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David A. Nielsen, Ph.D. - Publications

1972-1976 Biochemistry University of Wisconsin, Madison, Madison, WI 
 1979-1984 Biochemistry and Molecular Biology University of Chicago, Chicago, IL 
 1984-1990 Biochemistry University of Illinois at Urbana 
 1990-1999 Laboratory of Human Genetics NIAAA/NIH, Bethesda, MD, United States 
 1990-2002 InforMax, Inc 
 2002-2008 Kreek Laboratory Rockefeller University, New York, NY, United States 
 2008- Baylor College of Medicine, Houston, TX 
Psychiatric Genetics

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Year Citation  Score
2019 Kampangkaew JP, Spellicy CJ, Nielsen EM, Harding MJ, Ye A, Hamon SC, Kosten TR, Nielsen DA. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction. The American Journal On Addictions. PMID 31087723 DOI: 10.1111/ajad.12891  1
2019 Deng H, Desai PV, Mohite S, Okusaga OO, Zhang XY, Nielsen DA, Kosten TR. Hospital Stay in Synthetic Cannabinoid Users With Bipolar Disorder, Schizophrenia, or Other Psychotic Disorders Compared With Cannabis Users. Journal of Studies On Alcohol and Drugs. 80: 230-235. PMID 31014468  1
2019 Nielsen DA, Deng H, Patriquin MA, Harding MJ, Oldham J, Salas R, Fowler JC, Frueh BC. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European Archives of Psychiatry and Clinical Neuroscience. PMID 30923939 DOI: 10.1007/s00406-019-01009-w  1
2018 Patel MM, Nielsen DA, Kosten TR, De La Garza R, Newton TF, Verrico CD. FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration. The American Journal On Addictions. PMID 30126012 DOI: 10.1111/ajad.12788  1
2018 Deng H, Verrico CD, Kosten TR, Nielsen DA. Psychosis and synthetic cannabinoids. Psychiatry Research. 268: 400-412. PMID 30125871 DOI: 10.1016/j.psychres.2018.08.012  1
2018 Nielsen DA, Spellicy CJ, Harding MJ, Graham DP. Apolipoprotein E DNA Methylation and Posttraumatic Stress Disorder are Associated with Plasma ApoE Level: A Preliminary Study. Behavioural Brain Research. PMID 29807071 DOI: 10.1016/j.bbr.2018.05.013  1
2018 Kosten TR, Graham DP, Nielsen DA. Opioid Use Disorder After Self-medicating Pain From Traumatic Brain Injury. Jama Psychiatry. PMID 29710138 DOI: 10.1001/jamapsychiatry.2018.0098  1
2018 Kosten TR, Graham DP, Nielsen DA. Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. Jama Psychiatry. PMID 29710079 DOI: 10.1001/jamapsychiatry.2018.0101  1
2018 Zhang X, Nielsen DA, Domingo CB, Shorter DI, Nielsen EM, Kosten TR. Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin. Addiction Biology. PMID 29498170 DOI: 10.1111/adb.12611  1
2018 Deng H, Mohite S, Suchting R, Nielsen DA, Okusaga OO. Impact of synthetic cannabinoid use on hospital stay in patients with bipolar disorder versus schizophrenia, or other psychotic disorders. Psychiatry Research. 261: 248-252. PMID 29329043 DOI: 10.1016/j.psychres.2017.12.089  1
2017 Curtis K, Viswanath H, Velasquez KM, Molfese DL, Harding MJ, Aramayo E, Baldwin PR, Ambrosi E, Madan A, Patriquin M, Frueh BC, Fowler JC, Kosten TR, Nielsen DA, Salas R. Increased habenular connectivity in opioid users is associated with an α5 subunit nicotinic receptor genetic variant. The American Journal On Addictions. PMID 28857330 DOI: 10.1111/ajad.12607  1
