| Year |
Citation |
Score |
| 2023 |
Panettieri RA, Stanford SC, Alexander S, Cirino G, George CH, Insel PA, Kendall D, Ji Y, Patel HH, Sobey CG, Stefanska B, Stephens G, Teixeira M, Vergnolle N, Ferdinandy P, et al. BJP recommendations for publishing research on tobacco smoke and environmental tobacco smoke exposure. British Journal of Pharmacology. PMID 37092682 DOI: 10.1111/bph.16089 |
0.398 |
|
| 2023 |
Stanford SC, Alexander S, Cirino G, George CH, Insel PA, Kendall D, Ji Y, Panettieri RA, Patel HH, Sobey CG, Stefanska B, Stephens G, Teixeira M, Vergnolle N, Ferdinandy P, et al. Considering and reporting sex as an experimental variable II: An update on progress in the British Journal of Pharmacology. British Journal of Pharmacology. PMID 36876456 DOI: 10.1111/bph.16049 |
0.425 |
|
| 2022 |
Ingrande J, Patel HH, Kendall D, Stefanska B, Alexander S, Bakhle M, Cirino G, Docherty JR, George CH, Insel PA, Ji Y, King BF, Lilley E, Panettieri RA, Ramage AG, et al. Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. British Journal of Pharmacology. PMID 36529953 DOI: 10.1111/bph.15992 |
0.435 |
|
| 2022 |
Curtis MJ, Alexander SPH, Cirino G, George CH, Kendall DA, Insel PA, Izzo AA, Ji Y, Panettieri RA, Patel HH, Sobey CG, Stanford SC, Stanley P, Stefanska B, Stephens GJ, et al. Planning experiments: Updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology. PMID 35673806 DOI: 10.1111/bph.15868 |
0.421 |
|
| 2021 |
George CH, Alexander SPH, Cirino G, Insel PA, Izzo AA, Ji Y, Kendall DA, Panettieri RA, Patel HH, Sobey CG, Stanford SC, Stefanska B, Stephens G, Teixeira M, Ahluwalia A. Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). British Journal of Pharmacology. PMID 34328225 DOI: 10.1111/bph.15589 |
0.412 |
|
| 2020 |
Sriram K, Insel PA. Assessment of ACE inhibitors/angiotensin receptor blockers in COVID-19 patients. American Journal of Physiology. Lung Cellular and Molecular Physiology. 319: L37-L38. PMID 33496632 DOI: 10.1152/ajplung.00262.2020 |
0.332 |
|
| 2020 |
Sriram K, Insel PA. Proteinase-activated receptor 1: A target for repurposing in the treatment of COVID-19? British Journal of Pharmacology. PMID 32639031 DOI: 10.1111/bph.15194 |
0.383 |
|
| 2020 |
Sriram K, Insel PA. A hypothesis for pathobiology and treatment of COVID-19: the centrality of ACE1/ACE2 imbalance. British Journal of Pharmacology. PMID 32333398 DOI: 10.1111/bph.15082 |
0.315 |
|
| 2020 |
Sriram K, Insel PA. Risks of ACE inhibitor and ARB usage in COVID-19: evaluating the evidence. Clinical Pharmacology and Therapeutics. PMID 32320478 DOI: 10.1002/cpt.1863 |
0.329 |
|
| 2020 |
Insel PA, Sriram K, Salmerón C, Wiley SZ. Proton-sensing G protein-coupled receptors: detectors of tumor acidosis and candidate drug targets. Future Medicinal Chemistry. PMID 32116003 DOI: 10.4155/fmc-2019-0357 |
0.324 |
|
| 2020 |
Sriram K, Salmeron CS, Wiley SZ, Insel PA. GPCRs in pancreatic adenocarcinoma: Contributors to tumor biology and novel therapeutic targets. British Journal of Pharmacology. PMID 32060895 DOI: 10.1111/bph.15028 |
0.333 |
|
| 2020 |
Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, et al. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 9. PMID 32014112 DOI: 10.7554/eLife.49416 |
0.348 |
|
| 2020 |
Salmerón C, Sriram K, Baird A, Insel PA. Abstract 5160: A GPCR candidate in pancreatic ductal adenocarcinoma: A potential repurposing opportunity Cancer Research. 80: 5160-5160. DOI: 10.1158/1538-7445.Am2020-5160 |
0.367 |
|
| 2019 |
Sriram K, Moyung K, Corriden R, Carter H, Insel PA. GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors. Plos Biology. 17: e3000434. PMID 31765370 DOI: 10.1371/Journal.Pbio.3000434 |
0.688 |
|
| 2019 |
Insel PA, Sriram K, Gorr MW, Wiley SZ, Michkov A, Salmerón C, Chinn AM. GPCRomics: An Approach to Discover GPCR Drug Targets. Trends in Pharmacological Sciences. PMID 31078319 DOI: 10.1016/j.tips.2019.04.001 |
0.323 |
|
| 2019 |
Mukherjee S, Sheng W, Michkov A, Sriarm K, Sun R, Dvorkin-Gheva A, Insel PA, Janssen LJ. Prostaglandin E2 inhibits pro-fibrotic function of human pulmonary fibroblasts by disrupting Ca2+-signaling. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30758990 DOI: 10.1152/ajplung.00403.2018 |
0.406 |
|
| 2019 |
Wiley SZ, Sriram K, Salmerón C, Insel PA. GPR68: An Emerging Drug Target in Cancer. International Journal of Molecular Sciences. 20. PMID 30696114 DOI: 10.3390/ijms20030559 |
0.336 |
|
| 2019 |
Wiley SZ, Sriram K, Salmeron-Salvador C, Nishihara H, French R, Lowy AM, Insel PA. Abstract 118: GPR68, a proton-sensing GPCR that mediates interaction of pancreatic cancer associated fibroblasts and cancer cells, is a potential therapeutic target for pancreatic cancer Cancer Research. 79: 118-118. DOI: 10.1158/1538-7445.Am2019-118 |
0.315 |
|
| 2018 |
Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Frontiers in Pharmacology. 9: 431. PMID 29872392 DOI: 10.3389/Fphar.2018.00431 |
0.698 |
|
| 2018 |
Sriram K, Moyung K, Corriden R, Insel P. Abstract 3293: Solid tumors have frequent mutation, copy number variation and differential mRNA expression of GPCRs: Are such GPCRs functional oncogenes Cancer Research. 78: 3293-3293. DOI: 10.1158/1538-7445.Am2018-3293 |
0.688 |
|
| 2017 |
Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. GPR68, a proton-sensing GPCR, mediates interaction of cancer associated fibroblasts and cancer cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29092903 DOI: 10.1096/fj.201700834R |
0.356 |
|
| 2017 |
Busija AR, Patel HH, Insel PA. Hugh Davson Distinguished Lectureship Article Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. American Journal of Physiology. Cell Physiology. ajpcell.00355.2016. PMID 28122734 DOI: 10.1152/Ajpcell.00355.2016 |
0.555 |
|
| 2017 |
Insel PA, Sriram K, Wiley SZ, McCann T, French RP, Lowy AM. Abstract 1139: G protein-coupled receptors (GPCRs): unrecognized potential therapeutic targets in cancer Cancer Research. 77: 1139-1139. DOI: 10.1158/1538-7445.Am2017-1139 |
0.373 |
|
| 2016 |
Sunahara RK, Insel PA. The molecular pharmacology of G protein signaling then and now: A tribute to Alfred G. Gilman. Molecular Pharmacology. PMID 26984025 DOI: 10.1124/Mol.116.104216 |
0.321 |
|
| 2016 |
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, ... ... Insel PA, et al. The Gq signalling pathway inhibits brown and beige adipose tissue. Nature Communications. 7: 10895. PMID 26955961 DOI: 10.1038/Ncomms10895 |
0.359 |
|
| 2016 |
Sriram K, Zhou S, Lowy AM, Insel PA. Comparative analysis of methods to profile mRNA expression of G-protein coupled receptors The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.1028.4 |
0.391 |
|
| 2015 |
Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D. Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26675706 DOI: 10.1096/Fj.15-280982 |
0.347 |
|
| 2015 |
Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proceedings of the National Academy of Sciences of the United States of America. PMID 26417071 DOI: 10.1073/Pnas.1516057112 |
0.378 |
|
| 2015 |
Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. The Journal of Biological Chemistry. 290: 22274-86. PMID 26203188 DOI: 10.1074/Jbc.M115.658153 |
0.376 |
|
| 2015 |
Walker CS, Eftekhari S, Bower RL, Wilderman A, Insel PA, Edvinsson L, Waldvogel HJ, Jamaluddin MA, Russo AF, Hay DL. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor. Annals of Clinical and Translational Neurology. 2: 595-608. PMID 26125036 DOI: 10.1002/acn3.197 |
0.362 |
|
| 2015 |
Overland AC, Insel PA. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. The Journal of Biological Chemistry. 290: 9941-7. PMID 25759388 DOI: 10.1074/Jbc.C115.647073 |
0.327 |
|
| 2015 |
Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, et al. G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets. Molecular Pharmacology. 88: 181-7. PMID 25737495 DOI: 10.1124/Mol.115.098129 |
0.811 |
|
| 2015 |
Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 112: 1529-34. PMID 25605931 DOI: 10.1073/pnas.1417972112 |
0.36 |
|
| 2015 |
Zhou S, McCann T, French R, Lowy A, Insel P. Abstract A57: GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A57 |
0.342 |
|
| 2015 |
Zhou S, French R, Lowy AM, Insel PA. Abstract A68: GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-A68 |
0.347 |
|
| 2015 |
Zhou S, Chang S, McCann T, French R, Lowy AM, Insel PA. Abstract C156: GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C156 |
0.355 |
|
| 2014 |
Brown LM, Rogers KE, Aroonsakool N, McCammon JA, Insel PA. Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors. The Journal of Biological Chemistry. 289: 29148-57. PMID 25183009 DOI: 10.1074/Jbc.M114.569319 |
0.326 |
|
| 2014 |
Insel PA, Wilderman A, Zhang L, Keshwani MM, Zambon AC. Cyclic AMP/PKA-promoted apoptosis: insights from studies of S49 lymphoma cells. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et MéTabolisme. 46: 854-62. PMID 25028794 DOI: 10.1055/S-0034-1384519 |
0.68 |
|
| 2014 |
Fridolfsson HN, Roth DM, Insel PA, Patel HH. Regulation of intracellular signaling and function by caveolin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3823-3831. PMID 24858278 DOI: 10.1096/Fj.14-252320 |
0.579 |
|
| 2014 |
Brown LM, Rogers KE, McCammon JA, Insel PA. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition. The Journal of Biological Chemistry. 289: 8217-30. PMID 24497631 DOI: 10.1074/Jbc.M114.548636 |
0.374 |
|
| 2014 |
Lu D, Insel PA. Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis. American Journal of Physiology. Cell Physiology. 306: C779-88. PMID 24352335 DOI: 10.1152/Ajpcell.00381.2013 |
0.547 |
|
| 2014 |
Head BP, Patel HH, Insel PA. Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling. Biochimica Et Biophysica Acta. 1838: 532-45. PMID 23899502 DOI: 10.1016/J.Bbamem.2013.07.018 |
0.734 |
|
| 2014 |
Wilderman A, Guo Y, Taylor S, Insel P. cAMP/PKA-mediated regulation of amino acid metabolism in murine T-lymphoma cells (1095.16) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1095.16 |
0.384 |
|
| 2013 |
Lu D, Aroonsakool N, Yokoyama U, Patel HH, Insel PA. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Molecular Pharmacology. 84: 787-93. PMID 24085841 DOI: 10.1124/Mol.113.087742 |
0.682 |
|
| 2013 |
Lu D, Insel PA. Hydrolysis of extracellular ATP by ectonucleoside triphosphate diphosphohydrolase (ENTPD) establishes the set point for fibrotic activity of cardiac fibroblasts. The Journal of Biological Chemistry. 288: 19040-9. PMID 23677997 DOI: 10.1074/Jbc.M113.466102 |
0.555 |
|
| 2013 |
Murray F, Insel PA. Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma. Expert Opinion On Therapeutic Targets. 17: 937-49. PMID 23647244 DOI: 10.1517/14728222.2013.798304 |
0.382 |
|
| 2013 |
Insel PA, Fuhs SR, Busija A, Roth DM, Patel HH. β-Adrenergic Receptors, Caveolae and Caveolins: Receptor Localization and Function Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 107. DOI: 10.1016/B978-0-12-800044-1.00093-3 |
0.794 |
|
| 2012 |
Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 51: 9323-32. PMID 23110364 DOI: 10.1021/Bi301282K |
0.378 |
|
| 2012 |
Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, ... ... Insel PA, et al. Mitochondria-localized caveolin in adaptation to cellular stress and injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4637-49. PMID 22859372 DOI: 10.1096/Fj.12-215798 |
0.693 |
|
| 2012 |
Snead AN, Insel PA. Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4540-7. PMID 22859370 DOI: 10.1096/fj.12-213496 |
0.425 |
|
| 2012 |
Michel MC, Insel PA. Can you blame cold feet on Epac (and Rap1A)? Focus on "cyclic AMP-Rap1A signaling activates RhoA to induce α(2C)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells". American Journal of Physiology. Cell Physiology. 303: C488-9. PMID 22814395 DOI: 10.1152/ajpcell.00238.2012 |
0.378 |
|
| 2012 |
Rana BK, Bourne PE, Insel PA. Receptor databases and computational websites for ligand binding. Methods in Molecular Biology (Clifton, N.J.). 897: 1-13. PMID 22674158 DOI: 10.1007/978-1-61779-909-9_1 |
0.368 |
|
| 2012 |
Corriden R, Insel PA. New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signalling. 8: 587-98. PMID 22528684 DOI: 10.1007/S11302-012-9311-X |
0.726 |
|
| 2012 |
Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 109: E1221-9. PMID 22493239 DOI: 10.1073/Pnas.1202741109 |
0.331 |
|
| 2012 |
Burnstock G, Insel PA, Di Virgilio F. Special issue on cell and molecular biology of purinergic signalling: an introduction. Purinergic Signalling. 8: 341. PMID 22476941 DOI: 10.1007/s11302-012-9312-9 |
0.414 |
|
| 2012 |
Lu D, Soleymani S, Madakshire R, Insel PA. ATP released from cardiac fibroblasts via connexin hemichannels activates profibrotic P2Y2 receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2580-91. PMID 22415310 DOI: 10.1096/Fj.12-204677 |
0.566 |
|
| 2012 |
Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. The Journal of Clinical Investigation. 122: 963-73. PMID 22326954 DOI: 10.1172/JCI59097 |
0.31 |
|
| 2012 |
Insel PA, Murray F, Yokoyama U, Romano S, Yun H, Brown L, Snead A, Lu D, Aroonsakool N. cAMP and Epac in the regulation of tissue fibrosis. British Journal of Pharmacology. 166: 447-56. PMID 22233238 DOI: 10.1111/J.1476-5381.2012.01847.X |
0.521 |
|
| 2012 |
Insel PA, Snead A, Murray F, Zhang L, Yokouchi H, Katakia T, Kwon O, Dimucci D, Wilderman A. GPCR expression in tissues and cells: are the optimal receptors being used as drug targets? British Journal of Pharmacology. 165: 1613-6. PMID 21488863 DOI: 10.1111/j.1476-5381.2011.01434.x |
