Thomas Baukrowitz - Publications

Affiliations: 
Physiology Christian-Albrechts-Universität zu Kiel, Kiel, Schleswig-Holstein, Germany 

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Chang WW, Matt AS, Schewe M, Musinszki M, Grüssel S, Brandenburg J, Garfield D, Bleich M, Baukrowitz T, Hu MY. An otopetrin family proton channel promotes cellular acid efflux critical for biomineralization in a marine calcifier. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34301868 DOI: 10.1073/pnas.2101378118  0.439
2021 Proks P, Schewe M, Conrad LJ, Rao S, Rathje K, Rödström KEJ, Carpenter EP, Baukrowitz T, Tucker SJ. Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate. The Journal of General Physiology. 153. PMID 34032848 DOI: 10.1085/jgp.202012812  0.759
2019 Nematian-Ardestani E, Abd-Wahab MF, Chatelain FC, Sun H, Schewe M, Baukrowitz T, Tucker SJ. Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ Channel. The Journal of Biological Chemistry. PMID 31806709 DOI: 10.1074/Jbc.Ra119.010612  0.756
2019 Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, Gonzalez W, Decher N. The molecular basis for an allosteric inhibition of K-flux gating in K channels. Elife. 8. PMID 30803485 DOI: 10.7554/eLife.39476  0.592
2019 Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, ... ... Baukrowitz T, et al. A pharmacological master key mechanism that unlocks the selectivity filter gate in K channels. Science (New York, N.Y.). 363: 875-880. PMID 30792303 DOI: 10.1126/Science.Aav0569  0.75
2019 Schewe M, Sun H, Mackenzie A, Pike ACW, Schulz F, Constantin C, Kiper AK, Conrad LJ, Gonzalez W, Groot BLd, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T. A Pharmacological Masterkey Mechanism to Unlock the Selectivity Filter Gate in K+ Channels Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1635  0.706
2018 Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, ... ... Baukrowitz T, et al. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800246R. PMID 29879376 DOI: 10.1096/fj.201800246R  0.375
2017 Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike AC, Carpenter EP, Baukrowitz T, Sansom MS, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure (London, England : 1993). PMID 28392258 DOI: 10.1016/J.Str.2017.03.006  0.717
2017 Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, et al. Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia. Embo Molecular Medicine. PMID 28242754 DOI: 10.15252/Emmm.201606690  0.571
2016 McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. The Journal of General Physiology. 147: 497-505. PMID 27241700 DOI: 10.1085/Jgp.201611601  0.761
2016 Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, de Groot BL, Tucker SJ, Rapedius M, Baukrowitz T. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. Cell. 164: 937-49. PMID 26919430 DOI: 10.1016/J.Cell.2016.02.002  0.755
2016 McClenaghan C, Schewe M, Baukrowitz T, Tucker SJ. Polymodal Gating of the TREK-2 K2P Potassium Channel Involves Structurally Distinct Open States Biophysical Journal. 110: 607. DOI: 10.1016/J.Bpj.2015.11.3241  0.78
2016 Schewe M, Nematian-Ardestani E, Sun H, Musinszki M, Cordeiro S, Bucci G, Groot BLd, Tucker SJ, Rapedius M, Baukrowitz T. A non-canonical voltage sensor controls gating in K2P K+ channels. Biophysical Journal. 110: 937-949. DOI: 10.1016/J.Bpj.2015.11.1502  0.754
2015 Schewe M, Nematian-Ardestani E, Linke T, Benndorf K, Tucker SJ, Rapedius M, Baukrowitz T. Sensing the Electrochemical K+ Gradient: The Voltage Gating Mechanism in K2P Potassium Channels Biophysical Journal. 108: 427. DOI: 10.1016/J.Bpj.2014.11.2338  0.763
