Huda Akil - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
stress and depression, endorphins
Website:
http://www.umich.edu/~neurosci/faculty/akil.htm

361 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hebda-Bauer EK, Dokas LA, Watson SJ, Akil H. Adaptation to single housing is dynamic: Changes in hormone levels, gene expression, signaling in the brain, and anxiety-like behavior in adult male C57Bl/6J mice. Hormones and Behavior. PMID 31220462 DOI: 10.1016/j.yhbeh.2019.06.005  1
2019 Zhou Z, Blandino P, Yuan Q, Shen PH, Hodgkinson CA, Virkkunen M, Watson SJ, Akil H, Goldman D. Exploratory locomotion, a predictor of addiction vulnerability, is oligogenic in rats selected for this phenotype. Proceedings of the National Academy of Sciences of the United States of America. PMID 31182603 DOI: 10.1073/pnas.1820410116  1
2019 Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, ... ... Akil H, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. PMID 31043756 DOI: 10.1038/s41588-019-0397-8  1
2019 Langenecker SA, Mickey BJ, Eichhammer P, Sen S, Elverman KH, Kennedy SE, Heitzeg MM, Ribeiro SM, Love TM, Hsu DT, Koeppe RA, Watson SJ, Akil H, Goldman D, Burmeister M, et al. Cognitive Control as a 5-HT-Based Domain That Is Disrupted in Major Depressive Disorder. Frontiers in Psychology. 10: 691. PMID 30984083 DOI: 10.3389/fpsyg.2019.00691  1
2019 Turner CA, Hagenauer MH, Aurbach EL, Maras PM, Fournier CL, Blandino P, Chauhan RB, Panksepp J, Watson SJ, Akil H. Effects of early-life FGF2 on ultrasonic vocalizations (USVs) and the mu-opioid receptor in male Sprague-Dawley rats selectively-bred for differences in their response to novelty. Brain Research. PMID 30880118 DOI: 10.1016/j.brainres.2019.03.011  1
2019 Hjelm BE, Rollins B, Morgan L, Sequeira A, Mamdani F, Pereira F, Damas J, Webb MG, Weber MD, Schatzberg AF, Barchas JD, Lee FS, Akil H, Watson SJ, Myers RM, et al. Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders. Nucleic Acids Research. PMID 30869147 DOI: 10.1093/nar/gkz164  1
2019 Mccoy CR, Glover ME, Flynn LT, Simmons RK, Cohen JL, Ptacek T, Lefkowitz EJ, Jackson NL, Akil H, Wu X, Clinton SM. Altered DNA Methylation in the Developing Brains of Rats Genetically Prone to High Versus Low Anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30683683 DOI: 10.1523/JNEUROSCI.1157-15.2019  1
2018 Wei Q, Krolewski DM, Moore S, Kumar V, Li F, Martin B, Tomer R, Murphy GG, Deisseroth K, Watson SJ, Akil H. Uneven balance of power between hypothalamic peptidergic neurons in the control of feeding. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224492 DOI: 10.1073/pnas.1802237115  1
2018 Hagenauer MH, Schulmann A, Li JZ, Vawter MP, Walsh DM, Thompson RC, Turner CA, Bunney WE, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H. Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis. Plos One. 13: e0200003. PMID 30016334 DOI: 10.1371/journal.pone.0200003  1
2018 Turner CA, Sharma V, Hagenauer MH, Chaudhury S, O'Connor AM, Hebda-Bauer EK, Thompson RC, Myers RM, Bunney WE, Barchas JD, Lee FS, Schatzberg AF, Watson SJ, Akil H. Connective Tissue Growth Factor Is a Novel Prodepressant. Biological Psychiatry. PMID 29861095 DOI: 10.1016/j.biopsych.2018.04.013  1
2018 Turner CA, Lyons DM, Buckmaster CL, Aurbach EL, Watson SJ, Schatzberg AF, Akil H. Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29703997 DOI: 10.1038/s41386-018-0052-6  1
2018 Rollins BL, Morgan L, Hjelm BE, Sequeira A, Schatzberg AF, Barchas JD, Lee FS, Myers RM, Watson SJ, Akil H, Potkin SG, Bunney WE, Vawter MP. Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence. Molecular Neuropsychiatry. 3: 157-169. PMID 29594135 DOI: 10.1159/000484348  1
2017 Gupta S, M-Redmond T, Meng F, Tidball A, Akil H, Watson S, Parent JM, Uhler M. Fibroblast Growth Factor 2 Regulates Activity and Gene Expression of Human Postmitotic Excitatory Neurons. Journal of Neurochemistry. PMID 29168882 DOI: 10.1111/jnc.14255  0.96
2017 Mabrouk OS, Han JL, Wong JT, Akil H, Kennedy RT, Flagel SB. In vivo neurochemical profile of selectively bred high-responder and low-responder rats reveals baseline, cocaine- and novelty-evoked differences in monoaminergic systems. Acs Chemical Neuroscience. PMID 29161023 DOI: 10.1021/acschemneuro.7b00294  1
2017 Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, et al. Building Bridges through Science. Neuron. 96: 730-735. PMID 29144972 DOI: 10.1016/j.neuron.2017.09.028  0.64
2017 Lee AG, Hagenauer M, Absher D, Morrison KE, Bale TL, Myers RM, Watson SJ, Akil H, Schatzberg AF, Lyons DM. Stress amplifies sex differences in primate prefrontal profiles of gene expression. Biology of Sex Differences. 8: 36. PMID 29096718 DOI: 10.1186/s13293-017-0157-3  1
2017 Turner CA, Flagel SB, Blandino P, Watson SJ, Akil H. Utilizing a unique animal model to better understand human temperament. Current Opinion in Behavioral Sciences. 14: 108-114. PMID 28966969 DOI: 10.1016/j.cobeha.2017.02.002  1
2017 Ramaker RC, Bowling KM, Lasseigne BN, Hagenauer MH, Hardigan AA, Davis NS, Gertz J, Cartagena PM, Walsh DM, Vawter MP, Jones EG, Schatzberg AF, Barchas JD, Watson SJ, Bunney BG, ... Akil H, et al. Post-mortem molecular profiling of three psychiatric disorders. Genome Medicine. 9: 72. PMID 28754123 DOI: 10.1186/s13073-017-0458-5  1
2017 García-Fuster MJ, Parsegian A, Watson SJ, Akil H, Flagel SB. Adolescent cocaine exposure enhances goal-tracking behavior and impairs hippocampal cell genesis selectively in adult bred low-responder rats. Psychopharmacology. PMID 28210781 DOI: 10.1007/s00213-017-4566-0  1
2017 Prater KE, Aurbach EL, Larcinese HK, Smith TN, Turner CA, Blandino P, Watson SJ, Maren S, Akil H. Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28205604 DOI: 10.1038/npp.2017.37  1
2016 Litvin Y, Turner CA, Rios MB, Maras PM, Chaudhury S, Baker MR, Blandino P, Watson SJ, Akil H, McEwen B. Fibroblast growth factor 2 alters the oxytocin receptor in a developmental model of anxiety-like behavior in male rat pups. Hormones and Behavior. 86: 64-70. PMID 27693608 DOI: 10.1016/j.yhbeh.2016.09.009  1
2016 Morgan LZ, Rollins B, Sequeira A, Byerley W, DeLisi LE, Schatzberg AF, Barchas JD, Myers RM, Watson SJ, Akil H, Bunney WE, Vawter MP. Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders. Microarrays (Basel, Switzerland). 5. PMID 27600072 DOI: 10.3390/microarrays5010006  1
2016 Turner CA, Watson SJ, Akil H. Fibroblast Growth Factor 2 Sits at the Interface of Stress and Anxiety. Biological Psychiatry. 80: 419-21. PMID 27565541 DOI: 10.1016/j.biopsych.2016.07.010  1
2016 Azevedo JA, Carter BS, Meng F, Turner DL, Dai M, Schatzberg AF, Barchas JD, Jones EG, Bunney WE, Myers RM, Akil H, Watson SJ, Thompson RC. The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression. Journal of Psychiatric Research. 82: 58-67. PMID 27468165 DOI: 10.1016/j.jpsychires.2016.07.012  1
2016 Akil H, Balice-Gordon R, Cardozo DL, Koroshetz W, Posey Norris SM, Sherer T, Sherman SM, Thiels E. Neuroscience Training for the 21st Century. Neuron. 90: 917-26. PMID 27253446 DOI: 10.1016/j.neuron.2016.05.030  1
2016 Flagel SB, Chaudhury S, Waselus M, Kelly R, Sewani S, Clinton SM, Thompson RC, Watson SJ, Akil H. Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114539 DOI: 10.1073/pnas.1520491113  0.92
2016 Morgan LZ, Rollins B, Sequeira A, Byerley W, DeLisi LE, Schatzberg AF, Barchas JD, Myers RM, Watson SJ, Akil H, Bunney WE, Vawter MP. Quantitative Trait Locus and Brain Expression of HLA-DPA1 Offers Evidence of Shared Immune Alterations in Psychiatric Disorders. Microarrays (Basel, Switzerland). 5. PMID 26998349 DOI: 10.3390/microarrays5010006  1
2015 Medina A, Watson SJ, Bunney W, Myers RM, Schatzberg A, Barchas J, Akil H, Thompson RC. Evidence for alterations of the glial syncytial function in major depressive disorder. Journal of Psychiatric Research. 72: 15-21. PMID 26519765 DOI: 10.1016/j.jpsychires.2015.10.010  0.52
2015 Rana S, Nam H, Glover ME, Akil H, Watson SJ, Clinton SM, Kerman IA. Protective Effects of Chronic Mild Stress during Adolescence in the Low Novelty Responder Rat. Stress (Amsterdam, Netherlands). 1-18. PMID 26473581 DOI: 10.3109/10253890.2015.1108304  0.52
2015 Turner CA, Eren-Koçak E, Inui EG, Watson SJ, Akil H. Dysregulated fibroblast growth factor (FGF) signaling in neurological and psychiatric disorders. Seminars in Cell & Developmental Biology. PMID 26454097 DOI: 10.1016/j.semcdb.2015.10.003  0.52
2015 Mamdani F, Rollins B, Morgan L, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Potkin SG, Bunney WE, Vawter MP, Sequeira PA. Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder. Translational Psychiatry. 5: e636. PMID 26371764 DOI: 10.1038/tp.2015.134  1
2015 Aurbach EL, Inui EG, Turner CA, Hagenauer MH, Prater KE, Li JZ, Absher D, Shah N, Blandino P, Bunney WE, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H. Fibroblast growth factor 9 is a novel modulator of negative affect. Proceedings of the National Academy of Sciences of the United States of America. 112: 11953-8. PMID 26351673 DOI: 10.1073/pnas.1510456112  1
2015 Haight JL, Fraser KM, Akil H, Flagel SB. Lesions of the paraventricular nucleus of the thalamus differentially affect sign- and goal-tracking conditioned responses. The European Journal of Neuroscience. 42: 2478-88. PMID 26228683 DOI: 10.1111/ejn.13031  0.8
2015 Sequeira A, Rollins B, Magnan C, van Oven M, Baldi P, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Vawter MP. Mitochondrial mutations in subjects with psychiatric disorders. Plos One. 10: e0127280. PMID 26011537 DOI: 10.1371/journal.pone.0127280  1
2015 Cohen JL, Glover ME, Pugh PC, Fant AD, Simmons RK, Akil H, Kerman IA, Clinton SM. Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High Anxiety. Developmental Neuroscience. 37: 203-14. PMID 25791846 DOI: 10.1159/000374108  1
2015 Robinson MJ, Burghardt PR, Patterson CM, Nobile CW, Akil H, Watson SJ, Berridge KC, Ferrario CR. Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2113-23. PMID 25761571 DOI: 10.1038/npp.2015.71  1
2015 Glover ME, Pugh PC, Jackson NL, Cohen JL, Fant AD, Akil H, Clinton SM. Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats. Neuroscience. 284: 775-97. PMID 25451292 DOI: 10.1016/j.neuroscience.2014.10.044  1
2015 Bunney BG, Li JZ, Walsh DM, Stein R, Vawter MP, Cartagena P, Barchas JD, Schatzberg AF, Myers RM, Watson SJ, Akil H, Bunney WE. Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder. Molecular Psychiatry. 20: 48-55. PMID 25349171 DOI: 10.1038/mp.2014.138  1