0.395 |
|
| 2012 |
Insel PA, Zhang L, Murray F, Yokouchi H, Zambon AC. Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger. Acta Physiologica (Oxford, England). 204: 277-87. PMID 21385327 DOI: 10.1111/J.1748-1716.2011.02273.X |
0.679 |
|
| 2011 |
Insel PA. β(2)-Adrenergic receptor polymorphisms and signaling: Do variants influence the "memory" of receptor activation? Science Signaling. 4: pe37. PMID 21868355 DOI: 10.1126/scisignal.2002352 |
0.409 |
|
| 2011 |
Zambon AC, Wilderman A, Ho A, Insel PA. Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells. The Journal of Biological Chemistry. 286: 33260-7. PMID 21808067 DOI: 10.1074/Jbc.M111.268979 |
0.679 |
|
| 2011 |
Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. The Journal of Biological Chemistry. 286: 33310-21. PMID 21799010 DOI: 10.1074/Jbc.M111.255976 |
0.713 |
|
| 2011 |
Creighton J, Jian M, Sayner S, Alexeyev M, Insel PA. Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3356-65. PMID 21680893 DOI: 10.1096/fj.10-179218 |
0.389 |
|
| 2011 |
Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel PA. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cellular Signalling. 23: 1611-6. PMID 21620962 DOI: 10.1016/J.Cellsig.2011.05.014 |
0.361 |
|
| 2011 |
Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. Journal of the American College of Cardiology. 57: 2273-83. PMID 21616289 DOI: 10.1016/J.Jacc.2010.12.032 |
0.781 |
|
| 2011 |
Rieg T, Gerasimova M, Boyer JL, Insel PA, Vallon V. P2Y₂ receptor activation decreases blood pressure and increases renal Na⺠excretion. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R510-8. PMID 21613580 DOI: 10.1152/ajpregu.00148.2011 |
0.344 |
|
| 2011 |
Fuhs SR, Insel PA. Caveolin-3 undergoes SUMOylation by the SUMO E3 ligase PIASy: sumoylation affects G-protein-coupled receptor desensitization. The Journal of Biological Chemistry. 286: 14830-41. PMID 21362625 DOI: 10.1074/Jbc.M110.214270 |
0.806 |
|
| 2010 |
Rieg T, Tang T, Murray F, Schroth J, Insel PA, Fenton RA, Hammond HK, Vallon V. Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medulla. Journal of the American Society of Nephrology : Jasn. 21: 2059-68. PMID 20864687 DOI: 10.1681/ASN.2010040409 |
0.331 |
|
| 2010 |
Stockand JD, Mironova E, Bugaj V, Rieg T, Insel PA, Vallon V, Peti-Peterdi J, Pochynyuk O. Purinergic inhibition of ENaC produces aldosterone escape. Journal of the American Society of Nephrology : Jasn. 21: 1903-11. PMID 20813869 DOI: 10.1681/Asn.2010040377 |
0.305 |
|
| 2010 |
Woehrle T, Yip L, Elkhal A, Sumi Y, Chen Y, Yao Y, Insel PA, Junger WG. Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse Blood. 116: 3475-3484. PMID 20660288 DOI: 10.1182/Blood-2010-04-277707 |
0.391 |
|
| 2010 |
Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. The Journal of Biological Chemistry. 285: 27632-40. PMID 20581396 DOI: 10.1074/Jbc.M110.146589 |
0.574 |
|
| 2010 |
Braun OO, Lu D, Aroonsakool N, Insel PA. Uridine triphosphate (UTP) induces profibrotic responses in cardiac fibroblasts by activation of P2Y2 receptors Journal of Molecular and Cellular Cardiology. 49: 362-369. PMID 20471392 DOI: 10.1016/J.Yjmcc.2010.05.001 |
0.581 |
|
| 2010 |
Choi LJ, Jenikova G, Hanson E, Spehlmann ME, Boehling NS, Kirstein SL, Bundey RA, Smith JR, Insel PA, Eckmann L. Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G Protein (Gs) in intestinal epithelial cell differentiation Journal of Biological Chemistry. 285: 12504-12511. PMID 20157112 DOI: 10.1074/jbc.M109.059741 |
0.384 |
|
| 2010 |
Pochynyuk O, Rieg T, Bugaj V, Schroth J, Fridman A, Boss GR, Insel PA, Stockand JD, Vallon V. Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone Faseb Journal. 24: 2056-2065. PMID 20097874 DOI: 10.1096/fj.09-151506 |
0.343 |
|
| 2010 |
Corriden R, Insel PA. Basal release of ATP: An autocrine-paracrine mechanism for cell regulation Science Signaling. 3: re1. PMID 20068232 DOI: 10.1126/Scisignal.3104Re1 |
0.735 |
|
| 2010 |
Zhang L, Hwang X, Insel PA. Abstract 1213: Cytotoxic T lymphocyte antigen-2 alpha (CTLA-2α) induces apoptosis in lymphoma cells and is regulated by the cAMP/PKA signaling pathway Cancer Research. 70: 1213-1213. DOI: 10.1158/1538-7445.Am10-1213 |
0.379 |
|
| 2010 |
Delpire E, Insel PA. AJP-Cell Physiology initiates publication of the Hugh Davson distinguished lecture American Journal of Physiology - Cell Physiology. 299: C875. DOI: 10.1152/ajpcell.00339.2010 |
0.304 |
|
| 2009 |
Yip L, Woehrle T, Corriden R, Hirsh M, Chen Y, Inoue Y, Ferrari V, Insel PA, Junger WG. Autocrine regulation of T-cell activation by ATP release and P2X7 receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1685-93. PMID 19211924 DOI: 10.1096/Fj.08-126458 |
0.741 |
|
| 2009 |
Insel PA, Patel HH. Membrane rafts and caveolae in cardiovascular signaling Current Opinion in Nephrology and Hypertension. 18: 50-56. PMID 19077689 DOI: 10.1097/Mnh.0B013E3283186F82 |
0.592 |
|
| 2009 |
Dong X, Smoll EJ, Ko KH, Lee J, Chow JY, Kim HD, Insel PA, Dong H. P2Y receptors mediate Ca 2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion American Journal of Physiology - Gastrointestinal and Liver Physiology. 296: G424-G432. PMID 19074643 DOI: 10.1152/Ajpgi.90314.2008 |
0.334 |
|
| 2009 |
Patel HH, Insel PA. Lipid rafts and caveolae and their role in compartmentation of redox signaling Antioxidants and Redox Signaling. 11: 1357-1372. PMID 19061440 DOI: 10.1089/Ars.2008.2365 |
0.595 |
|
| 2008 |
Zhang L, Murray F, Zahno A, Kanter JR, Chou D, Suda R, Fenlon M, Rassenti L, Cottam H, Kipps TJ, Insel PA. Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia Proceedings of the National Academy of Sciences of the United States of America. 105: 19532-19537. PMID 19033455 DOI: 10.1073/pnas.0806152105 |
0.342 |
|
| 2008 |
Pochynyuk O, Bugaj V, Rieg T, Insel PA, Mironova E, Vallon V, Stockand JD. Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone Journal of Biological Chemistry. 283: 36599-36607. PMID 18981175 DOI: 10.1074/jbc.M807129200 |
0.417 |
|
| 2008 |
Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning Circulation. 118: 1979-1988. PMID 18936328 DOI: 10.1161/Circulationaha.108.788331 |
0.782 |
|
| 2008 |
Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine Journal of Biological Chemistry. 283: 28480-28486. PMID 18713747 DOI: 10.1074/Jbc.M800039200 |
0.708 |
|
| 2008 |
Patel HH, Murray F, Insel PA. G-Protein-coupled receptor-signaling components in membrane raft and caveolae microdomains Handbook of Experimental Pharmacology. 186: 167-184. PMID 18491052 DOI: 10.1007/978-3-540-72843-6_7 |
0.581 |
|
| 2008 |
Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals. Proceedings of the National Academy of Sciences of the United States of America. 105: 6386-91. PMID 18434542 DOI: 10.1073/Pnas.0801490105 |
0.608 |
|
| 2008 |
Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JXJ. Regulation of pulmonary vasoconstriction by agonists and caveolae Experimental Lung Research. 34: 195-208. PMID 18432456 DOI: 10.1080/01902140801925471 |
0.547 |
|
| 2008 |
Horikawa YT, Patel HH, Tsutsumi YM, Jennings MM, Kidd MW, Hagiwara Y, Ishikawa Y, Insel PA, Roth DM. Caveolin-3 expression and caveolae are required for isoflurane-induced cardiac protection from hypoxia and ischemia/reperfusion injury Journal of Molecular and Cellular Cardiology. 44: 123-130. PMID 18054955 DOI: 10.1016/J.Yjmcc.2007.10.003 |
0.754 |
|
| 2008 |
Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. The Journal of Biological Chemistry. 283: 4304-13. PMID 18048352 DOI: 10.1074/Jbc.M708673200 |
0.678 |
|
| 2008 |
Patel HH, Murray F, Insel PA. Caveolae as organizers of pharmacologically relevant signal transduction molecules Annual Review of Pharmacology and Toxicology. 48: 359-391. PMID 17914930 DOI: 10.1146/Annurev.Pharmtox.48.121506.124841 |
0.609 |
|
| 2008 |
Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond JC, Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 828-40. PMID 17905724 DOI: 10.1096/Fj.07-9299Com |
0.723 |
|
| 2007 |
Swaney JS, Patel HH, Yokoyama U, Lai NC, Spellman M, Insel PA, Roth DM. Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction American Journal of Physiology - Heart and Circulatory Physiology. 293: H3216-H3220. PMID 17873016 DOI: 10.1152/Ajpheart.00739.2007 |
0.784 |
|
| 2007 |
Insel PA. British paharmacology society 2nd focused meeting on cell signalling: GPCRs have summy days in springtime Leicester: 15-17 April, 2007, Leicester, UK Expert Opinion On Therapeutic Targets. 11: 1251-1253. PMID 17845149 DOI: 10.1517/14728222.11.9.1251 |
0.428 |
|
| 2007 |
Corriden R, Insel PA, Junger WG. A novel method using fluorescence microscopy for real-time assessment of ATP release from individual cells American Journal of Physiology - Cell Physiology. 293: C1420-C1425. PMID 17699635 DOI: 10.1152/Ajpcell.00271.2007 |
0.694 |
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| 2007 |
Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V. Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption Faseb Journal. 21: 3717-3726. PMID 17575258 DOI: 10.1096/fj.07-8807com |
0.339 |
|
| 2007 |
Steagall WK, Barrow BJ, Glasgow CG, Mendoza JW, Ehrmantraut M, Lin JP, Insel PA, Moss J. Beta-2-adrenergic receptor polymorphisms in cystic fibrosis Pharmacogenetics and Genomics. 17: 425-430. PMID 17502834 DOI: 10.1097/Fpc.0B013E3280119349 |
0.317 |
|
| 2007 |
Patel HH, Zhang S, Murray F, Suda RYS, Head BP, Yokoyama U, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti SS, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JXJ, Insel PA. Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension Faseb Journal. 21: 2970-2979. PMID 17470567 DOI: 10.1096/Fj.07-8424Com |
0.785 |
|
| 2007 |
Yip L, Cheung CW, Corriden R, Chen Y, Insel PA, Junger WG. Hypertonic stress regulates T-cell function by the opposing actions of extracellular adenosine triphosphate and adenosine Shock. 27: 242-250. PMID 17304104 DOI: 10.1097/01.Shk.0000245014.96419.3A |
0.722 |
|
| 2007 |
Patel HH, Tsutsumi YM, Head BP, Niesman IR, Jennings M, Horikawa Y, Huang D, Moreno AL, Patel PM, Insel PA, Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: A role for caveolae and caveolin-1 Faseb Journal. 21: 1565-1574. PMID 17272740 DOI: 10.1096/Fj.06-7719Com |
0.79 |
|
| 2007 |
Arthur DB, Taupenot L, Insel PA. Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release Journal of Neurochemistry. 100: 1257-1264. PMID 17241236 DOI: 10.1111/J.1471-4159.2006.04305.X |
0.723 |
|
| 2007 |
Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JXJ. Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry American Journal of Physiology - Lung Cellular and Molecular Physiology. 292: L1202-L1210. PMID 17189322 DOI: 10.1152/Ajplung.00214.2006 |
0.59 |
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| 2007 |
Insel PA, Patel HH. Do studies in caveolin-knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for 'lost proteins'? British Journal of Pharmacology. 150: 251-254. PMID 17179949 DOI: 10.1038/Sj.Bjp.0706981 |
0.575 |
|
| 2007 |
Head BP, Insel PA. Do caveolins regulate cells by actions outside of caveolae? Trends in Cell Biology. 17: 51-57. PMID 17150359 DOI: 10.1016/J.Tcb.2006.11.008 |
0.644 |
|
| 2007 |
Insel PA, Tang CM, Hahntow I, Michel MC. Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets Biochimica Et Biophysica Acta - Biomembranes. 1768: 994-1005. PMID 17081496 DOI: 10.1016/j.bbamem.2006.09.029 |
0.329 |
|
| 2007 |
Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, Insel PA. Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L294-303. PMID 16980375 DOI: 10.1152/Ajplung.00190.2006 |
0.566 |
|
| 2007 |
Fuhs SR, Bundey RA, Ling Z, Insel PA. Stoichiometry of GPCR‐Gq/11 signaling components in MDCK cells: Are there “spare receptors”? The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A425-A |
0.778 |
|
| 2006 |
Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (New York, N.Y.). 314: 1792-5. PMID 17170310 DOI: 10.1126/Science.1132559 |
0.762 |
|
| 2006 |
Akimova OA, Grygorczyk A, Bundey RA, Bourcier N, Gekle M, Insel PA, Orlov SN. Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms. The Journal of Biological Chemistry. 281: 31317-25. PMID 16916802 DOI: 10.1074/Jbc.M602117200 |
0.421 |
|
| 2006 |
Bundey RA, Insel PA. Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function. Molecular Pharmacology. 70: 1700-7. PMID 16885208 DOI: 10.1124/mol.106.028035 |
0.393 |
|
| 2006 |
Ostrom RS, Insel PA. Methods for the study of signaling molecules in membrane lipid rafts and caveolae. Methods in Molecular Biology (Clifton, N.J.). 332: 181-91. PMID 16878693 DOI: 10.1385/1-59745-048-0:181 |
0.301 |
|
| 2006 |
Arthur DB, Akassoglou K, Insel PA. P2Y2 and TrkA receptors interact with Src family kinase for neuronal differentiation. Biochemical and Biophysical Research Communications. 347: 678-82. PMID 16842754 DOI: 10.1016/J.Bbrc.2006.06.141 |
0.709 |
|
| 2006 |
Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. The Journal of Biological Chemistry. 281: 26391-9. PMID 16818493 DOI: 10.1074/Jbc.M602577200 |
0.803 |
|
| 2006 |
Swaney JS, Patel HH, Yokoyama U, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. The Journal of Biological Chemistry. 281: 17173-9. PMID 16618703 DOI: 10.1074/Jbc.M513097200 |
0.793 |
|
| 2006 |
Arthur DB, Georgi S, Akassoglou K, Insel PA. Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3798-804. PMID 16597733 DOI: 10.1523/Jneurosci.5338-05.2006 |
