| Year |
Citation |
Score |
| 2023 |
Alrabghi G, Liu Y, Hu W, Hancox JC, Zhang H. Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 378: 20220166. PMID 37122220 DOI: 10.1098/rstb.2022.0166 |
0.319 |
|
| 2023 |
You T, Xie Y, Luo C, Zhang K, Zhang H. Mechanistic insights into spontaneous transition from cellular alternans to ventricular fibrillation. Physiological Reports. 11: e15619. PMID 36863774 DOI: 10.14814/phy2.15619 |
0.304 |
|
| 2022 |
Li Y, Wan R, Liu J, Liu W, Ma L, Zhang H. mechanisms of arsenic trioxide-induced cardiotoxicity. Frontiers in Physiology. 13: 1004605. PMID 36589437 DOI: 10.3389/fphys.2022.1004605 |
0.329 |
|
| 2022 |
Brocklehurst P, Zhang H, Ye J. Effects of fibroblast on electromechanical dynamics of human atrial tissue-insights from a 2D discrete element model. Frontiers in Physiology. 13: 938497. PMID 35957981 DOI: 10.3389/fphys.2022.938497 |
0.34 |
|
| 2021 |
Bai J, Zhu Y, Lo A, Gao M, Lu Y, Zhao J, Zhang H. In Silico Assessment of Class I Antiarrhythmic Drug Effects on -Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues. International Journal of Molecular Sciences. 22. PMID 33514068 DOI: 10.3390/ijms22031265 |
0.305 |
|
| 2020 |
Zhang H, Zhang S, Wang W, Wang K, Shen W. A Mathematical Model of the Mouse Atrial Myocyte With Inter-Atrial Electrophysiological Heterogeneity. Frontiers in Physiology. 11: 972. PMID 32848887 DOI: 10.3389/Fphys.2020.00972 |
0.426 |
|
| 2020 |
Zhao N, Li Q, Sui H, Zhang H. Role of Oxidation-Dependent CaMKII Activation in the Genesis of Abnormal Action Potentials in Atrial Cardiomyocytes: A Simulation Study. Biomed Research International. 2020: 1597012. PMID 32685443 DOI: 10.1155/2020/1597012 |
0.388 |
|
| 2020 |
Ni H, Iseppe AF, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. Populations of in silico myocytes and tissues reveal synergy of multi-atrial-predominant K -current block in atrial fibrillation. British Journal of Pharmacology. PMID 32667679 DOI: 10.1111/Bph.15198 |
0.377 |
|
| 2020 |
Zhao N, Li Q, Zhang K, Wang K, He R, Yuan Y, Zhang H. Heart failure-induced atrial remodelling promotes electrical and conduction alternans. Plos Computational Biology. 16: e1008048. PMID 32658888 DOI: 10.1371/Journal.Pcbi.1008048 |
0.402 |
|
| 2020 |
Li Y, Wang K, Li Q, Zhang H. Biological pacemaker: from biological experiments to computational simulation. Journal of Zhejiang University. Science. B. 21: 524-536. PMID 32633107 DOI: 10.1631/Jzus.B1900632 |
0.357 |
|
| 2020 |
Al-Moubarak E, Zhang Y, Dempsey CE, Zhang H, Harmer SC, Hancox JC. Serine mutation of a conserved threonine in the hERG K channel S6-pore region leads to loss-of-function through trafficking impairment. Biochemical and Biophysical Research Communications. PMID 32321643 DOI: 10.1016/J.Bbrc.2020.04.003 |
0.332 |
|
| 2020 |
Bai J, Lu Y, Lo A, Zhao J, Zhang H. PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating and -insights from human atrial modelling. Annals of Translational Medicine. 8: 191. PMID 32309338 DOI: 10.21037/Atm.2020.01.90 |
0.399 |
|
| 2020 |
Bai J, Lu Y, Zhang H. In silico study of the effects of anti-arrhythmic drug treatment on sinoatrial node function for patients with atrial fibrillation. Scientific Reports. 10: 305. PMID 31941982 DOI: 10.1038/S41598-019-57246-5 |
0.411 |
|
| 2019 |
Zhang S, Zhang S, Fan X, Wang W, Li Z, Jia D, Wei Z, Zhang H. Pro-arrhythmic Effects of Hydrogen Sulfide in Healthy and Ischemic Cardiac Tissues: Insight From a Simulation Study. Frontiers in Physiology. 10: 1482. PMID 31920692 DOI: 10.3389/Fphys.2019.01482 |
0.393 |
|
| 2019 |
Bai J, Lu Y, Lo A, Zhao J, Zhang H. Proarrhythmia in the p.Met207Val PITX2c-Linked Familial Atrial Fibrillation-Insights From Modeling. Frontiers in Physiology. 10: 1314. PMID 31695623 DOI: 10.3389/Fphys.2019.01314 |
0.429 |
|
| 2019 |
Liang C, Wang K, Li Q, Bai J, Zhang H. Influence of the distribution of fibrosis within an area of myocardial infarction on wave propagation in ventricular tissue. Scientific Reports. 9: 14151. PMID 31578428 DOI: 10.1038/S41598-019-50478-5 |
0.349 |
|
| 2019 |
Linscheid N, Logantha SJRJ, Poulsen PC, Zhang S, Schrölkamp M, Egerod KL, Thompson JJ, Kitmitto A, Galli G, Humphries MJ, Zhang H, Pers TH, Olsen JV, Boyett M, Lundby A. Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking. Nature Communications. 10: 2889. PMID 31253831 DOI: 10.1038/S41467-019-10709-9 |
0.356 |
|
| 2019 |
Orini M, Yanni J, Taggart P, Hanson B, Hayward M, Smith A, Zhang H, Colman M, Jones G, Jie X, Dobrzynski H, Boyett MR, Lambiase PD. Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. PMID 30753421 DOI: 10.1093/Europace/Euz007 |
0.387 |
|
| 2019 |
He R, Liu Y, Wang K, Zhao N, Yuan Y, Li Q, Zhang H. Automatic Cardiac Arrhythmia Classification Using Combination of Deep Residual Network and Bidirectional LSTM Ieee Access. 7: 102119-102135. DOI: 10.1109/Access.2019.2931500 |
0.318 |
|
| 2018 |
Whittaker DG, Hancox JC, Zhang H. Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome. Frontiers in Physiology. 9: 1888. PMID 30687112 DOI: 10.3389/Fphys.2018.01888 |
0.435 |
|
| 2018 |
Ni H, Zhang H, Grandi E, Narayan SM, Giles W. Transient Outward K Current Can Strongly Modulate Action Potential Duration and Initiate Alternans in Human Atrium. American Journal of Physiology. Heart and Circulatory Physiology. PMID 30576220 DOI: 10.1152/Ajpheart.00251.2018 |
0.406 |
|
| 2018 |
Wang W, Zhang S, Ni H, Garratt CJ, Boyett MR, Hancox JC, Zhang H. Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study. Plos Computational Biology. 14: e1006594. PMID 30500818 DOI: 10.1371/Journal.Pcbi.1006594 |
0.439 |
|
| 2018 |
Whittaker DG, Colman MA, Ni H, Hancox JC, Zhang H. Human Atrial Arrhythmogenesis and Sinus Bradycardia in -Linked Short QT Syndrome: Insights From Computational Modelling. Frontiers in Physiology. 9: 1402. PMID 30337886 DOI: 10.3389/Fphys.2018.01402 |
0.406 |
|
| 2018 |
Choudhury M, Black N, Alghmdi A, D'Souza A, Wang R, Yanni J, Dobrzynski H, Kingston PA, Zhang H, Boyett MR, Morris GM. TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome. The Journal of Physiology. PMID 30259525 DOI: 10.1113/Jp276508 |
0.357 |
|
| 2018 |
He R, Wang K, Zhao N, Liu Y, Yuan Y, Li Q, Zhang H. Automatic Detection of Atrial Fibrillation Based on Continuous Wavelet Transform and 2D Convolutional Neural Networks. Frontiers in Physiology. 9: 1206. PMID 30214416 DOI: 10.3389/Fphys.2018.01206 |
0.359 |
|
| 2018 |
Stephenson RS, Rowley-Nobel J, Jones CB, Guerrero R, Lowe T, Zhao J, Zhang H, Jarvis JC. Morphological Substrates for Atrial Arrhythmogenesis in a Heart With Atrioventricular Septal Defect. Frontiers in Physiology. 9: 1071. PMID 30190677 DOI: 10.3389/Fphys.2018.01071 |
0.413 |
|
| 2018 |
Testrow CP, Holden AV, Shmygol A, Zhang H. A computational model of excitation and contraction in uterine myocytes from the pregnant rat. Scientific Reports. 8: 9159. PMID 29904075 DOI: 10.1038/S41598-018-27069-X |
0.354 |
|
| 2018 |
Webb K, Logantha SJ, Absi M, Cartwright E, Zhang H, Monfredi O, Boyett MR. P5702Obesity causes cardiac ion channel remodelling and increases the propensity for atrial arrhythmias European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy566.P5702 |
