| Year |
Citation |
Score |
| 2021 |
Paudyal MP, Wang M, Siitonen JH, Hu Y, Yousufuddin M, Shen HC, Falck JR, Kürti L. Intramolecular N-Me and N-H aminoetherification for the synthesis of -unprotected 3-amino-O-heterocycles. Organic & Biomolecular Chemistry. PMID 33399609 DOI: 10.1039/d0ob02122a |
0.571 |
|
| 2020 |
Hu Y, Shi H, Zhou M, Ren Q, Zhu W, Zhang W, Zhang Z, Zhou C, Liu Y, Ding X, Shen HC, Yan SF, Dey F, Wu W, Zhai G, et al. Discovery of Pyrido[2,3-b]indole Derivatives with Gram-negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. Journal of Medicinal Chemistry. PMID 32787097 DOI: 10.1021/Acs.Jmedchem.0C00768 |
0.532 |
|
| 2020 |
Liu Y, Wu J, Zhou M, Chen W, Li D, Wang ZG, Hornsperger B, Aebi JD, Märki HP, Kuhn B, Wang L, Kuglstatter A, Benz J, Müller S, Hochstrasser R, ... ... Shen HC, et al. Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors. Journal of Medicinal Chemistry. PMID 32530624 DOI: 10.1021/Acs.Jmedchem.0C00233 |
0.316 |
|
| 2020 |
Wang D, Liu Y, Zhu W, Shen H, Liu H, Fu L. Efficient Synthesis of Substituted Morpholine Derivatives via an Indium(III)-catalyzed Reductive Etherification Reaction Chemistry Letters. 49: 709-712. DOI: 10.1246/Cl.200142 |
0.422 |
|
| 2020 |
Wu J, Zhang H, Ding X, Tan X, Shen HC, Chen J, Song L, Cao W. Efficient synthesis of perfluoroalkylated quinolines via a metal-free cascade Michael addition/intramolecular rearrangement cyclization process Tetrahedron. 76: 131518. DOI: 10.1016/J.Tet.2020.131518 |
0.387 |
|
| 2019 |
Zheng X, Liang C, Wang L, Miao K, Wang B, Zhang W, Chen D, Wu G, Zhu W, Guo L, Feng S, Gao L, Shen HC, Yun H. Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors. Medchemcomm. 10: 970-973. PMID 31303995 DOI: 10.1039/C9Md00178F |
0.322 |
|
| 2019 |
Wu J, Zhang H, Ding X, Tan X, Shen HC, Chen J, He W, Deng H, Song L, Cao W. Facile synthesis of fluoroalkylated quinolones using fluoroalk-2-ynoates as fluorinated building blocks Journal of Fluorine Chemistry. 220: 54-60. DOI: 10.1016/J.Jfluchem.2019.02.002 |
0.398 |
|
| 2018 |
Zheng X, Liang C, Wang L, Wang B, Liu Y, Feng S, Wu JZ, Gao L, Feng L, Chen L, Guo T, Shen HC, Yun H. Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors. Journal of Medicinal Chemistry. PMID 30339388 DOI: 10.1021/Acs.Jmedchem.8B01394 |
0.3 |
|
| 2018 |
Wu J, Zhang H, Ding X, Tan X, Chen J, He W, Deng H, Song L, Shen HC, Cao W. Potassium iodide promoted one-pot synthesis of fluoroalkylated quinoxalines via a tandem Michael addition / azidation / cycloamination approach. The Journal of Organic Chemistry. PMID 30025451 DOI: 10.1021/Acs.Joc.8B01030 |
0.377 |
|
| 2018 |
Zhou M, Tan X, Hu Y, Shen HC, Qian X. Highly Chemo- and Regioselective Vinylation of N-Heteroarenes with Vinylsulfonium Salts. The Journal of Organic Chemistry. PMID 29799743 DOI: 10.1021/Acs.Joc.8B00682 |
0.599 |
|
| 2018 |
Feng S, Gao L, Han X, Hu T, Hu Y, Liu H, Thomas AW, Yan Z, Yang S, Young JAT, Yun H, Zhu W, Shen HC. Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection. Acs Infectious Diseases. PMID 29369612 DOI: 10.1021/Acsinfecdis.7B00144 |
