Paul A. Insel - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Pharmacology
Website:
http://www-insel.ucsd.edu/

241 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Frontiers in Pharmacology. 9: 431. PMID 29872392 DOI: 10.3389/fphar.2018.00431  1
2017 Busija AR, Patel HH, Insel PA. Hugh Davson Distinguished Lectureship Article Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. American Journal of Physiology. Cell Physiology. ajpcell.00355.2016. PMID 28122734 DOI: 10.1152/ajpcell.00355.2016  0.96
2015 Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proceedings of the National Academy of Sciences of the United States of America. PMID 26417071 DOI: 10.1073/pnas.1516057112  1
2015 Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. The Journal of Biological Chemistry. 290: 22274-86. PMID 26203188 DOI: 10.1074/jbc.M115.658153  1
2015 Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Molecular Pharmacology. 88: 139-40. PMID 25943115 DOI: 10.1124/mol.115.099564  1
2015 Overland AC, Insel PA. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. The Journal of Biological Chemistry. 290: 9941-7. PMID 25759388 DOI: 10.1074/jbc.C115.647073  1
2015 Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, et al. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Molecular Pharmacology. 88: 181-7. PMID 25737495 DOI: 10.1124/mol.115.098129  1
2015 Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 112: 1529-34. PMID 25605931 DOI: 10.1073/pnas.1417972112  1
2015 Insel PA, Amara SG, Blaschke TF. Introduction to the theme "Precision medicine and prediction in pharmacology". Annual Review of Pharmacology and Toxicology. 55: 11-4. PMID 25562643 DOI: 10.1146/annurev-pharmtox-101714-123102  1
2014 Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel PA. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. The Journal of Biological Chemistry. 289: 29148-57. PMID 25183009 DOI: 10.1074/jbc.M114.569319  0.68
2014 Insel PA, Wilderman A, Zhang L, Keshwani MM, Zambon AC. Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et MéTabolisme. 46: 854-62. PMID 25028794 DOI: 10.1055/s-0034-1384519  1
2014 Foufelle F, Lotersztajn S, Insel PA, Chevet E. AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. American Journal of Physiology. Cell Physiology. 307: C581. PMID 24990648 DOI: 10.1152/ajpcell.00221.2014  1
2014 Fridolfsson HN, Roth DM, Insel PA, Patel HH. Regulation of intracellular signaling and function by caveolin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3823-3831. PMID 24858278 DOI: 10.1096/fj.14-252320  1
2014 Lu D, Insel PA. Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. American Journal of Physiology. Cell Physiology. 306: C779-88. PMID 24352335 DOI: 10.1152/ajpcell.00381.2013  1
2014 Fuller CM, Insel PA. I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?". American Journal of Physiology. Cell Physiology. 306: C1-2. PMID 24225885 DOI: 10.1152/ajpcell.00342.2013  1
2014 McCarty OJ, King MR, Insel PA. A theme series on physical biology in cancer in AJP-Cell. American Journal of Physiology. Cell Physiology. 306: C77. PMID 24067917 DOI: 10.1152/ajpcell.00295.2013  1
2014 Head BP, Patel HH, Insel PA. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochimica Et Biophysica Acta. 1838: 532-45. PMID 23899502 DOI: 10.1016/j.bbamem.2013.07.018  1
2013 Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Molecular Pharmacology. 84: 787-93. PMID 24085841 DOI: 10.1124/mol.113.087742  1
2013 Torday JS, Insel PA. AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology. American Journal of Physiology. Cell Physiology. 305: C681. PMID 23824845 DOI: 10.1152/ajpcell.00200.2013  1
2013 Goldberg C, Insel PA. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Academic Medicine : Journal of the Association of American Medical Colleges. 88: 745-7. PMID 23708597 DOI: 10.1097/ACM.0b013e31828ffeeb  1
2013 Lu D, Insel PA. Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. The Journal of Biological Chemistry. 288: 19040-9. PMID 23677997 DOI: 10.1074/jbc.M113.466102  1
2013 Murray F, Insel PA. Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma. Expert Opinion On Therapeutic Targets. 17: 937-49. PMID 23647244 DOI: 10.1517/14728222.2013.798304  1
2013 Lotersztajn S, Insel PA. AJP-Cell begins a theme series on tissue fibrosis. American Journal of Physiology. Cell Physiology. 304: C215. PMID 23255579 DOI: 10.1152/ajpcell.00405.2012  1
2013 Insel PA. The past, present, and future of AJP-cell American Journal of Physiology - Cell Physiology. 304: C1. DOI: 10.1152/ajpcell.00356.2012  1
2013 Insel PA, Fuhs SR, Busija A, Roth DM, Patel HH. β-Adrenergic Receptors, Caveolae and Caveolins: Receptor Localization and Function Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 107. DOI: 10.1016/B978-0-12-800044-1.00093-3  1
2012 Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 51: 9323-32. PMID 23110364 DOI: 10.1021/bi301282k  1
2012 Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, ... ... Insel PA, et al. Mitochondria-localized caveolin in adaptation to cellular stress and injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4637-49. PMID 22859372 DOI: 10.1096/fj.12-215798  1
2012 Snead AN, Insel PA. Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4540-7. PMID 22859370 DOI: 10.1096/fj.12-213496  1
2012 Michel MC, Insel PA. Can you blame cold feet on Epac (and Rap1A)? Focus on "cyclic AMP-Rap1A signaling activates RhoA to induce α(2C)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells". American Journal of Physiology. Cell Physiology. 303: C488-9. PMID 22814395 DOI: 10.1152/ajpcell.00238.2012  1
2012 Rana BK, Bourne PE, Insel PA. Receptor databases and computational websites for ligand binding. Methods in Molecular Biology (Clifton, N.J.). 897: 1-13. PMID 22674158 DOI: 10.1007/978-1-61779-909-9_1  1
2012 Corriden R, Insel PA. New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signalling. 8: 587-98. PMID 22528684 DOI: 10.1007/s11302-012-9311-x  1