0.712 |
|
| 2006 |
Patel HH, Head BP, Petersen HN, Niesman IR, Huang D, Gross GJ, Insel PA, Roth DM. Protection of adult rat cardiac myocytes from ischemic cell death: role of caveolar microdomains and delta-opioid receptors. American Journal of Physiology. Heart and Circulatory Physiology. 291: H344-50. PMID 16501018 DOI: 10.1152/Ajpheart.01100.2005 |
0.729 |
|
| 2006 |
Büscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenetics and Genomics. 16: 199-205. PMID 16495779 DOI: 10.1097/01.Fpc.0000189798.11468.6A |
0.758 |
|
| 2006 |
Riddle EL, Rana BK, Murthy KK, Rao F, Eskin E, O'Connor DT, Insel PA. Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives. Hypertension. 47: 415-20. PMID 16432041 DOI: 10.1161/01.Hyp.0000200714.81990.61 |
0.316 |
|
| 2006 |
Zhang L, Murray F, Kanter JR, Chou D, Rassenti L, Kipps TJ, Insel PA. Chronic Lymphocytic Leukemia Cells Have Increased Expression of Cyclic Nucleotide Phosphodiesterase 7B, Which May Serve as Disease-Specific Therapeutic Target. Blood. 108: 2802-2802. DOI: 10.1182/blood.v108.11.2802.2802 |
0.328 |
|
| 2006 |
Chen Y, Yip L, Corriden R, Insel PA, Junger WG. CELL SURFACE EXPRESSION OF A3 AND A2A ADENOSINE RECEPTORS DEFINES THE RESPONSE OF PMN TO HYPERTONIC SALINE Shock. 26: 29. DOI: 10.1097/00024382-200610001-00089 |
0.715 |
|
| 2006 |
Chen Y, Corriden R, Yip L, Inoue Y, Insel P, Junger WG. CONTROL OF PMN CHEMOTAXIS BY AUTOCRINE FEEDBACK THROUGH PURINERGIC RECEPTORS Shock. 26: 18. DOI: 10.1097/00024382-200610001-00055 |
0.706 |
|
| 2006 |
Yip L, Cheung C, Chen Y, Corriden R, Hashiguchi N, Insel PA, Junger WG. MODULATION OF T CELL FUNCTION BY ATP, ADENOSINE, AND P1/P2 RECEPTORS Shock. 26: 17. DOI: 10.1097/00024382-200610001-00053 |
0.707 |
|
| 2005 |
Arthur DB, Akassoglou K, Insel PA. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America. 102: 19138-43. PMID 16365320 DOI: 10.1073/Pnas.0505913102 |
0.71 |
|
| 2005 |
Tang CM, Insel PA. Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets. Expert Opinion On Therapeutic Targets. 9: 1247-65. PMID 16300474 DOI: 10.1517/14728222.9.6.1247 |
0.386 |
|
| 2005 |
Insel PA, Head BP, Patel HH, Roth DM, Bundey RA, Swaney JS. Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae. Biochemical Society Transactions. 33: 1131-4. PMID 16246064 DOI: 10.1042/Bst0331131 |
0.802 |
|
| 2005 |
Akimova AO, Bourcier N, Taurin S, Bundey RA, Grygorczyk K, Gekle M, Insel PA, Dulin NO, Orlov SN. Cl- secretion in ATP-treated renal epithelial C7-MDCK cells is mediated by activation of P 2Y1 receptors, phospholipase A2 and protein kinase A. The Journal of Physiology. 568: 789-801. PMID 16109726 DOI: 10.1113/Jphysiol.2005.094375 |
0.406 |
|
| 2005 |
Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Annals of the New York Academy of Sciences. 1047: 166-72. PMID 16093494 DOI: 10.1196/Annals.1341.015 |
0.805 |
|
| 2005 |
Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. The Journal of Biological Chemistry. 280: 31036-44. PMID 15961389 DOI: 10.1074/Jbc.M502540200 |
0.752 |
|
| 2005 |
Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 102: 8561-6. PMID 15939874 DOI: 10.1073/Pnas.0503363102 |
0.673 |
|
| 2005 |
King D, Etzel JP, Chopra S, Smith J, Cadman PE, Rao F, Funk SD, Rana BK, Schork NJ, Insel PA, O'Connor DT. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. Clinical Pharmacology and Therapeutics. 77: 388-403. PMID 15900285 DOI: 10.1016/j.clpt.2005.02.008 |
0.316 |
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| 2005 |
Riddle EL, Schwartzman RA, Bond M, Insel PA. Multi-tasking RGS proteins in the heart: the next therapeutic target? Circulation Research. 96: 401-11. PMID 15746448 DOI: 10.1161/01.Res.0000158287.49872.4E |
0.362 |
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| 2005 |
Swaney JS, Roth DM, Olson ER, Naugle JE, Meszaros JG, Insel PA. Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 102: 437-42. PMID 15625103 DOI: 10.1073/Pnas.0408704102 |
0.771 |
|
| 2005 |
ETZEL J, RANA B, WEN G, PARMER R, SCHORK N, OCONNOR D, INSEL P. Genetic variation in the human ?2B-ADRENERGIC receptor gene: Haplotypes and yohimbine response Clinical Pharmacology & Therapeutics. 77: P7-P7. DOI: 10.1016/J.Clpt.2004.11.028 |
0.304 |
|
| 2004 |
Ostrom RS, Insel PA. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. British Journal of Pharmacology. 143: 235-45. PMID 15289291 DOI: 10.1038/sj.bjp.0705930 |
0.435 |
|
| 2004 |
Bundey RA, Insel PA. Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP? Science's Stke : Signal Transduction Knowledge Environment. 2004: pe19. PMID 15126677 DOI: 10.1126/stke.2312004pe19 |
0.355 |
|
| 2004 |
Tang CM, Insel PA. GPCR expression in the heart; "new" receptors in myocytes and fibroblasts. Trends in Cardiovascular Medicine. 14: 94-9. PMID 15121156 DOI: 10.1016/j.tcm.2003.12.007 |
0.453 |
|
| 2004 |
Chen Y, Shukla A, Namiki S, Insel PA, Junger WG. A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors. Journal of Leukocyte Biology. 76: 245-53. PMID 15107462 DOI: 10.1189/jlb.0204066 |
0.386 |
|
| 2004 |
Nishihara H, Hwang M, Kizaka-Kondoh S, Eckmann L, Insel PA. Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. The Journal of Biological Chemistry. 279: 26176-83. PMID 15078890 DOI: 10.1074/jbc.M313346200 |
0.368 |
|
| 2004 |
Liu X, Ostrom RS, Insel PA. cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. American Journal of Physiology. Cell Physiology. 286: C1089-99. PMID 15075208 DOI: 10.1152/ajpcell.00461.2003 |
0.412 |
|
| 2004 |
Ostrom RS, Bundey RA, Insel PA. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. The Journal of Biological Chemistry. 279: 19846-53. PMID 15007069 DOI: 10.1074/jbc.M313440200 |
0.418 |
|
| 2004 |
Kirstein SL, Insel PA. Autonomic nervous system pharmacogenomics: a progress report. Pharmacological Reviews. 56: 31-52. PMID 15001662 DOI: 10.1124/pr.56.1.2 |
0.369 |
|
| 2004 |
Zhang L, Insel PA. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. The Journal of Biological Chemistry. 279: 20858-65. PMID 14996839 DOI: 10.1074/jbc.M310643200 |
0.38 |
|
| 2003 |
Brindikova TA, Bourcier N, Torres B, Pchejetski D, Gekle M, Maximov GV, Montminy V, Insel PA, Orlov SN, Isenring P. Purinergic-induced signaling in C11-MDCK cells inhibits the secretory Na-K-Cl cotransporter. American Journal of Physiology. Cell Physiology. 285: C1445-53. PMID 12917108 DOI: 10.1152/Ajpcell.00386.2002 |
0.337 |
|
| 2003 |
Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 8921-6. PMID 12837940 DOI: 10.1073/pnas.1533221100 |
0.392 |
|
| 2003 |
Insel PA, Ostrom RS. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cellular and Molecular Neurobiology. 23: 305-14. PMID 12825829 DOI: 10.1023/A:1023684503883 |
0.439 |
|
| 2003 |
Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. The Journal of Biological Chemistry. 278: 24461-8. PMID 12711600 DOI: 10.1074/Jbc.M212659200 |
0.771 |
|
| 2003 |
Lee A, Rana BK, Schiffer HH, Schork NJ, Brann MR, Insel PA, Weiner DM. Distribution analysis of nonsynonymous polymorphisms within the G-protein-coupled receptor gene family. Genomics. 81: 245-8. PMID 12659808 DOI: 10.1016/S0888-7543(03)00009-0 |
0.328 |
|
| 2003 |
Patel HH, Fryer RM, Gross ER, Bundey RA, Hsu AK, Isbell M, Eusebi LO, Jensen RV, Gullans SR, Insel PA, Nithipatikom K, Gross GJ. 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. Circulation Research. 92: 676-82. PMID 12623876 DOI: 10.1161/01.Res.0000065167.52922.F6 |
0.539 |
|
| 2003 |
Michel MC, Insel PA. Receptor gene polymorphisms: lessons on functional relevance from the beta 1-adrenoceptor. British Journal of Pharmacology. 138: 279-82. PMID 12540516 DOI: 10.1038/sj.bjp.0705031 |
0.33 |
|
| 2003 |
Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG. Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation. The Journal of Biological Chemistry. 278: 4590-6. PMID 12464620 DOI: 10.1074/jbc.M207868200 |
0.37 |
|
| 2003 |
Hughes RJ, Torres B, Zambon A, Arthur D, Bohmann C, Rump LC, Insel PA. Expression of multiple P2Y receptors by MDCK-D1 cells: P2Y1 receptor cloning and signaling Drug Development Research. 59: 1-7. DOI: 10.1002/Ddr.10196 |
0.815 |
|
| 2002 |
Rana BK, Insel PA. G-protein-coupled receptor websites. Trends in Pharmacological Sciences. 23: 535-6. PMID 12413809 DOI: 10.1016/S0165-6147(02)02113-2 |
0.355 |
|
| 2002 |
Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Molecular Pharmacology. 62: 983-92. PMID 12391260 DOI: 10.1124/Mol.62.5.983 |
0.67 |
|
| 2002 |
Torres B, Zambon AC, Insel PA. P2Y11 receptors activate adenylyl cyclase and contribute to nucleotide-promoted cAMP formation in MDCK-D(1) cells. A mechanism for nucleotide-mediated autocrine-paracrine regulation. The Journal of Biological Chemistry. 277: 7761-5. PMID 11788591 DOI: 10.1074/Jbc.M110352200 |
0.717 |
|
| 2002 |
Ostrom RS, Rana BK, Insel PA. Stoichiometry of G protein-coupled receptor signaling: Implications in the genomic era Pharmaceutical News. 9: 295-303. DOI: 10.1080/10718940216630 |
0.358 |
|
| 2001 |
Rana BK, Insel PA. Useful G-protein-coupled receptor websites. Trends in Pharmacological Sciences. 22: 485-6. PMID 12613478 DOI: 10.1016/S0165-6147(00)01806-X |
0.35 |
|
| 2001 |
Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science (New York, N.Y.). 294: 1939-42. PMID 11729322 DOI: 10.1126/Science.1064757 |
0.367 |
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| 2001 |
Qi AD, Zambon AC, Insel PA, Nicholas RA. An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors. Molecular Pharmacology. 60: 1375-82. PMID 11723245 DOI: 10.1124/Mol.60.6.1375 |
0.675 |
|
| 2001 |
Zhang L, Insel PA. Bcl-2 protects lymphoma cells from apoptosis but not growth arrest promoted by cAMP and dexamethasone. American Journal of Physiology. Cell Physiology. 281: C1642-7. PMID 11600428 DOI: 10.1152/Ajpcell.2001.281.5.C1642 |
0.328 |
|
| 2001 |
Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. The Journal of Biological Chemistry. 276: 42063-9. PMID 11533056 DOI: 10.1074/Jbc.M105348200 |
0.407 |
|
| 2001 |
Ostrom RS, Gregorian C, Drenan RM, Gabot K, Rana BK, Insel PA. Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP. American Journal of Physiology. Cell Physiology. 281: C524-31. PMID 11443051 DOI: 10.1152/Ajpcell.2001.281.2.C524 |
0.438 |
|
| 2001 |
Zambon AC, Brunton LL, Barrett KE, Hughes RJ, Torres B, Insel PA. Cloning, expression, signaling mechanisms, and membrane targeting of P2Y(11) receptors in Madin Darby canine kidney cells. Molecular Pharmacology. 60: 26-35. PMID 11408597 DOI: 10.1124/Mol.60.1.26 |
0.727 |
|
| 2001 |
Insel PA, Ostrom RS, Zambon AC, Hughes RJ, Balboa MA, Shehnaz D, Gregorian C, Torres B, Firestein BL, Xing M, Post SR. P2Y receptors of MDCK cells: epithelial cell regulation by extracellular nucleotides. Clinical and Experimental Pharmacology & Physiology. 28: 351-4. PMID 11339212 DOI: 10.1046/J.1440-1681.2001.03452.X |
0.831 |
|
| 2001 |
Rana BK, Shiina T, Insel PA. Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. Annual Review of Pharmacology and Toxicology. 41: 593-624. PMID 11264470 DOI: 10.1146/annurev.pharmtox.41.1.593 |
0.338 |
|
| 2001 |
Brodde OE, Büscher R, Tellkamp R, Radke J, Dhein S, Insel PA. Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors. Circulation. 103: 1048-50. PMID 11222464 DOI: 10.1161/01.CIR.103.8.1048 |
0.342 |
|
| 2000 |
Zambon AC, Hughes RJ, Meszaros JG, Wu JJ, Torres B, Brunton LL, Insel PA. P2Y(2) receptor of MDCK cells: cloning, expression, and cell-specific signaling. American Journal of Physiology. Renal Physiology. 279: F1045-52. PMID 11097622 DOI: 10.1152/Ajprenal.2000.279.6.F1045 |
0.723 |
|
| 2000 |
Yan L, Herrmann V, Hofer JK, Insel PA. beta-adrenergic receptor/cAMP-mediated signaling and apoptosis of S49 lymphoma cells. American Journal of Physiology. Cell Physiology. 279: C1665-74. PMID 11029315 DOI: 10.1152/Ajpcell.2000.279.5.C1665 |
0.39 |
|
| 2000 |
Herrmann V, Büscher R, Go MM, Ring KM, Hofer JK, Kailasam MT, O'Connor DT, Parmer RJ, Insel PA. Beta2-adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in whites and African Americans. American Journal of Hypertension. 13: 1021-6. PMID 10981553 DOI: 10.1016/S0895-7061(00)01188-2 |
0.304 |
|
| 2000 |
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616 DOI: 10.1152/Ajplung.2000.279.3.L429 |
0.383 |
|
| 2000 |
Horie K, Insel PA. Retrovirally mediated transfer of a G protein-coupled receptor kinase (GRK) dominant-negative mutant enhances endogenous calcitonin receptor signaling in Chinese hamster ovary cells. GRK inhibition enhances expression of receptors and receptor mRNA. The Journal of Biological Chemistry. 275: 29433-40. PMID 10889199 DOI: 10.1074/jbc.M003413200 |
0.425 |
|
| 2000 |
Ostrom RS, Violin JD, Coleman S, Insel PA. Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Molecular Pharmacology. 57: 1075-9. PMID 10779394 |
0.313 |
|
| 2000 |
Ostrom RS, Gregorian C, Insel PA. Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways. The Journal of Biological Chemistry. 275: 11735-9. PMID 10766795 DOI: 10.1074/jbc.275.16.11735 |
0.4 |
|
| 2000 |
Shehnaz D, Torres B, Balboa MA, Insel PA. Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a putative P2Y(1) receptor antagonist, blocks signaling at a site distal to the receptor in Madin-Darby canine kidney-D(1) cells. The Journal of Pharmacology and Experimental Therapeutics. 292: 346-50. PMID 10604969 |
0.318 |
|
| 1999 |
Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospholipase A2. Annual Review of Pharmacology and Toxicology. 39: 175-89. PMID 10331081 DOI: 10.1146/Annurev.Pharmtox.39.1.175 |