2014 Chaudhury S, Aurbach EL, Sharma V, Blandino P, Turner CA, Watson SJ, Akil H. FGF2 is a target and a trigger of epigenetic mechanisms associated with differences in emotionality: partnership with H3K9me3. Proceedings of the National Academy of Sciences of the United States of America. 111: 11834-9. PMID 25071177 DOI: 10.1073/pnas.1411618111  1
2014 Turner CA, Thompson RC, Bunney WE, Schatzberg AF, Barchas JD, Myers RM, Akil H, Watson SJ. Altered choroid plexus gene expression in major depressive disorder. Frontiers in Human Neuroscience. 8: 238. PMID 24795602 DOI: 10.3389/fnhum.2014.00238  1
2014 Hamilton DE, Cooke CL, Carter BS, Akil H, Watson SJ, Thompson RC. Basal microRNA expression patterns in reward circuitry of selectively bred high-responder and low-responder rats vary by brain region and genotype. Physiological Genomics. 46: 290-301. PMID 24569673 DOI: 10.1152/physiolgenomics.00152.2013  1
2014 Guella I, Sequeira A, Rollins B, Morgan L, Myers RM, Watson SJ, Akil H, Bunney WE, Delisi LE, Byerley W, Vawter MP. Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. Schizophrenia Research. 152: 111-6. PMID 24315717 DOI: 10.1016/j.schres.2013.11.021  1
2014 Clinton SM, Watson SJ, Akil H. High novelty-seeking rats are resilient to negative physiological effects of the early life stress. Stress (Amsterdam, Netherlands). 17: 97-107. PMID 24090131 DOI: 10.3109/10253890.2013.850670  1
2014 Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H. Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology. 76: 425-36. PMID 23639434 DOI: 10.1016/j.neuropharm.2013.04.033  1
2013 Tomita H, Ziegler ME, Kim HB, Evans SJ, Choudary PV, Li JZ, Meng F, Dai M, Myers RM, Neal CR, Speed TP, Barchas JD, Schatzberg AF, Watson SJ, Akil H, et al. G protein-linked signaling pathways in bipolar and major depressive disorders. Frontiers in Genetics. 4: 297. PMID 24391664 DOI: 10.3389/fgene.2013.00297  1
2013 Ballaz SJ, Perez J, Waselus M, Akil H, Watson SJ. Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats. Neuroscience. 255: 68-75. PMID 24121132 DOI: 10.1016/j.neuroscience.2013.09.063  1
2013 Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics. 45: 984-94. PMID 23933821 DOI: 10.1038/ng.2711  1
2013 Waselus M, Flagel SB, Jedynak JP, Akil H, Robinson TE, Watson SJ. Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats. Neuroscience. 248: 571-84. PMID 23811073 DOI: 10.1016/j.neuroscience.2013.06.042  1
2013 Perez-Sepulveda JA, Flagel SB, Garcia-Fuster MJ, Slusky RJ, Aldridge JW, Watson S, Akil H. Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality. Neuroscience. 248: 436-47. PMID 23806722 DOI: 10.1016/j.neuroscience.2013.06.015  1
2013 Guella I, Sequeira A, Rollins B, Morgan L, Torri F, van Erp TG, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H, Bunney WE, Potkin SG, Macciardi F, Vawter MP. Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex. Journal of Psychiatric Research. 47: 1215-21. PMID 23786914 DOI: 10.1016/j.jpsychires.2013.05.021  1
2013 Medina A, Burke S, Thompson RC, Bunney W, Myers RM, Schatzberg A, Akil H, Watson SJ. Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder. Journal of Psychiatric Research. 47: 1150-6. PMID 23706640 DOI: 10.1016/j.jpsychires.2013.04.007  1
2013 Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, Evans SJ, Choudary PV, Cartagena P, Barchas JD, Schatzberg AF, Jones EG, Myers RM, Watson SJ, Akil H, et al. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proceedings of the National Academy of Sciences of the United States of America. 110: 9950-5. PMID 23671070 DOI: 10.1073/pnas.1305814110  1
2013 Cummings JA, Clinton SM, Perry AN, Akil H, Becker JB. Male rats that differ in novelty exploration demonstrate distinct patterns of sexual behavior. Behavioral Neuroscience. 127: 47-58. PMID 23398441 DOI: 10.1037/a0031528  1
2013 Medina A, Seasholtz AF, Sharma V, Burke S, Bunney W, Myers RM, Schatzberg A, Akil H, Watson SJ. Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder. Journal of Psychiatric Research. 47: 307-14. PMID 23219281 DOI: 10.1016/j.jpsychires.2012.11.002  1
2013 Hebda-Bauer EK, Simmons TA, Sugg A, Ural E, Stewart JA, Beals JL, Wei Q, Watson SJ, Akil H. 3xTg-AD mice exhibit an activated central stress axis during early-stage pathology. Journal of Alzheimer's Disease : Jad. 33: 407-22. PMID 22976078 DOI: 10.3233/JAD-2012-121438  1
2012 Kerman IA, Bernard R, Bunney WE, Jones EG, Schatzberg AF, Myers RM, Barchas JD, Akil H, Watson SJ, Thompson RC. Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder. Frontiers in Neuroscience. 6: 135. PMID 23087602 DOI: 10.3389/fnins.2012.00135  1
2012 Turner CA, Watson SJ, Akil H. The fibroblast growth factor family: neuromodulation of affective behavior. Neuron. 76: 160-74. PMID 23040813 DOI: 10.1016/j.neuron.2012.08.037  1
2012 García-Fuster MJ, Flagel SB, Mahmood ST, Watson SJ, Akil H. Cocaine withdrawal causes delayed dysregulation of stress genes in the hippocampus. Plos One. 7: e42092. PMID 22860061 DOI: 10.1371/journal.pone.0042092  1
2012 Turner CA, Watson SJ, Akil H. Fibroblast growth factor-2: an endogenous antidepressant and anxiolytic molecule? Biological Psychiatry. 72: 254-5. PMID 22840947 DOI: 10.1016/j.biopsych.2012.05.025  1
2012 Clinton SM, Turner CA, Flagel SB, Simpson DN, Watson SJ, Akil H. Neonatal fibroblast growth factor treatment enhances cocaine sensitization. Pharmacology, Biochemistry, and Behavior. 103: 6-17. PMID 22819969 DOI: 10.1016/j.pbb.2012.07.006  1
2012 Simmons RK, Howard JL, Simpson DN, Akil H, Clinton SM. DNA methylation in the developing hippocampus and amygdala of anxiety-prone versus risk-taking rats. Developmental Neuroscience. 34: 58-67. PMID 22572572 DOI: 10.1159/000336641  1
2012 Sequeira A, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li J, Schatzberg AF, Watson SJ, Akil H, Myers RM, Jones EG, Bunney WE, Vawter MP. Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide. Plos One. 7: e35367. PMID 22558144 DOI: 10.1371/journal.pone.0035367  1
2012 García-Fuster MJ, Parks GS, Clinton SM, Watson SJ, Akil H, Civelli O. The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 22: 607-13. PMID 22209364 DOI: 10.1016/j.euroneuro.2011.12.001  1
2012 Capriles N, Watson S, Akil H. Individual differences in the improvement of cocaine-induced place preference response by the 5-HT2C receptor antagonist SB242084 in rats. Psychopharmacology. 220: 731-40. PMID 21989806 DOI: 10.1007/s00213-011-2524-9  1
2012 Wei Q, Fentress HM, Hoversten MT, Zhang L, Hebda-Bauer EK, Watson SJ, Seasholtz AF, Akil H. Early-life forebrain glucocorticoid receptor overexpression increases anxiety behavior and cocaine sensitization. Biological Psychiatry. 71: 224-31. PMID 21872848 DOI: 10.1016/j.biopsych.2011.07.009  1
2012 Kerman IA, Clinton SM, Simpson DN, Bedrosian TA, Bernard R, Akil H, Watson SJ. Inborn differences in environmental reactivity predict divergent diurnal behavioral, endocrine, and gene expression rhythms. Psychoneuroendocrinology. 37: 256-69. PMID 21775066 DOI: 10.1016/j.psyneuen.2011.06.010  1
2011 Clinton SM, Kerman IA, Orr HR, Bedrosian TA, Abraham AD, Simpson DN, Watson SJ, Akil H. Pattern of forebrain activation in high novelty-seeking rats following aggressive encounter. Brain Research. 1422: 20-31. PMID 21974861 DOI: 10.1016/j.brainres.2011.08.033  1
2011 Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE. A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience. 196: 80-96. PMID 21945724 DOI: 10.1016/j.neuroscience.2011.09.004  1
2011 Kerman IA, Clinton SM, Bedrosian TA, Abraham AD, Rosenthal DT, Akil H, Watson SJ. High novelty-seeking predicts aggression and gene expression differences within defined serotonergic cell groups. Brain Research. 1419: 34-45. PMID 21925645 DOI: 10.1016/j.brainres.2011.08.038  1
2011 McEwen BS, Akil H. Introduction to social neuroscience: gene, environment, brain, body. Annals of the New York Academy of Sciences. 1231: vii-ix. PMID 21884157 DOI: 10.1111/j.1749-6632.2011.06154.x  1
2011 Clinton SM, Stead JD, Miller S, Watson SJ, Akil H. Developmental underpinnings of differences in rodent novelty-seeking and emotional reactivity. The European Journal of Neuroscience. 34: 994-1005. PMID 21864320 DOI: 10.1111/j.1460-9568.2011.07811.x  1
2011 García-Fuster MJ, Flagel SB, Mahmood ST, Mayo LM, Thompson RC, Watson SJ, Akil H. Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2303-17. PMID 21796105 DOI: 10.1038/npp.2011.119  1
2011 Moon E, Rollins B, Mesén A, Sequeira A, Myers RM, Akil H, Watson SJ, Barchas J, Jones EG, Schatzberg A, Bunney WE, DeLisi LE, Byerley W, Vawter MP. Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. Schizophrenia Research. 131: 52-7. PMID 21745728 DOI: 10.1016/j.schres.2011.06.024  1
2011 Turner CA, Clinton SM, Thompson RC, Watson SJ, Akil H. Fibroblast growth factor-2 (FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals. Proceedings of the National Academy of Sciences of the United States of America. 108: 8021-5. PMID 21518861 DOI: 10.1073/pnas.1103732108  1
2011 Calvo N, Cecchi M, Kabbaj M, Watson SJ, Akil H. Differential effects of social defeat in rats with high and low locomotor response to novelty. Neuroscience. 183: 81-9. PMID 21453756 DOI: 10.1016/j.neuroscience.2011.03.046  1
2011 Cummings JA, Gowl BA, Westenbroek C, Clinton SM, Akil H, Becker JB. Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats. Biology of Sex Differences. 2: 3. PMID 21396095 DOI: 10.1186/2042-6410-2-3  1
2011 Akil H, Martone ME, Van Essen DC. Challenges and opportunities in mining neuroscience data. Science (New York, N.Y.). 331: 708-12. PMID 21311009 DOI: 10.1126/science.1199305  1
2011 Stedenfeld KA, Clinton SM, Kerman IA, Akil H, Watson SJ, Sved AF. Novelty-seeking behavior predicts vulnerability in a rodent model of depression. Physiology & Behavior. 103: 210-6. PMID 21303678 DOI: 10.1016/j.physbeh.2011.02.001  1
2011 Eren-Koçak E, Turner CA, Watson SJ, Akil H. Short-hairpin RNA silencing of endogenous fibroblast growth factor 2 in rat hippocampus increases anxiety behavior. Biological Psychiatry. 69: 534-40. PMID 21215386 DOI: 10.1016/j.biopsych.2010.11.020  1
2011 Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H. A selective role for dopamine in stimulus-reward learning. Nature. 469: 53-7. PMID 21150898 DOI: 10.1038/nature09588  1