2017 Patriquin MA, Hamon SC, Harding MJ, Nielsen EM, Newton TF, De La Garza R, Nielsen DA. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric Genetics. PMID 28590957 DOI: 10.1097/YPG.0000000000000178  1
2016 Wachman EM, Hayes MJ, Sherva R, Brown MS, Shrestha H, Logan BA, Heller NA, Nielsen DA, Farrer LA. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. The American Journal On Addictions. PMID 27983768 DOI: 10.1111/ajad.12483  1
2016 Shorter D, Nielsen DA, Hamon SC, Nielsen EM, Kosten TR, Newton TF, De La Garza R. The α-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals. Pharmacogenetics and Genomics. PMID 27379509 DOI: 10.1097/FPC.0000000000000234  1
2016 Nieto SJ, Patriquin MA, Nielsen DA, Kosten TA. Don't worry; be informed about the epigenetics of anxiety. Pharmacology, Biochemistry, and Behavior. PMID 27189589 DOI: 10.1016/j.pbb.2016.05.006  1
2016 Cao B, Bauer IE, Sharma AN, Mwangi B, Frazier T, Lavagnino L, Zunta-Soares GB, Walss-Bass C, Glahn DC, Kapczinski F, Nielsen DA, Soares JC. Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. Journal of Affective Disorders. 198: 198-205. PMID 27018938 DOI: 10.1016/j.jad.2016.03.044  1
2015 Azadeh S, Hobbs BP, Ma L, Nielsen DA, Moeller FG, Baladandayuthapani V. Integrative Bayesian Analysis of Neuroimaging-Genetic Data with Application to Cocaine Dependence. Neuroimage. PMID 26484829 DOI: 10.1016/j.neuroimage.2015.10.033  1
2015 Bauer IE, Graham DP, Soares JC, Nielsen DA. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. 1-8. PMID 26265436 DOI: 10.2217/pgs.15.72  1
2015 Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Variations in opioid receptor genes in neonatal abstinence syndrome. Drug and Alcohol Dependence. PMID 26233486 DOI: 10.1016/j.drugalcdep.2015.07.001  1
2015 Patriquin MA, Bauer IE, Soares JC, Graham DP, Nielsen DA. Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system. Psychiatric Genetics. PMID 26146874 DOI: 10.1097/YPG.0000000000000095  1
2015 Liu S, Maili L, Lane SD, Schmitz JM, Spellicy CJ, Cunningham KA, Moeller FG, Nielsen DA. Serotonin transporter gene promoter polymorphism predicts relationship between years of cocaine use and impulsivity. Psychiatric Genetics. PMID 26110342 DOI: 10.1097/YPG.0000000000000094  1
2015 Brewer AJ, Nielsen DA, Spellicy CJ, Hamon SC, Gingrich J, Thompson-Lake DG, Nielsen EM, Mahoney JJ, Kosten TR, Newton TF, De La Garza R. Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders. Pharmacogenetics and Genomics. 25: 296-304. PMID 25850966 DOI: 10.1097/FPC.0000000000000137  1
2015 Bauer IE, Soares JC, Nielsen DA. The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. 24: 15-23. PMID 25823631 DOI: 10.1111/ajad.12172  1
2015 Wachman EM, Hayes MJ, Sherva R, Brown MS, Davis JM, Farrer LA, Nielsen DA. Variations in opioid receptor genes in neonatal abstinence syndrome Drug and Alcohol Dependence. DOI: 10.1016/j.drugalcdep.2015.07.001  1
2014 Bauer IE, Soares JC, Nielsen DA. The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. The American Journal On Addictions / American Academy of Psychiatrists in Alcoholism and Addictions. PMID 25418439 DOI: 10.1111/j.1521-0391.2014.12172.x  1
2014 Nielsen DA, Nielsen EM, Dasari T, Spellicy CJ. Pharmacogenetics of addiction therapy. Methods in Molecular Biology (Clifton, N.J.). 1175: 589-624. PMID 25150877 DOI: 10.1007/978-1-4939-0956-8_15  1
