Louis J. DeFelice - Publications

Physiology and Biophysics Virginia Commonwealth University, Richmond, VA, United States 
serotonin (5HT), dopamine (DA), and norepinephrine (NE) transporters

102 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Fraser R, Chen Y, Guptaroy B, Luderman KD, Stokes SL, Beg A, DeFelice LJ, Gnegy ME. An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter. Molecular Pharmacology. 86: 76-85. PMID 24753048 DOI: 10.1124/mol.114.091926  1
2011 Chang JC, Tomlinson ID, Warnement MR, Iwamoto H, DeFelice LJ, Blakely RD, Rosenthal SJ. A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. Journal of the American Chemical Society. 133: 17528-31. PMID 21970724 DOI: 10.1021/ja204301g  1
2011 Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, et al. A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. The Journal of Biological Chemistry. 286: 30823-36. PMID 21730057 DOI: 10.1074/jbc.M111.250308  1
2011 Dale B, Defelice L. Polyspermy prevention: Facts and artifacts? Journal of Assisted Reproduction and Genetics. 28: 199-207. PMID 21104196 DOI: 10.1007/s10815-010-9513-5  1
2008 Carvelli L, Blakely RD, DeFelice LJ. Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 105: 14192-7. PMID 18768815 DOI: 10.1073/pnas.0802214105  1
2007 Blakely RD, DeFelice LJ. All aglow about presynaptic receptor regulation of neurotransmitter transporters. Molecular Pharmacology. 71: 1206-8. PMID 17329498 DOI: 10.1124/mol.107.035493  1
2007 DeFelice LJ, Goswami T. Transporters as channels. Annual Review of Physiology. 69: 87-112. PMID 17059369 DOI: 10.1146/annurev.physiol.69.031905.164816  1
2006 Schwartz JW, Piston D, DeFelice LJ. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of Experimental Pharmacology. 23-57. PMID 16722229 DOI: 10.1007/3-540-29784-7-2  1
2006 Henry LK, Defelice LJ, Blakely RD. Getting the message across: a recent transporter structure shows the way. Neuron. 49: 791-6. PMID 16543127 DOI: 10.1016/j.neuron.2006.03.002  1
2005 Blakely RD, Defelice LJ, Galli A. Biogenic amine neurotransmitter transporters: just when you thought you knew them. Physiology (Bethesda, Md.). 20: 225-31. PMID 16024510 DOI: 10.1152/physiol.00013.2005  1
2005 Mason JN, Farmer H, Tomlinson ID, Schwartz JW, Savchenko V, DeFelice LJ, Rosenthal SJ, Blakely RD. Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation. Journal of Neuroscience Methods. 143: 3-25. PMID 15763132 DOI: 10.1016/j.jneumeth.2004.09.028  1
2005 Schwartz JW, Novarino G, Piston DW, DeFelice LJ. Substrate binding stoichiometry and kinetics of the norepinephrine transporter. The Journal of Biological Chemistry. 280: 19177-84. PMID 15757904 DOI: 10.1074/jbc.M412923200  1
2004 Defelice LJ. Going against the flow. Nature. 432: 279. PMID 15549077 DOI: 10.1038/432279a  1
2004 Carvelli L, McDonald PW, Blakely RD, Defelice LJ. Dopamine transporters depolarize neurons by a channel mechanism. Proceedings of the National Academy of Sciences of the United States of America. 101: 16046-51. PMID 15520385 DOI: 10.1073/pnas.0403299101  1
2004 DeFelice LJ. Transporter structure and mechanism. Trends in Neurosciences. 27: 352-9. PMID 15165740 DOI: 10.1016/j.tins.2004.04.007  1
2004 Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. Plos Biology. 2: E50. PMID 15024413 DOI: 10.1371/journal.pbio.0020050  1
2003 Adams SV, DeFelice LJ. Ionic currents in the human serotonin transporter reveal inconsistencies in the alternating access hypothesis. Biophysical Journal. 85: 1548-59. PMID 12944272 DOI: 10.1016/S0006-3495(03)74587-1  1
2003 Schwartz JW, Blakely RD, DeFelice LJ. Binding and transport in norepinephrine transporters. Real-time, spatially resolved analysis in single cells using a fluorescent substrate. The Journal of Biological Chemistry. 278: 9768-77. PMID 12499385 DOI: 10.1074/jbc.M209824200  1