2011 Burghardt PR, Flagel SB, Burghardt KJ, Britton SL, Gerard-Koch L, Watson SJ, Akil H. Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 390-401. PMID 20927049 DOI: 10.1038/npp.2010.144  1
2011 Bernard R, Kerman IA, Thompson RC, Jones EG, Bunney WE, Barchas JD, Schatzberg AF, Myers RM, Akil H, Watson SJ. Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. Molecular Psychiatry. 16: 634-46. PMID 20386568 DOI: 10.1038/mp.2010.44  1
2010 Krolewski DM, Medina A, Kerman IA, Bernard R, Burke S, Thompson RC, Bunney WE, Schatzberg AF, Myers RM, Akil H, Jones EG, Watson SJ. Expression patterns of corticotropin-releasing factor, arginine vasopressin, histidine decarboxylase, melanin-concentrating hormone, and orexin genes in the human hypothalamus. The Journal of Comparative Neurology. 518: 4591-611. PMID 20886624 DOI: 10.1002/cne.22480  1
2010 Hebda-Bauer EK, Pletsch A, Darwish H, Fentress H, Simmons TA, Wei Q, Watson SJ, Akil H. Forebrain glucocorticoid receptor overexpression increases environmental reactivity and produces a stress-induced spatial discrimination deficit. Neuroscience. 169: 645-53. PMID 20562006 DOI: 10.1016/j.neuroscience.2010.05.033  1
2010 Novak CM, Escande C, Burghardt PR, Zhang M, Barbosa MT, Chini EN, Britton SL, Koch LG, Akil H, Levine JA. Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Hormones and Behavior. 58: 355-67. PMID 20350549 DOI: 10.1016/j.yhbeh.2010.03.013  1
2010 Akil H, Brenner S, Kandel E, Kendler KS, King MC, Scolnick E, Watson JD, Zoghbi HY. Medicine. The future of psychiatric research: genomes and neural circuits. Science (New York, N.Y.). 327: 1580-1. PMID 20339051 DOI: 10.1126/science.1188654  1
2010 Clinton SM, Bedrosian TA, Abraham AD, Watson SJ, Akil H. Neural and environmental factors impacting maternal behavior differences in high- versus low-novelty-seeking rats. Hormones and Behavior. 57: 463-73. PMID 20156440 DOI: 10.1016/j.yhbeh.2010.02.004  1
2010 García-Fuster MJ, Perez JA, Clinton SM, Watson SJ, Akil H. Impact of cocaine on adult hippocampal neurogenesis in an animal model of differential propensity to drug abuse. The European Journal of Neuroscience. 31: 79-89. PMID 20104651 DOI: 10.1111/j.1460-9568.2009.07045.x  1
2010 Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H. An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 388-400. PMID 19794408 DOI: 10.1038/npp.2009.142  1
2010 Kollack-Walker S, Day HEW, Akil H. Central Stress Neurocircuits Encyclopedia of Stress. 424-432. DOI: 10.1016/B978-012373947-6.00073-8  1
2009 Akil H, Watson SJ, Dalack GW, Greden JF, Zubieta JK. In memory of Elizabeth Young. Biological Psychiatry. 66: e25-6. PMID 19900609 DOI: 10.1016/j.biopsych.2009.09.018  1
2009 Martin MV, Rollins B, Sequeira PA, Mesén A, Byerley W, Stein R, Moon EA, Akil H, Jones EG, Watson SJ, Barchas J, DeLisi LE, Myers RM, Schatzberg A, Bunney WE, et al. Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation. Bmc Medical Genomics. 2: 62. PMID 19772658 DOI: 10.1186/1755-8794-2-62  1
2009 Evans SJ, Akil H, Watson SJ. Analyzing gene expression in depression. The American Journal of Psychiatry. 166: 961-3. PMID 19723790 DOI: 10.1176/appi.ajp.2009.09060806  1
2009 Perez JA, Clinton SM, Turner CA, Watson SJ, Akil H. A new role for FGF2 as an endogenous inhibitor of anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6379-87. PMID 19439615 DOI: 10.1523/JNEUROSCI.4829-08.2009  1
2009 Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, ... ... Akil H, et al. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proceedings of the National Academy of Sciences of the United States of America. 106: 7501-6. PMID 19416921 DOI: 10.1073/pnas.0813386106  1
2009 Rollins B, Martin MV, Sequeira PA, Moon EA, Morgan LZ, Watson SJ, Schatzberg A, Akil H, Myers RM, Jones EG, Wallace DC, Bunney WE, Vawter MP. Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. Plos One. 4: e4913. PMID 19290059 DOI: 10.1371/journal.pone.0004913  1
2009 Bernard R, Kerman IA, Meng F, Evans SJ, Amrein I, Jones EG, Bunney WE, Akil H, Watson SJ, Thompson RC. Gene expression profiling of neurochemically defined regions of the human brain by in situ hybridization-guided laser capture microdissection. Journal of Neuroscience Methods. 178: 46-54. PMID 19070632 DOI: 10.1016/j.jneumeth.2008.11.012  1
2009 Turner CA, Capriles N, Flagel SB, Perez JA, Clinton SM, Watson SJ, Akil H. Neonatal FGF2 alters cocaine self-administration in the adult rat. Pharmacology, Biochemistry, and Behavior. 92: 100-4. PMID 19014962 DOI: 10.1016/j.pbb.2008.10.018  1
2009 Wright SL, Langenecker SA, Deldin PJ, Rapport LJ, Nielson KA, Kade AM, Own LS, Akil H, Young EA, Zubieta JK. Gender-specific disruptions in emotion processing in younger adults with depression. Depression and Anxiety. 26: 182-9. PMID 18800371 DOI: 10.1002/da.20502  1
2009 Flagel SB, Akil H, Robinson TE. Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction. Neuropharmacology. 56: 139-48. PMID 18619474 DOI: 10.1016/j.neuropharm.2008.06.027  1
2009 García-Fuster MJ, Clinton SM, Watson SJ, Akil H. Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1123-34. PMID 18580876 DOI: 10.1038/npp.2008.88  1
2008 Gardner D, Akil H, Ascoli GA, Bowden DM, Bug W, Donohue DE, Goldberg DH, Grafstein B, Grethe JS, Gupta A, Halavi M, Kennedy DN, Marenco L, Martone ME, Miller PL, et al. The neuroscience information framework: a data and knowledge environment for neuroscience. Neuroinformatics. 6: 149-60. PMID 18946742 DOI: 10.1007/s12021-008-9024-z  1
2008 Turner CA, Flagel SB, Clinton SM, Akil H, Watson SJ. Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat. Neuroscience Letters. 446: 105-7. PMID 18824081 DOI: 10.1016/j.neulet.2008.09.037  1
2008 Cecchi M, Capriles N, Watson SJ, Akil H. Differential responses to morphine-induced analgesia in the tail-flick test. Behavioural Brain Research. 194: 146-51. PMID 18656501 DOI: 10.1016/j.bbr.2008.06.034  1
2008 Turner CA, Gula EL, Taylor LP, Watson SJ, Akil H. Antidepressant-like effects of intracerebroventricular FGF2 in rats. Brain Research. 1224: 63-8. PMID 18586016 DOI: 10.1016/j.brainres.2008.05.088  1
2008 Day HE, Kryskow EM, Watson SJ, Akil H, Campeau S. Regulation of hippocampal alpha1d adrenergic receptor mRNA by corticosterone in adrenalectomized rats. Brain Research. 1218: 132-40. PMID 18534559 DOI: 10.1016/j.brainres.2008.04.067  1
2008 Akil H, Evans SJ, Turner CA, Perez J, Myers RM, Bunney WE, Jones EG, Watson SJ. The fibroblast growth factor family and mood disorders. Novartis Foundation Symposium. 289: 94-6; discussion 97-. PMID 18497097  1
2008 Davis BA, Clinton SM, Akil H, Becker JB. The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred High-Responder and Low-Responder rats. Pharmacology, Biochemistry, and Behavior. 90: 331-8. PMID 18445506 DOI: 10.1016/j.pbb.2008.03.008  1
2008 Jama A, Cecchi M, Calvo N, Watson SJ, Akil H. Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test. Psychopharmacology. 198: 333-40. PMID 18438645 DOI: 10.1007/s00213-008-1126-7  1
2008 Shao L, Martin MV, Watson SJ, Schatzberg A, Akil H, Myers RM, Jones EG, Bunney WE, Vawter MP. Mitochondrial involvement in psychiatric disorders. Annals of Medicine. 40: 281-95. PMID 18428021 DOI: 10.1080/07853890801923753  1
2008 Ballaz SJ, Akil H, Watson SJ. The CCK-system underpins novelty-seeking behavior in the rat: gene expression and pharmacological analyses. Neuropeptides. 42: 245-53. PMID 18410964 DOI: 10.1016/j.npep.2008.03.001  1
2008 Sequeira A, Meng F, Rollins B, Myers RM, Jones EG, Watson SJ, Akil H, Schatzberg AF, Barchas J, Bunney WE, Vawter MP. Coding SNPs included in exon arrays for the study of psychiatric disorders. Molecular Psychiatry. 13: 363-5. PMID 18347597 DOI: 10.1038/sj.mp.4002123  1
2008 Briand LA, Flagel SB, Garcia-Fuster MJ, Watson SJ, Akil H, Sarter M, Robinson TE. Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2969-80. PMID 18305460 DOI: 10.1038/npp.2008.18  1
2008 Clinton S, Miller S, Watson SJ, Akil H. Prenatal stress does not alter innate novelty-seeking behavioral traits, but differentially affects individual differences in neuroendocrine stress responsivity. Psychoneuroendocrinology. 33: 162-77. PMID 18077099 DOI: 10.1016/j.psyneuen.2007.10.012  1
2008 Turner CA, Calvo N, Frost DO, Akil H, Watson SJ. The fibroblast growth factor system is downregulated following social defeat. Neuroscience Letters. 430: 147-50. PMID 18061349 DOI: 10.1016/j.neulet.2007.10.041  1
2008 Flagel SB, Watson SJ, Akil H, Robinson TE. Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behavioural Brain Research. 186: 48-56. PMID 17719099 DOI: 10.1016/j.bbr.2007.07.022  1
2008 McKinney BC, Schneider JS, Schafer GL, Lowing JL, Mohan S, Zhao MX, Heng MY, Albin RL, Seasholtz AF, Akil H, Murphy GG. Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter. Genes, Brain, and Behavior. 7: 203-13. PMID 17640289 DOI: 10.1111/j.1601-183X.2007.00339.x  1
2008 Chao M, Flint J, Talmage DA, Bothwell M, Buonanno A, Lu B, Akil H, Malaspina D, Raff MC, Castrén E, Javitt DC, Owen MJ, Giedd JN, Sklar P. General discussion I Novartis Foundation Symposium. 289: 87-93.  1
2008 McAllister K, Castrén E, Lu B, Giedd JN, Barde YA, Sendtner M, Chao M, Raff MC, Spedding M, Lee FS, Akil H, Bothwell M, Flint J, Tongiorgi E, Walsh F, et al. Discussion Novartis Foundation Symposium. 289: 53-59.  1
2008 Bothwell M, Akil H, Hen R, Spedding M, Sendtner M, Tongiorgi E, Chao M, Malaspina D, Raff MC, Castrén E. Discussion Novartis Foundation Symposium. 289: 233-237.  1
2008 Chao M, Flint J, Giedd JN, Malaspina D, Hen R, Spedding M, Owen MJ, Sklar P, Akil H, Buonanno A. General discussion II Novartis Foundation Symposium. 289: 193-195.  1
2008 McAllister K, Castrén E, Lu B, Giedd JN, Barde YA, Sendtner M, Chao M, Raff MC, Spedding M, Lee FS, Akil H, Bothwell M, Flint J, Tongiorgi E, Walsh F, et al. Discussion Novartis Foundation Symposium. 289: 53-59.  1
2008 McAllister K, Castrén E, Lu B, Giedd JN, Barde YA, Sendtner M, Chao M, Raff MC, Spedding M, Lee FS, Akil H, Bothwell M, Flint J, Tongiorgi E, Walsh F, et al. Discussion Novartis Foundation Symposium. 289: 53-59.  1
2008 McAllister K, Castrén E, Lu B, Giedd JN, Barde YA, Sendtner M, Chao M, Raff MC, Spedding M, Lee FS, Akil H, Bothwell M, Flint J, Tongiorgi E, Walsh F, et al. Discussion Novartis Foundation Symposium. 289: 53-59.  1
2007 Hebda-Bauer EK, Luo J, Watson SJ, Akil H. Female CREBalphadelta- deficient mice show earlier age-related cognitive deficits than males. Neuroscience. 150: 260-72. PMID 18029102 DOI: 10.1016/j.neuroscience.2007.09.019  1
