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Gary Strichartz - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Persistent pain, Molecular and Cellular Mechanism
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75/268 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Garibyan L, Moradi Tuchayi S, Wang Y, Khodorova A, Stemmer-Rachamimov A, Purschke M, Osseiran S, Evans CL, Mao J, Strichartz G, Anderson RR. Neural Selective Cryoneurolysis with Ice Slurry Injection in a Rat Model. Anesthesiology. PMID 31977524 DOI: 10.1097/Aln.0000000000003124  0.361
2019 Zinboonyahgoon N, Vlassakov K, Lirk P, Spivey T, King T, Dominici L, Golshan M, Strichartz G, Edwards R, Schreiber K. Benefit of regional anaesthesia on postoperative pain following mastectomy: the influence of catastrophising. British Journal of Anaesthesia. 123: e293-e302. PMID 31331591 DOI: 10.1016/J.Bja.2019.01.041  0.305
2018 Khodorova A, Zhang Y, Nicol G, Strichartz G. Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain. Physiological Research. 67: S215-S225. PMID 29947541 DOI: 10.33549/PHYSIOLRES.933819  0.36
2017 Kays J, Zhang YH, Khorodova A, Strichartz G, Nicol GD. Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor. Neuroscience. PMID 29288797 DOI: 10.1016/j.neuroscience.2017.12.030  0.347
2017 Lirk P, Hollmann MW, Strichartz G. The Science of Local Anesthesia: Basic Research, Clinical Application, and Future Directions. Anesthesia and Analgesia. PMID 29189280 DOI: 10.1213/ANE.0000000000002665  0.407
2016 Khodorova A, Nicol GD, Strichartz G. The TrkA receptor mediates experimental thermal hyperalgesia produced by nerve growth factor: Modulation by the p75 neurotrophin receptor. Neuroscience. PMID 27826102 DOI: 10.1016/j.neuroscience.2016.10.064  0.304
2013 Khodorova A, Nicol GD, Strichartz G. The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw. Neuroscience. 254: 312-23. PMID 24095693 DOI: 10.1016/j.neuroscience.2013.09.046  0.328
2013 Barreveld A, Witte J, Chahal H, Durieux ME, Strichartz G. Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesthesia and Analgesia. 116: 1141-61. PMID 23408672 DOI: 10.1213/ANE.0b013e318277a270  0.379
2013 Leeson S, Strichartz G. Kinetics of uptake and washout of lidocaine in rat sciatic nerve in vitro. Anesthesia and Analgesia. 116: 694-702. PMID 23400993 DOI: 10.1213/ANE.0b013e31827aed25  0.362
2013 Ganesh A, Montmayeur J, Strichartz G. Endothelin-1 nociceptive signaling in keratinocytes may involve sensitization of adenylate cyclase The Journal of Pain. 14: S42. DOI: 10.1016/j.jpain.2013.01.502  0.319
2012 Ohri R, Blaskovich P, Wang JC, Pham L, Nichols G, Hildebrand W, Costa D, Scarborough N, Herman C, Strichartz G. Prolonged nerve block by microencapsulated bupivacaine prevents acute postoperative pain in rats. Regional Anesthesia and Pain Medicine. 37: 607-15. PMID 22996201 DOI: 10.1097/Aap.0B013E3182680F35  0.39
2011 Ji RR, Xu ZZ, Strichartz G, Serhan CN. Emerging roles of resolvins in the resolution of inflammation and pain. Trends in Neurosciences. 34: 599-609. PMID 21963090 DOI: 10.1016/J.Tins.2011.08.005  0.316
2011 Colvin AC, Wang CF, Soens MA, Mitani AA, Strichartz G, Gerner P. Prolonged cutaneous analgesia with transdermal application of amitriptyline and capsaicin. Regional Anesthesia and Pain Medicine. 36: 236-40. PMID 21364497 DOI: 10.1097/AAP.0b013e31820c2c30  0.414
2011 Huang L, Wang CF, Serhan CN, Strichartz G. Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. Pain. 152: 557-65. PMID 21255928 DOI: 10.1016/J.Pain.2010.11.021  0.34
2011 Wang CF, Pancaro C, Gerner P, Strichartz G. Prolonged suppression of postincisional pain by a slow-release formulation of lidocaine. Anesthesiology. 114: 135-49. PMID 21169797 DOI: 10.1097/ALN.0b013e3182001996  0.383
2010 Gerner P, Wang CF, Lee BS, Suzuki S, Degirolami U, Gandhi A, Knaack D, Strichartz G. The relationship between functional sciatic nerve block duration and the rate of release of lidocaine from a controlled-release matrix. Anesthesia and Analgesia. 111: 221-9. PMID 20522702 DOI: 10.1213/ANE.0b013e3181dd2690  0.332
2009 Khodorova A, Zou S, Ren K, Dubner R, Davar G, Strichartz G. Dual Roles for Endothelin-B Receptors in Modulating Adjuvant-Induced Inflammatory Hyperalgesia in Rats. The Open Pain Journal. 2: 30-40. PMID 20559459 DOI: 10.2174/1876386300902010030  0.317
2009 Colucci V, Strichartz G, Jolesz F, Vykhodtseva N, Hynynen K. Focused ultrasound effects on nerve action potential in vitro. Ultrasound in Medicine & Biology. 35: 1737-47. PMID 19647923 DOI: 10.1016/J.Ultrasmedbio.2009.05.002  0.367
2009 Khodorova A, Richter J, Vasko MR, Strichartz G. Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1. The Journal of Pain : Official Journal of the American Pain Society. 10: 740-9. PMID 19559390 DOI: 10.1016/j.jpain.2009.01.265  0.307
2009 Feng B, Strichartz G. Endothelin-1 raises excitability and reduces potassium currents in sensory neurons. Brain Research Bulletin. 79: 345-50. PMID 19409452 DOI: 10.1016/j.brainresbull.2009.04.012  0.359