0.507 |
|
| 2018 |
Zhou M, Hu Y, En K, Tan X, Shen HC, Qian X. Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate Tetrahedron Letters. 59: 1443-1445. DOI: 10.1016/J.Tetlet.2018.02.080 |
0.358 |
|
| 2017 |
Lu C, Lu H, Wu J, Shen HC, Hu T, Gu Y, Shen Q. Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules. The Journal of Organic Chemistry. PMID 29271195 DOI: 10.1021/Acs.Joc.7B02989 |
0.35 |
|
| 2017 |
Cheng Z, Yu Z, Yang S, Shen HC, Zhao W, Zhong S. C-H Bond Functionalization of Tetrahydropyridopyrimidines and Other Related Hetereocycles. The Journal of Organic Chemistry. PMID 29134810 DOI: 10.1021/Acs.Joc.7B02382 |
0.316 |
|
| 2017 |
Feng S, Li C, Chen D, Zheng X, Yun H, Gao L, Shen HC. Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors. European Journal of Medicinal Chemistry. 138: 1147-1157. PMID 28772235 DOI: 10.1016/J.Ejmech.2017.07.032 |
0.307 |
|
| 2017 |
Qiu Z, Lin X, Zhang W, Zhou M, Guo L, Kocer B, Wu G, Zhang Z, Liu H, Shi H, Kou B, Hu T, Hu Y, Huang M, Yan SF, ... ... Shen HC, et al. Discovery and Pre-Clinical Characterization of a 3(rd) Generation 4-H HeteroAryldihydroPyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors. Journal of Medicinal Chemistry. PMID 28339215 DOI: 10.1021/Acs.Jmedchem.7B00083 |
0.556 |
|
| 2017 |
Zhou M, En K, Hu Y, Xu Y, Shen HC, Qian X. Zinc triflate-mediated cyclopropanation of oxindoles with vinyl diphenyl sulfonium triflate: a mild reaction with broad functional group compatibility Rsc Advances. 7: 3741-3745. DOI: 10.1039/C6Ra24985J |
0.371 |
|
| 2017 |
Wang J, Zhang J, Miao K, Yun H, Shen HC, Zhao W, Liang C. Eaton’s reagent-mediated metal-free and efficient synthesis of NH-sulfoximines Tetrahedron Letters. 58: 333-337. DOI: 10.1016/J.Tetlet.2016.12.031 |
0.348 |
|
| 2016 |
Zheng X, Wang L, Wang B, Miao K, Xiang K, Feng S, Gao L, Shen HC, Yun H. Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors. Acs Medicinal Chemistry Letters. 7: 558-62. PMID 27326326 DOI: 10.1021/Acsmedchemlett.5B00234 |
0.313 |
|
| 2016 |
Wang M, Hu Y, Jiang Z, Shen HC, Sun X. Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization. Organic & Biomolecular Chemistry. PMID 27073988 DOI: 10.1039/c6ob00392c |
0.573 |
|
| 2016 |
Dong Q, Shen HC, Jiang M. Efficient synthesis of functionalized chromones via a two-base mediated formal [3+3] cycloaddition Tetrahedron Letters. 57: 2116-2120. DOI: 10.1016/J.Tetlet.2016.04.010 |
0.36 |
|
| 2016 |
Girling PR, Batsanov AS, Calow ADJ, Shen HC, Whiting A. Alternative tandem cyclisation pathways in the reaction between imines and enones Tetrahedron. 72. DOI: 10.1016/J.Tet.2016.01.006 |
0.389 |
|
| 2015 |
Feng S, Hong D, Wang B, Zheng X, Miao K, Wang L, Yun H, Gao L, Zhao S, Shen HC. Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors. Acs Medicinal Chemistry Letters. 6: 359-62. PMID 25941547 DOI: 10.1021/Acsmedchemlett.5B00008 |
0.303 |
|
| 2014 |