2014 Fowler PW, Bollepalli MK, Rapedius M, Nematian-Ardestani E, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Insights into the structural nature of the transition state in the Kir channel gating pathway. Channels (Austin, Tex.). 8: 551-5. PMID 25483285 DOI: 10.4161/19336950.2014.962371  0.723
2014 Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. State-dependent network connectivity determines gating in a K+ channel. Structure (London, England : 1993). 22: 1037-46. PMID 24980796 DOI: 10.1016/J.Str.2014.04.018  0.752
2014 Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MSP, Tucker SJ, Baukrowitz T. Structural and Thermodynamic Characterization of the Gating Pathway in a K+ Channel Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.888  0.768
2014 Schewe M, Rapedius M, Nematian-Ardestani E, Linke T, Benndorf K, Tucker SJ, Baukrowitz T. A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4109  0.757
2013 Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition. Nature Chemical Biology. 9: 507-13. PMID 23728494 DOI: 10.1038/Nchembio.1271  0.55
2012 Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin, Tex.). 6: 473-8. PMID 22991046 DOI: 10.4161/Chan.22153  0.667
2012 Bista P, Meuth SG, Kanyshkova T, Cerina M, Pawlowski M, Ehling P, Landgraf P, Borsotto M, Heurteaux C, Pape HC, Baukrowitz T, Budde T. Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons. PflüGers Archiv : European Journal of Physiology. 463: 89-102. PMID 22083644 DOI: 10.1007/S00424-011-1056-9  0.434
2012 Rapedius M, Piechotta PL, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T. Structural and Mechanistic Insights into Gating of K2P Channels Biophysical Journal. 102: 121a. DOI: 10.1016/J.Bpj.2011.11.678  0.794
2011 Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Erhlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ, Baukrowitz T. The pore structure and gating mechanism of K2P channels. The Embo Journal. 30: 3607-19. PMID 21822218 DOI: 10.1038/Emboj.2011.268  0.792
2011 Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Ehrlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MSP, Tucker SJ, Baukrowitz T. The pore structure and gating mechanism of K2P channels The Embo Journal. 30: 4515-4515. DOI: 10.1038/EMBOJ.2011.369  0.641
2011 Schmidt MR, Stansfeld PJ, Rapedius M, Baukrowitz T, Tucker SJ, Sansom MS. PIP2-Binding to an Open State Model of Kir1.1 Probed by Multiscale Biomolecular Simulations Biophysical Journal. 100: 431a. DOI: 10.1016/J.Bpj.2010.12.2547  0.717
2011 Sharma C, Bollepalli MK, Baukrowitz T, Tucker SJ. Identification of Gating Mutations in the Trek-1 k2p Potassium Channel by Functional Complementation in K+ uptake Deficient Yeast Biophysical Journal. 100: 279a-280a. DOI: 10.1016/J.Bpj.2010.12.1734  0.737
2010 Paynter JJ, Shang L, Bollepalli MK, Baukrowitz T, Tucker SJ. Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels. Channels (Austin, Tex.). 4: 390-7. PMID 20699659 DOI: 10.4161/Chan.4.5.13006  0.666
2010 Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, ... Baukrowitz T, et al. RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. The Embo Journal. 29: 2101-13. PMID 20461057 DOI: 10.1038/emboj.2010.88  0.588
2010 Kurata HT, Rapedius M, Kleinman MJ, Baukrowitz T, Nichols CG. Voltage-dependent gating in a "voltage sensor-less" ion channel. Plos Biology. 8: e1000315. PMID 20208975 DOI: 10.1371/journal.pbio.1000315  0.604
2010 Li X, Rapedius M, Baukrowitz T, Liu GX, Srivastava DK, Daut J, Hanley PJ. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochimica Et Biophysica Acta. 1800: 385-91. PMID 19931596 DOI: 10.1016/j.bbagen.2009.11.012  0.445
