| Year |
Citation |
Score |
| 2023 |
Cao X, Li T, Xu B, Ding K, Li W, Shen B, Chu M, Zhu D, Rui L, Shang Z, Li X, Wang Y, Zheng S, Alitalo K, Liu G, et al. Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 37317851 DOI: 10.1161/ATVBAHA.122.318860 |
0.32 |
|
| 2023 |
Li Z, Antila S, Nurmi H, Chilov D, Korhonen EA, Fang S, Karaman S, Engelhardt B, Alitalo K. Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation. Science Immunology. 8: eabq0375. PMID 37058549 DOI: 10.1126/sciimmunol.abq0375 |
0.358 |
|
| 2023 |
Chiang IKN, Graus MS, Kirschnick N, Davidson T, Luu W, Harwood R, Jiang K, Li B, Wong YY, Moustaqil M, Lesieur E, Skoczylas R, Kouskoff V, Kazenwadel J, Arriola-Martinez L, ... ... Alitalo K, et al. The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. The Embo Journal. e109032. PMID 36715213 DOI: 10.15252/embj.2021109032 |
0.315 |
|
| 2022 |
Leppäpuska IM, Hartiala P, Suominen S, Suominen E, Kaartinen I, Mäki M, Seppänen M, Kiiski J, Viitanen T, Lahdenperä O, Vuolanto A, Alitalo K, Saarikko AM. Phase 1 Lymfactin® Study: 24-month Efficacy and Safety Results of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema. Journal of Plastic, Reconstructive & Aesthetic Surgery : Jpras. PMID 36151039 DOI: 10.1016/j.bjps.2022.08.011 |
0.321 |
|
| 2022 |
Korhonen EA, Murtomäki A, Jha SK, Anisimov A, Pink A, Zhang Y, Stritt S, Liaqat I, Stanczuk L, Alderfer L, Sun Z, Kapiainen E, Singh A, Sultan I, Lantta A, ... ... Alitalo K, et al. Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell surface expression. The Journal of Clinical Investigation. PMID 35763346 DOI: 10.1172/JCI155478 |
0.377 |
|
| 2022 |
Karaman S, Paavonsalo S, Heinolainen K, Lackman MH, Ranta A, Hemanthakumar KA, Kubota Y, Alitalo K. Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. The Journal of Experimental Medicine. 219. PMID 35050301 DOI: 10.1084/jem.20210565 |
0.375 |
|
| 2020 |
Lähde M, Heino S, Högström J, Kaijalainen S, Anisimov A, Flanagan D, Kallio P, Leppänen VM, Ristimäki A, Ritvos O, Wu K, Tammela T, Hodder M, Sansom OJ, Alitalo K. Expression of R-spondin1 in Apc Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling. Gastroenterology. PMID 32941878 DOI: 10.1053/J.Gastro.2020.09.011 |
0.316 |
|
| 2020 |
Leppänen VM, Brouillard P, Korhonen EA, Sipilä T, Jha SK, Revencu N, Labarque V, Fastré E, Schlögel M, Ravoet M, Singer A, Luzzatto C, Angelone D, Crichiutti G, D'Elia A, ... ... Alitalo K, et al. Characterization of mutations associated with primary lymphedema. Science Translational Medicine. 12. PMID 32908006 DOI: 10.1126/Scitranslmed.Aax8013 |
0.407 |
|
| 2020 |
Fang S, Chen S, Nurmi H, Leppänen VM, Jeltsch M, Scadden DT, Silberstein L, Mikkola H, Alitalo K. VEGF-C Protects the Integrity of Bone Marrow Perivascular Niche. Blood. PMID 32842144 DOI: 10.1182/Blood.2020005699 |
0.441 |
|
| 2020 |
Hong SP, Yang MJ, Cho H, Park I, Bae H, Choe K, Suh SH, Adams RH, Alitalo K, Lim D, Koh GY. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nature Communications. 11: 4102. PMID 32796823 DOI: 10.1038/S41467-020-17886-Y |
0.411 |
|
| 2020 |
Zhang Y, Cedervall J, Hamidi A, Herre M, Viitaniemi K, D'Amico G, Miao Z, Valsala Madhavan Unnithan R, Vaccaro A, van Hooren L, Georganaki M, Thulin Å, Qiao Q, Andrae J, Siegbahn A, ... ... Alitalo K, et al. Platelet-specific PDGFB ablation impairs tumor vessel integrity and promotes metastasis. Cancer Research. PMID 32586981 DOI: 10.1158/0008-5472.Can-19-3533 |
0.351 |
|
| 2020 |
Maisel K, Hrusch CL, Medellin JEG, Potin L, Chapel DB, Nurmi H, Camacho DF, Gleyzer R, Alitalo K, Sperling AI, Swartz MA. Pro-lymphangiogenic VEGFR-3 signaling modulates memory T cell responses in allergic airway inflammation. Mucosal Immunology. PMID 32518367 DOI: 10.1038/S41385-020-0308-4 |
0.303 |
|
| 2020 |
Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Castillo SD, Brouillard P, Libbrecht L, Saur D, Graupera M, Alitalo K, Boon L, Vikkula M, Mäkinen T. Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation. Nature Communications. 11: 2869. PMID 32513927 DOI: 10.1038/S41467-020-16496-Y |
0.468 |
|
| 2020 |
Houssari M, Dumesnil A, Tardif V, Kivelä R, Pizzinat N, Boukhalfa I, Godefroy D, Schapman D, Hemanthakumar KA, Bizou M, Henry JP, Renet S, Riou G, Rondeaux J, Anouar Y, ... ... Alitalo K, et al. Lymphatic and Immune Cell Cross-Talk Regulates Cardiac Recovery After Experimental Myocardial Infarction. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314370. PMID 32404007 DOI: 10.1161/Atvbaha.120.314370 |
0.38 |
|
| 2020 |
Kallio P, Jokinen E, Högström J, Das S, Heino S, Lähde M, Brodkin J, Korhonen EA, Alitalo K. Blocking angiopoietin-2 promotes vascular damage and growth inhibition in mouse tumors treated with small doses of radiation. Cancer Research. PMID 32312835 DOI: 10.1158/0008-5472.Can-20-0497 |
0.366 |
|
| 2020 |
Lähteenvuo J, Hätinen OP, Kuivanen A, Huusko J, Paananen J, Lähteenvuo M, Nurro J, Hedman M, Hartikainen J, Laham-Karam N, Mäkinen P, Räsänen M, Alitalo K, Rosenzweig A, Ylä-Herttuala S. Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32243833 DOI: 10.1016/J.Ymthe.2020.03.011 |
0.343 |
|
| 2020 |
Li Z, Korhonen EA, Merlini A, Strauss J, Wihuri E, Nurmi H, Antila S, Paech J, Deutsch U, Engelhardt B, Chintharlapalli S, Koh GY, Flügel A, Alitalo K. Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS. The Journal of Clinical Investigation. PMID 32149735 DOI: 10.1172/Jci130308 |
0.382 |
|
| 2020 |
Song E, Mao T, Dong H, Boisserand LSB, Antila S, Bosenberg M, Alitalo K, Thomas JL, Iwasaki A. VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours. Nature. PMID 31942068 DOI: 10.1038/S41586-019-1912-X |
0.372 |
|
| 2019 |
Tiainen L, Korhonen EA, Leppänen VM, Luukkaala T, Hämäläinen M, Tanner M, Lahdenperä O, Vihinen P, Jukkola A, Karihtala P, Aho S, Moilanen E, Alitalo K, Kellokumpu-Lehtinen PL. High baseline Tie1 level predicts poor survival in metastatic breast cancer. Bmc Cancer. 19: 732. PMID 31340773 DOI: 10.1186/S12885-019-5959-8 |
0.355 |
|
| 2019 |
Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman UH, Alitalo K, Jeltsch M. KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D. Elife. 8. PMID 31099754 DOI: 10.7554/Elife.44478 |
0.453 |
|
| 2019 |
Kivelä R, Hemanthakumar KA, Vaparanta K, Robciuc M, Izumiya Y, Kidoya H, Takakura N, Peng X, Sawyer DB, Elenius K, Walsh K, Alitalo K. Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2 -Mediated Paracrine Signaling. Circulation. PMID 30922063 DOI: 10.1161/Circulationaha.118.036099 |
0.356 |
|
| 2019 |
Suh SH, Choe K, Hong SP, Jeong SH, Mäkinen T, Kim KS, Alitalo K, Surh CD, Koh GY, Song JH. Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages. Embo Reports. PMID 30783017 DOI: 10.15252/Embr.201846927 |
0.344 |
|
| 2019 |
Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman U, Alitalo K, Jeltsch M. Author response: KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D Elife. DOI: 10.7554/Elife.44478.034 |
0.368 |
|
| 2019 |
Elmadani M, Szabo Z, Raatikainen S, Ruizhu L, Alakoski T, Piuhola J, Yrjolä R, Miinalainen I, Åström P, Alitalo K, Tehunen O, Magga J, Kerkelä R. Abstract 731: Sorafenib Induces Cardiotoxicity via Damage to Cardiac Endothelial Cells Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.731 |
0.372 |
|
| 2018 |
Durré T, Morfoisse F, Erpicum C, Ebroin M, Blacher S, García-Caballero M, Deroanne C, Louis T, Balsat C, Van de Velde M, Kaijalainen S, Kridelka F, Engelholm L, Struman I, Alitalo K, et al. uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis. Nature Communications. 9: 5178. PMID 30518756 DOI: 10.1038/S41467-018-07514-1 |
0.479 |
|
| 2018 |
Onions K, Gamez M, Buckner NR, Baker SL, Betteridge KB, Desideri S, Dallyn BP, Ramnath R, Neal CR, Farmer LK, Mathieson PW, Gnudi L, Alitalo K, Bates DO, Salmon AHJ, et al. VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy. Diabetes. PMID 30389746 DOI: 10.2337/Db18-0045 |
0.386 |
|
| 2018 |
Lorenz L, Axnick J, Buschmann T, Henning C, Urner S, Fang S, Nurmi H, Eichhorst N, Holtmeier R, Bódis K, Hwang JH, Müssig K, Eberhard D, Stypmann J, Kuss O, ... ... Alitalo K, et al. Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival. Nature. PMID 30258227 DOI: 10.1038/S41586-018-0522-3 |
0.398 |
|
| 2018 |
Karaman S, Nurmi H, Antila S, Alitalo K. Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery. Methods in Molecular Biology (Clifton, N.J.). 1846: 291-300. PMID 30242767 DOI: 10.1007/978-1-4939-8712-2_19 |
0.402 |
|
| 2018 |
Högström J, Heino S, Kallio P, Lähde M, Leppänen VM, Balboa D, Wiener Z, Alitalo K. Transcription factor PROX1 suppresses Notch pathway activation via the nucleosome remodeling and deacetylase complex in colorectal cancer stem-like cells. Cancer Research. PMID 30154153 DOI: 10.1158/0008-5472.Can-18-0451 |
0.352 |
|
| 2018 |
Karaman S, Leppänen VM, Alitalo K. Vascular endothelial growth factor signaling in development and disease. Development (Cambridge, England). 145. PMID 30030240 DOI: 10.1242/Dev.151019 |
0.475 |
|
| 2018 |
Hytönen JP, Taavitsainen J, Laitinen JTT, Partanen A, Alitalo K, Leppänen O, Ylä-Herttuala S. Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits. Journal of Molecular and Cellular Cardiology. 121: 145-154. PMID 30003882 DOI: 10.1016/J.Yjmcc.2018.07.007 |
0.417 |
|
| 2018 |
Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, et al. PROX1 is a transcriptional regulator of MMP14. Scientific Reports. 8: 9531. PMID 29934628 DOI: 10.1038/S41598-018-27739-W |
0.342 |
|
| 2018 |
Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, et al. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. PMID 29766399 DOI: 10.1007/S10456-018-9613-X |
0.374 |
|
| 2018 |
Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo K, Mäkinen T. Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms. Nature Communications. 9: 1296. PMID 29615616 DOI: 10.1038/S41467-018-03692-0 |
0.437 |
|
| 2018 |
Högström J, Heino S, Kallio P, Lähde M, Leppänen V, Kaijalainen S, Balboa D, Otonkoski T, Robine S, Wiener Z, Alitalo K. Abstract 1143: Prox1 and Notch mark distinct colorectal cancer stem cell populations Cancer Research. 78: 1143-1143. DOI: 10.1158/1538-7445.Am2018-1143 |
0.314 |
|
| 2018 |
Rasanen MOH, Amudhala Hemanthakumar K, Paech JB, Robciuc MR, Ramanujam D, Lahteenvuo JB, Engelhardt S, Kivela R, Alitalo K. 234Models for VEGF-B induced physiological and pathological cardiac hypertrophy Cardiovascular Research. 114: S60-S60. DOI: 10.1093/Cvr/Cvy060.165 |
0.336 |
|
| 2017 |
Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, ... Alitalo K, et al. Development and plasticity of meningeal lymphatic vessels. The Journal of Experimental Medicine. PMID 29141865 DOI: 10.1084/Jem.20170391 |
0.464 |
|
| 2017 |
Lohela M, Alitalo K. Fighting vessel dysmorphia to improve glioma chemotherapy. Embo Molecular Medicine. PMID 29127101 DOI: 10.15252/Emmm.201708431 |
0.375 |
|
| 2017 |
Vaahtomeri K, Karaman S, Mäkinen T, Alitalo K. Lymphangiogenesis guidance by paracrine and pericellular factors. Genes & Development. 31: 1615-1634. PMID 28947496 DOI: 10.1101/Gad.303776.117 |
0.4 |
|
| 2017 |
Jha SK, Rauniyar K, Karpanen T, Leppänen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Scientific Reports. 7: 4916. PMID 28687807 DOI: 10.1038/S41598-017-04982-1 |
0.405 |
|
| 2017 |
Nitschké M, Bell A, Karaman S, Amouzgar M, Rutkowski JM, Scherer PE, Alitalo K, McDonald DM. Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations. The American Journal of Pathology. PMID 28683257 DOI: 10.1016/J.Ajpath.2017.05.009 |
0.381 |
|
| 2017 |
Naumenko N, Huusko J, Tuomainen T, Koivumäki JT, Merentie M, Gurzeler E, Alitalo K, Kivelä R, Ylä-Herttuala S, Tavi P. Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart. Frontiers in Physiology. 8: 373. PMID 28620319 DOI: 10.3389/Fphys.2017.00373 |
0.382 |
|
| 2017 |
Saharinen P, Eklund L, Alitalo K. Therapeutic targeting of the angiopoietin-TIE pathway. Nature Reviews. Drug Discovery. PMID 28529319 DOI: 10.1038/Nrd.2016.278 |
0.435 |
|
| 2017 |
Karaman S, Alitalo K. ORAI1 Controls the Unique Adjustment of Lymphatics to Fluid Flow. Circulation Research. 120: 1373-1375. PMID 28450355 DOI: 10.1161/Circresaha.117.310917 |
0.308 |
|
| 2017 |
Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, et al. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. Embo Molecular Medicine. PMID 28438786 DOI: 10.15252/Emmm.201607341 |
0.407 |
|
| 2017 |
Leppänen VM, Saharinen P, Alitalo K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396439 DOI: 10.1073/Pnas.1616166114 |
0.346 |
|
| 2017 |
Rademakers T, van der Vorst EP, Daissormont IT, Otten JJ, Theodorou K, Theelen TL, Gijbels M, Anisimov A, Nurmi H, Lindeman JH, Schober A, Heeneman S, Alitalo K, Biessen EA. Adventitial lymphatic capillary expansion impacts on plaque T cell accumulation in atherosclerosis. Scientific Reports. 7: 45263. PMID 28349940 DOI: 10.1038/Srep45263 |
0.389 |
|
| 2017 |
Heinolainen K, Karaman S, D'Amico G, Tammela T, Sormunen R, Eklund L, Alitalo K, Zarkada G. VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling. Circulation Research. PMID 28298294 DOI: 10.1161/Circresaha.116.310477 |
0.488 |
|
| 2016 |
Chu M, Li T, Shen B, Cao X, Zhong H, Zhang L, Zhou F, Ma W, Jiang H, Xie P, Liu Z, Dong N, Xu Y, Zhao Y, Xu G, ... ... Alitalo K, et al. Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII. Elife. 5. PMID 28005008 DOI: 10.7554/Elife.21032 |
0.434 |
|
| 2016 |
Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799559 DOI: 10.1073/Pnas.1616168113 |
0.419 |
|
| 2016 |
Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, ... Alitalo K, et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. The Journal of Clinical Investigation. PMID 27548530 DOI: 10.1172/Jci84923 |
0.414 |
|
| 2016 |
Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. The Journal of Clinical Investigation. PMID 27548529 DOI: 10.1172/Jci84871 |
0.38 |
|
| 2016 |
Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. The Journal of Clinical Investigation. PMID 27525437 DOI: 10.1172/Jci79434 |
0.312 |
|
| 2016 |
Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M. Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice. Scientific Reports. 6: 31566. PMID 27511834 DOI: 10.1038/Srep31566 |
0.347 |
|
| 2016 |
Honkanen HK, Izzi V, Petäistö T, Holopainen T, Harjunen V, Pihlajaniemi T, Alitalo K, Heljasvaara R. Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors. Neoplasia (New York, N.Y.). 18: 436-46. PMID 27435926 DOI: 10.1016/J.Neo.2016.05.002 |
0.375 |
|
| 2016 |
Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K. Critical requirement of VEGF-C in transition to fetal erythropoiesis. Blood. PMID 27343251 DOI: 10.1182/Blood-2015-12-687970 |
0.466 |
|
| 2016 |
Johns SC, Yin X, Jeltsch M, Bishop JR, Schuksz M, El Ghazal R, Wilcox-Adelman SA, Alitalo K, Fuster MM. Functional Importance of a Proteoglycan Co-Receptor in Pathologic Lymphangiogenesis. Circulation Research. PMID 27225479 DOI: 10.1161/Circresaha.116.308504 |
0.464 |
|
| 2016 |
Bui HM, Enis D, Robciuc MR, Nurmi HJ, Cohen J, Chen M, Yang Y, Dhillon V, Johnson K, Zhang H, Kirkpatrick R, Traxler E, Anisimov A, Alitalo K, Kahn ML. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. The Journal of Clinical Investigation. PMID 27159393 DOI: 10.1172/Jci83967 |
0.328 |
|
| 2016 |
Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K. VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. Cell Metabolism. 23: 712-24. PMID 27076080 DOI: 10.1016/J.Cmet.2016.03.004 |
0.346 |
|
| 2016 |
Aspelund A, Robciuc MR, Karaman S, Makinen T, Alitalo K. Lymphatic System in Cardiovascular Medicine. Circulation Research. 118: 515-30. PMID 26846644 DOI: 10.1161/Circresaha.115.306544 |
0.338 |
|
| 2015 |
Heindl LM, Kaser-Eichberger A, Schlereth SL, Bock F, Regenfuss B, Reitsamer HA, McMenamin P, Lutty GA, Maruyama K, Chen L, Dana R, Kerjaschki D, Alitalo K, De Stefano ME, Junghans BM, et al. Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid? Investigative Ophthalmology & Visual Science. 56: 6709-6710. PMID 26588256 DOI: 10.1167/Iovs.15-17686 |
0.304 |
|
| 2015 |
Nurmi H, Saharinen P, Zarkada G, Zheng W, Robciuc MR, Alitalo K. VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption. Embo Molecular Medicine. 7: 1418-25. PMID 26459520 DOI: 10.15252/Emmm.201505731 |
0.447 |
|
| 2015 |
Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proceedings of the National Academy of Sciences of the United States of America. 112: 13063-8. PMID 26430242 DOI: 10.1073/Pnas.1517810112 |
0.351 |
|
| 2015 |