Batsanov AS, Georgiou I, Girling PR, Pommier L, Shen HC, Whiting A. Asymmetric synthesis and application of homologous pyrroline-2-alkylboronic acids: Identification of the B-N distance for eliciting bifunctional catalysis of an asymmetric aldol reaction. Asian Journal of Organic Chemistry. 3: 470-479. DOI: 10.1002/Ajoc.201300127 |
0.386 |
|
| 2013 |
Shen HC, Graham TH. Gold-catalyzed formation of heterocycles - an enabling new technology for medicinal chemistry. Drug Discovery Today. Technologies. 10: e3-14. PMID 24050224 DOI: 10.1016/J.Ddtec.2012.10.014 |
0.372 |
|
| 2013 |
Vandavasi JK, Kuo KK, Hu WP, Shen HC, Lo WS, Wang JJ. A convenient method to construct (Z)-oxazines via 6-exo-dig iodocyclization and synthesis of indolin-3-one. Organic & Biomolecular Chemistry. 11: 6520-5. PMID 23963094 DOI: 10.1039/c3ob41272e |
0.374 |
|
| 2012 |
Girling PR, Batsanov AS, Shen HC, Whiting A. A multicomponent formal [1+2+1+2]-cycloaddition for the synthesis of dihydropyridines. Chemical Communications (Cambridge, England). 48: 4893-5. PMID 22499258 DOI: 10.1039/C2Cc31495A |
0.466 |
|
| 2012 |
Shen HC, Hammock BD. Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications. Journal of Medicinal Chemistry. 55: 1789-808. PMID 22168898 DOI: 10.1021/Jm201468J |
0.337 |
|
| 2012 |
Wu G, Yin W, Shen HC, Huang Y. One-pot synthesis of useful heterocycles in medicinal chemistry using a cascade strategy Green Chemistry. 14: 580-585. DOI: 10.1039/C2Gc16457D |
0.411 |
|
| 2010 |
Trost BM, Shen HC, Pinkerton AB. ChemInform Abstract: A Synthesis of Trisubstituted Alkenes by a Ru-Catalyzed Addition. Cheminform. 33: no-no. DOI: 10.1002/chin.200241072 |
0.485 |
|
| 2010 |
Trost BM, Shen HC. ChemInform Abstract: Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular [5 + 2] Cycloaddition. Cheminform. 32: no-no. DOI: 10.1002/chin.200142125 |
0.437 |
|
| 2010 |
Trost BM, Toste FD, Shen H. ChemInform Abstract: Ruthenium-Catalyzed Intramolecular [5 + 2] Cycloadditions. Cheminform. 31: no-no. DOI: 10.1002/chin.200023040 |
0.615 |
|
| 2009 |
Shen HC, Ding FX, Deng Q, Xu S, Tong X, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Roy S, Zhang B, Tata JR, Berger JP, Colletti SL. A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5716-21. PMID 19700315 DOI: 10.1016/J.Bmcl.2009.08.006 |
0.305 |
|
| 2009 |
Shen HC, Ding FX, Deng Q, Xu S, Chen HS, Tong X, Tong V, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Zhang B, Roy S, Tata JR, et al. Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5314-20. PMID 19682899 DOI: 10.1016/J.Bmcl.2009.07.138 |
0.306 |
|
| 2009 |
Shen HC, Ding FX, Wang S, Xu S, Chen HS, Tong X, Tong V, Mitra K, Kumar S, Zhang X, Chen Y, Zhou G, Pai LY, Alonso-Galicia M, Chen X, et al. Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 3398-404. PMID 19481932 DOI: 10.1016/J.Bmcl.2009.05.036 |
0.313 |
|
| 2009 |
Shen HC, Ding FX, Singh SB, Parthasarathy G, Soisson SM, Ha SN, Chen X, Kodali S, Wang J, Dorso K, Tata JR, Hammond ML, Maccoss M, Colletti SL. Synthesis and biological evaluation of platensimycin analogs. Bioorganic & Medicinal Chemistry Letters. 19: 1623-7. PMID 19233644 DOI: 10.1016/J.Bmcl.2009.02.006 |
