Christopher S. Leonard, Ph.D. - Publications

Physiology New York Medical College, New York, NY, United States 
Neurophysiology, Cellular basis of sleeping and waking, cholinergic and monoaminergic brain systems, orexin (hypocretin), Patch Clamp, Ca2+ imaging, Brain slices

45/67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cissé Y, Ishibashi M, Jost J, Toossi H, Mainville L, Adamantidis A, Leonard CS, Jones BE. Discharge and Role of GABA Pontomesencephalic Neurons in Cortical Activity and Sleep-Wake States Examined by Optogenetics and Juxtacellular Recordings in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32576622 DOI: 10.1523/JNEUROSCI.2875-19.2020  1
2018 Cissé Y, Toossi H, Ishibashi M, Mainville L, Leonard CS, Adamantidis A, Jones BE. Discharge and Role of Acetylcholine Pontomesencephalic Neurons in Cortical Activity and Sleep-Wake States Examined by Optogenetics and Juxtacellular Recording in Mice. Eneuro. 5. PMID 30225352 DOI: 10.1523/ENEURO.0270-18.2018  1
2016 Ishibashi M, Gumenchuk I, Miyazaki K, Inoue T, Ross WN, Leonard CS. Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10097-115. PMID 27683906 DOI: 10.1523/JNEUROSCI.0635-16.2016  1
2015 Ishibashi M, Gumenchuk I, Kang B, Steger C, Lynn E, Molina NE, Eisenberg LM, Leonard CS. Orexin Receptor Activation Generates Gamma Band Input to Cholinergic and Serotonergic Arousal System Neurons and Drives an Intrinsic Ca(2+)-Dependent Resonance in LDT and PPT Cholinergic Neurons. Frontiers in Neurology. 6: 120. PMID 26082752 DOI: 10.3389/fneur.2015.00120  1
2015 Leonard CS, Ishibashi M. Orexin receptor functions in the ascending arousal system Orexin and Sleep: Molecular, Functional and Clinical Aspects. 67-80. DOI: 10.1007/978-3-319-23078-8_5  1
2014 Christensen MH, Ishibashi M, Nielsen ML, Leonard CS, Kohlmeier KA. Age-related changes in nicotine response of cholinergic and non-cholinergic laterodorsal tegmental neurons: implications for the heightened adolescent susceptibility to nicotine addiction. Neuropharmacology. 85: 263-83. PMID 24863041 DOI: 10.1016/j.neuropharm.2014.05.010  1
2014 Kukkonen JP, Leonard CS. Orexin/hypocretin receptor signalling cascades. British Journal of Pharmacology. 171: 314-31. PMID 23902572 DOI: 10.1111/bph.12324  1
2014 Leonard CS, Kukkonen JP. Orexin/hypocretin receptor signalling: a functional perspective. British Journal of Pharmacology. 171: 294-313. PMID 23848055 DOI: 10.1111/bph.12296  1
2013 Kohlmeier KA, Tyler CJ, Kalogiannis M, Ishibashi M, Kristensen MP, Gumenchuk I, Chemelli RM, Kisanuki YY, Yanagisawa M, Leonard CS. Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy. Frontiers in Neuroscience. 7: 246. PMID 24391530 DOI: 10.3389/fnins.2013.00246  1
2012 Kohlmeier KA, Ishibashi M, Wess J, Bickford ME, Leonard CS. Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus. Journal of Neurophysiology. 108: 2751-66. PMID 22956788 DOI: 10.1152/jn.01120.2011  1
2011 Kalogiannis M, Hsu E, Willie JT, Chemelli RM, Kisanuki YY, Yanagisawa M, Leonard CS. Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. Plos One. 6: e18697. PMID 21533254 DOI: 10.1371/journal.pone.0018697  1
2010 Kalogiannis M, Grupke SL, Potter PE, Edwards JG, Chemelli RM, Kisanuki YY, Yanagisawa M, Leonard CS. Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. The European Journal of Neuroscience. 32: 130-42. PMID 20576035 DOI: 10.1111/j.1460-9568.2010.07259.x  1
2009 Ishibashi M, Leonard CS, Kohlmeier KA. Nicotinic activation of laterodorsal tegmental neurons: implications for addiction to nicotine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2529-47. PMID 19625996 DOI: 10.1038/npp.2009.82  1
2008 Kohlmeier KA, Watanabe S, Tyler CJ, Burlet S, Leonard CS. Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. Journal of Neurophysiology. 100: 2265-81. PMID 18667550 DOI: 10.1152/jn.01388.2007  1
