| Year |
Citation |
Score |
| 2023 |
Milano L, Gautam A, Caldecott KW. DNA damage and transcription stress. Molecular Cell. 84: 70-79. PMID 38103560 DOI: 10.1016/j.molcel.2023.11.014 |
0.534 |
|
| 2023 |
Caldecott KW. Causes and consequences of DNA single-strand breaks. Trends in Biochemical Sciences. 49: 68-78. PMID 38040599 DOI: 10.1016/j.tibs.2023.11.001 |
0.526 |
|
| 2023 |
Thuresson AC, Brazina J, Akram T, Albrecht J, Dahl N, Soussi Zander C, Caldecott KW. Novel PNKP mutations associated with reduced DNA single-strand break repair and severe microcephaly, seizures, and developmental delay. Molecular Genetics & Genomic Medicine. e2295. PMID 37916443 DOI: 10.1002/mgg3.2295 |
0.429 |
|
| 2023 |
Gautam A, Fawcett H, Burdova K, Brazina J, Caldecott KW. APE1-dependent base excision repair of DNA photodimers in human cells. Molecular Cell. 83: 3669-3678.e7. PMID 37816354 DOI: 10.1016/j.molcel.2023.09.013 |
0.526 |
|
| 2023 |
Zagnoli-Vieira G, Brazina J, Van Den Bogaert K, Huybrechts W, Molenaers G, Caldecott KW, Van Esch H. Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. Human Genetics. 142: 1417-1427. PMID 37558815 DOI: 10.1007/s00439-023-02589-3 |
0.435 |
|
| 2023 |
Serrano-Benitez A, Wells SE, Drummond-Clarke L, Russo LC, Thomas JC, Leal GA, Farrow M, Edgerton JM, Balasubramanian S, Yang M, Frezza C, Gautam A, Brazina J, Burdova K, Hoch NC, ... ... Caldecott KW, et al. Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity. The Embo Journal. e113190. PMID 37492888 DOI: 10.15252/embj.2022113190 |
0.561 |
|
| 2023 |
Meroni A, Wells SE, Fonseca C, Ray Chaudhuri A, Caldecott KW, Vindigni A. DNA Combing DNA Spreading and the Separation of Sister Chromatids. Biorxiv : the Preprint Server For Biology. PMID 37205507 DOI: 10.1101/2023.05.02.539129 |
0.558 |
|
| 2022 |
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, ... Caldecott K, et al. Active DNA demethylation promotes cell fate specification and the DNA damage response. Science (New York, N.Y.). 378: 983-989. PMID 36454826 DOI: 10.1126/science.add9838 |
0.493 |
|
| 2022 |
Caldecott KW. DNA single-strand break repair and human genetic disease. Trends in Cell Biology. PMID 35643889 DOI: 10.1016/j.tcb.2022.04.010 |
0.564 |
|
| 2022 |
Vaitsiankova A, Burdova K, Sobol M, Gautam A, Benada O, Hanzlikova H, Caldecott KW. PARP inhibition impedes the maturation of nascent DNA strands during DNA replication. Nature Structural & Molecular Biology. 29: 329-338. PMID 35332322 DOI: 10.1038/s41594-022-00747-1 |
0.582 |
|
| 2022 |
Caldecott KW, Ward ME, Nussenzweig A. The threat of programmed DNA damage to neuronal genome integrity and plasticity. Nature Genetics. 54: 115-120. PMID 35145299 DOI: 10.1038/s41588-021-01001-y |
0.381 |
|
| 2021 |
Moser J, Kool H, Giakzidis I, Caldecott K, Mullenders LHF, Fousteri MI. Retraction Notice to: Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner. Molecular Cell. 81: 5113. PMID 34919822 DOI: 10.1016/j.molcel.2021.11.022 |
0.564 |
|
| 2021 |
Adamowicz M, Hailstone R, Demin AA, Komulainen E, Hanzlikova H, Brazina J, Gautam A, Wells SE, Caldecott KW. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nature Cell Biology. PMID 34811483 DOI: 10.1038/s41556-021-00792-w |
0.5 |
|
| 2021 |
Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW. XRCC1 prevents toxic PARP1 trapping during DNA base excision repair. Molecular Cell. PMID 34102106 DOI: 10.1016/j.molcel.2021.05.009 |