2012 Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 109: E1221-9. PMID 22493239 DOI: 10.1073/pnas.1202741109  1
2012 Burnstock G, Insel PA, Di Virgilio F. Special issue on cell and molecular biology of purinergic signalling: an introduction. Purinergic Signalling. 8: 341. PMID 22476941 DOI: 10.1007/s11302-012-9312-9  1
2012 Lu D, Soleymani S, Madakshire R, Insel PA. ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2580-91. PMID 22415310 DOI: 10.1096/fj.12-204677  1
2012 Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Martin B, Maudsley S, Shen RF. Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD). Journal of Proteomics. 75: 2480-7. PMID 22397766 DOI: 10.1016/j.jprot.2012.02.027  1
2012 Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. The Journal of Clinical Investigation. 122: 963-73. PMID 22326954 DOI: 10.1172/JCI59097  1
2012 Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. cAMP and Epac in the regulation of tissue fibrosis. British Journal of Pharmacology. 166: 447-56. PMID 22233238 DOI: 10.1111/j.1476-5381.2012.01847.x  1
2012 Insel PA, Snead A, Murray F, Zhang L, Yokouchi H, Katakia T, Kwon O, Dimucci D, Wilderman A. GPCR expression in tissues and cells: are the optimal receptors being used as drug targets? British Journal of Pharmacology. 165: 1613-6. PMID 21488863 DOI: 10.1111/j.1476-5381.2011.01434.x  1
2012 Insel PA, Zhang L, Murray F, Yokouchi H, Zambon AC. Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiologica (Oxford, England). 204: 277-87. PMID 21385327 DOI: 10.1111/j.1748-1716.2011.02273.x  1
2011 Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Maudsley S, Martin B, Shen RF. Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). Journal of the American Society For Mass Spectrometry. 22: 1753-62. PMID 21952889 DOI: 10.1007/s13361-011-0197-6  1
2011 Insel PA. β(2)-Adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation? Science Signaling. 4: pe37. PMID 21868355 DOI: 10.1126/scisignal.2002352  1
2011 Zambon AC, Wilderman A, Ho A, Insel PA. Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. The Journal of Biological Chemistry. 286: 33260-7. PMID 21808067 DOI: 10.1074/jbc.M111.268979  1
2011 Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. The Journal of Biological Chemistry. 286: 33310-21. PMID 21799010 DOI: 10.1074/jbc.M111.255976  1
2011 Peiró AM, Tang CM, Murray F, Zhang L, Brown LM, Chou D, Rassenti L, Kipps TJ, Kipps TA, Insel PA. Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease. Journal of Human Genetics. 56: 676-81. PMID 21796143 DOI: 10.1038/jhg.2011.80  1
2011 Kleyman TR, Insel PA, Frank M. Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos. American Journal of Physiology. Cell Physiology. 301: C749. PMID 21795524 DOI: 10.1152/ajpcell.00264.2011  1
2011 Murray F, Maclean MR, Insel PA. Role of phosphodiesterases in adult-onset pulmonary arterial hypertension. Handbook of Experimental Pharmacology. 279-305. PMID 21695645 DOI: 10.1007/978-3-642-17969-3_12  1
2011 Creighton J, Jian M, Sayner S, Alexeyev M, Insel PA. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3356-65. PMID 21680893 DOI: 10.1096/fj.10-179218  1
2011 Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel PA. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cellular Signalling. 23: 1611-6. PMID 21620962 DOI: 10.1016/j.cellsig.2011.05.014  1
2011 Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. Journal of the American College of Cardiology. 57: 2273-83. PMID 21616289 DOI: 10.1016/j.jacc.2010.12.032  1
2011 Rieg T, Gerasimova M, Boyer JL, Insel PA, Vallon V. P2Yâ‚‚ receptor activation decreases blood pressure and increases renal Na⁺ excretion. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R510-8. PMID 21613580 DOI: 10.1152/ajpregu.00148.2011  1
2011 Fuhs SR, Insel PA. Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization. The Journal of Biological Chemistry. 286: 14830-41. PMID 21362625 DOI: 10.1074/jbc.M110.214270  1
2011 Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, ... ... Insel PA, et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 471: 499-503. PMID 21346763 DOI: 10.1038/nature09884  1
2011 Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel PA. Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia. International Journal of Cancer. Journal International Du Cancer. 129: 1162-9. PMID 21120911 DOI: 10.1002/ijc.25785  1
2011 Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, ... ... Insel PA, et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (Nature (2011) 471 (499-501)) Nature. 474: 114. DOI: 10.1038/nature10088  1
2010 Levi M, Insel PA. AJP-Cell Physiology initiates publication of the Hans H. Ussing Lecture. American Journal of Physiology. Cell Physiology. 299: C1221. PMID 20881237 DOI: 10.1152/ajpcell.00391.2010  1
2010 Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. Journal of the American Society of Nephrology : Jasn. 21: 2059-68. PMID 20864687 DOI: 10.1681/ASN.2010040409  1
2010 Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O. Purinergic inhibition of ENaC produces aldosterone escape. Journal of the American Society of Nephrology : Jasn. 21: 1903-11. PMID 20813869 DOI: 10.1681/ASN.2010040377  1
2010 Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse Blood. 116: 3475-3484. PMID 20660288 DOI: 10.1182/blood-2010-04-277707  1
2010 Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. The Journal of Biological Chemistry. 285: 27632-40. PMID 20581396 DOI: 10.1074/jbc.M110.146589  1
2010 Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proceedings of the National Academy of Sciences of the United States of America. 107: 10638-43. PMID 20479237 DOI: 10.1073/pnas.1002348107  1
2010 Braun OO, Lu D, Aroonsakool N, Insel PA. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors Journal of Molecular and Cellular Cardiology. 49: 362-369. PMID 20471392 DOI: 10.1016/j.yjmcc.2010.05.001  1
