Troy S. Gates, MD - Related publications

Affiliations: 
Otolaryngology Johns Hopkins University, Baltimore, MD 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Kukkonen JP. Allosteric interactions via the orthosteric ligand binding sites in a constitutive G-protein-coupled receptor homodimer. Pharmacological Research. 105116. PMID 32783977 DOI: 10.1016/j.phrs.2020.105116   
2020 Li Y, Coons LA, Houtman R, Carlson KE, Martin TA, Mayne CG, Melchers D, Jefferson TB, Ramsey JT, Katzenellenbogen JA, Korach KS. A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment. Science Signaling. 13. PMID 32963012 DOI: 10.1126/scisignal.aaw4653   
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA Receptor: Relating Occupancy to State Functions. Molecular Pharmacology. 98: 303-313. PMID 32873746 DOI: 10.1124/molpharm.120.000066   
2020 Yang JF, Williams AH, Penthala NR, Prather PL, Crooks PA, Zhan CG. Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands. Acs Chemical Neuroscience. PMID 32997485 DOI: 10.1021/acschemneuro.0c00551   
2020 Jakubík J, Randáková A, Chetverikov N, El-Fakahany EE, Doležal V. The operational model of allosteric modulation of pharmacological agonism. Scientific Reports. 10: 14421. PMID 32879329 DOI: 10.1038/s41598-020-71228-y   
2020 Feng Z, Liang T, Wang S, Chen M, Hou T, Zhao J, Chen H, Zhou Y, Xie XQ. Binding Characterization of GPCRs-Modulator by Molecular Complex Characterizing System (MCCS). Acs Chemical Neuroscience. PMID 32941011 DOI: 10.1021/acschemneuro.0c00457   
2020 Singh N, Villoutreix BO. Demystifying the Molecular Basis of Pyrazoloquinolinones Recognition at the Extracellular α1+/β3- Interface of the GABA Receptor by Molecular Modeling. Frontiers in Pharmacology. 11: 561834. PMID 33041802 DOI: 10.3389/fphar.2020.561834   
2020 Christensen SC, Krogh BO, Jensen A, Andersen CBF, Christensen S, Nielsen MS. Characterization of basigin monoclonal antibodies for receptor-mediated drug delivery to the brain. Scientific Reports. 10: 14582. PMID 32884039 DOI: 10.1038/s41598-020-71286-2   
2020 Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 30: 127501. PMID 32882418 DOI: 10.1016/j.bmcl.2020.127501   
2020 Joshi N, Kumar D, Poluri KM. Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. Acs Omega. 5: 22637-22651. PMID 32923824 DOI: 10.1021/acsomega.0c03428   
2020 Harms M, Gilg A, Ständker L, Beer AJ, Mayer B, Rasche V, Gruber CW, Münch J. Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Scientific Reports. 10: 16036. PMID 32994431 DOI: 10.1038/s41598-020-73012-4   
2020 Wang L, DeRose PC, Inwood SL, Gaigalas AK. Stochastic Reaction-Diffusion Model of the Binding of Monoclonal Antibodies to CD4 Receptors on the Surface of T Cells. International Journal of Molecular Sciences. 21. PMID 32846978 DOI: 10.3390/ijms21176086   
2020 Bernhard M, Laube B. Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs. Scientific Reports. 10: 16569. PMID 33024136 DOI: 10.1038/s41598-020-73157-2   
2020 Turk LS, Mitchell D, Comoletti D. Purification of a heterodimeric Reelin construct to investigate binding stoichiometry. European Biophysics Journal : Ebj. PMID 33057791 DOI: 10.1007/s00249-020-01465-6   