0.577 |
|
| 2021 |
Komulainen E, Badman J, Rey S, Rulten S, Ju L, Fennell K, Kalasova I, Ilievova K, McKinnon PJ, Hanzlikova H, Staras K, Caldecott KW. Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures. Embo Reports. 22: e51851. PMID 33932076 DOI: 10.15252/embr.202051851 |
0.357 |
|
| 2021 |
Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, ... ... Caldecott KW, et al. Neuronal enhancers are hotspots for DNA single-strand break repair. Nature. PMID 33767446 DOI: 10.1038/s41586-021-03468-5 |
0.491 |
|
| 2020 |
Caldecott KW. Mammalian DNA base excision repair: Dancing in the moonlight. Dna Repair. 93: 102921. PMID 33087262 DOI: 10.1016/j.dnarep.2020.102921 |
0.531 |
|
| 2020 |
Zagnoli-Vieira G, Caldecott KW. Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases. Dna Repair. 94: 102900. PMID 32653827 DOI: 10.1016/j.dnarep.2020.102900 |
0.558 |
|
| 2020 |
Errichiello E, Zagnoli-Vieira G, Rizzi R, Garavelli L, Caldecott KW, Zuffardi O. Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23). Journal of Human Genetics. PMID 32651480 DOI: 10.1038/s10038-020-0800-4 |
0.356 |
|
| 2020 |
Hanzlikova H, Prokhorova E, Krejcikova K, Cihlarova Z, Kalasova I, Kubovciak J, Sachova J, Hailstone R, Brazina J, Ghosh S, Cirak S, Gleeson JG, Ahel I, Caldecott KW. Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. Nature Communications. 11: 3391. PMID 32636369 DOI: 10.1038/S41467-020-17069-9 |
0.516 |
|
| 2020 |
Kalasova I, Hailstone R, Bublitz J, Bogantes J, Hofmann W, Leal A, Hanzlikova H, Caldecott KW. Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair. Nucleic Acids Research. PMID 32504494 DOI: 10.1093/nar/gkaa489 |
0.538 |
|
| 2019 |
Caldecott KW. XRCC1 protein; Form and function. Dna Repair. 102664. PMID 31324530 DOI: 10.1016/j.dnarep.2019.102664 |
0.567 |
|
| 2019 |
Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity. Molecular Cell. PMID 31202577 DOI: 10.1016/J.Molcel.2019.04.030 |
0.534 |
|
| 2019 |
Kalasova I, Hanzlikova H, Gupta N, Li Y, Altmüller J, Reynolds JJ, Stewart GS, Wollnik B, Yigit G, Caldecott KW. Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ. Neurology. Genetics. 5: e320. PMID 31041400 DOI: 10.1212/Nxg.0000000000000320 |
0.495 |
|
| 2019 |
Hanzlikova H, Caldecott KW. Perspectives on PARPs in S Phase. Trends in Genetics : Tig. PMID 31036342 DOI: 10.1016/j.tig.2019.03.008 |
0.46 |
|
| 2019 |
Martinez-Macias MI, Moore DA, Green RL, Gomez-Herreros F, Naumann M, Hermann A, Van Damme P, Hafezparast M, Caldecott KW. FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress. Life Science Alliance. 2. PMID 30808650 DOI: 10.26508/lsa.201800222 |
0.388 |
|
| 2019 |
Polo LM, Xu Y, Hornyak P, Garces F, Zeng Z, Hailstone R, Matthews SJ, Caldecott KW, Oliver AW, Pearl LH. Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1. Cell Reports. 26: 573-581.e5. PMID 30650352 DOI: 10.1016/j.celrep.2018.12.082 |
0.521 |
|
| 2018 |
Zagnoli-Vieira G, Bruni F, Thompson K, He L, Walker S, de Brouwer APM, Taylor R, Niyazov D, Caldecott KW. Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23). Neurology. Genetics. 4: e262. PMID 30109272 DOI: 10.1212/NXG.0000000000000262 |
0.444 |
|
| 2018 |
Hanzlikova H, Kalasova I, Demin AA, Pennicott LE, Cihlarova Z, Caldecott KW. The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication. Molecular Cell. 71: 319-331.e3. PMID 29983321 DOI: 10.1016/j.molcel.2018.06.004 |
0.542 |
|
| 2018 |