Tamminen K, Balboa D, Toivonen S, Pakarinen MP, Wiener Z, Alitalo K, Otonkoski T. Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. Plos One. 10: e0134551. PMID 26230325 DOI: 10.1371/Journal.Pone.0134551 |
0.304 |
|
| 2015 |
Orleth A, Mamot C, Rochlitz C, Ritschard R, Alitalo K, Christofori G, Wicki A. Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy. Journal of Drug Targeting. 1-10. PMID 26204325 DOI: 10.3109/1061186X.2015.1056189 |
0.438 |
|
| 2015 |
Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen V, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K. Therapeutic Insights to Lymphangiogenic Growth Factors Journal of Vascular Research. 52: 19-19. PMID 26043713 DOI: 10.1159/000433498 |
0.313 |
|
| 2015 |
Visuri MT, Honkonen KM, Hartiala P, Tervala TV, Halonen PJ, Junkkari H, Knuutinen N, Ylä-Herttuala S, Alitalo KK, Saarikko AM. VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study. Angiogenesis. 18: 313-26. PMID 26018927 DOI: 10.1007/s10456-015-9469-2 |
0.346 |
|
| 2015 |
Syrjälä SO, Nykänen AI, Tuuminen R, Raissadati A, Keränen MA, Arnaudova R, Krebs R, Koh GY, Alitalo K, Lemström KB. Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15: 2075-84. PMID 25932532 DOI: 10.1111/Ajt.13296 |
0.332 |
|
| 2015 |
Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, et al. State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. Circulation Research. 116: e99-132. PMID 25931450 DOI: 10.1161/Res.0000000000000054 |
0.432 |
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| 2015 |
Roukens MG, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen VM, Bos FL, Alitalo K, Schulte-Merker S, Schulte D. Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. Circulation Research. 116: 1660-9. PMID 25814692 DOI: 10.1161/Circresaha.116.304949 |
0.377 |
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| 2015 |
Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Maliniemi P, Lohi J, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala PM, Keski-Oja J, Lehti K. MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. Cancer Research. 75: 2083-94. PMID 25808867 DOI: 10.1158/0008-5472.Can-14-1923 |
0.307 |
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| 2015 |
Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T. cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Reports. PMID 25772358 DOI: 10.1016/J.Celrep.2015.02.026 |
0.465 |
|
| 2015 |
Martinez-Corral I, Ulvmar MH, Stanczuk L, Tatin F, Kizhatil K, John SW, Alitalo K, Ortega S, Makinen T. Nonvenous origin of dermal lymphatic vasculature. Circulation Research. 116: 1649-54. PMID 25737499 DOI: 10.1161/Circresaha.116.306170 |
0.437 |
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| 2015 |
Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, et al. Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans. Cell Reports. 10: 1158-72. PMID 25704818 DOI: 10.1016/J.Celrep.2015.01.049 |
0.455 |
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| 2015 |
Karaman S, Hollmén M, Robciuc MR, Alitalo A, Nurmi H, Morf B, Buschle D, Alkan HF, Ochsenbein AM, Alitalo K, Wolfrum C, Detmar M. Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet. Molecular Metabolism. 4: 93-105. PMID 25685697 DOI: 10.1016/J.Molmet.2014.11.006 |
0.344 |
|
| 2015 |
Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nature Communications. 6: 5962. PMID 25635707 DOI: 10.1038/Ncomms6962 |
0.435 |
|
| 2015 |
Zarkada G, Heinolainen K, Makinen T, Kubota Y, Alitalo K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proceedings of the National Academy of Sciences of the United States of America. 112: 761-6. PMID 25561555 DOI: 10.1073/Pnas.1423278112 |
0.481 |
|
| 2015 |
Wiener Z, Högström J, Hyvönen V, Kallio P, Heino S, Alitalo K. Abstract 2320: Prox1 marks a stem cell population that promotes tumor progression in intestinal adenomas Cancer Research. 75: 2320-2320. DOI: 10.1158/1538-7445.Am2015-2320 |
0.339 |
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| 2015 |
Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MAI, Tuuminen R, Krebs R, Anisimov A, Jeltsch M, Leppänen VM, Alitalo K, Nykänen AI, Lemström KB. Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts American Journal of Transplantation. DOI: 10.1111/Ajt.13564 |
0.388 |
|
| 2015 |
Dashkevich A, Raissadati A, Zarkada G, Alitalo K, Nykanen A, Lemström K. Lymphatic Endothelial Cell VEGFR3 Controls Cardiac Allograft Rejection The Journal of Heart and Lung Transplantation. 34: S93. DOI: 10.1016/J.Healun.2015.01.248 |
0.363 |
|
| 2014 |
Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G. The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes & Development. 28: 2175-87. PMID 25274728 DOI: 10.1101/Gad.216226.113 |
0.453 |
|
| 2014 |
Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. The Journal of Clinical Investigation. 124: 4899-914. PMID 25271623 DOI: 10.1172/Jci77483 |
0.314 |
|
| 2014 |
Wiener Z, Högström J, Hyvönen V, Band AM, Kallio P, Holopainen T, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K. Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. Cell Reports. 8: 1943-56. PMID 25242330 DOI: 10.1016/J.Celrep.2014.08.034 |
0.347 |
|
| 2014 |
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, Rissanen TT, André H, Pereira T, Poellinger L, Alitalo K, Ylä-Herttuala S. HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery. European Journal of Clinical Investigation. 44: 989-99. PMID 25208310 DOI: 10.1111/Eci.12333 |
0.301 |
|
| 2014 |
Dijkstra MH, Pirinen E, Huusko J, Kivelä R, Schenkwein D, Alitalo K, Ylä-Herttuala S. Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice. Scientific Reports. 4: 6238. PMID 25168313 DOI: 10.1038/Srep06238 |
0.36 |
|
| 2014 |
Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. The Journal of Clinical Investigation. 124: 3975-86. PMID 25061878 DOI: 10.1172/Jci75395 |
0.501 |
|
| 2014 |
Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. The Journal of Clinical Investigation. 124: 3960-74. PMID 25061877 DOI: 10.1172/Jci75392 |
0.44 |
|
| 2014 |
Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes & Development. 28: 1592-603. PMID 25030698 DOI: 10.1101/Gad.237677.114 |
0.436 |
|
| 2014 |
Bry M, Kivelä R, Leppänen VM, Alitalo K. Vascular endothelial growth factor-B in physiology and disease. Physiological Reviews. 94: 779-94. PMID 24987005 DOI: 10.1152/Physrev.00028.2013 |
0.457 |
|
| 2014 |
Vuorio T, Nurmi H, Moulton K, Kurkipuro J, Robciuc MR, Ohman M, Heinonen SE, Samaranayake H, Heikura T, Alitalo K, Ylä-Herttuala S. Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1162-70. PMID 24723556 DOI: 10.1161/Atvbaha.114.302528 |
0.329 |
|
| 2014 |
Zheng W, Aspelund A, Alitalo K. Lymphangiogenic factors, mechanisms, and applications. The Journal of Clinical Investigation. 124: 878-87. PMID 24590272 DOI: 10.1172/Jci71603 |
0.35 |
|
| 2014 |
Jeltsch M, Jha SK, Tvorogov D, Anisimov A, Leppänen VM, Holopainen T, Kivelä R, Ortega S, Kärpanen T, Alitalo K. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation. 129: 1962-71. PMID 24552833 DOI: 10.1161/Circulationaha.113.002779 |
0.438 |
|
| 2014 |
Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, ... ... Alitalo K, et al. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. Embo Molecular Medicine. 6: 307-21. PMID 24448490 DOI: 10.1002/Emmm.201303147 |
0.41 |
|
| 2014 |
D'Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. The Journal of Clinical Investigation. 124: 824-34. PMID 24430181 DOI: 10.1172/Jci68897 |
0.454 |
|
| 2014 |
Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald DM. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circulation Research. 114: 806-22. PMID 24429550 DOI: 10.1161/Circresaha.114.303119 |
0.384 |
|
| 2014 |
Nieminen T, Toivanen PI, Rintanen N, Heikura T, Jauhiainen S, Airenne KJ, Alitalo K, Marjomäki V, Ylä-Herttuala S. The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features. Biochimica Et Biophysica Acta. 1840: 454-63. PMID 24112971 DOI: 10.1016/J.Bbagen.2013.10.005 |
0.454 |
|
| 2014 |
Wiener Z, Hyvönen V, Högström J, Holopainen T, Band A, Kallio P, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K. Abstract 1908: The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth Cancer Research. 74: 1908-1908. DOI: 10.1158/1538-7445.Am2014-1908 |
0.355 |
|
| 2014 |
Raissadati A, Tuuminen R, Dashkevich A, Krebs R, Arnaudova R, Rouvinen E, Alitalo K, Nykanen A, Lemstrom K. Transgenic Overexpression of Cardiac-Specific Vascular Endothelial Growth Factor B Exacerbates Ischemia Reperfusion Injury in Rat Cardiac Grafts. Transplantation. 98: 352-353. DOI: 10.1097/00007890-201407151-01141 |
0.354 |
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| 2014 |
Dashkevich A, Syrjälä SO, Keränen MA, Krebs R, Nykänen AI, Alitalo K, Lemström KB. Perioperative single-dose VEGF-C/D inhibitor enhances cardiac allograft survival and prevents chronic rejection by regulating lymphatic endothelial cell activation Thoracic and Cardiovascular Surgeon. 62. DOI: 10.1055/S-0034-1367258 |
0.402 |
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| 2014 |
Dashkevich A, Syrjälä S, Keränen M, Tuuminen R, Raissadati A, Krebs R, Alitalo K, Nykänen A, Lemström K. Donor Single-dose Treatment with VEGFR-3 Antibody Reduces Acute Alloimmune Response by Targeting Lymphatic Endothelial Cell Activation Journal of Heart and Lung Transplantation. 33. DOI: 10.1016/J.Healun.2014.01.442 |
0.342 |
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| 2013 |
Jeltsch M, Leppänen VM, Saharinen P, Alitalo K. Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harbor Perspectives in Biology. 5. PMID 24003209 DOI: 10.1101/Cshperspect.A009183 |
0.461 |
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| 2013 |
Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K. Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12960-5. PMID 23878260 DOI: 10.1073/Pnas.1301415110 |
0.373 |
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| 2013 |
Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. Embo Molecular Medicine. 5: 1415-30. PMID 23853117 DOI: 10.1002/Emmm.201302618 |
0.468 |
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| 2013 |
Anisimov A, Leppänen VM, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T, Kaijalainen S, Alitalo K. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Science Signaling. 6: ra52. PMID 23821770 DOI: 10.1126/Scisignal.2003905 |
0.437 |
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| 2013 |
Gaál EI, Tammela T, Anisimov A, Marbacher S, Honkanen P, Zarkada G, Leppänen VM, Tatlisumak T, Hernesniemi J, Niemelä M, Alitalo K. Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. Blood. 122: 658-65. PMID 23803710 DOI: 10.1182/Blood-2012-07-441527 |
0.44 |
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| 2013 |
Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Molecular and Cellular Biology. 33: 3321-9. PMID 23775121 DOI: 10.1128/Mcb.00432-13 |
0.326 |
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| 2013 |
Wiig H, Schröder A, Neuhofer W, Jantsch J, Kopp C, Karlsen TV, Boschmann M, Goss J, Bry M, Rakova N, Dahlmann A, Brenner S, Tenstad O, Nurmi H, Mervaala E, ... ... Alitalo K, et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. The Journal of Clinical Investigation. 123: 2803-15. PMID 23722907 DOI: 10.1172/Jci60113 |
0.31 |
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| 2013 |
Hamm A, Veschini L, Takeda Y, Costa S, Delamarre E, Squadrito ML, Henze AT, Wenes M, Serneels J, Pucci F, Roncal C, Anisimov A, Alitalo K, De Palma M, Mazzone M. PHD2 regulates arteriogenic macrophages through TIE2 signalling. Embo Molecular Medicine. 5: 843-57. PMID 23616286 DOI: 10.1002/Emmm.201302695 |
0.337 |
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| 2013 |
Eklund L, Bry M, Alitalo K. Mouse models for studying angiogenesis and lymphangiogenesis in cancer. Molecular Oncology. 7: 259-82. PMID 23522958 DOI: 10.1016/J.Molonc.2013.02.007 |
0.418 |
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| 2013 |
Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K. Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cellular and Molecular Life Sciences : Cmls. 70: 1779-92. PMID 23479133 DOI: 10.1007/S00018-013-1312-6 |
0.454 |
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| 2013 |
Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, Gerhardt H, Alitalo K, Lawson ND. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development (Cambridge, England). 140: 1497-506. PMID 23462469 DOI: 10.1242/Dev.084152 |
0.481 |
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| 2013 |
Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM. Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. The American Journal of Pathology. 182: 1434-47. PMID 23391392 DOI: 10.1016/J.Ajpath.2012.12.003 |
0.327 |
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| 2013 |
Anisimov A, Tvorogov D, Alitalo A, Leppänen VM, An Y, Han EC, Orsenigo F, Gaál EI, Holopainen T, Koh YJ, Tammela T, Korpisalo P, Keskitalo S, Jeltsch M, Ylä-Herttuala S, ... ... Alitalo K, et al. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation. 127: 424-34. PMID 23357661 DOI: 10.1161/Circulationaha.112.127472 |
0.459 |
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| 2013 |
Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. The Embo Journal. 32: 629-44. PMID 23299940 DOI: 10.1038/Emboj.2012.340 |
0.465 |
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| 2013 |
Markhus CE, Karlsen TV, Wagner M, Wagner M, Svendsen ØS, Tenstad O, Alitalo K, Wiig H. Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 266-74. PMID 23288156 DOI: 10.1161/Atvbaha.112.300384 |
0.409 |
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| 2013 |
Partanen TA, Vuola P, Jauhiainen S, Lohi J, Salminen P, Pitkäranta A, Häkkinen SK, Honkonen K, Alitalo K, Ylä-Herttuala S. Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations. Angiogenesis. 16: 137-46. PMID 22961441 DOI: 10.1007/S10456-012-9305-X |
0.489 |
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| 2013 |
Alitalo K, VanHook AM. Science signaling Podcast: 2 july 2013 Science Signaling. 6. DOI: 10.1126/Scisignal.2004435 |
0.451 |
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| 2013 |
Dashkevich A, Syrjälä SO, Keränen MA, Tuuminen R, Krebs R, Nykänen AI, Alitalo K, Lemström KB. Intracoronary Treatment with VEGF-C/D Inhibitor Enhances Cardiac Allograft Survival and Prevents Chronic Rejection by Regulating Lymphatic Endothelial Cell Activation Journal of Heart and Lung Transplantation. 32. DOI: 10.1016/J.Healun.2013.01.883 |
0.4 |
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| 2013 |
Syrjälä S, Dashkevich A, Nykänen A, Leow C, Alitalo K, Lemström K. Systemic Inhibition of Angiopoietin-2 Prevents Endothelial Activation, and Acute Rejection in Rat Cardiac Allografts The Journal of Heart and Lung Transplantation. 32: S136. DOI: 10.1016/J.Healun.2013.01.304 |
0.335 |
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| 2012 |
Huusko J, Lottonen L, Merentie M, Gurzeler E, Anisimov A, Miyanohara A, Alitalo K, Tavi P, Ylä-Herttuala S. AAV9-mediated VEGF-B gene transfer improves systolic function in progressive left ventricular hypertrophy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2212-21. PMID 23089731 DOI: 10.1038/Mt.2012.145 |
0.415 |
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| 2012 |
Leite de Oliveira R, Deschoemaeker S, Henze AT, Debackere K, Finisguerra V, Takeda Y, Roncal C, Dettori D, Tack E, Jönsson Y, Veschini L, Peeters A, Anisimov A, Hofmann M, Alitalo K, et al. Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. Cancer Cell. 22: 263-77. PMID 22897855 DOI: 10.1016/J.Ccr.2012.06.028 |
0.336 |
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| 2012 |
Larrieu-Lahargue F, Welm AL, Bouchecareilh M, Alitalo K, Li DY, Bikfalvi A, Auguste P. Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. Plos One. 7: e39540. PMID 22761819 DOI: 10.1371/Journal.Pone.0039540 |
0.487 |
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| 2012 |
Mirza M, Pang MF, Zaini MA, Haiko P, Tammela T, Alitalo K, Philipson L, Fuxe J, Sollerbrant K. Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. Plos One. 7: e37523. PMID 22624044 DOI: 10.1371/Journal.Pone.0037523 |
0.443 |
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| 2012 |
Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Research. 72: 3512-21. PMID 22593188 DOI: 10.1158/0008-5472.Can-11-1070 |
0.445 |
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| 2012 |
Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, Schrödter K, Zimmermann A, Helfrich I, Rundqvist H, Theegarten D, Anhenn O, Orian-Rousseau V, Johnson RS, Alitalo K, Fischer JW, et al. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood. 119: 5931-42. PMID 22547584 DOI: 10.1182/Blood-2011-12-396895 |
0.363 |
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| 2012 |
Martínez-Corral I, Olmeda D, Diéguez-Hurtado R, Tammela T, Alitalo K, Ortega S. In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 6223-8. PMID 22474390 DOI: 10.1073/Pnas.1115542109 |
0.38 |
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| 2012 |
Pietilä R, Nätynki M, Tammela T, Kangas J, Pulkki KH, Limaye N, Vikkula M, Koh GY, Saharinen P, Alitalo K, Eklund L. Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses. Journal of Cell Science. 125: 2212-23. PMID 22357955 DOI: 10.1242/Jcs.098020 |
0.366 |
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| 2012 |
Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, ... Alitalo K, et al. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. Journal of the National Cancer Institute. 104: 461-75. PMID 22343031 DOI: 10.1093/Jnci/Djs009 |
0.448 |
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| 2012 |
Sopo M, Anttila M, Sallinen H, Tuppurainen L, Laurema A, Laidinen S, Hamalainen K, Tuunanen P, Koponen JK, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma. International Journal of Cancer. Journal International Du Cancer. 131: 2394-401. PMID 22336998 DOI: 10.1002/Ijc.27495 |
0.33 |
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| 2012 |
Weltner J, Anisimov A, Alitalo K, Otonkoski T, Trokovic R. Induced pluripotent stem cell clones reprogrammed via recombinant adeno-associated virus-mediated transduction contain integrated vector sequences. Journal of Virology. 86: 4463-7. PMID 22301147 DOI: 10.1128/Jvi.06302-11 |
0.307 |
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| 2012 |
Brozzo MS, Bjeli? S, Kisko K, Schleier T, Leppänen VM, Alitalo K, Winkler FK, Ballmer-Hofer K. Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood. 119: 1781-8. PMID 22207738 DOI: 10.1182/Blood-2011-11-390922 |
0.381 |
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| 2012 |
Pekkonen P, Cheng F, Sugiyama N, Henderson S, Rantanen V, Aavikko M, Hautaniemi S, Aaltonen L, Boshoff C, Alitalo K, Lehti K, Ojala PM. Abstract 2976: KSHV-initiated Notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition Cancer Research. 72: 2976-2976. DOI: 10.1158/1538-7445.Am2012-2976 |
0.384 |
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| 2012 |
Alitalo K. Growth factors and inhibitors of tumor angiogenesis and lymphatic metastasis Vascular Pharmacology. 56: 306-307. DOI: 10.1016/J.Vph.2011.08.006 |
0.36 |
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| 2011 |
Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, ... Alitalo K, et al. KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host & Microbe. 10: 577-90. PMID 22177562 DOI: 10.1016/J.Chom.2011.10.011 |
0.38 |
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| 2011 |
Alitalo K. The lymphatic vasculature in disease. Nature Medicine. 17: 1371-80. PMID 22064427 DOI: 10.1038/Nm.2545 |
0.325 |
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| 2011 |
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, ... ... Alitalo K, et al. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature. 479: 122-6. PMID 21983962 DOI: 10.1038/Nature10507 |
0.306 |
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| 2011 |
Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, ... ... Alitalo K, et al. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nature Cell Biology. 13: 1202-13. PMID 21909098 DOI: 10.1038/Ncb2331 |
0.495 |
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| 2011 |
Piltonen M, Planken A, Leskelä O, Myöhänen TT, Hänninen AL, Auvinen P, Alitalo K, Andressoo JO, Saarma M, Männistö PT. Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo. Neuroscience. 192: 550-63. PMID 21767614 DOI: 10.1016/J.Neuroscience.2011.06.084 |
0.469 |
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| 2011 |
Kisko K, Brozzo MS, Missimer J, Schleier T, Menzel A, Leppänen VM, Alitalo K, Walzthoeni T, Aebersold R, Ballmer-Hofer K. Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2980-6. PMID 21613573 DOI: 10.1096/Fj.11-185397 |
0.376 |
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| 2011 |
Saharinen P, Alitalo K. The yin, the yang, and the angiopoietin-1. The Journal of Clinical Investigation. 121: 2157-9. PMID 21606600 DOI: 10.1172/Jci58196 |
0.424 |
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| 2011 |
Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood. 118: 1154-62. PMID 21566091 DOI: 10.1182/Blood-2010-11-317800 |
0.494 |
|
| 2011 |
Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, ... ... Alitalo K, et al. Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes & Development. 25: 831-44. PMID 21498572 DOI: 10.1101/Gad.615311 |
0.499 |
|
| 2011 |
Saharinen P, Eklund L, Pulkki K, Bono P, Alitalo K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends in Molecular Medicine. 17: 347-62. PMID 21481637 DOI: 10.1016/J.Molmed.2011.01.015 |
0.462 |
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| 2011 |
Yang H, Kim C, Kim MJ, Schwendener RA, Alitalo K, Heston W, Kim I, Kim WJ, Koh GY. Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Molecular Cancer. 10: 36. PMID 21481239 DOI: 10.1186/1476-4598-10-36 |
0.403 |
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| 2011 |
Holopainen T, Bry M, Alitalo K, Saaristo A. Perspectives on lymphangiogenesis and angiogenesis in cancer. Journal of Surgical Oncology. 103: 484-8. PMID 21480240 DOI: 10.1002/Jso.21808 |
0.397 |
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| 2011 |
Norrmén C, Tammela T, Petrova TV, Alitalo K. Biological basis of therapeutic lymphangiogenesis. Circulation. 123: 1335-51. PMID 21444892 DOI: 10.1161/Circulationaha.107.704098 |
0.35 |
|
| 2011 |
Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, ... ... Alitalo K, et al. Copy number variation and selection during reprogramming to pluripotency. Nature. 471: 58-62. PMID 21368824 DOI: 10.1038/Nature09871 |
0.312 |
|
| 2011 |
Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, Antsiferova M, Werner S, Alitalo K, Detmar M. An important role of lymphatic vessel activation in limiting acute inflammation. Blood. 117: 4667-78. PMID 21364190 DOI: 10.1182/Blood-2010-10-316356 |
0.422 |
|
| 2011 |
Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y. CKIα ablation highlights a critical role for p53 in invasiveness control. Nature. 470: 409-13. PMID 21331045 DOI: 10.1038/Nature09673 |
0.302 |
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| 2011 |
Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M. Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1049-58. PMID 21311040 DOI: 10.1161/Atvbaha.110.222356 |
0.463 |
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| 2011 |
Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I, Alitalo K. Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Science Translational Medicine. 3: 69ra11. PMID 21307301 DOI: 10.1126/Scitranslmed.3001699 |
0.332 |
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| 2011 |
Lähteenvuo M, Honkonen K, Tervala T, Tammela T, Suominen E, Lähteenvuo J, Kholová I, Alitalo K, Ylä-Herttuala S, Saaristo A. Growth factor therapy and autologous lymph node transfer in lymphedema. Circulation. 123: 613-20. PMID 21282502 DOI: 10.1161/Circulationaha.110.965384 |
0.301 |
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| 2011 |
Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood. 117: 1507-15. PMID 21148085 DOI: 10.1182/Blood-2010-08-301549 |
0.436 |
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| 2011 |
Gjini E, Hekking LH, Küchler A, Saharinen P, Wienholds E, Post JA, Alitalo K, Schulte-Merker S. Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity Dmm Disease Models and Mechanisms. 4: 57-66. PMID 21045210 DOI: 10.1242/Dev.064220 |
0.375 |
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| 2011 |
Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice Cancer Gene Therapy. 18: 100-109. PMID 20865022 DOI: 10.1038/Cgt.2010.56 |
0.389 |
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| 2011 |
Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I, Alitalo K. Abstract LB-422: Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-422 |
0.336 |
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| 2011 |
Wicki A, Rochlitz C, Orleth A, Ritschard R, Alitalo K, Herrmann R, Christofori G, Mamot C. Abstract 3634: Selective targeting of tumor-associated angiogenic tip and stalk cells with immunoliposomes (ILs) directed against VEGFR-2 and VEGFR-3 expressing cells Cancer Research. 71: 3634-3634. DOI: 10.1158/1538-7445.Am2011-3634 |
0.44 |
|
| 2010 |
Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell. 18: 630-40. PMID 21130043 DOI: 10.1016/J.Ccr.2010.11.001 |
0.401 |
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| 2010 |
Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg CE, Lorentz P, Jeltsch M, Alitalo K, Eriksson U, Christofori G, Pietras K. Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. Plos One. 5: e14109. PMID 21124841 DOI: 10.1371/Journal.Pone.0014109 |
0.466 |
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| 2010 |
Kim M, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K, Kim I, Koh GY. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche Cancer Research. 70: 10411-10421. PMID 21056990 DOI: 10.1158/0008-5472.Can-10-2591 |
0.354 |
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| 2010 |
Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, ... ... Alitalo K, et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation. 122: 1725-33. PMID 20937974 DOI: 10.1161/Circulationaha.110.957332 |
0.445 |
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| 2010 |
Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J, Lehti K. Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation Cancer Research. 70: 7851-7861. PMID 20876804 DOI: 10.1158/0008-5472.Can-10-1223 |
0.327 |
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| 2010 |
Huggenberger R, Ullmann S, Proulx ST, Pytowski B, Alitalo K, Detmar M. Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation Journal of Experimental Medicine. 207: 2255-2269. PMID 20837699 DOI: 10.1084/Jem.20100559 |
0.404 |
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| 2010 |
Zhou F, Chang Z, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z, He Y. Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. The American Journal of Pathology. 177: 2124-33. PMID 20724596 DOI: 10.2353/Ajpath.2010.091301 |
0.37 |
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| 2010 |
Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Ren B, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, ... ... Alitalo K, et al. Role of synectin in lymphatic development in zebrafish and frogs. Blood. 116: 3356-66. PMID 20631376 DOI: 10.1182/Blood-2009-11-254557 |
0.457 |
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| 2010 |
Kim H, Nguyen VP, Petrova TV, Cruz M, Alitalo K, Dumont DJ. Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature Bmc Developmental Biology. 10. PMID 20584329 DOI: 10.1186/1471-213X-10-72 |
0.465 |
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| 2010 |
Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development Genes and Development. 24: 875-880. PMID 20439428 DOI: 10.1101/Gad.565010 |
0.455 |
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| 2010 |
Saharinen P, Bry M, Alitalo K. How do angiopoietins Tie in with vascular endothelial growth factors? Current Opinion in Hematology. 17: 198-205. PMID 20375888 DOI: 10.1097/Moh.0B013E3283386673 |
0.492 |
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| 2010 |
Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB. Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts. Circulation. 121: 1413-22. PMID 20231530 DOI: 10.1161/Circulationaha.109.910703 |
0.461 |
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| 2010 |
Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L. VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts Embo Journal. 29: 1377-1388. PMID 20224550 DOI: 10.1038/Emboj.2010.30 |
0.482 |
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| 2010 |
Tammela T, Alitalo K. Lymphangiogenesis: Molecular Mechanisms and Future Promise Cell. 140: 460-476. PMID 20178740 DOI: 10.1016/J.Cell.2010.01.045 |
0.309 |
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| 2010 |
Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K. Structural determinants of growth factor binding and specificity by VEGF receptor 2 Proceedings of the National Academy of Sciences of the United States of America. 107: 2425-2430. PMID 20145116 DOI: 10.1073/Pnas.0914318107 |
0.448 |
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| 2010 |
Uhrin P, Zaujec J, Breuss JM, Olcaydu D, Chrenek P, Stockinger H, Fuertbauer E, Moser M, Haiko P, Fässler R, Alitalo K, Binder BR, Kerjaschki D. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 115: 3997-4005. PMID 20110424 DOI: 10.1182/Blood-2009-04-216069 |
0.317 |
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| 2010 |
Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, et al. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. The Journal of Cell Biology. 188: 115-30. PMID 20065093 DOI: 10.1083/Jcb.200903137 |
0.491 |
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| 2010 |
Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV. Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity Blood. 115: 906-909. PMID 19965622 DOI: 10.1182/Blood-2009-03-212274 |
0.465 |
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| 2010 |
D'Amico G, Korhonen EA, Waltari M, Saharinen P, Laakkonen P, Alitalo K. Loss of endothelial tie1 receptor impairs lymphatic vessel development-brief report Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 207-209. PMID 19910638 DOI: 10.1161/Atvbaha.109.196618 |
0.39 |
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| 2009 |
Hogan BM, Herpers R, Witte M, Heloterä H, Alitalo K, Duckers HJ, Schulte-Merker S. Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries Development. 136: 4001-4009. PMID 19906867 DOI: 10.1242/Dev.039990 |
0.322 |
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| 2009 |
Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2670-9. PMID 19705443 DOI: 10.1002/Dvdy.22078 |
0.357 |
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| 2009 |
Holopainen T, Huang H, Chen C, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K, He Y. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Research. 69: 4656-64. PMID 19487284 DOI: 10.1158/0008-5472.Can-08-4654 |
0.369 |
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| 2009 |
Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle Circulation Research. 104: 1302-1312. PMID 19443835 DOI: 10.1161/Circresaha.109.197830 |
0.466 |
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| 2009 |
MacHnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, MacHura K, Park JK, Beck FX, Müller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, Van Rooijen N, ... ... Alitalo K, et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism Nature Medicine. 15: 545-552. PMID 19412173 DOI: 10.1038/Nm.1960 |
0.472 |
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| 2009 |
Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. The Journal of Cell Biology. 185: 439-57. PMID 19398761 DOI: 10.1083/Jcb.200901104 |
0.375 |
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| 2009 |
Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Jung EB, Seung HH, Alitalo K, Gou YK. Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution Blood. 113: 5650-5659. PMID 19346498 DOI: 10.1182/Blood-2008-09-176776 |
0.419 |
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| 2009 |
Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nature Reviews. Molecular Cell Biology. 10: 165-77. PMID 19234476 DOI: 10.1038/Nrm2639 |
0.463 |
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| 2009 |
Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis Current Opinion in Cell Biology. 21: 154-165. PMID 19230644 DOI: 10.1016/J.Ceb.2008.12.012 |
0.481 |
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| 2009 |
