002/art.27456  0.4
2010 Shmelkov SV, Hormigo A, Jing D, Proenca CC, Bath KG, Milde T, Shmelkov E, Kushner JS, Baljevic M, Dincheva I, Murphy AJ, Valenzuela DM, Gale NW, Yancopoulos GD, Ninan I, et al. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nature Medicine. 16: 598-602, 1p followin. PMID 20418887 DOI: 10.1038/nm.2125  0.4
2010 Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 7467-72. PMID 20231469 DOI: 10.1073/pnas.1002271107  0.4
2010 Zhu H, Mingler MK, McBride ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Williams MT, Vorhees CV, Rothenberg ME. Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology. 35: 1119-32. PMID 20171785 DOI: 10.1016/j.psyneuen.2010.01.012  0.4
2010 Azuma YT, Matsuo Y, Kuwamura M, Yancopoulos GD, Valenzuela DM, Murphy AJ, Nakajima H, Karow M, Takeuchi T. Interleukin-19 protects mice from innate-mediated colonic inflammation. Inflammatory Bowel Diseases. 16: 1017-28. PMID 19834971 DOI: 10.1002/ibd.21151  0.4
2010 Valenzuela DM, Yancopoulos GD. VelociGene and VelociMouse: High-Throughput Approaches for Generating Targeted Mutations in Mice on a Genome-Wide Scale Encyclopedia of Neuroscience. 67-73. DOI: 10.1016/B978-008045046-9.00889-5  0.4
2009 Li Z, Huang H, Boland P, Dominguez MG, Burfeind P, Lai KM, Lin HC, Gale NW, Daly C, Auerbach W, Valenzuela D, Yancopoulos GD, Thurston G. Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22399-404. PMID 20018779 DOI: 10.1073/pnas.0911189106  0.4
2009 Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, et al. Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. The Journal of Clinical Investigation. 119: 2359-65. PMID 19620773 DOI: 10.1172/JCI33877  0.4
2009 Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Vahdat L, et al. Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis. Circulation Research. 105: 201-8. PMID 19542015 DOI: 10.1161/CIRCRESAHA.109.196790  0.4
2009 Torres R, Macdonald L, Croll SD, Reinhardt J, Dore A, Stevens S, Hylton DM, Rudge JS, Liu-Bryan R, Terkeltaub RA, Yancopoulos GD, Murphy AJ. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Annals of the Rheumatic Diseases. 68: 1602-8. PMID 19528034 DOI: 10.1136/ard.2009.109355  0.4
2009 Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M, Swain GP, Yancopoulos GD, Valenzuela DM, Murphy A, Karow M, Stevens S, Pearce EJ, Artis D. Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung. The Journal of Experimental Medicine. 206: 937-52. PMID 19349464 DOI: 10.1084/jem.20082048  0.4
2009 Dechiara TM, Poueymirou WT, Auerbach W, Frendewey D, Yancopoulos GD, Valenzuela DM. VelociMouse: fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos. Methods in Molecular Biology (Clifton, N.J.). 530: 311-24. PMID 19266341 DOI: 10.1007/978-1-59745-471-1_16  0.4
2009 Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M. Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Molecular Endocrinology (Baltimore, Md.). 23: 324-36. PMID 19131512 DOI: 10.1210/me.2008-0045  0.4
2009 Huang J, Bae JO, Tsai JP, Kadenhe-Chiweshe A, Papa J, Lee A, Zeng S, Kornfeld ZN, Ullner P, Zaghloul N, Ioffe E, Nandor S, Burova E, Holash J, Thurston G, ... ... Yancopoulos GD, et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. International Journal of Oncology. 34: 79-87. PMID 19082480 DOI: 10.3892/ijo_00000131  0.4
2009 Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 136: 257-67. PMID 18992745 DOI: 10.1053/j.gastro.2008.10.018  0.4
2009 Nair MG, Du Y, Perrigoue JG, Zaph C, Taylor JJ, Goldschmidt M, Swain GP, Yancopoulos GD, Valenzuela DM, Murphy A, Karow M, Stevens S, Pearce EJ, Artis D. Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung (Journal of Experimental Medicine (2009) 206, 4, (937-952)) Journal of Experimental Medicine. 206: 1201. DOI: 10.1084/jem.2008204841009c  0.4
2008 Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 29: 947-57. PMID 19100701 DOI: 10.1016/j.immuni.2008.11.003  0.4
2008 Nair MG, Guild KJ, Du Y, Zaph C, Yancopoulos GD, Valenzuela DM, Murphy A, Stevens S, Karow M, Artis D. Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. Journal of Immunology (Baltimore, Md. : 1950). 181: 4709-15. PMID 18802073  0.4