2006 Kohlmeier KA, Leonard CS. Transmitter modulation of spike-evoked calcium transients in arousal related neurons: muscarinic inhibition of SNX-482-sensitive calcium influx. The European Journal of Neuroscience. 23: 1151-62. PMID 16553779 DOI: 10.1111/j.1460-9568.2006.04640.x  1
2005 Clark SD, Nothacker HP, Blaha CD, Tyler CJ, Duangdao DM, Grupke SL, Helton DR, Leonard CS, Civelli O. Urotensin II acts as a modulator of mesopontine cholinergic neurons. Brain Research. 1059: 139-48. PMID 16183039 DOI: 10.1016/j.brainres.2005.08.026  1
2005 Huitron-Resendiz S, Kristensen MP, Sánchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5465-74. PMID 15944374 DOI: 10.1523/JNEUROSCI.4501-04.2005  1
2005 Goldberg EM, Watanabe S, Chang SY, Joho RH, Huang ZJ, Leonard CS, Rudy B. Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5230-5. PMID 15917463 DOI: 10.1523/JNEUROSCI.0722-05.2005  1
2005 Leonard CS, Tyler CJ, Burlet S, Watanabe S, Kohlmeier KA. Hypocretin/orexin actions on mesopontine cholinergic systems controling behavioral state Hypocretins: Integrators of Physiological Functions. 153-168. DOI: 10.1007/0-387-25446-3_10  1
2004 Kohlmeier KA, Inoue T, Leonard CS. Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. Journal of Neurophysiology. 92: 221-35. PMID 14999052 DOI: 10.1152/jn.00076.2004  1
2003 Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron. 38: 715-30. PMID 12797957 DOI: 10.1016/S0896-6273(03)00330-1  1
2002 Burlet S, Tyler CJ, Leonard CS. Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2862-72. PMID 11923451  1
2001 Leonard CS, Michaelis EK, Mitchell KM. Activity-dependent nitric oxide concentration dynamics in the laterodorsal tegmental nucleus in vitro. Journal of Neurophysiology. 86: 2159-72. PMID 11698508  1
2000 Lau D, Vega-Saenz de Miera EC, Contreras D, Ozaita A, Harvey M, Chow A, Noebels JL, Paylor R, Morgan JI, Leonard CS, Rudy B. Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 9071-85. PMID 11124984  1
2000 Leonard CS, Rao SR, Inoue T. Serotonergic inhibition of action potential evoked calcium transients in NOS-containing mesopontine cholinergic neurons. Journal of Neurophysiology. 84: 1558-72. PMID 10980027  1
1999 Erisir A, Lau D, Rudy B, Leonard CS. Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons. Journal of Neurophysiology. 82: 2476-89. PMID 10561420  1
1999 Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E. Contributions of Kv3 channels to neuronal excitability. Annals of the New York Academy of Sciences. 868: 304-43. PMID 10414303 DOI: 10.1111/j.1749-6632.1999.tb11295.x  1
1998 Surkis A, Peskin CS, Tranchina D, Leonard CS. Recovery of cable properties through active and passive modeling of subthreshold membrane responses from laterodorsal tegmental neurons. Journal of Neurophysiology. 80: 2593-607. PMID 9819266  1
1998 Lubin M, Leonard CS, Aoki C. Preservation of ultrastructure and antigenicity for EM immunocytochemistry following intracellular recording and labeling of single cortical neurons in brain slices. Journal of Neuroscience Methods. 81: 91-102. PMID 9696314 DOI: 10.1016/S0165-0270(98)00022-3  1
1998 Sanchez RM, Surkis A, Leonard CS. Voltage-clamp analysis and computer simulation of a novel cesium-resistant A-current in guinea pig laterodorsal tegmental neurons. Journal of Neurophysiology. 79: 3111-26. PMID 9636112  1
1996 Carandini M, Mechler F, Leonard CS, Movshon JA. Spike train encoding by regular-spiking cells of the visual cortex. Journal of Neurophysiology. 76: 3425-41. PMID 8930283  1
1996 Sanchez R, Leonard CS. NMDA-receptor-mediated synaptic currents in guinea pig laterodorsal tegmental neurons in vitro. Journal of Neurophysiology. 76: 1101-11. PMID 8871223  1