2020 Peri SSS, Sabnani MK, Raza MU, Urquhart EL, Ghaffari S, Lee J, Kim M, Weidanz JA, Alexandrakis G. Quantification of Low Affinity Binding Interactions between Natural Killer Cell Inhibitory Receptors and Targeting Ligands with a Self-Induced Back-Action Actuated Nanopore Electrophoresis (SANE) Sensor. Nanotechnology. PMID 33027774 DOI: 10.1088/1361-6528/abbf26   
2020 Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS. Site-specific effects of neurosteroids on GABA receptor activation and desensitization. Elife. 9. PMID 32955433 DOI: 10.7554/eLife.55331   
2020 Gasperotti AF, Karina Herrera Seitz M, Balmaceda RS, Prosa LM, Jung K, Studdert CA. Direct binding of benzoate derivatives to two chemoreceptors with Cache sensor domains in Halomonas titanicae KHS3. Molecular Microbiology. PMID 33098326 DOI: 10.1111/mmi.14630   
2020 Antonopoulos A, Broome S, Sharov V, Ziegenfuss C, Easton RL, Panico M, Dell A, Morris HR, Haslam SM. Site-specific characterisation of SARS-CoV-2 spike glycoprotein receptor binding domain. Glycobiology. PMID 32886791 DOI: 10.1093/glycob/cwaa085   
2020 Pieterse L, van der Walt MM, Terre'Blanche G. C2-substituted quinazolinone derivatives exhibit A and/or A adenosine receptor affinities in the low micromolar range. Bioorganic & Medicinal Chemistry Letters. 30: 127274. PMID 32631506 DOI: 10.1016/j.bmcl.2020.127274   
2020 Shewell LK, Day CJ, Jen FE, Haselhorst T, Atack JM, Reijneveld JF, Everest-Dass A, James DBA, Boguslawski KM, Brouwer S, Gillen CM, Luo Z, Kobe B, Nizet V, von Itzstein M, et al. All major cholesterol-dependent cytolysins use glycans as cellular receptors. Science Advances. 6. PMID 32937333 DOI: 10.1126/sciadv.aaz4926   
2020 de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicology in Vitro : An International Journal Published in Association With Bibra. 104975. PMID 32858110 DOI: 10.1016/j.tiv.2020.104975   
2020 Ott J, Spilhaug MM, Maschauer S, Rafique W, Jakobsson JE, Hartvig K, Hübner H, Gmeiner P, Prante O, Riss PJ. Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with F-Labeled Derivatives in Rats. Journal of Medicinal Chemistry. 63: 9484-9499. PMID 32787100 DOI: 10.1021/acs.jmedchem.0c00683   
2020 Williams CA, Miller KE, Williams NP, Portfors CV, Perkel DJ. Distribution and co-expression of adrenergic receptor-encoding mRNA in the mouse inferior colliculus. The Journal of Comparative Neurology. PMID 33067825 DOI: 10.1002/cne.25053   
2020 Wu Z, Newstead S, Biggin PC. The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond. Scientific Reports. 10: 16903. PMID 33037300 DOI: 10.1038/s41598-020-73906-3   
2020 Norel X, Sugimoto Y, Ozen G, Abdelazeem H, Amgoud Y, Bouhadoun A, Bassiouni W, Goepp M, Mani S, Manikpurage HD, Senbel A, Longrois D, Heinemann A, Yao C, Clapp LH. International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions. Pharmacological Reviews. 72: 910-968. PMID 32962984 DOI: 10.1124/pr.120.019331   
2020 Szőke É, Bálint M, Hetényi C, Markovics A, Elekes K, Pozsgai G, Szűts T, Kéri G, Őrfi L, Sándor Z, Szolcsányi J, Pintér E, Helyes Z. Small molecule somatostatin receptor subtype 4 (sst) agonists are novel anti-inflammatory and analgesic drug candidates. Neuropharmacology. 178: 108198. PMID 32739276 DOI: 10.1016/j.neuropharm.2020.108198   