Lähteenvuo JE, Lähteenvuo MT, Kivelä A, Rosenlew C, Falkevall A, Klar J, Heikura T, Rissanen TT, Vähäkangas E, Korpisalo P, Enholm B, Carmeliet P, Alitalo K, Eriksson U, Ylä-Herttuala S. Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms Circulation. 119: 845-856. PMID 19188502 DOI: 10.1161/Circulationaha.108.816454 |
0.437 |
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| 2009 |
Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice Molecular Therapy. 17: 278-284. PMID 19050699 DOI: 10.1038/Mt.2008.258 |
0.321 |
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| 2008 |
Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy Circulation Research. 103: 1359-1362. PMID 18988895 DOI: 10.1161/Circresaha.108.186577 |
0.321 |
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| 2008 |
Lohela M, Heloterä H, Haiko P, Dumont DJ, Alitalo K. Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues American Journal of Pathology. 173: 1891-1901. PMID 18988807 DOI: 10.2353/Ajpath.2008.080378 |
0.479 |
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| 2008 |
Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S. Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels Circulation Research. 103: 1092-1099. PMID 18832750 DOI: 10.1161/Circresaha.108.182287 |
0.439 |
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| 2008 |
Burton JB, Priceman SJ, Sung JL, Brakenhielm E, An DS, Pytowski B, Alitalo K, Wu L. Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Research. 68: 7828-37. PMID 18829538 DOI: 10.1158/0008-5472.Can-08-1488 |
0.352 |
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| 2008 |
Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, ... ... Alitalo K, et al. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy Circulation Research. 103: 1018-1026. PMID 18757827 DOI: 10.1161/Circresaha.108.178459 |
0.365 |
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| 2008 |
Kirjavainen A, Sulg M, Heyd F, Alitalo K, Ylä-Herttuala S, Möröy T, Petrova TV, Pirvola U. Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia Developmental Biology. 322: 33-45. PMID 18652815 DOI: 10.1016/J.Ydbio.2008.07.004 |
0.333 |
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| 2008 |
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, ... ... Alitalo K, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation Nature. 454: 656-660. PMID 18594512 DOI: 10.1038/Nature07083 |
0.481 |
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| 2008 |
Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis Cancer Research. 68: 4754-4762. PMID 18559522 DOI: 10.1158/0008-5472.Can-07-5809 |
0.502 |
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| 2008 |
Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos Molecular and Cellular Biology. 28: 4843-4850. PMID 18519586 DOI: 10.1128/Mcb.02214-07 |
0.475 |
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| 2008 |
Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, ... ... Alitalo K, et al. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1614-20. PMID 18511699 DOI: 10.1161/Atvbaha.107.158725 |
0.412 |
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| 2008 |
Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, ... ... Alitalo K, et al. Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype Cancer Cell. 13: 407-419. PMID 18455124 DOI: 10.1016/J.Ccr.2008.02.020 |
0.328 |
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| 2008 |
Purhonen S, Palm J, Rossi D, Kaskenpää N, Rajantie I, Ylä-Herttuala S, Alitalo K, Weissman IL, Salven P. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 6620-6625. PMID 18443294 DOI: 10.1073/Pnas.0710516105 |
0.486 |
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| 2008 |
Bruyère F, Melen-Lamalle L, Blacher S, Roland G, Thiry M, Moons L, Frankenne F, Carmeliet P, Alitalo K, Libert C, Sleeman JP, Foidart JM, Noël A. Modeling lymphangiogenesis in a three-dimensional culture system Nature Methods. 5: 431-437. PMID 18425139 DOI: 10.1038/Nmeth.1205 |
0.375 |
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| 2008 |
Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A, Vestweber D, Deutsch U, Koh GY, Olsen BR, Alitalo K. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts Nature Cell Biology. 10: 527-537. PMID 18425119 DOI: 10.1038/Ncb1715 |
0.441 |
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| 2008 |
Jeon BH, Jang C, Han J, Kataru RP, Piao L, Jung K, Hye JC, Schwendener RA, Kyu YJ, Kim KS, Alitalo K, Gou YK. Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer Cancer Research. 68: 1100-1109. PMID 18281485 DOI: 10.1158/0008-5472.Can-07-2572 |
0.487 |
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| 2008 |
Benest AV, Harper SJ, Herttuala SY, Alitalo K, Bates DO. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis Cardiovascular Research. 78: 315-323. PMID 18065770 DOI: 10.1093/Cvr/Cvm094 |
0.474 |
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| 2008 |
Karpanen T, Alitalo K. Molecular biology and pathology of lymphangiogenesis Annual Review of Pathology: Mechanisms of Disease. 3: 367-397. PMID 18039141 DOI: 10.1146/Annurev.Pathmechdis.3.121806.151515 |
0.409 |
|
| 2008 |
Karpanen T, Alitalo K. VEGF-D: A modifier of embryonic lymphangiogenesis Blood. 112: 1547-1548. DOI: 10.1182/Blood-2008-06-159343 |
0.453 |
|
| 2008 |
Keränen MAI, Nykänen AI, Krebs R, Sandelin H, Tuuminen R, Alitalo K, Pajusola K, Ylä-Herttuala S, Koskinen PK, Lemström KB. 417: Constitutively Expressed Hypoxia-Inducible Factor-1α Prevents the Development of Cardiac Allograft Vasculopathy in the Rat Journal of Heart and Lung Transplantation. 27. DOI: 10.1016/J.Healun.2007.11.429 |
0.333 |
|
| 2008 |
Krebs R, Tikkanen J, Nykänen A, Alitalo K, Ylä-Herttuala S, Koskinen P, Lemström K. 29: Role of Vascular Endothelial Growth Factor-C in Experimental Obliterative Airway Disease The Journal of Heart and Lung Transplantation. 27: S70. DOI: 10.1016/J.Healun.2007.11.033 |
0.437 |
|
| 2007 |
Mäkinen T, Alitalo K. Lymphangiogenesis in development and disease Novartis Foundation Symposium. 283: 87-98. PMID 18300416 DOI: 10.1002/9780470319413.Ch8 |
0.437 |
|
| 2007 |
Brideau G, Mäkinen MJ, Elamaa H, Tu H, Nilsson G, Alitalo K, Pihlajaniemi T, Heljasvaara R. Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice Cancer Research. 67: 11528-11535. PMID 18089781 DOI: 10.1158/0008-5472.Can-07-1458 |
0.402 |
|
| 2007 |
Ylä-Herttuala S, Alitalo K. On the relationship of LDL and VEGFR1: Not just a family affair Embo Reports. 8: 1127-1128. PMID 18059310 DOI: 10.1038/Sj.Embor.7401124 |
0.412 |
|
| 2007 |
Tammela T, Saaristo A, Holopainen T, Lyytikkä J, Kotronen A, Pitkonen M, Abo-Ramadan U, Ylä-Herttuala S, Petrova TV, Alitalo K. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation Nature Medicine. 13: 1458-1466. PMID 18059280 DOI: 10.1038/Nm1689 |
0.38 |
|
| 2007 |
Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM. Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis Plos Pathogens. 3: 1348-1360. PMID 17907806 DOI: 10.1371/Journal.Ppat.0030140 |
0.325 |
|
| 2007 |
Heloterä H, Alitalo K. The VEGF Family, the Inside Story Cell. 130: 591-592. PMID 17719536 DOI: 10.1016/J.Cell.2007.08.012 |
0.458 |
|
| 2007 |
Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. Modulating metastasis by a lymphangiogenic switch in prostate cancer. International Journal of Cancer. Journal International Du Cancer. 121: 2153-61. PMID 17583576 DOI: 10.1002/Ijc.22900 |
0.359 |
|
| 2007 |
Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Ylä-Herttuala S, Shibuya M, Alitalo K. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting Journal of Experimental Medicine. 204: 1431-1440. PMID 17535974 DOI: 10.1084/Jem.20062642 |
0.491 |
|
| 2007 |
Stacker SA, Farnsworth RH, Karnezis T, Shayan R, Smith DP, Paavonen K, Davydova N, Caesar C, Inder R, Baldwin ME, McColl BK, Roufail S, Williams RA, Hughes RA, Alitalo K, et al. Molecular pathways for lymphangiogenesis and their role in human disease. Novartis Foundation Symposium. 281: 38-43; discussion 44. PMID 17534064 DOI: 10.1002/9780470062128.Ch4 |
0.46 |
|
| 2007 |
Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis Nature Reviews Molecular Cell Biology. 8: 464-478. PMID 17522591 DOI: 10.1038/Nrm2183 |
0.43 |
|
| 2007 |
Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J, Yla-Herttuala S, Alitalo K. Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein Circulation Research. 100: 1460-1467. PMID 17478734 DOI: 10.1161/01.Res.0000269042.58594.F6 |
0.482 |
|
| 2007 |
Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K. Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins Circulation Research. 100: 1468-1475. PMID 17478733 DOI: 10.1161/01.Res.0000269043.51272.6D |
0.47 |
|
| 2007 |
Kopfstein L, Veikkola T, Djonov VG, Baeriswyl V, Schomber T, Strittmatter K, Stacker SA, Achen MG, Alitalo K, Christofori G. Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis American Journal of Pathology. 170: 1348-1361. PMID 17392173 DOI: 10.2353/Ajpath.2007.060835 |
0.451 |
|
| 2007 |
Raisky O, Nykänen AI, Krebs R, Hollmén M, Keränen MA, Tikkanen JM, Sihvola R, Alhonen L, Salven P, Wu Y, Hicklin DJ, Alitalo K, Koskinen PK, Lemström KB. VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 819-25. PMID 17290032 DOI: 10.1161/01.Atv.0000260001.55955.6C |
0.4 |
|
| 2007 |
McColl BK, Paavonen K, Karnezis T, Harris NC, Davydova N, Rothacker J, Nice EC, Harder KW, Roufail S, Hibbs ML, Rogers PAW, Alitalo K, Stacker SA, Achen MG. Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2 Faseb Journal. 21: 1088-1098. PMID 17242158 DOI: 10.1096/Fj.06-7060Com |
0.442 |
|
| 2007 |
Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte L, Alitalo K. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. Cancer Research. 67: 593-9. PMID 17234768 DOI: 10.1158/0008-5472.Can-06-3567 |
0.435 |
|
| 2007 |
Wick N, Saharinen P, Saharinen J, Gurnhofer E, Steiner CW, Raab I, Stokic D, Giovanoli P, Buchsbaum S, Burchard A, Thurner S, Alitalo K, Kerjaschki D. Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro Physiological Genomics. 28: 179-192. PMID 17234577 DOI: 10.1152/Physiolgenomics.00037.2006 |
0.465 |
|
| 2007 |
Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood. 109: 1010-7. PMID 17032920 DOI: 10.1182/Blood-2006-05-021758 |
0.351 |
|
| 2007 |
Tuuminen R, Keränen M, Nykänen A, Krebs R, Alitalo K, Koskinen P, Lemström K. PO9-252 PERSISTENT PDGF -A, -C, -D TRANSGENE EXPRESSION ACCELERATES DEVELOPMENT OF CARDIAC ALLOGRAFT VASCULOPATHY AND FIBROSIS BUT NOT -B INDUCES MYOCARDIAL ANGIOGENESIS Atherosclerosis Supplements. 8: 79. DOI: 10.1016/S1567-5688(07)71262-X |
0.326 |
|
| 2007 |
Leppanen P, Koota S, Kholova I, Koponen J, Fieber C, Eriksson U, Alitalo K, Ylä-Herttuala S. PO6-160 GENE TRANSFERS OF VEGF-GENE FAMILY HAVE NO EFFECT ON ATHEROSCLEROSIS IN LDLR/APOB48-DEFICIENT MICE Atherosclerosis Supplements. 8: 57. DOI: 10.1016/S1567-5688(07)71170-4 |
0.315 |
|
| 2007 |
Tuuminen R, Keranen MAI, Nykanen AI, Krebs R, Alitalo K, Koskinen PK, Lemstrom KB. 444: Persistent PDGF-A, -C, -D transgene expression enhances cardiac allograft vasculopathy and fibrosis, but PDGF-B induces myocardial angiogenesis Journal of Heart and Lung Transplantation. 26. DOI: 10.1016/J.Healun.2006.11.466 |
0.326 |
|
| 2006 |
Leppänen P, Kholová I, Mähönen AJ, Airenne K, Koota S, Mansukoski H, Närväinen J, Wirzenius M, Alhonen L, Jänne J, Alitalo K, Ylä-Herttuala S. Short and long-term effects of hVEGF-A165 in cre-activated transgenic mice Plos One. 1. PMID 17183639 DOI: 10.1371/Journal.Pone.0000013 |
0.307 |
|
| 2006 |
Saaristo A, Tammela T, Farkkilā A, Kärkkäinen M, Suominen E, Yla-Herttuala S, Alitalo K. Vascular endothelial growth factor-C accelerates diabetic wound healing. The American Journal of Pathology. 169: 1080-7. PMID 16936280 DOI: 10.2353/Ajpath.2006.051251 |
0.395 |
|
| 2006 |
He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, ... Alitalo K, et al. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis Journal of Clinical Investigation. 116: 2344-2355. PMID 16932810 DOI: 10.1172/Jci28123 |
0.369 |
|
| 2006 |
Karpanen T, Wirzenius M, Mäkinen T, Veikkola T, Haisma HJ, Achen MG, Stacker SA, Pytowski B, Ylä-Herttuala S, Alitalo K. Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. The American Journal of Pathology. 169: 708-18. PMID 16877368 DOI: 10.2353/Ajpath.2006.051200 |
0.475 |
|
| 2006 |
Kärpänen T, Heckman CA, Keskitalo S, Jeltsch M, Ollila H, Neufeld G, Tamagnone L, Alitalo K. Functional interaction of VEGF-C and VEGF-D with neuropilin receptors Faseb Journal. 20: 1462-1472. PMID 16816121 DOI: 10.1096/Fj.05-5646Com |
0.431 |
|
| 2006 |
Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M. Chimeric VEGF-ENZ7/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2019-2026. PMID 16794222 DOI: 10.1161/01.Atv.0000233336.53574.A1 |
0.466 |
|
| 2006 |
Schaffhauser B, Veikkola T, Strittmatter K, Antoniadis H, Alitalo K, Christofori G. Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice Journal of Leukocyte Biology. 80: 669-676. PMID 16793908 DOI: 10.1189/Jlb.1105644 |
0.337 |
|
| 2006 |
Janér J, Lassus P, Haglund C, Paavonen K, Alitalo K, Andersson S. Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants. American Journal of Respiratory and Critical Care Medicine. 174: 326-30. PMID 16690974 DOI: 10.1164/Rccm.200508-1291Oc |
0.389 |
|
| 2006 |
Nykänen AI, Pajusola K, Krebs R, Keränen MA, Raisky O, Koskinen PK, Alitalo K, Lemström KB. Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy. Circulation Research. 98: 1373-80. PMID 16690881 DOI: 10.1161/01.Res.0000225987.52765.13 |
0.358 |
|
| 2006 |
Brindle NP, Saharinen P, Alitalo K. Signaling and functions of angiopoietin-1 in vascular protection. Circulation Research. 98: 1014-23. PMID 16645151 DOI: 10.1161/01.Res.0000218275.54089.12 |
0.401 |
|
| 2006 |
Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K. Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns. The Journal of Biological Chemistry. 281: 12187-95. PMID 16505489 DOI: 10.1074/Jbc.M511593200 |
0.46 |
|
| 2006 |
Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, ... Alitalo K, et al. Large-scale identification of genes implicated in kidney glomerulus development and function. The Embo Journal. 25: 1160-74. PMID 16498405 DOI: 10.1038/Sj.Emboj.7601014 |
0.339 |
|
| 2006 |
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, et al. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neuroscience. 9: 340-8. PMID 16462734 DOI: 10.1038/Nn1646 |
0.483 |
|
| 2006 |
Roy H, Bhardwaj S, Babu M, Jauhiainen S, Herzig KH, Bellu AR, Haisma HJ, Carmeliet P, Alitalo K, Ylä-Herttuala S. Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A. Human Gene Therapy. 16: 1422-8. PMID 16390273 DOI: 10.1089/Hum.2005.16.1422 |
0.483 |
|
| 2006 |
Leppänen P, Koota S, Kholová I, Koponen J, Fieber C, Eriksson U, Alitalo K, Ylä-Herttuala S. Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice. Circulation. 112: 1347-52. PMID 16129816 DOI: 10.1161/Circulationaha.105.534107 |
0.465 |
|
| 2006 |
Tammela T, Alitalo K. Yet another function for hepatocyte growth factor Blood. 107: 3424-3425. DOI: 10.1182/Blood-2006-02-001883 |
0.378 |
|
| 2006 |
Saaristo A, Tammela T, Tukiainen E, Alitalo K. Vascular Endothelial Growth Factor C (VEGF-C) Gene Therapy Attenuates Postoperative Lymphedema by Regenerating Collective Lymphatic Vessels Journal of Reconstructive Microsurgery. 22. DOI: 10.1055/S-2006-947905 |
0.458 |
|
| 2005 |
Pätilä T, Ikonen T, Rutanen J, Ahonen A, Lommi J, Lappalainen K, Krogerus L, Ihlberg L, Partanen TA, Lähteenoja L, Virtanen K, Alitalo K, Ylä-Herttuala S, Harjula A. Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 25: 206-13. PMID 16446222 DOI: 10.1016/J.Healun.2005.08.013 |
0.482 |
|
| 2005 |
Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature. 438: 946-53. PMID 16355212 DOI: 10.1111/J.1600-0625.2007.00607_3.X |
0.321 |
|
| 2005 |
Oliver G, Alitalo K. The lymphatic vasculature: recent progress and paradigms. Annual Review of Cell and Developmental Biology. 21: 457-83. PMID 16212503 DOI: 10.1146/Annurev.Cellbio.21.012704.132338 |
0.344 |
|
| 2005 |
Ozerdem U, Alitalo K, Salven P, Li A. Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis. Investigative Ophthalmology & Visual Science. 46: 3502-6. PMID 16186326 DOI: 10.1167/Iovs.05-0309 |
0.303 |
|
| 2005 |
Wickström SA, Alitalo K, Keski-Oja J. Endostatin signaling and regulation of endothelial cell-matrix interactions. Advances in Cancer Research. 94: 197-229. PMID 16096002 DOI: 10.1016/S0065-230X(05)94005-0 |
0.473 |
|
| 2005 |
