| Year |
Citation |
Score |
| 2022 |
Hwang TC, Braakman I, van der Sluijs P, Callebaut I. Structure basis of CFTR folding, function and pharmacology. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 36216744 DOI: 10.1016/j.jcf.2022.09.010 |
0.425 |
|
| 2022 |
Yeh HI, Sutcliffe KJ, Sheppard DN, Hwang TC. CFTR Modulators: From Mechanism to Targeted Therapeutics. Handbook of Experimental Pharmacology. PMID 35972584 DOI: 10.1007/164_2022_597 |
0.34 |
|
| 2022 |
Fang X, Yeh JT, Hwang TC. Pharmacological Responses of the G542X-CFTR to CFTR Modulators. Frontiers in Molecular Biosciences. 9: 921680. PMID 35813815 DOI: 10.3389/fmolb.2022.921680 |
0.36 |
|
| 2021 |
Yeh HI, Yu YC, Kuo PL, Tsai CK, Huang HT, Hwang TC. Functional stability of CFTR depends on tight binding of ATP at its degenerate ATP-binding site. The Journal of Physiology. PMID 34411298 DOI: 10.1113/JP281933 |
0.541 |
|
| 2019 |
de Wilde G, Gees M, Musch S, Verdonck K, Jans M, Wesse AS, Singh AK, Hwang TC, Christophe T, Pizzonero M, Van der Plas S, Desroy N, Cowart M, Stouten P, Nelles L, et al. Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators. Frontiers in Pharmacology. 10: 514. PMID 31143125 DOI: 10.3389/fphar.2019.00514 |
0.341 |
|
| 2018 |
Zhang J, Yu YC, Yeh JT, Hwang TC. Functional characterization reveals that zebrafish CFTR prefers to occupy closed channel conformations. Plos One. 13: e0209862. PMID 30596737 DOI: 10.1371/journal.pone.0209862 |
0.634 |
|
| 2018 |
Gees M, Musch S, Van der Plas S, Wesse AS, Vandevelde A, Verdonck K, Mammoliti O, Hwang TC, Sonck K, Stouten P, Swensen AM, Jans M, Van der Schueren J, Nelles L, Andrews M, et al. Identification and Characterization of Novel CFTR Potentiators. Frontiers in Pharmacology. 9: 1221. PMID 30416447 DOI: 10.3389/fphar.2018.01221 |
0.466 |
|
| 2018 |
Yeh JT, Yu YC, Hwang TC. Structural mechanisms for defective CFTR gating caused by the Q1412X mutation, a severe Class VI pathogenic mutation in cystic fibrosis. The Journal of Physiology. PMID 30408177 DOI: 10.1113/JP277042 |
0.363 |
|
| 2018 |
Hwang TC, Yeh JT, Zhang J, Yu YC, Yeh HI, Destefano S. Structural mechanisms of CFTR function and dysfunction. The Journal of General Physiology. PMID 29581173 DOI: 10.1085/jgp.201711946 |
0.46 |
|
| 2017 |
Martin SL, Saint-Criq V, Hwang TC, Csanády L. Ion channels as targets to treat cystic fibrosis lung disease. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 29102290 DOI: 10.1016/J.Jcf.2017.10.006 |
0.444 |
|
| 2017 |
Yeh HI, Sohma Y, Conrath K, Hwang TC. A common mechanism for CFTR potentiators. The Journal of General Physiology. PMID 29079713 DOI: 10.1085/jgp.201711886 |
0.573 |
|
| 2017 |
Jih KY, Lin WY, Sohma Y, Hwang TC. CFTR potentiators: from bench to bedside. Current Opinion in Pharmacology. 34: 98-104. PMID 29073476 DOI: 10.1016/j.coph.2017.09.015 |
0.485 |
|
| 2016 |
Lin WY, Sohma Y, Hwang TC. Synergistic Potentiation of CFTR gating by two chemically distinct potentiators, Ivacaftor (VX-770) and NPPB. Molecular Pharmacology. PMID 27413118 DOI: 10.1124/mol.116.104570 |
0.54 |
|
| 2016 |
Yu YC, Sohma Y, Hwang TC. On the mechanism of gating defects caused by the R117H mutation in CFTR. The Journal of Physiology. PMID 26846474 DOI: 10.1113/JP271723 |
0.468 |
|
| 2015 |