2010 Insel PA. Historical perspectives in cell physiology: Looking back to help the discipline move forward American Journal of Physiology - Cell Physiology. 298: C1279. PMID 20237145 DOI: 10.1152/ajpcell.00082.2010  1
2010 Choi LJ, Jenikova G, Hanson E, Spehlmann ME, Boehling NS, Kirstein SL, Bundey RA, Smith JR, Insel PA, Eckmann L. Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G Protein (Gs) in intestinal epithelial cell differentiation Journal of Biological Chemistry. 285: 12504-12511. PMID 20157112 DOI: 10.1074/jbc.M109.059741  1
2010 Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone Faseb Journal. 24: 2056-2065. PMID 20097874 DOI: 10.1096/fj.09-151506  1
2010 Lotersztajn S, Insel PA. American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: Autophagy is the first theme American Journal of Physiology - Cell Physiology. 298: C775. PMID 20071687 DOI: 10.1152/ajpcell.00011.2010  1
2010 Corriden R, Insel PA. Basal release of ATP: An autocrine-paracrine mechanism for cell regulation Science Signaling. 3: re1. PMID 20068232 DOI: 10.1126/scisignal.3104re1  1
2010 Delpire E, Insel PA. AJP-Cell Physiology initiates publication of the Hugh Davson distinguished lecture American Journal of Physiology - Cell Physiology. 299: C875. DOI: 10.1152/ajpcell.00339.2010  1
2009 Braun OO, Insel PA. The Best "Model System" for Human (Coronary Arteries) Is Human Journal of the American College of Cardiology. 54: 1146-1148. PMID 19761934 DOI: 10.1016/j.jacc.2009.06.019  1
2009 Fung MM, Rana BK, Tang CM, Shiina T, Nievergelt CM, Rao F, Salem RM, Waalen J, Ziegler MG, Insel PA, O'Connor DT. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Kidney International. 76: 1070-80. PMID 19675531 DOI: 10.1038/ki.2009.306  1
2009 Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1685-93. PMID 19211924 DOI: 10.1096/fj.08-126458  1
2009 Insel PA, Patel HH. Membrane rafts and caveolae in cardiovascular signaling Current Opinion in Nephrology and Hypertension. 18: 50-56. PMID 19077689 DOI: 10.1097/MNH.0b013e3283186f82  1
2009 Dong X, Smoll EJ, Ko KH, Lee J, Chow JY, Kim HD, Insel PA, Dong H. P2Y receptors mediate Ca 2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion American Journal of Physiology - Gastrointestinal and Liver Physiology. 296: G424-G432. PMID 19074643 DOI: 10.1152/ajpgi.90314.2008  1
2009 Patel HH, Insel PA. Lipid rafts and caveolae and their role in compartmentation of redox signaling Antioxidants and Redox Signaling. 11: 1357-1372. PMID 19061440 DOI: 10.1089/ars.2008.2365  1
2008 Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia Proceedings of the National Academy of Sciences of the United States of America. 105: 19532-19537. PMID 19033455 DOI: 10.1073/pnas.0806152105  1
2008 Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD. Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone Journal of Biological Chemistry. 283: 36599-36607. PMID 18981175 DOI: 10.1074/jbc.M807129200  1
2008 Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning Circulation. 118: 1979-1988. PMID 18936328 DOI: 10.1161/CIRCULATIONAHA.108.788331  1
2008 Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine Journal of Biological Chemistry. 283: 28480-28486. PMID 18713747 DOI: 10.1074/jbc.M800039200  1
2008 Patel HH, Murray F, Insel PA. G-Protein-coupled receptor-signaling components in membrane raft and caveolae microdomains Handbook of Experimental Pharmacology. 186: 167-184. PMID 18491052 DOI: 10.1007/978-3-540-72843-6-7  1
2008 Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proceedings of the National Academy of Sciences of the United States of America. 105: 6386-91. PMID 18434542 DOI: 10.1073/pnas.0801490105  1
2008 Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JXJ. Regulation of pulmonary vasoconstriction by agonists and caveolae Experimental Lung Research. 34: 195-208. PMID 18432456 DOI: 10.1080/01902140801925471  1
2008 Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA, Vallon V. Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors American Journal of Physiology - Renal Physiology. 294: F638-F644. PMID 18199602 DOI: 10.1152/ajprenal.00344.2007  1
2008 Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury Journal of Molecular and Cellular Cardiology. 44: 123-130. PMID 18054955 DOI: 10.1016/j.yjmcc.2007.10.003  1
2008 Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. The Journal of Biological Chemistry. 283: 4304-13. PMID 18048352 DOI: 10.1074/jbc.M708673200  1
2008 Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules Annual Review of Pharmacology and Toxicology. 48: 359-391. PMID 17914930 DOI: 10.1146/annurev.pharmtox.48.121506.124841  1
2008 Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 828-40. PMID 17905724 DOI: 10.1096/fj.07-9299com  1
2008 Insel PA. AJP-Cell Physiology: The whole is greater than the sum of its parts American Journal of Physiology - Cell Physiology. 295: C1. DOI: 10.1152/ajpcell.zh0-5630.2008  1
2008 Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 17, (6386-6391) DOI: 10.1073/pnas.0801490105) Proceedings of the National Academy of Sciences of the United States of America. 105: 8160. DOI: 10.1073/pnas.0804100105  1
2007 Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction American Journal of Physiology - Heart and Circulatory Physiology. 293: H3216-H3220. PMID 17873016 DOI: 10.1152/ajpheart.00739.2007  1
2007 Insel PA. British paharmacology society 2nd focused meeting on cell signalling: GPCRs have summy days in springtime Leicester: 15-17 April, 2007, Leicester, UK Expert Opinion On Therapeutic Targets. 11: 1251-1253. PMID 17845149 DOI: 10.1517/14728222.11.9.1251  1
2007 Corriden R, Insel PA, Junger WG. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells American Journal of Physiology - Cell Physiology. 293: C1420-C1425. PMID 17699635 DOI: 10.1152/ajpcell.00271.2007  1
2007 Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption Faseb Journal. 21: 3717-3726. PMID 17575258 DOI: 10.1096/fj.07-8807com  1
