Sarah C. Lummis - Related publications

Affiliations: 
Biochemistry University of Cambridge, Cambridge, England, United Kingdom 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Hughes ME, Mesoy SM, Capes E, Lummis SCR. Many Proline Residues in the Extracellular Domain Contribute to Glycine Receptor Function. Acs Chemical Neuroscience. PMID 32786326 DOI: 10.1021/acschemneuro.0c00320   
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of muscimol binding and gating by allosteric modulators of the GABA receptor: relating occupancy to state functions. Molecular Pharmacology. PMID 32723768 DOI: 10.1124/molpharm.120.000066   
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA Receptor: Relating Occupancy to State Functions. Molecular Pharmacology. 98: 303-313. PMID 32873746 DOI: 10.1124/molpharm.120.000066   
2020 Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature. PMID 32879488 DOI: 10.1038/s41586-020-2654-5   
2020 Germann AL, Reichert DE, Burbridge AB, Pierce SR, Evers AS, Steinbach JH, Akk G. Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites. Molecular Pharmacology. PMID 32675382 DOI: 10.1124/mol.120.119842   
2020 Ellaithy A, Gonzalez-Maeso J, Logothetis DA, Levitz J. Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in Biochemical Sciences. PMID 32861513 DOI: 10.1016/j.tibs.2020.07.008   
2020 Evenseth LSM, Ocello R, Gabrielsen M, Masetti M, Recanatini M, Sylte I, Cavalli A. Exploring Conformational Dynamics of the Extracellular Domain of the GABA Receptor: A Path-Metadynamics Study. Journal of Chemical Information and Modeling. 60: 2294-2303. PMID 32233432 DOI: 10.1021/acs.jcim.0c00163   
2020 Schlezinger JJ, Heiger-Bernays W, Webster TF. Predicting the activation of the androgen receptor by mixtures of ligands using Generalized Concentration Addition. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32726424 DOI: 10.1093/toxsci/kfaa108   
2020 Oliveira ASF, Ibarra AA, Bermudez I, Casalino L, Gaieb Z, Shoemark DK, Gallagher T, Sessions RB, Amaro RE, Mulholland AJ. Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors and suggest subtype specificity. Biorxiv : the Preprint Server For Biology. PMID 32743575 DOI: 10.1101/2020.07.16.206680   
2020 Ortega G, Mariottini D, Troina A, Dahlquist FW, Ricci F, Plaxco KW. Rational design to control the trade-off between receptor affinity and cooperativity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32727893 DOI: 10.1073/pnas.2006254117   
2020 Lillo A, Martínez-Pinilla E, Reyes-Resina I, Navarro G, Franco R. Adenosine A and A Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences. 21. PMID 32709103 DOI: 10.3390/ijms21145070   
2020 Greenfield DA, Schmidt HR, Skiba MA, Mandler MD, Anderson JR, Sliz P, Kruse AC. Virtual Screening for Ligand Discovery at the σ Receptor. Acs Medicinal Chemistry Letters. 11: 1555-1561. PMID 32832023 DOI: 10.1021/acsmedchemlett.9b00314   
2020 Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 30: 127501. PMID 32882418 DOI: 10.1016/j.bmcl.2020.127501   
2020 Gao L, Yang Z, Xiong J, Hao C, Ma R, Liu X, Liu BF, Jin J, Zhang G, Chen Y. Design, Synthesis and Biological Investigation of Flavone Derivatives as Potential Multi-Receptor Atypical Antipsychotics. Molecules (Basel, Switzerland). 25. PMID 32911828 DOI: 10.3390/molecules25184107   
2020 Gutjahr A, Papagno L, Vernejoul F, Lioux T, Jospin F, Chanut B, Perouzel E, Rochereau N, Appay V, Verrier B, Paul S. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses. Ebiomedicine. 58: 102922. PMID 32739871 DOI: 10.1016/j.ebiom.2020.102922   
2020 Gutjahr A, Papagno L, Vernejoul F, Lioux T, Jospin F, Chanut B, Perouzel E, Rochereau N, Appay V, Verrier B, Paul S. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses. Ebiomedicine. 58: 102922. PMID 32739871 DOI: 10.1016/j.ebiom.2020.102922   
2020 Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, et al. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature Communications. 11: 4121. PMID 32807782 DOI: 10.1038/s41467-020-17933-8   