0.363 |
|
| 2017 |
Xia Y, Wulan N, Wang K, Zhang H. Detecting atrial fibrillation by deep convolutional neural networks. Computers in Biology and Medicine. 93: 84-92. PMID 29291535 DOI: 10.1016/J.Compbiomed.2017.12.007 |
0.334 |
|
| 2017 |
Luo C, Wang K, Zhang H. Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome. Oncotarget. 8: 106511-106526. PMID 29290967 DOI: 10.18632/Oncotarget.22490 |
0.419 |
|
| 2017 |
Ni H, Whittaker DG, Wang W, Giles WR, Narayan SM, Zhang H. Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Frontiers in Physiology. 8: 946. PMID 29218016 DOI: 10.3389/Fphys.2017.00946 |
0.42 |
|
| 2017 |
Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. Frontiers in Physiology. 8: 759. PMID 29085299 DOI: 10.3389/Fphys.2017.00759 |
0.411 |
|
| 2017 |
Bai J, Wang K, Liu Y, Li Y, Liang C, Luo G, Dong S, Yuan Y, Zhang H. Computational Cardiac Modeling Reveals Mechanisms of Ventricular Arrhythmogenesis in Long QT Syndrome Type 8: CACNA1C R858H Mutation Linked to Ventricular Fibrillation. Frontiers in Physiology. 8: 771. PMID 29046645 DOI: 10.3389/Fphys.2017.00771 |
0.407 |
|
| 2017 |
Luo G, Dong S, Wang K, Zuo W, Cao S, Zhang H. Multi-views Fusion CNN for Left Ventricular Volumes Estimation on Cardiac MR Images. Ieee Transactions On Bio-Medical Engineering. PMID 29035205 DOI: 10.1109/Tbme.2017.2762762 |
0.32 |
|
| 2017 |
Bai X, Wang K, Yuan Y, Li Q, Dobrzynski H, Boyett MR, Hancox JC, Zhang H. Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study. Chaos (Woodbury, N.Y.). 27: 093934. PMID 28964153 DOI: 10.1063/1.5002664 |
0.452 |
|
| 2017 |
Ni H, Wang Y, Crawford W, Zhang S, Cheng L, Zhang H, Lei M. Three-dimensional image reconstruction of distribution of Pnmt(+) cell-derived cells in murine heart. Scientific Data. 4: 170134. PMID 28949324 DOI: 10.1038/Sdata.2017.134 |
0.307 |
|
| 2017 |
Adeniran I, Whittaker DG, El Harchi A, Hancox JC, Zhang H. In silico investigation of a KCNQ1 mutation associated with short QT syndrome. Scientific Reports. 7: 8469. PMID 28814790 DOI: 10.1038/S41598-017-08367-2 |
0.398 |
|
| 2017 |
Luo C, Wang K, Zhang H. Modelling the Effects of Quinidine, Disopyramide, and E-4031 on Short QT Syndrome Variant 3 in the Human Ventricles. Physiological Measurement. PMID 28812984 DOI: 10.1088/1361-6579/Aa8695 |
0.426 |
|
| 2017 |
Ashrafi R, Modi P, Oo AY, Pullan DM, Jian K, Zhang H, Gerges JY, Hart G, Boyett MR, Davis GK, Wilding JPH. Arrhythmogenic gene remodelling in elderly patients with type 2 diabetes with aortic stenosis and normal left ventricular ejection fraction. Experimental Physiology. PMID 28804970 DOI: 10.1113/Ep086412 |
0.331 |
|
| 2017 |
Ni H, Adeniran I, Zhang H. In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics. Journal of Molecular and Cellular Cardiology. PMID 28803858 DOI: 10.1016/J.Yjmcc.2017.08.005 |
0.361 |
|
| 2017 |
Stephenson RS, Atkinson A, Kottas P, Perde F, Jafarzadeh F, Bateman M, Iaizzo PA, Zhao J, Zhang H, Anderson RH, Jarvis JC, Dobrzynski H. High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling. Scientific Reports. 7: 7188. PMID 28775383 DOI: 10.1038/S41598-017-07694-8 |
0.391 |
|
| 2017 |
Ni H, Narsingani K, Zhang H, Giles WR. Can Principles of the Surface Potential be Combined with Knowledge of Natural Products to Reduce Atrial Rhythm Disturbances? Acta Physiologica (Oxford, England). PMID 28719150 DOI: 10.1111/Apha.12918 |
0.332 |
|
| 2017 |
Luo C, Wang K, Zhang H. In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles. Plos One. 12: e0179515. PMID 28632743 DOI: 10.1371/Journal.Pone.0179515 |
0.373 |
|
| 2017 |
Colman MA, Ni H, Liang B, Schmitt N, Zhang H. In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis. Plos Computational Biology. 13: e1005587. PMID 28622331 DOI: 10.1371/Journal.Pcbi.1005587 |
0.394 |
|
| 2017 |
Whittaker DG, Ni H, Harchi AE, Hancox JC, Zhang H. Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria. Plos Computational Biology. 13: e1005593. PMID 28609477 DOI: 10.1371/Journal.Pcbi.1005593 |
0.381 |
|
| 2017 |
Yang F, Zhang L, Lu W, Zhang Y, Zuo W, Wang K, Zhang H. A composite visualization method for electrophysiology-morphous merging of human heart. Biomedical Engineering Online. 16: 70. PMID 28595607 DOI: 10.1186/S12938-017-0368-1 |
0.365 |
|
| 2017 |
Luo C, Wang K, Zhang H. Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study. Biomedical Engineering Online. 16: 69. PMID 28592292 DOI: 10.1186/S12938-017-0369-0 |
0.41 |
|
| 2017 |
Brocklehurst P, Ni H, Zhang H, Ye J. Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue. Plos One. 12: e0176607. PMID 28510575 DOI: 10.1371/Journal.Pone.0176607 |
0.431 |
|
| 2017 |
Bai J, Yin R, Wang K, Zhang H. Mechanisms Underlying the Emergence of Post-acidosis Arrhythmia at the Tissue Level: A Theoretical Study. Frontiers in Physiology. 8: 195. PMID 28424631 DOI: 10.3389/Fphys.2017.00195 |
0.413 |
|
| 2017 |
Alday EA, Colman MA, Langley P, Zhang H. Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs: A computational study. Plos Computational Biology. 13: e1005270. PMID 28253254 DOI: 10.1371/Journal.Pcbi.1005270 |
0.365 |
|
| 2017 |
Wang Y, Lin WK, Crawford W, Ni H, Bolton EL, Khan H, Shanks J, Bub G, Wang X, Paterson DJ, Zhang H, Galione A, Ebert SN, Terrar DA, Lei M. Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt(+) Cells in Murine Heart. Scientific Reports. 7: 40687. PMID 28084430 DOI: 10.1038/Srep40687 |
0.379 |
|
| 2017 |
Webb K, Absi M, Logantha S, Zaborska K, Gurney A, Heagarty A, Cartwright E, Zhang H, Monfredi O, Boyett M. P3011Obesity increases the propensity for atrial arrhythmias European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx504.P3011 |
0.369 |
|
| 2017 |
Yu S, Zhang S, Wang K, Xia Y, Zhang H. An efficient and fast GPU-based algorithm for visualizing large volume of 4D data from virtual heart simulations Biomedical Signal Processing and Control. 35: 8-18. DOI: 10.1016/J.Bspc.2017.01.015 |
0.301 |
|
| 2016 |
Yang F, Zhang L, Lu W, Liu L, Zhang Y, Zuo W, Wang K, Zhang H. Depth Attenuation Degree Based Visualization for Cardiac Ischemic Electrophysiological Feature Exploration. Biomed Research International. 2016: 2979081. PMID 28004002 DOI: 10.1155/2016/2979081 |
0.387 |
|
| 2016 |
Temple IP, Logantha SJ, Absi M, Zhang Y, Pervolaraki E, Yanni J, Atkinson A, Petkova M, Quigley GM, Castro S, Drinkhill M, Schneider H, Monfredi O, Cartwright E, Zi M, ... ... Zhang H, et al. Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension. Circulation. Arrhythmia and Electrophysiology. 9. PMID 27979911 DOI: 10.1161/Circep.115.003432 |
0.307 |
|
| 2016 |
Chowdhury SK, Liu W, Zi M, Li Y, Wang S, Tsui H, Prehar S, Castro SJ, Zhang H, Ji Y, Zhang X, Xiao RP, Zhang R, Lei M, Cyganek L, et al. Stress-Activated Kinase MKK7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention. Circulation. PMID 27899394 DOI: 10.1161/Circulationaha.116.022941 |
0.337 |
|
| 2016 |
Ashrafi R, Yon M, Pickavance L, Yanni Gerges J, Davis G, Wilding J, Jian K, Zhang H, Hart G, Boyett M. Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis. Journal of Obesity. 2016: 7127898. PMID 27747100 DOI: 10.1155/2016/7127898 |