Zhang J, Hwang TC. The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane Conductance Regulator Contributes to Its Anion Permeation Pathway. Biochemistry. 54: 3839-50. PMID 26024338 DOI: 10.1021/acs.biochem.5b00427 |
0.37 |
|
| 2015 |
Gao X, Hwang TC. Localizing a gate in CFTR. Proceedings of the National Academy of Sciences of the United States of America. 112: 2461-6. PMID 25675504 DOI: 10.1073/pnas.1420676112 |
0.424 |
|
| 2015 |
Yeh HI, Yeh JT, Hwang TC. Modulation of CFTR gating by permeant ions. The Journal of General Physiology. 145: 47-60. PMID 25512598 DOI: 10.1085/jgp.201411272 |
0.561 |
|
| 2015 |
Kuo H, Hwang T. Role of Threonine 338 in CFTR Gating Biophysical Journal. 108: 584a. DOI: 10.1016/J.BPJ.2014.11.3186 |
0.353 |
|
| 2015 |
Lin WY, Jih K, Hwang T. VX-770 and NPPB Modulate CFTR Gating via Different but Dependent Mechanisms Biophysical Journal. 108: 583a. DOI: 10.1016/J.BPJ.2014.11.3183 |
0.313 |
|
| 2015 |
Yeh H, Yeh J, Hwang T. Potentiation of CFTR Gating by an Energetically Additive Mechanism Biophysical Journal. 108: 19a. DOI: 10.1016/J.BPJ.2014.11.130 |
0.363 |
|
| 2014 |
Lin WY, Jih KY, Hwang TC. A single amino acid substitution in CFTR converts ATP to an inhibitory ligand. The Journal of General Physiology. 144: 311-20. PMID 25225552 DOI: 10.1085/jgp.201411247 |
0.541 |
|
| 2013 |
Gao X, Bai Y, Hwang TC. Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation. Biophysical Journal. 104: 786-97. PMID 23442957 DOI: 10.1016/j.bpj.2012.12.048 |
0.379 |
|
| 2013 |
Jih KY, Hwang TC. Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proceedings of the National Academy of Sciences of the United States of America. 110: 4404-9. PMID 23440202 DOI: 10.1073/pnas.1215982110 |
0.573 |
|
| 2013 |
Hwang TC, Kirk KL. The CFTR ion channel: gating, regulation, and anion permeation. Cold Spring Harbor Perspectives in Medicine. 3: a009498. PMID 23284076 DOI: 10.1101/cshperspect.a009498 |
0.494 |
|
| 2013 |
Gao X, Hwang T. Probing the CFTR Chloride Channel with Channel Permeant Thio-Reactive Reagent Au(CN)2- Biophysical Journal. 104: 625a. DOI: 10.1016/J.BPJ.2012.11.3461 |
0.592 |
|
| 2012 |
Jih KY, Hwang TC. Nonequilibrium gating of CFTR on an equilibrium theme. Physiology (Bethesda, Md.). 27: 351-61. PMID 23223629 DOI: 10.1152/physiol.00026.2012 |
0.5 |
|
| 2012 |
Jih KY, Sohma Y, Hwang TC. Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation. The Journal of General Physiology. 140: 347-59. PMID 22966014 DOI: 10.1085/jgp.201210834 |
0.54 |
|
| 2012 |
Jih KY, Sohma Y, Li M, Hwang TC. Identification of a novel post-hydrolytic state in CFTR gating. The Journal of General Physiology. 139: 359-70. PMID 22508846 DOI: 10.1085/jgp.201210789 |
0.579 |
|
| 2012 |
Bai Y, Li M, Hwang TC. Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7). The Journal of General Physiology. 138: 495-507. PMID 22042986 DOI: 10.1085/jgp.201110705 |
0.54 |
|
| 2012 |
Nakamura Y, Hanyuda A, Yu Y, Hagiya-Furukawa T, Odera M, Hwang T, Sakurai M, Yasui M, Sohma Y. Effects of Genistein and Curcumin on Non ATP-Hydrolytic CFTR Mutants Biophysical Journal. 102: 548a. DOI: 10.1016/J.BPJ.2011.11.2990 |
0.301 |
|
| 2012 |
Jih K, Hwang T. On the Coupling Mechanism of CFTR Gating by ATP Hydrolysis Biophysical Journal. 102: 547a. DOI: 10.1016/J.BPJ.2011.11.2987 |
0.37 |
|
| 2012 |