2007 Ballaz SJ, Akil H, Watson SJ. The CCK-system mediates adaptation to novelty-induced stress in the rat: a pharmacological evidence. Neuroscience Letters. 428: 27-32. PMID 17950531 DOI: 10.1016/j.neulet.2007.09.035  1
2007 Kerman IA, Bernard R, Rosenthal D, Beals J, Akil H, Watson SJ. Distinct populations of presympathetic-premotor neurons express orexin or melanin-concentrating hormone in the rat lateral hypothalamus. The Journal of Comparative Neurology. 505: 586-601. PMID 17924541 DOI: 10.1002/cne.21511  1
2007 Ballaz SJ, Akil H, Watson SJ. Previous experience affects subsequent anxiety-like responses in rats bred for novelty seeking. Behavioral Neuroscience. 121: 1113-8. PMID 17907843 DOI: 10.1037/0735-7044.121.5.1113  1
2007 Karssen AM, Her S, Li JZ, Patel PD, Meng F, Bunney WE, Jones EG, Watson SJ, Akil H, Myers RM, Schatzberg AF, Lyons DM. Stress-induced changes in primate prefrontal profiles of gene expression. Molecular Psychiatry. 12: 1089-102. PMID 17893703 DOI: 10.1038/sj.mp.4002095  1
2007 Li JZ, Meng F, Tsavaler L, Evans SJ, Choudary PV, Tomita H, Vawter MP, Walsh D, Shokoohi V, Chung T, Bunney WE, Jones EG, Akil H, Watson SJ, Myers RM. Sample matching by inferred agonal stress in gene expression analyses of the brain. Bmc Genomics. 8: 336. PMID 17892578 DOI: 10.1186/1471-2164-8-336  1
2007 Ballaz SJ, Akil H, Watson SJ. The 5-HT7 receptor: role in novel object discrimination and relation to novelty-seeking behavior. Neuroscience. 149: 192-202. PMID 17869441 DOI: 10.1016/j.neuroscience.2007.07.043  1
2007 Langenecker SA, Zubieta JK, Young EA, Akil H, Nielson KA. A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go Test. Journal of Clinical and Experimental Neuropsychology. 29: 842-53. PMID 17852593 DOI: 10.1080/13803390601147611  1
2007 Wei Q, Hebda-Bauer EK, Pletsch A, Luo J, Hoversten MT, Osetek AJ, Evans SJ, Watson SJ, Seasholtz AF, Akil H. Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8836-44. PMID 17699665 DOI: 10.1523/JNEUROSCI.0910-07.2007  1
2007 Langenecker SA, Kennedy SE, Guidotti LM, Briceno EM, Own LS, Hooven T, Young EA, Akil H, Noll DC, Zubieta JK. Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder. Biological Psychiatry. 62: 1272-80. PMID 17585888 DOI: 10.1016/j.biopsych.2007.02.019  1
2007 Ballaz SJ, Akil H, Watson SJ. Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior. Neuroscience. 147: 428-38. PMID 17543469 DOI: 10.1016/j.neuroscience.2007.04.024  1
2007 Atz M, Walsh D, Cartagena P, Li J, Evans S, Choudary P, Overman K, Stein R, Tomita H, Potkin S, Myers R, Watson SJ, Jones EG, Akil H, Bunney WE, et al. Methodological considerations for gene expression profiling of human brain. Journal of Neuroscience Methods. 163: 295-309. PMID 17512057 DOI: 10.1016/j.jneumeth.2007.03.022  1
2007 Buck BJ, Kerman IA, Burghardt PR, Koch LG, Britton SL, Akil H, Watson SJ. Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome. Neuroscience Letters. 419: 178-83. PMID 17490814 DOI: 10.1016/j.neulet.2007.04.042  1
2007 Clinton SM, Vázquez DM, Kabbaj M, Kabbaj MH, Watson SJ, Akil H. Individual differences in novelty-seeking and emotional reactivity correlate with variation in maternal behavior. Hormones and Behavior. 51: 655-64. PMID 17462647 DOI: 10.1016/j.yhbeh.2007.03.009  1
2007 Rozeboom AM, Akil H, Seasholtz AF. Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 4688-93. PMID 17360585 DOI: 10.1073/pnas.0606067104  1
2007 Flagel SB, Watson SJ, Robinson TE, Akil H. Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of rats. Psychopharmacology. 191: 599-607. PMID 16972103 DOI: 10.1007/s00213-006-0535-8  1
2007 Cecchi M, Capriles N, Watson SJ, Akil H. Beta1 adrenergic receptors in the bed nucleus of stria terminalis mediate differential responses to opiate withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 589-99. PMID 16823388 DOI: 10.1038/sj.npp.1301140  1
2007 Sliwerska E, Meng F, Speed TP, Jones EG, Bunney WE, Akil H, Watson SJ, Burmeister M. SNPs on chips: the hidden genetic code in expression arrays. Biological Psychiatry. 61: 13-6. PMID 16690034 DOI: 10.1016/j.biopsych.2006.01.023  1
2006 Kerman IA, Shabrang C, Taylor L, Akil H, Watson SJ. Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem. The Journal of Comparative Neurology. 499: 882-96. PMID 17072838 DOI: 10.1002/cne.21129  1
2006 Vawter MP, Tomita H, Meng F, Bolstad B, Li J, Evans S, Choudary P, Atz M, Shao L, Neal C, Walsh DM, Burmeister M, Speed T, Myers R, Jones EG, ... ... Akil H, et al. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders. Molecular Psychiatry. 11: 615, 663-79. PMID 16636682 DOI: 10.1038/sj.mp.4001830  1
2006 Turner CA, Akil H, Watson SJ, Evans SJ. The fibroblast growth factor system and mood disorders. Biological Psychiatry. 59: 1128-35. PMID 16631131 DOI: 10.1016/j.biopsych.2006.02.026  1
2006 Kerman IA, Akil H, Watson SJ. Rostral elements of sympatho-motor circuitry: a virally mediated transsynaptic tracing study. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3423-33. PMID 16571749 DOI: 10.1523/JNEUROSCI.5283-05.2006  1
2006 Stead JD, Clinton S, Neal C, Schneider J, Jama A, Miller S, Vazquez DM, Watson SJ, Akil H. Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors. Behavior Genetics. 36: 697-712. PMID 16502134 DOI: 10.1007/s10519-006-9058-7  1
2006 Karssen AM, Li JZ, Her S, Patel PD, Meng F, Evans SJ, Vawter MP, Tomita H, Choudary PV, Bunney WE, Jones EG, Watson SJ, Akil H, Myers RM, Schatzberg AF, et al. Application of microarray technology in primate behavioral neuroscience research. Methods (San Diego, Calif.). 38: 227-34. PMID 16469505 DOI: 10.1016/j.ymeth.2005.09.017  1
2006 Stead JD, Neal C, Meng F, Wang Y, Evans S, Vazquez DM, Watson SJ, Akil H. Transcriptional profiling of the developing rat brain reveals that the most dramatic regional differentiation in gene expression occurs postpartum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 345-53. PMID 16399705 DOI: 10.1523/JNEUROSCI.2755-05.2006  1
2006 Kerman IA, Buck BJ, Evans SJ, Akil H, Watson SJ. Combining laser capture microdissection with quantitative real-time PCR: effects of tissue manipulation on RNA quality and gene expression. Journal of Neuroscience Methods. 153: 71-85. PMID 16337273 DOI: 10.1016/j.jneumeth.2005.10.010  1
2005 Dai M, Wang P, Boyd AD, Kostov G, Athey B, Jones EG, Bunney WE, Myers RM, Speed TP, Akil H, Watson SJ, Meng F. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Research. 33: e175. PMID 16284200 DOI: 10.1093/nar/gni179  1
2005 Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE, Akil H, Watson SJ, Jones EG. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proceedings of the National Academy of Sciences of the United States of America. 102: 15653-8. PMID 16230605 DOI: 10.1073/pnas.0507901102  1
2005 Hebda-Bauer EK, Watson SJ, Akil H. Cognitive performance is highly sensitive to prior experience in mice with a learning and memory deficit: failure leads to more failure. Learning & Memory (Cold Spring Harbor, N.Y.). 12: 461-71. PMID 16166394 DOI: 10.1101/lm.94105  1
2005 Helmreich DL, Parfitt DB, Lu XY, Akil H, Watson SJ. Relation between the hypothalamic-pituitary-thyroid (HPT) axis and the hypothalamic-pituitary-adrenal (HPA) axis during repeated stress. Neuroendocrinology. 81: 183-92. PMID 16020927 DOI: 10.1159/000087001  1
2005 Shieh KR, Yang SC, Lu XY, Akil H, Watson SJ. Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. Journal of Biomedical Science. 12: 209-17. PMID 15864751 DOI: 10.1007/s11373-004-8176-6  1
2004 Evans SJ, Choudary PV, Neal CR, Li JZ, Vawter MP, Tomita H, Lopez JF, Thompson RC, Meng F, Stead JD, Walsh DM, Myers RM, Bunney WE, Watson SJ, Jones EG, ... Akil H, et al. Dysregulation of the fibroblast growth factor system in major depression. Proceedings of the National Academy of Sciences of the United States of America. 101: 15506-11. PMID 15483108 DOI: 10.1073/pnas.0406788101  1
2004 Kabbaj M, Evans S, Watson SJ, Akil H. The search for the neurobiological basis of vulnerability to drug abuse: using microarrays to investigate the role of stress and individual differences. Neuropharmacology. 47: 111-22. PMID 15464130 DOI: 10.1016/j.neuropharm.2004.07.021  1
2004 Isgor C, Kabbaj M, Akil H, Watson SJ. Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats. Hippocampus. 14: 636-48. PMID 15301440 DOI: 10.1002/hipo.10207  1
2004 Wei Q, Lu XY, Liu L, Schafer G, Shieh KR, Burke S, Robinson TE, Watson SJ, Seasholtz AF, Akil H. Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proceedings of the National Academy of Sciences of the United States of America. 101: 11851-6. PMID 15280545 DOI: 10.1073/pnas.0402208101  1
2004 Hebda-Bauer EK, Watson SJ, Akil H. CREB deficient mice show inhibition and low activity in novel environments without changes in stress reactivity. The European Journal of Neuroscience. 20: 503-13. PMID 15233759 DOI: 10.1111/j.1460-9568.2004.03487.x  1
2004 Tomita H, Vawter MP, Walsh DM, Evans SJ, Choudary PV, Li J, Overman KM, Atz ME, Myers RM, Jones EG, Watson SJ, Akil H, Bunney WE. Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biological Psychiatry. 55: 346-52. PMID 14960286 DOI: 10.1016/j.biopsych.2003.10.013  1
2004 Erb S, Funk D, Borkowski S, Watson SJ, Akil H. Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis. Neuroscience. 123: 1003-9. PMID 14751291 DOI: 10.1016/j.neuroscience.2003.10.031  1
2004 López-Figueroa AL, Norton CS, López-Figueroa MO, Armellini-Dodel D, Burke S, Akil H, López JF, Watson SJ. Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biological Psychiatry. 55: 225-33. PMID 14744462  1
2004 Li JZ, Vawter MP, Walsh DM, Tomita H, Evans SJ, Choudary PV, Lopez JF, Avelar A, Shokoohi V, Chung T, Mesarwi O, Jones EG, Watson SJ, Akil H, Bunney WE, et al. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Human Molecular Genetics. 13: 609-16. PMID 14734628 DOI: 10.1093/hmg/ddh065  1
2004 Vawter MP, Evans S, Choudary P, Tomita H, Meador-Woodruff J, Molnar M, Li J, Lopez JF, Myers R, Cox D, Watson SJ, Akil H, Jones EG, Bunney WE. Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 373-84. PMID 14583743 DOI: 10.1038/sj.npp.1300337  1
2003 Evans SJ, Watson SJ, Akil H. Evaluation of sensitivity, performance and reproducibility of microarray technology in neuronal tissue. Integrative and Comparative Biology. 43: 780-5. PMID 21680476 DOI: 10.1093/icb/43.6.780  1