2020 Wang S, Liu H, Lei K, Li G, Li J, Wei Y, Wang X, Liu R. Synthesis of 3,4-dihydroquinolin-2(1H)-one derivatives with anticonvulsant activity and their binding to the GABA receptor. Bioorganic Chemistry. 103: 104182. PMID 32890992 DOI: 10.1016/j.bioorg.2020.104182   
2020 Motawe ZY, Abdelmaboud SS, Cuevas J, Breslin JW. PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation. The International Journal of Biochemistry & Cell Biology. 126: 105803. PMID 32668330 DOI: 10.1016/j.biocel.2020.105803   
2020 Gelfuso EA, Reis SL, Aguiar DSR, Faggion SA, Gomes FMM, Galan DT, Peigneur S, Pereira AMS, Mortari MR, Cunha AOS, Tytgat J, Beleboni RO. New insights in the mode of action of (+)-erythravine and (+)-11α-hydroxy-erythravine alkaloids. European Journal of Pharmacology. 173390. PMID 32735983 DOI: 10.1016/j.ejphar.2020.173390   
2020 Morales P, Navarro G, Gómez-Autet M, Redondo L, Fernandez-Ruiz J, Perez-Benito L, Cordomi A, Pardo L, Franco R, Jagerovic N. Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32794211 DOI: 10.1002/chem.202003389   
2020 Kumar V, Hoag H, Sader S, Scorese N, Liu H, Wu C. GDP Release from the Open Conformation of Gα Requires Allosteric Signaling from the Agonist-Bound Human β Adrenergic Receptor. Journal of Chemical Information and Modeling. PMID 32786510 DOI: 10.1021/acs.jcim.0c00432   
2020 Daya R, Ho J, Thomson S, Bhandari J, Mishra RK. The Effect of PAOPA, a Novel Allosteric Modulator of Dopamine D2 Receptors, on Select Signaling Proteins Following Sub-Chronic Administration in the Rat. Current Molecular Pharmacology. PMID 32912130 DOI: 10.2174/1874467213666200910091007   
2020 Zheng M, Zhang X, Min X, Sun N, Kim KM. Cytoplasmic recruitment of Mdm2 as a common characteristic of G protein-coupled receptors that undergo desensitization. Biochemical and Biophysical Research Communications. 530: 181-188. PMID 32828283 DOI: 10.1016/j.bbrc.2020.06.091   
2020 Corrie LW, Stokes C, Wilkerson JL, Carroll FI, McMahon LR, Papke RL. Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives. Molecular Pharmacology. PMID 32690626 DOI: 10.1124/molpharm.120.000037   
2020 Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/s12248-020-00472-x   
2020 Kim T, Zhen J, Lee J, Bauer R, Lee C, Kwon BO, Chae KH, Hong S, Giesy JP, Chang GS, Khim JS. Influence of ligand's directional configuration, chrysenes as model compounds, on the binding activity with aryl hydrocarbon receptor. Scientific Reports. 10: 13821. PMID 32796895 DOI: 10.1038/s41598-020-70704-9   
2020 Rukavina Mikusic NL, Silva MG, Pineda AM, Gironacci MM. Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function? Frontiers in Pharmacology. 11: 1179. PMID 32848782 DOI: 10.3389/fphar.2020.01179   
2020 Cifani C, Micioni Di Bonaventura E, Botticelli L, Del Bello F, Giorgioni G, Pavletić P, Piergentili A, Quaglia W, Bonifazi A, Schepmann D, Wünsch B, Vistoli G, Micioni Di Bonaventura MV. Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Blocking the Binge Eating Episode in Female Rats. Acs Chemical Neuroscience. PMID 32886484 DOI: 10.1021/acschemneuro.0c00456   
2020 Silwal P, Paik S, Jeon SM, Jo EK. Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics. Cells. 9. PMID 32867365 DOI: 10.3390/cells9091979   
2020 Huang L, Gao L, Zhang X, Yin L, Hu J, Song T, Chen Y. Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics. Bioorganic & Medicinal Chemistry Letters. 127506. PMID 32828898 DOI: 10.1016/j.bmcl.2020.127506   
2020 Friedman S, Tauber M, Ben-Chaim Y. Sodium ions allosterically modulate the M2 muscarinic receptor. Scientific Reports. 10: 11177. PMID 32636499 DOI: 10.1038/s41598-020-68133-9   
2020 Li X, Shen L, Hua T, Liu ZJ. Structural and Functional Insights into Cannabinoid Receptors. Trends in Pharmacological Sciences. PMID 32739033 DOI: 10.1016/j.tips.2020.06.010   