Lin J, Lalani AS, Harding TC, Gonzalez M, Wu WW, Luan B, Tu GH, Koprivnikar K, VanRoey MJ, He Y, Alitalo K, Jooss K. Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Research. 65: 6901-9. PMID 16061674 DOI: 10.1158/0008-5472.Can-05-0408 |
0.388 |
|
| 2005 |
Tammela T, Petrova TV, Alitalo K. Molecular lymphangiogenesis: new players. Trends in Cell Biology. 15: 434-41. PMID 16005628 DOI: 10.1016/J.Tcb.2005.06.004 |
0.452 |
|
| 2005 |
Pajusola K, Künnapuu J, Vuorikoski S, Soronen J, André H, Pereira T, Korpisalo P, Ylä-Herttuala S, Poellinger L, Alitalo K. Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1365-7. PMID 15958522 DOI: 10.1096/Fj.05-3720Fje |
0.4 |
|
| 2005 |
He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Research. 65: 4739-46. PMID 15930292 DOI: 10.1158/0008-5472.Can-04-4576 |
0.437 |
|
| 2005 |
Eichmann A, Makinen T, Alitalo K. Neural guidance molecules regulate vascular remodeling and vessel navigation. Genes & Development. 19: 1013-21. PMID 15879551 DOI: 10.1101/Gad.1305405 |
0.38 |
|
| 2005 |
Saharinen P, Kerkelä K, Ekman N, Marron M, Brindle N, Lee GM, Augustin H, Koh GY, Alitalo K. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2 Journal of Cell Biology. 169: 239-243. PMID 15851516 DOI: 10.1083/Jcb.200411105 |
0.34 |
|
| 2005 |
Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmén C, Oike Y, Pajusola K, Thurston G, Suda T, Yla-Herttuala S, Alitalo K. Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood. 105: 4642-8. PMID 15746084 DOI: 10.1182/Blood-2004-08-3327 |
0.478 |
|
| 2005 |
Kempf VAJ, Lebiedziejewski M, Alitalo K, Wälzlein JH, Ehehalt U, Fiebig J, Huber S, Schütt B, Sander CA, Müller S, Grassl G, Yazdi AS, Brehm B, Autenrieth IB. Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: Evidence for a role of hypoxia-inducible factor-1 in bacterial infections Circulation. 111: 1054-1062. PMID 15723970 DOI: 10.1161/01.Cir.0000155608.07691.B7 |
0.395 |
|
| 2005 |
Morisada T, Oike Y, Yamada Y, Urano T, Akao M, Kubota Y, Maekawa H, Kimura Y, Ohmura M, Miyamoto T, Nozawa S, Koh GY, Alitalo K, Suda T. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood. 105: 4649-56. PMID 15705793 DOI: 10.1182/Blood-2004-08-3382 |
0.449 |
|
| 2005 |
Mäkinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature Genes and Development. 19: 397-410. PMID 15687262 DOI: 10.1101/Gad.330105 |
0.354 |
|
| 2005 |
Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald DM. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. The Journal of Clinical Investigation. 115: 247-57. PMID 15668734 DOI: 10.1172/Jci22037 |
0.419 |
|
| 2005 |
Tammela T, Enholm B, Alitalo K, Paavonen K. The biology of vascular endothelial growth factors. Cardiovascular Research. 65: 550-63. PMID 15664381 DOI: 10.1016/J.Cardiores.2004.12.002 |
0.476 |
|
| 2005 |
Bhardwaj S, Roy H, Kärpänen T, He Y, Hi Y, Jauhiainen S, Hedman M, Alitalo K, Ylä-Herttuala S. Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries. Gene Therapy. 12: 388-94. PMID 15647771 DOI: 10.1038/Sj.Gt.3302426 |
0.427 |
|
| 2005 |
Crnic I, Strittmatter K, Cavallaro U, Kopfstein L, Jussila L, Alitalo K, Christofori G. Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Cancer Research. 64: 8630-8. PMID 15574770 DOI: 10.1158/0008-5472.Can-04-2523 |
0.406 |
|
| 2005 |
Nilsson I, Rolny C, Wu Y, Pytowski B, Hicklin D, Alitalo K, Claesson-Welsh L, Wennström S. Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1507-15. PMID 15466359 DOI: 10.1096/Fj.03-1276Com |
0.473 |
|
| 2005 |
Enholm B, Jussila L, Karkkainen M, Alitalo K. Vascular endothelial growth factor-C: a growth factor for lymphatic and blood vascular endothelial cells. Trends in Cardiovascular Medicine. 8: 292-7. PMID 14987553 DOI: 10.1016/S1050-1738(98)00026-7 |
0.511 |
|
| 2004 |
Saaristo A, Tammela T, Timonen J, Yla-Herttuala S, Tukiainen E, Asko-Seljavaara S, Alitalo K. Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds The Faseb Journal. 18: 1707-1709. PMID 15361472 DOI: 10.1096/Fj.04-1592Fje |
0.459 |
|
| 2004 |
Petrova TV, Karpanen T, Norrmén C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Ylä-Herttuala S, Miura N, Alitalo K. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nature Medicine. 10: 974-81. PMID 15322537 DOI: 10.1038/Nm1094 |
0.436 |
|
| 2004 |
Uutela M, Wirzenius M, Paavonen K, Rajantie I, He Y, Karpanen T, Lohela M, Wiig H, Salven P, Pajusola K, Eriksson U, Alitalo K. PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Blood. 104: 3198-204. PMID 15271796 DOI: 10.1182/Blood-2004-04-1485 |
0.399 |
|
| 2004 |
Paavonen K, Ekman N, Wirzenius M, Rajantie I, Poutanen M, Alitalo K. Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Molecular Biology of the Cell. 15: 4226-33. PMID 15229285 DOI: 10.1091/Mbc.E04-03-0241 |
0.343 |
|
| 2004 |
Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Mäkinen T, Elliman S, Flanagan AM, Alitalo K, Boshoff C. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nature Genetics. 36: 687-93. PMID 15220918 DOI: 10.1038/Ng1384 |
0.426 |
|
| 2004 |
Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends in Immunology. 25: 387-95. PMID 15207507 DOI: 10.1016/J.It.2004.05.003 |
0.489 |
|
| 2004 |
Bando H, Brokelmann M, Toi M, Alitalo K, Sleeman JP, Sipos B, Gröne HJ, Weich HA. Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues International Journal of Cancer. 111: 184-191. PMID 15197769 DOI: 10.1002/Ijc.20211 |
0.485 |
|
| 2004 |
Rajantie I, Ilmonen M, Alminaite A, Ozerdem U, Alitalo K, Salven P. Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood. 104: 2084-6. PMID 15191949 DOI: 10.1182/Blood-2004-01-0336 |
0.472 |
|
| 2004 |
Stolen CM, Yegutkin GG, Kurkijärvi R, Bono P, Alitalo K, Jalkanen S. Origins of serum semicarbazide-sensitive amine oxidase. Circulation Research. 95: 50-7. PMID 15178639 DOI: 10.1161/01.Res.0000134630.68877.2F |
0.388 |
|
| 2004 |
He Y, Rajantie I, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K. Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Research. 64: 3737-40. PMID 15172976 DOI: 10.1158/0008-5472.Can-04-0088 |
0.47 |
|
| 2004 |
Gruchała M, Bhardwaj S, Pajusola K, Roy H, Rissanen TT, Kokina I, Kholová I, Markkanen JE, Rutanen J, Heikura T, Alitalo K, Büeler H, Ylä-Herttuala S. Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors. Journal of Gene Medicine. 6: 545-554. PMID 15133765 DOI: 10.1002/Jgm.535 |
0.391 |
|
| 2004 |
He Y, Karpanen T, Alitalo K. Role of lymphangiogenic factors in tumor metastasis. Biochimica Et Biophysica Acta. 1654: 3-12. PMID 14984763 DOI: 10.1016/J.Bbcan.2003.07.003 |
0.431 |
|
| 2004 |
Weich HA, Bando H, Brokelmann M, Baumann P, Toi M, Barleon B, Alitalo K, Sipos B, Sleeman J. Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA Journal of Immunological Methods. 285: 145-155. PMID 14980429 DOI: 10.1016/J.Jim.2003.10.015 |
0.459 |
|
| 2004 |
Wickström SA, Alitalo K, Keski-Oja J. An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. The Journal of Biological Chemistry. 279: 20178-85. PMID 14973128 DOI: 10.1074/Jbc.M312921200 |
0.362 |
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| 2004 |
Leppänen O, Rutanen J, Hiltunen MO, Rissanen TT, Turunen MP, Sjöblom T, Brüggen J, Bäckström G, Carlsson M, Buchdunger E, Bergqvist D, Alitalo K, Heldin C, Östman A, Ylä-Herttuala S. Oral Imatinib Mesylate (STI571/Gleevec) Improves the Efficacy of Local Intravascular Vascular Endothelial Growth Factor-C Gene Transfer in Reducing Neointimal Growth in Hypercholesterolemic Rabbits Circulation. 109: 1140-1146. PMID 14769706 DOI: 10.1161/01.Cir.0000117234.08626.7C |
0.458 |
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| 2004 |
Cao R, Eriksson A, Kubo H, Alitalo K, Cao Y, Thyberg J. Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability. Circulation Research. 94: 664-70. PMID 14739162 DOI: 10.1161/01.Res.0000118600.91698.Bb |
0.465 |
|
| 2004 |
Ober EA, Olofsson B, Mäkinen T, Jin SW, Shoji W, Koh GY, Alitalo K, Stainier DYR. Vegfc is required for vascular development and endoderm morphogenesis in zebrafish Embo Reports. 5: 78-84. PMID 14710191 DOI: 10.1038/Sj.Embor.7400047 |
0.442 |
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| 2004 |
Karkkainen MJ, Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, Jeltsch M, Jackson DG, Talikka M, Rauvala H, Betsholtz C, Alitalo K. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nature Immunology. 5: 74-80. PMID 14634646 DOI: 10.1038/Ni1013 |
0.485 |
|
| 2004 |
Bhardwaj S, Roy H, Gruchala M, Viita H, Kholova I, Kokina I, Achen MG, Stacker SA, Hedman M, Alitalo K, Ylä-Herttuala S. Angiogenic responses of vascular endothelial growth factors in periadventitial tissue. Human Gene Therapy. 14: 1451-62. PMID 14577925 DOI: 10.1089/104303403769211664 |
0.472 |
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| 2004 |
Rutanen J, Leppänen P, Tuomisto TT, Rissanen TT, Hiltunen MO, Vajanto I, Niemi M, Häkkinen T, Karkola K, Stacker SA, Achen MG, Alitalo K, Ylä-Herttuala S. Vascular endothelial growth factor-D expression in human atherosclerotic lesions. Cardiovascular Research. 59: 971-9. PMID 14553837 DOI: 10.1016/S0008-6363(03)00518-2 |
0.441 |
|
| 2004 |
Lohela M, Saaristo A, Veikkola T, Alitalo K. Lymphangiogenic growth factors, receptors and therapies. Thrombosis and Haemostasis. 90: 167-84. PMID 12888864 DOI: 10.1160/Th03-04-0200 |
0.522 |
|
| 2004 |
Wickström SA, Keski-Oja J, Alitalo K. Matrix reloaded to circulation hits the tumor target. Cancer Cell. 3: 513-4. PMID 12842077 DOI: 10.1016/S1535-6108(03)00143-0 |
0.374 |
|
| 2004 |
Lin J, Lalani AS, Harding T, Wu W, Luan B, Yendluri S, VanRoey MJ, He Y, Alitalo K, Jooss K. 974. Adeno-Associated Viral (AAV)-Mediated Gene Transfer of Soluble Vascular Endothelial Growth Factor Receptor 3 (sVEGFR3) Inhibits Development of Lymph Node Metastases Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.917 |
0.382 |
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| 2004 |
Bhardwaj S, Roy H, Alitalo K, Yla-Herttuala S. 389. Placental Growth Factor (PIGF) Gene Transfer to the Periadventitial Tissue Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.329 |
0.471 |
|
| 2004 |
McColl BK, Baldwin ME, Roufail S, Freeman C, Alitalo K, Stacker SA, Achen MG. Plasmin activates VEGF-C and VEGF-D International Congress Series. 1262: 79-82. DOI: 10.1016/j.ics.2003.11.032 |
0.305 |
|
| 2004 |
McColl B, Baldwin M, Roufail S, Alitalo K, Stacker S, Achen M. Proteolytic Activation Of Vegf-C And Vegf-D Cardiovascular Pathology. 13: 20. DOI: 10.1016/J.Carpath.2004.03.055 |
0.419 |
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| 2003 |
Porat RM, Grunewald M, Globerman A, Itin A, Barshtein G, Alhonen L, Alitalo K, Keshet E. Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies. Circulation Research. 94: 394-401. PMID 14670840 DOI: 10.1161/01.Res.0000111803.92923.D6 |
0.397 |
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| 2003 |
Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Petrova T, Jeltsch M, Augustin HG, Alitalo K. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 2006-13. PMID 14597670 DOI: 10.1096/Fj.03-0179Com |
0.494 |
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| 2003 |
Zhang R, Xu Y, Ekman N, Wu Z, Wu J, Alitalo K, Min W. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. The Journal of Biological Chemistry. 278: 51267-76. PMID 14532277 DOI: 10.1074/Jbc.M310678200 |
0.417 |
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| 2003 |
McColl BK, Baldwin ME, Roufail S, Freeman C, Moritz RL, Simpson PJ, Alitalo K, Stacker SA, Achen MG. Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D Journal of Experimental Medicine. 198: 863-868. PMID 12963694 DOI: 10.1084/Jem.20030361 |
0.483 |
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| 2003 |
Iivanainen E, Nelimarkka L, Elenius V, Heikkinen SM, Junttila TT, Sihombing L, Sundvall M, Maatta JA, Laine VJ, Yla-Herttuala S, Higashiyama S, Alitalo K, Elenius K. Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1609-21. PMID 12958167 DOI: 10.1096/Fj.02-0939Com |
0.484 |
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| 2003 |
Jeltsch M, Tammela T, Alitalo K, Wilting J. Genesis and pathogenesis of lymphatic vessels. Cell and Tissue Research. 314: 69-84. PMID 12942362 DOI: 10.1007/S00441-003-0777-2 |
0.451 |
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| 2003 |
Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. The Journal of Biological Chemistry. 278: 40973-9. PMID 12881528 DOI: 10.1074/Jbc.M304499200 |
0.479 |
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| 2003 |
Hu B, Guo P, Fang Q, Tao HQ, Wang D, Nagane M, Huang HJ, Gunji Y, Nishikawa R, Alitalo K, Cavenee WK, Cheng SY. Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 8904-9. PMID 12861074 DOI: 10.1073/Pnas.1533394100 |
0.322 |
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| 2003 |
Wickström SA, Alitalo K, Keski-Oja J. Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity. The Journal of Biological Chemistry. 278: 37895-901. PMID 12851410 DOI: 10.1074/Jbc.M303569200 |
0.374 |
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| 2003 |
Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia Journal of Cell Biology. 161: 1163-1177. PMID 12810700 DOI: 10.1083/Jcb.200302047 |
0.483 |
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| 2003 |
Ylä-Herttuala S, Alitalo K. Gene transfer as a tool to induce therapeutic vascular growth. Nature Medicine. 9: 694-701. PMID 12778168 DOI: 10.1038/Nm0603-694 |
0.394 |
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| 2003 |
Saharinen P, Alitalo K. Double target for tumor mass destruction. The Journal of Clinical Investigation. 111: 1277-80. PMID 12727916 DOI: 10.1172/Jci200318539 |
0.426 |
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| 2003 |
Rissanen TT, Markkanen JE, Gruchala M, Heikura T, Puranen A, Kettunen MI, Kholová I, Kauppinen RA, Achen MG, Stacker SA, Alitalo K, Ylä-Herttuala S. VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circulation Research. 92: 1098-106. PMID 12714562 DOI: 10.1161/01.Res.0000073584.46059.E3 |
0.47 |
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| 2003 |
Tille JC, Wang X, Lipson KE, McMahon G, Ferrara N, Zhu Z, Hicklin DJ, Sleeman JP, Eriksson U, Alitalo K, Pepper MS. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Experimental Cell Research. 285: 286-98. PMID 12706123 DOI: 10.1016/S0014-4827(03)00053-3 |
0.49 |
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| 2003 |
Nykänen AI, Krebs R, Saaristo A, Turunen P, Alitalo K, Ylä-Herttuala S, Koskinen PK, Lemström KB. Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis. Circulation. 107: 1308-14. PMID 12628953 DOI: 10.1161/01.Cir.0000054623.35669.3F |
0.425 |
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| 2003 |
Kubo H, Alitalo K. The bloody fate of endothelial stem cells. Genes & Development. 17: 322-9. PMID 12569121 DOI: 10.1101/Gad.1071203 |
0.361 |
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| 2003 |
Auvinen M, Järvinen K, Hotti A, Okkeri J, Laitinen J, Jänne OA, Coffino P, Bergman M, Andersson LC, Alitalo K, Hölttä E. Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc. The International Journal of Biochemistry & Cell Biology. 35: 496-521. PMID 12565711 DOI: 10.1016/S1357-2725(02)00305-9 |
0.356 |
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| 2003 |
Saaristo A, Karkkainen MJ, Alitalo K. Insights into the molecular pathogenesis and targeted treatment of lymphedema. Annals of the New York Academy of Sciences. 979: 94-110. PMID 12543720 DOI: 10.1111/J.1749-6632.2002.Tb04871.X |
0.484 |
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| 2003 |
Marchetti S, Gimond C, Iljin K, Bourcier C, Alitalo K, Pouysségur J, Pagès G. Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo. Journal of Cell Science. 115: 2075-85. PMID 11973349 DOI: 10.1242/jcs.115.10.2075 |
0.316 |
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| 2003 |
McColl B, Baldwin M, Roufail S, Freeman C, Moritz R, Simpson R, Alitalo K, Stacker S, Achen M. 2SY04-4 VEGF-D: A molecular regulator of lymphangiogenesis Atherosclerosis Supplements. 4: 90. DOI: 10.1016/S1567-5688(03)90391-6 |
0.358 |
|
| 2002 |
Shah RN, Ibbitt JC, Alitalo K, Hurst HC. FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha. Oncogene. 21: 8251-61. PMID 12447688 DOI: 10.1038/Sj.Onc.1206020 |
0.346 |
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| 2002 |
Iljin K, Petrova TV, Veikkola T, Kumar V, Poutanen M, Alitalo K. A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1764-74. PMID 12409319 DOI: 10.1096/Fj.01-1043Com |
0.437 |