2003 Isgor C, Cecchi M, Kabbaj M, Akil H, Watson SJ. Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone. Neuroscience. 121: 837-45. PMID 14580933 DOI: 10.1016/S0306-4522(03)00561-X  1
2003 Evans SJ, Choudary PV, Vawter MP, Li J, Meador-Woodruff JH, Lopez JF, Burke SM, Thompson RC, Myers RM, Jones EG, Bunney WE, Watson SJ, Akil H. DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles. Neurobiology of Disease. 14: 240-50. PMID 14572446 DOI: 10.1016/S0969-9961(03)00126-8  1
2003 McNally GP, Akil H. Selective down-regulation of hippocampal glucocorticoid receptors during opiate withdrawal. Brain Research. Molecular Brain Research. 118: 152-5. PMID 14559365 DOI: 10.1016/S0169-328X(03)00333-4  1
2003 Morgan C, Thompson RC, Watson SJ, Akil H. Syrian hamster proopiomelanocortin cDNA cloning and early seasonal changes in testicular expression. General and Comparative Endocrinology. 133: 353-7. PMID 12957479  1
2003 Lu XY, Barsh GS, Akil H, Watson SJ. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7863-72. PMID 12944516  1
2003 Ostrander MM, Badiani A, Day HE, Norton CS, Watson SJ, Akil H, Robinson TE. Environmental context and drug history modulate amphetamine-induced c-fos mRNA expression in the basal ganglia, central extended amygdala, and associated limbic forebrain. Neuroscience. 120: 551-71. PMID 12890524 DOI: 10.1016/S0306-4522(03)00247-1  1
2003 Morgan C, Urbanski HF, Fan W, Akil H, Cone RD. Pheromone-induced anorexia in male Syrian hamsters. American Journal of Physiology. Endocrinology and Metabolism. 285: E1028-38. PMID 12888484 DOI: 10.1152/ajpendo.00010.2003  1
2003 Neal CR, Owens CE, Taylor LP, Hoversten MT, Akil H, Watson SJ. Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors. Journal of Chemical Neuroanatomy. 25: 233-47. PMID 12842269 DOI: 10.1016/S0891-0618(03)00032-2  1
2003 Ferguson SM, Norton CS, Watson SJ, Akil H, Robinson TE. Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context. Journal of Neurochemistry. 86: 33-44. PMID 12807422 DOI: 10.1046/j.1471-4159.2003.01815.x  1
2003 Isgor C, Shieh KR, Akil H, Watson SJ. Colocalization of estrogen beta-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei. Anatomy and Embryology. 206: 461-9. PMID 12690447 DOI: 10.1007/s00429-003-0314-9  1
2003 Gordon NS, Burke S, Akil H, Watson SJ, Panksepp J. Socially-induced brain 'fertilization': play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats. Neuroscience Letters. 341: 17-20. PMID 12676333 DOI: 10.1016/S0304-3940(03)00158-7  1
2003 Bunney WE, Bunney BG, Vawter MP, Tomita H, Li J, Evans SJ, Choudary PV, Myers RM, Jones EG, Watson SJ, Akil H. Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. The American Journal of Psychiatry. 160: 657-66. PMID 12668351 DOI: 10.1176/appi.ajp.160.4.657  1
2003 Uslaner JM, Norton CS, Watson SJ, Akil H, Robinson TE. Amphetamine-induced c-fos mRNA expression in the caudate-putamen and subthalamic nucleus: interactions between dose, environment, and neuronal phenotype. Journal of Neurochemistry. 85: 105-14. PMID 12641732  1
2003 Devine DP, Hoversten MT, Ueda Y, Akil H. Nociceptin/orphanin FQ content is decreased in forebrain neurones during acute stress. Journal of Neuroendocrinology. 15: 69-74. PMID 12535171 DOI: 10.1046/j.1365-2826.2003.00868.x  1
2003 Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. Mineralocorticoid receptor function in major depression. Archives of General Psychiatry. 60: 24-8. PMID 12511169  1
2002 Nicholson JR, Akil H, Watson SJ. Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors. Neuroscience. 115: 637-43. PMID 12421628  1
2002 Isgor C, Huang GC, Akil H, Watson SJ. Correlation of estrogen beta-receptor messenger RNA with endogenous levels of plasma estradiol and progesterone in the female rat hypothalamus, the bed nucleus of stria terminalis and the medial amygdala. Brain Research. Molecular Brain Research. 106: 30-41. PMID 12393262  1
2002 Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ. Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake. Endocrinology. 143: 3905-15. PMID 12239102 DOI: 10.1210/en.2002-220150  1
2002 Evans SJ, Datson NA, Kabbaj M, Thompson RC, Vreugdenhil E, De Kloet ER, Watson SJ, Akil H. Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis. Serial Analysis of Gene Expression. The European Journal of Neuroscience. 16: 409-13. PMID 12193183 DOI: 10.1046/j.1460-9568.2002.02097.x  1
2002 Campeau S, Dolan D, Akil H, Watson SJ. c-fos mRNA induction in acute and chronic audiogenic stress: possible role of the orbitofrontal cortex in habituation. Stress (Amsterdam, Netherlands). 5: 121-30. PMID 12186690 DOI: 10.1080/10253890290027895  1
2002 Kabbaj M, Isgor C, Watson SJ, Akil H. Stress during adolescence alters behavioral sensitization to amphetamine. Neuroscience. 113: 395-400. PMID 12127096 DOI: 10.1016/S0306-4522(02)00188-4  1
2002 Day HE, Vittoz NM, Oates MM, Badiani A, Watson SJ, Robinson TE, Akil H. A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis. Brain Research. 945: 151-9. PMID 12126877 DOI: 10.1016/S0006-8993(02)02747-6  1
2002 López-Figueroa MO, Caamaño CA, Morano MI, Akil H, Watson SJ. Fluorescent imaging of mitochondrial nitric oxide in living cells. Methods in Enzymology. 352: 296-303. PMID 12125355  1
2002 McNally GP, Akil H. Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal. Neuroscience. 112: 605-17. PMID 12074902 DOI: 10.1016/S0306-4522(02)00105-7  1
2002 Gordon NS, Kollack-Walker S, Akil H, Panksepp J. Expression of c-fos gene activation during rough and tumble play in juvenile rats. Brain Research Bulletin. 57: 651-9. PMID 11927369 DOI: 10.1016/S0361-9230(01)00762-6  1
2002 Norton CS, Neal CR, Kumar S, Akil H, Watson SJ. Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems. The Journal of Comparative Neurology. 444: 358-68. PMID 11891648 DOI: 10.1002/cne.10154  1
2002 Klebaur JE, Ostrander MM, Norton CS, Watson SJ, Akil H, Robinson TE. The ability of amphetamine to evoke arc (Arg 3.1) mRNA expression in the caudate, nucleus accumbens and neocortex is modulated by environmental context. Brain Research. 930: 30-6. PMID 11879792 DOI: 10.1016/S0006-8993(01)03400-X  1
2002 Owens CE, Akil H. Determinants of ligand selectivity at the kappa-receptor based on the structure of the orphanin FQ receptor. The Journal of Pharmacology and Experimental Therapeutics. 300: 992-9. PMID 11861808  0.36
2001 Caamaño CA, Morano MI, Akil H. Corticosteroid receptors: a dynamic interplay between protein folding and homeostatic control. Possible implications in psychiatric disorders. Psychopharmacology Bulletin. 35: 6-23. PMID 12397867  0.88
2001 Kabbaj M, Norton CS, Kollack-Walker S, Watson SJ, Robinson TE, Akil H. Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior. Psychopharmacology. 158: 382-7. PMID 11797059 DOI: 10.1007/s002130100918  1
2001 Neal CR, Akil H, Watson SJ. Expression of orphanin FQ and the opioid receptor-like (ORL1) receptor in the developing human and rat brain. Journal of Chemical Neuroanatomy. 22: 219-49. PMID 11719021 DOI: 10.1016/S0891-0618(01)00135-1  1
2001 Uslaner J, Badiani A, Day HE, Watson SJ, Akil H, Robinson TE. Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens. Brain Research. 920: 106-16. PMID 11716816 DOI: 10.1016/S0006-8993(01)03040-2  1
2001 Kabbaj M, Akil H. Individual differences in novelty-seeking behavior in rats: a c-fos study. Neuroscience. 106: 535-45. PMID 11591454 DOI: 10.1016/S0306-4522(01)00291-3  1
2001 López-Figueroa MO, Caamaño C, Marin R, Guerra B, Alonso R, Morano MI, Akil H, Watson SJ. Characterization of basal nitric oxide production in living cells. Biochimica Et Biophysica Acta. 1540: 253-64. PMID 11583820  1
2001 McNally GP, Akil H. Effects of contextual or olfactory cues previously paired with morphine withdrawal on behavior and pain sensitivity in the rat. Psychopharmacology. 156: 381-7. PMID 11498714 DOI: 10.1007/s002130100743  1
2001 Uslaner J, Badiani A, Norton CS, Day HE, Watson SJ, Akil H, Robinson TE. Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context. The European Journal of Neuroscience. 13: 1977-83. PMID 11403691 DOI: 10.1046/j.0953-816X.2001.01574.x  1
2001 Lu XY, Nicholson JR, Akil H, Watson SJ. Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132). Neuroreport. 12: 1281-4. PMID 11338207  1
2001 Helmreich DL, Itoi K, Lopez-Figueroa MO, Akil H, Watson SJ. Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus: differential regulation by corticosterone. Brain Research. Molecular Brain Research. 88: 62-73. PMID 11295232  1
2001 Danielson PB, Hoversten MT, Fitzpatrick M, Schreck C, Akil H, Dores RM. Sturgeon orphanin, a molecular "fossil" that bridges the gap between the opioids and orphanin FQ/nociceptin. The Journal of Biological Chemistry. 276: 22114-9. PMID 11290742 DOI: 10.1074/jbc.M011741200  1
2001 Devine DP, Watson SJ, Akil H. Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis. Neuroscience. 102: 541-53. PMID 11226692 DOI: 10.1016/S0306-4522(00)00517-0  1
2001 Day HE, Badiani A, Uslaner JM, Oates MM, Vittoz NM, Robinson TE, Watson SJ, Akil H. Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 732-40. PMID 11160452  1
2000 Watson SJ, Meng F, Thompson RC, Akil H. The "chip" as a specific genetic tool. Biological Psychiatry. 48: 1147-56. PMID 11137056  1
2000 Kabbaj M, Devine DP, Savage VR, Akil H. Neurobiological correlates of individual differences in novelty-seeking behavior in the rat: differential expression of stress-related molecules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6983-8. PMID 10995843  1
2000 Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. Hormonal evidence for altered responsiveness to social stress in major depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: 411-8. PMID 10989268 DOI: 10.1016/S0893-133X(00)00129-9  1
2000 Bonner G, Meng F, Akil H. Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop. European Journal of Pharmacology. 403: 37-44. PMID 10969141  0.48
2000 López-Figueroa MO, Caamaño C, Morano MI, Rønn LC, Akil H, Watson SJ. Direct evidence of nitric oxide presence within mitochondria. Biochemical and Biophysical Research Communications. 272: 129-33. PMID 10872815 DOI: 10.1006/bbrc.2000.2748  1
2000 Lee SP, O'Dowd BF, Ng GY, Varghese G, Akil H, Mansour A, Nguyen T, George SR. Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell. Molecular Pharmacology. 58: 120-8. PMID 10860933  1
2000 Lu XY, Bagnol D, Burke S, Akil H, Watson SJ. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Hormones and Behavior. 37: 335-44. PMID 10860677 DOI: 10.1006/hbeh.2000.1584  1