Chen TY, Tsai MF, Hwang TC. Structures and mechanisms in chloride channels Comprehensive Biophysics. 6: 142-176. DOI: 10.1016/B978-0-12-374920-8.00619-6 |
0.663 |
|
| 2011 |
Cai Z, Sohma Y, Bompadre SG, Sheppard DN, Hwang TC. Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants. Methods in Molecular Biology (Clifton, N.J.). 741: 419-41. PMID 21594800 DOI: 10.1007/978-1-61779-117-8_27 |
0.59 |
|
| 2011 |
Jih KY, Li M, Hwang TC, Bompadre SG. The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR. The Journal of Physiology. 589: 2719-31. PMID 21486785 DOI: 10.1113/jphysiol.2010.202861 |
0.549 |
|
| 2011 |
Yu Y, Furukawa-Hagiya T, Yasui M, Hwang T, Sakurai M, Sohma Y. 3A0948 A STATE ESSENTIAL FOR PRIMING ATP-HYDROLYSIS IN GATING CYCLE IN AN ABC TRANSPORTER CFTR CHANNEL(3A Biol & Artifi memb 3: Excitation & Channels,The 49th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 51: S104. DOI: 10.2142/biophys.51.S104_4 |
0.493 |
|
| 2011 |
Bai Y, Li M, Hwang T. Helical Rotation Associated with the Gating of the CFTR Chloride Channel Biophysical Journal. 100: 264a. DOI: 10.1016/J.BPJ.2010.12.1654 |
0.568 |
|
| 2011 |
Sohma Y, Yu Y, Yasui M, Hwang T. A hidden Intermediate State for Priming ATP-Hydrolysis During Open Conformation in CFTR Channels Biophysical Journal. 100: 263a. DOI: 10.1016/J.BPJ.2010.12.1650 |
0.612 |
|
| 2010 |
Kopeikin Z, Sohma Y, Li M, Hwang TC. On the mechanism of CFTR inhibition by a thiazolidinone derivative. The Journal of General Physiology. 136: 659-71. PMID 21078867 DOI: 10.1085/jgp.201010518 |
0.652 |
|
| 2010 |
Tsai MF, Jih KY, Shimizu H, Li M, Hwang TC. Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels. The Journal of Biological Chemistry. 285: 37663-71. PMID 20861014 DOI: 10.1074/jbc.M110.172817 |
0.669 |
|
| 2010 |
Bai Y, Li M, Hwang TC. Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation. The Journal of General Physiology. 136: 293-309. PMID 20805575 DOI: 10.1085/jgp.201010480 |
0.521 |
|
| 2010 |
Shimizu H, Yu YC, Kono K, Kubota T, Yasui M, Li M, Hwang TC, Sohma Y. A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR. The Journal of Physiological Sciences : Jps. 60: 353-62. PMID 20628841 DOI: 10.1007/s12576-010-0102-2 |
0.525 |
|
| 2010 |
Tsai MF, Li M, Hwang TC. Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel. The Journal of General Physiology. 135: 399-414. PMID 20421370 DOI: 10.1085/jgp.201010399 |
0.678 |
|
| 2010 |
Miki H, Zhou Z, Li M, Hwang TC, Bompadre SG. Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs. The Journal of Biological Chemistry. 285: 19967-75. PMID 20406820 DOI: 10.1074/jbc.M109.092684 |
0.465 |
|
| 2010 |
Yu Y, Sohma Y, Hwang T, Yasui M. 3P238 Two possible mechanisms underlying a halt of NBD gating engine induced by instability of ATP binding in an ABC transporter CFTR(Biol & Artifi memb.: Excitation & Channels,The 48th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 50: S187. DOI: 10.2142/biophys.50.S187_2 |
0.473 |
|
| 2010 |
SOHMA Y, HWANG T. Mechanism of "NBD engine" in an ABC transporter, CFTR channel Seibutsu Butsuri. 50: 228-231. DOI: 10.2142/BIOPHYS.50.228 |
0.461 |
|
| 2010 |
Tsai M, Jih K, Li M, Hwang T. Optimization of the NBD1 Site Improves the Function of G551D-CFTR Channels Biophysical Journal. 98: 321a-322a. DOI: 10.1016/j.bpj.2009.12.1744 |