0.694 |
|
| 1999 |
Ostrom RS, Insel PA. Caveolar microdomains of the sarcolemma: compartmentation of signaling molecules comes of age. Circulation Research. 84: 1110-2. PMID 10325248 DOI: 10.1161/01.RES.84.9.1110 |
0.42 |
|
| 1999 |
Xing M, Post S, Ostrom RS, Samardzija M, Insel PA. Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells. The Journal of Biological Chemistry. 274: 10035-8. PMID 10187781 DOI: 10.1074/Jbc.274.15.10035 |
0.468 |
|
| 1998 |
Büscher R, Herrmann V, Insel PA. PCR-based methods for identifying genetic variations in human alpha1B- and beta2-adrenergic receptors. Molecular Genetics and Metabolism. 64: 266-70. PMID 9758717 DOI: 10.1006/mgme.1998.2719 |
0.376 |
|
| 1998 |
Post SR, Rump LC, Zambon A, Hughes RJ, Buda MD, Jacobson JP, Kao CC, Insel PA. ATP activates cAMP production via multiple purinergic receptors in MDCK-D1 epithelial cells. Blockade of an autocrine/paracrine pathway to define receptor preference of an agonist. The Journal of Biological Chemistry. 273: 23093-7. PMID 9722536 DOI: 10.1074/Jbc.273.36.23093 |
0.716 |
|
| 1998 |
Balboa MA, Insel PA. Stimulation of phospholipase D via alpha1-adrenergic receptors in Madin-Darby canine kidney cells is independent of PKCalpha and -epsilon activation. Molecular Pharmacology. 53: 221-7. PMID 9463479 DOI: 10.1124/Mol.53.2.221 |
0.683 |
|
| 1998 |
Gao M, Ping P, Post S, Insel PA, Tang R, Hammond HK. Increased expression of adenylylcyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 95: 1038-43. PMID 9448281 DOI: 10.1073/Pnas.95.3.1038 |
0.441 |
|
| 1998 |
Hammond HK, Ping P, Insel PA. Cardiac G-protein receptor kinase activity: effect of a beta-adrenergic receptor antagonist. Advances in Pharmacology (San Diego, Calif.). 42: 507-10. PMID 9327951 DOI: 10.1016/S1054-3589(08)60800-5 |
0.383 |
|
| 1998 |
Insel PA, Balboa MA, Mochizuki N, Post SR, Urasawa K, Xing M. Mechanisms for activation of multiple effectors by alpha 1-adrenergic receptors. Advances in Pharmacology (San Diego, Calif.). 42: 451-3. PMID 9327936 DOI: 10.1016/S1054-3589(08)60785-1 |
0.661 |
|
| 1998 |
Herrmann V, Büscher R, Ring KM, Kailasam MT, O'Connor DT, Parmer RJ, Insel PA. H010 Association of essential hypertension with polymorphisms in the β2-adrenergic receptor American Journal of Hypertension. 11. DOI: 10.1016/S0895-7061(97)91318-2 |
0.307 |
|
| 1997 |
Hughes RJ, Pasillas M, Saiz J, Jasper J, Insel PA. Decreased transcript expression coincident with impaired glycosylation in the beta2-adrenergic receptor gene does not result from differences in the primary sequence. Biochimica Et Biophysica Acta. 1356: 281-91. PMID 9194571 DOI: 10.1016/S0167-4889(97)00005-0 |
0.39 |
|
| 1997 |
Xing M, Tao L, Insel PA. Role of extracellular signal-regulated kinase and PKC alpha in cytosolic PLA2 activation by bradykinin in MDCK-D1 cells. The American Journal of Physiology. 272: C1380-7. PMID 9142865 DOI: 10.1152/Ajpcell.1997.272.4.C1380 |
0.414 |
|
| 1997 |
Xing M, Firestein BL, Shen GH, Insel PA. Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P2U receptors in MDCK-D1 cells: involvement of MAP kinase-dependent and -independent pathways. The Journal of Clinical Investigation. 99: 805-14. PMID 9045886 DOI: 10.1172/JCI119227 |
0.651 |
|
| 1997 |
Balsinde J, Balboa MA, Insel PA, Dennis EA. Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages. The Biochemical Journal. 321: 805-9. PMID 9032469 DOI: 10.1042/Bj3210805 |
0.697 |
|
| 1996 |
Insel PA, Firestein BL, Xing M, Post SR, Jacobson JP, Balboa MA, Hughes RJ. P2-purinoceptors utilize multiple signalling pathways in MDCK-D1 cells. Journal of Autonomic Pharmacology. 16: 311-3. PMID 9131405 DOI: 10.1111/J.1474-8673.1996.Tb00042.X |
0.766 |
|
| 1996 |
Firestein BL, Xing M, Hughes RJ, Corvera CU, Insel PA. Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells. The American Journal of Physiology. 271: F610-8. PMID 8853423 DOI: 10.1152/Ajprenal.1996.271.3.F610 |
0.679 |
|
| 1996 |
Michel MC, Insel PA. Making sense out of antisense for the study of drug receptors. The Journal of Clinical Investigation. 98: 1074-5. PMID 8787666 DOI: 10.1172/JCI118886 |
0.317 |
|
| 1996 |
Godson C, Masliah E, Balboa MA, Ellisman MH, Insel PA. Isoform-specific redistribution of protein kinase C in living cells. Biochimica Et Biophysica Acta. 1313: 63-71. PMID 8781551 DOI: 10.1016/0167-4889(96)00050-X |
0.635 |
|
| 1996 |
Hughes RJ, Anderson KL, Kiel D, Insel PA. Cloning of GRK2 cDNA from S49 murine lymphoma cells. The American Journal of Physiology. 270: C885-91. PMID 8638670 DOI: 10.1152/Ajpcell.1996.270.3.C885 |
0.366 |
|
| 1996 |
Xing M, Insel PA. Protein kinase C-dependent activation of cytosolic phospholipase A2 and mitogen-activated protein kinase by alpha 1-adrenergic receptors in Madin-Darby canine kidney cells. The Journal of Clinical Investigation. 97: 1302-10. PMID 8636443 DOI: 10.1172/JCI118546 |
0.431 |
|
| 1996 |
Insel PA. Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors--evolving concepts and clinical implications. The New England Journal of Medicine. 334: 580-5. PMID 8569827 DOI: 10.1056/NEJM199602293340907 |
0.329 |
|
| 1996 |
Post SR, Jacobson JP, Insel PA. P2 purinergic receptor agonists enhance cAMP production in Madin-Darby canine kidney epithelial cells via an autocrine/paracrine mechanism. The Journal of Biological Chemistry. 271: 2029-32. PMID 8567655 DOI: 10.1074/Jbc.271.4.2029 |
0.455 |
|
| 1996 |
Post SR, Aguila-Buhain O, Insel PA. A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells. The Journal of Biological Chemistry. 271: 895-900. PMID 8557702 DOI: 10.1074/Jbc.271.2.895 |
0.404 |
|
| 1995 |
Balboa MA, Insel PA. Nuclear phospholipase D in Madin-Darby canine kidney cells. Guanosine 5'-O-(thiotriphosphate)-stimulated activation is mediated by RhoA and is downstream of protein kinase C. The Journal of Biological Chemistry. 270: 29843-7. PMID 8530380 DOI: 10.1074/Jbc.270.50.29843 |
0.642 |
|
| 1995 |
Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK. Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. The Journal of Clinical Investigation. 95: 1271-80. PMID 7883975 DOI: 10.1172/Jci117777 |
0.412 |
|
| 1995 |
Mochizuki N, Urasawa K, Sanchez A, Insel PA. Developmental regulation of the alpha-subunit of Gq/G11 as determined by quantitative immunoblot analysis. Biochemical and Biophysical Research Communications. 210: 246-52. PMID 7755597 DOI: 10.1006/bbrc.1995.1653 |
0.306 |
|
| 1995 |
Jasper JR, Post SR, Desai KH, Insel PA, Bernstein D. Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions. The Journal of Pharmacology and Experimental Therapeutics. 274: 937-42. PMID 7636757 |
0.315 |
|
| 1995 |
Mochizuki N, Hibi M, Kanai Y, Insel PA. Interaction of the protein nucleobindin with G alpha i2, as revealed by the yeast two-hybrid system. Febs Letters. 373: 155-8. PMID 7589456 DOI: 10.1016/0014-5793(95)01031-9 |
0.352 |
|
| 1995 |
Post SR, Hilal-Dandan R, Urasawa K, Brunton LL, Insel PA. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. The Biochemical Journal. 311: 75-80. PMID 7575483 DOI: 10.1042/Bj3110075 |
0.434 |
|
| 1995 |
Balboa MA, Balsinde J, Dennis EA, Insel PA. A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 11738-40. PMID 7538121 DOI: 10.1074/Jbc.270.20.11738 |
0.706 |
|
| 1994 |
Balboa MA, Firestein BL, Godson C, Bell KS, Insel PA. Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2. The Journal of Biological Chemistry. 269: 10511-6. PMID 8144636 |
0.603 |
|
| 1993 |
Insel PA. Adrenergic receptors, G proteins, and cell regulation: implications for aging research. Experimental Gerontology. 28: 341-8. PMID 8224033 DOI: 10.1016/0531-5565(93)90061-H |
0.395 |
|
| 1992 |
Insel PA. GTP-binding proteins and post-receptor components in hypertension. Pharmacology & Toxicology. 70: S28-31. PMID 1380710 DOI: 10.1111/J.1600-0773.1992.Tb01619.X |
0.377 |
|
| 1992 |
Jasper JR, Insel PA. Evolving concepts of partial agonism. The beta-adrenergic receptor as a paradigm. Biochemical Pharmacology. 43: 119-30. PMID 1346741 DOI: 10.1016/0006-2952(92)90268-N |
0.418 |
|
| 1992 |
Svoboda P, Kvapil P, Insel PA, Ransnäs LA. Plasma-membrane-independent pool of the alpha subunit of the stimulatory guanine-nucleotide-binding regulatory protein in a low-density-membrane fraction of S49 lymphoma cells. European Journal of Biochemistry / Febs. 208: 693-8. PMID 1327765 DOI: 10.1111/J.1432-1033.1992.Tb17236.X |
0.322 |
|
| 1992 |
Ransnäs LA, Jasper JR, Leiber D, Insel PA. Beta-adrenergic-receptor-mediated dissociation and membrane release of the Gs protein in S49 lymphoma-cell membranes. Dependence on Mg2+ and GTP. The Biochemical Journal. 283: 519-24. PMID 1315517 DOI: 10.1042/Bj2830519 |
0.337 |
|
| 1992 |
Hammond HK, Roth DA, Insel PA, Ford CE, White FC, Maisel AS, Ziegler MG, Bloor CM. Myocardial beta-adrenergic receptor expression and signal transduction after chronic volume-overload hypertrophy and circulatory congestion. Circulation. 85: 269-80. PMID 1309445 DOI: 10.1161/01.Cir.85.1.269 |
0.364 |
|
| 1991 |
Jasper JR, Michel MC, Insel PA. Partial agonistic activity of two irreversible beta-adrenergic receptor ligands, bromoacetylated derivatives of alprenolol and pindolol. Biochemical Pharmacology. 42: S212-4. PMID 1685084 DOI: 10.1016/0006-2952(91)90412-X |
0.381 |
|
| 1991 |
Ransnäs LA, Leiber D, Insel PA. Inhibition of subunit dissociation and release of the stimulatory G-protein, Gs, by beta gamma-subunits and somatostatin in S49 lymphoma cell membranes. The Biochemical Journal. 280: 303-7. PMID 1684100 DOI: 10.1042/Bj2800303 |
0.362 |
|
| 1991 |
Insel PA, Weiss BA, Slivka SR, Howard MJ, Waite JJ, Godson CA. Regulation of phospholipase A2 by receptors in MDCK-Dl cells. Biochemical Society Transactions. 19: 329-33. PMID 1653734 DOI: 10.1042/Bst0190329 |
0.364 |
|
| 1991 |
Alousi AA, Jasper JR, Insel PA, Motulsky HJ. Stoichiometry of receptor-Gs-adenylate cyclase interactions. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2300-3. PMID 1650314 DOI: 10.1096/Fasebj.5.9.1650314 |
0.37 |
|
| 1990 |
Slivka SR, Godson C, Insel PA. ras-transformation of MDCK cells alters responses to phorbol ester without altering responses to bradykinin. Journal of Cellular Biochemistry. 42: 59-70. PMID 2407742 DOI: 10.1002/jcb.240420202 |
0.311 |
|
| 1990 |
Insel PA, Wasserman SI. Asthma: a disorder of adrenergic receptors? Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 2732-6. PMID 2197153 DOI: 10.1096/Fasebj.4.10.2197153 |
0.329 |
|
| 1990 |
Jasper JR, Michel MC, Insel PA. The beta-adrenoceptor antagonist carteolol and its metabolite 8-hydroxycarteolol have different intrinsic sympathomimetic activities. British Journal of Clinical Pharmacology. 30: 109S-111S. PMID 2176514 DOI: 10.1111/J.1365-2125.1990.Tb05477.X |
0.306 |
|
| 1990 |
Waite JJ, Insel PA. G-protein linked polyphosphoinositide phospholipase C activity in cell membranes from clonally derived and ras-transformed Madin-Darby canine kidney cells. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 68: 1119-27. PMID 2175200 DOI: 10.1139/O90-167 |
0.331 |
|
| 1990 |
Howard MJ, Insel PA. Elevated extracellular K+ enhances arachidonic acid release in MDCK-D1 cells. The American Journal of Physiology. 259: C224-31. PMID 2166433 DOI: 10.1152/Ajpcell.1990.259.2.C224 |
0.405 |
|
| 1990 |
Michel MC, Brodde OE, Insel PA. Peripheral adrenergic receptors in hypertension. Hypertension. 16: 107-20. PMID 2166000 DOI: 10.1161/01.Hyp.16.2.107 |
0.381 |
|
| 1990 |
Maisel AS, Michel MC, Insel PA, Ennis C, Ziegler MG, Phillips C. Pertussis toxin treatment of whole blood. A novel approach to assess G protein function in congestive heart failure. Circulation. 81: 1198-204. PMID 2156637 DOI: 10.1161/01.Cir.81.4.1198 |
0.306 |
|
| 1990 |
Jasper JR, Motulsky HJ, Mahan LC, Insel PA. Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells. The American Journal of Physiology. 259: C41-6. PMID 1973600 DOI: 10.1152/Ajpcell.1990.259.1.C41 |
0.434 |
|
| 1989 |
Insel PA. Adrenergic receptors. Evolving concepts on structure and function. American Journal of Hypertension. 2: 112S-118S. PMID 2647101 DOI: 10.1093/Ajh/2.3.112S |
0.383 |
|
| 1989 |
Ransnäs LA, Svoboda P, Jasper JR, Insel PA. Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes. Proceedings of the National Academy of Sciences of the United States of America. 86: 7900-3. PMID 2554294 DOI: 10.1073/Pnas.86.20.7900 |
0.344 |
|
| 1989 |
Insel PA. Structure and function of alpha-adrenergic receptors. The American Journal of Medicine. 87: 12S-18S. PMID 2548380 DOI: 10.1016/0002-9343(89)90108-3 |
0.393 |
|
| 1989 |
Michel MC, Insel PA, Brodde OE. Renal alpha-adrenergic receptor alterations: a cause of essential hypertension? Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 139-44. PMID 2536629 DOI: 10.1096/fasebj.3.2.2536629 |
0.308 |
|
| 1988 |
Insel PA. How should one study brain adrenergic receptors in aging? Neurobiology of Aging. 9: 64-6. PMID 3288894 DOI: 10.1016/S0197-4580(88)80025-3 |
0.315 |
|
| 1988 |
Jasper JR, Michel MC, Insel PA. Molecular mechanism of beta-adrenergic receptor blockers with intrinsic sympathomimetic activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2891-4. PMID 2901994 DOI: 10.1096/Fasebj.2.13.2901994 |
0.35 |
|
| 1988 |
Hughes RJ, Mahan LC, Insel PA. Certain beta-blockers can decrease beta-adrenergic receptor number: II. Down-regulation of receptor number by alprenolol and propranolol in cultured lymphoma and muscle cells. Circulation Research. 63: 279-85. PMID 2899462 DOI: 10.1161/01.RES.63.2.279 |