2002 Adams SV, DeFelice LJ. Flux coupling in the human serotonin transporter. Biophysical Journal. 83: 3268-82. PMID 12496095 DOI: 10.1016/S0006-3495(02)75328-9  1
2002 Rosenthal SJ, Tomlinson I, Adkins EM, Schroeter S, Adams S, Swafford L, McBride J, Wang Y, DeFelice LJ, Blakely RD. Targeting cell surface receptors with ligand-conjugated nanocrystals. Journal of the American Chemical Society. 124: 4586-94. PMID 11971705 DOI: 10.1021/ja003486s  1
2002 Jayanthi LD, Vargas G, DeFelice LJ. Characterization of cocaine and antidepressant-sensitive norepinephrine transporters in rat placental trophoblasts. British Journal of Pharmacology. 135: 1927-34. PMID 11959795 DOI: 10.1038/sj.bjp.0704658  1
2002 Ramsey IS, DeFelice LJ. Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor. The Journal of Biological Chemistry. 277: 14475-82. PMID 11844791 DOI: 10.1074/jbc.M110783200  1
2001 DeFelice LJ, Adams SV, Ypey DL. Single-file diffusion and neurotransmitter transporters: Hodgkin and Keynes model revisited. Bio Systems. 62: 57-66. PMID 11595319 DOI: 10.1016/S0303-2647(01)00137-X  1
2000 Jayanthi LD, Wilson JJ, Montalvo J, DeFelice LJ. Differential regulation of mammalian brain-specific proline transporter by calcium and calcium-dependent protein kinases. British Journal of Pharmacology. 129: 465-70. PMID 10711344 DOI: 10.1038/sj.bjp.0703071  1
2000 Defelice LJ. Linear analysis in non-linear systems: Signal-to-noise ratios in noisy neurons Chaos, Solitons and Fractals. 11: 1823-1826. DOI: 10.1016/S0960-0779(99)00197-6  1
1999 Galli A, Jayanthi LD, Ramsey IS, Miller JW, Fremeau RT, DeFelice LJ. L-proline and L-pipecolate induce enkephalin-sensitive currents in human embryonic kidney 293 cells transfected with the high-affinity mammalian brain L-proline transporter. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6290-7. PMID 10414958  1
1999 Petersen CI, DeFelice LJ. Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nature Neuroscience. 2: 605-10. PMID 10404179 DOI: 10.1038/10158  1
1998 Apparsundaram S, Galli A, DeFelice LJ, Hartzell HC, Blakely RD. Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells. The Journal of Pharmacology and Experimental Therapeutics. 287: 733-43. PMID 9808704  1
1998 Galli A, Blakely RD, DeFelice LJ. Patch-clamp and amperometric recordings from norepinephrine transporters: channel activity and voltage-dependent uptake. Proceedings of the National Academy of Sciences of the United States of America. 95: 13260-5. PMID 9789076 DOI: 10.1073/pnas.95.22.13260  1
1998 DeFelice LJ, Galli A. Fluctuation analysis of norepinephrine and serotonin transporter currents. Methods in Enzymology. 296: 578-93. PMID 9779475 DOI: 10.1016/S0076-6879(98)96041-4  1
1998 Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A, DeFelice LJ. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biological Psychiatry. 44: 169-78. PMID 9693389 DOI: 10.1016/S0006-3223(98)00124-3  1
1998 DeFelice LJ, Galli A. Electrophysiological analysis of transporter function. Advances in Pharmacology (San Diego, Calif.). 42: 186-90. PMID 9327875 DOI: 10.1016/S1054-3589(08)60724-3  1
1997 Galli A, Petersen CI, deBlaquiere M, Blakely RD, DeFelice LJ. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3401-11. PMID 9133366  1
1997 Qian Y, Galli A, Ramamoorthy S, Risso S, DeFelice LJ, Blakely RD. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 45-57. PMID 8987735  1
1996 DeFelice LJ. Release of secretory vesicle contents: regulation after fusion? Biophysical Journal. 71: 1163-4. PMID 8873989  1
1996 DeFelice LJ, Blakely RD. Pore models for transporters? Biophysical Journal. 70: 579-80. PMID 8789077  1
1996 Oleson DR, DeFelice LJ, Quinn MF, Donahoe RM. Cyclic adenosine 3',5'-monophosphate increases the open probability of potassium channels in activated human T cells. Journal of Immunology (Baltimore, Md. : 1950). 157: 1080-6. PMID 8757612  1