2008 Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF. The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis. The Journal of Experimental Medicine. 205: 2099-110. PMID 18710929 DOI: 10.1084/jem.20072484  0.4
2008 Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N, Mellis SJ. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis and Rheumatism. 58: 2443-52. PMID 18668535 DOI: 10.1002/art.23687  0.4
2008 Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, Witte M. Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Developmental Biology. 319: 309-20. PMID 18514180 DOI: 10.1016/j.ydbio.2008.04.024  0.4
2008 Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, ... Yancopoulos GD, et al. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. The Journal of Clinical Investigation. 118: 2111-20. PMID 18497886 DOI: 10.1172/JCI34401  0.4
2008 Long DA, Price KL, Ioffe E, Gannon CM, Gnudi L, White KE, Yancopoulos GD, Rudge JS, Woolf AS. Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury. Kidney International. 74: 300-9. PMID 18480750 DOI: 10.1038/ki.2008.179  0.4
2008 Lu C, Thaker PH, Lin YG, Spannuth W, Landen CN, Merritt WM, Jennings NB, Langley RR, Gershenson DM, Yancopoulos GD, Ellis LM, Jaffe RB, Coleman RL, Sood AK. Impact of vessel maturation on antiangiogenic therapy in ovarian cancer. American Journal of Obstetrics and Gynecology. 198: 477.e1-9; discussion. PMID 18395047 DOI: 10.1016/j.ajog.2007.12.028  0.4
2008 Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, et al. The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development (Cambridge, England). 135: 1713-23. PMID 18353862 DOI: 10.1242/dev.015149  0.4
2008 Kadenhe-Chiweshe A, Papa J, McCrudden KW, Frischer J, Bae JO, Huang J, Fisher J, Lefkowitch JH, Feirt N, Rudge J, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Molecular Cancer Research : McR. 6: 1-9. PMID 18234958 DOI: 10.1158/1541-7786.MCR-07-0101  0.4
2008 Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL. Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections. Journal of Immunology (Baltimore, Md. : 1950). 180: 1704-12. PMID 18209067  0.4
2008 Ramalingam TR, Pesce JT, Sheikh F, Cheever AW, Mentink-Kane MM, Wilson MS, Stevens S, Valenzuela DM, Murphy AJ, Yancopoulos GD, Urban JF, Donnelly RP, Wynn TA. Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nature Immunology. 9: 25-33. PMID 18066066 DOI: 10.1038/ni1544  0.4
2008 Tanaka M, Endo S, Okuda T, Economides AN, Valenzuela DM, Murphy AJ, Robertson E, Sakurai T, Fukatsu A, Yancopoulos GD, Kita T, Yanagita M. Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Kidney International. 73: 181-91. PMID 17943079 DOI: 10.1038/sj.ki.5002626  0.4
2008 Rudge JS, Ioffe E, Cao J, Papadopoulos N, Thurston G, Wiegand SJ, Yancopoulos GD. Clinical development of VEGF trap Angiogenesis: An Integrative Approach From Science to Medicine. 415-420. DOI: 10.1007/978-0-387-71518-6_36  0.4
2008 Thurston G, Noguera-Troise I, Lobov IB, Daly C, Rudge JS, Gale NW, Wiegand SJ, Yancopoulos GD. Delta-like ligand 4/Notch pathway in tumor angiogenesis Angiogenesis: An Integrative Approach From Science to Medicine. 217-224. DOI: 10.1007/978-0-387-71518-6_19  0.4
2007 Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Novartis Foundation Symposium. 283: 106-20; discussion 1. PMID 18300417  0.4
2007 Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, Papadopoulos N, Pyles EA, Torri A, Wiegand SJ, Thurston G, Stahl N, Yancopoulos GD. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proceedings of the National Academy of Sciences of the United States of America. 104: 18363-70. PMID 18000042 DOI: 10.1073/pnas.0708865104  0.4
2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/MCB.01636-07  0.4
2007 Wortley KE, Garcia K, Okamoto H, Thabet K, Anderson KD, Shen V, Herman JP, Valenzuela D, Yancopoulos GD, Tschöp MH, Murphy A, Sleeman MW. Peptide YY regulates bone turnover in rodents. Gastroenterology. 133: 1534-43. PMID 17920065 DOI: 10.1053/j.gastro.2007.08.024  0.4
2007 Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 27: 647-59. PMID 17919941 DOI: 10.1016/j.immuni.2007.07.023  0.4
2007 Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, et al. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 449: 346-50. PMID 17882221 DOI: 10.1038/nature06129  0.4