1996 Surkis A, Taylor B, Peskin CS, Leonard CS. Quantitative morphology of physiologically identified and intracellularly labeled neurons from the guinea-pig laterodorsal tegmental nucleus in vitro. Neuroscience. 74: 375-92. PMID 8865190 DOI: 10.1016/0306-4522(96)00139-X  1
1995 Leonard CS, Kerman I, Blaha G, Taveras E, Taylor B. Interdigitation of nitric oxide synthase-, tyrosine hydroxylase-, and serotonin-containing neurons in and around the laterodorsal and pedunculopontine tegmental nuclei of the guinea pig. The Journal of Comparative Neurology. 362: 411-32. PMID 8576448 DOI: 10.1002/cne.903620309  1
1995 Leonard CS, Rao S, Sanchez RM. Patterns of neuromodulation and the nitric oxide signaling pathway in mesopontine cholinergic neurons Seminars in the Neurosciences. 7: 319-328. DOI: 10.1006/smns.1995.0035  1
1994 Leonard CS, Llinás R. Serotonergic and cholinergic inhibition of mesopontine cholinergic neurons controlling REM sleep: an in vitro electrophysiological study. Neuroscience. 59: 309-30. PMID 8008195 DOI: 10.1016/0306-4522(94)90599-1  1
1994 Sanchez R, Leonard CS. NMDA receptor-mediated synaptic input to nitric oxide synthase-containing neurons of the guinea pig mesopontine tegmentum in vitro. Neuroscience Letters. 179: 141-4. PMID 7531311 DOI: 10.1016/0304-3940(94)90954-7  1
1994 De Zeeuw CI, Gerrits NM, Voogd J, Leonard CS, Simpson JI. The rostral dorsal cap and ventrolateral outgrowth of the rabbit inferior olive receive a GABAergic input from dorsal group Y and the ventral dentate nucleus. The Journal of Comparative Neurology. 341: 420-32. PMID 7515083 DOI: 10.1002/cne.903410311  1
1989 Simpson JI, Van der Steen J, Tan J, Graf W, Leonard CS. Representations of ocular rotations in the cerebellar flocculus of the rabbit. Progress in Brain Research. 80: 213-23; discussion 2. PMID 2634272  1
1988 Simpson JI, Leonard CS, Soodak RE. The accessory optic system. Analyzer of self-motion. Annals of the New York Academy of Sciences. 545: 170-9. PMID 3239883  1
1988 Graf W, Simpson JI, Leonard CS. Spatial organization of visual messages of the rabbit's cerebellar flocculus. II. Complex and simple spike responses of Purkinje cells. Journal of Neurophysiology. 60: 2091-121. PMID 3236063  1
1988 Leonard CS, Simpson JI, Graf W. Spatial organization of visual messages of the rabbit's cerebellar flocculus. I. Typology of inferior olive neurons of the dorsal cap of Kooy. Journal of Neurophysiology. 60: 2073-90. PMID 3236062  1
1988 Simpson JI, Leonard CS, Soodak RE. The accessory optic system of rabbit. II. Spatial organization of direction selectivity. Journal of Neurophysiology. 60: 2055-72. PMID 3236061  1
1986 Leonard CS, Simpson JI. Microinjections of local anesthetic to effect rapid, reversible lesions of central structures Journal of Neuroscience Methods. 17: 205-206. DOI: 10.1016/0165-0270(86)90091-9  1
1985 Llinás R, McGuinness TL, Leonard CS, Sugimori M, Greengard P. Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proceedings of the National Academy of Sciences of the United States of America. 82: 3035-9. PMID 2859595 DOI: 10.1073/pnas.82.9.3035  1
Low-probability matches
2017 Ma S, Hangya B, Leonard CS, Wisden W, Gundlach AL. Dual-transmitter systems regulating arousal, attention, learning and memory. Neuroscience and Biobehavioral Reviews. PMID 28757457 DOI: 10.1016/j.neubiorev.2017.07.009  0.04
2015 Ilina I, Leonard CS, Plisetskiy E. Russian regional resilience: Cooperation and resource abundance: A case study of khanty-mansi autonomous Okrug The Challenges For Russia's Politicized Economic System. 220-237.  0.01