1996 Galli A, Blakely RD, DeFelice LJ. Norepinephrine transporters have channel modes of conduction. Proceedings of the National Academy of Sciences of the United States of America. 93: 8671-6. PMID 8710929 DOI: 10.1073/pnas.93.16.8671  1
1996 Risso S, DeFelice LJ, Blakely RD. Sodium-dependent GABA-induced currents in GAT1-transfected HeLa cells. The Journal of Physiology. 490: 691-702. PMID 8683468  1
1996 Machaca K, DeFelice LJ, L'Hernault SW. A novel chloride channel localizes to Caenorhabditis elegans spermatids and chloride channel blockers induce spermatid differentiation. Developmental Biology. 176: 1-16. PMID 8654886 DOI: 10.1006/dbio.1996.9999  1
1995 Galli A, DeFelice LJ, Duke BJ, Moore KR, Blakely RD. Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. The Journal of Experimental Biology. 198: 2197-212. PMID 7500004  1
1994 DeFelice LJ. Forum: how does a zygote become an embryo? Zygote (Cambridge, England). 2: 179. PMID 8785674  1
1994 Forsdyke DR, Rivera H, DeFelice LJ. Authorship and misconduct [1] Nature. 370: 91. PMID 8080527  1
1994 DeFelice LJ. Authorship and misconduct. Nature. 370: 91. PMID 8022491 DOI: 10.1038/370091c0  1
1994 Galli A, DeFelice LJ. Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol. Biophysical Journal. 67: 2296-304. PMID 7696470 DOI: 10.1016/S0006-3495(94)80715-5  1
1994 DeFelice LJ. How ATP regulates the CFT regulator. Biophysical Journal. 66: 1268-9. PMID 7520288  1
1994 Dale B, DeFelice LJ, Kyozuka K, Santella L, Tosti E. Voltage clamp of the nuclear envelope Proceedings of the Royal Society B: Biological Sciences. 255: 119-124.  1
1993 Oleson DR, DeFelice LJ, Donahoe RM. A comparison of K+ channel characteristics in human T cells: perforated-patch versus whole-cell recording techniques. The Journal of Membrane Biology. 132: 229-41. PMID 8492307 DOI: 10.1007/BF00235740  1
1993 Mattioli M, Barboni B, DeFelice LJ. Calcium and potassium currents in porcine granulosa cells maintained in follicular or monolayer tissue culture. The Journal of Membrane Biology. 134: 75-83. PMID 8393490 DOI: 10.1007/BF00233477  1
1993 DeFelice LJ. Molecular and biophysical view of the Ca channel: a hypothesis regarding oligomeric structure, channel clustering, and macroscopic current. The Journal of Membrane Biology. 133: 191-202. PMID 8392582 DOI: 10.1007/BF00232019  1
1993 DeFelice LJ. Gating currents. Machinery behind the molecule. Biophysical Journal. 64: 5-6. PMID 8381682  1
1993 Oleson DR, DeFelice LJ, Donahoe RM. Ethanol increases K+ conductance in human T-cells. Alcoholism, Clinical and Experimental Research. 17: 604-9. PMID 8333591  1
1993 Risso S, DeFelice LJ. Ca channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells. Biophysical Journal. 65: 1006-18. PMID 8241381 DOI: 10.1016/S0006-3495(93)81147-0  1
1993 Murnane JM, DeFelice LJ. Electrical maturation of the murine oocyte: an increase in calcium current coincides with acquisition of meiotic competence. Zygote (Cambridge, England). 1: 49-60. PMID 8081801  1
1993 DeFelice LJ, Isaac A. Chaotic states in a random world: Relationship between the nonlinear differential equations of excitability and the stochastic properties of ion channels Journal of Statistical Physics. 70: 339-354. DOI: 10.1007/BF01053972  1
1992 Liu YM, DeFelice LJ, Mazzanti M. Na channels that remain open throughout the cardiac action potential plateau. Biophysical Journal. 63: 654-62. PMID 1330034 DOI: 10.1016/S0006-3495(92)81635-1  1
1991 Dale B, Talevi R, DeFelice LJ. L-type Ca2+ currents in ascidian eggs. Experimental Cell Research. 192: 302-6. PMID 1845798 DOI: 10.1016/0014-4827(91)90190-6  1
1991 Mazzanti M, DeFelice LJ, Smith EF. Ion channels in murine nuclei during early development and in fully differentiated adult cells. The Journal of Membrane Biology. 121: 189-98. PMID 1715405 DOI: 10.1007/BF01870532  1