2000 Meng F, Wei Q, Hoversten MT, Taylor LP, Akil H. Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor. The Journal of Biological Chemistry. 275: 21939-45. PMID 10777506 DOI: 10.1074/jbc.M002864200  1
2000 López-Figueroa MO, Day HE, Lee S, Rivier C, Akil H, Watson SJ. Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation. Brain Research. 852: 239-46. PMID 10661521 DOI: 10.1016/S0006-8993(99)02241-6  1
2000 Akil H, Watson SJ. Science and the future of psychiatry. Archives of General Psychiatry. 57: 86-7. PMID 10632238  1
1999 López JF, Akil H, Watson SJ. Neural circuits mediating stress. Biological Psychiatry. 46: 1461-71. PMID 10599476  1
1999 Lu Xy, Gunn TM, Shieh Kr, Barsh GS, Akil H, Watson SJ. Distribution of Mahogany/Attractin mRNA in the rat central nervous system. Febs Letters. 462: 101-7. PMID 10580100 DOI: 10.1016/S0014-5793(99)01494-5  1
1999 Day HE, Campeau S, Watson SJ, Akil H. Expression of alpha(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10098-106. PMID 10559417  1
1999 Neilan CL, Akil H, Woods JH, Traynor JR. Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. British Journal of Pharmacology. 128: 556-62. PMID 10516632 DOI: 10.1038/sj.bjp.0702816  1
1999 Badiani A, Oates MM, Day HE, Watson SJ, Akil H, Robinson TE. Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons. Behavioural Brain Research. 103: 203-9. PMID 10513588 DOI: 10.1016/S0166-4328(99)00041-8  1
1999 Lee KO, Akil H, Woods JH, Traynor JR. Differential binding properties of oripavines at cloned mu- and delta-opioid receptors. European Journal of Pharmacology. 378: 323-30. PMID 10493109 DOI: 10.1016/S0014-2999(99)00460-4  1
1999 Bagnol D, Lu XY, Kaelin CB, Day HE, Ollmann M, Gantz I, Akil H, Barsh GS, Watson SJ. Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: RC26. PMID 10479719  1
1999 Day HE, Curran EJ, Watson SJ, Akil H. Distinct neurochemical populations in the rat central nucleus of the amygdala and bed nucleus of the stria terminalis: evidence for their selective activation by interleukin-1beta. The Journal of Comparative Neurology. 413: 113-28. PMID 10464374 DOI: 10.1002/(SICI)1096-9861(19991011)413:1<113::AID-CNE8>3.0.CO;2-B  1
1999 Neal CR, Mansour A, Reinscheid R, Nothacker HP, Civelli O, Akil H, Watson SJ. Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding. The Journal of Comparative Neurology. 412: 563-605. PMID 10464356 DOI: 10.1002/(SICI)1096-9861(19991004)412:4<563::AID-CNE2>3.0.CO;2-Z  1
1999 Day HE, Akil H. Evidence that cholecystokinin receptors are not involved in the hypothalamic-pituitary-adrenal response to intraperitoneal administration of interleukin-1beta. Journal of Neuroendocrinology. 11: 561-8. PMID 10444313  0.68
1999 Kollack-Walker S, Don C, Watson SJ, Akil H. Differential expression of c-fos mRNA within neurocircuits of male hamsters exposed to acute or chronic defeat. Journal of Neuroendocrinology. 11: 547-59. PMID 10444312  1
1999 Watson SJ, Akil H. Gene chips and arrays revealed: a primer on their power and their uses. Biological Psychiatry. 45: 533-43. PMID 10088043  1
1999 Helmreich DL, Watkins LR, Deak T, Maier SF, Akil H, Watson SJ. The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology. 11: 121-8. PMID 10048467 DOI: 10.1046/j.1365-2826.1999.00300.x  1
1999 Remmers AE, Clark MJ, Mansour A, Akil H, Woods JH, Medzihradsky F. Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 288: 827-33. PMID 9918595  1
1998 Va Zquez DM, Lo Pez JF, Morano MA, Kwak SP, Watson SJ, Akil H. α, β, and γ Mineralocorticoid Receptor Messenger Ribonucleic Acid Splice Variants: Differential Expression and Rapid Regulation in the Developing Hippocampus. Endocrinology. 139: 3165-3177. PMID 28200470 DOI: 10.1210/endo.139.7.6095  1
1998 Badiani A, Oates MM, Day HE, Watson SJ, Akil H, Robinson TE. Amphetamine-induced behavior, dopamine release, and c-fos mRNA expression: modulation by environmental novelty. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10579-93. PMID 9852594  1
1998 López-Figueroa MO, Day HE, Akil H, Watson SJ. Nitric oxide in the stress axis. Histology and Histopathology. 13: 1243-52. PMID 9810515  1
1998 Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. The role of mineralocorticoid receptors in hypothalamic-pituitary-adrenal axis regulation in humans. The Journal of Clinical Endocrinology and Metabolism. 83: 3339-45. PMID 9745451 DOI: 10.1210/jcem.83.9.5077  1
1998 Akil H, Owens C, Gutstein H, Taylor L, Curran E, Watson S. Endogenous opioids: overview and current issues. Drug and Alcohol Dependence. 51: 127-40. PMID 9716935  0.96
1998 Caamaño CA, Morano MI, Dalman FC, Pratt WB, Akil H. A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling. The Journal of Biological Chemistry. 273: 20473-80. PMID 9685402 DOI: 10.1074/jbc.273.32.20473  1
1998 Gutstein HB, Thome JL, Fine JL, Watson SJ, Akil H. Pattern of c-fos mRNA induction in rat brain by acute morphine. Canadian Journal of Physiology and Pharmacology. 76: 294-303. PMID 9673793 DOI: 10.1139/cjpp-76-3-294  1
1998 Gutstein HB, Mansour A, Watson SJ, Akil H, Fields HL. Mu and kappa opioid receptors in periaqueductal gray and rostral ventromedial medulla. Neuroreport. 9: 1777-81. PMID 9665599  1
1998 Alt A, Mansour A, Akil H, Medzihradsky F, Traynor JR, Woods JH. Stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding by endogenous opioids acting at a cloned mu receptor. The Journal of Pharmacology and Experimental Therapeutics. 286: 282-8. PMID 9655870  1
1998 Vázquez DM, López JF, Morano MI, Kwak SP, Watson SJ, Akil H. Alpha, beta, and gamma mineralocorticoid receptor messenger ribonucleic acid splice variants: differential expression and rapid regulation in the developing hippocampus. Endocrinology. 139: 3165-77. PMID 9645690 DOI: 10.1210/endo.139.7.6095  1
1998 Meng F, Ueda Y, Hoversten MT, Taylor LP, Reinscheid RK, Monsma FJ, Watson SJ, Civelli O, Akil H. Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis. Molecular Pharmacology. 53: 772-7. PMID 9547370  1
1998 Coward P, Wada HG, Falk MS, Chan SD, Meng F, Akil H, Conklin BR. Controlling signaling with a specifically designed Gi-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 95: 352-7. PMID 9419379 DOI: 10.1073/pnas.95.1.352  1
1997 Vázquez DM, Morano MI, Taylor L, Akil H. Kinetics of radiolabeled adrenocorticotropin hormone in infant and weanling rats. Journal of Neuroendocrinology. 9: 529-36. PMID 15305571  0.88
1997 Helmreich DL, Morano MI, Akil H, Watson SJ. Correlation between Changes in Stress-Induced Corticosterone Secretion and GR mRNA Levels. Stress (Amsterdam, Netherlands). 2: 101-112. PMID 9787259  1
1997 Liberzon I, Trujillo KA, Akil H, Young EA. Motivational properties of oxytocin in the conditioned place preference paradigm. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 17: 353-9. PMID 9397423 DOI: 10.1016/S0893-133X(97)00070-5  1
1997 Emmerson PJ, Archer S, El-Hamouly W, Mansour A, Akil H, Medzihradsky F. Synthesis and characterization of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-labeled fluorescent ligands for the mu opioid receptor. Biochemical Pharmacology. 54: 1315-22. PMID 9393674  0.72
1997 Gutstein HB, Rubie EA, Mansour A, Akil H, Woodgett JR. Opioid effects on mitogen-activated protein kinase signaling cascades. Anesthesiology. 87: 1118-26. PMID 9366464 DOI: 10.1097/00000542-199711000-00016  1
1997 Clark MJ, Emmerson PJ, Mansour A, Akil H, Woods JH, Portoghese PS, Remmers AE, Medzihradsky F. Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 283: 501-10. PMID 9353363  1
1997 Kollack-Walker S, Watson SJ, Akil H. Social stress in hamsters: defeat activates specific neurocircuits within the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8842-55. PMID 9348352  1
1997 Bagnol D, Mansour A, Akil H, Watson SJ. Cellular localization and distribution of the cloned mu and kappa opioid receptors in rat gastrointestinal tract. Neuroscience. 81: 579-91. PMID 9300443  1
1997 Day HE, Campeau S, Watson SJ, Akil H. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. Journal of Chemical Neuroanatomy. 13: 115-39. PMID 9285356 DOI: 10.1016/S0891-0618(97)00042-2  1
1997 Campeau S, Akil H, Watson SJ. Lesions of the medial geniculate nuclei specifically block corticosterone release and induction of c-fos mRNA in the forebrain associated with audiogenic stress in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5979-92. PMID 9221794  1
1997 Ruzicka BB, Akil H. The interleukin-1beta-mediated regulation of proenkephalin and opioid receptor messenger RNA in primary astrocyte-enriched cultures. Neuroscience. 79: 517-24. PMID 9200734  0.4
1997 Fickel J, Bagnol D, Watson SJ, Akil H. Opioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brain. Brain Research. Molecular Brain Research. 46: 1-8. PMID 9191072  1
1997 Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. Normal pituitary response to metyrapone in the morning in depressed patients: implications for circadian regulation of corticotropin-releasing hormone secretion. Biological Psychiatry. 41: 1149-55. PMID 9171905  1
1997 Mansour A, Taylor LP, Fine JL, Thompson RC, Hoversten MT, Mosberg HI, Watson SJ, Akil H. Key residues defining the mu-opioid receptor binding pocket: a site-directed mutagenesis study. Journal of Neurochemistry. 68: 344-53. PMID 8978745  1
1996 Watson B, Meng F, Akil H. A chimeric analysis of the opioid receptor domains critical for the binding selectivity of mu opioid ligands. Neurobiology of Disease. 3: 87-96. PMID 9173916 DOI: 10.1006/nbdi.1996.0009  0.48
1996 Curran EJ, Akil H, Watson SJ. Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals. Neurochemical Research. 21: 1425-35. PMID 8947933  1
1996 Devine DP, Taylor L, Reinscheid RK, Monsma FJ, Civelli O, Akil H. Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ. Neurochemical Research. 21: 1387-96. PMID 8947929 DOI: 10.1007/BF02532380  1
1996 Meng F, Taylor LP, Hoversten MT, Ueda Y, Ardati A, Reinscheid RK, Monsma FJ, Watson SJ, Civelli O, Akil H. Moving from the orphanin FQ receptor to an opioid receptor using four point mutations. The Journal of Biological Chemistry. 271: 32016-20. PMID 8943250 DOI: 10.1074/jbc.271.50.32016  1
1996 Cho W, Taylor LP, Akil H. Mutagenesis of residues adjacent to transmembrane prolines alters D1 dopamine receptor binding and signal transduction. Molecular Pharmacology. 50: 1338-45. PMID 8913366  0.48