2014 Tarrago R, Nowak JE, Leonard CS, Payne NR. Reductions in invasive device use and care costs after institution of a daily safety checklist in a pediatric critical care unit. Joint Commission Journal On Quality and Patient Safety / Joint Commission Resources. 40: 270-8. PMID 25016675  0.01
2013 Leonard CS, Pitt-Watson D. Privatization and transition in Russia in the early 1990s Privatization and Transition in Russia in the Early 1990s. 1-193. DOI: 10.4324/9780203766828  0.01
2012 Leonard CS. Rational Resistance to Land Privatization: The Behaviour of Russia's Rural Producers in Response to Agrarian Reforms, 1861-2000 The Economic Future in Historical Perspective. DOI: 10.5871/bacad/9780197263471.003.0009  0.01
2010 Leonard CS. Agrarian reform in Russia: The road from serfdom Agrarian Reform in Russia: the Road From Serfdom. 1-402. DOI: 10.1017/CBO9780511780639  0.01
2010 Granville B, Leonard CS. Do Informal Institutions Matter for Technological Change in Russia? The Impact of Communist Norms and Conventions, 1998-2004 World Development. 38: 155-169. DOI: 10.1016/j.worlddev.2009.10.010  0.01
2008 Borodkin L, Granville B, Leonard CS. The rural/urban wage gap in the industrialisation of Russia, 1884-1910 European Review of Economic History. 12: 67-95. DOI: 10.1017/S1361491608002116  0.01
2008 Egert B, Leonard CS. Dutch disease scare in kazakhstan: Is it real? Open Economies Review. 19: 147-165. DOI: 10.1007/s11079-007-9051-7  0.01
2007 Égert B, Leonard CS. Nominal and real exchange rates in Kazakhstan: Any sign of Dutch disease? The Economics and Politics of Oil in the Caspian Basin: the Redistribution of Oil Revenues in Azerbaijan and Central Asia. 45-63. DOI: 10.4324/9780203940549  0.01
2000 Leonard CS. Rational resistance to land privatization: The response of rural producers to agrarian reforms in pre- and post-Soviet Russia Post-Soviet Geography and Economics. 41: 605-620.  0.01
1995 Ashcroft GP, Hutchison JD, Porter RW, Roditi GH, Evans NTS, Mikecz P, Chaloner F, Cyclotron MD, Leonard C, Sharp PF, Smith FW. I measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography Spine. 20: 408-411. PMID 7747223 DOI: 10.1097/00007632-199502001-00002  0.01
1966 Berry HK, Leonard CS. Plasma amino acids in full-term infants. The American Journal of Clinical Nutrition. 19: 99-104. PMID 5916039  0.01
1950 BONNYCASTLE DD, LEONARD CS. An estimation of the activity of analgetic materials. The Journal of Pharmacology and Experimental Therapeutics. 100: 141-5. PMID 14784950  0.01
1949 DREYER NB, LEONARD CS. Effects of mercury salts on the composition of the gastric juice. Archives Internationales De Pharmacodynamie Et De ThéRapie. 78: 86-92. PMID 18124422  0.01
1948 LEONARD CS. Influence of oxophenarsine on hypoglycemic action of insulin. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 67: 89-92. PMID 18902303 DOI: 10.3181/00379727-67-16214  0.01
1946 LEONARD CS. The problem of the role of sulfhydryl enzymes in the mechanism of the action of certain chemotherapeutic agents. Bulletin. American Pharmaceutical Association. Committee On National Formulary. 14: 139-49. PMID 20285805  0.01
1946 Leonard CS. The Immunizing Effect in the Action of Trypanocidal Agents. Science (New York, N.Y.). 104: 556. PMID 17840545 DOI: 10.1126/science.104.2710.556  0.01
1946 Leonard CS. Lack of Influence of Thiosulfate and Metabisulfite on the Antibiotic Activity of Penicillin. Science (New York, N.Y.). 104: 501-2. PMID 17743262 DOI: 10.1126/science.104.2709.501  0.01
1931 Buck JS, Leonard CS. Rhodanines. I. Derivatives of β-phenylethylamines Journal of the American Chemical Society. 53: 2688-2692.  0.01
1925 Leonard CS. Synthesis of phenylethyl alcohol Journal of the American Chemical Society. 47: 1774-1779.  0.01
1921 Leonard CS. Some compounds of piperidine with halides Journal of the American Chemical Society. 43: 2618-2626.  0.01
Hide low-probability matches.