2009 Wang CF, Djalali AG, Gandhi A, Knaack D, De Girolami U, Strichartz G, Gerner P. An absorbable local anesthetic matrix provides several days of functional sciatic nerve blockade. Anesthesia and Analgesia. 108: 1027-33. PMID 19224820 DOI: 10.1213/ane.0b013e318193596a  0.351
2009 Hans G, Schmidt BL, Strichartz G. Nociceptive sensitization by endothelin-1. Brain Research Reviews. 60: 36-42. PMID 19150466 DOI: 10.1016/J.Brainresrev.2008.12.008  0.307
2009 Khodorova A, Montmayeur JP, Strichartz G. Endothelin receptors and pain. The Journal of Pain : Official Journal of the American Pain Society. 10: 4-28. PMID 19111868 DOI: 10.1016/j.jpain.2008.09.009  0.327
2008 Sugimoto K, Kissin I, Strichartz G. A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cells. Anesthesia and Analgesia. 107: 318-24. PMID 18635503 DOI: 10.1213/ane.0b013e31816d140a  0.385
2007 Yanagidate F, Strichartz GR. Local anesthetics. Handbook of Experimental Pharmacology. 95-127. PMID 17087121 DOI: 10.1007/978-3-540-33823-9_4  0.368
2007 Strichartz G. Sodium Channels, Pain, and Analgesia. Edited by Kevin Coward and Mark D. Baker. Chemmedchem. 2: 243-243. DOI: 10.1002/CMDC.200600210  0.364
2006 Amir R, Argoff CE, Bennett GJ, Cummins TR, Durieux ME, Gerner P, Gold MS, Porreca F, Strichartz GR. The role of sodium channels in chronic inflammatory and neuropathic pain. The Journal of Pain : Official Journal of the American Pain Society. 7: S1-29. PMID 16632328 DOI: 10.1016/J.Jpain.2006.01.444  0.328
2004 Ji RR, Strichartz G. Cell signaling and the genesis of neuropathic pain. Science's Stke : Signal Transduction Knowledge Environment. 2004: reE14. PMID 15454629 DOI: 10.1126/stke.2522004re14  0.349
2004 Houck CS, Khodorova A, Reale AM, Strichartz GR, Davar G. Sensory fibers resistant to the actions of tetrodotoxin mediate nocifensive responses to local administration of endothelin-1 in rats. Pain. 110: 719-26. PMID 15288413 DOI: 10.1016/j.pain.2004.05.012  0.302
2004 Son SL, Wong K, Strichartz G. Antagonism by local anesthetics of sodium channel activators in the presence of scorpion toxins: two mechanisms for competitive inhibition. Cellular and Molecular Neurobiology. 24: 565-77. PMID 15233379 DOI: 10.1023/B:CEMN.0000023630.16308.54  0.414
2002 Persaud N, Strichartz GR. Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin. Pain. 99: 333-40. PMID 12237212 DOI: 10.1016/S0304-3959(02)00163-X  0.354
2002 Nau C, Strichartz GR. Drug chirality in anesthesia. Anesthesiology. 97: 497-502. PMID 12151942 DOI: 10.1097/00000542-200208000-00029  0.44
2002 Zhou Z, Davar G, Strichartz G. Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6325-30. PMID 12151509 DOI: 10.1523/Jneurosci.22-15-06325.2002  0.359
2002 Strichartz GR, Zhou Z, Sinnott C, Khodorova A. Therapeutic concentrations of local anaesthetics unveil the potential role of sodium channels in neuropathic pain. Novartis Foundation Symposium. 241: 189-201; discussion . PMID 11771646  0.329
2001 Zhou QL, Strichartz G, Davar G. Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons. Neuroreport. 12: 3853-7. PMID 11726808 DOI: 10.1097/00001756-200112040-00050  0.322
2001 Khodorova A, Meissner K, Leeson S, Strichartz GR. Lidocaine selectively blocks abnormal impulses arising from noninactivating Na channels. Muscle & Nerve. 24: 634-47. PMID 11317273 DOI: 10.1002/mus.1049  0.35
2000 Nau C, Wang SY, Strichartz GR, Wang GK. Block of human heart hH1 sodium channels by the enantiomers of bupivacaine. Anesthesiology. 93: 1022-33. PMID 11020758 DOI: 10.1097/00000542-200010000-00026  0.56
2000 Vladimirov M, Nau C, Mok WM, Strichartz G. Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies. Anesthesiology. 93: 744-55. PMID 10969308 DOI: 10.1097/00000542-200009000-00024  0.62
1999 Nau C, Wang SY, Strichartz GR, Wang GK. Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers. Molecular Pharmacology. 56: 404-13. PMID 10419561  0.543
1999 Kohane DS, Kuang Y, Lu NT, Langer R, Strichartz GR, Berde CB. Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 90: 524-34. PMID 9952161 DOI: 10.1097/00000542-199902000-00029  0.33
1998 Chamberlain LJ, Yannas IV, Hsu HP, Strichartz G, Spector M. Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Experimental Neurology. 154: 315-29. PMID 9878170 DOI: 10.1006/Exnr.1998.6955  0.323
1998 Davar G, Hans G, Fareed MU, Sinnott C, Strichartz G. Behavioral signs of acute pain produced by application of endothelin-1 to rat sciatic nerve. Neuroreport. 9: 2279-83. PMID 9694215 DOI: 10.1097/00001756-199807130-00025  0.394
1998 Kohane DS, Yieh J, Lu NT, Langer R, Strichartz GR, Berde CB. A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 89: 119-31. PMID 9667302 DOI: 10.1097/00000542-199807000-00019  0.309
1998 Kohane DS, Kuang Y, Langer R, Strichartz GR, Berde CB. VANILLOIDS AND SITE 1 SODIUM CHANNEL TOXINS SYNERGISTICALLY BLOCK SCIATIC NERVE IN VIVO Anesthesiology. 89: 885A. DOI: 10.1097/00000542-199809150-00060  0.321