2014 Wachman EM, Hayes MJ, Lester BM, Terrin N, Brown MS, Nielsen DA, Davis JM. Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. The Journal of Pediatrics. 165: 472-8. PMID 24996986 DOI: 10.1016/j.jpeds.2014.05.040  1
2014 Graham DP, Nielsen DA, Kosten TR, Davis LL, Hamner MB, Makotkine I, Yehuda R. Examining the utility of using genotype and functional biology in a clinical pharmacology trial: pilot testing dopamine β-hydroxylase, norepinephrine, and post-traumatic stress disorder. Psychiatric Genetics. 24: 181-2. PMID 24983834 DOI: 10.1097/YPG.0000000000000039  1
2014 Frazier TW, Youngstrom EA, Frankel BA, Zunta-Soares GB, Sanches M, Escamilla M, Nielsen DA, Soares JC. Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes. Brain and Behavior. 4: 418-30. PMID 24944871 DOI: 10.1002/brb3.226  1
2014 Liu S, Green CE, Lane SD, Kosten TR, Moeller FG, Nielsen DA, Schmitz JM. The influence of dopamine β-hydroxylase gene polymorphism rs1611115 on levodopa/carbidopa treatment for cocaine dependence: a preliminary study. Pharmacogenetics and Genomics. 24: 370-3. PMID 24809448 DOI: 10.1097/FPC.0000000000000055  1
2014 Kosten TA, Nielsen DA. Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 36: 5-12. PMID 24721039 DOI: 10.1016/j.ijdevneu.2014.03.010  1
2014 Anastasio NC, Liu S, Maili L, Swinford SE, Lane SD, Fox RG, Hamon SC, Nielsen DA, Cunningham KA, Moeller FG. Variation within the serotonin (5-HT) 5-HT₂C receptor system aligns with vulnerability to cocaine cue reactivity. Translational Psychiatry. 4: e369. PMID 24618688 DOI: 10.1038/tp.2013.131  1
2014 Spellicy CJ, Harding MJ, Hamon SC, Mahoney JJ, Reyes JA, Kosten TR, Newton TF, De La Garza R, Nielsen DA. A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. Genes, Brain, and Behavior. 13: 559-64. PMID 24528631 DOI: 10.1111/gbb.12121  1
2014 Kosten TA, Huang W, Nielsen DA. Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats. Developmental Psychobiology. 56: 392-406. PMID 23460384 DOI: 10.1002/dev.21106  1
2014 Kosten TA, Nielsen DA. Maternal Epigenetic Inheritance and Stress During Gestation. Focus on Brain and Behavioral Disorders. Transgenerational Epigenetics. 197-219. DOI: 10.1016/B978-0-12-405944-3.00016-7  1
2013 Nielsen DA, Hamon SC, Kosten TR. The κ-opioid receptor gene as a predictor of response in a cocaine vaccine clinical trial. Psychiatric Genetics. 23: 225-32. PMID 23995774 DOI: 10.1097/YPG.0000000000000008  1
2013 Shorter D, Nielsen DA, Huang W, Harding MJ, Hamon SC, Kosten TR. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 1401-7. PMID 23849431 DOI: 10.1016/j.euroneuro.2013.05.014  1
2013 Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Pharmacogenetics and Genomics. 23: 333-40. PMID 23635803 DOI: 10.1097/FPC.0b013e328361c39d  1
2013 Graham DP, Helmer DA, Harding MJ, Kosten TR, Petersen NJ, Nielsen DA. Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans. Journal of Psychiatric Research. 47: 835-42. PMID 23478049 DOI: 10.1016/j.jpsychires.2013.02.006  1
2013 Kosten TR, Domingo CB, Hamon SC, Nielsen DA. DBH gene as predictor of response in a cocaine vaccine clinical trial. Neuroscience Letters. 541: 29-33. PMID 23458673 DOI: 10.1016/j.neulet.2013.02.037  1
2013 Kosten TR, Wu G, Huang W, Harding MJ, Hamon SC, Lappalainen J, Nielsen DA. Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase. Biological Psychiatry. 73: 219-24. PMID 22906516 DOI: 10.1016/j.biopsych.2012.07.011  1