2007 Steagall WK, Barrow BJ, Glasgow CG, Mendoza JW, Ehrmantraut M, Lin JP, Insel PA, Moss J. Beta-2-adrenergic receptor polymorphisms in cystic fibrosis Pharmacogenetics and Genomics. 17: 425-430. PMID 17502834 DOI: 10.1097/FPC.0b013e3280119349  1
2007 Patel HH, Zhang S, Murray F, Suda RYS, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JXJ, Insel PA. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension Faseb Journal. 21: 2970-2979. PMID 17470567 DOI: 10.1096/fj.07-8424com  1
2007 Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine Shock. 27: 242-250. PMID 17304104 DOI: 10.1097/01.shk.0000245014.96419.3a  1
2007 Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: A role for caveolae and caveolin-1 Faseb Journal. 21: 1565-1574. PMID 17272740 DOI: 10.1096/fj.06-7719com  1
2007 Arthur DB, Taupenot L, Insel PA. Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release Journal of Neurochemistry. 100: 1257-1264. PMID 17241236 DOI: 10.1111/j.1471-4159.2006.04305.x  1
2007 Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JXJ. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry American Journal of Physiology - Lung Cellular and Molecular Physiology. 292: L1202-L1210. PMID 17189322 DOI: 10.1152/ajplung.00214.2006  1
2007 Insel PA, Patel HH. Do studies in caveolin-knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for 'lost proteins'? British Journal of Pharmacology. 150: 251-254. PMID 17179949 DOI: 10.1038/sj.bjp.0706981  1
2007 Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, Schork NJ, O'Connor DT. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension. 49: 96-106. PMID 17159089 DOI: 10.1161/01.HYP.0000252029.35106.67  1
2007 Head BP, Insel PA. Do caveolins regulate cells by actions outside of caveolae? Trends in Cell Biology. 17: 51-57. PMID 17150359 DOI: 10.1016/j.tcb.2006.11.008  1
2007 Insel PA, Tang CM, Hahntow I, Michel MC. Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets Biochimica Et Biophysica Acta - Biomembranes. 1768: 994-1005. PMID 17081496 DOI: 10.1016/j.bbamem.2006.09.029  1
2007 Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L294-303. PMID 16980375 DOI: 10.1152/ajplung.00190.2006  1
2006 Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (New York, N.Y.). 314: 1792-5. PMID 17170310 DOI: 10.1126/science.1132559  1
2006 Akimova OA, Grygorczyk A, Bundey RA, Bourcier N, Gekle M, Insel PA, Orlov SN. Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. The Journal of Biological Chemistry. 281: 31317-25. PMID 16916802 DOI: 10.1074/jbc.M602117200  1
2006 Bundey RA, Insel PA. Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Molecular Pharmacology. 70: 1700-7. PMID 16885208 DOI: 10.1124/mol.106.028035  1
2006 Ostrom RS, Insel PA. Methods for the study of signaling molecules in membrane lipid rafts and caveolae. Methods in Molecular Biology (Clifton, N.J.). 332: 181-91. PMID 16878693 DOI: 10.1385/1-59745-048-0:181  1
2006 Arthur DB, Akassoglou K, Insel PA. P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochemical and Biophysical Research Communications. 347: 678-82. PMID 16842754 DOI: 10.1016/j.bbrc.2006.06.141  1
2006 Hoekstra HE, Hirschmann RJ, Bundey RA, Insel PA, Crossland JP. A single amino acid mutation contributes to adaptive beach mouse color pattern. Science (New York, N.Y.). 313: 101-4. PMID 16825572 DOI: 10.1126/science.1126121  1
2006 Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. The Journal of Biological Chemistry. 281: 26391-9. PMID 16818493 DOI: 10.1074/jbc.M602577200  1
2006 Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. The Journal of Biological Chemistry. 281: 17173-9. PMID 16618703 DOI: 10.1074/jbc.M513097200  1
2006 Arthur DB, Georgi S, Akassoglou K, Insel PA. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3798-804. PMID 16597733 DOI: 10.1523/JNEUROSCI.5338-05.2006  1
2006 Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. American Journal of Physiology. Heart and Circulatory Physiology. 291: H344-50. PMID 16501018 DOI: 10.1152/ajpheart.01100.2005  1
2006 Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenetics and Genomics. 16: 199-205. PMID 16495779 DOI: 10.1097/01.fpc.0000189798.11468.6a  1
2006 Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension. 47: 415-20. PMID 16432041 DOI: 10.1161/01.HYP.0000200714.81990.61  1
2006 Murray F, Insel PA, Yuan JX. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respiratory Physiology & Neurobiology. 151: 192-208. PMID 16364695 DOI: 10.1016/j.resp.2005.10.003  1
2005 Arthur DB, Akassoglou K, Insel PA. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 102: 19138-43. PMID 16365320 DOI: 10.1073/pnas.0505913102  1
2005 Tang CM, Insel PA. Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets. Expert Opinion On Therapeutic Targets. 9: 1247-65. PMID 16300474 DOI: 10.1517/14728222.9.6.1247  1
2005 Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochemical Society Transactions. 33: 1131-4. PMID 16246064 DOI: 10.1042/BST20051131  1
2005 Akimova AO, Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, Orlov SN. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. The Journal of Physiology. 568: 789-801. PMID 16109726 DOI: 10.1113/jphysiol.2005.094375  1
2005 Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Annals of the New York Academy of Sciences. 1047: 166-72. PMID 16093494 DOI: 10.1196/annals.1341.015  1
2005 Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. The Journal of Biological Chemistry. 280: 31036-44. PMID 15961389 DOI: 10.1074/jbc.M502540200  1
2005 Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 102: 8561-6. PMID 15939874 DOI: 10.1073/pnas.0503363102  1
2005 Etzel JP, Rana BK, Wen G, Parmer RJ, Schork NJ, O'Connor DT, Insel PA. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 45: 1207-13. PMID 15920038 DOI: 10.1161/01.HYP.0000166721.42734.49  1