0.306 |
|
| 2016 |
Alday EA, Ni H, Zhang C, Colman MA, Gan Z, Zhang H. Comparison of Electric- and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso. Plos One. 11: e0160999. PMID 27556808 DOI: 10.1371/Journal.Pone.0160999 |
0.371 |
|
| 2016 |
Bai J, Wang K, Li Q, Yuan Y, Zhang H. Pro-arrhythmogenic effects of CACNA1C G1911R mutation in human ventricular tachycardia: insights from cardiac multi-scale models. Scientific Reports. 6: 31262. PMID 27502440 DOI: 10.1038/Srep31262 |
0.401 |
|
| 2016 |
Kazmi SZ, Zhang H, Aziz W, Monfredi O, Abbas SA, Shah SA, Kazmi SS, Butt WH. Inverse Correlation between Heart Rate Variability and Heart Rate Demonstrated by Linear and Nonlinear Analysis. Plos One. 11: e0157557. PMID 27336907 DOI: 10.1371/Journal.Pone.0157557 |
0.342 |
|
| 2016 |
Cheng H, Li J, James AF, Inada S, Choisy SC, Orchard CH, Zhang H, Boyett MR, Hancox JC. Characterization and influence of cardiac background sodium current in the atrioventricular node. Journal of Molecular and Cellular Cardiology. PMID 27132017 DOI: 10.1016/J.Yjmcc.2016.04.014 |
0.338 |
|
| 2016 |
Zhang Y, Wang K, Li Q, Zhang H. Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K(+) Current: A Simulation Study. Biomed Research International. 2016: 3830682. PMID 26998484 DOI: 10.1155/2016/3830682 |
0.354 |
|
| 2016 |
Jiang L, Wang Y, Pan F, Zhao X, Zhang H, Lei M, Liu T, Lu JR. Synergistic effect of bioactive lipid and condition medium on cardiac differentiation of human mesenchymal stem cells from different tissues. Cell Biochemistry and Function. PMID 26990081 DOI: 10.1002/Cbf.3175 |
0.346 |
|
| 2016 |
Hancox JC, James AF, Marrion NV, Zhang H, Thomas D. Novel ion channel targets in atrial fibrillation. Expert Opinion On Therapeutic Targets. PMID 26918581 DOI: 10.1517/14728222.2016.1159300 |
0.381 |
|
| 2015 |
Wang Q, Kharche S, Jones G, Luo C, Tang C, Zhang H. Calcium leak induced arrhythmias in mouse sino-atrial node and ventricle cells: A simulation study. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2015: 4487-4490. PMID 26737291 DOI: 10.1109/EMBC.2015.7319391 |
0.559 |
|
| 2015 |
Adeniran I, MacIver DH, Garratt CJ, Ye J, Hancox JC, Zhang H. Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria. Plos One. 10: e0142397. PMID 26606047 DOI: 10.1371/Journal.Pone.0142397 |
0.41 |
|
| 2015 |
Kharche SR, Biktasheva IV, Seemann G, Zhang H, Biktashev VN. A Computer Simulation Study of Anatomy Induced Drift of Spiral Waves in the Human Atrium. Biomed Research International. 2015: 731386. PMID 26587545 DOI: 10.1155/2015/731386 |
0.599 |
|
| 2015 |
Brocklehurst P, Adeniran I, Yang D, Sheng Y, Zhang H, Ye J. A 2D Electromechanical Model of Human Atrial Tissue Using the Discrete Element Method. Biomed Research International. 2015: 854953. PMID 26583141 DOI: 10.1155/2015/854953 |
0.419 |
|
| 2015 |
Xia Y, Wang K, Zhang H. Parallel Optimization of 3D Cardiac Electrophysiological Model Using GPU. Computational and Mathematical Methods in Medicine. 2015: 862735. PMID 26581957 DOI: 10.1155/2015/862735 |
0.354 |
|
| 2015 |
Hancox JC, Adeniran I, Whittaker DG, Zhang H. Altered In Vivo Systolic Function In the Short Qt Syndrome Anticipated In Silico. Heart Rhythm : the Official Journal of the Heart Rhythm Society. PMID 26142296 DOI: 10.1016/J.Hrthm.2015.06.035 |
0.378 |
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| 2015 |
Adeniran I, MacIver DH, Hancox JC, Zhang H. Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study. Frontiers in Physiology. 6: 78. PMID 25852567 DOI: 10.3389/Fphys.2015.00078 |
0.367 |
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| 2015 |
Dibb K, Trafford A, Zhang H, Eisner D. A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 25750236 DOI: 10.1098/Rstb.2014.0316 |
0.393 |
|
| 2015 |
Alday EA, Colman MA, Langley P, Butters TD, Higham J, Workman AJ, Hancox JC, Zhang H. A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso. Plos Computational Biology. 11: e1004026. PMID 25611350 DOI: 10.1371/Journal.Pcbi.1004026 |
0.416 |
|
| 2015 |
Lu W, Li J, Yang F, Luo C, Wang K, Adeniran I, Zhang H. Effects Of Acute Global Ischemia On Re-Entrant Arrhythmogenesis: A Simulation Study Journal of Biological Systems. 23: 213-230. DOI: 10.1142/S0218339015500114 |
0.405 |
|
| 2014 |
Li J, Inada S, Schneider JE, Zhang H, Dobrzynski H, Boyett MR. Three-dimensional computer model of the right atrium including the sinoatrial and atrioventricular nodes predicts classical nodal behaviours. Plos One. 9: e112547. PMID 25380074 DOI: 10.1371/Journal.Pone.0112547 |
0.379 |
|
| 2014 |
Yuan Y, Bai X, Luo C, Wang K, Zhang H. The virtual heart as a platform for screening drug cardiotoxicity. British Journal of Pharmacology. PMID 25363597 DOI: 10.1111/Bph.12996 |
0.33 |
|
| 2014 |
Monfredi O, Lyashkov AE, Johnsen AB, Inada S, Schneider H, Wang R, Nirmalan M, Wisloff U, Maltsev VA, Lakatta EG, Zhang H, Boyett MR. Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate. Hypertension. 64: 1334-43. PMID 25225208 DOI: 10.1161/Hypertensionaha.114.03782 |
0.357 |
|
| 2014 |
Wang Y, Tsui H, Ke Y, Shi Y, Li Y, Davies L, Cartwright EJ, Venetucci L, Zhang H, Terrar DA, Huang CL, Solaro RJ, Wang X, Lei M. Pak1 is required to maintain ventricular Ca²⺠homeostasis and electrophysiological stability through SERCA2a regulation in mice. Circulation. Arrhythmia and Electrophysiology. 7: 938-48. PMID 25217043 DOI: 10.1161/Circep.113.001198 |
0.312 |
|
| 2014 |
Butters TD, Castro SJ, Lowe T, Zhang Y, Lei M, Withers PJ, Zhang H. Optimal iodine staining of cardiac tissue for X-ray computed tomography. Plos One. 9: e105552. PMID 25170844 DOI: 10.1371/Journal.Pone.0105552 |
0.33 |
|
| 2014 |
Zhang Y, Wang K, Yuan Y, Sui D, Zhang H. Effects of maximal sodium and potassium conductance on the stability of Hodgkin-Huxley model. Computational and Mathematical Methods in Medicine. 2014: 761907. PMID 25104970 DOI: 10.1155/2014/761907 |
0.315 |
|
| 2014 |
Kharche SR, Stary T, Colman MA, Biktasheva IV, Workman AJ, Rankin AC, Holden AV, Zhang H. Effects of human atrial ionic remodelling by β-blocker therapy on mechanisms of atrial fibrillation: a computer simulation Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 16: 1524-1533. PMID 25085203 DOI: 10.1016/J.Jelectrocard.2013.05.026 |
0.599 |
|
| 2014 |
Inada S, Zhang H, Tellez JO, Shibata N, Nakazawa K, Kamiya K, Kodama I, Mitsui K, Dobrzynski H, Boyett MR, Honjo H. Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing. Plos One. 9: e94565. PMID 24759974 DOI: 10.1371/Journal.Pone.0094565 |
0.345 |
|
| 2014 |
Davies L, Jin J, Shen W, Tsui H, Shi Y, Wang Y, Zhang Y, Hao G, Wu J, Chen S, Fraser JA, Dong N, Christoffels V, Ravens U, Huang CL, ... Zhang H, et al. Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age. Journal of the American Heart Association. 3: e000340. PMID 24721794 DOI: 10.1161/Jaha.113.000340 |
0.336 |
|
| 2014 |
Colman MA, Varela M, Hancox JC, Zhang H, Aslanidi OV. Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model Europace. 16: 416-423. PMID 24569896 DOI: 10.1093/Europace/Eut349 |
0.418 |
|