1991 Mazzanti M, DeFelice LJ, Liu YM. Gating of L-type Ca2+ channels in embryonic chick ventricle cells: dependence on voltage, current and channel density. The Journal of Physiology. 443: 307-34. PMID 1668339  0.52
1991 DeFelice LJ. Activity of ion channels during action potentials Annals of Biomedical Engineering. 19: 617.  1
1990 DeFelice LJ, Goolsby WN, Mazzanti M. Potassium channels and the repolarization of cardiac cells. Annals of the New York Academy of Sciences. 588: 174-84. PMID 2357017 DOI: 10.1111/j.1749-6632.1990.tb13208.x  1
1990 Mazzanti M, DeFelice LJ, Cohn J, Malter H. Ion channels in the nuclear envelope. Nature. 343: 764-7. PMID 2304551 DOI: 10.1038/343764a0  1
1990 Iwasa KH, Ehrenstein G, DeFelice LJ, Russell JT. High concentration of inositol 1,4,5-trisphosphate in sea urchin sperm. Biochemical and Biophysical Research Communications. 172: 932-8. PMID 2241981 DOI: 10.1016/0006-291X(90)90765-F  1
1990 Mazzanti M, DeFelice LJ. Ca channel gating during cardiac action potentials. Biophysical Journal. 58: 1059-65. PMID 2174270 DOI: 10.1016/S0006-3495(90)82448-6  1
1990 Mazzanti M, DeFelice LJ. Ca modulates outward current through IK1 channels. The Journal of Membrane Biology. 116: 41-5. PMID 2165175 DOI: 10.1007/BF01871670  1
1990 Wellis DP, DeFelice LJ, Mazzanti M. Outward sodium current in beating heart cells. Biophysical Journal. 57: 41-8. PMID 2153421 DOI: 10.1016/S0006-3495(90)82505-4  1
1988 Mazzanti M, DeFelice LJ. K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells. Biophysical Journal. 54: 1139-48. PMID 3233269 DOI: 10.1016/S0006-3495(88)83048-0  1
1988 Kell MJ, DeFelice LJ. Surface charge near the cardiac inward-rectifier channel measured from single-channel conductance. The Journal of Membrane Biology. 102: 1-10. PMID 2456392 DOI: 10.1007/BF01875348  1
1987 DeFelice LJ, Kell MJ. Sperm-activated currents in ascidian oocytes. Developmental Biology. 119: 123-8. PMID 3792625 DOI: 10.1016/0012-1606(87)90213-2  1
1987 Mazzanti M, DeFelice LJ. Na channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells. Biophysical Journal. 52: 95-100. PMID 2440494 DOI: 10.1016/S0006-3495(87)83192-2  1
1987 Mazzanti M, DeFelice LJ. Regulation of the Na-conducting Ca channel during the cardiac action potential. Biophysical Journal. 51: 115-21. PMID 2432951 DOI: 10.1016/S0006-3495(87)83316-7  1
1986 DeFelice LJ, Dale B, Talevi R. Distribution of fertilization channels in ascidian oocyte membranes. Proceedings of the Royal Society of London. Series B, Biological Sciences. 229: 209-14. PMID 2433696  1
1986 Levi R, DeFelice LJ. Sodium-conducting channels in cardiac membranes in low calcium. Biophysical Journal. 50: 5-9. PMID 2425858 DOI: 10.1016/S0006-3495(86)83433-6  1
1985 Kell MJ, DeFelice LJ, Goolsby W. Equilibrium energy analysis of freeze-fracture planes in membranes. Journal of Theoretical Biology. 115: 103-27. PMID 4033160 DOI: 10.1016/S0022-5193(85)80009-6  1
1985 Dale B, DeFelice LJ, Ehrenstein G. Injection of a soluble sperm fraction into sea-urchin eggs triggers the cortical reaction. Experientia. 41: 1068-70. PMID 4018233 DOI: 10.1007/BF01952148  1
1984 Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. Biophysical Journal. 45: 40-2. PMID 19431556  1
1984 Fischmeister R, DeFelice LJ, Ayer RK, Levi R, DeHaan RL. Channel currents during spontaneous action potentials in embryonic chick heart cells. The action potential patch clamp. Biophysical Journal. 46: 267-71. PMID 6089925 DOI: 10.1016/S0006-3495(84)84020-5  1
1983 Clay JR, DeFelice LJ. Relationship between membrane excitability and single channel open-close kinetics. Biophysical Journal. 42: 151-7. PMID 6305436 DOI: 10.1016/S0006-3495(83)84381-1  1
1982 Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. The Journal of Membrane Biology. 67: 63-71. PMID 7097756 DOI: 10.1007/BF01868648  1