0.659 |
|
| 2010 |
Yu Y, Sohma Y, Nakamura Y, Furukawa T, Matsuzaki Y, Kawano S, Hwang T, Yasui M. Blocking Kinetics of CFTR Channel by Aromatic Carboxylic Acid Positional Isomers Characterised using a Novel Amplitude Distribution Analysis Method Biophysical Journal. 98: 321a. DOI: 10.1016/J.BPJ.2009.12.1742 |
0.418 |
|
| 2009 |
Tsai MF, Shimizu H, Sohma Y, Li M, Hwang TC. State-dependent modulation of CFTR gating by pyrophosphate. The Journal of General Physiology. 133: 405-19. PMID 19332621 DOI: 10.1085/jgp.200810186 |
0.698 |
|
| 2009 |
Hwang TC, Sheppard DN. Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation. The Journal of Physiology. 587: 2151-61. PMID 19332488 DOI: 10.1113/jphysiol.2009.171595 |
0.584 |
|
| 2009 |
Huang SY, Bolser D, Liu HY, Hwang TC, Zou X. Molecular modeling of the heterodimer of human CFTR's nucleotide-binding domains using a protein-protein docking approach. Journal of Molecular Graphics & Modelling. 27: 822-8. PMID 19167254 DOI: 10.1016/j.jmgm.2008.12.005 |
0.35 |
|
| 2009 |
Wang X, Bompadre SG, Li M, Hwang TC. Mutations at the signature sequence of CFTR create a Cd(2+)-gated chloride channel. The Journal of General Physiology. 133: 69-77. PMID 19114635 DOI: 10.1085/jgp.200810049 |
0.394 |
|
| 2009 |
Mio K, Ogura T, Mio M, Hwang T, Sohma Y, Sato C. 2TP5-03 Three-dimensional reconstruction of human CFTR chloride channel(The 47th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 49: S51. DOI: 10.2142/BIOPHYS.49.S51_1 |
0.411 |
|
| 2009 |
Mio K, Ogura T, Mio M, Hwang T, Sohma Y, Sato C. 2P-017 Three-dimensional reconstruction of human CFTR chloride channel(Protein:Structure,The 47th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 49: S109. DOI: 10.2142/BIOPHYS.49.S109_1 |
0.377 |
|
| 2009 |
Tsai M, Shimizu H, Soma Y, Li M, Hwang T. Two Distinct Gating Cycles of CFTR Chloride Channels Biophysical Journal. 96: 468a. DOI: 10.1016/J.BPJ.2008.12.2411 |
0.687 |
|
| 2009 |
Mio K, Ogura T, Mio M, Shimizu H, Hwang T, Sato C, Sohma Y. Three Dimensional Reconstruction of CFTR Chloride Channel Using Single Particle Analysis Biophysical Journal. 96: 468a. DOI: 10.1016/J.BPJ.2008.12.2408 |
0.422 |
|
| 2008 |
Mio K, Ogura T, Mio M, Shimizu H, Hwang TC, Sato C, Sohma Y. Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain. The Journal of Biological Chemistry. 283: 30300-10. PMID 18723516 DOI: 10.1074/jbc.M803185200 |
0.348 |
|
| 2008 |
Chen TY, Hwang TC. CLC-0 and CFTR: chloride channels evolved from transporters. Physiological Reviews. 88: 351-87. PMID 18391167 DOI: 10.1152/physrev.00058.2006 |
0.458 |
|
| 2008 |
Bompadre SG, Li M, Hwang TC. Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog. The Journal of Biological Chemistry. 283: 5364-9. PMID 18167357 DOI: 10.1074/jbc.M709417200 |
0.555 |
|
| 2007 |
Bompadre SG, Hwang TC. Cystic fibrosis transmembrane conductance regulator: a chloride channel gated by ATP binding and hydrolysis. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 59: 431-42. PMID 17700963 |
0.617 |
|
| 2007 |
Bompadre SG, Sohma Y, Li M, Hwang TC. G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects. The Journal of General Physiology. 129: 285-98. PMID 17353351 DOI: 10.1085/jgp.200609667 |
0.58 |
|
| 2006 |