2012 Spellicy CJ, Kosten TR, Hamon SC, Harding MJ, Nielsen DA. The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. Frontiers in Psychiatry. 3: 109. PMID 23335901 DOI: 10.3389/fpsyt.2012.00109  1
2012 Haile CN, De La Garza R, Mahoney JJ, Nielsen DA, Kosten TR, Newton TF. The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial. Plos One. 7: e47702. PMID 23144826 DOI: 10.1371/journal.pone.0047702  1
2012 Nielsen DA, Harding MJ, Hamon SC, Huang W, Kosten TR. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Genes, Brain, and Behavior. 11: 1001-8. PMID 22925276 DOI: 10.1111/j.1601-183X.2012.00839.x  1
2012 Nielsen DA, Utrankar A, Reyes JA, Simons DD, Kosten TR. Epigenetics of drug abuse: predisposition or response. Pharmacogenomics. 13: 1149-60. PMID 22909205 DOI: 10.2217/pgs.12.94  1
2012 Nielsen DA, Huang W, Hamon SC, Maili L, Witkin BM, Fox RG, Cunningham KA, Moeller FG. Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. Frontiers in Psychiatry. 3: 60. PMID 22712019 DOI: 10.3389/fpsyt.2012.00060  1
2012 Nielsen DA, Kreek MJ. Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug and Alcohol Dependence. 123: S33-41. PMID 22542464 DOI: 10.1016/j.drugalcdep.2012.03.026  1
2012 Nielsen DA, Ho A, Bahl A, Varma P, Kellogg S, Borg L, Kreek MJ. Former heroin addicts with or without a history of cocaine dependence are more impulsive than controls. Drug and Alcohol Dependence. 124: 113-20. PMID 22265192 DOI: 10.1016/j.drugalcdep.2011.12.022  1
2012 Nielsen DA, Proudnikov D, Kreek MJ. The Genetics of Impulsivity The Oxford Handbook of Impulse Control Disorders. DOI: 10.1093/oxfordhb/9780195389715.013.0080  1
2011 Hao Y, Huang W, Nielsen DA, Kosten TA. Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Frontiers in Psychiatry. 2: 21. PMID 21629839 DOI: 10.3389/fpsyt.2011.00021  1
2011 Yuferov V, Nielsen DA, Levran O, Randesi M, Hamon S, Ho A, Morgello S, Kreek MJ. Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs. Pharmacogenetics and Genomics. 21: 185-96. PMID 20808262 DOI: 10.1097/FPC.0b013e32833eecbc  1
2011 Rouault M, Nielsen DA, Ho A, Kreek MJ, Yuferov V. Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity. Addiction Biology. 16: 334-46. PMID 20731629 DOI: 10.1111/j.1369-1600.2010.00248.x  1
2010 Nielsen DA, Ji F, Yuferov V, Ho A, He C, Ott J, Kreek MJ. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. Psychiatric Genetics. 20: 207-14. PMID 20520587 DOI: 10.1097/YPG.0b013e32833a2106  1
2010 Nielsen DA, Hamon S, Yuferov V, Jackson C, Ho A, Ott J, Kreek MJ. Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Human Genetics. 127: 639-49. PMID 20237803 DOI: 10.1007/s00439-010-0807-6  1
2010 Yuferov V, Levran O, Proudnikov D, Nielsen DA, Kreek MJ. Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Annals of the New York Academy of Sciences. 1187: 184-207. PMID 20201854 DOI: 10.1111/j.1749-6632.2009.05275.x  1
2010 Briant JA, Nielsen DA, Proudnikov D, Londono D, Ho A, Ott J, Kreek MJ. Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Psychiatric Genetics. 20: 65-72. PMID 20032820 DOI: 10.1097/YPG.0b013e32833511f6  1
2009 Yuferov V, Ji F, Nielsen DA, Levran O, Ho A, Morgello S, Shi R, Ott J, Kreek MJ. A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1185-97. PMID 18923396 DOI: 10.1038/npp.2008.187  1