1981 Lindemann B, DeFelice LJ. On the use of general network functions in the evaluation of noise spectra obtained from epithelia. Society of General Physiologists Series. 36: 1-13. PMID 6269225  1
1979 DeFelice LJ, Dale B. Voltage response to fertilization and polyspermy in sea urchin eggs and oocytes. Developmental Biology. 72: 327-41. PMID 510790 DOI: 10.1016/0012-1606(79)90122-2  1
1979 Clay JR, DeFelice LJ, DeHaan RL. Current noise parameters derived from voltage noise and impedance in embryonic heart cell aggregates. Biophysical Journal. 28: 169-84. PMID 262547 DOI: 10.1016/S0006-3495(79)85169-3  1
1978 De Haan RL, DeFelice LJ. Electrical noise and rhythmic properties of embryonic heart cell aggregates. Federation Proceedings. 37: 2132-8. PMID 566220  1
1977 DeFelice LJ, Alkon DL. Voltage noise from hair cells during mechanical stimulation. Nature. 269: 613-5. PMID 917109 DOI: 10.1038/269613a0  1
1977 DeFelice LJ. Fluctuation analysis in neurobiology. International Review of Neurobiology. 20: 169-208. PMID 304052  1
1977 DeFelice LJ, DeHaan RL. Membrane noise and intercellular communication Proceedings of the Ieee. 65: 796-799. DOI: 10.1109/PROC.1977.10562  1
1976 DeFelice LJ, Sokol BA. A new analysis for membrane noise. The integral spectrum. Biophysical Journal. 16: 827-38. PMID 938721 DOI: 10.1016/S0006-3495(76)85731-1  1
1976 DeFelice LJ, Sokol BA. Letters to the editor: Correlation analysis of membrane noise. The Journal of Membrane Biology. 26: 405-7. PMID 933153  1
1976 DeFelice LJ. 1/f resistor noise Journal of Applied Physics. 47: 350-352. DOI: 10.1063/1.322324  1
1976 DeFelice LJ, Sokol BA. Correlation analysis of membrane noise The Journal of Membrane Biology. 26: 405-406. DOI: 10.1007/BF01868886  1
1975 DeFelice LJ, Wanke E, Conti F. Potassium and sodium current noise from squid axon membranes. Federation Proceedings. 34: 1338-42. PMID 1123089  1
1975 DeFelice LJ, DeHaan RL. Voltage noise and impedance from heart cell aggregates Biophysical Journal. 15: 130A.  1
1974 Verveen AA, DeFelice LJ. Membrane noise. Progress in Biophysics and Molecular Biology. 28: 189-265. PMID 4617247 DOI: 10.1016/0079-6107(74)90019-4  1
1974 Wanke E, DeFelice LJ, Conti F. Voltage noise, current noise and impedance in space clamped squid giant axon. PflüGers Archiv : European Journal of Physiology. 347: 63-74. PMID 4407444 DOI: 10.1007/BF00587055  1
1974 DeFelice LJ, Wanke E, Conti F. K and Na current noise in nerve membrane Federation Proceedings. 33: no. 655.  1
1973 Michalides JP, Wallaart RA, DeFelice LJ. Electrical noise from PVC-membranes. PflüGers Archiv : European Journal of Physiology. 341: 97-104. PMID 4738376 DOI: 10.1007/BF00587316  1
1972 Defelice LJ, Michalides JP. Electrical noise from synthetic membranes. The Journal of Membrane Biology. 9: 261-90. PMID 24177652 DOI: 10.1007/BF01868056  1
1972 DeFelice LJ, Michalides JP. Electrical noise from synthetic membranes. Biomembranes. 3: 293-8. PMID 4666513  1
1972 Bourne JR, Fox R, DeFelice LJ, Michalides JPLM, Blair WD, Gilliland BE, Murray JM, Hiatt CF, Chenette ER, King GE, Magin RL, Burns CP. IEEE REGION 3 CONVENTION, SOUTHEASTCON 1972, PROCEEDINGS OF THE 10TH ANNUAL: SCANNING THE SPECTRUM 1
1971 DeFelice LJ, Firth DR. Spontaneous voltage fluctuations in glass microelectrodes. Ieee Transactions On Bio-Medical Engineering. 18: 339-51. PMID 5564366 DOI: 10.1109/TBME.1971.4502865  1
1971 Firth DR, DeFelice LJ. Electrical resistance and volume flow in glass microelectrodes. Canadian Journal of Physiology and Pharmacology. 49: 436-47. PMID 5120271  1
1969 DeFelice LJ, Challice CE. Anatomical and ultrastructural study of the electrophysiological atrioventricular node of the rabbit. Circulation Research. 24: 457-74. PMID 5766521  1
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