Zhou Z, Wang X, Liu HY, Zou X, Li M, Hwang TC. The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics. The Journal of General Physiology. 128: 413-22. PMID 16966475 DOI: 10.1085/jgp.200609622 |
0.645 |
|
| 2006 |
Zhou Z, Hwang TC. Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Advances in Molecular and Cell Biology. 38: 145-180. DOI: 10.1016/S1569-2558(06)38006-X |
0.59 |
|
| 2005 |
Zhou Z, Wang X, Li M, Sohma Y, Zou X, Hwang TC. High affinity ATP/ADP analogues as new tools for studying CFTR gating. The Journal of Physiology. 569: 447-57. PMID 16223764 DOI: 10.1113/jphysiol.2005.095083 |
0.519 |
|
| 2005 |
Bompadre SG, Cho JH, Wang X, Zou X, Sohma Y, Li M, Hwang TC. CFTR gating II: Effects of nucleotide binding on the stability of open states. The Journal of General Physiology. 125: 377-94. PMID 15767296 DOI: 10.1085/jgp.200409228 |
0.594 |
|
| 2005 |
Bompadre SG, Ai T, Cho JH, Wang X, Sohma Y, Li M, Hwang TC. CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR). The Journal of General Physiology. 125: 361-75. PMID 15767295 DOI: 10.1085/jgp.200409227 |
0.663 |
|
| 2004 |
Sheppard DN, Gray MA, Gong X, Sohma Y, Kogan I, Benos DJ, Scott-Ward TS, Chen JH, Li H, Cai Z, Gupta J, Li C, Ramjeesingh M, Berdiev BK, Ismailov II, ... ... Hwang TC, et al. The patch-clamp and planar lipid bilayer techniques: powerful and versatile tools to investigate the CFTR Cl- channel. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 3: 101-8. PMID 15463939 DOI: 10.1016/J.Jcf.2004.05.046 |
0.43 |
|
| 2004 |
Ai T, Bompadre SG, Sohma Y, Wang X, Li M, Hwang TC. Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating. Pflugers Archiv : European Journal of Physiology. 449: 88-95. PMID 15290302 DOI: 10.1007/s00424-004-1317-y |
0.433 |
|
| 2004 |
Ai T, Bompadre SG, Wang X, Hu S, Li M, Hwang TC. Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents. Molecular Pharmacology. 65: 1415-26. PMID 15155835 DOI: 10.1124/mol.65.6.1415 |
0.558 |
|
| 2003 |
Hwang TC, Koeppe RE, Andersen OS. Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry. 42: 13646-58. PMID 14622011 DOI: 10.1021/Bi034887Y |
0.515 |
|
| 2002 |
Zhou Z, Hu S, Hwang TC. Probing an open CFTR pore with organic anion blockers. The Journal of General Physiology. 120: 647-62. PMID 12407077 DOI: 10.1085/jgp.20028685 |
0.541 |
|
| 2002 |
Powe A, Zhou Z, Hwang TC, Nagel G. Quantitative analysis of ATP-dependent gating of CFTR. Methods in Molecular Medicine. 70: 67-98. PMID 11917555 DOI: 10.1385/1-59259-187-6:67 |
0.428 |
|
| 2002 |
Powe AC, Al-Nakkash L, Li M, Hwang TC. Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains. The Journal of Physiology. 539: 333-46. PMID 11882668 DOI: 10.1113/Jphysiol.2001.013162 |
0.41 |
|
| 2001 |
Zou X, Hwang TC. ATP hydrolysis-coupled gating of CFTR chloride channels: structure and function. Biochemistry. 40: 5579-86. PMID 11341822 DOI: 10.1021/BI010133C |
0.602 |
|
| 2001 |
Zhou Z, Hu S, Hwang TC. Voltage-dependent flickery block of an open cystic fibrosis transmembrane conductance regulator (CFTR) channel pore. The Journal of Physiology. 532: 435-48. PMID 11306662 DOI: 10.1111/j.1469-7793.2001.0435f.x |
0.498 |
|
| 2000 |
Wang F, Zeltwanger S, Hu S, Hwang TC. Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels. The Journal of Physiology. 637-48. PMID 10790148 DOI: 10.1111/j.1469-7793.2000.00637.x |
0.625 |