Yoon G, Caldecott KW. Nonsyndromic cerebellar ataxias associated with disorders of DNA single-strand break repair. Handbook of Clinical Neurology. 155: 105-115. PMID 29891053 DOI: 10.1016/B978-0-444-64189-2.00007-X |
0.545 |
|
| 2017 |
Zagnoli-Vieira G, Caldecott KW. TDP2, TOP2, and SUMO: what is ZATT about? Cell Research. PMID 29160298 DOI: 10.1038/cr.2017.147 |
0.392 |
|
| 2017 |
Zeng Z, Rulten SL, Breslin C, Zlatanou A, Coulthard V, Caldecott KW. Acylpeptide hydrolase is a component of the cellular response to DNA damage. Dna Repair. 58: 52-61. PMID 28866241 DOI: 10.1016/j.dnarep.2017.08.008 |
0.513 |
|
| 2017 |
Breslin C, Mani RS, Fanta M, Hoch N, Weinfeld M, Caldecott KW. The RIR motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair. The Journal of Biological Chemistry. PMID 28821613 DOI: 10.1074/Jbc.M117.806638 |
0.397 |
|
| 2017 |
Gómez-Herreros F, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW. TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription. Nature Communications. 8: 233. PMID 28794467 DOI: 10.1038/s41467-017-00307-y |
0.426 |
|
| 2016 |
Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD, ... ... Caldecott KW, et al. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. PMID 28002403 DOI: 10.1038/Nature20790 |
0.424 |
|
| 2016 |
Hanzlikova H, Gittens W, Krejcikova K, Zeng Z, Caldecott KW. Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin. Nucleic Acids Research. PMID 27965414 DOI: 10.1093/Nar/Gkw1246 |
0.452 |
|
| 2016 |
Grundy GJ, Polo LM, Zeng Z, Rulten SL, Hoch NC, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, Caldecott KW. PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). Nature Communications. 7: 12404. PMID 27530147 DOI: 10.1038/ncomms12404 |
0.498 |
|
| 2016 |
Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, ... Caldecott KW, et al. Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. The Biochemical Journal. PMID 27099339 DOI: 10.1042/BCJ20160180 |
0.426 |
|
| 2015 |
Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL. Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections. Mbio. 7. PMID 26715620 DOI: 10.1128/Mbio.01931-15 |
0.313 |
|
| 2015 |
Cherry AL, Nott TJ, Kelly G, Rulten SL, Caldecott KW, Smerdon SJ. Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains. Dna Repair. 35: 116-125. PMID 26519825 DOI: 10.1016/j.dnarep.2015.10.002 |
0.373 |
|
| 2015 |
Breslin C, Hornyak P, Ridley A, Rulten SL, Hanzlikova H, Oliver AW, Caldecott KW. The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function. Nucleic Acids Research. 43: 6934-44. PMID 26130715 DOI: 10.1093/nar/gkv623 |
0.492 |
|
| 2015 |
Cui X, McAllister R, Boregowda R, Sohn JA, Ledesma FC, Caldecott KW, Seeger C, Hu J. Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair? Plos One. 10: e0128401. PMID 26079492 DOI: 10.1371/Journal.Pone.0128401 |
0.563 |
|
| 2014 |
Caldecott KW. DNA single-strand break repair. Experimental Cell Research. 329: 2-8. PMID 25176342 DOI: 10.1016/j.yexcr.2014.08.027 |
0.572 |
|
| 2014 |
Caldecott KW. Protein ADP-ribosylation and the cellular response to DNA strand breaks. Dna Repair. 19: 108-13. PMID 24755000 DOI: 10.1016/j.dnarep.2014.03.021 |
0.59 |
|
| 2014 |
Grundy GJ, Moulding HA, Caldecott KW, Rulten SL. One ring to bring them all--the role of Ku in mammalian non-homologous end joining. Dna Repair. 17: 30-8. PMID 24680220 DOI: 10.1016/j.dnarep.2014.02.019 |
0.531 |
|
| 2014 |
Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, ... ... Caldecott KW, et al. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nature Genetics. 46: 516-21. PMID 24658003 DOI: 10.1038/ng.2929 |
0.364 |
|
| 2014 |
Caldecott KW. Molecular biology. Ribose--an internal threat to DNA. Science (New York, N.Y.). 343: 260-1. PMID 24436412 DOI: 10.1126/science.1248234 |
0.476 |
|
| 2014 |
Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW. PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Research. 42: 307-14. PMID 24049082 DOI: 10.1093/nar/gkt835 |
0.431 |
|
| 2013 |
Rulten SL, Caldecott KW. DNA strand break repair and neurodegeneration. Dna Repair. 12: 558-67. PMID 23712058 DOI: 10.1016/j.dnarep.2013.04.008 |
0.414 |
|
| 2013 |
Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. Plos Genetics. 9: e1003226. PMID 23505375 DOI: 10.1371/journal.pgen.1003226 |
0.47 |
|
| 2013 |
Thomson G, Watson A, Caldecott K, Denneny O, Depledge P, Hamilton N, Hopkins G, Jordan A, Morrow C, Raoof A, Waddell I, Ogilvie D. Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase. Analytical Biochemistry. 436: 145-50. PMID 23416181 DOI: 10.1016/J.Ab.2013.02.001 |
0.616 |
|
| 2013 |
Grundy GJ, Rulten SL, Zeng Z, Arribas-Bosacoma R, Iles N, Manley K, Oliver A, Caldecott KW. APLF promotes the assembly and activity of non-homologous end joining protein complexes. The Embo Journal. 32: 112-25. PMID 23178593 DOI: 10.1038/emboj.2012.304 |
0.537 |
|
| 2012 |
Caldecott KW. Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose. Nature Structural & Molecular Biology. 19: 1212-3. PMID 23211766 DOI: 10.1038/nsmb.2455 |
0.448 |
|
| 2012 |
Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1. Nucleic Acids Research. 40: 8371-80. PMID 22740648 DOI: 10.1093/nar/gks622 |
0.617 |
|
| 2012 |
Reynolds JJ, Walker AK, Gilmore EC, Walsh CA, Caldecott KW. Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair. Nucleic Acids Research. 40: 6608-19. PMID 22508754 DOI: 10.1093/Nar/Gks318 |
0.47 |
|
| 2011 |
Caldecott KW, Bohr VA, McKinnon PJ. 3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease". Mechanisms of Ageing and Development. 132: 353-4. PMID 21820005 DOI: 10.1016/j.mad.2011.07.006 |
0.403 |
|
| 2011 |
Rulten SL, Fisher AE, Robert I, Zuma MC, Rouleau M, Ju L, Poirier G, Reina-San-Martin B, Caldecott KW. PARP-3 and APLF function together to accelerate nonhomologous end-joining. Molecular Cell. 41: 33-45. PMID 21211721 DOI: 10.1016/j.molcel.2010.12.006 |
0.601 |
|
| 2011 |
Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage. The Journal of Biological Chemistry. 286: 403-9. PMID 21030584 DOI: 10.1074/jbc.M110.181016 |
0.577 |
|
| 2010 |
Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, ... Caldecott KW, et al. Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nature Genetics. 42: 245-9. PMID 20118933 DOI: 10.1038/Ng.526 |
0.439 |
|
| 2009 |
Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW. A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage. Nature. 461: 674-8. PMID 19794497 DOI: 10.1038/nature08444 |
0.577 |
|
| 2009 |
Dungey FA, Caldecott KW, Chalmers AJ. Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90. Molecular Cancer Therapeutics. 8: 2243-54. PMID 19671736 DOI: 10.1158/1535-7163.MCT-09-0201 |
0.338 |
|
| 2009 |
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nature Neuroscience. 12: 973-80. PMID 19633665 DOI: 10.1038/nn.2375 |
0.572 |
|