2009 Kreek MJ, Schlussman SD, Reed B, Zhang Y, Nielsen DA, Levran O, Zhou Y, Butelman ER. Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology. 56: 32-43. PMID 18725235 DOI: 10.1016/j.neuropharm.2008.07.042  1
2009 Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 867-73. PMID 18650805 DOI: 10.1038/npp.2008.108  1
2009 Nielsen DA, Yuferov V, Hamon S, Jackson C, Ho A, Ott J, Kreek MJ. Increased OPRM1 DNA methylation in lymphocytes of methadone (Neuropsychopharmacology (2008) DOI: 10.1038/npp.2008.108) Neuropsychopharmacology. 34: 1087. DOI: 10.1038/npp.2008.155  1
2008 Levran O, Londono D, O'Hara K, Nielsen DA, Peles E, Rotrosen J, Casadonte P, Linzy S, Randesi M, Ott J, Adelson M, Kreek MJ. Genetic susceptibility to heroin addiction: a candidate gene association study. Genes, Brain, and Behavior. 7: 720-9. PMID 18518925 DOI: 10.1111/j.1601-183X.2008.00410.x  1
2008 Oosterhuis BE, LaForge KS, Proudnikov D, Ho A, Nielsen DA, Gianotti R, Barral S, Gordon D, Leal SM, Ott J, Kreek MJ. Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 793-8. PMID 18270997 DOI: 10.1002/ajmg.b.30716  1
2008 Nielsen DA, Ji F, Yuferov V, Ho A, Chen A, Levran O, Ott J, Kreek MJ. Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Molecular Psychiatry. 13: 417-28. PMID 18195715 DOI: 10.1038/  1
2008 Nielsen DA, Barral S, Proudnikov D, Kellogg S, Ho A, Ott J, Kreek MJ. TPH2 and TPH1: association of variants and interactions with heroin addiction. Behavior Genetics. 38: 133-50. PMID 18181017 DOI: 10.1007/s10519-007-9187-7  1
2007 Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. Journal of Neurochemistry. 103: 77-87. PMID 17877633 DOI: 10.1111/j.1471-4159.2007.04738.x  1
2007 Nielsen DA, Leidner M, Haynes C, Krauthammer M, Kreek MJ. The BiolAD-DB system : an informatics system for clinical and genetic data. Molecular Diagnosis & Therapy. 11: 15-9. PMID 17286447  1
2005 Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience. 8: 1450-7. PMID 16251987 DOI: 10.1038/nn1583  1
2005 Yuferov V, Nielsen D, Butelman E, Kreek MJ. Microarray studies of psychostimulant-induced changes in gene expression. Addiction Biology. 10: 101-18. PMID 15849024 DOI: 10.1080/13556210412331308976  1
2005 Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacological Reviews. 57: 1-26. PMID 15734726 DOI: 10.1124/pr.57.1.1  1
2004 Yuferov V, Fussell D, LaForge KS, Nielsen DA, Gordon D, Ho A, Leal SM, Ott J, Kreek MJ. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics. 14: 793-804. PMID 15608558 DOI: 10.1097/00008571-200412000-00002  1
2004 Kreek MJ, Nielsen DA, LaForge KS. Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Medicine. 5: 85-108. PMID 15001815 DOI: 10.1385/NMM:5:1:085  1
2001 Roy A, Rylander G, Forslund K, Asberg M, Mazzanti CM, Goldman D, Nielsen DA. Excess tryptophan hydroxylase 17 779C allele in surviving cotwins of monozygotic twin suicide victims. Neuropsychobiology. 43: 233-6. PMID 11340361 DOI: 10.1159/000054895  1
1999 Nielsen DA, Mazzanti CM, Linnoila M, Goldman D. Serotonin transporter and seasonal variation in serotonin function (2) Neuropsychopharmacology. 20: 507-508. PMID 26468552 DOI: 10.1016/S0893-133X(98)00073-6  1
1999 Rotondo A, Schuebel KE, Bergen AW, Aragon R, Virkkunen M, Linnoila M, Goldman D, Nielsen DA. Identification of four variants in the tryptophan hydroxylase promoter and association to behavior Molecular Psychiatry. 4: 360-368. PMID 10483053  1