| 2014 |
Hancox JC, Kharche S, El Harchi A, Stott J, Law P, Zhang H. In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation. Journal of Electrocardiology. 47: 158-65. PMID 24411289 DOI: 10.1016/J.Jelectrocard.2013.12.004 |
0.597 |
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| 2014 |
Li J, Inada S, Schneider JE, Zhang H, Dobrzynski H, Boyett MR. Measurements of conduction velocity, maximum upstroke velocity of the action potential, action potential duration and refractory period of the SAN, atrial muscle and AVN from the Fitzhugh-Nagumo model and experiment. Plos One. DOI: 10.1371/Journal.Pone.0112547.T002 |
0.305 |
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| 2014 |
Colman MA, Castro SJ, Perez Alday EA, Hancox JC, Garratt C, Zhang H. Recent progress in multi-scale models of the human atria Drug Discovery Today: Disease Models. DOI: 10.1016/J.Ddmod.2014.04.003 |
0.422 |
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| 2014 |
Kharche S, Castro S, Thomas B, Colman M, Jarvis J, Smaill B, Zhang H, Stephenson R, Zhao J. Role of fiber orientation in atrial arrythmogenesis Computing in Cardiology. 41: 1041-1044. |
0.494 |
|
| 2014 |
Kharche S, Vigmond E, Ni H, Coleman M, Zhang H. Ischemia alters sensitivity of action potential to the sodium-potassium pump Computing in Cardiology. 41: 873-876. |
0.508 |
|
| 2014 |
Colman MA, Kharche S, Zhang H. Loss of transverse-tubules promotes the development of ectopic activity in guinea-pig ventricle Computing in Cardiology. 41: 1129-1132. |
0.497 |
|
| 2013 |
Aslanidi OV, Colman MA, Varela M, Zhao J, Smaill BH, Hancox JC, Boyett MR, Zhang H. Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation. Interface Focus. 3: 20120069. PMID 24427522 DOI: 10.1098/Rsfs.2012.0069 |
0.411 |
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| 2013 |
Butters TD, Aslanidi OV, Zhao J, Smaill B, Zhang H. A novel computational sheep atria model for the study of atrial fibrillation. Interface Focus. 3: 20120067. PMID 24427521 DOI: 10.1098/Rsfs.2012.0067 |
0.422 |
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| 2013 |
Pervolaraki E, Anderson RA, Benson AP, Hayes-Gill B, Holden AV, Moore BJ, Paley MN, Zhang H. Antenatal architecture and activity of the human heart. Interface Focus. 3: 20120065. PMID 24427520 DOI: 10.1098/Rsfs.2012.0065 |
0.419 |
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| 2013 |
Du C, El Harchi A, Zhang H, Hancox JC. Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition. Physiological Reports. 1: e00175. PMID 24400172 DOI: 10.1002/Phy2.175 |
0.342 |
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| 2013 |
Fenske S, Krause SC, Hassan SI, Becirovic E, Auer F, Bernard R, Kupatt C, Lange P, Ziegler T, Wotjak CT, Zhang H, Hammelmann V, Paparizos C, Biel M, Wahl-Schott CA. Sick sinus syndrome in HCN1-deficient mice. Circulation. 128: 2585-94. PMID 24218458 DOI: 10.1161/Circulationaha.113.003712 |
0.331 |
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| 2013 |
Kharche S, Beling J, Biktasheva IV, Zhang H, Biktashev VN. Simulating cell apoptosis induced sinus node dysfunction. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2013: 6842-5. PMID 24111316 DOI: 10.1109/EMBC.2013.6611129 |
0.594 |
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| 2013 |
Kharche SR, Biktasheva IV, Zhang H, Biktashev VN. Simulating the role of anisotropy in human atrial cardioversion. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2013: 6838-41. PMID 24111315 DOI: 10.1109/EMBC.2013.6611128 |
0.57 |
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| 2013 |
Zhang J, Li X, Liang L, Huang S, Zhang H. Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models. Science China. Life Sciences. 56: 818-22. PMID 23929003 DOI: 10.1007/S11427-013-4533-X |
0.354 |
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| 2013 |
Adeniran I, Hancox JC, Zhang H. In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling. Frontiers in Physiology. 4: 166. PMID 23847545 DOI: 10.3389/Fphys.2013.00166 |
0.442 |
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| 2013 |
Colman MA, Aslanidi OV, Kharche S, Boyett MR, Garratt C, Hancox JC, Zhang H. Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: Insights from the three-dimensional virtual human atria Journal of Physiology. 591: 4249-4272. PMID 23732649 DOI: 10.1113/Jphysiol.2013.254987 |
0.662 |
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| 2013 |
Boyett MR, D'Souza A, Zhang H, Morris GM, Dobrzynski H, Monfredi O. Viewpoint: is the resting bradycardia in athletes the result of remodeling of the sinoatrial node rather than high vagal tone? Journal of Applied Physiology (Bethesda, Md. : 1985). 114: 1351-5. PMID 23288551 DOI: 10.1152/Japplphysiol.01126.2012 |
0.305 |
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| 2013 |
Zang Y, Dai L, Zhan H, Dou J, Xia L, Zhang H. Theoretical investigation of the mechanism of heart failure using a canine ventricular cell model: especially the role of up-regulated CaMKII and SR Ca(2+) leak. Journal of Molecular and Cellular Cardiology. 56: 34-43. PMID 23220154 DOI: 10.1016/J.Yjmcc.2012.11.020 |
0.357 |
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| 2013 |
Zhao J, Butters TD, Zhang H, LeGrice IJ, Sands GB, Smaill BH. Image-based model of atrial anatomy and electrical activation: a computational platform for investigating atrial arrhythmia. Ieee Transactions On Medical Imaging. 32: 18-27. PMID 23192521 DOI: 10.1109/Tmi.2012.2227776 |
0.401 |
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| 2013 |
Di Veroli GY, Davies MR, Zhang H, Abi-Gerges N, Boyett MR. High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment American Journal of Physiology - Heart and Circulatory Physiology. 304: H104-H117. PMID 23103500 DOI: 10.1152/Ajpheart.00511.2012 |
0.306 |
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| 2013 |
Aslanidi OV, Nikolaidou T, Zhao J, Smaill BH, Gilbert SH, Holden AV, Lowe T, Withers PJ, Stephenson RS, Jarvis JC, Hancox JC, Boyett MR, Zhang H. Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development. Ieee Transactions On Medical Imaging. 32: 8-17. PMID 22829390 DOI: 10.1109/Tmi.2012.2209183 |
0.31 |
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| 2013 |
Adeniran I, Hancox JC, Zhang H. Effect of cardiac ventricular mechanical contraction on the characteristics of the ECG: A simulation study Journal of Biomedical Science and Engineering. 6: 47-60. DOI: 10.4236/Jbise.2013.612A007 |
0.442 |
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| 2013 |
Kharche S, Beling J, Biktasheva IV, Zhang H, Biktashev VN. Simulating cell apoptosis induced sinus node dysfunction Proceedings of the Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embs. 6842-6845. DOI: 10.1109/EMBC.2013.6611129 |
0.509 |
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| 2013 |
Kharche SR, Biktasheva IV, Zhang H, Biktashev VN. Simulating the role of anisotropy in human atrial cardioversion Proceedings of the Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embs. 6838-6841. DOI: 10.1109/EMBC.2013.6611128 |
0.549 |