| 2009 |
Breslin C, Caldecott KW. DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress. Molecular and Cellular Biology. 29: 4653-62. PMID 19546231 DOI: 10.1128/MCB.00677-09 |
0.453 |
|
| 2009 |
Reynolds JJ, El-Khamisy SF, Caldecott KW. Short-patch single-strand break repair in ataxia oculomotor apraxia-1. Biochemical Society Transactions. 37: 577-81. PMID 19442253 DOI: 10.1042/BST0370577 |
0.585 |
|
| 2009 |
El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW. Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. Dna Repair. 8: 760-6. PMID 19303373 DOI: 10.1016/j.dnarep.2009.02.002 |
0.578 |
|
| 2009 |
Reynolds JJ, El-Khamisy SF, Katyal S, Clements P, McKinnon PJ, Caldecott KW. Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Molecular and Cellular Biology. 29: 1354-62. PMID 19103743 DOI: 10.1128/MCB.01471-08 |
0.577 |
|
| 2009 |
Caldecott KW. Chromosomal single-strand break repair The Dna Damage Response: Implications On Cancer Formation and Treatment. 261-284. DOI: 10.1007/978-90-481-2561-6_12 |
0.33 |
|
| 2008 |
Caldecott KW. Single-strand break repair and genetic disease. Nature Reviews. Genetics. 9: 619-31. PMID 18626472 DOI: 10.1038/nrg2380 |
0.534 |
|
| 2008 |
Caldecott KW. DNA damage responses and neurological disease. Preface. Dna Repair. 7: 1009. PMID 18515191 DOI: 10.1016/j.dnarep.2008.04.011 |
0.443 |
|
| 2008 |
Rulten SL, Cortes-Ledesma F, Guo L, Iles NJ, Caldecott KW. APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Molecular and Cellular Biology. 28: 4620-8. PMID 18474613 DOI: 10.1128/MCB.02243-07 |
0.397 |
|
| 2008 |
Petermann E, Helleday T, Caldecott KW. Claspin promotes normal replication fork rates in human cells. Molecular Biology of the Cell. 19: 2373-8. PMID 18353973 DOI: 10.1091/mbc.E07-10-1035 |
0.372 |
|
| 2008 |
Iles N, Rulten S, El-Khamisy SF, Caldecott KW. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks (Molecular and Cellular Biology (2007) 27, 10, (3793-3803)) Molecular and Cellular Biology. 28: 3561. DOI: 10.1128/MCB.00452-08 |
0.429 |
|
| 2007 |
Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ. TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. The Embo Journal. 26: 4720-31. PMID 17914460 DOI: 10.1038/sj.emboj.7601869 |
0.534 |
|
| 2007 |
McKinnon PJ, Caldecott KW. DNA strand break repair and human genetic disease. Annual Review of Genomics and Human Genetics. 8: 37-55. PMID 17887919 DOI: 10.1146/annurev.genom.7.080505.115648 |
0.568 |
|
| 2007 |
Mani RS, Fanta M, Karimi-Busheri F, Silver E, Virgen CA, Caldecott KW, Cass CE, Weinfeld M. XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. The Journal of Biological Chemistry. 282: 28004-13. PMID 17650498 DOI: 10.1074/jbc.M704867200 |
0.505 |
|
| 2007 |
Moser J, Kool H, Giakzidis I, Caldecott K, Mullenders LH, Fousteri MI. Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Molecular Cell. 27: 311-23. PMID 17643379 DOI: 10.1016/J.Molcel.2007.06.014 |
0.629 |
|
| 2007 |
El-Khamisy SF, Hartsuiker E, Caldecott KW. TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks. Dna Repair. 6: 1485-95. PMID 17600775 DOI: 10.1016/j.dnarep.2007.04.015 |
0.602 |
|
| 2007 |
Fisher AE, Hochegger H, Takeda S, Caldecott KW. Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Molecular and Cellular Biology. 27: 5597-605. PMID 17548475 DOI: 10.1128/MCB.02248-06 |
0.344 |
|
| 2007 |