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| 2002 |
Szuba A, Skobe M, Karkkainen MJ, Shin WS, Beynet DP, Rockson NB, Dakhil N, Spilman S, Goris ML, Strauss HW, Quertermous T, Alitalo K, Rockson SG. Therapeutic lymphangiogenesis with human recombinant VEGF-C. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1985-7. PMID 12397087 DOI: 10.1096/Fj.02-0401Fje |
0.448 |
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| 2002 |
Salven P, Mustjoki S, Alitalo R, Alitalo K, Rafii S. VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood. 101: 168-72. PMID 12393704 DOI: 10.1182/Blood-2002-03-0755 |
0.36 |
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| 2002 |
Yuan L, Moyon D, Pardanaud L, Bréant C, Karkkainen MJ, Alitalo K, Eichmann A. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development (Cambridge, England). 129: 4797-806. PMID 12361971 DOI: 10.1242/dev.129.20.4797 |
0.333 |
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| 2002 |
Veikkola T, Alitalo K. Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis. Developmental Cell. 3: 302-4. PMID 12361591 DOI: 10.1016/S1534-5807(02)00231-9 |
0.45 |
|
| 2002 |
Saaristo A, Veikkola T, Tammela T, Enholm B, Karkkainen MJ, Pajusola K, Bueler H, Ylä-Herttuala S, Alitalo K. Lymphangiogenic gene therapy with minimal blood vascular side effects. The Journal of Experimental Medicine. 196: 719-30. PMID 12235206 DOI: 10.1084/Jem.20020587 |
0.477 |
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| 2002 |
Schoppmann SF, Birner P, Stöckl J, Kalt R, Ullrich R, Caucig C, Kriehuber E, Nagy K, Alitalo K, Kerjaschki D. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. The American Journal of Pathology. 161: 947-56. PMID 12213723 DOI: 10.1016/S0002-9440(10)64255-1 |
0.491 |
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| 2002 |
Petrova TV, Mäkinen T, Mäkelä TP, Saarela J, Virtanen I, Ferrell RE, Finegold DN, Kerjaschki D, Ylä-Herttuala S, Alitalo K. Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. The Embo Journal. 21: 4593-9. PMID 12198161 DOI: 10.1093/Emboj/Cdf470 |
0.463 |
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| 2002 |
Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K. Lymphangiogenesis and cancer metastasis Nature Reviews Cancer. 2: 573-583. PMID 12154350 DOI: 10.1038/Nrc863 |
0.344 |
|
| 2002 |
Eriksson U, Alitalo K. VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies. Nature Medicine. 8: 775-7. PMID 12152025 DOI: 10.1038/Nm0802-775 |
0.45 |
|
| 2002 |
Achen MG, Williams RA, Baldwin ME, Lai P, Roufail S, Alitalo K, Stacker SA. The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer Growth Factors. 20: 99-107. PMID 12148568 DOI: 10.1080/08977190290031969 |
0.441 |
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| 2002 |
Jussila L, Alitalo K. Vascular growth factors and lymphangiogenesis. Physiological Reviews. 82: 673-700. PMID 12087132 DOI: 10.1152/Physrev.00005.2002 |
0.499 |
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| 2002 |
Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K, Turunen P, Jeltsch M, Karkkainen MJ, Kerjaschki D, Bueler H, Ylä-Herttuala S, Alitalo K. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1041-9. PMID 12087065 DOI: 10.1096/Fj.01-1042Com |
0.471 |
|
| 2002 |
Alitalo K, Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell. 1: 219-27. PMID 12086857 DOI: 10.1016/S1535-6108(02)00051-X |
0.467 |
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| 2002 |
Kubo H, Cao R, Brakenhielm E, Mäkinen T, Cao Y, Alitalo K. Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proceedings of the National Academy of Sciences of the United States of America. 99: 8868-73. PMID 12070340 DOI: 10.1073/Pnas.062040199 |
0.503 |
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| 2002 |
Wilting J, Papoutsi M, Christ B, Nicolaides KH, von Kaisenberg CS, Borges J, Stark GB, Alitalo K, Tomarev SI, Niemeyer C, Rössler J. The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1271-3. PMID 12060670 DOI: 10.1096/Fj.01-1010Fje |
0.375 |
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| 2002 |
He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. Journal of the National Cancer Institute. 94: 819-25. PMID 12048269 DOI: 10.1093/Jnci/94.11.819 |
0.44 |
|
| 2002 |
Lemström KB, Krebs R, Nykänen AI, Tikkanen JM, Sihvola RK, Aaltola EM, Häyry PJ, Wood J, Alitalo K, Ylä-Herttuala S, Koskinen PK. Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis Circulation. 105: 2524-2530. PMID 12034660 DOI: 10.1161/01.Cir.0000016821.76177.D2 |
0.39 |
|
| 2002 |
Karkkainen MJ, Alitalo K. Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis. Seminars in Cell & Developmental Biology. 13: 9-18. PMID 11969367 DOI: 10.1006/Scdb.2001.0286 |
0.486 |
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| 2002 |
Mattila MM, Ruohola JK, Karpanen T, Jackson DG, Alitalo K, Härkönen PL. VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. International Journal of Cancer. 98: 946-51. PMID 11948478 DOI: 10.1002/Ijc.10283 |
0.42 |
|
| 2002 |
Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. The American Journal of Pathology. 160: 1405-23. PMID 11943725 DOI: 10.1016/S0002-9440(10)62567-9 |
0.484 |
|
| 2002 |
Dias S, Choy M, Alitalo K, Rafii S. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood. 99: 2179-84. PMID 11877295 DOI: 10.1182/Blood.V99.6.2179 |
0.506 |
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| 2002 |
Witmer AN, Blaauwgeers HG, Weich HA, Alitalo K, Vrensen GF, Schlingemann RO. Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey. Investigative Ophthalmology & Visual Science. 43: 849-57. PMID 11867607 |
0.313 |
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| 2002 |
Paavonen K, Mandelin J, Partanen T, Jussila L, Li TF, Ristimaki A, Alitalo K, Konttinen YT. Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium. The Journal of Rheumatology. 29: 39-45. PMID 11824969 |
0.347 |
|
| 2002 |
Karkkainen MJ, Mäkinen T, Alitalo K. Lymphatic endothelium: a new frontier of metastasis research. Nature Cell Biology. 4: E2-5. PMID 11780131 DOI: 10.1038/Ncb0102-E2 |
0.484 |
|
| 2002 |
Heino TI, Kärpänen T, Wahlström G, Pulkkinen M, Eriksson U, Alitalo K, Roos C. The Drosophila VEGF receptor homolog is expressed in hemocytes. Mechanisms of Development. 109: 69-77. PMID 11677054 DOI: 10.1016/S0925-4773(01)00510-X |
0.459 |
|
| 2001 |
Koolwijk P, Peters E, Vecht Bvd, Hornig C, Weich HA, Alitalo K, Hicklin DJ, Wu Y, Witte L, Hinsbergh VWMv. Involvement Of Vegfr-2 (Kdr/Flk-1) But Not Vegfr-1 (Flt-1) In Vegf-A And Vegf-C-Induced Tube Formation By Human Microvascular Endothelial Cells In Fibrin Matrices In Vitro Angiogenesis. 4: 53-60. PMID 11824379 DOI: 10.1023/A:1016637700638 |
0.476 |
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| 2001 |
Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K. A model for gene therapy of human hereditary lymphedema. Proceedings of the National Academy of Sciences of the United States of America. 98: 12677-82. PMID 11592985 DOI: 10.1073/Pnas.221449198 |
0.44 |
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| 2001 |
Baldwin ME, Roufail S, Halford MM, Alitalo K, Stacker SA, Achen MG. Multiple Forms of Mouse Vascular Endothelial Growth Factor-D Are Generated by RNA Splicing and Proteolysis Journal of Biological Chemistry. 276: 44307-44314. PMID 11574540 DOI: 10.1074/Jbc.M106188200 |
0.449 |
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| 2001 |
Ayadi A, Zheng H, Sobieszczuk P, Buchwalter G, Moerman P, Alitalo K, Wasylyk B. Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1. The Embo Journal. 20: 5139-52. PMID 11566878 DOI: 10.1093/Emboj/20.18.5139 |
0.394 |
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| 2001 |
Karpanen T, Alitalo K. Lymphatic vessels as targets of tumor therapy? The Journal of Experimental Medicine. 194: F37-42. PMID 11561002 DOI: 10.1084/Jem.194.6.F37 |
0.345 |
|
| 2001 |
Kempf VA, Volkmann B, Schaller M, Sander CA, Alitalo K, Riess T, Autenrieth IB. Evidence of a leading role for VEGF in Bartonella henselae-induced endothelial cell proliferations. Cellular Microbiology. 3: 623-32. PMID 11553014 DOI: 10.1046/J.1462-5822.2001.00144.X |
0.473 |
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| 2001 |
Skobe M, Hamberg LM, Hawighorst T, Schirner M, Wolf GL, Alitalo K, Detmar M. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. The American Journal of Pathology. 159: 893-903. PMID 11549582 DOI: 10.1016/S0002-9440(10)61765-8 |
0.483 |
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| 2001 |
Mäkinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A, Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. The Embo Journal. 20: 4762-73. PMID 11532940 DOI: 10.1093/Emboj/20.17.4762 |
0.507 |
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| 2001 |
Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Mäkelä TP. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science (New York, N.Y.). 293: 1323-6. PMID 11509733 DOI: 10.1126/Science.1062074 |
0.47 |
|
| 2001 |
Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. The Journal of Cell Biology. 154: 345-54. PMID 11470823 DOI: 10.1083/Jcb.200102032 |
0.313 |
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| 2001 |
Aase K, Euler Gv, Li X, Pontén A, Thorén P, Cao R, Cao Y, Olofsson B, Gebre-Medhin S, Pekny M, Alitalo K, Betsholtz C, Eriksson U. Vascular Endothelial Growth Factor-B–Deficient Mice Display an Atrial Conduction Defect Circulation. 104: 358-364. PMID 11457758 DOI: 10.1161/01.Cir.104.3.358 |
0.441 |
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| 2001 |
Alitalo K. The fatal detachment. Nature Cell Biology. 3: E157-9. PMID 11433307 DOI: 10.1038/35083104 |
0.331 |
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| 2001 |
Karkkainen MJ, Jussila L, Ferrell RE, Finegold DN, Alitalo K. Molecular regulation of lymphangiogenesis and targets for tissue oedema. Trends in Molecular Medicine. 7: 18-22. PMID 11427983 DOI: 10.1016/S1471-4914(00)01864-5 |
0.466 |
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| 2001 |
Rajantie I, Ekman N, Iljin K, Arighi E, Gunji Y, Kaukonen J, Palotie A, Dewerchin M, Carmeliet P, Alitalo K. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Molecular and Cellular Biology. 21: 4647-55. PMID 11416142 DOI: 10.1128/Mcb.21.14.4647-4655.2001 |
0.45 |
|
| 2001 |
Uutela M, Laurén J, Bergsten E, Li X, Horelli-Kuitunen N, Eriksson U, Alitalo K. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes. Circulation. 103: 2242-7. PMID 11342471 DOI: 10.1161/01.Cir.103.18.2242 |
0.395 |
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| 2001 |
Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nature Cell Biology. 3: 512-6. PMID 11331881 DOI: 10.1038/35074588 |
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Iljin K, Karkkainen MJ, Lawrence EC, Kimak MA, Uutela M, Taipale J, Pajusola K, Alhonen L, Halmekytö M, Finegold DN, Ferrell RE, Alitalo K. VEGFR3 gene structure, regulatory region, and sequence polymorphisms. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1028-36. PMID 11292664 DOI: 10.1096/Fj.00-0383Com |
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| 2001 |
Jones N, Iljin K, Dumont DJ, Alitalo K. Tie receptors: new modulators of angiogenic and lymphangiogenic responses Nature Reviews Molecular Cell Biology. 2: 257-267. PMID 11283723 DOI: 10.1038/35067005 |
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| 2001 |
Enholm B, Karpanen T, Jeltsch M, Kubo H, Stenback F, Prevo R, Jackson DG, Yla-Herttuala S, Alitalo K. Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin. Circulation Research. 88: 623-9. PMID 11282897 DOI: 10.1161/01.Res.88.6.623 |
0.502 |
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| 2001 |
Baldwin ME, Catimel B, Nice EC, Roufail S, Hall NE, Stenvers KL, Karkkainen MJ, Alitalo K, Stacker SA, Achen MG. The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. The Journal of Biological Chemistry. 276: 19166-71. PMID 11279005 DOI: 10.1074/Jbc.M100097200 |
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Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, Petrova TV, Kubo H, Thurston G, McDonald DM, Achen MG, Stacker SA, Alitalo K. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. The Embo Journal. 20: 1223-31. PMID 11250889 DOI: 10.1093/Emboj/20.6.1223 |
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| 2001 |
Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, Banerji S, Huarte J, Montesano R, Jackson DG, Orci L, Alitalo K, Christofori G, Pepper MS. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. The Embo Journal. 20: 672-82. PMID 11179212 DOI: 10.1093/Emboj/20.4.672 |
0.435 |
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Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, Pulkkanen KJ, Kauppinen R, Jackson DG, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nature Medicine. 7: 199-205. PMID 11175851 DOI: 10.1038/84651 |
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| 2001 |
Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nature Medicine. 7: 192-8. PMID 11175850 DOI: 10.1038/84643 |
0.385 |
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| 2001 |
Teichert-Kuliszewska K, Maisonpierre PC, Jones N, Campbell AI, Master Z, Bendeck MP, Alitalo K, Dumont DJ, Yancopoulos GD, Stewart DJ. Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. Cardiovascular Research. 49: 659-70. PMID 11166279 DOI: 10.1016/S0008-6363(00)00231-5 |
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Saaristo A, Karpanen T, Alitalo K. Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis. Oncogene. 19: 6122-9. PMID 11156525 DOI: 10.1038/Sj.Onc.1203969 |
0.422 |
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Loo BB, Darwish KK, Vainikka SS, Saarikettu JJ, Vihko PP, Hermonen JJ, Goldman AA, Alitalo KK, Jalkanen MM. Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4. The International Journal of Biochemistry & Cell Biology. 32: 489-97. PMID 10736564 DOI: 10.1016/S1357-2725(99)00145-4 |
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Rehn M, Veikkola T, Kukk-Valdre E, Nakamura H, Ilmonen M, Lombardo CR, Pihlajaniemi T, Alitalo K, Vuori K. Interaction of endostatin with integrins implicated in angiogenesis Proceedings of the National Academy of Sciences. 98: 1024-1029. DOI: 10.1073/Pnas.98.3.1024 |
0.451 |
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| 2001 |
Kitagawa Y, Hokari R, Katoh S, Matsuzaki K, Kawaguchi A, Nagao S, Iwai A, Miyahara T, Itoh K, Miura S, Otani A, Alitalo K. Increased expression of Flt4 (vascular endothelial growth factor receptor-3) in duodenal mucosa of patients with protein-losing enteropathy Gastroenterology. 120: A284. DOI: 10.1016/S0016-5085(08)81410-2 |
0.44 |
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| 2000 |
Hiltunen MO, Laitinen M, Turunen MP, Jeltsch M, Hartikainen J, Rissanen TT, Laukkanen J, Niemi M, Kossila M, Häkkinen TP, Kivelä A, Enholm B, Mansukoski H, Turunen A, Alitalo K, et al. Intravascular Adenovirus-Mediated VEGF-C Gene Transfer Reduces Neointima Formation in Balloon-Denuded Rabbit Aorta Circulation. 102: 2262-2268. PMID 11056103 DOI: 10.1161/01.Cir.102.18.2262 |
0.428 |
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| 2000 |
Lymboussaki A, Achen MG, Stacker SA, Alitalo K. Growth factors regulating lymphatic vessels. Current Topics in Microbiology and Immunology. 251: 75-82. PMID 11036761 DOI: 10.1007/978-3-642-57276-0_10 |
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| 2000 |
Partanen TA, Arola J, Saaristo A, Jussila L, Ora A, Miettinen M, Stacker SA, Achen MG, Alitalo K. VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2087-96. PMID 11023993 DOI: 10.1096/Fj.99-1049Com |
0.499 |
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| 2000 |
Ekman N, Arighi E, Rajantie I, Saharinen P, Ristimäki A, Silvennoinen O, Alitalo K. The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner. Oncogene. 19: 4151-8. PMID 10962576 DOI: 10.1038/Sj.Onc.1203763 |
0.318 |
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| 2000 |
Saaristo A, Partanen TA, Arola J, Jussila L, Hytönen M, Mäkitie A, Vento S, Kaipainen A, Malmberg H, Alitalo K. Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors. The American Journal of Pathology. 157: 7-14. PMID 10880369 DOI: 10.1016/S0002-9440(10)64510-5 |
0.499 |
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| 2000 |
Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN. Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema. Nature Genetics. 25: 153-9. PMID 10835628 DOI: 10.1038/75997 |
