Scott R. Whittemore - Publications

Affiliations: 
Neurological Surgery University of Louisville, Louisville, KY, United States 

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Shepard CT, Pocratsky AM, Brown BL, Van Rijswijck MA, Zalla RM, Burke DA, Morehouse JR, Riegler AS, Whittemore SR, Magnuson DS. Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat. Elife. 10. PMID 34854375 DOI: 10.7554/eLife.70058  0.751
2021 Slomnicki LP, Wei G, Burke DA, Hodges ER, Myers SA, Yarberry CD, Morehouse JR, Whittemore SR, Saraswat Ohri S, Hetman M. Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day. Plos One. 16: e0249981. PMID 34813603 DOI: 10.1371/journal.pone.0249981  0.492
2021 Wei GZ, Saraswat Ohri S, Khattar NK, Listerman AW, Doyle CH, Andres KR, Karuppagounder SS, Ratan RR, Whittemore SR, Hetman M. Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery. Plos One. 16: e0249591. PMID 33819286 DOI: 10.1371/journal.pone.0249591  0.406
2020 Saraswat Ohri S, Burke D, Andres K, Hetman M, Whittemore SR. Acute neural and proteostasis mRNA levels predict chronic locomotor recovery after contusive spinal cord injury. Journal of Neurotrauma. PMID 33076743 DOI: 10.1089/neu.2020.7258  0.301
2020 Saraswat Ohri S, Howard RM, Liu Y, Andres KR, Shepard CT, Hetman M, Whittemore SR. Oligodendrocyte-specific deletion of Xbp1 exacerbates the endoplasmic reticulum stress response and restricts locomotor recovery after thoracic spinal cord injury. Glia. PMID 32926479 DOI: 10.1002/glia.23907  0.393
2020 Pocratsky AM, Shepard CT, Morehouse JR, Burke DA, Riegler AS, Hardin JT, Beare JE, Hainline C, States GJ, Brown BL, Whittemore SR, Magnuson DS. Long ascending propriospinal neurons provide flexible, context-specific control of interlimb coordination. Elife. 9. PMID 32902379 DOI: 10.7554/eLife.53565  0.654
2020 Slomnicki LP, Myers SA, Saraswat Ohri S, Parsh MV, Andres KR, Chariker JH, Rouchka EC, Whittemore SR, Hetman M. Improved locomotor recovery after contusive spinal cord injury in Bmal1 mice is associated with protection of the blood spinal cord barrier. Scientific Reports. 10: 14212. PMID 32848194 DOI: 10.1038/S41598-020-71131-6  0.51
2020 Chariker JH, Sharp M, Ohri SS, Gomes C, Brabazon F, Harman KA, Whittemore SR, Petruska JC, Magnuson DS, Rouchka EC. RNA-seq data of soleus muscle tissue after spinal cord injury under conditions of inactivity and applied exercise. Data in Brief. 28: 105056. PMID 32226812 DOI: 10.1016/J.Dib.2019.105056  0.678
2019 Chariker JH, Ohri SS, Gomes C, Brabazon F, Harman KA, DeVeau KM, Magnuson DSK, Hetman M, Petruska JC, Whittemore SR, Rouchka EC. Activity/exercise-induced changes in the liver transcriptome after chronic spinal cord injury. Scientific Data. 6: 88. PMID 31197156 DOI: 10.1038/S41597-019-0087-5  0.428
2019 Chariker JH, Gomes C, Brabazon F, Harman KA, Ohri SS, Magnuson DSK, Whittemore SR, Petruska JC, Rouchka EC. Transcriptome of dorsal root ganglia caudal to a spinal cord injury with modulated behavioral activity. Scientific Data. 6: 83. PMID 31175296 DOI: 10.1038/S41597-019-0088-4  0.531
2018 Myers SA, Gobejishvili L, Saraswat Ohri S, Garrett Wilson C, Andres KR, Riegler AS, Donde H, Joshi-Barve S, Barve S, Whittemore SR. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Neurobiology of Disease. 124: 353-363. PMID 30557659 DOI: 10.1016/j.nbd.2018.12.008  0.405