1998 Nau C, Strichartz GR. MEMBRANE POTENTIAL REVERSES STEREO-SELECTIVITY OF BUPIVACAINE ENANTIOMERS TO BLOCK SODIUM CURRENT IN RAT GH3 CELLS Anesthesiology. 89: 882A. DOI: 10.1097/00000542-199809150-00057  0.52
1997 Vladimirov M, Thalhammer JG, Hunt N, Feldman HS, Strichartz G. Neurophysiologic actions and neurological consequences of veratridine on the rat sciatic nerve. Anesthesiology. 86: 945-56. PMID 9105239 DOI: 10.1097/00000542-199704000-00025  0.354
1995 McHugh J, Mok WM, Wang GK, Strichartz G. Irreversible inhibition of sodium current and batrachotoxin binding by a photoaffinity-derivatized local anesthetic. The Journal of General Physiology. 105: 267-87. PMID 7760019 DOI: 10.1085/jgp.105.2.267  0.313
1995 Strichartz G. Protracted relief of experimental neuropathic pain by systemic local anesthetics. How, where, and when. Anesthesiology. 83: 654-5. PMID 7574043 DOI: 10.1097/00000542-199510000-00002  0.301
1993 Wilder RT, Berde CB, Griggs CT, Chickalingaiah R, Strichartz G. Chronic exposure to lidocaine does not alter flux through sodium channels in cultured neuronal cells. Regional Anesthesia. 18: 283-9. PMID 8268116 DOI: 10.1136/Rapm-00115550-199318050-00004  0.382
1992 Wood MR, DeBin J, Strichartz GR, Pfenninger KH. Plasmalemmal insertion and modification of sodium channels at the nerve growth cone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 2948-59. PMID 1322979 DOI: 10.1523/Jneurosci.12-08-02948.1992  0.402
1992 Lee-Son S, Wang GK, Concus A, Crill E, Strichartz G. Stereoselective inhibition of neuronal sodium channels by local anesthetics. Evidence for two sites of action? Anesthesiology. 77: 324-35. PMID 1322642 DOI: 10.1097/00000542-199208000-00016  0.429
1991 Schneider M, Datta S, Strichartz G. A preferential inhibition of impulses in C-fibers of the rabbit vagus nerve by veratridine, an activator of sodium channels. Anesthesiology. 74: 270-80. PMID 1846725 DOI: 10.1097/00000542-199102000-00013  0.396
1991 Drachman D, Strichartz G. Potassium channel blockers potentiate impulse inhibition by local anesthetics. Anesthesiology. 75: 1051-61. PMID 1741497 DOI: 10.1097/00000542-199112000-00018  0.41
1991 Hahin R, Wang GK, Shapiro BI, Strichartz G. Alterations in sodium channel gating produced by the venom of the marine mollusc Conus striatus. Toxicon : Official Journal of the International Society On Toxinology. 29: 245-59. PMID 1646501 DOI: 10.1016/0041-0101(91)90109-5  0.389
1990 Butterworth JF, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology. 72: 711-34. PMID 2157353  0.301
1987 Butterworth JF, Moran JR, Whitesides GM, Strichartz GR. Limited nerve impulse blockade by "leashed" local anesthetics. Journal of Medicinal Chemistry. 30: 1295-302. PMID 2441052 DOI: 10.1021/Jm00391A006  0.334
1987 Strichartz G, Rando T, Wang GK. An integrated view of the molecular toxinology of sodium channel gating in excitable cells. Annual Review of Neuroscience. 10: 237-67. PMID 2436544 DOI: 10.1146/Annurev.Ne.10.030187.001321  0.403
1986 Strichartz G, Rando T, Hall S, Gitschier J, Hall L, Magnani B, Bay CH. On the mechanism by which saxitoxin binds to and blocks sodium channels. Annals of the New York Academy of Sciences. 479: 96-112. PMID 2434011 DOI: 10.1111/J.1749-6632.1986.Tb15564.X  0.378
1986 Strichartz GR, Wang GK. Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves. The Journal of General Physiology. 88: 413-35. PMID 2428923  0.302
1986 Rando TA, Wang GK, Strichartz GR. The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels. Molecular Pharmacology. 29: 467-77. PMID 2422536  0.317
1985 Jackson FR, Gitschier J, Strichartz GR, Hall LM. Genetic modifications of voltage-sensitive sodium channels in Drosophila: gene dosage studies of the seizure locus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 1144-51. PMID 2582101 DOI: 10.1523/Jneurosci.05-05-01144.1985  0.318
1985 Wang GK, Strichartz G. Kinetic analysis of the action of Leiurus scorpion alpha-toxin on ionic currents in myelinated nerve. The Journal of General Physiology. 86: 739-62. PMID 2415671 DOI: 10.1085/Jgp.86.5.739  0.388
1985 Butterworth JF, Moran J, Whitesides G, Strichartz G. BLOCK OF NEURONAL NA+ CHANNELS BY LEASHED LOCAL ANESTHETICS Anesthesiology. 63: A207. DOI: 10.1097/00000542-198509001-00207  0.36
1983 Strichartz G, Bar-Sagi D, Prives J. Differential expression of sodium channel activities during the development of chick skeletal muscle cells in culture. The Journal of General Physiology. 82: 365-84. PMID 6313850 DOI: 10.1085/Jgp.82.3.365  0.367
1982 Wang GK, Strichartz G. Simultaneous modifications of sodium channel gating by two scorpion toxins. Biophysical Journal. 40: 175-9. PMID 6293596 DOI: 10.1016/S0006-3495(82)84473-1  0.416
1981 Hahin R, Strichartz G. Effects of deuterium oxide on the rate and dissociation constants for saxitoxin and tetrodotoxin action. Voltage-clamp studies on frog myelinated nerve. The Journal of General Physiology. 78: 113-39. PMID 6268735 DOI: 10.1085/Jgp.78.2.113  0.391