2005 King D, Etzel JP, Chopra S, Smith J, Cadman PE, Rao F, Funk SD, Rana BK, Schork NJ, Insel PA, O'Connor DT. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. Clinical Pharmacology and Therapeutics. 77: 388-403. PMID 15900285 DOI: 10.1016/j.clpt.2005.02.008  1
2005 Rana BK, Insel PA. Receptor databases and computational websites for ligand binding. Methods in Molecular Biology (Clifton, N.J.). 306: 1-15. PMID 15867461 DOI: 10.1385/1-59259-927-3:001  1
2005 Tang CM, Hoerning A, Büscher R, O'Connor DT, Ratjen F, Grasemann H, Insel PA. Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenetics and Genomics. 15: 321-7. PMID 15864133  1
2005 Riddle EL, Schwartzman RA, Bond M, Insel PA. Multi-tasking RGS proteins in the heart: the next therapeutic target? Circulation Research. 96: 401-11. PMID 15746448 DOI: 10.1161/01.RES.0000158287.49872.4e  1
2005 Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel PA. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 102: 437-42. PMID 15625103 DOI: 10.1073/pnas.0408704102  1
2005 Conner AC, Hay DL, Simms J, Howitt SG, Schindler M, Smith DM, Wheatley M, Poyner DR. A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. Molecular Pharmacology. 67: 20-31. PMID 15615699 DOI: 10.1124/mol.67.1.  1
2004 Siecke NW, Insel PA. Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters. Journal of the American College of Cardiology. 44: 2016-8. PMID 15542285 DOI: 10.1016/j.jacc.2004.09.001  1
2004 Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. Blasts from the past. The Journal of Clinical Investigation. 114: 1017-33. PMID 15489944 DOI: 10.1172/JCI23321  1
2004 Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar TP, Ho H, Leverge R, Smith DW, Ziegler MG, Insel PA, Schork NJ, Flockhart DA, O'connor DT. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clinical Pharmacology and Therapeutics. 76: 139-53. PMID 15289791 DOI: 10.1016/j.clpt.2004.04.010  1
2004 Ostrom RS, Insel PA. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. British Journal of Pharmacology. 143: 235-45. PMID 15289291 DOI: 10.1038/sj.bjp.0705930  1
2004 Bundey RA, Insel PA. Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP? Science's Stke : Signal Transduction Knowledge Environment. 2004: pe19. PMID 15126677 DOI: 10.1126/stke.2312004pe19  1
2004 Tang CM, Insel PA. GPCR expression in the heart; "new" receptors in myocytes and fibroblasts. Trends in Cardiovascular Medicine. 14: 94-9. PMID 15121156 DOI: 10.1016/j.tcm.2003.12.007  1
2004 Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. Journal of Leukocyte Biology. 76: 245-53. PMID 15107462 DOI: 10.1189/jlb.0204066  1
2004 Nishihara H, Hwang M, Kizaka-Kondoh S, Eckmann L, Insel PA. Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. The Journal of Biological Chemistry. 279: 26176-83. PMID 15078890 DOI: 10.1074/jbc.M313346200  1
2004 Liu X, Ostrom RS, Insel PA. cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. American Journal of Physiology. Cell Physiology. 286: C1089-99. PMID 15075208 DOI: 10.1152/ajpcell.00461.2003  1
2004 Ostrom RS, Bundey RA, Insel PA. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. The Journal of Biological Chemistry. 279: 19846-53. PMID 15007069 DOI: 10.1074/jbc.M313440200  1
2004 Kirstein SL, Insel PA. Autonomic nervous system pharmacogenomics: a progress report. Pharmacological Reviews. 56: 31-52. PMID 15001662 DOI: 10.1124/pr.56.1.2  1
2004 Zhang L, Insel PA. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. The Journal of Biological Chemistry. 279: 20858-65. PMID 14996839 DOI: 10.1074/jbc.M310643200  1
2004 Insel PA. Molecular Pharmacology: Editor's Note Molecular Pharmacology. 65: 1. DOI: 10.1124/mol.65.1.1  1
2003 Insel PA, Kirstein SL. Naturally occurring variants in catecholamine receptor genes. Autonomic & Autacoid Pharmacology. 23: 228-30. PMID 15132132  1
2003 Koopmans RP, Insel PA, Michel MC. Pharmacogenetics of hypertension treatment: a structured review. Pharmacogenetics. 13: 705-13. PMID 14646689 DOI: 10.1097/01.fpc.0000054142.14659.f3  1
2003 Brindikova TA, Bourcier N, Torres B, Pchejetski D, Gekle M, Maximov GV, Montminy V, Insel PA, Orlov SN, Isenring P. Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter. American Journal of Physiology. Cell Physiology. 285: C1445-53. PMID 12917108 DOI: 10.1152/ajpcell.00386.2002  1
2003 Bundey RA, Insel PA. Quantification of adenylyl cyclase messenger RNA by real-time polymerase chain reaction. Analytical Biochemistry. 319: 318-22. PMID 12871728 DOI: 10.1016/S0003-2697(03)00325-7  1
2003 Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 8921-6. PMID 12837940 DOI: 10.1073/pnas.1533221100  1
2003 Insel PA, Ostrom RS. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cellular and Molecular Neurobiology. 23: 305-14. PMID 12825829 DOI: 10.1023/A:1023684503883  1
2003 Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. The Journal of Biological Chemistry. 278: 24461-8. PMID 12711600 DOI: 10.1074/jbc.M212659200  1
2003 Insel PA. Location, location, location. Trends in Endocrinology and Metabolism: Tem. 14: 100-2. PMID 12670730 DOI: 10.1016/S1043-2760(03)00029-8  1
2003 Lee A, Rana BK, Schiffer HH, Schork NJ, Brann MR, Insel PA, Weiner DM. Distribution analysis of nonsynonymous polymorphisms within the G-protein-coupled receptor gene family. Genomics. 81: 245-8. PMID 12659808 DOI: 10.1016/S0888-7543(03)00009-0  1
2003 Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LO, Jensen RV, Gullans SR, Insel PA, Nithipatikom K, Gross GJ. 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. Circulation Research. 92: 676-82. PMID 12623876 DOI: 10.1161/01.RES.0000065167.52922.F6  1
2003 Bruck H, Leineweber K, Büscher R, Ulrich A, Radke J, Insel PA, Brodde OE. The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics. 13: 59-66. PMID 12563174 DOI: 10.1097/00008571-200302000-00001  1
2003 Michel MC, Insel PA. Receptor gene polymorphisms: lessons on functional relevance from the beta 1-adrenoceptor. British Journal of Pharmacology. 138: 279-82. PMID 12540516 DOI: 10.1038/sj.bjp.0705031  1