0.418 |
|
| 1988 |
Insel PA. Phenylalkylamines are promiscuous receptor blockers. Trends in Pharmacological Sciences. 9: 10. PMID 2854310 DOI: 10.1016/0165-6147(88)90231-3 |
0.38 |
|
| 1988 |
Hammond HK, Ransnas LA, Insel PA. Noncoordinate regulation of cardiac Gs protein and beta-adrenergic receptors by a physiological stimulus, chronic dynamic exercise. The Journal of Clinical Investigation. 82: 2168-71. PMID 2848869 DOI: 10.1172/JCI113840 |
0.396 |
|
| 1988 |
Maisel AS, Ziegler MG, Carter S, Insel PA, Motulsky HJ. In vivo regulation of beta-adrenergic receptors on mononuclear leukocytes and heart. Assessment of receptor compartmentation after agonist infusion and acute aortic constriction in guinea pigs. The Journal of Clinical Investigation. 82: 2038-44. PMID 2848867 DOI: 10.1172/JCI113824 |
0.396 |
|
| 1988 |
Terman BI, Reece JF, Brown RD, Insel PA. The oligosaccharide component of alpha 1-adrenergic receptors from BC3H1 and DDT1 muscle cells. Studies with glycosidases and photoaffinity labelling of intact cells. The Biochemical Journal. 253: 363-70. PMID 2845917 DOI: 10.1042/Bj2530363 |
0.402 |
|
| 1988 |
Slivka SR, Meier KE, Insel PA. Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C. The Journal of Biological Chemistry. 263: 12242-6. PMID 2842326 |
0.308 |
|
| 1988 |
Terman BI, Insel PA. Use of 1-deoxymannojirimycin to show that complex oligosaccharides regulate cellular distribution of the alpha 1-adrenergic receptor glycoprotein in BC3H1 muscle cells. Molecular Pharmacology. 34: 8-14. PMID 2839764 |
0.309 |
|
| 1987 |
Henry DY, Gueritte-Voegelein F, Insel PA, Ferry N, Bouguet J, Potier P, Sevenet T, Hanoune J. Isolation and characterization of 9-hydroxy-10-trans,12-cis-octadecadienoic acid, a novel regulator of platelet adenylate cyclase from Glechoma hederacea L. Labiatae. European Journal of Biochemistry / Febs. 170: 389-94. PMID 3691528 DOI: 10.1111/J.1432-1033.1987.Tb13712.X |
0.347 |
|
| 1987 |
Howard MJ, Mullen MD, Insel PA. Amiloride interacts with renal alpha- and beta-adrenergic receptors. The American Journal of Physiology. 253: F21-5. PMID 3037921 DOI: 10.1152/Ajprenal.1987.253.1.F21 |
0.367 |
|
| 1987 |
Mahan LC, McKernan RM, Insel PA. Metabolism of alpha- and beta-adrenergic receptors in vitro and in vivo. Annual Review of Pharmacology and Toxicology. 27: 215-35. PMID 3034138 DOI: 10.1146/annurev.pa.27.040187.001243 |
0.419 |
|
| 1987 |
Maisel AS, Motulsky HJ, Insel PA. Propranolol treatment externalizes beta-adrenergic receptors in guinea pig myocardium and prevents further externalization by ischemia. Circulation Research. 60: 108-12. PMID 3032472 DOI: 10.1161/01.Res.60.1.108 |
0.391 |
|
| 1987 |
Terman BI, Slivka SR, Hughes RJ, Insel PA. Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells. Molecular Pharmacology. 31: 12-20. PMID 3027523 |
0.307 |
|
| 1987 |
Maisel AS, Motulsky HJ, Insel PA. Life cycles of cardiac alpha 1- and beta-adrenergic receptors. Biochemical Pharmacology. 36: 1-6. PMID 3026400 DOI: 10.1016/0006-2952(87)90375-3 |
0.331 |
|
| 1987 |
Hughes RJ, Struthers RS, Fong AM, Insel PA. Regulation of the atrial natriuretic peptide receptor on a smooth muscle cell. The American Journal of Physiology. 253: C809-16. PMID 2827497 DOI: 10.1152/Ajpcell.1987.253.6.C809 |
0.377 |
|
| 1987 |
Maisel AS, Motulsky HJ, Ziegler MG, Insel PA. Ischemia- and agonist-induced changes in alpha- and beta-adrenergic receptor traffic in guinea pig hearts. The American Journal of Physiology. 253: H1159-66. PMID 2825544 DOI: 10.1152/Ajpheart.1987.253.5.H1159 |
0.377 |
|
| 1986 |
Shattil SJ, Motulsky HJ, Insel PA, Flaherty L, Brass LF. Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine. Blood. 68: 1224-31. PMID 3779100 DOI: 10.1182/Blood.V68.6.1224.1224 |
0.338 |
|
| 1986 |
Mahan LC, Insel PA. Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. II. Relationship between receptor number and response. Molecular Pharmacology. 29: 16-22. PMID 3003560 |
0.339 |
|
| 1986 |
Mahan LC, Insel PA. Expression of beta-adrenergic receptors in synchronous and asynchronous S49 lymphoma cells. I. Receptor metabolism after irreversible blockade of receptors and in cells traversing the cell division cycle. Molecular Pharmacology. 29: 7-15. PMID 2868411 |
0.309 |
|
| 1985 |
Wheeler AH, Ziegler MG, Insel PA, Motulsky HJ. Episodic catatonia, hypertension, and tachycardia: elevated plasma catecholamines. Neurology. 35: 1053-5. PMID 4010946 DOI: 10.1212/WNL.35.7.1053 |
0.306 |
|
| 1985 |
Snavely MD, Ziegler MG, Insel PA. Subtype-selective down-regulation of rat renal cortical alpha- and beta-adrenergic receptors by catecholamines. Endocrinology. 117: 2182-9. PMID 2995007 DOI: 10.1210/endo-117-5-2182 |
0.354 |
|
| 1985 |
Maisel AS, Motulsky HJ, Insel PA. Externalization of beta-adrenergic receptors promoted by myocardial ischemia. Science (New York, N.Y.). 230: 183-6. PMID 2994229 DOI: 10.1126/Science.2994229 |
0.42 |
|
| 1985 |
Insel PA, Motulsky HJ, Mahan LC. Regulation of cyclic AMP accumulation in lymphoid cells. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 179: 472-8. PMID 2991940 DOI: 10.3181/00379727-179-42125 |
0.451 |
|
| 1985 |
Mahan LC, Koachman AM, Insel PA. Genetic analysis of beta-adrenergic receptor internalization and down-regulation. Proceedings of the National Academy of Sciences of the United States of America. 82: 129-33. PMID 2982140 DOI: 10.1073/PNAS.82.1.129 |
0.436 |
|
| 1985 |
Mahan LC, Motulsky HJ, Insel PA. Do agonists promote rapid internalization of beta-adrenergic receptors? Proceedings of the National Academy of Sciences of the United States of America. 82: 6566-70. PMID 2864689 DOI: 10.1073/Pnas.82.19.6566 |
0.404 |
|
| 1984 |
Mahan LC, Insel PA. Use of superoxide dismutase and catalase to protect catecholamines from oxidation in tissue culture studies. Analytical Biochemistry. 136: 208-216. PMID 6711809 DOI: 10.1016/0003-2697(84)90327-0 |
0.303 |
|
| 1984 |
Motulsky HJ, Insel PA. ADP- and epinephrine-elicited release of [3H]guanylylimidodiphosphate from platelet membranes. Implications for receptor-Ni stoichiometry. Febs Letters. 164: 13-6. PMID 6653777 DOI: 10.1016/0014-5793(83)80008-8 |
0.376 |
|
| 1984 |
Insel PA. Identification and regulation of adrenergic receptors in target cells. The American Journal of Physiology. 247: E53-8. PMID 6331190 DOI: 10.1152/AJPENDO.1984.247.1.E53 |
0.412 |
|
| 1984 |
Darfler FJ, Mullen MD, Insel PA. Serum-stimulated cyclic-AMP production in S49 lymphoma cells grown in serum-free medium. Biochimica Et Biophysica Acta. 803: 203-9. PMID 6322858 DOI: 10.1016/0167-4889(84)90011-9 |
0.318 |
|
| 1984 |
Insel PA, Motulsky HJ. A hypothesis linking intracellular sodium, membrane receptors, and hypertension. Life Sciences. 34: 1009-13. PMID 6321865 DOI: 10.1016/0024-3205(84)90013-4 |
0.389 |
|
| 1984 |
Meier KE, Sternfeld DR, Insel PA. Alpha 1- and beta 2-adrenergic receptors co-expressed on cloned MDCK cells are distinct glycoproteins. Biochemical and Biophysical Research Communications. 118: 73-81. PMID 6320834 DOI: 10.1016/0006-291X(84)91069-6 |
0.369 |
|
| 1984 |
Motulsky HJ, Maisel AS, Snavely MD, Insel PA. Quinidine is a competitive antagonist at alpha 1- and alpha 2-adrenergic receptors. Circulation Research. 55: 376-381. PMID 6147208 DOI: 10.1161/01.Res.55.3.376 |
0.35 |
|
| 1983 |
Stengel D, Guenet L, Desmier M, Insel P, Hanoune J. Forskolin requires more than the catalytic unit to activate adenylate cyclase. Molecular and Cellular Endocrinology. 28: 681-90. PMID 6891346 DOI: 10.1016/0303-7207(82)90155-1 |
0.318 |
|
| 1983 |
Snavely MD, Mahan LC, O'Connor DT, Insel PA. Selective down-regulation of adrenergic receptor subtypes in tissues from rats with pheochromocytoma. Endocrinology. 113: 354-61. PMID 6861707 DOI: 10.1210/ENDO-113-1-354 |
0.388 |
|
| 1983 |
Hughes RJ, Insel PA. Human platelets are defective in processing of cholera toxin. The Biochemical Journal. 212: 669-78. PMID 6309151 DOI: 10.1042/BJ2120669 |
0.331 |
|
| 1983 |
Motulsky HJ, Snavely MD, Hughes RJ, Insel PA. Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors. Circulation Research. 52: 226-31. PMID 6297831 DOI: 10.1161/01.RES.52.2.226 |
0.329 |
|
| 1983 |
Motulsky HJ, O'Connor DT, Insel PA. Platelet alpha 2-adrenergic receptors in treated and untreated essential hypertension. Clinical Science (London, England : 1979). 64: 265-72. PMID 6295690 DOI: 10.1042/CS0640265 |
0.359 |
|
| 1982 |
Darfler FJ, Insel PA. Serum-free culture of resting, PHA-stimulated, and transformed lymphoid cells, including hybridomas. Experimental Cell Research. 138: 287-295. PMID 7042376 DOI: 10.1016/0014-4827(82)90177-X |
0.308 |
|
| 1982 |
Snavely MD, Motulsky HJ, Moustafa E, Mahan LC, Insel PA. beta-Adrenergic receptor subtypes in the rat renal cortex. Selective regulation of beta 1-adrenergic receptors by pheochromocytoma. Circulation Research. 51: 504-13. PMID 6290097 DOI: 10.1161/01.RES.51.4.504 |
0.338 |
|
| 1982 |
Motulsky HJ, Hughes RJ, Brickman AS, Farfel Z, Bourne HR, Insel PA. Platelets of pseudohypoparathyroid patients: evidence that distinct receptor-cyclase coupling proteins mediate stimulation and inhibition of adenylate cyclase. Proceedings of the National Academy of Sciences of the United States of America. 79: 4193-7. PMID 6287473 DOI: 10.1073/Pnas.79.13.4193 |
0.33 |
|
| 1982 |
Snavely MD, Motulsky HJ, O'Connor DT, Ziegler MG, Insel PA. Adrenergic receptors in human and experimental pheochromocytoma. Clinical and Experimental Hypertension. Part a, Theory and Practice. 4: 829-48. PMID 6286177 DOI: 10.3109/10641968209061616 |
0.385 |
|
| 1982 |
Dibner MD, Insel PA. Growth of C6 glioma cells in serum-containing medium decreases beta-adrenergic receptor number. Journal of Cellular Physiology. 109: 309-15. PMID 6271796 DOI: 10.1002/JCP.1041090214 |
0.376 |
|
| 1982 |
Motulsky HJ, Insel PA. Adrenergic receptors in man: direct identification, physiologic regulation, and clinical alterations. The New England Journal of Medicine. 307: 18-29. PMID 6123082 DOI: 10.1056/NEJM198207013070104 |
0.406 |
|
| 1981 |
Insel PA, Darfler FJ, Kennedy MS. Cholera toxin can recouple hormone receptors that are uncoupled from adenylate cyclase. Febs Letters. 128: 59-62. PMID 6268451 DOI: 10.1016/0014-5793(81)81079-4 |
0.373 |
|
| 1981 |
Motulsky HJ, Shattil SJ, Insel PA. Characterization of alpha 2-adrenergic receptors on human platelets using [3H]yohimbine. Biochemical and Biophysical Research Communications. 97: 1562-70. PMID 6260094 DOI: 10.1016/S0006-291X(80)80044-1 |
0.324 |
|
| 1981 |
Dibner MD, Wolfe RA, Insel PA. Replacement of serum with a defined medium increases beta-adrenergic receptor number in cultured glioma cells. Experimental Cell Research. 131: 424-7. PMID 6258950 DOI: 10.1016/0014-4827(81)90249-4 |
0.387 |
|
| 1980 |
Roberts JM, Goldfien A, Insel PA. Dihydroergocryptine binding and α-adrenoreceptors in smooth muscle Nature. 283: 108-109. PMID 6243174 DOI: 10.1038/283108B0 |
0.707 |
|
| 1980 |
Galant SP, Duriseti L, Underwood S, Allred S, Insel PA. Beta adrenergic receptors of polymorphonuclear particulates in bronchial asthma. The Journal of Clinical Investigation. 65: 577-85. PMID 6101600 DOI: 10.1172/JCI109702 |
0.334 |
|
| 1979 |
Kaiser N, Bourne HR, Insel PA, Coffino P. Regulation of phosphodiesterase and ornithine decarboxylase by cAMP is cell cycle independent. Journal of Cellular Physiology. 101: 369-74. PMID 231036 DOI: 10.1002/Jcp.1041010304 |
0.358 |
|
| 1979 |
Roberts JM, Goldfien RD, Tsuchiya AM, Goldfien A, Insel PA. Estrogen treatment decreases alpha-adrenergic binding sites on rabbit platelets. Endocrinology. 104: 722-8. PMID 220019 DOI: 10.1210/ENDO-104-3-722 |
0.761 |
|
| 1979 |
Insel PA, Nirenberg P, Turnbull J, Shattil SJ. Relationships between membrane cholesterol, alpha-adrenergic receptors, and platelet function. Biochemistry. 17: 5269-74. PMID 215196 DOI: 10.1021/BI00617A029 |
0.326 |
|
| 1978 |
Insel PA, Kennedy MS. Colchicine potentiates β-adrenoreceptor-stimulated cyclic AMP in lymphoma cells by an action distal to the receptor Nature. 273: 471-473. PMID 207995 DOI: 10.1038/273471a0 |
0.401 |
|
| 1978 |
Insel PA, Fenno J. Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities. Proceedings of the National Academy of Sciences of the United States of America. 75: 862-5. PMID 204937 DOI: 10.1073/PNAS.75.2.862 |
0.366 |
|
| 1978 |
Roberts JM, Insel PA, Goldfien RD, Goldfien A. Identification of beta-adrenergic binding sites in rabbit myometrium. Endocrinology. 101: 1839-43. PMID 201450 DOI: 10.1210/ENDO-101-6-1839 |
0.752 |
|
| 1978 |
Galant SP, Duriseti L, Underwood S, Insel PA. Decreased beta-adrenergic receptors on polymorphonuclear leukocytes after adrenergic therapy. The New England Journal of Medicine. 299: 933-6. PMID 29223 DOI: 10.1056/NEJM197810262991707 |
0.43 |
|
| 1977 |
Roberts JM, Insel PA, Goldfien RD, Goldfien A. α adrenoreceptors but not β adrenoreceptors increase in rabbit uterus with oestrogen Nature. 270: 624-625. PMID 201865 DOI: 10.1038/270624A0 |
0.742 |
|
| 1977 |
Hochman J, Bourne HR, Coffino P, Insel PA, Krasny L, Melmon KL. Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 74: 1167-71. PMID 191831 DOI: 10.1073/Pnas.74.3.1167 |
0.322 |
|
| 1976 |
Shear M, Insel PA, Melmon KL, Coffino P. Agonist specific refractoriness induced by isoproterenol. Studies with mutant cells Journal of Biological Chemistry. 251: 7572-7576. PMID 187593 |
0.339 |
|
| 1976 |