0.317 |
|
| 2009 |
Yang DX, Colletti SL, Wu K, Song M, Li GY, Shen HC. Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands. Organic Letters. 11: 381-4. PMID 19072215 DOI: 10.1021/Ol802642G |
0.383 |
|
| 2009 |
Shen HC. Asymmetric synthesis of chiral chromans Tetrahedron. 65: 3931-3952. DOI: 10.1016/J.Tet.2009.02.002 |
0.332 |
|
| 2008 |
Shen HC. Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions Tetrahedron. 64: 7847-7870. DOI: 10.1016/J.Tet.2008.05.082 |
0.385 |
|
| 2008 |
Shen HC. Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes Tetrahedron. 64: 3885-3903. DOI: 10.1016/J.Tet.2008.01.081 |
0.404 |
|
| 2007 |
Minnihan EC, Colletti SL, Toste FD, Shen HC. Gold(I)-catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes. The Journal of Organic Chemistry. 72: 6287-9. PMID 17625890 DOI: 10.1021/Jo071014R |
0.62 |
|
| 2006 |
Shen HC, Ding FX, Colletti SL. Alpha-heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution. Organic Letters. 8: 1447-50. PMID 16562913 DOI: 10.1021/Ol060246U |
0.337 |
|
| 2005 |
Trost BM, Shen HC, Horne DB, Toste FD, Steinmetz BG, Koradin C. Syntheses of seven-membered rings: ruthenium-catalyzed intramolecular [5+2] cycloadditions. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 2577-90. PMID 15736147 DOI: 10.1002/Chem.200401065 |
0.737 |
|
| 2004 |
Trost BM, Shen HC, Surivet JP. Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations. Journal of the American Chemical Society. 126: 12565-79. PMID 15453789 DOI: 10.1021/Ja048084P |
0.539 |
|
| 2004 |
Trost BM, Shen HC, Dong L, Surivet JP, Sylvain C. Synthesis of chiral chromans by the Pd-catalyzed asymmetric allylic alkylation (AAA): scope, mechanism, and applications. Journal of the American Chemical Society. 126: 11966-83. PMID 15382932 DOI: 10.1021/Ja048078T |
0.534 |
|
| 2003 |
Trost BM, Shen HC, Schulz T, Koradin C, Schirok H. On the diastereoselectivity of ru-catalyzed [5 + 2] cycloadditions. Organic Letters. 5: 4149-51. PMID 14572271 DOI: 10.1021/Ol0355884 |
0.557 |
|
| 2003 |
Trost BM, Shen HC, Surivet JP. An enantioselective biomimetic total synthesis of (-)-siccanin. Angewandte Chemie (International Ed. in English). 42: 3943-7. PMID 12949876 DOI: 10.1002/Anie.200351868 |
0.491 |
|
| 2003 |
Trost BM, Shen HC, Dong L, Surivet JP. Unusual effects in the pd-catalyzed asymmetric allylic alkylations: synthesis of chiral chromans. Journal of the American Chemical Society. 125: 9276-7. PMID 12889940 DOI: 10.1021/Ja036052G |
0.52 |
|
| 2003 |
Shen HC, Wang J, Cole KP, McLaughlin MJ, Morgan CD, Douglas CJ, Hsung RP, Coverdale HA, Gerasyuto AI, Hahn JM, Liu J, Sklenicka HM, Wei LL, Zehnder LR, Zificsak CA. A formal [3 + 3] cycloaddition reaction. Improved reactivity using alpha,beta-unsaturated iminium salts and evidence for reversibility of 6pi-electron electrocyclic ring closure of 1-oxatrienes. The Journal of Organic Chemistry. 68: 1729-35. PMID 12608785 DOI: 10.1021/Jo020688T |
0.614 |
|
| 2002 |