2007 Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB. Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development (Cambridge, England). 134: 3723-32. PMID 17804598 DOI: 10.1242/dev.008599  0.4
2007 Verheul HM, Hammers H, van Erp K, Wei Y, Sanni T, Salumbides B, Qian DZ, Yancopoulos GD, Pili R. Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 4201-8. PMID 17634549 DOI: 10.1158/1078-0432.CCR-06-2553  0.4
2007 Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science (New York, N.Y.). 316: 604-8. PMID 17463289 DOI: 10.1126/science.1141229  0.4
2007 Thurston G, Noguera-Troise I, Yancopoulos GD. The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nature Reviews. Cancer. 7: 327-31. PMID 17457300 DOI: 10.1038/nrc2130  0.4
2007 Kasselman LJ, Kintner J, Sideris A, Pasnikowski E, Krellman JW, Shah S, Rudge JS, Yancopoulos GD, Wiegand SJ, Croll SD. Dexamethasone treatment and ICAM-1 deficiency impair VEGF-induced angiogenesis in adult brain. Journal of Vascular Research. 44: 283-91. PMID 17406120 DOI: 10.1159/000101450  0.4
2007 Torres R, Croll SD, Vercollone J, Reinhardt J, Griffiths J, Zabski S, Anderson KD, Adams NC, Gowen L, Sleeman MW, Valenzuela DM, Wiegand SJ, Yancopoulos GD, Murphy AJ. Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Pain. 130: 267-78. PMID 17379411 DOI: 10.1016/j.pain.2007.01.036  0.4
2007 Dominguez MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, Noguera-Troise I, Murphy AJ, Valenzuela DM, Davis S, Thurston G, Yancopoulos GD, Gale NW. Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 3243-8. PMID 17360632 DOI: 10.1073/pnas.0611510104  0.4
2007 Okamoto H, Latres E, Liu R, Thabet K, Murphy A, Valenzeula D, Yancopoulos GD, Stitt TN, Glass DJ, Sleeman MW. Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes. 56: 1350-6. PMID 17303803 DOI: 10.2337/db06-1448  0.4
2007 Lobov IB, Renard RA, Papadopoulos N, Gale NW, Thurston G, Yancopoulos GD, Wiegand SJ. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proceedings of the National Academy of Sciences of the United States of America. 104: 3219-24. PMID 17296940 DOI: 10.1073/pnas.0611206104  0.4
2007 Shimoda H, Bernas MJ, Witte MH, Gale NW, Yancopoulos GD, Kato S. Abnormal recruitment of periendothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice. Cell and Tissue Research. 328: 329-37. PMID 17235601 DOI: 10.1007/s00441-006-0360-8  0.4
2007 Wachsberger PR, Burd R, Cardi C, Thakur M, Daskalakis C, Holash J, Yancopoulos GD, Dicker AP. VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. International Journal of Radiation Oncology, Biology, Physics. 67: 1526-37. PMID 17234361 DOI: 10.1016/j.ijrobp.2006.11.011  0.4
2007 Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escaravage JM, Esau L, Doré AT, Stevens S, Adams NC, Dominguez MG, Gale NW, Yancopoulos GD, DeChiara TM, Valenzuela DM. F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nature Biotechnology. 25: 91-9. PMID 17187059 DOI: 10.1038/nbt1263  0.4
2007 Gale NW, Prevo R, Espinosa J, Ferguson DJ, Dominguez MG, Yancopoulos GD, Thurston G, Jackson DG. Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Molecular and Cellular Biology. 27: 595-604. PMID 17101772 DOI: 10.1128/MCB.01503-06  0.4
2007 Davies J, Eichmann A, Kitajewski J, Wilkins A, Lammert E, Yancopoulos GD, Adams RH, Betsholtz C, Shibuya M, Gerhardt H, Drake CJ, Ruhrberg C, Wilting J, Uv AE, Owens GK. Discussion Novartis Foundation Symposium. 283: 80-86.  0.4
2006 Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature. 444: 1032-7. PMID 17183313 DOI: 10.1038/nature05355  0.4
2006 Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 15491-6. PMID 17030814 DOI: 10.1073/pnas.0607538103  0.4
2006 Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/j.cell.2006.06.057  0.4
2006 Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, Neurath MF. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. Journal of Immunology (Baltimore, Md. : 1950). 177: 2760-4. PMID 16920909  0.4
2006 Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. The Journal of Allergy and Clinical Immunology. 118: 257-68. PMID 16815164 DOI: 10.1016/j.jaci.2006.04.039  0.4