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| 2000 |
Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Boström H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, et al. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nature Cell Biology. 2: 302-9. PMID 10806482 DOI: 10.1038/35010579 |
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| 2000 |
Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. The American Journal of Pathology. 156: 1499-504. PMID 10793061 DOI: 10.1016/S0002-9440(10)65021-3 |
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| 2000 |
Achen MG, Roufail S, Domagala T, Catimel B, Nice EC, Geleick DM, Murphy R, Scott AM, Caesar C, Makinen T, Alitalo K, Stacker SA. Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3. European Journal of Biochemistry. 267: 2505-15. PMID 10785369 DOI: 10.1046/J.1432-1327.2000.01257.X |
0.445 |
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| 2000 |
Vuorela P, Helske S, Hornig C, Alitalo K, Weich H, Halmesmäki E. Amniotic fluid--soluble vascular endothelial growth factor receptor-1 in preeclampsia. Obstetrics and Gynecology. 95: 353-7. PMID 10711543 DOI: 10.1016/S0029-7844(99)00565-7 |
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| 2000 |
Olofsson B, Jeltsch M, Eriksson U, Alitalo K. Current biology of VEGF-B and VEGF-C. Current Opinion in Biotechnology. 10: 528-35. PMID 10600689 DOI: 10.1016/S0958-1669(99)00024-5 |
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| 2000 |
Partanen TA, Alitalo K, Miettinen M. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Cancer. 86: 2406-12. PMID 10590384 DOI: 10.1002/(SICI)1097-0142(19991201)86:11<2406::AID-CNCR31>3.0.CO;2-E |
0.371 |
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Kubo H, Fujiwara T, Jussila L, Hashi H, Ogawa M, Shimizu K, Awane M, Sakai Y, Takabayashi A, Alitalo K, Yamaoka Y, Nishikawa S. Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis Blood. 96: 546-553. DOI: 10.1182/Blood.V96.2.546 |
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| 2000 |
Hamada K, Oike Y, Takakura N, Ito Y, Jussila L, Dumont DJ, Alitalo K, Suda T. VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis Blood. 96: 3793-3800. DOI: 10.1182/Blood.V96.12.3793 |
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| 2000 |
Hiltunen M, Laitinen M, Turunen M, Jeltsch M, Hartikainen J, Rissanen T, Laukkanen J, Niemi M, Kossila M, Häkkinen T, ä AK, Enholm B, Mansukoski H, Turunen A, Alitalo K, et al. VEGF-C adenovirus gene transfer reduces intima formation in rabbits Atherosclerosis. 151: 81. DOI: 10.1016/S0021-9150(00)80366-4 |
0.384 |
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| 1999 |
Skobe M, Brown LF, Tognazzi K, Ganju RK, Dezube BJ, Alitalo K, Detmar M. Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma. The Journal of Investigative Dermatology. 113: 1047-53. PMID 10594750 DOI: 10.1046/J.1523-1747.1999.00798.X |
0.509 |
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| 1999 |
Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors. Nature Medicine. 5: 1359-64. PMID 10581076 DOI: 10.1038/70928 |
0.399 |
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| 1999 |
Petrova TV, Makinen T, Alitalo K. Signaling via vascular endothelial growth factor receptors. Experimental Cell Research. 253: 117-30. PMID 10579917 DOI: 10.1006/Excr.1999.4707 |
0.464 |
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| 1999 |
Lymboussaki A, Olofsson B, Eriksson U, Alitalo K. Vascular Endothelial Growth Factor (VEGF) and VEGF-C Show Overlapping Binding Sites in Embryonic Endothelia and Distinct Sites in Differentiated Adult Endothelia Circulation Research. 85: 992-999. PMID 10571529 DOI: 10.1161/01.Res.85.11.992 |
0.483 |
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| 1999 |
Stacker SA, Stenvers K, Caesar C, Vitali A, Domagala T, Nice E, Roufail S, Simpson RJ, Moritz R, Karpanen T, Alitalo K, Achen MG. Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. The Journal of Biological Chemistry. 274: 32127-36. PMID 10542248 DOI: 10.1074/Jbc.274.45.32127 |
0.458 |
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| 1999 |
Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. The Journal of Biological Chemistry. 274: 30896-905. PMID 10521483 DOI: 10.1074/Jbc.274.43.30896 |
0.346 |
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| 1999 |
Marchiò S, Primo L, Pagano M, Palestro G, Albini A, Veikkola T, Cascone I, Alitalo K, Bussolino F. Vascular endothelial growth factor-C stimulates the migration and proliferation of Kaposi's sarcoma cells. The Journal of Biological Chemistry. 274: 27617-22. PMID 10488101 DOI: 10.1074/Jbc.274.39.27617 |
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| 1999 |
Fanburg-Smith JC, Michal M, Partanen TA, Alitalo K, Miettinen M. Papillary intralymphatic angioendothelioma (PILA): a report of twelve cases of a distinctive vascular tumor with phenotypic features of lymphatic vessels. The American Journal of Surgical Pathology. 23: 1004-10. PMID 10478659 DOI: 10.1097/00000478-199909000-00002 |
0.368 |
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| 1999 |
Partanen TA, Makinen T, Arola J, Suda T, Weich HA, Alitalo K. Endothelial Growth Factor Receptors in Human Fetal Heart Circulation. 100: 583-586. PMID 10441093 DOI: 10.1161/01.Cir.100.6.583 |
0.407 |
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| 1999 |
Blaauwgeers HGT, Holtkamp GM, Rutten H, Witmer AN, Koolwijk P, Partanen TA, Alitalo K, Kroon ME, Kijlstra A, Hinsbergh VWMv, Schlingemann RO. Polarized Vascular Endothelial Growth Factor Secretion by Human Retinal Pigment Epithelium and Localization of Vascular Endothelial Growth Factor Receptors on the Inner Choriocapillaris : Evidence for a Trophic Paracrine Relation American Journal of Pathology. 155: 421-428. PMID 10433935 DOI: 10.1016/S0002-9440(10)65138-3 |
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Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K. Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. The Journal of Biological Chemistry. 274: 21217-22. PMID 10409677 DOI: 10.1074/Jbc.274.30.21217 |
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| 1999 |
Tsurusaki T, Kanda S, Sakai H, Kanetake H, Saito Y, Alitalo K, Koji T. Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis. British Journal of Cancer. 80: 309-13. PMID 10390013 DOI: 10.1038/Sj.Bjc.6690356 |
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| 1999 |
Ruohola JK, Valve EM, Karkkainen MJ, Joukov V, Alitalo K, Härkönen PL. Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells Molecular and Cellular Endocrinology. 149: 29-40. PMID 10375015 DOI: 10.1016/S0303-7207(99)00003-9 |
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Veikkola T, Alitalo K. VEGFs, receptors and angiogenesis. Seminars in Cancer Biology. 9: 211-20. PMID 10343072 DOI: 10.1006/Scbi.1998.0091 |
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| 1999 |
Aase K, Lymboussaki A, Kaipainen A, Olofsson B, Alitalo K, Eriksson U. Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 215: 12-25. PMID 10340753 DOI: 10.1002/(Sici)1097-0177(199905)215:1<12::Aid-Dvdy3>3.0.Co;2-N |
0.448 |
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| 1999 |
Vlaykova T, Laurila P, Muhonen T, Hahka-Kemppinen M, Jekunen A, Alitalo K, Pyrhönen S. Prognostic value of tumour vascularity in metastatic melanoma and association of blood vessel density with vascular endothelial growth factor expression. Melanoma Research. 9: 59-68. PMID 10338335 DOI: 10.1097/00008390-199902000-00008 |
0.356 |
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| 1999 |
Valtola R, Salven P, Heikkilä P, Taipale J, Joensuu H, Rehn M, Pihlajaniemi T, Weich H, deWaal R, Alitalo K. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. The American Journal of Pathology. 154: 1381-90. PMID 10329591 DOI: 10.1016/S0002-9440(10)65392-8 |
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| 1999 |
Klefstrom J, Kovanen PE, Somersalo K, Hueber AO, Littlewood T, Evan GI, Greenberg AH, Saksela E, Timonen T, Alitalo K. c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors. Oncogene. 18: 2181-8. PMID 10327064 DOI: 10.1038/Sj.Onc.1202546 |
0.326 |
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| 1999 |
Vuorela-Vepsäläinen P, Alfthan H, Orpana A, Alitalo K, Stenman UH, Halmesmäki E. Vascular endothelial growth factor is bound in amniotic fluid and maternal serum. Human Reproduction (Oxford, England). 14: 1346-51. PMID 10325292 DOI: 10.1093/Humrep/14.5.1346 |
0.33 |
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| 1999 |
Dupin N, Fisher C, Kellam P, Ariad S, Tulliez M, Franck N, Van Marck E, Salmon D, Gorin I, Escande JP, Weiss RA, Alitalo K, Boshoff C. Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma Proceedings of the National Academy of Sciences of the United States of America. 96: 4546-4551. PMID 10200299 DOI: 10.1073/Pnas.96.8.4546 |
0.411 |
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| 1999 |
Wise LM, Veikkola T, Mercer AA, Savory LJ, Fleming SB, Caesar C, Vitali A, Makinen T, Alitalo K, Stacker SA. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proceedings of the National Academy of Sciences of the United States of America. 96: 3071-6. PMID 10077638 DOI: 10.1073/Pnas.96.6.3071 |
0.471 |
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| 1999 |
Breiteneder-Geleff S, Soleiman A, Kowalski H, Horvat R, Amann G, Kriehuber E, Diem K, Weninger W, Tschachler E, Alitalo K, Kerjaschki D. Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium American Journal of Pathology. 154: 385-394. PMID 10027397 DOI: 10.1016/S0002-9440(10)65285-6 |
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| 1999 |
Iljin K, Dube A, Kontusaari S, Korhonen J, Lahtinen I, Oettgen P, Alitalo K. Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 377-86. PMID 9973326 DOI: 10.1096/Fasebj.13.2.377 |
0.435 |
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| 1999 |
Korpelainen EI, Kärkkäinen M, Gunji Y, Vikkula M, Alitalo K. Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. Oncogene. 18: 1-8. PMID 9926914 DOI: 10.1038/Sj.Onc.1202288 |
0.425 |
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| 1999 |
Mancardi S, Stanta G, Dusetti N, Bestagno M, Jussila L, Zweyer M, Lunazzi G, Dumont D, Alitalo K, Burrone OR. Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant. Experimental Cell Research. 246: 368-75. PMID 9925752 DOI: 10.1006/Excr.1998.4270 |
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| 1999 |
Taipale J, Makinen T, Arighi E, Kukk E, Karkkainen M, Alitalo K. Vascular endothelial growth factor receptor-3. Current Topics in Microbiology and Immunology. 237: 85-96. PMID 9893347 DOI: 10.1007/978-3-642-59953-8_5 |
0.403 |
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| 1999 |
Eriksson U, Alitalo K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Current Topics in Microbiology and Immunology. 237: 41-57. PMID 9893345 DOI: 10.1007/978-3-642-59953-8_3 |
0.446 |
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| 1999 |
Korpelainen EI, Karkkainen MJ, Tenhunen A, Lakso M, Rauvala H, Vierula M, Parvinen M, Alitalo K. Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF. The Journal of Cell Biology. 143: 1705-12. PMID 9852161 DOI: 10.1083/Jcb.143.6.1705 |
0.483 |
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| 1998 |
Cao Y, Linden P, Farnebo J, Cao R, Eriksson A, Kumar V, Qi JH, Claesson-Welsh L, Alitalo K. Vascular endothelial growth factor C induces angiogenesis in vivo Proceedings of the National Academy of Sciences of the United States of America. 95: 14389-14394. PMID 9826710 DOI: 10.1073/Pnas.95.24.14389 |
0.492 |
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| 1998 |
Laurén J, Gunji Y, Alitalo K. Is angiopoietin-2 necessary for the initiation of tumor angiogenesis? The American Journal of Pathology. 153: 1333-9. PMID 9811321 DOI: 10.1016/S0002-9440(10)65717-3 |
0.428 |
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| 1998 |
Pepper MS, Mandriota SJ, Jeltsch M, Kumar V, Alitalo K. Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity. Journal of Cellular Physiology. 177: 439-52. PMID 9808152 DOI: 10.1002/(Sici)1097-4652(199812)177:3<439::Aid-Jcp7>3.0.Co;2-2 |
0.506 |
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| 1998 |
Dumont DJ, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science (New York, N.Y.). 282: 946-9. PMID 9794766 DOI: 10.1126/Science.282.5390.946 |
0.468 |
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| 1998 |
Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 11709-11714. PMID 9751730 DOI: 10.1073/Pnas.95.20.11709 |
0.461 |
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| 1998 |
Kim JO, Nau MM, Allikian KA, Mäkelä TP, Alitalo K, Johnson BE, Kelley MJ. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. Oncogene. 17: 1019-26. PMID 9747881 DOI: 10.1038/Sj.Onc.1202006 |
0.301 |
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| 1998 |
Lymboussaki A, Partanen TA, Olofsson B, Thomas-Crusells J, Fletcher CDM, Waal RMWd, Kaipainen A, Alitalo K. Expression of the Vascular Endothelial Growth Factor C Receptor VEGFR-3 in Lymphatic Endothelium of the Skin and in Vascular Tumors American Journal of Pathology. 153: 395-403. PMID 9708800 DOI: 10.1016/S0002-9440(10)65583-6 |
0.465 |
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| 1998 |
Vuorela P, Matikainen MT, Kuusela P, Ylikorkala O, Alitalo K, Halmesmäki E. Endothelial tie receptor antigen in maternal and cord blood of healthy and preeclamptic subjects. Obstetrics and Gynecology. 92: 179-83. PMID 9699747 DOI: 10.1016/S0029-7844(98)00195-1 |
0.337 |
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| 1998 |
Salven P, Lymboussaki A, Heikkilä P, Jääskela-Saari H, Enholm B, Aase K, Euler Gv, Eriksson U, Alitalo K, Joensuu H. Vascular Endothelial Growth Factors VEGF-B and VEGF-C Are Expressed in Human Tumors American Journal of Pathology. 153: 103-108. PMID 9665470 DOI: 10.1016/S0002-9440(10)65550-2 |
0.496 |
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| 1998 |
Kinnula VL, Aito H, Klefstrom J, Alitalo K, Raivio KO. Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro. Cancer Letters. 125: 191-8. PMID 9566715 DOI: 10.1016/S0304-3835(97)00511-9 |
0.321 |
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| 1998 |
Korpelainen EI, Alitalo K. Signaling angiogenesis and lymphangiogenesis. Current Opinion in Cell Biology. 10: 159-64. PMID 9561839 DOI: 10.1016/S0955-0674(98)80137-3 |
0.375 |
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| 1998 |
Ristimäki A, Narko K, Enholm B, Joukov V, Alitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. The Journal of Biological Chemistry. 273: 8413-8. PMID 9525952 DOI: 10.1074/Jbc.273.14.8413 |
0.458 |
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| 1998 |
Joukov V, Kumar V, Sorsa T, Arighi E, Weich H, Saksela O, Alitalo K. A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. The Journal of Biological Chemistry. 273: 6599-602. PMID 9506953 DOI: 10.1074/Jbc.273.12.6599 |
0.485 |
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| 1998 |
Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) Proceedings of the National Academy of Sciences of the United States of America. 95: 548-553. PMID 9435229 DOI: 10.1073/Pnas.95.2.548 |
0.452 |
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| 1998 |
Klefstrom J, Arighi E, Littlewood T, Jäättelä M, Saksela E, Evan GI, Alitalo K. Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation. The Embo Journal. 16: 7382-92. PMID 9405367 DOI: 10.1093/Emboj/16.24.7382 |
0.329 |
|
| 1998 |
Wartiovaara U, Salven P, Mikkola H, Lassila R, Kaukonen J, Joukov V, Orpana A, Ristimäki A, Heikinheimo M, Joensuu H, Alitalo K, Palotie A. Peripheral Blood Platelets Express VEGF-C and VEGF which Are Released during Platelet Activation Thrombosis and Haemostasis. 80: 171-175. DOI: 10.1055/S-0037-1615158 |
0.466 |
|
| 1998 |
Alitalo K. Vascular endothelial growth factors and receptors involved in angiogenesis and lymphangiogenesis Pathophysiology. 5: 168. DOI: 10.1016/S0928-4680(98)80944-9 |
0.348 |
|
| 1997 |
Loughna S, Hardman P, Landels E, Jussila L, Alitalo K, Woolf AS. A molecular and genetic analysis of renalglomerular capillary development. Angiogenesis. 1: 84-101. PMID 14517396 DOI: 10.1023/A:1018357116559 |
0.443 |
|
| 1997 |
Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K. Vascular endothelial growth factors VEGF-B and VEGF-C. Journal of Cellular Physiology. 173: 211-5. PMID 9365524 DOI: 10.1002/(Sici)1097-4652(199711)173:2<211::Aid-Jcp23>3.0.Co;2-H |