1981 Cohen I, Attwell D, Strichartz G. The dependence of the maximum rate of rise of the action potential upstroke on membrane properties. Proceedings of the Royal Society of London. Series B, Biological Sciences. 214: 85-98. PMID 6121330 DOI: 10.1098/Rspb.1981.0083  0.319
1980 Strichartz G. Use-dependent conduction block produced by volatile general anesthetic agents. Acta Anaesthesiologica Scandinavica. 24: 402-6. PMID 6970493 DOI: 10.1111/J.1399-6576.1980.Tb01571.X  0.367
1978 Strichartz G, Cohen I. Vmax as a measure of GNa in nerve and cardiac membranes. Biophysical Journal. 23: 153-6. PMID 667304 DOI: 10.1016/S0006-3495(78)85440-X  0.31
1977 Strichartz G. Effects of tertiary local anesthetics and their quaternary derivatives on sodium channels of nerve membranes [proceedings]. Biophysical Journal. 18: 353-4. PMID 890031 DOI: 10.1016/S0006-3495(77)85619-1  0.42
1976 Strichartz G. Molecular mechanisms of nerve block by local anesthetics. Anesthesiology. 45: 421-41. PMID 9844 DOI: 10.1097/00006534-197708000-00125  0.46
1974 Henderson R, Strichartz G. Ion fluxes through the sodium channels of garfish olfactory nerve membranes. The Journal of Physiology. 238: 329-42. PMID 4840874 DOI: 10.1113/Jphysiol.1974.Sp010527  0.545
1974 Henderson R, Ritchie JM, Strichartz GR. Evidence that tetrodotoxin and saxitoxin act at a metal cation binding site in the sodium channels of nerve membrane. Proceedings of the National Academy of Sciences of the United States of America. 71: 3936-40. PMID 4530274 DOI: 10.1073/Pnas.71.10.3936  0.508
1973 Henderson R, Ritchie JM, Strichartz GR. The binding of labelled saxitoxin to the sodium channels in nerve membranes. The Journal of Physiology. 235: 783-804. PMID 4772409 DOI: 10.1113/Jphysiol.1973.Sp010417  0.502
1973 Henderson R, Ritchie JM, Strichartz GR. The binding of labelled saxitoxin to mammalian non-myelinated nerve fibres. The Journal of Physiology. 232: 53P-54P. PMID 4733507  0.444
Low-probability matches (unlikely to be authored by this person)
2011 Huang L, Gao YJ, Wang J, Strichartz G. Shifts in cell-type expression accompany a diminishing role of spinal p38-mapkinase activation over time during prolonged postoperative pain. Anesthesiology. 115: 1281-90. PMID 21975276 DOI: 10.1097/ALN.0b013e31823499cc  0.299
1981 Strichartz GR. Current concepts of the mechanism of action of local anesthetics. Journal of Dental Research. 60: 1460-70. PMID 6265515  0.297
1983 Wang GK, Strichartz GR. Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus. Molecular Pharmacology. 23: 519-33. PMID 6300654  0.297
1981 Strichartz GR. Pharmacological properties of sodium channels in nerve membranes. Advances in Neurology. 31: 343-56. PMID 6275671  0.296
2018 Schreiber KL, Zinboonyahgoon N, Xu X, Spivey T, King T, Dominici L, Partridge A, Golshan M, Strichartz G, Edwards RR. Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes after Breast Surgery. The Journal of Pain : Official Journal of the American Pain Society. PMID 30476655 DOI: 10.1016/J.Jpain.2018.11.004  0.292
2015 Rathmell JP, Strichartz G, Wanderer J. Neosaxitoxin versus Traditional Local Anesthetics: Mechanism of Action and Sites of Notable Effect. Anesthesiology. 123: A23. PMID 26372144 DOI: 10.1097/01.anes.0000470956.02665.a6  0.292
1991 Strichartz G, Drachman D, Latka C, Feldman H. SENSORY AND MOTOR BLOCK OF RAT SCIATIC NERVE IN VIVO PRODUCED BY THE Na+CHANNEL ACTIVATOR VERATRIDINE Anesthesiology. 75: A771-A771. DOI: 10.1097/00000542-199109001-00770  0.288
1984 Moczydlowski E, Hall S, Garber SS, Strichartz GS, Miller C. Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins. The Journal of General Physiology. 84: 687-704. PMID 6096479 DOI: 10.1085/jgp.84.5.687  0.287
2000 Kohane DS, Lu NT, Gökgöl-Kline AC, Shubina M, Kuang Y, Hall S, Strichartz GR, Berde CB. The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Regional Anesthesia and Pain Medicine. 25: 52-9. PMID 10660241 DOI: 10.1016/S1098-7339(00)80011-5  0.284
2015 Schmidt B, Ohri R, Wang JC, Blaskovich P, Kesselring A, Scarborough N, Herman C, Strichartz G. Local pathology and systemic serum bupivacaine after subcutaneous delivery of slow-releasing bupivacaine microspheres. Anesthesia and Analgesia. 120: 36-44. PMID 25360482 DOI: 10.1213/Ane.0000000000000507  0.283
1986 Rando TA, Strichartz GR. Saxitoxin blocks batrachotoxin-modified sodium channels in the node of Ranvier in a voltage-dependent manner. Biophysical Journal. 49: 785-94. PMID 2421797 DOI: 10.1016/S0006-3495(86)83706-7  0.283
2019 Nandi M, Schreiber KL, Martel MO, Cornelius M, Campbell CM, Haythornthwaite JA, Smith MT, Wright J, Aglio LS, Strichartz G, Edwards RR. Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty. Biology of Sex Differences. 10: 23. PMID 31060622 DOI: 10.1186/S13293-019-0237-7  0.282
1993 Wong K, Strichartz GR, Raymond SA. On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve. Anesthesia and Analgesia. 76: 131-43. PMID 8418714  0.281
1995 Popitz-Bergez FA, Leeson S, Strichartz GR, Thalhammer JG. Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. A study in the rat sciatic nerve. Anesthesiology. 83: 583-92. PMID 7661359 DOI: 10.1097/00000542-199509000-00018  0.281
