Year |
Citation |
Score |
2022 |
Schapiro HM, Khasnis MD, Ahn K, Karagiaridi A, Hayden S, Cilento ME, Root MJ. Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env. Plos Pathogens. 18: e1010531. PMID 35584191 DOI: 10.1371/journal.ppat.1010531 |
0.552 |
|
2021 |
Zhang S, Holmes AP, Dick A, Rashad AA, Enríquez Rodríguez L, Canziani GA, Root MJ, Chaiken IM. Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators. Retrovirology. 18: 31. PMID 34627310 DOI: 10.1186/s12977-021-00575-z |
0.631 |
|
2019 |
Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ, Kay MS. Characterization of resistance to a potent D-peptide HIV entry inhibitor. Retrovirology. 16: 28. PMID 31640718 DOI: 10.1186/S12977-019-0489-7 |
0.535 |
|
2017 |
Ahn KW, Root MJ. Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors. The Journal of Biological Chemistry. PMID 28696261 DOI: 10.1074/jbc.M117.791731 |
0.468 |
|
2016 |
Khasnis MD, Halkidis K, Bhardwaj A, Root MJ. Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer. Plos Pathogens. 12: e1006098. PMID 27992602 DOI: 10.1371/journal.ppat.1006098 |
0.65 |
|
2016 |
Leslie GJ, Wang J, Richardson MW, Haggarty BS, Hua KL, Duong J, Secreto AJ, Jordon AP, Romano J, Kumar KE, DeClercq JJ, Gregory PD, June CH, Root MJ, Riley JL, et al. Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus. Plos Pathogens. 12: e1005983. PMID 27855210 DOI: 10.1371/Journal.Ppat.1005983 |
0.634 |
|
2016 |
Danial M, Stauffer A, Wurm FR, Root MJ, Klok HA. Site-specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates rather than Binding Affinity. Bioconjugate Chemistry. PMID 27737540 DOI: 10.1021/acs.bioconjchem.6b00540 |
0.511 |
|
2015 |
Rosemary Bastian A, Nangarlia A, Bailey LD, Holmes A, Kalyana Sundaram RV, Ang C, Moreira DR, Freedman K, Duffy C, Contarino M, Abrams C, Root M, Chaiken I. Mechanism of multivalent nanoparticle encounter with HIV-1 for potency enhancement of peptide triazole virus inactivation. The Journal of Biological Chemistry. 290: 529-43. PMID 25371202 DOI: 10.1074/Jbc.M114.608315 |
0.547 |
|
2012 |
Danial M, Root MJ, Klok HA. Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors. Biomacromolecules. 13: 1438-47. PMID 22455441 DOI: 10.1021/bm300150q |
0.479 |
|
2010 |
Welch BD, Francis JN, Redman JS, Paul S, Weinstock MT, Reeves JD, Lie YS, Whitby FG, Eckert DM, Hill CP, Root MJ, Kay MS. Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance. Journal of Virology. 84: 11235-44. PMID 20719956 DOI: 10.1128/Jvi.01339-10 |
0.573 |
|
2009 |
Kahle KM, Steger HK, Root MJ. Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding. Plos Pathogens. 5: e1000674. PMID 19956769 DOI: 10.1371/journal.ppat.1000674 |
0.715 |
|
2009 |
Champagne K, Shishido A, Root MJ. Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil. The Journal of Biological Chemistry. 284: 3619-27. PMID 19073602 DOI: 10.1074/jbc.M809269200 |
0.391 |
|
2008 |
Lederman MM, Jump R, Pilch-Cooper HA, Root M, Sieg SF. Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection. Retrovirology. 5: 116-116. PMID 19094217 DOI: 10.1186/1742-4690-5-116 |
0.468 |
|
2007 |
Sugaya M, Hartley O, Root MJ, Blauvelt A. C34, a membrane fusion inhibitor, blocks HIV infection of langerhans cells and viral transmission to T cells. The Journal of Investigative Dermatology. 127: 1436-43. PMID 17255952 DOI: 10.1038/sj.jid.5700736 |
0.42 |
|
2006 |
Steger HK, Root MJ. Kinetic dependence to HIV-1 entry inhibition. The Journal of Biological Chemistry. 281: 25813-21. PMID 16803885 DOI: 10.1074/jbc.M601457200 |
0.526 |
|
2004 |
Root MJ, Steger HK. HIV-1 gp41 as a target for viral entry inhibition. Current Pharmaceutical Design. 10: 1805-25. PMID 15180542 |
0.604 |
|
2003 |
Root MJ, Hamer DH. Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein. Proceedings of the National Academy of Sciences of the United States of America. 100: 5016-21. PMID 12702763 DOI: 10.1073/pnas.0936926100 |
0.564 |
|
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