Maya-Mendoza A, Petermann E, Gillespie DA, Caldecott KW, Jackson DA. Chk1 regulates the density of active replication origins during the vertebrate S phase. The Embo Journal. 26: 2719-31. PMID 17491592 DOI: 10.1038/sj.emboj.7601714 |
0.311 |
|
| 2007 |
Iles N, Rulten S, El-Khamisy SF, Caldecott KW. APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. Molecular and Cellular Biology. 27: 3793-803. PMID 17353262 DOI: 10.1128/MCB.02269-06 |
0.536 |
|
| 2007 |
Caldecott KW. Mammalian single-strand break repair: mechanisms and links with chromatin. Dna Repair. 6: 443-53. PMID 17118715 DOI: 10.1016/j.dnarep.2006.10.006 |
0.564 |
|
| 2007 |
el-Khamisy SF, Caldecott KW. DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1. Neuroscience. 145: 1260-6. PMID 17045754 DOI: 10.1016/j.neuroscience.2006.08.048 |
0.546 |
|
| 2006 |
Petermann E, Caldecott KW. Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase. Cell Cycle (Georgetown, Tex.). 5: 2203-9. PMID 16969104 |
0.45 |
|
| 2006 |
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature. 443: 713-6. PMID 16964241 DOI: 10.1038/Nature05164 |
0.6 |
|
| 2006 |
Breslin C, Clements PM, El-Khamisy SF, Petermann E, Iles N, Caldecott KW. Measurement of chromosomal DNA single-strand breaks and replication fork progression rates. Methods in Enzymology. 409: 410-25. PMID 16793415 DOI: 10.1016/S0076-6879(05)09024-5 |
0.48 |
|
| 2006 |
El-Khamisy SF, Caldecott KW. TDP1-dependent DNA single-strand break repair and neurodegeneration. Mutagenesis. 21: 219-24. PMID 16775218 DOI: 10.1093/mutage/gel024 |
0.524 |
|
| 2006 |
Petermann E, Maya-Mendoza A, Zachos G, Gillespie DA, Jackson DA, Caldecott KW. Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase. Molecular and Cellular Biology. 26: 3319-26. PMID 16581803 DOI: 10.1128/MCB.26.8.3319-3326.2006 |
0.417 |
|
| 2005 |
El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR, Caldecott KW. Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature. 434: 108-13. PMID 15744309 DOI: 10.1038/Nature03314 |
0.553 |
|
| 2004 |
Mani RS, Karimi-Busheri F, Fanta M, Caldecott KW, Cass CE, Weinfeld M. Biophysical characterization of human XRCC1 and its binding to damaged and undamaged DNA. Biochemistry. 43: 16505-14. PMID 15610045 DOI: 10.1021/bi048615m |
0.411 |
|
| 2004 |
Clements PM, Breslin C, Deeks ED, Byrd PJ, Ju L, Bieganowski P, Brenner C, Moreira MC, Taylor AM, Caldecott KW. The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. Dna Repair. 3: 1493-502. PMID 15380105 DOI: 10.1016/J.Dnarep.2004.06.017 |
0.562 |
|
| 2004 |
Caldecott KW. DNA single-strand breaks and neurodegeneration. Dna Repair. 3: 875-82. PMID 15279772 DOI: 10.1016/j.dnarep.2004.04.011 |
0.554 |
|
| 2004 |
Dianova II, Sleeth KM, Allinson SL, Parsons JL, Breslin C, Caldecott KW, Dianov GL. XRCC1-DNA polymerase beta interaction is required for efficient base excision repair. Nucleic Acids Research. 32: 2550-5. PMID 15141024 DOI: 10.1093/nar/gkh567 |
0.521 |
|
| 2004 |
Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW. The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. Cell. 117: 17-28. PMID 15066279 DOI: 10.1016/S0092-8674(04)00206-5 |
0.481 |
|
| 2003 |
El-Khamisy SF, Masutani M, Suzuki H, Caldecott KW. A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Research. 31: 5526-33. PMID 14500814 DOI: 10.1093/nar/gkg761 |
0.543 |
|
| 2003 |
Plo I, Liao ZY, Barceló JM, Kohlhagen G, Caldecott KW, Weinfeld M, Pommier Y. Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions. Dna Repair. 2: 1087-100. PMID 13679147 DOI: 10.1016/S1568-7864(03)00116-2 |