2018 Strichartz G, Khasabov S, Barr T, Wang J, Simone D. Modulation of chronic post-thoracotomy pain by NK-1 neurons in the rostral ventromedial medulla is not paralleled by changes spinal MAPKinase activation The Journal of Pain. 19: S14. DOI: 10.1016/J.Jpain.2017.12.065  0.281
1998 Xiong Z, Strichartz GR. Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells. European Journal of Pharmacology. 363: 81-90. PMID 9877085 DOI: 10.1016/S0014-2999(98)00769-9  0.278
2020 Strichartz G, Gao Y. Dynamics of Spinal Inotropic Glutamate Receptors During the Development of Prolonged Postoperative Pain in the Rat. Medical Research Archives. 8. DOI: 10.18103/mra.v8i2.2042  0.277
2000 Gennery B, Mather LE, Strichartz G. Levobupivacaine: New preclinical and clinical data Seminars in Anesthesia. 19: 132-148. DOI: 10.1053/Sa.2000.6791  0.277
2003 Sinnott CJ, Cogswell III LP, Johnson A, Strichartz GR. On the mechanism by which epinephrine potentiates lidocaine's peripheral nerve block. Anesthesiology. 98: 181-8. PMID 12502995 DOI: 10.1097/00000542-200301000-00028  0.277
2015 Makdessi MJ, Barr TP, Xue W, Strichartz GR. Bupivacaine inhibits endothelin-1-evoked increases in intracellular calcium in model sensory neurons. Acta Anaesthesiologica Scandinavica. 59: 936-45. PMID 25684033 DOI: 10.1111/Aas.12481  0.275
1994 Bainton CR, Strichartz GR. Concentration dependence of lidocaine-induced irreversible conduction loss in frog nerve. Anesthesiology. 81: 657-67. PMID 8092513 DOI: 10.1097/00000542-199409000-00020  0.273
2010 Strichartz G. Beyond neurons: the complex sources of pain transduction. Pain. 148: 180-1. PMID 19917519 DOI: 10.1016/j.pain.2009.10.017  0.272
1994 Lambert LA, Lambert DH, Strichartz GR. Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology. 80: 1082-93. PMID 8017646  0.271
1984 Jackson FR, Wilson SD, Strichartz GR, Hall LM. Two types of mutants affecting voltage-sensitive sodium channels in Drosophila melanogaster. Nature. 308: 189-91. PMID 6322008  0.271
2008 Strichartz GR. Novel ideas of local anaesthetic actions on various ion channels to ameliorate postoperative pain. British Journal of Anaesthesia. 101: 45-7. PMID 18487246 DOI: 10.1093/bja/aen101  0.271
1986 Moczydlowski E, Olivera BM, Gray WR, Strichartz GR. Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins. Proceedings of the National Academy of Sciences of the United States of America. 83: 5321-5. PMID 2425365  0.27
1994 Shin HC, Park HJ, Raymond SA, Strichartz GR. Potentiation by capsaicin of lidocaine's tonic impulse block in isolated rat sciatic nerve. Neuroscience Letters. 174: 14-6. PMID 7970146 DOI: 10.1016/0304-3940(94)90107-4  0.27
1991 DeBin JA, Strichartz GR. Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus. Toxicon : Official Journal of the International Society On Toxinology. 29: 1403-8. PMID 1726031 DOI: 10.1016/0041-0101(91)90128-E  0.27
1987 Wang GK, Brodwick MS, Eaton DC, Strichartz GR. Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation. The Journal of General Physiology. 89: 645-67. PMID 2438374  0.269
1984 Strichartz GR, Small RK, Pfenninger KH. Components of the plasma membrane of growing axons. III. Saxitoxin binding to sodium channels. The Journal of Cell Biology. 98: 1444-52. PMID 6325471 DOI: 10.1083/Jcb.98.4.1444  0.269
1997 Popitz-Bergez FA, Leeson S, Thalhammer JG, Strichartz GR. Intraneural lidocaine uptake compared with analgesic differences between pregnant and nonpregnant rats. Regional Anesthesia. 22: 363-71. PMID 9223204  0.266
2016 Nandi M, Cornelius M, Campbell C, Smith M, Haythornthwaite J, Wright J, Edwards R, Strichartz G. (103) Sex differences in pain and functioning among Total Knee Arthroplasty patients. The Journal of Pain : Official Journal of the American Pain Society. 17: S1-S2. PMID 28162297 DOI: 10.1016/J.Jpain.2016.01.006  0.266
1988 Castle NA, Strichartz GR. Palytoxin induces a relatively non-selective cation permeability in frog sciatic nerve which can be inhibited by cardiac glycosides. Toxicon : Official Journal of the International Society On Toxinology. 26: 941-51. PMID 2904712 DOI: 10.1016/0041-0101(88)90259-0  0.265
1981 Strichartz GR, Hanson Bay CM. Saxitoxin binding in nerves from walking legs of the lobster Homarus americanus. Two classes of receptors. The Journal of General Physiology. 77: 205-21. PMID 6267162  0.264
2012 Wang GK, Strichartz GR. State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution. Biochemistry (Moscow) Supplement. Series a, Membrane and Cell Biology. 6: 120-127. PMID 23710324 DOI: 10.1134/S1990747812010151  0.264
1984 Strichartz G. Structural determinants of the affinity of saxitoxin for neuronal sodium channels. Electrophysiological studies on frog peripheral nerve. The Journal of General Physiology. 84: 281-305. PMID 6092517  0.262
1997 Choi RH, Birknes JK, Popitz-Bergez FA, Kissin I, Strichartz GR. Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats. Life Sciences. 61: PL 177-84. PMID 9315513 DOI: 10.1016/S0024-3205(97)00664-4  0.259