2006 Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, ... ... Yancopoulos GD, et al. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine. 12: 793-800. PMID 16799557 DOI: 10.1038/nm1428  0.4
2006 Holash J, Thurston G, Rudge JS, Yancopoulos GD, Adjei AA, Bergers G, Pytowski B, Pegram M, Gordon MS. Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents. Cancer Metastasis Reviews. 25: 243-52. PMID 16770536 DOI: 10.1007/s10555-006-8504-6  0.4
2006 Perry BN, Govindarajan B, Bhandarkar SS, Knaus UG, Valo M, Sturk C, Carrillo CO, Sohn A, Cerimele F, Dumont D, Losken A, Williams J, Brown LF, Tan X, Ioffe E, ... Yancopoulos GD, et al. Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice. The Journal of Investigative Dermatology. 126: 2316-22. PMID 16741507 DOI: 10.1038/sj.jid.5700413  0.4
2006 Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, ... ... Yancopoulos GD, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/j.cell.2005.11.044  0.4
2006 Amici SA, Dunn WA, Murphy AJ, Adams NC, Gale NW, Valenzuela DM, Yancopoulos GD, Notterpek L. Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1179-89. PMID 16436605 DOI: 10.1523/JNEUROSCI.2618-05.2006  0.4
2005 Rudge JS, Thurston G, Davis S, Papadopoulos N, Gale N, Wiegand SJ, Yancopoulos GD. VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets. Cold Spring Harbor Symposia On Quantitative Biology. 70: 411-8. PMID 16869778 DOI: 10.1101/sqb.2005.70.052  0.4
2005 Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, Yancopoulos GD, Wiegand SJ, Sleeman MW. Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metabolism. 2: 421-7. PMID 16330327 DOI: 10.1016/j.cmet.2005.11.004  0.4
2005 Towne CF, York IA, Neijssen J, Karow ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Neefjes JJ, Rock KL. Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation. Journal of Immunology (Baltimore, Md. : 1950). 175: 6605-14. PMID 16272315  0.4
2005 Hu L, Hofmann J, Holash J, Yancopoulos GD, Sood AK, Jaffe RB. Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model Clinical Cancer Research. 11: 6966-6971. PMID 16203789 DOI: 10.1158/1078-0432.CCR-05-0910  0.4
2005 Thurston G, Wang Q, Baffert F, Rudge J, Papadopoulos N, Jean-Guillaume D, Wiegand S, Yancopoulos GD, McDonald DM. Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period Development. 132: 3317-3326. PMID 15958513 DOI: 10.1242/dev.01888  0.4
2005 Choi GB, Dong HW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Swanson LW, Anderson DJ. Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Neuron. 46: 647-60. PMID 15944132 DOI: 10.1016/j.neuron.2005.04.011  0.4
2005 Oshima Y, Oshima S, Nambu H, Kachi S, Takahashi K, Umeda N, Shen J, Dong A, Apte RS, Duh E, Hackett SF, Okoye G, Ishibashi K, Handa J, Melia M, ... ... Yancopoulos G, et al. Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 963-5. PMID 15802489 DOI: 10.1096/fj.04-2209fje  0.4
2005 Kasus-Jacobi A, Ou J, Birch DG, Locke KG, Shelton JM, Richardson JA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Edwards AO. Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. The Journal of Biological Chemistry. 280: 20413-20. PMID 15790565 DOI: 10.1074/jbc.M413789200  0.4
2005 Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ. Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proceedings of the National Academy of Sciences of the United States of America. 102: 2496-501. PMID 15699348 DOI: 10.1073/pnas.0409849102  0.4
2005 Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nature Medicine. 11: 199-205. PMID 15654325 DOI: 10.1038/nm1178  0.4
2005 Thurston G, Rudge JS, Ioffe E, Papadopoulos N, Daly C, Vuthoori S, Daly T, Wiegand SJ, Yancopoulos GD. The anti-inflammatory actions of angiopoietin-1. Exs. 233-45. PMID 15617482  0.4
2005 Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD, Glass DJ. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. The Journal of Biological Chemistry. 280: 2737-44. PMID 15550386 DOI: 10.1074/jbc.M407517200  0.4
2004 Pitera JE, Woolf AS, Gale NW, Yancopoulos GD, Yuan HT. Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. The American Journal of Pathology. 165: 1895-906. PMID 15579434 DOI: 10.1016/S0002-9440(10)63242-7  0.4