2003 Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. The Journal of Biological Chemistry. 278: 4590-6. PMID 12464620 DOI: 10.1074/jbc.M207868200  1
2003 Hughes RJ, Torres B, Zambon A, Arthur D, Bohmann C, Rump LC, Insel PA. Expression of multiple P2Y receptors by MDCK-D1 cells: P2Y1 receptor cloning and signaling Drug Development Research. 59: 1-7. DOI: 10.1002/ddr.10196  1
2002 Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Molecular Pharmacology. 62: 983-92. PMID 12391260 DOI: 10.1124/mol.62.5.983  1
2002 Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel PA, Ratjen F. beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 12: 347-53. PMID 12142724 DOI: 10.1097/00008571-200207000-00002  1
2002 Torres B, Zambon AC, Insel PA. P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D(1) cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. The Journal of Biological Chemistry. 277: 7761-5. PMID 11788591 DOI: 10.1074/jbc.M110352200  1
2002 Ostrom RS, Rana BK, Insel PA. Stoichiometry of G protein-coupled receptor signaling: Implications in the genomic era Pharmaceutical News. 9: 295-303. DOI: 10.1080/10718940216630  1
2001 Rana BK, Insel PA. Useful G-protein-coupled receptor websites. Trends in Pharmacological Sciences. 22: 485-6. PMID 12613478  1
2001 Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science (New York, N.Y.). 294: 1939-42. PMID 11729322 DOI: 10.1126/science.1064757  1
2001 Qi AD, Zambon AC, Insel PA, Nicholas RA. An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors. Molecular Pharmacology. 60: 1375-82. PMID 11723245  1
2001 Zhang L, Insel PA. Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone. American Journal of Physiology. Cell Physiology. 281: C1642-7. PMID 11600428  1
2001 Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. The Journal of Biological Chemistry. 276: 42063-9. PMID 11533056 DOI: 10.1074/jbc.M105348200  1
2001 Ostrom RS, Gregorian C, Drenan RM, Gabot K, Rana BK, Insel PA. Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP. American Journal of Physiology. Cell Physiology. 281: C524-31. PMID 11443051  1
2001 Rana BK, Pan L, Insel PA. Use of an in silico approach to define the gene structure of eukaryotic adenylyl cyclases. Biochemical and Biophysical Research Communications. 285: 152-7. PMID 11437386 DOI: 10.1006/bbrc.2001.5096  1
2001 Zambon AC, Brunton LL, Barrett KE, Hughes RJ, Torres B, Insel PA. Cloning, expression, signaling mechanisms, and membrane targeting of P2Y(11) receptors in Madin Darby canine kidney cells. Molecular Pharmacology. 60: 26-35. PMID 11408597  1
2001 Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, Post SR. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clinical and Experimental Pharmacology & Physiology. 28: 351-4. PMID 11339212 DOI: 10.1046/j.1440-1681.2001.03452.x  1
2001 Büscher R, Belger H, Eilmes KJ, Tellkamp R, Radke J, Dhein S, Hoyer PF, Michel MC, Insel PA, Brodde OE. In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans. Pharmacogenetics. 11: 199-205. PMID 11337935 DOI: 10.1097/00008571-200104000-00003  1
2001 Rana BK, Shiina T, Insel PA. Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. Annual Review of Pharmacology and Toxicology. 41: 593-624. PMID 11264470 DOI: 10.1146/annurev.pharmtox.41.1.593  1
2001 Brodde OE, Büscher R, Tellkamp R, Radke J, Dhein S, Insel PA. Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors. Circulation. 103: 1048-50. PMID 11222464  1
2000 Zambon AC, Hughes RJ, Meszaros JG, Wu JJ, Torres B, Brunton LL, Insel PA. P2Y(2) receptor of MDCK cells: cloning, expression, and cell-specific signaling. American Journal of Physiology. Renal Physiology. 279: F1045-52. PMID 11097622  1
2000 Glew RH, Insel PA. Academic health center administrators don't perish when they don't publish. Academic Medicine : Journal of the Association of American Medical Colleges. 75: 996-8. PMID 11031144  1
2000 Yan L, Herrmann V, Hofer JK, Insel PA. beta-adrenergic receptor/cAMP-mediated signaling and apoptosis of S49 lymphoma cells. American Journal of Physiology. Cell Physiology. 279: C1665-74. PMID 11029315  1
2000 O'Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. Heredity and the autonomic nervous system in human hypertension. Current Hypertension Reports. 2: 16-22. PMID 10982526 DOI: 10.1007/s11906-000-0053-8  1
2000 Herrmann V, Büscher R, Go MM, Ring KM, Hofer JK, Kailasam MT, O'Connor DT, Parmer RJ, Insel PA. Beta2-adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in whites and African Americans. American Journal of Hypertension. 13: 1021-6. PMID 10981553 DOI: 10.1016/S0895-7061(00)01188-2  1
2000 Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616  1
2000 Ostrom RS, Post SR, Insel PA. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). The Journal of Pharmacology and Experimental Therapeutics. 294: 407-12. PMID 10900212  1
2000 Horie K, Insel PA. Retrovirally mediated transfer of a G protein-coupled receptor kinase (GRK) dominant-negative mutant enhances endogenous calcitonin receptor signaling in Chinese hamster ovary cells. GRK inhibition enhances expression of receptors and receptor mRNA. The Journal of Biological Chemistry. 275: 29433-40. PMID 10889199 DOI: 10.1074/jbc.M003413200  1
2000 Ostrom RS, Violin JD, Coleman S, Insel PA. Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Molecular Pharmacology. 57: 1075-9. PMID 10779394  1
2000 Ostrom RS, Gregorian C, Insel PA. Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways. The Journal of Biological Chemistry. 275: 11735-9. PMID 10766795 DOI: 10.1074/jbc.275.16.11735  1
2000 Post SR, Ostrom RS, Insel PA. Biochemical methods for detection and measurement of cyclic AMP and adenylyl cyclase activity. Methods in Molecular Biology (Clifton, N.J.). 126: 363-74. PMID 10685423  1
2000 Shehnaz D, Torres B, Balboa MA, Insel PA. Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a putative P2Y(1) receptor antagonist, blocks signaling at a site distal to the receptor in Madin-Darby canine kidney-D(1) cells. The Journal of Pharmacology and Experimental Therapeutics. 292: 346-50. PMID 10604969  1