2002 Wang GK, Strichartz GR. Therapeutic Na+ channel blockers beneficial for pain syndromes Drug Development Research. 54: 154-158. DOI: 10.1002/ddr.10014  0.258
1977 Cohen IS, Strichartz GR. On the voltage-dependent action of tetrodotoxin. Biophysical Journal. 17: 275-9. PMID 843585 DOI: 10.1016/S0006-3495(77)85656-7  0.258
1989 Chernoff DM, Strichartz GR. Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue. The Journal of General Physiology. 93: 1075-90. PMID 2549174  0.256
2003 Sinnott CJ, Strichartz GR. Levobupivacaine versus ropivacaine for sciatic nerve block in the rat. Regional Anesthesia and Pain Medicine. 28: 294-303. PMID 12945022 DOI: 10.1016/S1098-7339(03)00188-3  0.253
2003 Nakamura T, Popitz-Bergez F, Birknes J, Strichartz GR. The critical role of concentration for lidocaine block of peripheral nerve in vivo: studies of function and drug uptake in the rat. Anesthesiology. 99: 1189-97. PMID 14576558 DOI: 10.1097/00000542-200311000-00028  0.252
1991 Guo XT, Castle NA, Chernoff DM, Strichartz GR. Comparative inhibition of voltage-gated cation channels by local anesthetics. Annals of the New York Academy of Sciences. 625: 181-99. PMID 1647723  0.251
1989 Son SL, Concus A, Crill E, Chernoff D, Wang GK, Strichartz G. Stereoselective effects of local anesthetics reveal two sites of action on neuronal sodium channels Regional Anesthesia. 14: 78-78.  0.249
2015 Soens M, Wang JC, Berta T, Strichartz G. Systemic Progesterone Administration in Early Life Alters the Hyperalgesic Responses to Surgery in the Adult: A Study on Female Rats. Anesthesia and Analgesia. 121: 545-55. PMID 26076389 DOI: 10.1213/ANE.0000000000000800  0.248
2018 Hamaya C, Barr T, Strichartz GR. Multiple Inhibitory Mechanisms of Lidocaine on Bradykinin Receptor Activity in Model Sensory Neurons. Regional Anesthesia and Pain Medicine. PMID 29557886 DOI: 10.1097/Aap.0000000000000758  0.246
1991 Gold MR, Strichartz GR. Use-dependent block of atrial sodium current by ethylisopropylamiloride. Journal of Cardiovascular Pharmacology. 17: 792-9. PMID 1713995  0.245
2000 Fareed MU, Hans GH, Atanda A, Strichartz GR, Davar G. Pharmacological characterization of acute pain behavior produced by application of endothelin-1 to rat sciatic nerve The Journal of Pain. 1: 46-53. DOI: 10.1016/S1526-5900(00)90087-7  0.244
2000 Fareed MU, Hans GH, Atanda A, Strichartz GR, Davar G. Pharmacological characterization of acute pain behavior produced by application of endothelin-1 to rat sciatic nerve Journal of Pain. 1: 46-53.  0.244
1994 DeBin JA, Wood MR, Pfenninger KH, Strichartz GR. A chloride channel reconstituted from fetal rat brain growth cones. The Journal of Membrane Biology. 141: 7-19. PMID 7966248 DOI: 10.1007/Bf00232869  0.244
2008 Kamath R, Strichartz G, Rosenthal D. Cartilage toxicity from local anesthetics. Skeletal Radiology. 37: 871-3. PMID 18685843 DOI: 10.1007/s00256-008-0567-8  0.241
2006 Weinberg GL, Ripper R, Murphy P, Edelman LB, Hoffman W, Strichartz G, Feinstein DL. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Regional Anesthesia and Pain Medicine. 31: 296-303. PMID 16857549 DOI: 10.1016/J.Rapm.2005.02.011  0.236
1980 Strichartz GR, Oxford GS, Ramon F. Effects of the dipolar form of phloretin on potassium conductance in squid giant axons. Biophysical Journal. 31: 229-46. PMID 6266534 DOI: 10.1016/S0006-3495(80)85053-3  0.236
1994 Strichartz GR, Manning T, Datta S. Irreversible conduction block in mammalian nerves by direct application of 2% and 5% lidocaine Regional Anesthesia. 19: 21-21.  0.233
2010 Khodorova A, Strichartz GR. Remarkably long-lasting tachyphylaxis of pain responses to ET-1: evidence against central nervous system involvement. Canadian Journal of Physiology and Pharmacology. 88: 668-75. PMID 20628433 DOI: 10.1139/Y10-044  0.233
1993 DeBin JA, Maggio JE, Strichartz GR. Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. The American Journal of Physiology. 264: C361-9. PMID 8383429 DOI: 10.1152/Ajpcell.1993.264.2.C361  0.233
1987 Thalhammer JG, Raymond SA, Strichartz GR. Effects of lidocaine on activity of single cutaneous afferents in rat sciatic nerve Pain. 30: S383. DOI: 10.1016/0304-3959(87)91822-7  0.233
1973 Strichartz GR. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. The Journal of General Physiology. 62: 37-57. PMID 4541340  0.229
1988 Benzon HT, Strichartz GR, Gissen AJ, Shanks CA, Covino BG, Datta S. Developmental neurophysiology of mammalian peripheral nerves and age-related differential sensitivity to local anaesthetic. British Journal of Anaesthesia. 61: 754-60. PMID 3207547 DOI: 10.1093/bja/61.6.754  0.228
1987 Benzon HT, Gissen AJ, Strichartz GR, Avram MJ, Covino BG. The effect of polyethylene glycol on mammalian nerve impulses. Anesthesia and Analgesia. 66: 553-9. PMID 3578866  0.226
2015 Wang CF, Russell G, Wang SY, Strichartz GR, Wang GK. R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. Anesthesia and Analgesia. PMID 26646348 DOI: 10.1213/ANE.0000000000001086  0.226