2010 Bollepalli MK, Fowler P, Rapedius M, Xie M, Shang L, Fritzenschaft H, Sansom M, Tucker SJ, Baukrowitz T. A Structural Model of a Kir Channel in the Open State Derived from Mutagenic Scanning of the Pore Gating Energetics Biophysical Journal. 98: 697a. DOI: 10.1016/J.Bpj.2009.12.3825  0.687
2010 Piechotta PL, Stansfeld PJ, Bollepalli MK, Rapedius M, Andres-Enguix I, Shang L, Fritzenschaft H, Sansom MS, Tucker S, Baukrowitz T. TREK Channel Pore Probed by Cysteine Scanning Mutagenesis and Structural Modelling Biophysical Journal. 98: 327a. DOI: 10.1016/J.Bpj.2009.12.1773  0.75
2009 Rapedius M, Bollepalli MK, Tucker SJ, Baukrowitz T. State-dependent Cysteine Modification during pH and PIP2 Gating in Kir Channels Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.2379  0.654
2009 Bollepalli MK, Rapedius M, Fowler P, Xie M, Shang L, Fritzenschaft H, Sansom MS, Tucker SJ, Baukrowitz T. Gating Sensitive Residues In The Pore Of An Inwardly Rectifying Potassium (Kir) Channel Biophysical Journal. 96: 462a. DOI: 10.1016/J.Bpj.2008.12.2378  0.746
2008 Tucker SJ, Baukrowitz T. How highly charged anionic lipids bind and regulate ion channels. The Journal of General Physiology. 131: 431-8. PMID 18411329 DOI: 10.1085/Jgp.200709936  0.706
2007 Rapedius M, Paynter JJ, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing. Channels (Austin, Tex.). 1: 327-30. PMID 18690035 DOI: 10.4161/Chan.5176  0.72
2007 Rapedius M, Fowler PW, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. H bonding at the helix-bundle crossing controls gating in Kir potassium channels. Neuron. 55: 602-14. PMID 17698013 DOI: 10.1016/J.Neuron.2007.07.026  0.765
2006 Shumilina E, Klöcker N, Korniychuk G, Rapedius M, Lang F, Baukrowitz T. Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels. The Journal of Physiology. 575: 433-42. PMID 16777940 DOI: 10.1113/Jphysiol.2006.111161  0.586
2006 Rapedius M, Haider S, Browne KF, Shang L, Sansom MS, Baukrowitz T, Tucker SJ. Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel. Embo Reports. 7: 611-6. PMID 16641935 DOI: 10.1038/Sj.Embor.7400678  0.634
2005 Rapedius M, Soom M, Shumilina E, Schulze D, Schönherr R, Kirsch C, Lang F, Tucker SJ, Baukrowitz T. Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels. The Journal of Biological Chemistry. 280: 30760-7. PMID 15980413 DOI: 10.1074/Jbc.M503503200  0.711
2004 Kurata HT, Phillips LR, Rose T, Loussouarn G, Herlitze S, Fritzenschaft H, Enkvetchakul D, Nichols CG, Baukrowitz T. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis. The Journal of General Physiology. 124: 541-54. PMID 15477380 DOI: 10.1085/jgp.200409159  0.563
2004 Oliver D, Lien CC, Soom M, Baukrowitz T, Jonas P, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science (New York, N.Y.). 304: 265-70. PMID 15031437 DOI: 10.1126/Science.1094113  0.605
2000 Wissmann R, Baukrowitz T, Kalbacher H, Kalbitzer HR, Ruppersberg JP, Pongs O, Antz C, Fakler B. NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1. The Journal of Biological Chemistry. 274: 35521-5. PMID 10585425 DOI: 10.1074/jbc.274.50.35521  0.478
1999 Baukrowitz T, Tucker SJ, Schulte U, Benndorf K, Ruppersberg JP, Fakler B. Inward rectification in K(ATP) channels: A pH switch in the pore Embo Journal. 18: 847-853. PMID 10022827 DOI: 10.1093/Emboj/18.4.847  0.721
1998 Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B. PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science (New York, N.Y.). 282: 1141-4. PMID 9804555 DOI: 10.1126/Science.282.5391.1141  0.681
1994 Baukrowitz T, Hwang TC, Nairn AC, Gadsby DC. Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle. Neuron. 12: 473-82. PMID 7512348 DOI: 10.1016/0896-6273(94)90206-2  0.559
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