2004 Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proceedings of the National Academy of Sciences of the United States of America. 101: 15949-54. PMID 15520367 DOI: 10.1073/pnas.0407290101  0.4
2004 Lai KM, Gonzalez M, Poueymirou WT, Kline WO, Na E, Zlotchenko E, Stitt TN, Economides AN, Yancopoulos GD, Glass DJ. Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy. Molecular and Cellular Biology. 24: 9295-304. PMID 15485899 DOI: 10.1128/MCB.24.21.9295-9304.2004  0.4
2004 Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, ... ... Yancopoulos GD, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/ng0904-921  0.4
2004 Zhou YF, Stabile E, Walker J, Shou M, Baffour R, Yu Z, Rott D, Yancopoulos GD, Rudge JS, Epstein SE. Effects of gene delivery on collateral development in chronic hypoperfusion: diverse effects of angiopoietin-1 versus vascular endothelial growth factor. Journal of the American College of Cardiology. 44: 897-903. PMID 15312878 DOI: 10.1016/j.jacc.2004.05.046  0.4
2004 Frischer JS, Huang J, Serur A, Kadenhe-Chiweshe A, McCrudden KW, O'Toole K, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature International Journal of Oncology. 25: 549-553. PMID 15289855  0.4
2004 Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts American Journal of Pathology. 165: 35-52. PMID 15215160  0.4
2004 Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proceedings of the National Academy of Sciences of the United States of America. 101: 8227-32. PMID 15148384 DOI: 10.1073/pnas.0402763101  0.4
2004 Croll SD, Ransohoff RM, Cai N, Zhang Q, Martin FJ, Wei T, Kasselman LJ, Kintner J, Murphy AJ, Yancopoulos GD, Wiegand SJ. VEGF-mediated inflammation precedes angiogenesis in adult brain. Experimental Neurology. 187: 388-402. PMID 15144865 DOI: 10.1016/j.expneurol.2004.02.010  0.4
2004 Daly C, Wong V, Burova E, Wei Y, Zabski S, Griffiths J, Lai KM, Lin HC, Ioffe E, Yancopoulos GD, Rudge JS. Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes & Development. 18: 1060-71. PMID 15132996 DOI: 10.1101/gad.1189704  0.4
2004 Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Molecular Cell. 14: 395-403. PMID 15125842 DOI: 10.1016/S1097-2765(04)00211-4  0.4
2004 Nambu H, Nambu R, Oshima Y, Hackett SF, Okoye G, Wiegand S, Yancopoulos G, Zack DJ, Campochiaro PA. Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier. Gene Therapy. 11: 865-73. PMID 15042118 DOI: 10.1038/sj.gt.3302230  0.4
2004 Huang J, Frischer JS, New T, Kim ES, Serur A, Lee A, Kadenhe-Chiwishe A, Pollyea DA, Yokoi A, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. TNP-470 promotes initial vascular sprouting in xenograft tumors Molecular Cancer Therapeutics. 3: 335-343. PMID 15026554  0.4
2004 Feldheim DA, Nakamoto M, Osterfield M, Gale NW, DeChiara TM, Rohatgi R, Yancopoulos GD, Flanagan JG. Loss-of-function analysis of EphA receptors in retinotectal mapping. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2542-50. PMID 15014130 DOI: 10.1523/JNEUROSCI.0239-03.2004  0.4
2004 Saucier C, Khoury H, Lai KM, Peschard P, Dankort D, Naujokas MA, Holash J, Yancopoulos GD, Muller WJ, Pawson T, Park M. The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 2345-50. PMID 14983012 DOI: 10.1073/pnas.0308065101  0.4
2003 Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, Yancopoulos GD, Jaffe RB. Vascular Endothelial Growth Factor-Trap Decreases Tumor Burden, Inhibits Ascites, and Causes Dramatic Vascular Remodeling in an Ovarian Cancer Model Clinical Cancer Research. 9: 5721-5728. PMID 14654557  0.4
2003 Sleeman MW, Garcia K, Liu R, Murray JD, Malinova L, Moncrieffe M, Yancopoulos GD, Wiegand SJ. Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 14297-302. PMID 14610276 DOI: 10.1073/pnas.2335926100  0.4
2003 Harfouche R, Gratton JP, Yancopoulos GD, Noseda M, Karsan A, Hussain SNA. Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1523-1525. PMID 12824293  0.4
2003 Huang J, Frischer JS, Serur A, Kadenhe A, Yokoi A, McCrudden KW, New T, O'Toole K, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Yamashiro DJ, Kandel JJ. Regression of established tumors and metastases by potent vascular endothelial growth factor blockade. Proceedings of the National Academy of Sciences of the United States of America. 100: 7785-90. PMID 12805568 DOI: 10.1073/pnas.1432908100  0.4