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| 2013 |
Colman M, Aslanidi O, Kharche S, Boyett M, Zhang H. The effect of AF-induced electrical remodelling on regional electrical heterogeneity and tissue vulnerability to atrial fibrillation—insights from modelling Journal of Electrocardiology. 46: e18. DOI: 10.1016/J.Jelectrocard.2013.05.065 |
0.355 |
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| 2013 |
Alday EAP, Colman MA, Langley P, Holden AV, Zhang H. Multi-scale integrative model of the human atria and torso: a platform for the investigation of atrial arrhythmias Journal of Electrocardiology. 46. DOI: 10.1016/J.Jelectrocard.2013.05.064 |
0.339 |
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| 2013 |
Varela M, Colman MA, Zhang H, Aslanidi O. Realistic heterogeneous and anisotropic canine atrial model for the study of atrial arrhythmias Journal of Electrocardiology. 46. DOI: 10.1016/J.Jelectrocard.2013.05.040 |
0.4 |
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| 2013 |
Kharche SR, Stary T, Biktasheva IV, Zhang H, Biktashev VN. Computer simulation of the role of fibre orientation in cardioversion of chronic atrial fibrillation Journal of Electrocardiology. 46. DOI: 10.1016/J.Jelectrocard.2013.05.027 |
0.312 |
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| 2013 |
Castro SJ, Colman MA, Kharche S, Wang R, Zhang H. HCN and SCN5A channel mutations: Implications for impaired atrioventricular nodal conduction in a heterogeneous computer model of the whole mouse heart Computing in Cardiology. 40: 41-44. |
0.567 |
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| 2012 |
El Harchi A, Melgari D, Zhang YH, Zhang H, Hancox JC. Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K+ Channel Plos One. 7. PMID 23300672 DOI: 10.1371/Journal.Pone.0052451 |
0.352 |
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| 2012 |
Gaunt TR, Shah S, Nelson CP, Drenos F, Braund PS, Adeniran I, Folkersen L, Lawlor DA, Casas JP, Amuzu A, Kivimaki M, Whittaker J, Eriksson P, Zhang H, Hancox JC, et al. Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip. Circulation. Cardiovascular Genetics. 5: 630-8. PMID 23139254 DOI: 10.1161/Circgenetics.112.962852 |
0.324 |
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| 2012 |
Zhang H, Butters T, Adeniran I, Higham J, Holden AV, Boyett MR, Hancox JC. Modeling the chronotropic effect of isoprenaline on rabbit sinoatrial node. Frontiers in Physiology. 3: 241. PMID 23060799 DOI: 10.3389/Fphys.2012.00241 |
0.331 |
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| 2012 |
Hanson B, Gill J, Western D, Gilbey MP, Bostock J, Boyett MR, Zhang H, Coronel R, Taggart P. Cyclical modulation of human ventricular repolarization by respiration. Frontiers in Physiology. 3: 379. PMID 23055983 DOI: 10.3389/Fphys.2012.00379 |
0.328 |
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| 2012 |
Deng DD, Gong YL, Shou GF, Jiao PF, Zhang HG, Ye XS, Xia L. Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model. Journal of Zhejiang University. Science. B. 13: 676-94. PMID 22949359 DOI: 10.1631/Jzus.B1100339 |
0.348 |
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| 2012 |
Kharche S, Adeniran I, Stott J, Law P, Boyett MR, Hancox JC, Zhang H. Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling. The Journal of Physiology. 590: 4501-14. PMID 22508963 DOI: 10.1113/Jphysiol.2012.229146 |
0.646 |
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| 2012 |
Zhao J, Butters TD, Zhang H, Pullan AJ, LeGrice IJ, Sands GB, Smaill BH. An image-based model of atrial muscular architecture: effects of structural anisotropy on electrical activation. Circulation. Arrhythmia and Electrophysiology. 5: 361-70. PMID 22423141 DOI: 10.1161/Circep.111.967950 |
0.34 |
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| 2012 |
Nikolaidou T, Aslanidi OV, Zhang H, Efimov IR. Structure-function relationship in the sinus and atrioventricular nodes Pediatric Cardiology. 33: 890-899. PMID 22391764 DOI: 10.1007/S00246-012-0249-0 |
0.341 |
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| 2012 |
Adeniran I, El Harchi A, Hancox JC, Zhang H. Proarrhythmia in KCNJ2-linked short QT syndrome: Insights from modelling Cardiovascular Research. 94: 66-76. PMID 22308236 DOI: 10.1093/Cvr/Cvs082 |
0.388 |
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| 2012 |
Wu J, Zhang Y, Zhang X, Cheng L, Lammers WJ, Grace AA, Fraser JA, Zhang H, Huang CL, Lei M. Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1510-23. PMID 22287583 DOI: 10.1152/Ajpheart.00357.2011 |
0.405 |
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| 2012 |
Aslanidi OV, Al-Owais M, Benson AP, Colman M, Garratt CJ, Gilbert SH, Greenwood JP, Holden AV, Kharche S, Kinnell E, Pervolaraki E, Plein S, Stott J, Zhang H. Virtual tissue engineering of the human atrium: modelling pharmacological actions on atrial arrhythmogenesis. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 46: 209-21. PMID 21888968 DOI: 10.1016/J.Ejps.2011.08.014 |
0.664 |
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| 2012 |
Di Veroli GY, Davies M, Pollard CE, Valentin J, Zhang H, Boyett M, Gerges NA. Dynamics of drug binding to the hERG channel: An in silico cardiac action potential model for early safety assessment Journal of Pharmacological and Toxicological Methods. 66: 171. DOI: 10.1016/J.Vascn.2012.08.043 |
0.317 |
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| 2012 |
Kharche S, Biktasheva I, Seemann G, Zhang HG, Biktashev V. Cardioversion using feedback stimuli in human atria Computing in Cardiology. 39: 133-136. |
0.485 |
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| 2011 |
Aslanidi OV, Butters TD, Ren CX, Ryecroft G, Zhang H. Electrophysiological models for the heterogeneous canine atria: computational platform for studying rapid atrial arrhythmias. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 1693-6. PMID 22254651 DOI: 10.1109/IEMBS.2011.6090486 |
0.306 |
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| 2011 |
Adeniran I, McPate MJ, Witchel HJ, Hancox JC, Zhang H. Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome Plos Computational Biology. 7. PMID 22194679 DOI: 10.1371/Journal.Pcbi.1002313 |
0.419 |
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| 2011 |
Aslanidi O, Atia J, Benson AP, van den Berg HA, Blanks AM, Choi C, Gilbert SH, Goryanin I, Hayes-Gill BR, Holden AV, Li P, Norman JE, Shmygol A, Simpson NA, Taggart MJ, ... ... Zhang H, et al. Towards a computational reconstruction of the electrodynamics of premature and full term human labour. Progress in Biophysics and Molecular Biology. 107: 183-92. PMID 21777604 DOI: 10.1016/J.Pbiomolbio.2011.07.004 |
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| 2011 |
Aslanidi OV, Colman MA, Stott J, Dobrzynski H, Boyett MR, Holden AV, Zhang H. 3D virtual human atria: A computational platform for studying clinical atrial fibrillation. Progress in Biophysics and Molecular Biology. 107: 156-68. PMID 21762716 DOI: 10.1016/J.Pbiomolbio.2011.06.011 |
0.456 |
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| 2011 |