2020 Hodolic M, Wu WY, Zhao Z, Yu F, Virgolini I, Wang F. Safety and tolerability of Ga-NT-20.3, a radiopharmaceutical for targeting neurotensin receptors, in patients with pancreatic ductal adenocarcinoma: the first in-human use. European Journal of Nuclear Medicine and Molecular Imaging. PMID 33006657 DOI: 10.1007/s00259-020-05045-w   
2020 Kober DL, Stuchell-Brereton MD, Kluender CE, Dean HB, Strickland MR, Steinberg DF, Nelson SS, Baban B, Holtzman DM, Frieden C, Alexander-Brett J, Roberson ED, Song Y, Brett TJ. Functional insights from biophysical study of TREM2 interactions with apoE and Aβ. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33090700 DOI: 10.1002/alz.12194   
2020 Frost M, Keable A, Baseley D, Sealy A, Andreea Zbarcea D, Gatherer M, Yuen HM, Sharp MM, Weller RO, Attems J, Smith C, Chiarot PR, Carare RO. Vascular α1A Adrenergic Receptors as a Potential Therapeutic Target for IPAD in Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). 13. PMID 32971843 DOI: 10.3390/ph13090261   
2020 Li Z, Luo W, Fang S, Chen X, Lin T, Zhou S, Zhang L, Yang W, Li Z, Jiantao Y, Junjian W, Liu P, Li Z. Prostacyclin facilitates vascular smooth muscle cell phenotypic transformation via activating TP receptors when IP receptors are deficient. Acta Physiologica (Oxford, England). e13555. PMID 32886850 DOI: 10.1111/apha.13555   
2020 Moritz AE, Bonifazi A, Guerrero AM, Kumar V, Free RB, Lane JR, Verma RK, Shi L, Newman AH, Sibley DR. Evidence for a stereoselective mechanism for bitopic activity by extended-length antagonists of the D3 dopamine receptor. Acs Chemical Neuroscience. PMID 32969645 DOI: 10.1021/acschemneuro.0c00425   
2020 Ellaithy A, Gonzalez-Maeso J, Logothetis DA, Levitz J. Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in Biochemical Sciences. PMID 32861513 DOI: 10.1016/j.tibs.2020.07.008   
2020 Waltenspühl Y, Schöppe J, Ehrenmann J, Kummer L, Plückthun A. Crystal structure of the human oxytocin receptor. Science Advances. 6: eabb5419. PMID 32832646 DOI: 10.1126/sciadv.abb5419   
2020 Xiao S, Xie W, Zhou L. Mucosal chemokine CXCL17: What is known and not known. Scandinavian Journal of Immunology. e12965. PMID 32869346 DOI: 10.1111/sji.12965   
2020 Shi JJ, Jia KH, Sun H, Gunosewoyo H, Yang F, Tang J, Luo J, Yu L. Synthesis and pharmacological evaluation of σ2 receptor ligands based on a 3-alkoxyisoxazole scaffold: potential antitumor effects against osteosarcoma. Chemmedchem. PMID 32964625 DOI: 10.1002/cmdc.202000461   
2020 Grosicki M, Adami M, Micheloni C, Głuch-Lutwin M, Siwek A, Latacz G, Łażewska D, Więcek M, Reiner D, Stark H, Chlopicki S, Kieć-Kononowicz K. Eosinophils adhesion assay as a tool for phenotypic drug screening - The pharmacology of 1,3,5 - Triazine and 1h-indole like derivatives against the human histamine H receptor. European Journal of Pharmacology. 173611. PMID 33017589 DOI: 10.1016/j.ejphar.2020.173611   
2020 Davies JR, Masuyer G, Stenmark P. Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors. Toxins. 12. PMID 32957706 DOI: 10.3390/toxins12090603   
2020 Vunnam N, Szymonski S, Hirsova P, Gores G, Sachs JN, Hackel BJ. Noncompetitive allosteric antagonism of death receptor 5 by a synthetic affibody ligand. Biochemistry. PMID 32941010 DOI: 10.1021/acs.biochem.0c00529   