0.622 |
|
| 2003 |
Caldecott KW. XRCC1 and DNA strand break repair. Dna Repair. 2: 955-69. PMID 12967653 DOI: 10.1016/S1568-7864(03)00118-6 |
0.544 |
|
| 2003 |
Nakamura J, Asakura S, Hester SD, de Murcia G, Caldecott KW, Swenberg JA. Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time. Nucleic Acids Research. 31: e104. PMID 12930978 DOI: 10.1093/Nar/Gng105 |
0.434 |
|
| 2003 |
Okano S, Lan L, Caldecott KW, Mori T, Yasui A. Spatial and temporal cellular responses to single-strand breaks in human cells. Molecular and Cellular Biology. 23: 3974-81. PMID 12748298 DOI: 10.1128/MCB.23.11.3974-3981.2003 |
0.489 |
|
| 2003 |
Henry-Mowatt J, Jackson D, Masson JY, Johnson PA, Clements PM, Benson FE, Thompson LH, Takeda S, West SC, Caldecott KW. XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Molecular Cell. 11: 1109-17. PMID 12718895 DOI: 10.1016/S1097-2765(03)00132-1 |
0.45 |
|
| 2003 |
Caldecott KW. Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions. 31: 247-51. PMID 12546695 DOI: 10.1042/Bst0310247 |
0.527 |
|
| 2003 |
Caldecott KW. DNA single-strand break repair and spinocerebellar ataxia. Cell. 112: 7-10. PMID 12526788 DOI: 10.1016/S0092-8674(02)01247-3 |
0.511 |
|
| 2002 |
Iftner T, Elbel M, Schopp B, Hiller T, Loizou JI, Caldecott KW, Stubenrauch F. Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1. The Embo Journal. 21: 4741-8. PMID 12198176 DOI: 10.1093/emboj/cdf443 |
0.549 |
|
| 2002 |
Taylor RM, Thistlethwaite A, Caldecott KW. Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair. Molecular and Cellular Biology. 22: 2556-63. PMID 11909950 DOI: 10.1128/MCB.22.8.2556-2563.2002 |
0.407 |
|
| 2001 |
Caldecott KW. Mammalian DNA single-strand break repair: an X-ra(y)ted affair. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 23: 447-55. PMID 11340626 DOI: 10.1002/bies.1063 |
0.562 |
|
| 2001 |
Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell. 104: 107-17. PMID 11163244 DOI: 10.1016/S0092-8674(01)00195-7 |
0.588 |
|
| 2000 |
Bogliolo M, Taylor RM, Caldecott KW, Frosina G. Reduced ligation during DNA base excision repair supported by BRCA2 mutant cells. Oncogene. 19: 5781-7. PMID 11126365 DOI: 10.1038/sj.onc.1203951 |
0.586 |
|
| 2000 |
Moore DJ, Taylor RM, Clements P, Caldecott KW. Mutation of a BRCT domain selectively disrupts DNA single-strand break repair in noncycling Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 13649-54. PMID 11095742 DOI: 10.1073/pnas.250477597 |
0.565 |
|
| 2000 |
Taylor RM, Whitehouse CJ, Caldecott KW. The DNA ligase III zinc finger stimulates binding to DNA secondary structure and promotes end joining. Nucleic Acids Research. 28: 3558-63. PMID 10982876 |
0.501 |
|
| 2000 |
Johnson PA, Clements P, Hudson K, Caldecott KW. The mitotic spindle and DNA damage-induced apoptosis. Toxicology Letters. 112: 59-67. PMID 10720713 DOI: 10.1016/S0378-4274(99)00245-3 |
0.476 |
|
| 2000 |
Taylor RM, Moore DJ, Whitehouse J, Johnson P, Caldecott KW. A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair. Molecular and Cellular Biology. 20: 735-40. PMID 10611252 DOI: 10.1128/MCB.20.2.735-740.2000 |
0.558 |
|
| 1999 |
Johnson PA, Clements P, Hudson K, Caldecott KW. A mitotic spindle requirement for DNA damage-induced apoptosis in Chinese hamster ovary cells. Cancer Research. 59: 2696-700. PMID 10363994 |
0.542 |
|
| 1998 |