Coffino P, Bourne HR, Friedrich U, Hochman J, Insel PA, Lemaire I, Melmon KL, Tomkins GM. Molecular mechanisms of cyclic AMP action: a genetic approach. Recent Progress in Hormone Research. 32: 669-84. PMID 183250 DOI: 10.1016/B978-0-12-571132-6.50037-3 |
0.34 |
|
| 1976 |
Coffino P, Bourne HR, Hochman J, Insel P, Melmon KL, Tomkins GM. Hormone-Mediated Lymphoma Cell Death: Mechanisms Of Glucocorticoid And Cyclic Amp Action Journal of Investigative Dermatology. 67: 648-649. DOI: 10.1111/1523-1747.Ep12544455 |
0.308 |
|
| 1975 |
Hochman J, Insel PA, Bourne HR, Coffino P, Tomkins GM. A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 72: 5051-5. PMID 174091 DOI: 10.1073/Pnas.72.12.5051 |
0.352 |
|
| 1975 |
Insel PA, Bourne HR, Coffino P, Tomkins GM. Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (New York, N.Y.). 190: 896-8. PMID 171770 DOI: 10.1126/Science.171770 |
0.359 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1993 |
Michel MC, Brodde OE, Insel PA. Are cardiac G-proteins altered in rat models of hypertension? Journal of Hypertension. 11: 355-63. PMID 8390502 DOI: 10.1097/00004872-199304000-00005 |
0.3 |
|
| 1985 |
De Blasi A, Lipartiti M, Motulsky HJ, Insel PA, Fratelli M. Agonist-induced redistribution of beta-adrenergic receptors on intact human mononuclear leukocytes: redistributed receptors are nonfunctional. The Journal of Clinical Endocrinology and Metabolism. 61: 1081-8. PMID 2865270 DOI: 10.1210/jcem-61-6-1081 |
0.299 |
|
| 1986 |
Hughes RJ, Insel PA. Agonist-mediated regulation of alpha 1- and beta 2-adrenergic receptor metabolism in a muscle cell line, BC3H-1. Molecular Pharmacology. 29: 521-30. PMID 3012317 |
0.299 |
|
| 1982 |
Karliner JS, Motulsky HJ, Dunlap J, Brown JH, Insel PA. Verapamil competitively inhibits alpha 1-adrenergic and muscarinic but not beta-adrenergic receptors in rat myocardium. Journal of Cardiovascular Pharmacology. 4: 515-20. PMID 6177951 DOI: 10.1097/00005344-198205000-00025 |
0.298 |
|
| 2001 |
Büscher R, Belger H, Eilmes KJ, Tellkamp R, Radke J, Dhein S, Hoyer PF, Michel MC, Insel PA, Brodde OE. In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans. Pharmacogenetics. 11: 199-205. PMID 11337935 DOI: 10.1097/00008571-200104000-00003 |
0.297 |
|
| 1985 |
Maisel AS, Motulsky HJ, Insel PA. Hypotension after quinidine plus verapamil. Possible additive competition at alpha-adrenergic receptors. The New England Journal of Medicine. 312: 167-70. PMID 2981405 DOI: 10.1056/NEJM198501173120308 |
0.296 |
|
| 1993 |
Leiber D, Jasper JR, Alousi AA, Martin J, Bernstein D, Insel PA. Alteration in Gs-mediated signal transduction in S49 lymphoma cells treated with inhibitors of microtubules. The Journal of Biological Chemistry. 268: 3833-7. PMID 8095044 |
0.296 |
|
| 2020 |
Gorr MW, Sriram K, Chinn AM, Muthusamy A, Insel PA. Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxia. Physiological Reports. 8: e14344. PMID 31960631 DOI: 10.14814/phy2.14344 |
0.295 |
|
| 1988 |
Jasper JR, Motulsky HJ, Insel PA. Characterization of a bromoacetylated derivative of pindolol as a high affinity, irreversible beta adrenergic antagonist in cultured cells. The Journal of Pharmacology and Experimental Therapeutics. 244: 820-4. PMID 2908047 |
0.294 |
|
| 2014 |
Foufelle F, Lotersztajn S, Insel PA, Chevet E. AJP-cell begins a theme series on cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. American Journal of Physiology. Cell Physiology. 307: C581. PMID 24990648 DOI: 10.1152/ajpcell.00221.2014 |
0.294 |
|
| 1992 |
Michel MC, Jäger S, Casto R, Rettig R, Graf C, Printz M, Insel PA, Philipp T, Brodde OE. On the role of renal alpha-adrenergic receptors in spontaneously hypertensive rats. Hypertension. 19: 365-70. PMID 1313395 DOI: 10.1161/01.Hyp.19.4.365 |
0.293 |
|
| 1996 |
Mochizuki N, Cho G, Wen B, Insel PA. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. Gene. 181: 39-43. PMID 8973305 DOI: 10.1016/S0378-1119(96)00456-8 |
0.292 |
|
| 2004 |
Siecke NW, Insel PA. Clarifying the effects of adrenergic receptor polymorphisms by measuring synaptic parameters. Journal of the American College of Cardiology. 44: 2016-8. PMID 15542285 DOI: 10.1016/j.jacc.2004.09.001 |
0.292 |
|
| 1984 |
Moustafa E, Snavely MD, Insel PA. Selective inhibition by organic mercurials of binding to the beta 1 population of rat renal cortical beta-adrenergic receptors. Biochemical Pharmacology. 33: 1148-51. PMID 6324814 DOI: 10.1016/0006-2952(84)90529-X |
0.292 |
|
| 1978 |
Coffino P, Bourne HR, Insel PA, Melmon KL, Johnson G, Vigne J. Studies of cyclic AMP action using mutant tissue culture cells. In Vitro. 14: 140-5. PMID 23989 DOI: 10.1007/Bf02618180 |
0.292 |
|
| 2003 |
Bruck H, Leineweber K, Büscher R, Ulrich A, Radke J, Insel PA, Brodde OE. The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo. Pharmacogenetics. 13: 59-66. PMID 12563174 DOI: 10.1097/00008571-200302000-00001 |
0.29 |
|
| 1997 |
Hammond HK, Ping P, Insel PA. Carondiac G-Protein Receptor Kinase Activity: Effect of a β-Adrenergic Receptor Antagonist Advances in Pharmacology. 42: 507-510. DOI: 10.1016/S1054-3589(08)60800-5 |
0.29 |
|
| 1999 |
Post SR, Hammond HK, Insel PA. Beta-adrenergic receptors and receptor signaling in heart failure. Annual Review of Pharmacology and Toxicology. 39: 343-60. PMID 10331088 DOI: 10.1146/annurev.pharmtox.39.1.343 |
0.289 |
|
| 1987 |
Slivka SR, Insel PA. Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2. The Journal of Biological Chemistry. 262: 4200-7. PMID 3031065 |
0.289 |
|
| 1998 |
Insel PA. α2-Adrenergic Receptors: Structure, Function and Therapeutic Implications Trends in Pharmacological Sciences. 19: 116. DOI: 10.1016/S0165-6147(98)01177-8 |
0.288 |
|
| 2009 |
Fung MM, Rana BK, Tang CM, Shiina T, Nievergelt CM, Rao F, Salem RM, Waalen J, Ziegler MG, Insel PA, O'Connor DT. Dopamine D1 receptor (DRD1) genetic polymorphism: pleiotropic effects on heritable renal traits. Kidney International. 76: 1070-80. PMID 19675531 DOI: 10.1038/ki.2009.306 |
0.288 |
|
| 1981 |
Insel PA, Snavely MD. Catecholamines and the kidney: receptors and renal function. Annual Review of Physiology. 43: 625-36. PMID 7011202 DOI: 10.1146/ANNUREV.PH.43.030181.003205 |
0.288 |
|
| 1990 |
Maisel AS, Ransnäs LA, Insel PA. Beta-adrenergic receptors and the Gs protein in myocardial ischemia and injury. Basic Research in Cardiology. 85: 47-56. PMID 1965404 |
0.287 |
|
| 2008 |
Rieg T, Pothula K, Schroth J, Satriano J, Osswald H, Schnermann J, Insel PA, Bundey RA, Vallon V. Vasopressin regulation of inner medullary collecting ducts and compensatory changes in mice lacking adenosine A1 receptors American Journal of Physiology - Renal Physiology. 294: F638-F644. PMID 18199602 DOI: 10.1152/Ajprenal.00344.2007 |
0.287 |
|
| 2000 |
Ostrom RS, Post SR, Insel PA. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). The Journal of Pharmacology and Experimental Therapeutics. 294: 407-12. PMID 10900212 |
0.287 |
|
| 2005 |
Etzel JP, Rana BK, Wen G, Parmer RJ, Schork NJ, O'Connor DT, Insel PA. Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response. Hypertension. 45: 1207-13. PMID 15920038 DOI: 10.1161/01.Hyp.0000166721.42734.49 |
0.286 |
|
| 1992 |
INSEL P. Gs protein regulation in the heart Journal of Molecular and Cellular Cardiology. 24: S70. DOI: 10.1016/0022-2828(92)91028-4 |
0.285 |
|
| 2013 |
Torday JS, Insel PA. AJP-Cell Physiology begins a Theme series on Evolution and Cell Physiology. American Journal of Physiology. Cell Physiology. 305: C681. PMID 23824845 DOI: 10.1152/ajpcell.00200.2013 |
0.285 |
|
| 1993 |
Jackson CA, Insel PA. Renal alpha-adrenergic receptors and genetic hypertension. Pediatric Nephrology (Berlin, Germany). 7: 853-8. PMID 8130120 DOI: 10.1007/BF01213373 |
0.285 |
|
| 1996 |
Lortie MJ, Novotny WF, Peterson OW, Vallon V, Malvey K, Mendonca M, Satriano J, Insel P, Thomson SC, Blantz RC. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. Journal of Clinical Investigation. 97: 413-420. PMID 8567962 DOI: 10.1172/Jci118430 |
0.284 |
|
| 1988 |
McKernan RM, Strickland WR, Insel PA. Selective blockade and recovery of cell surface alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. Studies with the irreversible antagonist benextramine. Molecular Pharmacology. 33: 51-7. PMID 2826999 |
0.282 |
|
| 1994 |
Saffitz JE, Nash JA, Green KG, Luke RA, Ransnas LA, Insel PA. Immunoelectron microscopic identification of cytoplasmic and nuclear Gs alpha in S49 lymphoma cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 252-8. PMID 8119495 DOI: 10.1096/Fasebj.8.2.8119495 |
0.282 |
|
| 2011 |
Zhang L, Murray F, Rassenti LZ, Pu M, Kelly C, Kanter JR, Greaves A, Messer K, Kipps TJ, Insel PA. Cyclic nucleotide phosphodiesterase 7B mRNA: an unfavorable characteristic in chronic lymphocytic leukemia. International Journal of Cancer. Journal International Du Cancer. 129: 1162-9. PMID 21120911 DOI: 10.1002/ijc.25785 |
0.281 |
|
| 1983 |
Darfler FJ, Insel PA. Clonal growth of lymphoid cells in serum-free media requires elimination of H2O2 toxicity. Journal of Cellular Physiology. 115: 31-6. PMID 6833406 DOI: 10.1002/JCP.1041150106 |
0.28 |
|
| 1986 |
Terman BI, Insel PA. Photoaffinity labeling of alpha 1-adrenergic receptors of rat heart. The Journal of Biological Chemistry. 261: 5603-9. PMID 3007515 |
0.279 |
|
| 1985 |
Meier KE, Sperling DM, Insel PA. Agonist-mediated regulation of alpha 1- and beta 2-adrenergic receptors in cloned MDCK cells. The American Journal of Physiology. 249: C69-77. PMID 2861747 DOI: 10.1152/AJPCELL.1985.249.1.C69 |
0.279 |
|
| 1992 |
Roth DA, Urasawa K, Leiber D, Insel PA, Hammond HK. A substantial proportion of cardiac Gs is not associated with the plasma membrane. Febs Letters. 296: 46-50. PMID 1730290 DOI: 10.1016/0014-5793(92)80400-B |
0.279 |
|
| 2013 |
Insel PA. The past, present, and future of AJP-cell American Journal of Physiology - Cell Physiology. 304: C1. DOI: 10.1152/ajpcell.00356.2012 |
0.278 |
|
| 1978 |
Kaywin P, McDonough M, Insel PA, Shattil SJ. Platelet function in essential thrombocythemia. Decreased epinephrine responsiveness associated with a deficiency of platelet alpha-adrenergic receptors. The New England Journal of Medicine. 299: 505-9. PMID 210377 DOI: 10.1056/NEJM197809072991002 |
0.278 |
|
| 1979 |
Johnson GL, Bourne HR, Gleason MK, Coffino P, Insel PA, Melmon KL. Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase. Molecular Pharmacology. 15: 16-27. PMID 34089 |
0.277 |
|
| 2010 |
Insel PA. Historical perspectives in cell physiology: Looking back to help the discipline move forward American Journal of Physiology - Cell Physiology. 298: C1279. PMID 20237145 DOI: 10.1152/ajpcell.00082.2010 |
0.277 |
|
| 1982 |
Motulsky HJ, Insel PA. [3H]Dihydroergocryptine binding to alpha-adrenergic receptors of human platelets. A reassessment using the selective radioligands [3H]prazosin, [3H]yohimbine, and [3H]rauwolscine. Biochemical Pharmacology. 31: 2591-7. PMID 6291538 DOI: 10.1016/0006-2952(82)90705-5 |
0.276 |
|
| 2007 |
Buscher R, Hoerning A, Rana BK, Rao F, O'Connor DT, Insel PA. Polymorphisms of {alpha}1a and {alpha}1b-adrenergic receptors help identify patients with arterial hypertension The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A422-B |
0.276 |
|
| 2018 |
Sriram K, Insel PA. GPCRs as targets for approved drugs: How many targets and how many drugs? Molecular Pharmacology. PMID 29298813 DOI: 10.1124/mol.117.111062 |
0.275 |
|
| 2019 |
Lee J, Zhang J, Chung Y, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo J, Tao A, Yasuda K, Rifkin IR, Broide DH, et al. Author response: Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses Elife. DOI: 10.7554/Elife.49416.Sa2 |
0.275 |
|
| 2003 |
Insel PA. Location, location, location. Trends in Endocrinology and Metabolism: Tem. 14: 100-2. PMID 12670730 DOI: 10.1016/S1043-2760(03)00029-8 |
0.275 |
|
| 2014 |
McCarty OJ, King MR, Insel PA. A theme series on physical biology in cancer in AJP-Cell. American Journal of Physiology. Cell Physiology. 306: C77. PMID 24067917 DOI: 10.1152/Ajpcell.00295.2013 |
0.275 |
|
| 1990 |
Maisel AS, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky HJ, Insel PA, Michel MC. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. The Journal of Clinical Investigation. 85: 462-7. PMID 2153706 DOI: 10.1172/JCI114460 |
0.274 |
|
| 1982 |
Insel PA, Honeysett JM. Glucocorticoid-mediated inhibition of ornithine decarboxylyase activity in S49 lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 5669-72. PMID 6272311 DOI: 10.1073/PNAS.78.9.5669 |
0.274 |
|
| 2006 |
Murray F, Insel PA, Yuan JX. Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema. Respiratory Physiology & Neurobiology. 151: 192-208. PMID 16364695 DOI: 10.1016/j.resp.2005.10.003 |
0.273 |
|
| 2004 |
Le Corre P, Parmer RJ, Kailasam MT, Kennedy BP, Skaar TP, Ho H, Leverge R, Smith DW, Ziegler MG, Insel PA, Schork NJ, Flockhart DA, O'connor DT. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clinical Pharmacology and Therapeutics. 76: 139-53. PMID 15289791 DOI: 10.1016/j.clpt.2004.04.010 |
0.273 |
|
| 2008 |
Insel PA. AJP-Cell Physiology: The whole is greater than the sum of its parts American Journal of Physiology - Cell Physiology. 295: C1. DOI: 10.1152/ajpcell.zh0-5630.2008 |
0.271 |
|
| 1989 |
Ransnäs LA, Insel PA. Quantitation of a guanine nucleotide binding regulatory protein by an enzyme-linked immunosorbent competition assay. Analytical Biochemistry. 176: 185-90. PMID 2496621 DOI: 10.1016/0003-2697(89)90291-1 |