2003 Anderson KD, Lambert PD, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ. Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice. Journal of Neuroendocrinology. 15: 649-60. PMID 12787049 DOI: 10.1046/j.1365-2826.2003.01043.x  0.4
2003 Larcher F, Franco M, Bolontrade M, Rodriguez-Puebla M, Casanova L, Navarro M, Yancopoulos G, Jorcano JL, Conti CJ. Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis Molecular Carcinogenesis. 37: 83-90. PMID 12766907 DOI: 10.1002/mc.10126  0.4
2003 Rudge JS, Thurston G, Yancopoulos GD. Angiopoietin-1 and pulmonary hypertension: cause or cure? Circulation Research. 92: 947-9. PMID 12750304 DOI: 10.1161/01.RES.0000074031.94558.99  0.4
2003 Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, ... ... Yancopoulos GD, et al. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nature Biotechnology. 21: 652-9. PMID 12730667 DOI: 10.1038/nbt822  0.4
2003 Xia YP, Li B, Hylton D, Detmar M, Yancopoulos GD, Rudge JS. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood. 102: 161-8. PMID 12649136 DOI: 10.1182/blood-2002-12-3793  0.4
2003 Ongusaha PP, Kim Ji, Fang L, Wong TW, Yancopoulos GD, Aaronson SA, Lee SW. p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop Embo Journal. 22: 1289-1301. PMID 12628922 DOI: 10.1093/emboj/cdg129  0.4
2003 Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. VEGF-dependent conjunctivalization of the corneal surface. Investigative Ophthalmology & Visual Science. 44: 117-23. PMID 12506063 DOI: 10.1167/iovs.01-1277  0.4
2003 Economides AN, Carpenter LR, Rudge JS, Wong V, Koehler-Stec EM, Hartnett C, Pyles EA, Xu X, Daly TJ, Young MR, Fandl JP, Lee F, Carver S, McNay J, Bailey K, ... ... Yancopoulos GD, et al. Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nature Medicine. 9: 47-52. PMID 12483208 DOI: 10.1038/nm811  0.4
2003 Davis S, Papadopoulos N, Aldrich TH, Maisonpierre PC, Huang T, Kovac L, Xu A, Leidich R, Radziejewska E, Rafique A, Goldberg J, Jain V, Bailey K, Karow M, Fandl J, ... ... Yancopoulos GD, et al. Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nature Structural Biology. 10: 38-44. PMID 12469114 DOI: 10.1038/nsb880  0.4
2002 Gale NW, Thurston G, Davis S, Wiegand SJ, Holash J, Rudge JS, Yancopoulos GD. Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation. Cold Spring Harbor Symposia On Quantitative Biology. 67: 267-73. PMID 12858549  0.4
2002 Cheng N, Brantley DM, Liu H, Lin Q, Enriquez M, Gale N, Yancopoulos G, Cerretti DP, Daniel TO, Chen J. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Molecular Cancer Research : McR. 1: 2-11. PMID 12496364  0.4
2002 Uemura A, Ogawa M, Hirashima M, Fujiwara T, Koyama S, Takagi H, Honda Y, Wiegand SJ, Yancopoulos GD, Nishikawa S. Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. The Journal of Clinical Investigation. 110: 1619-28. PMID 12464667 DOI: 10.1172/JCI15621  0.4
2002 Gale NW, Thurston G, Hackett SF, Renard R, Wang Q, McClain J, Martin C, Witte C, Witte MH, Jackson D, Suri C, Campochiaro PA, Wiegand SJ, Yancopoulos GD. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Developmental Cell. 3: 411-23. PMID 12361603 DOI: 10.1016/S1534-5807(02)00217-4  0.4
2002 Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, Soffer SZ, Ring L, New T, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America. 99: 11399-404. PMID 12177446 DOI: 10.1073/pnas.172398399  0.4
2002 Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, ... ... Yancopoulos GD, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proceedings of the National Academy of Sciences of the United States of America. 99: 11393-8. PMID 12177445 DOI: 10.1073/pnas.172398299  0.4
2002 Yue Y, Chen ZY, Gale NW, Blair-Flynn J, Hu TJ, Yue X, Cooper M, Crockett DP, Yancopoulos GD, Tessarollo L, Zhou R. Mistargeting hippocampal axons by expression of a truncated Eph receptor. Proceedings of the National Academy of Sciences of the United States of America. 99: 10777-82. PMID 12124402 DOI: 10.1073/pnas.162354599  0.4