2018 Ohri SS, Bankston AN, Mullins SA, Liu Y, Andres KR, Beare JE, Howard RM, Burke DA, Riegler AS, Smith AE, Hetman M, Whittemore SR. Blocking autophagy in oligodendrocytes limits functional recovery after spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29793971 DOI: 10.1523/JNEUROSCI.0679-17.2018  0.458
2017 Pocratsky AM, Burke DA, Morehouse JR, Beare JE, Riegler AS, Tsoulfas P, States GJR, Whittemore SR, Magnuson DSK. Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation. Nature Communications. 8: 1963. PMID 29213073 DOI: 10.1038/S41467-017-02033-X  0.353
2017 Kilanczyk E, Andres KR, Hallgren J, Ohri SS, Laiho M, Whittemore SR, Hetman M. Pharmacological inhibition of spinal cord injury-stimulated ribosomal biogenesis does not affect locomotor outcome. Neuroscience Letters. PMID 28188847 DOI: 10.1016/j.neulet.2017.02.011  0.491
2016 Myers SA, Bankston AN, Burke DA, Ohri SS, Whittemore SR. Does the preclinical evidence for functional remyelination following engraftment into the injured spinal cord support progression to clinical trials? Experimental Neurology. PMID 27085393 DOI: 10.1016/j.expneurol.2016.04.009  0.377
2016 Saraswat Ohri S, Hetman M, Whittemore SR. ATF6α deletion modulates the ER stress response after spinal cord injury but does not affect locomotor recovery. Journal of Neurotrauma. PMID 26842780 DOI: 10.1089/neu.2015.3993  0.417
2014 Ohri SS, Mullins A, Hetman M, Whittemore SR. Inhibition of GADD34, the stress-inducible regulatory subunit of the endoplasmic reticulum stress response, does not enhance functional recovery after spinal cord injury. Plos One. 9: e109703. PMID 25386686 DOI: 10.1371/journal.pone.0109703  0.393
2014 Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, ... ... Whittemore SR, et al. Development of a database for translational spinal cord injury research. Journal of Neurotrauma. 31: 1789-99. PMID 25077610 DOI: 10.1089/Neu.2014.3399  0.684
2014 Myers SA, Andres KR, Hagg T, Whittemore SR. CD36 deletion improves recovery from spinal cord injury. Experimental Neurology. 256: 25-38. PMID 24690303 DOI: 10.1016/j.expneurol.2014.03.016  0.325
2013 Ohri SS, Hetman M, Whittemore SR. Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury. Neurobiology of Disease. 58: 29-37. PMID 23659896 DOI: 10.1016/j.nbd.2013.04.021  0.479
2013 Kuypers NJ, James KT, Enzmann GU, Magnuson DS, Whittemore SR. Functional consequences of ethidium bromide demyelination of the mouse ventral spinal cord. Experimental Neurology. 247: 615-22. PMID 23466931 DOI: 10.1016/j.expneurol.2013.02.014  0.721
2013 Burke DA, Whittemore SR, Magnuson DS. Consequences of common data analysis inaccuracies in CNS trauma injury basic research. Journal of Neurotrauma. 30: 797-805. PMID 23186206 DOI: 10.1089/neu.2012.2704  0.651
2012 Cao Q, Whittemore SR. Cell transplantation: stem cells and precursor cells. Handbook of Clinical Neurology. 109: 551-61. PMID 23098736 DOI: 10.1016/B978-0-444-52137-8.00034-6  0.381
2012 Fassbender JM, Saraswat-Ohri S, Myers SA, Gruenthal MJ, Benton RL, Whittemore SR. Deletion of endoplasmic reticulum stress-induced CHOP protects microvasculature post-spinal cord injury. Current Neurovascular Research. 9: 274-81. PMID 22873727 DOI: 10.2174/156720212803530627  0.357
2012 Myers SA, DeVries WH, Gruenthal MJ, Andres KR, Hagg T, Whittemore SR. Sildenafil improves epicenter vascular perfusion but not hindlimb functional recovery after contusive spinal cord injury in mice. Journal of Neurotrauma. 29: 528-38. PMID 21970599 DOI: 10.1089/neu.2011.2036  0.506