Colman MA, Aslanidi OV, Stott J, Holden AV, Zhang H. Correlation between P-wave morphology and origin of atrial focal tachycardia--insights from realistic models of the human atria and torso. Ieee Transactions On Bio-Medical Engineering. 58: 2952-5. PMID 21742568 DOI: 10.1109/Tbme.2011.2161305 |
0.38 |
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| 2011 |
Atkinson A, Inada S, Li J, Tellez JO, Yanni J, Sleiman R, Allah EA, Anderson RH, Zhang H, Boyett MR, Dobrzynski H. Anatomical and molecular mapping of the left and right ventricular His-Purkinje conduction networks Journal of Molecular and Cellular Cardiology. 51: 689-701. PMID 21741388 DOI: 10.1016/J.Yjmcc.2011.05.020 |
0.345 |
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| 2011 |
Kharche S, Yu J, Lei M, Zhang H. A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases American Journal of Physiology - Heart and Circulatory Physiology. 301: H945-H963. PMID 21724866 DOI: 10.1152/Ajpheart.00143.2010 |
0.64 |
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| 2011 |
Tong WC, Choi CY, Kharche S, Karche S, Holden AV, Zhang H, Taggart MJ. A computational model of the ionic currents, Ca2+ dynamics and action potentials underlying contraction of isolated uterine smooth muscle. Plos One. 6: e18685. PMID 21559514 DOI: 10.1371/Journal.Pone.0018685 |
0.596 |
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| 2011 |
Chandler N, Aslanidi O, Buckley D, Inada S, Birchall S, Atkinson A, Kirk D, Monfredi O, Molenaar P, Anderson R, Sharma V, Sigg D, Zhang H, Boyett M, Dobrzynski H. Computer three-dimensional anatomical reconstruction of the human sinus node and a novel paranodal area. Anatomical Record (Hoboken, N.J. : 2007). 294: 970-9. PMID 21538926 DOI: 10.1002/Ar.21379 |
0.36 |
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| 2011 |
Hao X, Zhang Y, Zhang X, Nirmalan M, Davies L, Konstantinou D, Yin F, Dobrzynski H, Wang X, Grace A, Zhang H, Boyett M, Huang CLH, Lei M. TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging Circulation: Arrhythmia and Electrophysiology. 4: 397-406. PMID 21493874 DOI: 10.1161/Circep.110.960807 |
0.352 |
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| 2011 |
Zi M, Kimura TE, Liu W, Jin J, Higham J, Kharche S, Hao G, Shi Y, Shen W, Prehar S, Mironov A, Neyses L, Bierhuizen MF, Boyett MR, Zhang H, et al. Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis. The Journal of Biological Chemistry. 286: 17821-30. PMID 21454599 DOI: 10.1074/Jbc.M111.228791 |
0.59 |
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| 2011 |
Clayton RH, Bernus O, Cherry EM, Dierckx H, Fenton FH, Mirabella L, Panfilov AV, Sachse FB, Seemann G, Zhang H. Models of cardiac tissue electrophysiology: progress, challenges and open questions. Progress in Biophysics and Molecular Biology. 104: 22-48. PMID 20553746 DOI: 10.1016/J.Pbiomolbio.2010.05.008 |
0.381 |
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| 2011 |
Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, Seemann G, Thul R, Zhang H, Sachse FB, Beard D, Crampin EJ, Smith NP. Cardiac cell modelling: observations from the heart of the cardiac physiome project. Progress in Biophysics and Molecular Biology. 104: 2-21. PMID 20303361 DOI: 10.1016/J.Pbiomolbio.2010.03.002 |
0.382 |
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| 2010 |
Aslanidi OV, Sleiman RN, Boyett MR, Hancox JC, Zhang H. Ionic mechanisms for electrical heterogeneity between rabbit purkinje fiber and ventricular cells Biophysical Journal. 98: 2420-2431. PMID 20513385 DOI: 10.1016/J.Bpj.2010.02.033 |
0.391 |
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| 2010 |
Xia L, Gong YL, Zhu XW, Zhang Y, Sun Q, Zhang HG. Mathematical models of canine right and left atria cardiomyocytes. Journal of Zhejiang University. Science. B. 11: 402-16. PMID 20506570 DOI: 10.1631/Jzus.B0900346 |
0.391 |
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| 2010 |
Du CY, Adeniran I, Cheng H, Zhang YH, El Harchi A, McPate MJ, Zhang H, Orchard CH, Hancox JC. Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation Journal of Cardiovascular Electrophysiology. 21: 1160-1169. PMID 20455975 DOI: 10.1111/J.1540-8167.2010.01772.X |
0.332 |
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| 2010 |
Butters TD, Aslanidi OV, Inada S, Boyett MR, Hancox JC, Lei M, Zhang H. Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome Circulation Research. 107: 126-137. PMID 20448214 DOI: 10.1161/Circresaha.110.219949 |
0.385 |
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| 2010 |
Aslanidi O, Stewart P, Boyett MR, Zhang H. Response: Optimal velocity can arise from various discontinuities Biophysical Journal. 98: 3104-3105. DOI: 10.1016/J.Bpj.2010.03.029 |
0.369 |
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| 2009 |
Law P, Kharche S, Stott J, Zhang H. Effects of elevated Homocysteine hormone on electrical activity in the human atrium: A simulation study. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 3936-9. PMID 19964086 DOI: 10.1109/IEMBS.2009.5333530 |
0.622 |
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| 2009 |
Inada S, Hancox JC, Zhang H, Boyett MR. One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells. Biophysical Journal. 97: 2117-27. PMID 19843444 DOI: 10.1016/J.Bpj.2009.06.056 |
0.401 |
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| 2009 |
Aslanidi OV, Stewart P, Boyett MR, Zhang H. Optimal velocity and safety of discontinuous conduction through the heterogeneous Purkinje-ventricular junction. Biophysical Journal. 97: 20-39. PMID 19580741 DOI: 10.1016/J.Bpj.2009.03.061 |
0.358 |
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| 2009 |
McPate MJ, Zhang H, Cordeiro JM, Dempsey CE, Witchel HJ, Hancox JC. hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome. Biochemical and Biophysical Research Communications. 386: 111-7. PMID 19501051 DOI: 10.1016/J.Bbrc.2009.05.134 |
0.311 |
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| 2009 |
Stones R, Billeter R, Zhang H, Harrison S, White E. The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts. Basic Research in Cardiology. 104: 643-52. PMID 19415411 DOI: 10.1007/S00395-009-0030-6 |
0.311 |
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| 2009 |
Stewart P, Aslanidi OV, Noble D, Noble PJ, Boyett MR, Zhang H. Mathematical models of the electrical action potential of Purkinje fibre cells. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 367: 2225-55. PMID 19414454 DOI: 10.1098/Rsta.2008.0283 |
0.44 |
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| 2009 |
El Harchi A, McPate MJ, Zhang Yh, Zhang H, Hancox JC. Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome. Journal of Molecular and Cellular Cardiology. 47: 743-7. PMID 19285083 DOI: 10.1016/J.Yjmcc.2009.02.027 |
0.34 |
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| 2009 |
Aslanidi OV, Boyett MR, Dobrzynski H, Li J, Zhang H. Mechanisms of transition from normal to reentrant electrical activity in a model of rabbit atrial tissue: interaction of tissue heterogeneity and anisotropy. Biophysical Journal. 96: 798-817. PMID 19186122 DOI: 10.1016/J.Bpj.2008.09.057 |