2002 Hackett SF, Wiegand S, Yancopoulos G, Campochiaro PA. Angiopoietin-2 plays an important role in retinal angiogenesis Journal of Cellular Physiology. 192: 182-187. PMID 12115724 DOI: 10.1002/jcp.10128  0.4
2002 Harfouche R, Hasséssian HM, Guo Y, Faivre V, Srikant CB, Yancopoulos GD, Hussain SNA. Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells Microvascular Research. 64: 135-147. PMID 12074640 DOI: 10.1006/mvre.2002.2421  0.4
2002 Kim I, Ryu YS, Kwak HJ, Ahn SY, Oh JL, Yancopoulos GD, Gale NW, Koh GY. EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1126-1128. PMID 12039842  0.4
2002 Joussen AM, Poulaki V, Tsujikawa A, Qin W, Qaum T, Xu Q, Moromizato Y, Bursell SE, Wiegand SJ, Rudge J, Ioffe E, Yancopoulos GD, Adamis AP. Suppression of diabetic retinopathy with angiopoietin-1. The American Journal of Pathology. 160: 1683-93. PMID 12000720 DOI: 10.1016/S0002-9440(10)61115-7  0.4
2002 Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. The Journal of Clinical Investigation. 109: 805-15. PMID 11901189 DOI: 10.1172/JCI13776  0.4
2002 Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC. Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. The Journal of Biological Chemistry. 277: 19206-12. PMID 11884411 DOI: 10.1074/jbc.M201078200  0.4
2002 Dunn SE, Simard AR, Prud'homme RA, Michel RN. Calcineurin and skeletal muscle growth. Nature Cell Biology. 4: E46; author reply E4. PMID 11875443 DOI: 10.1038/ncb0302-e46a  0.4
2002 Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. The American Journal of Pathology. 160: 501-9. PMID 11839570 DOI: 10.1016/S0002-9440(10)64869-9  0.4
2001 Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nature Cell Biology. 3: 1014-9. PMID 11715023 DOI: 10.1038/ncb1101-1014  0.4
2001 Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nature Cell Biology. 3: 1009-13. PMID 11715022 DOI: 10.1038/ncb1101-1009  0.4
2001 Thurston G, Yancopoulos GD. Developmental biology: Gridlock in the blood Nature. 414: 163-164. PMID 11700541 DOI: 10.1038/35102664  0.4
2001 Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science (New York, N.Y.). 294: 1704-8. PMID 11679633 DOI: 10.1126/science.1065874  0.4
2001 Qaum T, Xu Q, Joussen AM, Clemens MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. VEGF-initiated blood-retinal barrier breakdown in early diabetes. Investigative Ophthalmology & Visual Science. 42: 2408-13. PMID 11527957  0.4
2001 Zhang XQ, Takakura N, Oike Y, Inada T, Gale NW, Yancopoulos GD, Suda T. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2+ endothelial cells Blood. 98: 1028-1037. PMID 11493448 DOI: 10.1182/blood.V98.4.1028  0.4
2001 Wong AK, Alfert M, Castrillon DH, Shen Q, Holash J, Yancopoulos GD, Chin L. Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome Proceedings of the National Academy of Sciences of the United States of America. 98: 7481-7486. PMID 11404464 DOI: 10.1073/pnas.121192298  0.4
2001 Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Mañes S, Brückner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martínez C, Klein R. The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. Embo Reports. 2: 446-52. PMID 11375938 DOI: 10.1093/embo-reports/kve094  0.4
2001 Terrado J, Burgess RW, DeChiara T, Yancopoulos G, Sanes JR, Kato AC. Motoneuron survival is enhanced in the absence of neuromuscular junction formation in embryos. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3144-50. PMID 11312299  0.4
1993 Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD, Jessell TM, Alt FW. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 227-31. PMID 7678338  0.4
1992 Morrow MA, Lee G, Gillis S, Yancopoulos GD, Alt FW. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes & Development. 6: 61-70. PMID 1730410  0.4
1992 Oltz EM, Yancopoulos GD, Morrow MA, Rolink A, Lee G, Wong F, Kaplan K, Gillis S, Melchers F, Alt FW. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. The Embo Journal. 11: 2759-67. PMID 1628631  0.4
1992 Smith RK, Zimmerman K, Yancopoulos GD, Ma A, Alt FW. Transcriptional down-regulation of N-myc expression during B-cell development. Molecular and Cellular Biology. 12: 1578-84. PMID 1549113  0.48
1991 Alt FW, Rathbun G, Yancopoulos GD. DNA recombination in the brain? Current Biology : Cb. 1: 3-5. PMID 15336189  0.48