2012 Ohri SS, Maddie MA, Zhang Y, Shields CB, Hetman M, Whittemore SR. Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury. Journal of Neurotrauma. 29: 579-88. PMID 21933012 DOI: 10.1089/neu.2011.1940  0.478
2011 Zhu Q, Whittemore SR, Devries WH, Zhao X, Kuypers NJ, Qiu M. Dorsally-derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination. Glia. 59: 1612-21. PMID 21710609 DOI: 10.1002/Glia.21203  0.516
2011 Yu P, Zhang YP, Shields LB, Zheng Y, Hu X, Hill R, Howard R, Gu Z, Burke DA, Whittemore SR, Xu XM, Shields CB. Inhibitor of DNA binding 2 promotes sensory axonal growth after SCI. Experimental Neurology. 231: 38-44. PMID 21679705 DOI: 10.1016/J.Expneurol.2011.05.013  0.411
2011 Ohri SS, Maddie MA, Zhao Y, Qiu MS, Hetman M, Whittemore SR. Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury. Glia. 59: 1489-502. PMID 21638341 DOI: 10.1002/glia.21191  0.514
2011 Wang Y, Cheng X, He Q, Zheng Y, Kim DH, Whittemore SR, Cao QL. Astrocytes from the contused spinal cord inhibit oligodendrocyte differentiation of adult oligodendrocyte precursor cells by increasing the expression of bone morphogenetic proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6053-8. PMID 21508230 DOI: 10.1523/JNEUROSCI.5524-09.2011  0.464
2011 Fassbender JM, Whittemore SR, Hagg T. Targeting microvasculature for neuroprotection after SCI. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 8: 240-51. PMID 21360237 DOI: 10.1007/s13311-011-0029-1  0.366
2011 Fassbender JM, Myers SA, Whittemore SR. Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery. Experimental Neurology. 227: 302-13. PMID 21156172 DOI: 10.1016/j.expneurol.2010.12.002  0.323
2010 Mozer AB, Whittemore SR, Benton RL. Spinal microvascular expression of PV-1 is associated with inflammation, perivascular astrocyte loss, and diminished EC glucose transport potential in acute SCI. Current Neurovascular Research. 7: 238-50. PMID 20590523 DOI: 10.2174/156720210792231840  0.413
2010 Han S, Arnold SA, Sithu SD, Mahoney ET, Geralds JT, Tran P, Benton RL, Maddie MA, D'Souza SE, Whittemore SR, Hagg T. Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury. Brain : a Journal of Neurology. 133: 1026-42. PMID 20375135 DOI: 10.1093/brain/awq034  0.425
2010 Cao Q, He Q, Wang Y, Cheng X, Howard RM, Zhang Y, DeVries WH, Shields CB, Magnuson DS, Xu XM, Kim DH, Whittemore SR. Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2989-3001. PMID 20181596 DOI: 10.1523/JNEUROSCI.3174-09.2010  0.74
2010 Kirschner DA, Avila RL, Gamez Sazo RE, Luoma A, Enzmann GU, Agrawal D, Inouye H, Bunge MB, Kocsis J, Peters A, Whittemore SR. Rapid assessment of internodal myelin integrity in central nervous system tissue. Journal of Neuroscience Research. 88: 712-21. PMID 19795370 DOI: 10.1002/Jnr.22241  0.423
2009 Beare JE, Morehouse JR, DeVries WH, Enzmann GU, Burke DA, Magnuson DS, Whittemore SR. Gait analysis in normal and spinal contused mice using the TreadScan system. Journal of Neurotrauma. 26: 2045-56. PMID 19886808 DOI: 10.1089/neu.2009.0914  0.73
2009 Benton RL, Maddie MA, Dincman TA, Hagg T, Whittemore SR. Transcriptional activation of endothelial cells by TGFβ coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury. Asn Neuro. 1. PMID 19663807 DOI: 10.1042/AN20090008  0.476
2009 Benton RL, Maddie MA, Gruenthal MJ, Hagg T, Whittemore SR. Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery. Current Neurovascular Research. 6: 124-31. PMID 19442162 DOI: 10.2174/156720209788185678  0.39