|
| 1999 |
Hwang TC, Sheppard DN. Molecular pharmacology of the CFTR Cl- channel. Trends in Pharmacological Sciences. 20: 448-53. PMID 10542444 DOI: 10.1016/S0165-6147(99)01386-3 |
0.623 |
|
| 1999 |
Zeltwanger S, Wang F, Wang GT, Gillis KD, Hwang TC. Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis: Quantitative analysis of a cyclic gating scheme Journal of General Physiology. 113: 541-554. PMID 10102935 DOI: 10.1085/jgp.113.4.541 |
0.637 |
|
| 1999 |
Al-Nakkash L, Hwang TC. Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms. Pflugers Archiv : European Journal of Physiology. 437: 553-61. PMID 10089568 DOI: 10.1007/s004240050817 |
0.384 |
|
| 1998 |
Wang F, Zeltwanger S, Yang IC, Nairn AC, Hwang TC. Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects. The Journal of General Physiology. 111: 477-90. PMID 9482713 DOI: 10.1085/jgp.111.3.477 |
0.554 |
|
| 1997 |
Hwang TC, Wang F, Yang IC, Reenstra WW. Genistein potentiates wild-type and delta F508-CFTR channel activity. The American Journal of Physiology. 273: C988-98. PMID 9316420 DOI: 10.1152/AJPCELL.1997.273.3.C988 |
0.376 |
|
| 1997 |
Yang IC, Cheng TH, Wang F, Price EM, Hwang TC. Modulation of CFTR chloride channels by calyculin A and genistein. The American Journal of Physiology. 272: C142-55. PMID 9038820 DOI: 10.1152/ajpcell.1997.272.1.C142 |
0.459 |
|
| 1995 |
Gadsby DC, Nagel G, Hwang TC. The CFTR chloride channel of mammalian heart Annual Review of Physiology. 57: 387-416. PMID 7539989 DOI: 10.1146/Annurev.Ph.57.030195.002131 |
0.385 |
|
| 1994 |
Franks-Skiba K, Hwang T, Cooke R. Quenching of fluorescent nucleotides bound to myosin: a probe of the active-site conformation. Biochemistry. 33: 12720-8. PMID 7918498 DOI: 10.1021/BI00208A025 |
0.309 |
|
| 1994 |
Hwang TC, Nagel G, Nairn AC, Gadsby DC. Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 91: 4698-702. PMID 7515176 DOI: 10.1073/Pnas.91.11.4698 |
0.644 |
|
| 1994 |
Baukrowitz T, Hwang TC, Nairn AC, Gadsby DC. Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle. Neuron. 12: 473-82. PMID 7512348 DOI: 10.1016/0896-6273(94)90206-2 |
0.655 |
|
| 1994 |
Hwang TC, Gadsby DC. Chloride ion channels in mammalian heart cells Current Topics in Membranes. 42: 317-346. DOI: 10.1016/S0070-2161(08)60826-6 |
0.461 |
|
| 1993 |
Gadsby DC, Hwang TC, Horie M, Nagel G, Nairn AC. Cardiac chloride channels: incremental regulation by phosphorylation/dephosphorylation. Annals of the New York Academy of Sciences. 707: 259-74. PMID 9137557 DOI: 10.1111/J.1749-6632.1993.Tb38057.X |
0.464 |
|
| 1992 |
Nagel G, Hwang TC, Nastiuk KL, Nairn AC, Gadsby DC. The protein kinase A-regulated cardiac Cl- channel resembles the cystic fibrosis transmembrane conductance regulator. Nature. 360: 81-4. PMID 1279437 DOI: 10.1038/360081A0 |
0.565 |
|
| 1992 |
Hwang TC, Egan ME, Guggino WB. Kinetic interaction of fatty acids with outwardly rectifying chloride channels Cellular Physiology and Biochemistry. 2: 308-315. DOI: 10.1159/000154653 |
0.491 |
|
| 1989 |
Hwang TC, Lu L, Zeitlin PL, Gruenert DC, Huganir R, Guggino WB. C1- channels in CF: Lack of activation by protein kinase C and cAMP-dependent protein kinase Science. 244: 1351-1353. PMID 2472005 DOI: 10.1126/Science.2472005 |
0.41 |
|
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