1996 Cucumel K, Garreau I, Mery J, Moinier D, Mansour A, Akil H, Cupo A. Production and characterization of site-directed antibodies against dermorphin and dermorphin-related peptides. Peptides. 17: 973-82. PMID 8899816  0.72
1996 Meng F, Ueda Y, Hoversten MT, Thompson RC, Taylor L, Watson SJ, Akil H. Mapping the receptor domains critical for the binding selectivity of delta-opioid receptor ligands. European Journal of Pharmacology. 311: 285-92. PMID 8891611 DOI: 10.1016/0014-2999(96)00431-1  1
1996 Vázquez DM, Van Oers H, Levine S, Akil H. Regulation of glucocorticoid and mineralocorticoid receptor mRNAs in the hippocampus of the maternally deprived infant rat. Brain Research. 731: 79-90. PMID 8883857  0.68
1996 Mansour A, Burke S, Pavlic RJ, Akil H, Watson SJ. Immunohistochemical localization of the cloned kappa 1 receptor in the rat CNS and pituitary. Neuroscience. 71: 671-90. PMID 8867040  1
1996 Devine DP, Reinscheid RK, Monsma FJ, Civelli O, Akil H. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion. Brain Research. 727: 225-9. PMID 8842403 DOI: 10.1016/0006-8993(96)00476-3  1
1996 Emmerson PJ, Clark MJ, Mansour A, Akil H, Woods JH, Medzihradsky F. Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 278: 1121-7. PMID 8819494  0.72
1996 Akil H, Meng F, Mansour A, Thompson R, Xie GX, Watson S. Cloning and characterization of multiple opioid receptors. Nida Research Monograph. 161: 127-40. PMID 8784848  0.96
1996 Day HE, Akil H. Differential pattern of c-fos mRNA in rat brain following central and systemic administration of interleukin-1-beta: implications for mechanism of action. Neuroendocrinology. 63: 207-18. PMID 8677009  0.68
1996 Ruzicka BB, Thompson RC, Watson SJ, Akil H. Interleukin-1 beta-mediated regulation of mu-opioid receptor mRNA in primary astrocyte-enriched cultures. Journal of Neurochemistry. 66: 425-8. PMID 8522984  1
1995 Ruzicka BB, Fox CA, Thompson RC, Meng F, Watson SJ, Akil H. Primary astroglial cultures derived from several rat brain regions differentially express mu, delta and kappa opioid receptor mRNA. Brain Research. Molecular Brain Research. 34: 209-20. PMID 8750824 DOI: 10.1016/0169-328X(95)00165-O  1
1995 Mansour A, Hoversten MT, Taylor LP, Watson SJ, Akil H. The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Research. 700: 89-98. PMID 8624732 DOI: 10.1016/0006-8993(95)00928-J  1
1995 Trujillo KA, Bronstein DM, Sanchez IO, Akil H. Effects of chronic opiate and opioid antagonist treatment on striatal opioid peptides. Brain Research. 698: 69-78. PMID 8581505 DOI: 10.1016/0006-8993(95)00809-5  1
1995 Young EA, Akil H, Haskett RF, Watson SJ. Evidence against changes in corticotroph CRF receptors in depressed patients. Biological Psychiatry. 37: 355-63. PMID 7772643 DOI: 10.1016/0006-3223(94)00153-T  1
1995 Meng F, Hoversten MT, Thompson RC, Taylor L, Watson SJ, Akil H. A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains. The Journal of Biological Chemistry. 270: 12730-6. PMID 7759527  1
1995 Badiani A, Morano MI, Akil H, Robinson TE. Circulating adrenal hormones are not necessary for the development of sensitization to the psychomotor activating effects of amphetamine. Brain Research. 673: 13-24. PMID 7757465 DOI: 10.1016/0006-8993(94)01365-O  1
1995 Cullinan WE, Herman JP, Battaglia DF, Akil H, Watson SJ. Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience. 64: 477-505. PMID 7700534 DOI: 10.1016/0306-4522(94)00355-9  1
1995 Trujillo KA, Akil H. Excitatory amino acids and drugs of abuse: a role for N-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence. Drug and Alcohol Dependence. 38: 139-54. PMID 7671766 DOI: 10.1016/0376-8716(95)01119-J  1
1995 Mansour A, Fox CA, Burke S, Akil H, Watson SJ. Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS. Journal of Chemical Neuroanatomy. 8: 283-305. PMID 7669273 DOI: 10.1016/0891-0618(95)00055-C  1
1995 Gutstein HB, Trujillo KA, Akil H. Does chronic nociceptive stimulation alter the development of morphine tolerance? Brain Research. 680: 173-9. PMID 7663975 DOI: 10.1016/0006-8993(95)00259-S  1
1995 Caamaño CA, Morano MI, Dalman FC, Hoversten MT, Watson SJ, Pratt WB, Akil H. Point mutations in the 90-kDa heat shock protein binding region of the glucocorticoid receptor affect the functional characteristics of the receptor. Annals of the New York Academy of Sciences. 761: 403-4. PMID 7625747 DOI: 10.1111/j.1749-6632.1995.tb31403.x  1
1995 Cho W, Taylor LP, Mansour A, Akil H. Hydrophobic residues of the D2 dopamine receptor are important for binding and signal transduction. Journal of Neurochemistry. 65: 2105-15. PMID 7595496  0.72
1995 Herman JP, Cullinan WE, Morano MI, Akil H, Watson SJ. Contribution of the ventral subiculum to inhibitory regulation of the hypothalamo-pituitary-adrenocortical axis. Journal of Neuroendocrinology. 7: 475-82. PMID 7550295 DOI: 10.1111/j.1365-2826.1995.tb00784.x  1
1995 Ruzicka BB, Akil H. Differential cellular regulation of pro-opiomelanocortin by interleukin-1-beta and corticotropin-releasing hormone. Neuroendocrinology. 61: 136-51. PMID 7538634  0.4
1995 Mansour A, Watson SJ, Akil H. Opioid receptors: past, present and future. Trends in Neurosciences. 18: 69-70. PMID 7537414  1
1995 Mansour A, Fox CA, Akil H, Watson SJ. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends in Neurosciences. 18: 22-9. PMID 7535487 DOI: 10.1016/0166-2236(95)93946-U  1
1994 Dupuy A, Lindberg I, Zhou Y, Akil H, Lazure C, Chrétien M, Seidah NG, Day R. Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue. Febs Letters. 337: 60-5. PMID 8276115  0.72
1994 López JF, Chalmers DT, Vázquez DM, Watson SJ, Akil H. Serotonin transporter mRNA in rat brain is regulated by classical antidepressants. Biological Psychiatry. 35: 287-90. PMID 8186335  1
1994 Xie GX, Meng F, Mansour A, Thompson RC, Hoversten MT, Goldstein A, Watson SJ, Akil H. Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 3779-83. PMID 8170987  1
1994 Trujillo KA, Akil H. Inhibition of opiate tolerance by non-competitive N-methyl-D-aspartate receptor antagonists. Brain Research. 633: 178-88. PMID 8137155 DOI: 10.1016/0006-8993(94)91538-5  1
1994 Young EA, Haskett RF, Grunhaus L, Pande A, Weinberg VM, Watson SJ, Akil H. Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients. Archives of General Psychiatry. 51: 701-7. PMID 8080346  1
1994 Meng F, Xie GX, Chalmers D, Morgan C, Watson SJ, Akil H. Cloning and expression of the A2a adenosine receptor from guinea pig brain. Neurochemical Research. 19: 613-21. PMID 8065518  1
1994 Mansour A, Fox CA, Thompson RC, Akil H, Watson SJ. mu-Opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding. Brain Research. 643: 245-65. PMID 8032920 DOI: 10.1016/0006-8993(94)90031-0  1
1994 Mansour A, Fox CA, Meng F, Akil H, Watson SJ. Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA. Molecular and Cellular Neurosciences. 5: 124-44. PMID 8032682 DOI: 10.1006/mcne.1994.1015  1
1994 Akil H, Watson SJ. Cloning of kappa opioid receptors: functional significance and future directions. Progress in Brain Research. 100: 81-6. PMID 7938538  1
1994 Chalmers DT, López JF, Vázquez DM, Akil H, Watson SJ. Regulation of hippocampal 5-HT1A receptor gene expression by dexamethasone. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 10: 215-22. PMID 7916919 DOI: 10.1038/npp.1994.24  1
1994 Mansour A, Fox CA, Burke S, Meng F, Thompson RC, Akil H, Watson SJ. Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. The Journal of Comparative Neurology. 350: 412-38. PMID 7884049 DOI: 10.1002/cne.903500307  1
1994 Meng F, Xie GX, Chalmers D, Morgan C, Watson SJ, Akil H. Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain. Brain Research. Molecular Brain Research. 26: 143-55. PMID 7854041  1
1994 Caamaño CA, Morano MI, Watson SJ, Dalman FC, Pratt WB, Akil H. The functional relevance of the heteromeric structure of corticosteroid receptors. Annals of the New York Academy of Sciences. 746: 68-77; discussion 77. PMID 7825922  1
1994 Morano MI, Vázquez DM, Akil H. The role of the hippocampal mineralocorticoid and glucocorticoid receptors in the hypothalamo-pituitary-adrenal axis of the aged Fisher rat. Molecular and Cellular Neurosciences. 5: 400-12. PMID 7820364 DOI: 10.1006/mcne.1994.1050  0.88
1993 Vázquez DM, Morano MI, López JF, Watson SJ, Akil H. Short-term adrenalectomy increases glucocorticoid and mineralocorticoid receptor mRNA in selective areas of the developing hippocampus. Molecular and Cellular Neurosciences. 4: 455-71. PMID 19912953 DOI: 10.1006/mcne.1993.1057  1
1993 Bronstein DM, Gutstein HB, Akil H. Effects of chronic morphine treatment on beta-endorphin-related peptides in the caudal medulla and spinal cord. Journal of Neurochemistry. 60: 2304-7. PMID 8492132  1
1993 Young EA, Kotun J, Haskett RF, Grunhaus L, Greden JF, Watson SJ, Akil H. Dissociation between pituitary and adrenal suppression to dexamethasone in depression. Archives of General Psychiatry. 50: 395-403. PMID 8489328  1
1993 Young EA, Przewlocki R, Patel P, Watson SJ, Akil H. Altered ratios of beta-endorphin: beta-lipotropin released from anterior lobe corticotropes with increased secretory drive. I. Effects of diminished glucocorticoid secretion. Journal of Neuroendocrinology. 5: 115-20. PMID 8485540  1
1993 Chalmers DT, Kwak SP, Mansour A, Akil H, Watson SJ. Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 914-23. PMID 8441016  1
1993 Bronstein DM, Day NC, Gutstein HB, Trujillo KA, Akil H. Pre- and posttranslational regulation of beta-endorphin biosynthesis in the CNS: effects of chronic naltrexone treatment. Journal of Neurochemistry. 60: 40-9. PMID 8417165  1
1993 Kwak SP, Patel PD, Thompson RC, Akil H, Watson SJ. 5'-Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus. Endocrinology. 133: 2344-50. PMID 8404687 DOI: 10.1210/endo.133.5.8404687  1
1993 Caamaño CA, Morano MI, Patel PD, Watson SJ, Akil H. A bacterially expressed mineralocorticoid receptor is associated in vitro with the 90-kilodalton heat shock protein and shows typical hormone- and DNA-binding characteristics. Biochemistry. 32: 8589-95. PMID 8395210  1
1993 Young EA, Day R, Schafer M, Watson SJ, Akil H. Altered ratios of beta-endorphin:beta-lipotropin released from anterior lobe corticotropes with increased secretory drive. II. Repeated stress. Journal of Neuroendocrinology. 5: 121-6. PMID 8387374  1
1993 Kwak SP, Morano MI, Young EA, Watson SJ, Akil H. Diurnal CRH mRNA rhythm in the hypothalamus: decreased expression in the evening is not dependent on endogenous glucocorticoids. Neuroendocrinology. 57: 96-105. PMID 8386819  1