0.374 |
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| 2009 |
Zhang H, Tao T, Kharche S, Harrison SM. Modelling changes in transmural propagation and susceptibility to arrhythmia induced by volatile anaesthetics in ventricular tissue. Journal of Theoretical Biology. 257: 279-91. PMID 19135456 DOI: 10.1016/J.Jtbi.2008.12.004 |
0.649 |
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| 2009 |
Aslanidi OV, Benson AP, Boyett MR, Zhang H. Mechanisms of defibrillation by standing waves in the bidomain ventricular tissue with voltage applied in an external bath Physica D: Nonlinear Phenomena. 238: 984-991. DOI: 10.1016/J.Physd.2009.02.003 |
0.377 |
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| 2009 |
Zhang H, Garratt CJ, Kharche S, Holden AV. Remodelling of cellular excitation (reaction) and intercellular coupling (diffusion) by chronic atrial fibrillation represented by a reaction-diffusion system Physica D: Nonlinear Phenomena. 238: 976-983. DOI: 10.1016/J.Physd.2008.06.012 |
0.632 |
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| 2008 |
Kharche S, Zhang H. Simulating the effects of atrial fibrillation induced electrical remodeling: a comprehensive simulation study. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Conference. 593-596. PMID 19162725 |
0.626 |
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| 2008 |
Kharche S, Garratt CJ, Boyett MR, Inada S, Holden AV, Hancox JC, Zhang H. Atrial proarrhythmia due to increased inward rectifier current (IK1) arising from KCNJ2 mutation - A simulation study Progress in Biophysics and Molecular Biology. 98: 186-197. PMID 19041665 DOI: 10.1016/J.Pbiomolbio.2008.10.010 |
0.641 |
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| 2008 |
Howarth FC, Chandler NJ, Kharche S, Tellez JO, Greener ID, Yamanushi TT, Billeter R, Boyett MR, Zhang H, Dobrzynski H. Effects of streptozotocin-induced diabetes on connexin43 mRNA and protein expression in ventricular muscle. Molecular and Cellular Biochemistry. 319: 105-14. PMID 18629610 DOI: 10.1007/S11010-008-9883-5 |
0.567 |
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| 2008 |
Zhang Y, Wang T, Ma A, Zhou X, Gui J, Wan H, Shi R, Huang C, Grace AA, Huang CL, Trump D, Zhang H, Zimmer T, Lei M. Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel. Acta Physiologica (Oxford, England). 194: 311-23. PMID 18616619 DOI: 10.1111/J.1748-1716.2008.01883.X |
0.33 |
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| 2008 |
Tao T, O'Neill SC, Diaz ME, Li YT, Eisner DA, Zhang H. Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study. American Journal of Physiology. Heart and Circulatory Physiology. 295: H598-609. PMID 18515647 DOI: 10.1152/Ajpheart.01086.2007 |
0.308 |
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| 2008 |
Li J, Greener ID, Inada S, Nikolski VP, Yamamoto M, Hancox JC, Zhang H, Billeter R, Efimov IR, Dobrzynski H, Boyett MR. Computer three-dimensional reconstruction of the atrioventricular node. Circulation Research. 102: 975-85. PMID 18309098 DOI: 10.1161/Circresaha.108.172403 |
0.402 |
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| 2008 |
Gautier M, Zhang H, Fearon IM. Peroxynitrite formation mediates LPC-induced augmentation of cardiac late sodium currents. Journal of Molecular and Cellular Cardiology. 44: 241-51. PMID 17961592 DOI: 10.1016/J.Yjmcc.2007.09.007 |
0.371 |
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| 2008 |
Benson AP, Aslanidi OV, Zhang H, Holden AV. The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Progress in Biophysics and Molecular Biology. 96: 187-208. PMID 17915298 DOI: 10.1016/J.Pbiomolbio.2007.08.002 |
0.371 |
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| 2008 |
Zhang H, Kharche S, Holden AV, Hancox JC. Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation-A simulation study Progress in Biophysics and Molecular Biology. 96: 112-131. PMID 17905416 DOI: 10.1016/J.Pbiomolbio.2007.07.020 |
0.644 |
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| 2008 |
Sallé L, Kharche S, Zhang H, Brette F. Mechanisms underlying adaptation of action potential duration by pacing rate in rat myocytes Progress in Biophysics and Molecular Biology. 96: 305-320. PMID 17869329 DOI: 10.1016/J.Pbiomolbio.2007.07.008 |
0.618 |
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| 2008 |
Kharche S, Seemann G, Margetts L, Leng J, Holden AV, Zhang H. Simulation of clinical electrophysiology in 3D human atria: A high-performance computing and high-performance visualization application Concurrency Computation Practice and Experience. 20: 1317-1328. DOI: 10.1002/Cpe.V20:11 |
0.55 |
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| 2007 |
Borg JJ, Hancox JC, Zhang H, Spencer CI, Li H, Kozlowski RZ. Differential pharmacology of the cardiac anionic background current I(AB). European Journal of Pharmacology. 569: 163-70. PMID 17603033 DOI: 10.1016/J.Ejphar.2007.05.012 |
0.373 |
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| 2007 |
Taggart MJ, Blanks A, Kharche S, Holden A, Wang B, Zhang H. Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus. Bmc Pregnancy and Childbirth. 7: S3. PMID 17570163 DOI: 10.1186/1471-2393-7-S1-S3 |
0.56 |
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| 2007 |
Li H, Zhang H, Hancox JC, Kozlowski RZ. An outwardly rectifying anionic background current in atrial myocytes from the human heart Biochemical and Biophysical Research Communications. 359: 765-770. PMID 17560943 DOI: 10.1016/J.Bbrc.2007.05.177 |
0.367 |
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| 2007 |
Lei M, Zhang H, Grace AA, Huang CL. SCN5A and sinoatrial node pacemaker function. Cardiovascular Research. 74: 356-65. PMID 17368591 DOI: 10.1016/J.Cardiores.2007.01.009 |
0.35 |
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| 2007 |
Jafarnia-Dabanloo N, McLernon DC, Zhang H, Ayatollahi A, Johari-Majd V. A modified Zeeman model for producing HRV signals and its application to ECG signal generation. Journal of Theoretical Biology. 244: 180-189. PMID 16989869 DOI: 10.1016/J.Jtbi.2006.08.005 |
0.327 |
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| 2007 |
Zhang H, Zhao Y, Lei M, Dobrzynski H, Liu JH, Holden AV, Boyett MR. Computational evaluation of the roles of Na+ current, iNa, and cell death in cardiac pacemaking and driving. American Journal of Physiology. Heart and Circulatory Physiology. 292: H165-74. PMID 16877551 DOI: 10.1152/Ajpheart.01101.2005 |
0.329 |
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| 2007 |
Kharche S, Zhang H, Sallé L, Brette F. Computational investigation of the adaptation of action potential duration by pacing rate in rat myocytes Journal of Molecular and Cellular Cardiology. 42. DOI: 10.1016/J.Yjmcc.2007.03.004 |
0.558 |
|
| 2007 |
Grimstead IJ, Kharche S, Zhang H, Avis NJ, Walker DW. Viewing 0.3Tb heart simulation data at your desk Theory and Practice of Computer Graphics 2007, Tpcg 2007 - Eurographics Uk Chapter Proceedings: Celebrating 25 Years of the Eurographics Uk Chapter. 157-163. |
0.521 |
