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Lei Liu - Publications

Affiliations: 
Harvard Medical School - BWH 
Area:
Alzheimer's disease
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bellier JP, Cai Y, Alam SM, Wiederhold T, Aiello A, Vogelgsang JS, Berretta S, Chhatwal JP, Selkoe DJ, Liu L. Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38041855 DOI: 10.1002/alz.13557  0.493
2023 Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E. Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37438872 DOI: 10.1002/alz.13382  0.566
2023 Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, et al. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell. e13871. PMID 37291760 DOI: 10.1111/acel.13871  0.305
2023 Stern AM, Yang Y, Jin S, Yamashita K, Meunier AL, Liu W, Cai Y, Ericsson M, Liu L, Goedert M, Scheres SHW, Selkoe DJ. Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains. Neuron. PMID 37167969 DOI: 10.1016/j.neuron.2023.04.007  0.514
2023 Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E. Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts. Medrxiv : the Preprint Server For Health Sciences. PMID 36945447 DOI: 10.1101/2023.03.10.23287109  0.639
2023 Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, et al. Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. Npj Parkinson's Disease. 9: 4. PMID 36646701 DOI: 10.1038/s41531-023-00444-w  0.678
2022 Hsieh YC, Negri J, He A, Pearse RV, Liu L, Duong DM, Chibnik LB, Bennett DA, Seyfried NT, Young-Pearse TL. Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity. Molecular Neurodegeneration. 17: 61. PMID 36131294 DOI: 10.1186/s13024-022-00558-4  0.644
2022 Jin SX, Liu L, Li S, Meunier AL, Selkoe DJ. Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this. Neurobiology of Disease. 172: 105816. PMID 35820646 DOI: 10.1016/j.nbd.2022.105816  0.449
2022 Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, et al. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. Npj Parkinson's Disease. 8: 74. PMID 35680956 DOI: 10.1038/s41531-022-00335-6  0.63
2022 Liu L, Cai Y, Lauro BM, Meunier AL, Chhatwal J, Selkoe DJ. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration. Biochemical and Biophysical Research Communications. 611: 85-90. PMID 35483223 DOI: 10.1016/j.bbrc.2022.04.077  0.448
2022 Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35278341 DOI: 10.1002/alz.12646  0.714
2022 de Boni L, Watson AH, Zaccagnini L, Wallis A, Zhelcheska K, Kim N, Sanderson J, Jiang H, Martin E, Cantlon A, Rovere M, Liu L, Sylvester M, Lashley T, Dettmer U, et al. Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations. Acta Neuropathologica. PMID 35141810 DOI: 10.1007/s00401-022-02406-7  0.647
2022 Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U. Pathogenic mechanisms of cytosolic and membrane-enriched α-synuclein converge on fatty acid homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35086904 DOI: 10.1523/JNEUROSCI.1881-21.2022  0.6
2022 Stern AM, Liu L, Jin S, Liu W, Meunier AL, Ericsson M, Miller MB, Batson M, Sun T, Kathuria S, Reczek D, Pradier L, Selkoe DJ. A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain. Brain : a Journal of Neurology. PMID 35084489 DOI: 10.1093/brain/awac023  0.495
2022 Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, et al. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 21: 140-152. PMID 35065037 DOI: 10.1016/S1474-4422(21)00375-6  0.301
2021 Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34550630 DOI: 10.1002/alz.12457  0.486
2021 Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, et al. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. PMID 34473944 DOI: 10.1016/j.neuron.2021.08.003  0.692
2021 Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Reports. 36: 109333. PMID 34233191 DOI: 10.1016/j.celrep.2021.109333  0.397
2021 Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. The Journal of Biological Chemistry. 100393. PMID 33571524 DOI: 10.1016/j.jbc.2021.100393  0.484
2021 Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M. Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. Journal of Alzheimer's Disease : Jad. PMID 33492290 DOI: 10.3233/JAD-201174  0.32
2020 Shen Q, Liu L, Gu X, Xing D. Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease. Aging Cell. e13289. PMID 33336891 DOI: 10.1111/acel.13289  0.304
2020 Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nature Communications. 11: 6024. PMID 33247134 DOI: 10.1038/s41467-020-19543-w  0.549
2020 Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nature Communications. 11: 6024. PMID 33247134 DOI: 10.1038/s41467-020-19543-w  0.549
2020 Li C, Wang J, Liu L. Alzheimer's Therapeutic Strategy: Photoactive Platforms for Suppressing the Aggregation of Amyloid β Protein. Frontiers in Chemistry. 8: 509. PMID 32793545 DOI: 10.3389/fchem.2020.00509  0.325
2019 Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiology of Aging. PMID 31500908 DOI: 10.1016/J.Neurobiolaging.2019.07.002  0.416
2019 Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiology of Aging. PMID 31500908 DOI: 10.1016/J.Neurobiolaging.2019.07.002  0.416
2019 Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31416794 DOI: 10.1016/J.Jalz.2019.06.3918  0.458
2019 Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31416794 DOI: 10.1016/J.Jalz.2019.06.3918  0.458
2019 Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. The Journal of Cell Biology. PMID 30626721 DOI: 10.1083/Jcb.201806205  0.463
2019 Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. The Journal of Cell Biology. PMID 30626721 DOI: 10.1083/Jcb.201806205  0.463
2019 Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. P1-218: A NOVEL CELLULAR COMPLEX OF BACE1 AND γ-SECRETASE SEQUENTIALLY GENERATES Aβ FROM APP Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.773  0.425
2018 Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathologica Communications. 6: 121. PMID 30409172 DOI: 10.1186/S40478-018-0626-X  0.537
2018 Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathologica Communications. 6: 121. PMID 30409172 DOI: 10.1186/S40478-018-0626-X  0.537
2016 Liu L, Watanabe N, Akatsu H, Nishimura M. Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. PMID 27256505 DOI: 10.1016/J.Neuroscience.2016.05.050  0.305
2016 Ochiishi T, Itakura A, Liu L, Akatsu H, Kohno H, Nishimura M, Yoshimune K. Immunohistochemical detection of the delayed formation of nonfibrillar large amyloid-β aggregates. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 21: 200-11. PMID 26805741 DOI: 10.1111/gtc.12332  0.314
2014 Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M. The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor. Nature Communications. 5: 3917. PMID 24894631 DOI: 10.1038/Ncomms4917  0.305
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