1993 Akil H, Haskett RF, Young EA, Grunhaus L, Kotun J, Weinberg V, Greden J, Watson SJ. Multiple HPA profiles in endogenous depression: effect of age and sex on cortisol and beta-endorphin. Biological Psychiatry. 33: 73-85. PMID 8382535  1
1993 Day NC, Lin H, Ueda Y, Meador-Woodruff JH, Akil H. Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA. Neuropeptides. 24: 253-62. PMID 8327069 DOI: 10.1016/0143-4179(93)90013-Z  1
1993 Vázquez DM, Akil H. Pituitary-adrenal response to ether vapor in the weanling animal: characterization of the inhibitory effect of glucocorticoids on adrenocorticotropin secretion. Pediatric Research. 34: 646-53. PMID 8284104 DOI: 10.1203/00006450-199311000-00017  0.68
1993 Young EA, Bronstein D, Akil H. Dopamine regulation of swim stress induction of the pituitary intermediate lobe proopiomelanocortin system. Neuroendocrinology. 58: 294-302. PMID 8255390 DOI: 10.1159/000126553  1
1993 Day R, Schäfer MK, Collard MW, Weihe E, Akil H. Prodynorphin gene expression in the rat intermediate pituitary lobe: gender differences and postpartum regulation. Endocrinology. 133: 2652-9. PMID 8243288 DOI: 10.1210/endo.133.6.8243288  0.72
1993 Thompson RC, Mansour A, Akil H, Watson SJ. Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron. 11: 903-13. PMID 8240812  1
1993 Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, Akil H. Cloning and pharmacological characterization of a rat kappa opioid receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 9954-8. PMID 8234341  1
1993 Mansour A, Thompson RC, Akil H, Watson SJ. Delta opioid receptor mRNA distribution in the brain: comparison to delta receptor binding and proenkephalin mRNA. Journal of Chemical Neuroanatomy. 6: 351-62. PMID 8142072  1
1993 Lin HL, Day NC, Ueda Y, Martin DK, Dixon JE, Seidah NG, Akil H. Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs. Neuroendocrinology. 58: 94-105. PMID 7903430  0.48
1992 Mansour A, Meador-Woodruff JH, Zhou Q, Civelli O, Akil H, Watson SJ. A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques. Neuroscience. 46: 959-71. PMID 1531866 DOI: 10.1016/0306-4522(92)90197-A  1
1992 Mansour A, Meng F, Meador-Woodruff JH, Taylor LP, Civelli O, Akil H. Site-directed mutagenesis of the human dopamine D2 receptor. European Journal of Pharmacology. 227: 205-14. PMID 1358663 DOI: 10.1016/0922-4106(92)90129-J  1
1992 Gutstein HB, Bronstein DM, Akil H. Beta-endorphin processing and cellular origins in rat spinal cord. Pain. 51: 241-7. PMID 1336592 DOI: 10.1016/0304-3959(92)90265-D  1
1992 Herman JP, Cullinan WE, Young EA, Akil H, Watson SJ. Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Research. 592: 228-38. PMID 1333341 DOI: 10.1016/0006-8993(92)91680-D  1
1991 Meador-Woodruff JH, Mansour A, Healy DJ, Kuehn R, Zhou QY, Bunzow JR, Akil H, Civelli O, Watson SJ. Comparison of the distributions of D1 and D2 dopamine receptor mRNAs in rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 5: 231-42. PMID 1839499  1
1991 Trujillo KA, Akil H. The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality Pharmacology, Biochemistry and Behavior. 38: 673-675. PMID 1829839 DOI: 10.1016/0091-3057(91)90032-W  1
1991 Trujillo KA, Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801 Science. 251: 85-87. PMID 1824728  1
1991 Mansour A, Meador-Woodruff JH, Zhou QY, Civelli O, Akil H, Watson SJ. A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques. Neuroscience. 45: 359-71. PMID 1762683 DOI: 10.1016/0306-4522(91)90233-E  1
1991 Trujillo KA, Akil H. Opioid and non-opioid behavioral actions of dynorphin A and the dynorphin analogue DAKLI Nida Research Monograph. 105: 397-398. PMID 1678871  1
1991 Trujillo KA, Akil H. Opiate tolerance and dependence: recent findings and synthesis The New Biologist. 3: 915-923. PMID 1662985  1
1990 Trujillo KA, Akil H. Pharmacological regulation of striatal prodynorphin peptides Progress in Clinical and Biological Research. 328: 223-226. PMID 2304946  1
1990 Mansour A, Meador-Woodruff JH, Bunzow JR, Civelli O, Akil H, Watson SJ. Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2587-600. PMID 2143777  1
1990 Meador-Woodruff JH, Pellerito B, Bronstein D, Lin HL, Ling N, Akil H. Differential effects of haloperidol on the rat pituitary: decreased biosynthesis, processing and release of anterior lobe pro-opiomelanocortin. Neuroendocrinology. 51: 294-303. PMID 2109273  1
1990 Mansour A, Meador-Woodruff JH, Camp DM, Robinson TE, Bunzow J, Van Tol H, Civelli O, Akil H, Watson SJ. The effects of nigrostriatal 6-hydroxydopamine lesions on dopamine D2 receptor mRNA and opioid systems. Progress in Clinical and Biological Research. 328: 227-30. PMID 2106148  1
1990 Trujillo KA, Day R, Akil H. Regulation of striatonigral prodynorphin peptides by dopaminergic agents Brain Research. 518: 244-256. PMID 1975215 DOI: 10.1016/0006-8993(90)90977-J  1
1989 Trujillo KA, Akil H. Changes in prodynorphin peptide content following treatment with morphine or amphetamine: Possible role in mechanisms of action of drug of abuse Nida Research Monograph Series. 550-551. PMID 2561855  1
1989 Meador-Woodruff JH, Silk KR, Kronfol Z, Watson SJ, Akil H. Gamma-melanotropin and beta-endorphin after dexamethasone. Biological Psychiatry. 25: 975-6. PMID 2541805 DOI: 10.1016/0006-3223(89)90278-3  1
1988 Meador-Woodruff JH, Pellerito B, Vaudry H, Jégou S, Seidah NG, Watson SJ, Akil H. Regional processing of the N- and C-terminal domains of proopiomelanocortin in monkey pituitary and brain. Neuropeptides. 11: 111-8. PMID 2968525 DOI: 10.1016/0143-4179(88)90079-0  1
1987 Meador-Woodruff JH, Watson SJ, Murphy-Weinberg V, Jegou S, Vaudry H, Seidah NG, Rivier J, Vale W, Akil H. Gamma-melanotropin response to ovine corticotropin releasing factor in normal humans. Neuropeptides. 9: 269-82. PMID 3497356 DOI: 10.1016/0143-4179(87)90002-3  1
1987 Meador-Woodruff JH, Haskett RF, Grunhaus L, Akil H, Watson SJ, Greden JF. Postdexamethasone plasma cortisol and beta-endorphin levels in depression: relationship to severity of illness. Biological Psychiatry. 22: 1137-50. PMID 2958096 DOI: 10.1016/0006-3223(87)90055-2  1
1987 Robinson TE, Becker JB, Young EA, Akil H, Castaneda E. The effects of footshock stress on regional brain dopamine metabolism and pituitary beta-endorphin release in rats previously sensitized to amphetamine. Neuropharmacology. 26: 679-91. PMID 2957606 DOI: 10.1016/0028-3908(87)90228-0  1
1987 Walker JM, Coy DH, Young EA, Baldrighi G, Siegel SF, Bowen WD, Akil H. [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN): a potent analog of dynorphin 1-13. Peptides. 8: 811-7. PMID 2893357 DOI: 10.1016/0196-9781(87)90064-7  1
1987 Walker JM, Ghessari A, Peters BA, Watson SJ, Seidah N, Chretien M, Akil H. Functional aspects of multitransmitter neurons. Studies of interactions among pro-opiomelanocortin products. Pain and Headache. 9: 160-77. PMID 2891130  1
1987 Young EA, Walker JM, Houghten R, Akil H. The degradation of dynorphin A in brain tissue in vivo and in vitro. Peptides. 8: 701-7. PMID 2888101 DOI: 10.1016/0196-9781(87)90046-5  1
1986 Akil H, Young E, Walker JM, Watson SJ. The many possible roles of opioids and related peptides in stress-induced analgesia. Annals of the New York Academy of Sciences. 467: 140-53. PMID 2942087  1
1986 Young EA, Walker JM, Lewis ME, Houghten RA, Woods JH, Akil H. [3H]dynorphin A binding and kappa selectivity of prodynorphin peptides in rat, guinea-pig and monkey brain. European Journal of Pharmacology. 121: 355-65. PMID 2870933  1
1984 Akil H, Watson SJ, Young E, Lewis ME, Khachaturian H, Walker JM. Endogenous opioids: biology and function. Annual Review of Neuroscience. 7: 223-55. PMID 6324644 DOI: 10.1146/annurev.ne.07.030184.001255  1
1983 Young E, Walker JM, Houghten R, Akil H. [3H] dynorphin binding to guinea pig and rat brain. Life Sciences. 33: 287-90. PMID 6141490  1
1983 Young EA, Walker JM, Houghten R, Akil H. [3H]Dynorphin A binds selectively to guinea pig brain. European Journal of Pharmacology. 91: 327-8. PMID 6137397 DOI: 10.1016/0014-2999(83)90489-2  1
1982 Walker JM, Tucker DE, Coy DH, Walker BB, Akil H. Des-tyrosine-dynorphin antagonizes morphine analgesia. European Journal of Pharmacology. 85: 121-2. PMID 7151859  1
1982 Akil H, Shiomi H, Walker JM, Watson SJ. Characterization of multiple forms of beta-E in pituitary and brain: effect of stress. Advances in Biochemical Psychopharmacology. 33: 61-7. PMID 6289633  1
1982 Walker JM, Moises HC, Coy DH, Young EA, Watson SJ, Akil H. Dynorphin (1-17): lack of analgesia but evidence for non-opiate electrophysiological and motor effects. Life Sciences. 31: 1821-4. PMID 6130448  1
1982 Walker JM, Moises HC, Coy DH, Baldrighi G, Akil H. Nonopiate effects of dynorphin and des-Tyr-dynorphin. Science (New York, N.Y.). 218: 1136-8. PMID 6128791  1
1981 Walker JM, Berntson GG, Sandman CA, Kastin AJ, Akil H. Induction of analgesia by central administration of ORG 2766, an analog of ACTH4--9. European Journal of Pharmacology. 69: 71-9. PMID 6258942 DOI: 10.1016/0014-2999(81)90603-8  1
1980 Walker JM, Katz RJ, Akil H. Behavioral effects of dynorphin 1-13 in the mouse and rat: initial observations. Peptides. 1: 341-5. PMID 7301637  1
1980 Walker JM, Akil H, Watson SJ. Evidence for homologous actions of pro-opiocortin products. Science (New York, N.Y.). 210: 1247-9. PMID 6254152  1
1976 Akil H, Mayer DJ, Liebeskind JC. Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science (New York, N.Y.). 191: 961-2. PMID 1251210  1
1975 Akil H, Liebeskind JC. Monoaminergic mechanisms of stimulation-produced analgesia. Brain Research. 94: 279-96. PMID 125141 DOI: 10.1016/0006-8993(75)90062-1  1
1972 Akil H, Mayer DJ, Liebeskind JC. [Monoaminergic mechanisms involved in analgesia caused by stimulation of the brain stem in rats]. Journal De Physiologie. 65: Suppl:185A. PMID 4265385  1
1972 Akil H, Mayer DJ, Liebeskind JC. [Comparison in the rat between analgesia induced by stimulation of periacqueducal gray matter and morphine analgesia]. Comptes Rendus Hebdomadaires Des SéAnces De L'AcadéMie Des Sciences. SéRie D: Sciences Naturelles. 274: 3603-5. PMID 4265157  1
1971 Mayer DJ, Wolfle TL, Akil H, Carder B, Liebeskind JC. Analgesia from electrical stimulation in the brainstem of the rat. Science (New York, N.Y.). 174: 1351-4. PMID 5167502  1
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