2009 Hill RL, Zhang YP, Burke DA, Devries WH, Zhang Y, Magnuson DS, Whittemore SR, Shields CB. Anatomical and functional outcomes following a precise, graded, dorsal laceration spinal cord injury in C57BL/6 mice. Journal of Neurotrauma. 26: 1-15. PMID 19196178 DOI: 10.1089/neu.2008.0543  0.743
2009 Mahoney ET, Benton RL, Maddie MA, Whittemore SR, Hagg T. ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice. The Journal of Comparative Neurology. 512: 243-55. PMID 19003792 DOI: 10.1002/cne.21902  0.464
2008 Zhang YP, Burke DA, Shields LB, Chekmenev SY, Dincman T, Zhang Y, Zheng Y, Smith RR, Benton RL, DeVries WH, Hu X, Magnuson DS, Whittemore SR, Shields CB. Spinal cord contusion based on precise vertebral stabilization and tissue displacement measured by combined assessment to discriminate small functional differences. Journal of Neurotrauma. 25: 1227-40. PMID 18986224 DOI: 10.1089/neu.2007.0388  0.722
2008 Benton RL, Maddie MA, Worth CA, Mahoney ET, Hagg T, Whittemore SR. Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1771-85. PMID 18612314 DOI: 10.1038/jcbfm.2008.76  0.473
2008 Whittemore SR, Zhang YP, Shields CB, Magnuson DS. Optimizing stem cell grafting into the CNS. Methods in Molecular Biology (Clifton, N.J.). 438: 375-82. PMID 18369772 DOI: 10.1007/978-1-59745-133-8_29  0.62
2008 Benton RL, Maddie MA, Minnillo DR, Hagg T, Whittemore SR. Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse. The Journal of Comparative Neurology. 507: 1031-52. PMID 18092342 DOI: 10.1002/cne.21570  0.48
2007 Cruz-Orengo L, Figueroa JD, Torrado A, Puig A, Whittemore SR, Miranda JD. Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response. Neuroscience Letters. 418: 49-54. PMID 17418490 DOI: 10.1016/J.Neulet.2007.03.015  0.412
2007 Talbott JF, Cao Q, Bertram J, Nkansah M, Benton RL, Lavik E, Whittemore SR. CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Experimental Neurology. 204: 485-9. PMID 17274982 DOI: 10.1016/J.Expneurol.2006.12.013  0.466
2006 Figueroa JD, Benton RL, Velazquez I, Torrado AI, Ortiz CM, Hernandez CM, Diaz JJ, Magnuson DS, Whittemore SR, Miranda JD. Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. Journal of Neuroscience Research. 84: 1438-51. PMID 16983667 DOI: 10.1002/Jnr.21048  0.718
2006 Cruz-Orengo L, Figueroa JD, Velázquez I, Torrado A, Ortíz C, Hernández C, Puig A, Segarra AC, Whittemore SR, Miranda JD. Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. Experimental Neurology. 202: 421-33. PMID 16959251 DOI: 10.1016/J.Expneurol.2006.07.005  0.475
2006 Talbott JF, Cao Q, Enzmann GU, Benton RL, Achim V, Cheng XX, Mills MD, Rao MS, Whittemore SR. Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent. Glia. 54: 147-59. PMID 16921543 DOI: 10.1002/glia.20369  0.425
2006 Abdellatif AA, Pelt JL, Benton RL, Howard RM, Tsoulfas P, Ping P, Xu XM, Whittemore SR. Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems. Journal of Neuroscience Research. 84: 553-67. PMID 16786574 DOI: 10.1002/Jnr.20968  0.343
2006 Enzmann GU, Benton RL, Talbott JF, Cao Q, Whittemore SR. Functional considerations of stem cell transplantation therapy for spinal cord repair. Journal of Neurotrauma. 23: 479-95. PMID 16629631 DOI: 10.1089/neu.2006.23.479  0.421
2005 Benton RL, Woock JP, Gozal E, Hetman M, Whittemore SR. Intraspinal application of endothelin results in focal ischemic injury of spinal gray matter and restricts the differentiation of engrafted neural stem cells. Neurochemical Research. 30: 809-23. PMID 16187216 DOI: 10.1007/s11064-005-6875-7  0.5