1990 Yancopoulos GD, Nolan GP, Pollock R, Prockop S, Li SC, Herzenberg LA, Alt FW. A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Molecular and Cellular Biology. 10: 1697-704. PMID 2320007  0.48
1990 Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. The Journal of Experimental Medicine. 171: 843-59. PMID 2261012  0.48
1989 Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. The Embo Journal. 8: 735-42. PMID 2785917  0.48
1989 Rathbun G, Alt FW, Yancopoulos GD. Immunology: making antigen-receptor genes. Nature. 342: 863-4. PMID 2594082 DOI: 10.1038/342863a0  0.48
1988 Yancopoulos GD, Alt FW. Reconstruction of an immune system. Science (New York, N.Y.). 241: 1581-3. PMID 3262236  0.48
1988 Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Current Topics in Microbiology and Immunology. 141: 100-9. PMID 3215042  0.48
1988 Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 54: 453-60. PMID 3135938  0.48
1988 Yancopoulos GD, Malynn BA, Alt FW. Developmentally regulated and strain-specific expression of murine VH gene families. The Journal of Experimental Medicine. 168: 417-35. PMID 3135366  0.48
1987 DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes & Development. 1: 1311-26. PMID 3322939  0.48
1987 Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science (New York, N.Y.). 238: 1079-87. PMID 3317825  0.48
1987 Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW. Expression of the immunoglobulin heavy-chain variable gene repertoire. Current Topics in Microbiology and Immunology. 135: 75-94. PMID 3107914  0.4
1987 Alt FW, Yancopoulos GD. Circular T-cell receptor gene recombination products. Nature. 327: 189-90. PMID 3106830 DOI: 10.1038/327189a0  0.48
1987 Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW. Structure and expression of the murine L-myc gene. The Embo Journal. 6: 3359-66. PMID 2828024  0.48
1986 Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F. Myc family genes: a dispersed multi-gene family. Annals of Clinical Research. 18: 284-9. PMID 3551773  0.48
1986 DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW. Structure and expression of the murine N-myc gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 1827-31. PMID 3513190  0.4
1986 Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E, Alt FW. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 324: 585-9. PMID 3491327 DOI: 10.1038/324585a0  0.48
1986 Yancopoulos GD, Blackwell TK, Suh H, Hood L, Alt FW. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 44: 251-9. PMID 3484682  0.48
1986 Yancopoulos GD, Alt FW. Regulation of the assembly and expression of variable-region genes. Annual Review of Immunology. 4: 339-68. PMID 3085692 DOI: 10.1146/annurev.iy.04.040186.002011  0.48
1986 Alt FW, Reth MG, Blackwell TK, Yancopoulos GD. Regulation of immunoglobulin variable-region gene assembly. The Mount Sinai Journal of Medicine, New York. 53: 166-9. PMID 3084957  0.48
1986 Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunological Reviews. 89: 5-30. PMID 3081433  0.48
1986 Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P. The human myc gene family. Cold Spring Harbor Symposia On Quantitative Biology. 51: 931-41. PMID 3034500  0.48
1986 Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. The Embo Journal. 5: 3259-66. PMID 3028778  0.4
1985 Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP, Alt FW. N-myc can cooperate with ras to transform normal cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 82: 5455-9. PMID 3860871 DOI: 10.1073/pnas.82.16.5455  0.4
1985 Yancopoulos GD, Alt FW. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 40: 271-81. PMID 2578321  0.48
1984 Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 311: 752-5. PMID 6092963 DOI: 10.1038/311752a0  0.4
1984 Yancopoulos GD, Desiderio SV, Paskind M, Kearney JF, Baltimore D, Alt FW. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. 311: 727-33. PMID 6092962 DOI: 10.1038/311727a0  0.4
1984 Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D. Ordered rearrangement of immunoglobulin heavy chain variable region segments. The Embo Journal. 3: 1209-19. PMID 6086308  0.48
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