0.479 |
|
| 1997 |
Ekman N, Lymboussaki A, Västrik I, Sarvas K, Kaipainen A, Alitalo K. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Circulation. 96: 1729-32. PMID 9323053 DOI: 10.1161/01.Cir.96.6.1729 |
0.347 |
|
| 1997 |
Chilov D, Kukk E, Taira S, Jeltsch M, Kaukonen J, Palotie A, Joukov V, Alitalo K. Genomic organization of human and mouse genes for vascular endothelial growth factor C. The Journal of Biological Chemistry. 272: 25176-83. PMID 9312130 DOI: 10.1074/Jbc.272.40.25176 |
0.465 |
|
| 1997 |
Oh SJ, Jeltsch MM, Birkenhäger R, McCarthy JE, Weich HA, Christ B, Alitalo K, Wilting J. VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Developmental Biology. 188: 96-109. PMID 9245515 DOI: 10.1006/Dbio.1997.8639 |
0.496 |
|
| 1997 |
Joukov V, Sorsa T, Kumar V, Jeltsch M, Claesson‐Welsh L, Cao Y, Saksela O, Kalkkinen N, Alitalo K. Proteolytic processing regulates receptor specificity and activity of VEGF‐C The Embo Journal. 16: 3898-3911. PMID 9233800 DOI: 10.1093/Emboj/16.13.3898 |
0.478 |
|
| 1997 |
Kukk E, Wartiovaara U, Gunji Y, Kaukonen J, Bühring HJ, Rappold I, Matikainen MT, Vihko P, Partanen J, Palotie A, Alitalo K, Alitalo R. Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells. British Journal of Haematology. 98: 195-203. PMID 9233584 DOI: 10.1046/J.1365-2141.1997.1732989.X |
0.361 |
|
| 1997 |
Enholm B, Paavonen K, Ristimäki A, Kumar V, Gunji Y, Klefstrom J, Kivinen L, Laiho M, Olofsson B, Joukov V, Eriksson U, Alitalo K. Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia Oncogene. 14: 2475-2483. PMID 9188862 DOI: 10.1038/Sj.Onc.1201090 |
0.469 |
|
| 1997 |
Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (New York, N.Y.). 276: 1423-5. PMID 9162011 DOI: 10.1126/Science.276.5317.1423 |
0.49 |
|
| 1997 |
Vuorela P, Hatva E, Lymboussaki A, Kaipainen A, Joukov V, Persico MG, Alitalo K, Halmesmäki E. Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biology of Reproduction. 56: 489-94. PMID 9116151 DOI: 10.1095/Biolreprod56.2.489 |
0.492 |
|
| 1997 |
Hatva E, Jääskeläinen J, Hirvonen H, Alitalo K, Haltia M. Tie endothelial cell-specific receptor tyrosine kinase is upregulated in the vasculature of arteriovenous malformations. Journal of Neuropathology and Experimental Neurology. 55: 1124-33. PMID 8939195 DOI: 10.1097/00005072-199611000-00003 |
0.476 |
|
| 1997 |
Saharinen P, Ekman N, Sarvas K, Parker P, Alitalo K, Silvennoinen O. The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ Blood. 90: 4341-4353. DOI: 10.1182/Blood.V90.11.4341.4341_4341_4353 |
0.301 |
|
| 1997 |
Alitalo K. Vascular endothelial growth factors and receptors involved in angiogenesis and lymphangiogenesis European Journal of Cancer. 33: S224. DOI: 10.1016/S0959-8049(97)85783-8 |
0.348 |
|
| 1996 |
Olofsson B, Pajusola K, von Euler G, Chilov D, Alitalo K, Eriksson U. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. The Journal of Biological Chemistry. 271: 19310-7. PMID 8702615 DOI: 10.1074/Jbc.271.32.19310 |
0.455 |
|
| 1996 |
Salvén P, Joensuu H, Heikkilä P, Matikainen MT, Wasenius VM, Alanko A, Alitalo K. Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis. British Journal of Cancer. 74: 69-72. PMID 8679461 DOI: 10.1038/Bjc.1996.317 |
0.354 |
|
| 1996 |
Paavonen K, Horelli-Kuitunen N, Chilov D, Kukk E, Pennanen S, Kallioniemi OP, Pajusola K, Olofsson B, Eriksson U, Joukov V, Palotie A, Alitalo K. Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. Circulation. 93: 1079-82. PMID 8653826 DOI: 10.1161/01.Cir.93.6.1079 |
0.484 |
|
| 1996 |
Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 2576-81. PMID 8637916 DOI: 10.1073/Pnas.93.6.2576 |
0.465 |
|
| 1996 |
Böhling T, Hatva E, Kujala M, Claesson-Welsh L, Alitalo K, Haltia M. Expression of growth factors and growth factor receptors in capillary hemangioblastoma. Journal of Neuropathology and Experimental Neurology. 55: 522-7. PMID 8627342 DOI: 10.1097/00005072-199605000-00004 |
0.447 |
|
| 1996 |
Batard P, Sansilvestri P, Scheinecker C, Knapp W, Debili N, Vainchenker W, Buhring H, Monier M, Kukk E, Partanen J, Matikainen M, Alitalo R, Hatzfeld J, Alitalo K. The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells Blood. 87: 2212-2220. DOI: 10.1182/Blood.V87.6.2212.Bloodjournal8762212 |
0.338 |
|
| 1996 |
Kaukonen J, Lahtinen I, Laine S, Alitalo K, Palotie A. BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias. British Journal of Haematology. 94: 455-460. DOI: 10.1111/J.1365-2141.1996.Tb00091.X |
0.318 |
|
| 1996 |
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. The Embo Journal. 15: 1751-1751. DOI: 10.1002/J.1460-2075.1996.Tb00359.X |
0.501 |
|
| 1995 |
Puri MC, Rossant J, Alitalo K, Bernstein A, Partanen J. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells Embo Journal. 14: 5884-5891. PMID 8846781 DOI: 10.1002/J.1460-2075.1995.Tb00276.X |
0.48 |
|
| 1995 |
Västrik I, Kaipainen A, Penttilä TL, Lymboussakis A, Alitalo R, Parvinen M, Alitalo K. Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. The Journal of Cell Biology. 128: 1197-208. PMID 7896882 DOI: 10.1083/Jcb.128.6.1197 |
0.374 |
|
| 1995 |
Kaipainen A, Korhonen J, Mustonen T, van Hinsbergh VW, Fang GH, Dumont D, Breitman M, Alitalo K. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proceedings of the National Academy of Sciences of the United States of America. 92: 3566-70. PMID 7724599 DOI: 10.1073/Pnas.92.8.3566 |
0.448 |
|
| 1995 |
Dumont DJ, Fong GH, Puri MC, Gradwohl G, Alitalo K, Breitman ML. Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 203: 80-92. PMID 7647376 DOI: 10.1002/Aja.1002030109 |
0.468 |
|
| 1995 |
Mustonen T, Alitalo K. Endothelial receptor tyrosine kinases involved in angiogenesis. The Journal of Cell Biology. 129: 895-8. PMID 7538139 DOI: 10.1083/Jcb.129.4.895 |
0.387 |
|
| 1995 |
Ruohola JK, Valve EM, Vainikka S, Alitalo K, Härkönen PL. Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells. Endocrinology. 136: 2179-88. PMID 7536664 DOI: 10.1210/Endo.136.5.7536664 |
0.363 |
|
| 1995 |
Bergman M, Joukov V, Virtanen I, Alitalo K. Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading. Molecular and Cellular Biology. 15: 711-22. PMID 7529872 DOI: 10.1128/Mcb.15.2.711 |
0.335 |
|
| 1995 |
Korhonen J, Lahtinen I, Halmekyto M, Alhonen L, Janne J, Dumont D, Alitalo K. Endothelial-specific gene expression directed by the tie gene promoter in vivo Blood. 86: 1828-1835. DOI: 10.1182/Blood.V86.5.1828.Bloodjournal8651828 |
0.414 |
|
| 1994 |
Philipp A, Schneider A, Väsrik I, Finke K, Xiong Y, Beach D, Alitalo K, Eilers M. Repression of cyclin D1: a novel function of MYC. Molecular and Cellular Biology. 14: 4032-43. PMID 8196642 DOI: 10.1128/Mcb.14.6.4032 |
0.301 |
|
| 1994 |
Västrik I, Mäkelä TP, Koskinen PJ, Klefstrom J, Alitalo K. Myc protein: partners and antagonists. Critical Reviews in Oncogenesis. 5: 59-68. PMID 7948108 DOI: 10.1615/Critrevoncog.V5.I1.30 |
0.362 |
|
| 1994 |
Klefstrom J, Västrik I, Saksela E, Valle J, Eilers M, Alitalo K. c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha. The Embo Journal. 13: 5442-5450. DOI: 10.1002/J.1460-2075.1994.Tb06879.X |
0.333 |
|
| 1993 |
Pertovaara L, Saksela O, Alitalo K. Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells. Growth Factors (Chur, Switzerland). 9: 81-6. PMID 8347352 DOI: 10.3109/08977199308991584 |
0.332 |
|
| 1993 |
Kaipainen A, Korhonen J, Pajusola K, Aprelikova O, Persico MG, Terman BI, Alitalo K. The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells. The Journal of Experimental Medicine. 178: 2077-88. PMID 8245783 DOI: 10.1084/Jem.178.6.2077 |
0.49 |
|
| 1993 |
Koskinen PJ, Mäkelä TP, Västrik I, Alitalo K. Myc amplification: regulation of myc function. Clinica Chimica Acta; International Journal of Clinical Chemistry. 217: 57-62. PMID 8222283 DOI: 10.1016/0009-8981(93)90237-X |
0.357 |
|
| 1993 |
Partanen J, Vainikka S, Alitalo K. Structural and functional specificity of FGF receptors. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 340: 297-303. PMID 8103932 DOI: 10.1098/Rstb.1993.0071 |
0.342 |
|
| 1993 |
Mummery CL, Vanrooyen M, Bracke M, Vandeneijndenvanraaij J, Vanzoelen EJ, Alitalo K. Fibroblast Growth Factor-Mediated Growth Regulation and Receptor Expression in Embryonal Carcinoma and Embryonic Stem Cells and Human Germ Cell Tumors Biochemical and Biophysical Research Communications. 191: 188-195. PMID 7680555 DOI: 10.1006/Bbrc.1993.1201 |
0.342 |
|
| 1993 |
Pertovaara L, Tienari J, Vainikka S, Partanen J, Saksela O, Lehtonen E, Alitalo K. Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells. Biochemical and Biophysical Research Communications. 191: 149-56. PMID 7680553 DOI: 10.1006/Bbrc.1993.1196 |
0.356 |
|
| 1992 |
Mäkelä TP, Saksela K, Alitalo K. Amplification and rearrangement of L-myc in human small-cell lung cancer. Mutation Research. 276: 307-15. PMID 1374523 DOI: 10.1016/0165-1110(92)90017-4 |
0.305 |
|
| 1992 |
Lehtola L, Lehväslaiho H, Koskinen P, Alitalo K. A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein. Acta Oncologica (Stockholm, Sweden). 31: 147-50. PMID 1352454 DOI: 10.3109/02841869209088895 |
0.307 |
|
| 1992 |
Partanen J, Vainikka S, Korhonen J, Armstrong E, Alitalo K. Diverse receptors for fibroblast growth factors. Progress in Growth Factor Research. 4: 69-83. PMID 1325208 DOI: 10.1016/0955-2235(92)90005-3 |
0.382 |
|
| 1992 |
Korhonen J, Partanen J, Eerola E, Vainikka S, Alitalo R, Mäkelä TP, Sandberg M, Hirvonen H, Alitalo K. Five FGF receptors with distinct expression patterns. Exs. 61: 91-100. PMID 1319781 DOI: 10.1007/978-3-0348-7001-6_16 |
0.386 |
|
| 1992 |
Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Molecular and Cellular Biology. 12: 1698-707. PMID 1312667 DOI: 10.1128/Mcb.12.4.1698 |
0.461 |
|
| 1992 |
Lehtola L, Partanen J, Sistonen L, Korhonen J, Wärri A, Härkönen P, Clarke R, Alitalo K. Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells. International Journal of Cancer. 50: 598-603. PMID 1311287 DOI: 10.1002/Ijc.2910500419 |
0.36 |
|
| 1992 |
Korhonen J, Partanen J, Alitalo K. Expression of FGFR-4 mRNA in developing mouse tissues. The International Journal of Developmental Biology. 36: 323-329. DOI: 10.1387/Ijdb.1326315 |
0.307 |
|
| 1992 |
Korhonen J, Partanen J, Armstrong E, Vaahtokari A, Elenius K, Jalkanen M, Alitalo K. Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization Blood. 80: 2548-2555. DOI: 10.1182/Blood.V80.10.2548.Bloodjournal80102548 |
0.404 |
|
| 1992 |
Vainikka S, Partanen J, Bellosta P, Coulier F, Birnbaum D, Basilico C, Jaye M, Alitalo K. Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. The Embo Journal. 11: 4273-4280. DOI: 10.1002/J.1460-2075.1992.Tb05526.X |
0.342 |
|
| 1991 |
Partanen J, Mäkelä TP, Alitalo R, Lehväslaiho H, Alitalo K. Putative tyrosine kinases expressed in K-562 human leukemia cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 8913-7. PMID 2247464 DOI: 10.1073/Pnas.87.22.8913 |
0.341 |
|
| 1991 |
Bianchi NO, Bianchi MS, Alitalo K, De La Chapelle A. UV damage and repair in the domain of the human c-myc oncogene. Dna and Cell Biology. 10: 125-32. PMID 2003876 DOI: 10.1089/Dna.1991.10.125 |
0.315 |
|
| 1991 |
Lehtola L, Sistonen L, Koskinen P, Lehväslaiho H, Di Renzo MF, Comoglio PM, Alitalo K. Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation. Journal of Cellular Biochemistry. 45: 69-81. PMID 1706346 DOI: 10.1002/Jcb.240450114 |
0.361 |
|
| 1991 |
Lehtola L, Nistér M, Hölttä E, Westermark B, Alitalo K. Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase. Cell Regulation. 2: 651-61. PMID 1685673 DOI: 10.1091/Mbc.2.8.651 |
0.346 |
|
| 1991 |
Armstrong E, Hästbacka J, Partanen J, Huebner K, Alitalo K. RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter. Nucleic Acids Research. 19: 5096. PMID 1681501 DOI: 10.1093/Nar/19.18.5096-A |
0.31 |
|
| 1991 |
Koskinen PJ, Sistonen L, Evan G, Morimoto R, Alitalo K. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. Journal of Virology. 65: 842-851. DOI: 10.1128/Jvi.65.2.842-851.1991 |
0.322 |
|
| 1991 |
Partanen J, Mäkelä T, Eerola E, Korhonen J, Hirvonen H, Claesson-Welsh L, Alitalo K. FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. The Embo Journal. 10: 1347-1354. DOI: 10.1002/J.1460-2075.1991.Tb07654.X |
0.361 |
|
| 1991 |
Mäkelä T, Saksela K, Evan G, Alitalo K. A fusion protein formed by L-myc and a novel gene in SCLC. The Embo Journal. 10: 1331-1335. DOI: 10.1002/J.1460-2075.1991.Tb07652.X |
0.301 |
|
| 1990 |
Laitinen J, Sistonen L, Alitalo K, Hölttä E. c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts. The Journal of Cell Biology. 111: 9-17. PMID 2195041 DOI: 10.1083/Jcb.111.1.9 |
0.311 |
|
| 1990 |
Lehväslaiho H, Sistonen L, diRenzo F, Partanen J, Comoglio P, Hölttä E, Alitalo K. Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase. Journal of Cellular Biochemistry. 42: 123-33. PMID 1969420 DOI: 10.1002/Jcb.240420303 |
0.333 |
|
| 1990 |
Alitalo R, Partanen J, Pertovaara L, Holtta E, Sistonen L, Andersson L, Alitalo K. Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells Blood. 75: 1974-1982. DOI: 10.1182/Blood.V75.10.1974.1974 |
0.336 |
|
| 1989 |
Lehtola L, Lehväslaiho H, Sistonen L, Beguinot L, Alitalo K. Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera. Growth Factors (Chur, Switzerland). 1: 323-34. PMID 2699432 DOI: 10.3109/08977198909000256 |
0.337 |
|
| 1989 |
Mäkelä TP, Saksela K, Alitalo K. Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene. Molecular and Cellular Biology. 9: 1545-52. PMID 2657399 DOI: 10.1128/Mcb.9.4.1545 |
0.301 |
|
| 1989 |
Bianchi NO, Bianchi MS, Alitalo K, de la Chapelle A. The methylation pattern of normal and truncated amplified human c-myc oncogenes. Biochimica Et Biophysica Acta. 1007: 350-5. PMID 2649153 DOI: 10.1016/0167-4781(89)90158-9 |
0.316 |
|
| 1989 |
Sistonen L, Hölttä E, Lehväslaiho H, Lehtola L, Alitalo K. Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase. The Journal of Cell Biology. 109: 1911-9. PMID 2572601 DOI: 10.1083/Jcb.109.5.1911 |
0.359 |
|
| 1989 |
Saksela K, Mäkelä TP, Alitalo K. Oncogene expression in small-cell lung cancer cell lines and a testicular germ-cell tumor: activation of the N-myc gene and decreased RB mRNA. International Journal of Cancer. 44: 182-5. PMID 2545635 DOI: 10.1002/Ijc.2910440132 |
0.333 |
|
| 1989 |
Hirvonen H, Sandberg M, Kalimo H, Hukkanen V, Vuorio E, Salmi TT, Alitalo K. The N-myc proto-oncogene and IGF-II growth factor mRNAs are expressed by distinct cells in human fetal kidney and brain. The Journal of Cell Biology. 108: 1093-104. PMID 2537832 DOI: 10.1083/Jcb.108.3.1093 |
0.303 |
|
| 1989 |
Sihvola M, Sistonen L, Alitalo K, Hurme M. Mechanism of T cell proliferation in vivo: analysis of IL-2 receptor expression and activation of c-myc and c-myb oncogenes during lymphatic regeneration. Biochemical and Biophysical Research Communications. 160: 181-8. PMID 2496686 DOI: 10.1016/0006-291X(89)91638-0 |
0.306 |
|
| 1989 |
Sistonen L, Hölttä E, Mäkelä TP, Keski-Oja J, Alitalo K. The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression. The Embo Journal. 8: 815-822. DOI: 10.1002/J.1460-2075.1989.Tb03442.X |
0.301 |
|
| 1989 |
Lehväslaiho H, Lehtola L, Sistonen L, Alitalo K. A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. The Embo Journal. 8: 159-166. DOI: 10.1002/J.1460-2075.1989.Tb03360.X |
0.347 |
|
| 1989 |
Saksela K, Mäkelä TP, Evan G, Alitalo K. Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum. The Embo Journal. 8: 149-157. DOI: 10.1002/J.1460-2075.1989.Tb03359.X |
0.314 |
|
| 1988 |
Mäkelä TP, Alitalo R, Paulsson Y, Westermark B, Heldin CH, Alitalo K. Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines. Molecular and Cellular Biology. 7: 3656-62. PMID 3479682 DOI: 10.1128/Mcb.7.10.3656 |
0.349 |
|
| 1987 |
Sistonen L, Keski-Oja J, Ulmanen I, Hölttä E, Wikgren BJ, Alitalo K. Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones. Experimental Cell Research. 168: 518-30. PMID 3803452 DOI: 10.1016/0014-4827(87)90024-3 |
0.312 |
|
| 1987 |
Schwab M, Klempnauer KH, Alitalo K, Varmus H, Bishop M. Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription. Molecular and Cellular Biology. 6: 2752-5. PMID 3785211 DOI: 10.1128/Mcb.6.7.2752 |
0.623 |
|
| 1987 |
Alhonen-Hongisto L, Leinonen P, Sinervirta R, Laine R, Winqvist R, Alitalo K, Jänne OA, Jänne J. Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification. The Biochemical Journal. 242: 205-10. PMID 3036086 DOI: 10.1042/Bj2420205 |
0.314 |
|
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