Trost BM, Shen HC, Pinkerton AB. A synthesis of trisubstituted alkenes by a Ru-catalyzed addition. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 2341-9. PMID 12012418 DOI: 10.1002/1521-3765(20020517)8:10<2341::Aid-Chem2341>3.0.Co;2-A |
0.703 |
|
| 2001 |
Trost BM, Shen HC. Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular [5+2] Cycloaddition. Angewandte Chemie (International Ed. in English). 40: 2313-2316. PMID 29711821 DOI: 10.1002/1521-3773(20010618)40:12<2313::Aid-Anie2313>3.0.Co;2-H |
0.523 |
|
| 2001 |
Zehnder LR, Wei LL, Hsung RP, Cole KP, McLaughlin MJ, Shen HC, Sklenicka HM, Wang J, Zificsak CA. Stereoselective trans- and cis-dihydroxylations of 2H-pyranyl and dihydropyridinyl heterocycles synthesized from formal [3 + 3]-cycloaddition reactions of alpha,beta-unsaturated iminium ions with 1,3-dicarbonyl equivalents. Organic Letters. 3: 2141-4. PMID 11440564 DOI: 10.1021/Ol010034R |
0.597 |
|
| 2001 |
Trost BM, Shen HC. Constructing Tricyclic Compounds Containing a Seven-Membered Ring by Ruthenium-Catalyzed Intramolecular Angewandte Chemie (International Ed. in English). 40: 2313-2316. PMID 11433506 DOI: 10.1002/1521-3773(20010618)40:12<2313::AID-ANIE2313>3.0.CO;2-H |
0.418 |
|
| 2001 |
McLaughlin MJ, Shen HC, Hsung RP. Chiral cycloalkylidene α,β-unsaturated iminium approach to stereoselective formal [3+3] cycloaddition reaction in spiroheterocycle synthesis Tetrahedron Letters. 42: 609-613. DOI: 10.1016/S0040-4039(00)02018-9 |
0.606 |
|
| 2000 |
Trost BM, Shen HC. On the regioselectivity of the Ru-catalyzed intramolecular [5 + 2] cycloaddition. Organic Letters. 2: 2523-5. PMID 10956537 DOI: 10.1021/Ol0061945 |
0.505 |
|
| 2000 |
Trost BM, Toste FD, Shen H. Ruthenium-Catalyzed Intramolecular [5 + 2] Cycloadditions Journal of the American Chemical Society. 122: 2379-2380. DOI: 10.1021/Ja993400Z |
0.584 |
|
| 2000 |
Trost BM, Shen HC. ChemInform Abstract: Regioselectivity of the Ru-Catalyzed Intramolecular [5 + 2] Cycloaddition. Cheminform. 31: no-no. DOI: 10.1002/chin.200044080 |
0.5 |
|
| 1999 |
Hsung RP, Shen HC, Douglas CJ, Morgan CD, Degen SJ, Yao LJ. Sequential 1,2-Addition-Electrocyclic Ring Closures Involving Acyclic alpha,beta-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles. The Journal of Organic Chemistry. 64: 690-691. PMID 11674130 DOI: 10.1021/Jo982165K |
0.536 |
|
| 1999 |
Degen SJ, Mueller KL, Shen HC, Mulder JA, Golding GM, Wei LL, Zificsak CA, Neeno-Eckwall A, Hsung RP. Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin. Bioorganic & Medicinal Chemistry Letters. 9: 973-8. PMID 10230623 DOI: 10.1016/S0960-894X(99)00115-8 |
0.564 |
|
| 1999 |
Douglas CJ, Sklenicka HM, Shen HC, Mathias DS, Degen SJ, Golding GM, Morgan CD, Shih RA, Mueller KL, Seurer LM, Johnson EW, Hsung RP. Synthesis and UV studies of a small library of 6-aryl-4-hydroxy-2- pyrones. A relevant structural feature for the inhibitory property of arisugacin against acetylcholinesterase Tetrahedron. 55: 13683-13696. DOI: 10.1016/S0040-4020(99)00847-9 |
0.584 |
|
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