Taylor RM, Whitehouse J, Cappelli E, Frosina G, Caldecott KW. Role of the DNA ligase III zinc finger in polynucleotide binding and ligation. Nucleic Acids Research. 26: 4804-10. PMID 9776738 DOI: 10.1093/nar/26.21.4804 |
0.542 |
|
| 1998 |
Taylor RM, Wickstead B, Cronin S, Caldecott KW. Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1. Current Biology : Cb. 8: 877-80. PMID 9705932 |
0.446 |
|
| 1997 |
Cappelli E, Taylor R, Cevasco M, Abbondandolo A, Caldecott K, Frosina G. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. The Journal of Biological Chemistry. 272: 23970-5. PMID 9295348 DOI: 10.1074/Jbc.272.38.23970 |
0.612 |
|
| 1997 |
Nash RA, Caldecott KW, Barnes DE, Lindahl T. XRCC1 protein interacts with one of two distinct forms of DNA ligase III. Biochemistry. 36: 5207-11. PMID 9136882 DOI: 10.1021/Bi962281M |
0.62 |
|
| 1997 |
Cappelli E, Taylor R, Cevasco M, Abbondandolo A, Caldecott K, Frosina G. P IV.7b Defective ligation of base excision repair patches in XRCC1 mutant cells Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S30. DOI: 10.1016/S0027-5107(97)82692-9 |
0.398 |
|
| 1997 |
Taylor R, Caldecott K. P IV.4 Biochemical characterisation of the XRCC1/DNA ligase III human protein complex Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S29. DOI: 10.1016/S0027-5107(97)82688-7 |
0.505 |
|
| 1996 |
Caldecott KW, Aoufouchi S, Johnson P, Shall S. XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro. Nucleic Acids Research. 24: 4387-94. PMID 8948628 DOI: 10.1093/nar/24.22.4387 |
0.559 |
|
| 1995 |
Caldecott KW, Tucker JD, Stanker LH, Thompson LH. Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Research. 23: 4836-43. PMID 8532526 DOI: 10.1093/nar/23.23.4836 |
0.623 |
|
| 1995 |
Wei YF, Robins P, Carter K, Caldecott K, Pappin DJ, Yu GL, Wang RP, Shell BK, Nash RA, Schär P. Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Molecular and Cellular Biology. 15: 3206-16. PMID 7760816 |
0.563 |
|
| 1994 |
Caldecott KW, McKeown CK, Tucker JD, Ljungquist S, Thompson LH. An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Molecular and Cellular Biology. 14: 68-76. PMID 8264637 |
0.613 |
|
| 1994 |
Caldecott KW, Thompson LH. Partial correction of the single-strand break repair defect in the CHO mutant EM9 by electroporated recombinant XRCC1 protein. Annals of the New York Academy of Sciences. 726: 336-9. PMID 8092698 |
0.405 |
|
| 1993 |
Caldecott K, Banks G, Jeggo P. The induction and reversal of topoisomerase II cleavable complexes formed by nuclear extract from the CHO DNA repair mutant, xrs1. Mutation Research. 293: 259-67. PMID 7679476 DOI: 10.1016/0921-8777(93)90077-T |
0.61 |
|
| 1992 |
Caldecott KW, Tucker JD, Thompson LH. Construction of human XRCC1 minigenes that fully correct the CHO DNA repair mutant EM9. Nucleic Acids Research. 20: 4575-9. PMID 1408759 DOI: 10.1093/nar/20.17.4575 |
0.5 |
|
| 1991 |
Caldecott K, Jeggo P. Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutation Research. 255: 111-21. PMID 1922147 DOI: 10.1016/0921-8777(91)90046-R |
0.612 |
|
| 1990 |
Caldecott K, Banks G, Jeggo P. DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II. Cancer Research. 50: 5778-83. PMID 2168280 |
0.478 |
|
| 1989 |
Jeggo PA, Caldecott K, Pidsley S, Banks GR. Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors. Cancer Research. 49: 7057-63. PMID 2479475 |
0.596 |
|
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