1999 Han L, Nielsen DA, Rosenthal NE, Jefferson K, Kaye W, Murphy D, Altemus M, Humphries J, Cassano G, Rotondo A, Virkkunen M, Linnoila M, Goldman D. No coding variant of the tryptophan hydroxylase gene detected in seasonal affective disorder, obsessive-compulsive disorder, anorexia nervosa, and alcoholism. Biological Psychiatry. 45: 615-9. PMID 10088048 DOI: 10.1016/S0006-3223(98)00122-X  1
1998 Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Archives of General Psychiatry. 55: 593-602. PMID 9672049 DOI: 10.1001/archpsyc.55.7.593  1
1998 New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ. Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. American Journal of Medical Genetics. 81: 13-7. PMID 9514581 DOI: 10.1002/(SICI)1096-8628(19980207)81:1<13::AID-AJMG3>3.0.CO;2-O  1
1997 Jönsson EG, Goldman D, Spurlock G, Gustavsson JP, Nielsen DA, Linnoila M, Owen MJ, Sedvall GC. Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. European Archives of Psychiatry and Clinical Neuroscience. 247: 297-302. PMID 9477008  1
1997 Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. The American Journal of Psychiatry. 154: 1451-3. PMID 9326831  1
1997 Rotondo A, Nielsen DA, Nakhai B, Hulihan-Giblin B, Bolos A, Goldman D. Agonist-promoted down-regulation and functional desensitization in two naturally occurring variants of the human serotonin1A receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 17: 18-26. PMID 9194046 DOI: 10.1016/S0893-133X(97)00021-3  1
1997 Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D. Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Brain Research. Molecular Brain Research. 45: 145-8. PMID 9105682 DOI: 10.1016/S0169-328X(96)00304-X  1
1996 Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. TPH replication study: not! Archives of General Psychiatry. 53: 964-5. PMID 8857875  1
1996 Henley WN, Schuebel KE, Nielsen DA. Limitations imposed by heteroduplex formation on quantitative RT-PCR. Biochemical and Biophysical Research Communications. 226: 113-7. PMID 8806600 DOI: 10.1006/bbrc.1996.1319  1
1996 Schuebel KE, Bustelo XR, Nielsen DA, Song BJ, Barbacid M, Goldman D, Lee IJ. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene. 13: 363-71. PMID 8710375  1
1995 McCarthy MM, Nielsen DA, Goldman D. Antisense oligonucleotide inhibition of tryptophan hydroxylase activity in mouse brain. Regulatory Peptides. 59: 163-70. PMID 8584751 DOI: 10.1016/0167-0115(95)00102-H  1
1995 Nakhai B, Nielsen DA, Linnoila M, Goldman D. Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochemical and Biophysical Research Communications. 210: 530-6. PMID 7755630 DOI: 10.1006/bbrc.1995.1692  1
1995 Nielsen DA, Novoradovsky A, Goldman D. SSCP primer design based on single-strand DNA structure predicted by a DNA folding program. Nucleic Acids Research. 23: 2287-91. PMID 7610057 DOI: 10.1093/nar/23.12.2287  1
1995 Virkkunen M, Goldman D, Nielsen DA, Linnoila M. Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence. Journal of Psychiatry & Neuroscience : Jpn. 20: 271-5. PMID 7544158  1
1994 Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Archives of General Psychiatry. 51: 34-8. PMID 7506517 DOI: 10.1001/archpsyc.1994.03950010034005  1
1992 Nielsen DA, Dean M, Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. American Journal of Human Genetics. 51: 1366-71. PMID 1463016  1