2020 Yeliseev A, van den Berg A, Zoubak L, Hines K, Stepnowski S, Williston K, Yan W, Gawrisch K, Zmuda J. Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture. Scientific Reports. 10: 16805. PMID 33033368 DOI: 10.1038/s41598-020-73813-7   
2020 Hessman CL, Hildebrandt J, Shah A, Brandt S, Bock A, Frye BC, Raffetseder U, Geffers R, Brunner-Weinzierl MC, Isermann B, Mertens PR, Lindquist JA. YB-1 Interferes with TNFα-TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling. International Journal of Molecular Sciences. 21. PMID 32992926 DOI: 10.3390/ijms21197076   
2020 Li G, Nieman AN, Mian MY, Zahn NM, Mikulsky BN, Poe MM, Methuku KR, Liu Y, Cook JM, Stafford DC, Arnold LA. A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA Receptor. Molecules (Basel, Switzerland). 25. PMID 32854311 DOI: 10.3390/molecules25173864   
2020 Andrejew R, Oliveira-Giacomelli Á, Ribeiro DE, Glaser T, Arnaud-Sampaio VF, Lameu C, Ulrich H. The P2X7 Receptor: Central Hub of Brain Diseases. Frontiers in Molecular Neuroscience. 13: 124. PMID 32848594 DOI: 10.3389/fnmol.2020.00124   
2020 Gunera J, Baker JG, van Hilten N, Rosenbaum DM, Kolb P. Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. Journal of Medicinal Chemistry. PMID 32977721 DOI: 10.1021/acs.jmedchem.0c00964   
2020 Yu B, Cheng C, Wu Y, Guo L, Kong D, Zhang Z, Wang Y, Zheng E, Liu Y, He Y. Interactions of ferritin with scavenger receptor class A members. The Journal of Biological Chemistry. PMID 32907880 DOI: 10.1074/jbc.RA120.014690   
2020 Ricart-Ortega M, Berizzi AE, Pereira V, Malhaire F, Catena J, Font J, Gómez-Santacana X, Muñoz L, Zussy C, Serra C, Rovira X, Goudet C, Llebaria A. Mechanistic Insights into Light-Driven Allosteric Control of GPCR Biological Activity. Acs Pharmacology & Translational Science. 3: 883-895. PMID 33073188 DOI: 10.1021/acsptsci.0c00054   
2020 Lyons EL, Leone-Kabler S, Kovach AL, Thomas BF, Howlett AC. Cannabinoid receptor subtype influence on neuritogenesis in human SH-SY5Y cells. Molecular and Cellular Neurosciences. 103566. PMID 33049367 DOI: 10.1016/j.mcn.2020.103566   
2020 Gao S, Chen S, Han D, Wang Z, Li M, Han W, Besschetnova A, Liu M, Zhou F, Barrett D, Luong MP, Owiredu J, Liang Y, Ahmed M, Petricca J, et al. Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer. Nature Genetics. PMID 32868907 DOI: 10.1038/s41588-020-0681-7   
2020 Barrett JA, Choi J, Lakshmikanthan S, Kim YY, Greene D, Kolli P, Song TH, Choi IY, Kim YH, Lebel F. Eflapegrastim Enhanced Efficacy Compared to Pegfilgrastim in Neutropenic Rats Supports Potential for Same-Day Dosing. Experimental Hematology. PMID 33002567 DOI: 10.1016/j.exphem.2020.09.199   
2020 Pollok S, Reiner A. Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization. Proceedings of the National Academy of Sciences of the United States of America. 117: 25851-25858. PMID 32999066 DOI: 10.1073/pnas.2007471117   
2020 Butenas ALE, Rollins KS, Matney JE, Williams AC, Kleweno TE, Parr SK, Hammond ST, Ade CJ, Hageman KS, Musch TI, Copp SW. No effect of endoperoxide 4 or thromboxane A receptor blockade on static mechanoreflex activation in rats with heart failure. Experimental Physiology. PMID 32954541 DOI: 10.1113/EP088835