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| 2006 |
Xia L, Zhang Y, Zhang H, Wei Q, Liu F, Crozier S. Simulation of Brugada syndrome using cellular and three-dimensional whole-heart modeling approaches. Physiological Measurement. 27: 1125-42. PMID 17028406 DOI: 10.1088/0967-3334/27/11/006 |
0.427 |
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| 2006 |
Seemann G, Höper C, Sachse FB, Dössel O, Holden AV, Zhang H. Heterogeneous three-dimensional anatomical and electrophysiological model of human atria. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 364: 1465-81. PMID 16766355 DOI: 10.1098/Rsta.2006.1781 |
0.352 |
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| 2006 |
Boyett MR, Inada S, Yoo S, Li J, Liu J, Tellez J, Greener ID, Honjo H, Billeter R, Lei M, Zhang H, Efimov IR, Dobrzynski H. Connexins in the sinoatrial and atrioventricular nodes. Advances in Cardiology. 42: 175-97. PMID 16646591 DOI: 10.1159/000092569 |
0.362 |
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| 2006 |
Kharche S, Moore H, Garratt CJ, Hancox JC, Zhang H. Gain of function in Kir2.1 and its effects on atrial fibrillation in homogeneous virtual human atrial tissue: a computer simulation study Journal of Electrocardiology. 39: S83. DOI: 10.1016/J.Jelectrocard.2006.08.060 |
0.624 |
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| 2006 |
Kharche S, Moore H, Garratt CJ, Zhang H. AB31-2 Heart Rhythm. 3: S64. DOI: 10.1016/J.Hrthm.2006.02.203 |
0.508 |
|
| 2005 |
Boyett MR, Li J, Inada S, Dobrzynski H, Schneider JE, Holden AV, Zhang H. Imaging the heart: computer 3-dimensional anatomic models of the heart. Journal of Electrocardiology. 38: 113-20. PMID 16226085 DOI: 10.1016/J.Jelectrocard.2005.06.102 |
0.398 |
|
| 2005 |
Lei M, Goddard C, Liu J, Léoni AL, Royer A, Fung SS, Xiao G, Ma A, Zhang H, Charpentier F, Vandenberg JI, Colledge WH, Grace AA, Huang CL. Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. The Journal of Physiology. 567: 387-400. PMID 15932895 DOI: 10.1113/Jphysiol.2005.083188 |
0.407 |
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| 2005 |
Zhang H, Garratt CJ, Zhu J, Holden AV. Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans. Cardiovascular Research. 66: 493-502. PMID 15914114 DOI: 10.1016/J.Cardiores.2005.01.020 |
0.362 |
|
| 2005 |
Zhang H, Garratt CJ, Zhu J, Holden AV. Functional atrial conduction alternans generated by rapid FOCI in homogeneous virtual human atrial tissue Heart Rhythm. 2. DOI: 10.1016/J.Hrthm.2005.02.182 |
0.376 |
|
| 2004 |
Zhang H, Hancox JC. In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current. Biochemical and Biophysical Research Communications. 322: 693-9. PMID 15325285 DOI: 10.1016/J.Bbrc.2004.07.176 |
0.4 |
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| 2004 |
Zhang H, Holden AV. Defibrillation threshold computed from normal and supernormal excitable cardiac tissue. Bellman Prize in Mathematical Biosciences. 188: 175-190. PMID 14766101 DOI: 10.1016/J.Mbs.2003.10.003 |
0.342 |
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| 2003 |
Höper C, Seemann G, Sachse FB, Zhang H, Dössel O. 3D COMPUTER MODEL OF HUMAN ATRIAL ANATOMY AND ELECTROPHYSIOLOGY Biomedizinische Technik/Biomedical Engineering. 48: 2-3. DOI: 10.1515/Bmte.2003.48.S1.2 |
0.384 |
|
| 2003 |
Li Z, Holden AV, Orchard CH, Zhang H. Modeling excitation and propagation of action potentials across inhomogeneous ventricular tissue International Journal of Bifurcation and Chaos in Applied Sciences and Engineering. 13: 3845-3863. DOI: 10.1142/S0218127403008995 |
0.412 |
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| 2003 |
ZHANG H, GARRAT CJ, HOLDEN AV. ONSET AND TERMINATION OF REENTRANT EXCITATION IN HOMOGENEOUS HUMAN VIRTUAL ATRIAL TISSUE International Journal of Bifurcation and Chaos. 13: 3631-3643. DOI: 10.1142/S0218127403008867 |
0.408 |
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| 2003 |
Zhang H, Noble D, Cannell M, Orchard CH, Lancaster M, Jones SA, Boyett MR, Holden AV, Jafri MS, Sobie EA, Lederer WJ, Demir SS, Michailova A, Delprincipe F, Egger M, et al. Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells International Journal of Bifurcation and Chaos in Applied Sciences and Engineering. 13: 3535-3560. DOI: 10.1142/S0218127403008843 |
0.301 |
|
| 2002 |
Boyett MR, Holden AV, Zhang H. Engineering virtual cardiac tissue. Briefings in Bioinformatics. 2: 233-44. PMID 11589584 DOI: 10.1093/Bib/2.3.233 |
0.367 |
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| 2002 |
Zhang H, Holden A, Boyett M. Computational approaches to the ionic basis of pacemaker activity – from channel kinetics to the regional differences in rhythm Chaos, Solitons & Fractals. 13: 1631-1642. DOI: 10.1016/S0960-0779(01)00212-0 |
0.31 |
|
| 2001 |
Zhang H, Holden AV, Boyett MR. Gradient model versus mosaic model of the sinoatrial node. Circulation. 103: 584-8. PMID 11157726 DOI: 10.1161/01.Cir.103.4.584 |
0.304 |
|
| 2000 |
Zhang H, Holden AV, Kodama I, Honjo H, Lei M, Varghese T, Boyett MR. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. American Journal of Physiology. Heart and Circulatory Physiology. 279: H397-421. PMID 10899081 DOI: 10.1152/Ajpheart.2000.279.1.H397 |
0.382 |
|
| 1998 |
Zhang H, Winslow R, Holden AV. Re-entrant Excitation Initiated in Models of Inhomogeneous Atrial Tissue Journal of Theoretical Biology. 191: 279-287. PMID 9631568 DOI: 10.1006/Jtbi.1997.0598 |
0.346 |
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| 1997 |
Zhang H, Holden AV. One-dimensional modelling of the vulnerability to re-entry of homogeneous atrial tissue. Journal of Theoretical Biology. 184: 117-122. PMID 9059591 DOI: 10.1006/Jtbi.1996.0280 |
0.383 |
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| 1997 |
Biktashev VN, Holden AV, Zhang H. A Model for the Action of External Current onto Excitable Tissue International Journal of Bifurcation and Chaos. 7: 477-485. DOI: 10.1142/S0218127497000364 |
0.364 |
|
| 1995 |
Holden AV, Zhang H. Characteristics of atrial re-entry and meander computed from a model of a rabbit single atrial cell. Journal of Theoretical Biology. 175: 545-551. PMID 7475090 DOI: 10.1006/Jtbi.1995.0162 |
0.376 |
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| 1995 |
Zhang H, Patel N. Spiral wave breakdown in an excitable medium model of cardiac tissue Chaos Solitons & Fractals. 5: 635-643. DOI: 10.1016/0960-0779(93)E0046-E |
0.358 |
|
| 1995 |
Boyett M, Holden AV, Kodama I, Suzuki R, Zhang H. Atrial modulation of sinoatrial pacemaker rate Chaos Solitons & Fractals. 5: 425-438. DOI: 10.1016/0960-0779(93)E0034-9 |
0.378 |
|
| 1993 |
Holden AV, Zhang H. Modelling propagation and re-entry in anisotropic and smoothly heterogeneous cardiac tissue Journal of the Chemical Society, Faraday Transactions. 89: 2833-2837. DOI: 10.1039/Ft9938902833 |
0.352 |
|
| 1992 |
Zhang H, Holden AV, Lab M, Moutoussis M. Estimation of the persistence of strain from experimental recordings from cardiac tissue Physica D: Nonlinear Phenomena. 58: 489-496. DOI: 10.1016/0167-2789(92)90134-9 |
0.349 |
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