2005 Enzmann GU, Benton RL, Woock JP, Howard RM, Tsoulfas P, Whittemore SR. Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord. Experimental Neurology. 195: 293-304. PMID 16087174 DOI: 10.1016/J.Expneurol.2005.04.021  0.494
2005 Irizarry-Ramírez M, Willson CA, Cruz-Orengo L, Figueroa J, Velázquez I, Jones H, Foster RD, Whittemore SR, Miranda JD. Upregulation of EphA3 receptor after spinal cord injury. Journal of Neurotrauma. 22: 929-35. PMID 16083359 DOI: 10.1089/Neu.2005.22.929  0.505
2005 Cao Q, Xu XM, Devries WH, Enzmann GU, Ping P, Tsoulfas P, Wood PM, Bunge MB, Whittemore SR. Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6947-57. PMID 16049170 DOI: 10.1523/Jneurosci.1065-05.2005  0.534
2005 Talbott JF, Loy DN, Liu Y, Qiu MS, Bunge MB, Rao MS, Whittemore SR. Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes. Experimental Neurology. 192: 11-24. PMID 15698615 DOI: 10.1016/J.Expneurol.2004.05.038  0.472
2005 Loy DN, Sroufe AE, Pelt JL, Burke DA, Cao QL, Talbott JF, Whittemore SR. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100beta. Neurosurgery. 56: 391-7; discussion 39. PMID 15670387  0.427
2005 Cao Q, Zhang YP, Iannotti C, DeVries WH, Xu XM, Shields CB, Whittemore SR. Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat. Experimental Neurology. 191: S3-S16. PMID 15629760 DOI: 10.1016/j.expneurol.2004.08.026  0.559
2003 Benton RL, Whittemore SR. VEGF165 therapy exacerbates secondary damage following spinal cord injury. Neurochemical Research. 28: 1693-703. PMID 14584823 DOI: 10.1023/A:1026013106016  0.474
2003 Willson CA, Miranda JD, Foster RD, Onifer SM, Whittemore SR. Transection of the adult rat spinal cord upregulates EphB3 receptor and ligand expression. Cell Transplantation. 12: 279-90. PMID 12797382 DOI: 10.3727/000000003108746830  0.48
2002 Loy DN, Talbott JF, Onifer SM, Mills MD, Burke DA, Dennison JB, Fajardo LC, Magnuson DS, Whittemore SR. Both dorsal and ventral spinal cord pathways contribute to overground locomotion in the adult rat. Experimental Neurology. 177: 575-80. PMID 12429203 DOI: 10.1006/exnr.2002.7959  0.719
2002 Cao QL, Howard RM, Dennison JB, Whittemore SR. Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord. Experimental Neurology. 177: 349-59. PMID 12429182 DOI: 10.1006/exnr.2002.7981  0.442
2002 Willson CA, Irizarry-Ramírez M, Gaskins HE, Cruz-Orengo L, Figueroa JD, Whittemore SR, Miranda JD. Upregulation of EphA receptor expression in the injured adult rat spinal cord. Cell Transplantation. 11: 229-39. PMID 12075988 DOI: 10.3727/096020198389997  0.417
2002 Whittemore SR, Zhang YP, Shields CB, Morassutti DJ, Magnuson DS. Optimizing stem cell grafting into the CNS. Methods in Molecular Biology (Clifton, N.J.). 198: 319-25. PMID 11951635 DOI: 10.1385/1-59259-186-8:319  0.595
2002 Loy DN, Crawford CH, Darnall JB, Burke DA, Onifer SM, Whittemore SR. Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat. The Journal of Comparative Neurology. 445: 308-24. PMID 11920709 DOI: 10.1002/cne.10168  0.397
2002 Loy DN, Magnuson DS, Zhang YP, Onifer SM, Mills MD, Cao QL, Darnall JB, Fajardo LC, Burke DA, Whittemore SR. Functional redundancy of ventral spinal locomotor pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 315-23. PMID 11756515  0.719
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