2020 Kim M, Truss M, Pagare PP, Essandoh MA, Zhang Y, Williams DA. Structure Activity Relationship Exploration of 5-Hydroxy-2-(3-phenylpropyl)chromones as a Unique 5-HT Receptor Antagonist Scaffold. Bioorganic & Medicinal Chemistry Letters. 127511. PMID 32853682 DOI: 10.1016/j.bmcl.2020.127511   
2020 de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicology in Vitro : An International Journal Published in Association With Bibra. 104975. PMID 32858110 DOI: 10.1016/j.tiv.2020.104975   
2020 Watanabe M, Kobayashi T, Ito Y, Yamada S, Shuto S. Conformational Restriction of Histamine with a Rigid Bicyclo[3.1.0]hexane Scaffold Provided Selective H Receptor Ligands. Molecules (Basel, Switzerland). 25. PMID 32764432 DOI: 10.3390/molecules25163562   
2020 Ide H, Miyamoto H. The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis. Cancers. 12. PMID 32759680 DOI: 10.3390/cancers12082155   
2020 Palma JA, Gupta A, Sierra S, Gomes I, Balgobin B, Norcliffe-Kaufmann L, Devi LA, Kaufmann H. Autoantibodies blocking M muscarinic receptors cause postganglionic cholinergic dysautonomia. Annals of Neurology. PMID 32833276 DOI: 10.1002/ana.25882   
2020 Banerjee AA, Vaidya VA. Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT receptor. Biochemical and Biophysical Research Communications. PMID 32814630 DOI: 10.1016/j.bbrc.2020.08.022   
2020 Pismataro MC, Horenstein NA, Stokes C, Quadri M, De Amici M, Papke RL, Dallanoce C. Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation. European Journal of Medicinal Chemistry. 205: 112669. PMID 32810771 DOI: 10.1016/j.ejmech.2020.112669   
2020 Bozsoki Z, Gysel K, Hansen SB, Lironi D, Krönauer C, Feng F, de Jong N, Vinther M, Kamble M, Thygesen MB, Engholm E, Kofoed C, Fort S, Sullivan JT, Ronson CW, et al. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. Science (New York, N.Y.). 369: 663-670. PMID 32764065 DOI: 10.1126/science.abb3377   
2020 Bozsoki Z, Gysel K, Hansen SB, Lironi D, Krönauer C, Feng F, de Jong N, Vinther M, Kamble M, Thygesen MB, Engholm E, Kofoed C, Fort S, Sullivan JT, Ronson CW, et al. Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity. Science (New York, N.Y.). 369: 663-670. PMID 32764065 DOI: 10.1126/science.abb3377   
2020 Spillmann M, Thurner L, Romantini N, Zimmermann M, Meger B, Behe M, Waldhoer M, Schertler GFX, Berger P. New Insights into Arrestin Recruitment to GPCRs. International Journal of Molecular Sciences. 21. PMID 32668755 DOI: 10.3390/ijms21144949   
2020 Waltenspühl Y, Schöppe J, Ehrenmann J, Kummer L, Plückthun A. Crystal structure of the human oxytocin receptor. Science Advances. 6: eabb5419. PMID 32832646 DOI: 10.1126/sciadv.abb5419   
2020 Elisi GM, Bedini A, Scalvini L, Carmi C, Bartolucci S, Lucini V, Scaglione F, Mor M, Rivara S, Spadoni G. Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria. Molecules (Basel, Switzerland). 25. PMID 32899888 DOI: 10.3390/molecules25184057   
2020 Cui Y, Peng R, Song H, Tong Z, Qu X, Liu S, Zhao X, Chai Y, Wang P, Gao GF, Qi J. Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690697 DOI: 10.1073/pnas.2005341117   
2020 Cui Y, Peng R, Song H, Tong Z, Qu X, Liu S, Zhao X, Chai Y, Wang P, Gao GF, Qi J. Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690697 DOI: 10.1073/pnas.2005341117   
2020 Uribe-Herranz M, Kuguel SG, Casós K, Costa C. Characterization of putative regulatory isoforms of porcine tumor necrosis factor receptor 2 in endothelial cells. Xenotransplantation. e12635. PMID 32783288 DOI: 10.1111/xen.12635   
2020 Wang S, Liu H, Wang X, Lei K, Li G, Li J, Liu R, Quan Z. Synthesis of 1,3,4-oxadiazole derivatives with anticonvulsant activity and their binding to the GABA receptor. European Journal of Medicinal Chemistry. 206: 112672. PMID 32798790 DOI: 10.1016/j.ejmech.2020.112672   
2020 Chin AC, Yovanno RA, Wied TJ, Gershman A, Lau AY. D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2. Structure (London, England : 1993). PMID 32735769 DOI: 10.1016/j.str.2020.07.005