1990 Nielsen DA, Shapiro DJ. Estradiol and estrogen receptor-dependent stabilization of a minivitellogenin mRNA lacking 5,100 nucleotides of coding sequence. Molecular and Cellular Biology. 10: 371-6. PMID 2294409  1
1990 Nielsen DA, Shapiro DJ. Insights into hormonal control of messenger RNA stability. Molecular Endocrinology (Baltimore, Md.). 4: 953-7. PMID 2284008 DOI: 10.1210/mend-4-7-953  1
1989 Nielsen DA, Chang TC, Shapiro DJ. A highly sensitive, mixed-phase assay for chloramphenicol acetyltransferase activity in transfected cells. Analytical Biochemistry. 179: 19-23. PMID 2757194 DOI: 10.1016/0003-2697(89)90193-0  1
1989 Shapiro DJ, Barton MC, McKearin DM, Chang TC, Lew D, Blume J, Nielsen DA, Gould L. Estrogen regulation of gene transcription and mRNA stability. Recent Progress in Hormone Research. 45: 29-58; discussion 58. PMID 2682843  1
1988 Welsh M, Weber T, Wrange O, Nielsen DA, Matthieu M, Steiner DF. Regulation of insulin gene expression by dexamethasone, Ca2+ and a phorbol ester. Biomedica Biochimica Acta. 47: 299-303. PMID 3071361  1
1987 Shapiro DJ, Blume JE, Nielsen DA. Regulation of messenger RNA stability in eukaryotic cells. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 6: 221-6. PMID 3606588 DOI: 10.1002/bies.950060507  1
1986 Nielsen DA, Shapiro DJ. Preparation of capped RNA transcripts using T7 RNA polymerase. Nucleic Acids Research. 14: 5936. PMID 3526287 DOI: 10.1093/nar/14.14.5936  1
1985 Welsh M, Nielsen DA, MacKrell AJ, Steiner DF. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability. The Journal of Biological Chemistry. 260: 13590-4. PMID 3902821  1
1985 Nielsen DA, Welsh M, Casadaban MJ, Steiner DF. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA. The Journal of Biological Chemistry. 260: 13585-9. PMID 2997172  1
1983 Nielsen DA, Chou J, MacKrell AJ, Casadaban MJ, Steiner DF. Expression of a preproinsulin-beta-galactosidase gene fusion in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 5198-202. PMID 6310564  1
1982 Nielsen DA, Lernmark A, Berelowitz M, Bloom GD, Steiner DF. Sorting of pancreatic islet cell subpopulations by light scattering using a fluorescence-activated cell sorter. Diabetes. 31: 299-306. PMID 6130019  1
1981 Lernmark A, Nielsen DA, Nielsen O, Larsen JK. Light scattering analysis of rat and mouse islet cells in the fluorescence-activated cell sorter. Upsala Journal of Medical Sciences. 86: 119-24. PMID 7034342 DOI: 10.3109/03009738109179218  1
1981 Baekkeskov S, Kanatsuna T, Klareskog L, Nielsen DA, Peterson PA, Rubenstein AH, Steiner DF, Lernmark A. Expression of major histocompatibility antigens on pancreatic islet cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 6456-60. PMID 7031653  1
1980 Lernmark A, Nielsen DA, Parman AU, Sehlin J, Steiner DF, Täljedal IB. Cation-activated phosphatase activities in islet cell plasma membrane preparations. Hormone and Metabolic Research. Supplement Series. 55-61. PMID 6256271  1
1978 Lernmark A, Nielsen DA, Steiner DF. Cation-dependent phosphatase activites in a rat pancreatic islet plasma membrane fraction prepared by one-step gradient centrifugation. Journal of Supramolecular Structure. 9: 327-36. PMID 34753 DOI: 10.1002/jss.400090304  1
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