0.271 |
|
| 1991 |
Weiss BA, Insel PA. Intracellular Ca2+ and protein kinase C interact to regulate alpha 1-adrenergic- and bradykinin receptor-stimulated phospholipase A2 activation in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 266: 2126-33. PMID 1846614 |
0.27 |
|
| 2010 |
Lotersztajn S, Insel PA. American Journal of Physiology-Cell Physiology initiates a series of articles around a theme: Autophagy is the first theme American Journal of Physiology - Cell Physiology. 298: C775. PMID 20071687 DOI: 10.1152/ajpcell.00011.2010 |
0.269 |
|
| 1994 |
Michel MC, Insel PA. Comparison of cloned and pharmacologically defined rat tissue alpha 1-adrenoceptor subtypes. Naunyn-Schmiedeberg's Archives of Pharmacology. 350: 136-42. PMID 7990970 DOI: 10.1007/Bf00241087 |
0.269 |
|
| 2020 |
Sriram K, Moyung K, Insel PA. New insights from The Cancer Genome Atlas: Implications for GPCR expression in cell compartments in solid tumors The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07453 |
0.267 |
|
| 1986 |
Motulsky HJ, Cunningham EM, DeBlasi A, Insel PA. Desensitization and redistribution of beta-adrenergic receptors on human mononuclear leukocytes. The American Journal of Physiology. 250: E583-90. PMID 3010734 |
0.267 |
|
| 1990 |
Jasper JR, Michel MC, Insel PA. Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists. Molecular Pharmacology. 37: 44-9. PMID 1967818 |
0.267 |
|
| 2018 |
Chang Y, Sriram K, Wang Z, Igawa S, Insel P, Di Nardo A. 853 Dermal fibroblasts control mast cell reactivity to commensal bacteria Journal of Investigative Dermatology. 138: S145. DOI: 10.1016/J.JID.2018.03.864 |
0.267 |
|
| 1992 |
Jackson CA, Michel MC, Insel PA. Expression of renal alpha 1-adrenergic receptor subtypes in established hypertension. Journal of Cardiovascular Pharmacology. 19: 857-62. PMID 1376804 DOI: 10.1097/00005344-199206000-00003 |
0.266 |
|
| 1988 |
Ransnäs LA, Insel PA. Quantitation of the guanine nucleotide binding regulatory protein Gs in S49 cell membranes using antipeptide antibodies to alpha s. The Journal of Biological Chemistry. 263: 9482-5. PMID 2837489 |
0.265 |
|
| 2002 |
Büscher R, Eilmes KJ, Grasemann H, Torres B, Knauer N, Sroka K, Insel PA, Ratjen F. beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease. Pharmacogenetics. 12: 347-53. PMID 12142724 DOI: 10.1097/00008571-200207000-00002 |
0.263 |
|
| 2011 |
Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, ... ... Insel PA, et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (Nature (2011) 471 (499-501)) Nature. 474: 114. DOI: 10.1038/Nature10088 |
0.262 |
|
| 2007 |
Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, Schork NJ, O'Connor DT. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension. 49: 96-106. PMID 17159089 DOI: 10.1161/01.Hyp.0000252029.35106.67 |
0.261 |
|
| 2011 |
Murray F, Maclean MR, Insel PA. Role of phosphodiesterases in adult-onset pulmonary arterial hypertension. Handbook of Experimental Pharmacology. 279-305. PMID 21695645 DOI: 10.1007/978-3-642-17969-3_12 |
0.261 |
|
| 2010 |
Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proceedings of the National Academy of Sciences of the United States of America. 107: 10638-43. PMID 20479237 DOI: 10.1073/pnas.1002348107 |
0.26 |
|
| 2011 |
Peiró AM, Tang CM, Murray F, Zhang L, Brown LM, Chou D, Rassenti L, Kipps TJ, Kipps TA, Insel PA. Genetic variation in phosphodiesterase (PDE) 7B in chronic lymphocytic leukemia: overview of genetic variants of cyclic nucleotide PDEs in human disease. Journal of Human Genetics. 56: 676-81. PMID 21796143 DOI: 10.1038/jhg.2011.80 |
0.26 |
|
| 2005 |
Tang CM, Hoerning A, Büscher R, O'Connor DT, Ratjen F, Grasemann H, Insel PA. Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis. Pharmacogenetics and Genomics. 15: 321-7. PMID 15864133 DOI: 10.1097/01213011-200505000-00007 |
0.26 |
|
| 2012 |
Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Martin B, Maudsley S, Shen RF. Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD). Journal of Proteomics. 75: 2480-7. PMID 22397766 DOI: 10.1016/J.Jprot.2012.02.027 |
0.259 |
|
| 1987 |
McKernan RM, Howard MJ, Motulsky HJ, Insel PA. Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells. Molecular Pharmacology. 32: 258-65. PMID 3039340 |
0.259 |
|
| 1994 |
Büscher R, Insel PA, Michel MC. Is SDZ NVI-085 an alpha 1-adrenoceptor subtype-selective agonist? Life Sciences. 54: 999-1007. PMID 7908116 DOI: 10.1016/0024-3205(94)00502-8 |
0.259 |
|
| 2006 |
Hoekstra HE, Hirschmann RJ, Bundey RA, Insel PA, Crossland JP. A single amino acid mutation contributes to adaptive beach mouse color pattern. Science (New York, N.Y.). 313: 101-4. PMID 16825572 DOI: 10.1126/Science.1126121 |
0.258 |
|
| 1998 |
Yang M, Büscher R, Taguchi K, Grübbel B, Insel PA, Michel MC. Protein kinase C does not mediate phenylephrine-induced down-regulation of Madin-Darby canine kidney cell alpha-1B adrenoceptors. The Journal of Pharmacology and Experimental Therapeutics. 286: 36-43. PMID 9655839 |
0.257 |
|
| 1988 |
Slivka SR, Insel PA. Phorbol ester and neomycin dissociate bradykinin receptor-mediated arachidonic acid release and polyphosphoinositide hydrolysis in Madin-Darby canine kidney cells. Evidence that bradykinin mediates noninterdependent activation of phospholipases A2 and C. The Journal of Biological Chemistry. 263: 14640-7. PMID 2902085 |
0.256 |
|
| 2020 |
Sriram K, Insel PA. Inflammation and thrombosis in COVID-19 pathophysiology: Proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets. Physiological Reviews. PMID 33124941 DOI: 10.1152/physrev.00035.2020 |
0.253 |
|
| 1989 |
Weiss BA, Slivka SR, Insel PA. Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells. Molecular Pharmacology. 36: 317-26. PMID 2549387 |
0.252 |
|
| 2011 |
Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov V, Yoon S, Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach-Walters V, Welsh DK, ... ... Insel PA, et al. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature. 471: 499-503. PMID 21346763 DOI: 10.1038/Nature09884 |
0.25 |
|
| 2014 |
Fuller CM, Insel PA. I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?". American Journal of Physiology. Cell Physiology. 306: C1-2. PMID 24225885 DOI: 10.1152/ajpcell.00342.2013 |
0.249 |
|
| 2020 |
Chinn AM, Insel PA. Cyclic AMP in dendritic cells: a novel potential target for disease-modifying agents in asthma and other allergic disorders. British Journal of Pharmacology. PMID 32372523 DOI: 10.1111/bph.15095 |
0.248 |
|
| 2000 |
Post SR, Ostrom RS, Insel PA. Biochemical methods for detection and measurement of cyclic AMP and adenylyl cyclase activity. Methods in Molecular Biology (Clifton, N.J.). 126: 363-74. PMID 10685423 DOI: 10.1385/1-59259-684-3:363 |
0.248 |
|
| 2016 |
Insel PA, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology". Annual Review of Pharmacology and Toxicology. PMID 27732830 DOI: 10.1146/annurev-pharmtox-091616-023708 |
0.248 |
|
| 1988 |
Ransnäs LA, Insel PA. Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes. The Journal of Biological Chemistry. 263: 17239-42. PMID 3141418 |
0.246 |
|
| 2011 |
Kleyman TR, Insel PA, Frank M. Editor's Note: AJP-Cell and AJP-Renal article series to honor the work of Dale Benos. American Journal of Physiology. Cell Physiology. 301: C749. PMID 21795524 DOI: 10.1152/ajpcell.00264.2011 |
0.246 |
|
| 1988 |
Insel PA, Ransnäs LA. G proteins and cardiovascular disease. Circulation. 78: 1511-3. PMID 3142698 DOI: 10.1161/01.Cir.78.6.1511 |
0.245 |
|
| 1991 |
Hughes RJ, Howard MJ, Allen JM, Insel PA. Decreased beta 2-adrenergic receptor mRNA expression in receptor-deficient S49 lymphoma cells. Molecular Pharmacology. 40: 974-9. PMID 1661841 |
0.244 |
|
| 2017 |
Insel PA, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development". Annual Review of Pharmacology and Toxicology. PMID 29058990 DOI: 10.1146/annurev-pharmtox-092617-121952 |
0.243 |
|
| 2001 |
Rana BK, Pan L, Insel PA. Use of an in silico approach to define the gene structure of eukaryotic adenylyl cyclases. Biochemical and Biophysical Research Communications. 285: 152-7. PMID 11437386 DOI: 10.1006/bbrc.2001.5096 |
0.239 |
|
| 2023 |
Greenwald E, Posner C, Bharath A, Lyons A, Salmerón C, Sriram K, Wiley SZ, Insel PA, Zhang J. GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System. Acs Sensors. PMID 36602887 DOI: 10.1021/acssensors.2c01341 |
0.238 |
|
| 2010 |
Levi M, Insel PA. AJP-Cell Physiology initiates publication of the Hans H. Ussing Lecture. American Journal of Physiology. Cell Physiology. 299: C1221. PMID 20881237 DOI: 10.1152/ajpcell.00391.2010 |
0.236 |
|
| 1984 |
Münzel PA, Healy DP, Insel PA. Autoradiographic localization of beta-adrenergic receptors in rat kidney slices using [125I]iodocyanopindolol. The American Journal of Physiology. 246: F240-5. PMID 6320680 DOI: 10.1152/AJPRENAL.1984.246.2.F240 |
0.236 |
|
| 2020 |
Gorr MW, Sriram K, Muthusamy A, Insel PA. Transcriptomic Analysis of Pulmonary Artery Smooth Muscle Cells Identifies New Potential Therapeutic Targets for Idiopathic Pulmonary Arterial Hypertension. British Journal of Pharmacology. PMID 32337710 DOI: 10.1111/bph.15074 |
0.235 |
|
| 2020 |
Izzo AA, Teixeira M, Alexander SPH, Cirino G, Docherty JR, George CH, Insel PA, Ji Y, Kendall DA, Panattieri RA, Sobey CG, Stanford SC, Stefanska B, Stephens G, Ahluwalia A. A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research. British Journal of Pharmacology. PMID 32298474 DOI: 10.1111/Bph.15054 |
0.232 |
|
| 1991 |
Klijn K, Slivka SR, Bell K, Insel PA. Renal alpha 1-adrenergic receptor subtypes: MDCK-D1 cells, but not rat cortical membranes possess a single population of receptors. Molecular Pharmacology. 39: 407-13. PMID 1848662 |
0.232 |
|
| 2000 |
O'Connor DT, Insel PA, Ziegler MG, Hook VY, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. Heredity and the autonomic nervous system in human hypertension. Current Hypertension Reports. 2: 16-22. PMID 10982526 DOI: 10.1007/S11906-000-0053-8 |
0.232 |
|
| 1987 |
Howard MJ, Hughes RJ, Motulsky HJ, Mullen MD, Insel PA. Interactions of amiloride with alpha- and beta-adrenergic receptors: amiloride reveals an allosteric site on alpha 2-adrenergic receptors. Molecular Pharmacology. 32: 53-8. PMID 3037303 |
0.231 |
|
| 2021 |
Sriram K, Insel MB, Insel PA. Inhaled 2 Adrenergic Agonists and Other cAMP-Elevating Agents: Therapeutics for Alveolar Injury and Acute Respiratory Disease Syndrome? Pharmacological Reviews. 73: 488-526. PMID 34795026 DOI: 10.1124/pharmrev.121.000356 |
0.23 |
|
| 2003 |
Koopmans RP, Insel PA, Michel MC. Pharmacogenetics of hypertension treatment: a structured review. Pharmacogenetics. 13: 705-13. PMID 14646689 DOI: 10.1097/01.fpc.0000054142.14659.f3 |
0.23 |
|
| 1993 |
Godson C, Bell KS, Insel PA. Inhibition of expression of protein kinase C alpha by antisense cDNA inhibits phorbol ester-mediated arachidonate release. The Journal of Biological Chemistry. 268: 11946-50. PMID 7685027 |
0.23 |
|
| 1990 |
Godson C, Weiss BA, Insel PA. Differential activation of protein kinase C alpha is associated with arachidonate release in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 265: 8369-72. PMID 2341388 |
0.225 |
|
| 2013 |
Lotersztajn S, Insel PA. AJP-Cell begins a theme series on tissue fibrosis. American Journal of Physiology. Cell Physiology. 304: C215. PMID 23255579 DOI: 10.1152/ajpcell.00405.2012 |
0.22 |
|
| 2020 |
Lilley E, Stanford SC, Kendall DE, Alexander SPH, Cirino G, Docherty JR, George CH, Insel PA, Izzo AA, Ji Y, Panettieri RA, Sobey CG, Stefanska B, Stephens G, Teixeira M, et al. ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020. British Journal of Pharmacology. PMID 32662875 DOI: 10.1111/Bph.15178 |
0.218 |
|
| 1986 |
Insel PA. Cardiovascular alpha 2-adrenoceptors. Journal of Molecular and Cellular Cardiology. 18: 457-9. PMID 2873252 DOI: 10.1016/S0022-2828(86)80909-9 |
0.214 |
|
| 1991 |
Michel MC, Casto R, Printz M, Brodde O, Insel PA. 103. Are renal ??-adrenoceptor alterations a major cause of genetic hypertension in the spontaneously hypertensive rat? Journal of Hypertension. 9: S466. DOI: 10.1097/00004872-199112000-00294 |
0.214 |
|
| 2020 |
Sriram K, Loomba R, Insel PA. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges. Proceedings of the National Academy of Sciences of the United States of America. 117: 29274-29282. PMID 33203679 DOI: 10.1073/pnas.2009875117 |
0.212 |
|
| 2011 |
Wu WW, Wang G, Insel PA, Hsiao CT, Zou S, Maudsley S, Martin B, Shen RF. Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). Journal of the American Society For Mass Spectrometry. 22: 1753-62. PMID 21952889 DOI: 10.1007/S13361-011-0197-6 |
0.212 |
|
| 2019 |
Insel PA, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "New Therapeutic Targets". Annual Review of Pharmacology and Toxicology. 59: 15-20. PMID 30625286 DOI: 10.1146/annurev-pharmtox-101018-112717 |
0.207 |
|
| 1988 |
Hughes RJ, Struthers RS, Fong AM, Insel PA. Receptor-induced degradation of atrial natriuretic peptide by a rabbit carotid artery smooth muscle cell. Molecular Endocrinology (Baltimore, Md.). 2: 117-24. PMID 2840569 DOI: 10.1210/mend-2-2-117 |
0.206 |
|
| 2008 |
Michel MC, Jasper JR, Insel P. Adrenoceptors: a convergence of thinking. Molecular Interventions. 2: 198-200. PMID 14993387 DOI: 10.1124/MI.2.4.198 |
0.205 |
|
| 2018 |
Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S, et al. Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. British Journal of Pharmacology. 175: 987-993. PMID 29520785 DOI: 10.1111/Bph.14153 |