2000 Strichartz G. Pathways and obstacles to local anesthesia, a personal account: the 2000 Gaston Labat lecture. Regional Anesthesia and Pain Medicine. 25: 447-51. PMID 11009228 DOI: 10.1053/rapm.2000.8575  0.226
1989 Raymond SA, Steffensen SC, Gugino LD, Strichartz GR. The role of length of nerve exposed to local anesthetics in impulse blocking action. Anesthesia and Analgesia. 68: 563-70. PMID 2785778  0.225
1979 Strichartz GR, Rogart RB, Ritchie JM. Binding of radioactively labeled saxitoxin to the squid giant axon. The Journal of Membrane Biology. 48: 357-64. PMID 490630 DOI: 10.1007/BF01869446  0.223
1995 Vladimirova M, Thalhammer JG, Drmedvet DVM, Strichartz GR. Effects of veratridine on sciatic nerve-mediated functions in rat Regional Anesthesia. 20: 129.  0.222
1995 Lee Son S, Thalhaimner JG, Strichartz GR. Uptake and washout of lidocaine in rat sciatic nerve: An in vitro study Regional Anesthesia. 20: 47.  0.221
1979 Tang CM, Strichartz GR, Orkand RK. Sodium channels in axons and glial cells of the optic nerve of Necturus maculosa. The Journal of General Physiology. 74: 629-42. PMID 512633  0.22
2015 Strichartz G, Wang J, Khasabov S, Kojima K, Simone D, Vacanti C. (285) Spinal cord-derived neural stem cells restore hyperalgesic responses previously diminished by chemical ablation of NK-1 expressing neurons in the rat spinal cord The Journal of Pain. 16: S47. DOI: 10.1016/J.Jpain.2015.01.203  0.22
2010 Khodorova A, Strichartz GR. Contralateral paw sensitization following injection of endothelin-1: effects of local anesthetics differentiate peripheral and central processes. Neuroscience. 165: 553-60. PMID 19874873 DOI: 10.1016/j.neuroscience.2009.10.049  0.219
1975 Hille B, Ritchie JM, Strichartz GR. The effect of surface charge on the nerve membrane on the action of tetrodotoxin and saxitoxin in frog myelinated nerve. The Journal of Physiology. 250: 34P-35P. PMID 1177130  0.219
2017 Wang JC, Strichartz GR. Prevention of Chronic Post-Thoracotomy Pain in Rats by Intrathecal Resolvin D1 and D2: Effectiveness of perioperative and delayed drug delivery. The Journal of Pain : Official Journal of the American Pain Society. PMID 28063958 DOI: 10.1016/j.jpain.2016.12.012  0.218
1990 Strichartz GR, Sanchez V, Arthur GR, Chafetz R, Martin D. Fundamental properties of local anesthetics. II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs. Anesthesia and Analgesia. 71: 158-70. PMID 2375517  0.217
1987 Tamplin ML, Colwell RR, Hall S, Kogure K, Strichartz GR. Sodium-channel inhibitors produced by enteropathogenic Vibrio cholerae and Aeromonas hydrophila. Lancet. 1: 975. PMID 2436014 DOI: 10.1016/S0140-6736(87)90317-5  0.216
1992 Raymond SA, Abrams SB, Raemer DB, Philip JH, Strichartz GR. The NerveSeeker: a system for automated nerve localization. Regional Anesthesia. 17: 151-62. PMID 1606098  0.216
1995 Li YM, Wingrove DE, Too HP, Marnerakis M, Stimson ER, Strichartz GR, Maggio JE. Local anesthetics inhibit substance P binding and evoked increases in intracellular Ca2+. Anesthesiology. 82: 166-73. PMID 7530414 DOI: 10.1097/00000542-199501000-00021  0.216
1995 Popitz-Beraez FA, Strichartz GR, Thalhammer JG. Differences in lidocaine uptake in the sciatic nerve of the pregnant rat in vivo Regional Anesthesia. 20: 88.  0.215
1987 Raymond SA, Gugino LD, Thalhammer JG, Strichartz GR. Critical length: Partial impulse block increase with length of nerve exposed to lidocaine Pain. 30: S384. DOI: 10.1016/0304-3959(87)91823-9  0.215
2017 Khasabov SG, Wang JC, Simone DA, Strichartz GR. A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain. Pain. 158: 1332-1341. PMID 28622274 DOI: 10.1097/J.Pain.0000000000000919  0.215
1982 Strichartz G. Structure of the saxitoxin binding site at sodium channels in nerve membranes. Exchange of tritium from bound toxin molecules. Molecular Pharmacology. 21: 343-50. PMID 6285170  0.215
1979 Krueger BK, Ratzlaff RW, Strichartz GR, Blaustein MP. Saxitoxin binding to synaptosomes, membranes, and solubilized binding sites from rat brain. The Journal of Membrane Biology. 50: 287-310. PMID 513116 DOI: 10.1007/BF01868894  0.213
1994 Popitz-Bergez FA, Lee-Son S, Thalhairaner JG, Strichartz GR. Intraneural lidocaine uptake and distribution during sciatic nerve block neurologically assessed in the rat Regional Anesthesia. 19: 20-20.  0.212
2009 Ji RR, Gereau RW, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Research Reviews. 60: 135-48. PMID 19150373 DOI: 10.1016/J.Brainresrev.2008.12.011  0.212
2000 Sinnott CJ, Garfield JM, Thalhammer JG, Strichartz GR. Addition of sodium bicarbonate to lidocaine decreases the duration of peripheral nerve block in the rat. Anesthesiology. 93: 1045-52. PMID 11020760  0.212
1987 Benzon HT, Gissen AJ, Strichartz GR, Avram MJ, Covino BG. The Effect of Polyethylene Glycol on Mammalian Nerve Impulses Anesthesia & Analgesia. 66: 553???559. DOI: 10.1213/00000539-198706000-00012  0.21