1999 Büscher R, Herrmann V, Ring KM, Kailasam MT, O'Connor DT, Parmer RJ, Insel PA. Variability in phenylephrine response and essential hypertension: a search for human alpha(1B)-adrenergic receptor polymorphisms. The Journal of Pharmacology and Experimental Therapeutics. 291: 793-8. PMID 10525102  1
1999 Post SR, Hammond HK, Insel PA. Beta-adrenergic receptors and receptor signaling in heart failure. Annual Review of Pharmacology and Toxicology. 39: 343-60. PMID 10331088 DOI: 10.1146/annurev.pharmtox.39.1.343  1
1999 Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospholipase A2. Annual Review of Pharmacology and Toxicology. 39: 175-89. PMID 10331081 DOI: 10.1146/annurev.pharmtox.39.1.175  1
1999 Ostrom RS, Insel PA. Caveolar microdomains of the sarcolemma: compartmentation of signaling molecules comes of age. Circulation Research. 84: 1110-2. PMID 10325248  1
1999 Büscher R, Herrmann V, Insel PA. Human adrenoceptor polymorphisms: evolving recognition of clinical importance. Trends in Pharmacological Sciences. 20: 94-9. PMID 10203863 DOI: 10.1016/S0165-6147(99)01322-X  1
1999 Xing M, Post S, Ostrom RS, Samardzija M, Insel PA. Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells. The Journal of Biological Chemistry. 274: 10035-8. PMID 10187781 DOI: 10.1074/jbc.274.15.10035  1
1998 Büscher R, Herrmann V, Insel PA. PCR-based methods for identifying genetic variations in human alpha1B- and beta2-adrenergic receptors. Molecular Genetics and Metabolism. 64: 266-70. PMID 9758717 DOI: 10.1006/mgme.1998.2719  1
1998 Post SR, Rump LC, Zambon A, Hughes RJ, Buda MD, Jacobson JP, Kao CC, Insel PA. ATP activates cAMP production via multiple purinergic receptors in MDCK-D1 epithelial cells. Blockade of an autocrine/paracrine pathway to define receptor preference of an agonist. The Journal of Biological Chemistry. 273: 23093-7. PMID 9722536 DOI: 10.1074/jbc.273.36.23093  1
1998 Dao TT, Kailasam MT, Parmer RJ, Le HV, Le Verge R, Kennedy BP, Ziegler G, Insel PA, Wright FA, O'Connor DT. Expression of altered alpha2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension. Journal of Hypertension. 16: 779-92. PMID 9663918 DOI: 10.1097/00004872-199816060-00009  1
1998 Yang M, Büscher R, Taguchi K, Grübbel B, Insel PA, Michel MC. Protein kinase C does not mediate phenylephrine-induced down-regulation of Madin-Darby canine kidney cell alpha-1B adrenoceptors. The Journal of Pharmacology and Experimental Therapeutics. 286: 36-43. PMID 9655839  1
1998 Balboa MA, Insel PA. Stimulation of phospholipase D via alpha1-adrenergic receptors in Madin-Darby canine kidney cells is independent of PKCalpha and -epsilon activation. Molecular Pharmacology. 53: 221-7. PMID 9463479  0.32
1998 Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 95: 1038-43. PMID 9448281 DOI: 10.1073/pnas.95.3.1038  1
1998 Hammond HK, Ping P, Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist. Advances in Pharmacology (San Diego, Calif.). 42: 507-10. PMID 9327951  1
1998 Insel PA, Balboa MA, Mochizuki N, Post SR, Urasawa K, Xing M. Mechanisms for activation of multiple effectors by alpha 1-adrenergic receptors. Advances in Pharmacology (San Diego, Calif.). 42: 451-3. PMID 9327936  0.48
1997 Hughes RJ, Pasillas M, Saiz J, Jasper J, Insel PA. Decreased transcript expression coincident with impaired glycosylation in the beta2-adrenergic receptor gene does not result from differences in the primary sequence. Biochimica Et Biophysica Acta. 1356: 281-91. PMID 9194571  0.48
1997 Xing M, Tao L, Insel PA. Role of extracellular signal-regulated kinase and PKC alpha in cytosolic PLA2 activation by bradykinin in MDCK-D1 cells. The American Journal of Physiology. 272: C1380-7. PMID 9142865  0.48
1997 Xing M, Firestein BL, Shen GH, Insel PA. Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P2U receptors in MDCK-D1 cells: involvement of MAP kinase-dependent and -independent pathways. The Journal of Clinical Investigation. 99: 805-14. PMID 9045886 DOI: 10.1172/JCI119227  1
1997 Varki AP, Kagnoff MF, Insel PA. Passing the baton at high speed: time to hand over to a new editorial board. The Journal of Clinical Investigation. 99: 553-4. PMID 9045851 DOI: 10.1172/JCI119192  1
1997 Balsinde J, Balboa MA, Insel PA, Dennis EA. Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages. The Biochemical Journal. 321: 805-9. PMID 9032469  0.32
1996 Insel PA, Firestein BL, Xing M, Post SR, Jacobson JP, Balboa MA, Hughes RJ. P2-purinoceptors utilize multiple signalling pathways in MDCK-D1 cells. Journal of Autonomic Pharmacology. 16: 311-3. PMID 9131405  1
1996 Firestein BL, Xing M, Hughes RJ, Corvera CU, Insel PA. Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells. The American Journal of Physiology. 271: F610-8. PMID 8853423  1
1996 Godson C, Masliah E, Balboa MA, Ellisman MH, Insel PA. Isoform-specific redistribution of protein kinase C in living cells. Biochimica Et Biophysica Acta. 1313: 63-71. PMID 8781551  0.32
1996 Denker SP, McCaffery JM, Palade GE, Insel PA, Farquhar MG. Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. The Journal of Cell Biology. 133: 1027-40. PMID 8655576  1
1996 Hughes RJ, Anderson KL, Kiel D, Insel PA. Cloning of GRK2 cDNA from S49 murine lymphoma cells. The American Journal of Physiology. 270: C885-91. PMID 8638670  1
1996 Xing M, Insel PA. Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells. The Journal of Clinical Investigation. 97: 1302-10. PMID 8636443 DOI: 10.1172/JCI118546  0.48
1996 Post SR, Jacobson JP, Insel PA. P2 purinergic receptor agonists enhance cAMP production in Madin-Darby canine kidney epithelial cells via an autocrine/paracrine mechanism. The Journal of Biological Chemistry. 271: 2029-32. PMID 8567655  0.32
1996 Post SR, Aguila-Buhain O, Insel PA. A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells. The Journal of Biological Chemistry. 271: 895-900. PMID 8557702  0.32