0.203 |
|
| 2009 |
Braun OO, Insel PA. The Best "Model System" for Human (Coronary Arteries) Is Human Journal of the American College of Cardiology. 54: 1146-1148. PMID 19761934 DOI: 10.1016/j.jacc.2009.06.019 |
0.203 |
|
| 1976 |
Insel PA, Maguire ME, Gilman AC. Are beta adrenergic receptors and adenylate cyclase (AC) separately derived gene products? Federation Proceedings. 35: no. 1203. |
0.203 |
|
| 1999 |
Büscher R, Herrmann V, Insel PA. Human adrenoceptor polymorphisms: evolving recognition of clinical importance. Trends in Pharmacological Sciences. 20: 94-9. PMID 10203863 DOI: 10.1016/S0165-6147(99)01322-X |
0.202 |
|
| 2019 |
Sriram K, Wiley SZ, Moyung K, Gorr MW, Salmerón C, Marucut J, French RP, Lowy AM, Insel PA. Detection and Quantification of GPCR mRNA: An Assessment and Implications of Data from High-Content Methods. Acs Omega. 4: 17048-17059. PMID 31646252 DOI: 10.1021/acsomega.9b02811 |
0.202 |
|
| 1989 |
Michel MC, Insel PA. Are there multiple imidazoline binding sites? Trends in Pharmacological Sciences. 10: 342-4. PMID 2690423 DOI: 10.1016/0165-6147(89)90002-3 |
0.202 |
|
| 2020 |
Salmerón C, Sriram K, Baird A, Insel P. HRH1 in Human and Mouse Pancreatic Cancer The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06334 |
0.199 |
|
| 1982 |
Hughes RJ, Boyle MR, Brown RD, Taylor P, Insel PA. Characterization of coexisting alpha 1- and beta 2-adrenergic receptors on a cloned muscle cell line, BC3H-1. Molecular Pharmacology. 22: 258-66. PMID 6128668 |
0.198 |
|
| 1976 |
Insel PA, Maguire ME, Gilman AG, Bourne HR, Coffino P, Melmon KL. Beta adrenergic receptors and adenylate cyclase: products of separate genes? Molecular Pharmacology. 12: 1062-9. PMID 187924 |
0.198 |
|
| 2018 |
Alexander SPH, Roberts RE, Broughton BRS, Sobey CG, George CH, Stanford SC, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Mangum J, et al. Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. British Journal of Pharmacology. 175: 407-411. PMID 29350411 DOI: 10.1111/Bph.14112 |
0.196 |
|
| 2003 |
Insel PA, Kirstein SL. Naturally occurring variants in catecholamine receptor genes. Autonomic & Autacoid Pharmacology. 23: 228-30. PMID 15132132 |
0.195 |
|
| 2015 |
Insel PA, Amara SG, Blaschke TF, Meyer UA. Introduction to the Theme "Cancer Pharmacology". Annual Review of Pharmacology and Toxicology. PMID 26551200 DOI: 10.1146/annurev-pharmtox-102015-123106 |
0.195 |
|
| 2003 |
Bundey RA, Insel PA. Quantification of adenylyl cyclase messenger RNA by real-time polymerase chain reaction. Analytical Biochemistry. 319: 318-22. PMID 12871728 DOI: 10.1016/S0003-2697(03)00325-7 |
0.194 |
|
| 2020 |
Dolphin AC, Insel PA, Blaschke TF, Meyer UA. Introduction to the Theme "Ion Channels and Neuropharmacology: From the Past to the Future". Annual Review of Pharmacology and Toxicology. 60: 1-6. PMID 31914892 DOI: 10.1146/annurev-pharmtox-082719-110050 |
0.192 |
|
| 2017 |
George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S, Ahluwalia A. Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. British Journal of Pharmacology. 174: 2801-2804. PMID 28801996 DOI: 10.1111/Bph.13925 |
0.192 |
|
| 1985 |
Healy DP, Münzel PA, Insel PA. Localization of beta 1- and beta 2-adrenergic receptors in rat kidney by autoradiography. Circulation Research. 57: 278-84. PMID 2990758 |
0.192 |
|
| 1999 |
Büscher R, Herrmann V, Ring KM, Kailasam MT, O'Connor DT, Parmer RJ, Insel PA. Variability in phenylephrine response and essential hypertension: a search for human alpha(1B)-adrenergic receptor polymorphisms. The Journal of Pharmacology and Experimental Therapeutics. 291: 793-8. PMID 10525102 |
0.191 |
|
| 2004 |
Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. Blasts from the past. The Journal of Clinical Investigation. 114: 1017-33. PMID 15489944 DOI: 10.1172/Jci23321 |
0.191 |
|
| 1974 |
Sherwin RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist JE, Berman M, Andres R. A model of the kinetics of insulin in man. The Journal of Clinical Investigation. 53: 1481-92. PMID 4856884 DOI: 10.1172/Jci107697 |
0.19 |
|
| 1990 |
Michel MC, Regan JW, Gerhardt MA, Neubig RR, Insel PA, Motulsky HJ. Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors. Molecular Pharmacology. 37: 65-8. PMID 2153910 |
0.189 |
|
| 2015 |
Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SP, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LD, Wonnacott S, Weston AH, et al. Experimental design and analysis and their reporting: new guidance for publication in BJP. British Journal of Pharmacology. 172: 3461-71. PMID 26114403 DOI: 10.1111/Bph.12856 |
0.188 |
|
| 1986 |
Motulsky HJ, Shattil SJ, Ferry N, Rozansky D, Insel PA. Desensitization of epinephrine-initiated platelet aggregation does not alter binding to the alpha 2-adrenergic receptor or receptor coupling to adenylate cyclase. Molecular Pharmacology. 29: 1-6. PMID 2418346 |
0.188 |
|
| 2000 |
Glew RH, Insel PA. Academic health center administrators don't perish when they don't publish. Academic Medicine : Journal of the Association of American Medical Colleges. 75: 996-8. PMID 11031144 DOI: 10.1097/00001888-200010000-00013 |
0.187 |
|
| 1985 |
Insel PA, Snavely MD, Healy DP, Münzel PA, Potenza CL, Nord EP. Radioligand binding and functional assays demonstrate postsynaptic alpha 2-receptors on proximal tubules of rat and rabbit kidney. Journal of Cardiovascular Pharmacology. 7: S9-17. PMID 2417052 |
0.187 |
|
| 1975 |
Insel PA, Liljenquist JE, Tobin JD, Sherwin RS, Watkins P, Andres R, Berman M. Insulin control of glucose metabolism in man: a new kinetic analysis. The Journal of Clinical Investigation. 55: 1057-66. PMID 15959962 DOI: 10.1172/Jci108006 |
0.187 |
|
| 2013 |
Goldberg C, Insel PA. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training. Academic Medicine : Journal of the Association of American Medical Colleges. 88: 745-7. PMID 23708597 DOI: 10.1097/ACM.0b013e31828ffeeb |
0.186 |
|
| 2015 |
Insel PA, Amara SG, Blaschke TF. Introduction to the theme "Precision medicine and prediction in pharmacology". Annual Review of Pharmacology and Toxicology. 55: 11-4. PMID 25562643 DOI: 10.1146/annurev-pharmtox-101714-123102 |
0.185 |
|
| 2019 |
George CH, Alexander SPH, Cirino G, Docherty JR, Hoyer D, Insel PA, Izzo AA, Ji Y, Panettieri RA, Sobey CG, Stanford SC, Stefanska B, Stephens G, Teixeira M, Ahluwalia A. The BJP expects authors to share data. British Journal of Pharmacology. 176: 4595-4598. PMID 31950490 DOI: 10.1111/Bph.14907 |
0.184 |
|
| 1987 |
Nord EP, Howard MJ, Hafezi A, Moradeshagi P, Vaystub S, Insel PA. Alpha 2 adrenergic agonists stimulate Na+-H+ antiport activity in the rabbit renal proximal tubule. The Journal of Clinical Investigation. 80: 1755-62. PMID 2890661 DOI: 10.1172/JCI113268 |
0.184 |
|
| 1993 |
Insel PA, Hammond HK. Beta-adrenergic receptors in heart failure. The Journal of Clinical Investigation. 92: 2564. PMID 8254011 DOI: 10.1172/JCI116867 |
0.179 |
|
| 1997 |
Varki AP, Kagnoff MF, Insel PA. Passing the baton at high speed: time to hand over to a new editorial board. The Journal of Clinical Investigation. 99: 553-4. PMID 9045851 DOI: 10.1172/Jci119192 |
0.176 |
|
| 2022 |
Chinn AM, Salmerón C, Lee J, Sriram K, Raz E, Insel PA. PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells. Frontiers in Pharmacology. 13: 833832. PMID 35387344 DOI: 10.3389/fphar.2022.833832 |
0.175 |
|
| 2021 |
Sriram K, Salmerón C, Di Nardo A, Insel PA. Detection of GPCR mRNA Expression in Primary Cells Via qPCR, Microarrays, and RNA-Sequencing. Methods in Molecular Biology (Clifton, N.J.). 2268: 21-42. PMID 34085259 DOI: 10.1007/978-1-0716-1221-7_2 |
0.174 |
|
| 2005 |
Rana BK, Insel PA. Receptor databases and computational websites for ligand binding. Methods in Molecular Biology (Clifton, N.J.). 306: 1-15. PMID 15867461 DOI: 10.1385/1-59259-927-3:001 |
0.163 |
|
| 1990 |
Alousi A, Jasper J, Insel P, Motulsky H. The role of G proteins in the binding of 3H-forskolin by wild-type and variant S49 iymphoma cells and human mononuclear leukocytes European Journal of Pharmacology. 183: 2156-2157. DOI: 10.1016/0014-2999(90)93681-F |
0.161 |
|
| 1989 |
Michel MC, Brodde OE, Schnepel B, Behrendt J, Tschada R, Motulsky HJ, Insel PA. [3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Molecular Pharmacology. 35: 324-30. PMID 2564631 |
0.161 |
|
| 1987 |
Lotersztajn S, Pavoine C, Mallat A, Stengel D, Insel PA, Pecker F. Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase. The Journal of Biological Chemistry. 262: 3114-7. PMID 2950093 |
0.149 |
|
| 1996 |
Denker SP, McCaffery JM, Palade GE, Insel PA, Farquhar MG. Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. The Journal of Cell Biology. 133: 1027-40. PMID 8655576 DOI: 10.1083/jcb.133.5.1027 |
0.143 |
|
| 1977 |
Coffino P, Bourne HR, Insel PA. Use of mutant lymphoma cells to study mechanisms of cyclic AMP action In Vitro. 13: 142. |
0.141 |
|
| 1998 |
Dao TT, Kailasam MT, Parmer RJ, Le HV, Le Verge R, Kennedy BP, Ziegler G, Insel PA, Wright FA, O'Connor DT. Expression of altered alpha2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension. Journal of Hypertension. 16: 779-92. PMID 9663918 DOI: 10.1097/00004872-199816060-00009 |
0.134 |
|
| 2023 |
Di Nardo A, Chang YL, Alimohammadi S, Masuda-Kuroki K, Wang Z, Sriram K, Insel PA. Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts. Cell Reports. 42: 112453. PMID 37120813 DOI: 10.1016/j.celrep.2023.112453 |
0.131 |
|
| 2021 |
Costa M, Blaschke TF, Amara SG, Meyer UA, Insel PA. Introduction to the Theme "Old and New Toxicology: Interfaces with Pharmacology". Annual Review of Pharmacology and Toxicology. 61: 1-7. PMID 33411582 DOI: 10.1146/annurev-pharmtox-092220-033032 |
0.128 |
|
| 1994 |
Blue DR, Craig DA, Ransom JT, Camacho JA, Insel PA, Clarke DE. Characterization of the alpha-1 adrenoceptor subtype mediating [3H]-arachidonic acid release and calcium mobilization in Madin-Darby canine kidney cells. The Journal of Pharmacology and Experimental Therapeutics. 268: 1588-96. PMID 7908059 |
0.127 |
|
| 2008 |
Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 17, (6386-6391) DOI: 10.1073/pnas.0801490105) Proceedings of the National Academy of Sciences of the United States of America. 105: 8160. DOI: 10.1073/pnas.0804100105 |
0.091 |
|
| 1985 |
Insel PA, Snavely MD, Healy DP, M??nzel PA, Potenza CL, Nord EP. Radioligand Binding and Functional Assays Demonstrate Postsynaptic Alpha2Receptors on Proximal Tubules of Rat and Rabbit Kidney Journal of Cardiovascular Pharmacology. 7: S18. DOI: 10.1097/00005344-198500078-00002 |
0.084 |
|
| 2015 |
Brown JH, Catterall WA, Conn PJ, Cull-Candy SG, Dingledine R, Harden TK, Insel PA, Milligan G, Traynelis SF. The First 50 Years of Molecular Pharmacology. Molecular Pharmacology. 88: 139-40. PMID 25943115 DOI: 10.1124/mol.115.099564 |
0.066 |
|
| 2021 |
Insel PA, Blaschke TF, Amara SG, Meyer UA. Introduction to the Theme "New Insights, Strategies, and Therapeutics for Common Diseases". Annual Review of Pharmacology and Toxicology. PMID 34606327 DOI: 10.1146/annurev-pharmtox-091421-094627 |
0.063 |
|
| 2023 |
Meyer UA, Amara SG, Blaschke TF, Insel PA. Introduction to the Theme "Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment". Annual Review of Pharmacology and Toxicology. PMID 37816308 DOI: 10.1146/annurev-pharmtox-090123-010552 |
0.061 |
|
| 2022 |
Blaschke TF, Insel PA, Amara SG, Meyer UA. Introduction to the Theme "Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care". Annual Review of Pharmacology and Toxicology. PMID 36270297 DOI: 10.1146/annurev-pharmtox-091222-022612 |
0.055 |
|
| 2004 |
Insel PA. Molecular Pharmacology: Editor's Note Molecular Pharmacology. 65: 1. DOI: 10.1124/mol.65.1.1 |
0.052 |
|
| 2021 |
Ajmera V, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Sriram K, Insel PA, Collier S, Richards L, Loomba R. RAMIC: Design of a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of ramipril in patients with COVID-19. Contemporary Clinical Trials. 106330. PMID 33631357 DOI: 10.1016/j.cct.2021.106330 |
0.05 |
|
| 1996 |
Cohen JS, Insel PA. The Physicians' Desk Reference. Problems and possible improvements. Archives of Internal Medicine. 156: 1375-80. PMID 8678706 |
0.039 |
|
| 2020 |
Sriram K, Loomba R, Insel PA. RAAS Inhibitors and Risk of Covid-19. The New England Journal of Medicine. 383: 1991-1992. PMID 33108103 DOI: 10.1056/NEJMc2030446#sa2 |
0.035 |
|
| 2023 |
Huang DQ, Ajmera V, Tomaszewski C, LaFree A, Bettencourt R, Thompson WK, Smith DM, Malhotra A, Mehta RL, Tolia V, Yin J, Insel PA, Leachman S, Jung J, Collier S, et al. Ramipril for the Treatment of COVID-19: RAMIC, a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Advances in Therapy. PMID 37615850 DOI: 10.1007/s12325-023-02618-7 |
0.029 |
|
| 1997 |
Hooper PL, Jones JV, Oddis JA, Cohen JS, Insel PA. The American hospital formulary service information books beat the PDR [2] (multiple letters) Archives of Internal Medicine. 157: 575-579. PMID 9066464 |
0.01 |
|
| 1974 |
Insel PA, Kramer KJ, Sherwin RS, Liljenquist JE, Tobin JD, Andres R, Berman M. Modeling the insulin-glucose system in man. Federation Proceedings. 33: 1865-8. PMID 4834190 |
0.01 |
|
| 1971 |
INSEL P, WILSON GD. Measuring Social Attitudes in Children British Journal of Social and Clinical Psychology. 10: 84-86. DOI: 10.1111/J.2044-8260.1971.TB00717.X |
0.01 |
|
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