1995 Balboa MA, Insel PA. Nuclear phospholipase D in Madin-Darby canine kidney cells. Guanosine 5'-O-(thiotriphosphate)-stimulated activation is mediated by RhoA and is downstream of protein kinase C. The Journal of Biological Chemistry. 270: 29843-7. PMID 8530380  0.32
1995 Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. The Journal of Clinical Investigation. 95: 1271-80. PMID 7883975 DOI: 10.1172/JCI117777  1
1995 Jasper JR, Post SR, Desai KH, Insel PA, Bernstein D. Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions. The Journal of Pharmacology and Experimental Therapeutics. 274: 937-42. PMID 7636757  0.32
1995 Post SR, Hilal-Dandan R, Urasawa K, Brunton LL, Insel PA. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. The Biochemical Journal. 311: 75-80. PMID 7575483  0.4
1995 Balboa MA, Balsinde J, Dennis EA, Insel PA. A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 11738-40. PMID 7538121  0.32
1994 Balboa MA, Firestein BL, Godson C, Bell KS, Insel PA. Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2. The Journal of Biological Chemistry. 269: 10511-6. PMID 8144636  1
1993 Insel PA, Hammond HK. Beta-adrenergic receptors in heart failure. The Journal of Clinical Investigation. 92: 2564. PMID 8254011 DOI: 10.1172/JCI116867  1
1993 Jackson CA, Insel PA. Renal alpha-adrenergic receptors and genetic hypertension. Pediatric Nephrology (Berlin, Germany). 7: 853-8. PMID 8130120 DOI: 10.1007/BF01213373  1
1992 Roth DA, Urasawa K, Leiber D, Insel PA, Hammond HK. A substantial proportion of cardiac Gs is not associated with the plasma membrane. Febs Letters. 296: 46-50. PMID 1730290 DOI: 10.1016/0014-5793(92)80400-B  1
1992 Jackson CA, Michel MC, Insel PA. Expression of renal alpha 1-adrenergic receptor subtypes in established hypertension. Journal of Cardiovascular Pharmacology. 19: 857-62. PMID 1376804  1
1992 Hammond HK, Roth DA, Insel PA, Ford CE, White FC, Maisel AS, Ziegler MG, Bloor CM. Myocardial beta-adrenergic receptor expression and signal transduction after chronic volume-overload hypertrophy and circulatory congestion. Circulation. 85: 269-80. PMID 1309445  1
1991 Hughes RJ, Howard MJ, Allen JM, Insel PA. Decreased beta 2-adrenergic receptor mRNA expression in receptor-deficient S49 lymphoma cells. Molecular Pharmacology. 40: 974-9. PMID 1661841  1
1991 Insel PA, Weiss BA, Slivka SR, Howard MJ, Waite JJ, Godson CA. Regulation of phospholipase A2 by receptors in MDCK-Dl cells. Biochemical Society Transactions. 19: 329-33. PMID 1653734  1
1990 Waite JJ, Insel PA. G-protein linked polyphosphoinositide phospholipase C activity in cell membranes from clonally derived and ras-transformed Madin-Darby canine kidney cells. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 68: 1119-27. PMID 2175200  1
1990 Howard MJ, Insel PA. Elevated extracellular K+ enhances arachidonic acid release in MDCK-D1 cells. The American Journal of Physiology. 259: C224-31. PMID 2166433  1
1990 Maisel AS, Michel MC, Insel PA, Ennis C, Ziegler MG, Phillips C. Pertussis toxin treatment of whole blood. A novel approach to assess G protein function in congestive heart failure. Circulation. 81: 1198-204. PMID 2156637  1
1990 Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ. Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors. Molecular Pharmacology. 37: 65-8. PMID 2153910  1
1988 Hughes RJ, Mahan LC, Insel PA. Certain beta-blockers can decrease beta-adrenergic receptor number: II. Down-regulation of receptor number by alprenolol and propranolol in cultured lymphoma and muscle cells. Circulation Research. 63: 279-85. PMID 2899462  0.48
1988 Hammond HK, Ransnas LA, Insel PA. Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, chronic dynamic exercise. The Journal of Clinical Investigation. 82: 2168-71. PMID 2848869 DOI: 10.1172/JCI113840  1
1988 Slivka SR, Meier KE, Insel PA. Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C. The Journal of Biological Chemistry. 263: 12242-6. PMID 2842326  1
1988 Hughes RJ, Struthers RS, Fong AM, Insel PA. Receptor-induced degradation of atrial natriuretic peptide by a rabbit carotid artery smooth muscle cell. Molecular Endocrinology (Baltimore, Md.). 2: 117-24. PMID 2840569 DOI: 10.1210/mend-2-2-117  1
1987 McKernan RM, Howard MJ, Motulsky HJ, Insel PA. Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. Molecular Pharmacology. 32: 258-65. PMID 3039340  1
1987 Howard MJ, Mullen MD, Insel PA. Amiloride interacts with renal alpha- and beta-adrenergic receptors. The American Journal of Physiology. 253: F21-5. PMID 3037921  1
1987 Howard MJ, Hughes RJ, Motulsky HJ, Mullen MD, Insel PA. Interactions of amiloride with alpha- and beta-adrenergic receptors: amiloride reveals an allosteric site on alpha 2-adrenergic receptors. Molecular Pharmacology. 32: 53-8. PMID 3037303  1
1987 Terman BI, Slivka SR, Hughes RJ, Insel PA. Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells. Molecular Pharmacology. 31: 12-20. PMID 3027523  0.48
1987 Nord EP, Howard MJ, Hafezi A, Moradeshagi P, Vaystub S, Insel PA. Alpha 2 adrenergic agonists stimulate Na+-H+ antiport activity in the rabbit renal proximal tubule. The Journal of Clinical Investigation. 80: 1755-62. PMID 2890661 DOI: 10.1172/JCI113268  1
1987 Hughes RJ, Struthers RS, Fong AM, Insel PA. Regulation of the atrial natriuretic peptide receptor on a smooth muscle cell. The American Journal of Physiology. 253: C809-16. PMID 2827497  1
1986 Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood. 68: 1224-31. PMID 3779100  1
1986 Hughes RJ, Insel PA. Agonist-mediated regulation of alpha 1- and beta 2-adrenergic receptor metabolism in a muscle cell line, BC3H-1. Molecular Pharmacology. 29: 521-30. PMID 3012317  0.48
1985 Healy DP, Münzel PA, Insel PA. Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography. Circulation Research. 57: 278-84. PMID 2990758  1
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