2003 Khodorova A, Navarro B, Jouaville LS, Murphy JE, Rice FL, Mazurkiewicz JE, Long-Woodward D, Stoffel M, Strichartz GR, Yukhananov R, Davar G. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nature Medicine. 9: 1055-61. PMID 12847519 DOI: 10.1038/Nm885  0.21
1976 Ritchie JM, Rogart RB, Strichartz GR. A new method for labelling saxitoxin and its binding to non-myelinated fibres of the rabbit vagus, lobster walking leg, and garfish olfactory nerves. The Journal of Physiology. 261: 477-94. PMID 978583  0.21
2017 Khasabov SG, Chi-Fei Wang J, Simone DA, Strichartz GR. A role for nk-1 neurons in the rostral ventromedial medulla in the development of chronic post-thoracotomy pain. Pain. PMID 28394854 DOI: 10.1097/j.pain.0000000000000919  0.209
1995 Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR. Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology. 82: 1013-25. PMID 7717536  0.208
2007 Mujenda FH, Duarte AM, Reilly EK, Strichartz GR. Cutaneous endothelin-A receptors elevate post-incisional pain. Pain. 133: 161-73. PMID 17467172 DOI: 10.1016/j.pain.2007.03.021  0.208
1986 Bokesch PM, Post C, Strichartz G. Structure-activity relationship of lidocaine homologs producing tonic and frequency-dependent impulse blockade in nerve. The Journal of Pharmacology and Experimental Therapeutics. 237: 773-81. PMID 2423682  0.207
2005 Duarte AM, Pospisilova E, Reilly E, Mujenda F, Hamaya Y, Strichartz GR. Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat. Anesthesiology. 103: 113-25. PMID 15983463 DOI: 10.1097/00000542-200507000-00018  0.206
1990 Raymond SA, Strichartz GR. Further comments on the failure of impulse propagation in nerves marginally blocked by local anesthetic. Anesthesia and Analgesia. 70: 121-2. PMID 2297095 DOI: 10.1213/00000539-199001000-00030  0.205
2013 Ohri R, Wang JC, Blaskovich PD, Pham LN, Costa DS, Nichols GA, Hildebrand WP, Scarborough NL, Herman CJ, Strichartz GR. Inhibition by local bupivacaine-releasing microspheres of acute postoperative pain from hairy skin incision. Anesthesia and Analgesia. 117: 717-30. PMID 23921651 DOI: 10.1213/Ane.0B013E3182A00851  0.204
2003 Araujo MC, Sinnott CJ, Strichartz GR. Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. Pain. 103: 21-9. PMID 12749955 DOI: 10.1016/S0304-3959(02)00350-0  0.203
2009 Shrestha S, Gracias NG, Mujenda F, Khodorova A, Vasko MR, Strichartz GR. Local antinociception induced by endothelin-1 in the hairy skin of the rat's back. The Journal of Pain : Official Journal of the American Pain Society. 10: 702-14. PMID 19559389 DOI: 10.1016/j.jpain.2008.12.005  0.203
1999 Sinnott CJ, Garfield JM, Strichartz GR. Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat. Pain. 80: 521-31. PMID 10342413 DOI: 10.1016/S0304-3959(98)00245-0  0.202
1991 Gold MR, Strichartz GR. Acute effects of repetitive depolarization on sodium current in chick myocytes. The American Journal of Physiology. 260: H1810-8. PMID 1647695  0.2
2011 Barr TP, Kam S, Khodorova A, Montmayeur JP, Strichartz GR. New perspectives on the endothelin axis in pain. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 532-40. PMID 21352917 DOI: 10.1016/J.Phrs.2011.02.002  0.199
1998 Nakamura T, Popitz-Bergez F, Strichartz GR. VOLUME vs CONCENTRATION DETERMINANTS OF DOSE-DEPENDENT NERVE BLOCKADE BY LIDOCAINE IN RATS Anesthesiology. 89: 858A. DOI: 10.1097/00000542-199809150-00033  0.199
2001 Sinnott CJ, Garfield JM, Thalhammer JG, Strichartz: GR. Addition of sodium bicarbonate to lidocaine decreases the duration of peripheral nerve block in rat. (Harvard Medical School, Boston, MA) Anesthesiology 2000;93:1045-1052. Pain Practice. 1: 202-202. DOI: 10.1046/j.1533-2500.2001.001002202.x  0.199
2014 Barr TP, Hrnjic A, Khodorova A, Sprague JM, Strichartz GR. Sensitization of cutaneous neuronal purinergic receptors contributes to endothelin-1-induced mechanical hypersensitivity. Pain. 155: 1091-101. PMID 24569146 DOI: 10.1016/J.Pain.2014.02.014  0.198
1987 Chesnut TJ, Carpenter DO, Strichartz GR. Effects of venom from Conus striatus on the delayed rectifier potassium current of molluscan neurons. Toxicon : Official Journal of the International Society On Toxinology. 25: 267-78. PMID 3590211 DOI: 10.1016/0041-0101(87)90255-8  0.197
1999 Xiong Z, Bukusoglu C, Strichartz GR. Local anesthetics inhibit the G protein-mediated modulation of K+ and Ca++ currents in anterior pituitary cells. Molecular Pharmacology. 55: 150-8. PMID 9882709  0.197
1993 Thalhammer JG, Drmedvet DVM, Vladimirova M, Strichartz GR. Differential evaluation of sensory and motor function during peripheral nerve block with lidocaine in rats Regional Anesthesia. 18: 110.  0.196
2013 Chi-Fei Wang J, Hung CH, Gerner P, Ji RR, Strichartz GR. The Qualitative Hyperalgesia Profile: A New Metric to Assess Chronic Post-Thoracotomy Pain. The Open Pain Journal. 6: 190-198. PMID 24567767 DOI: 10.2174/1876386301306010190  0.195
2000 Khodorova AB, Strichartz GR. The addition of dilute epinephrine produces equieffectiveness of bupivacaine enantiomers for cutaneous analgesia in the rat. Anesthesia and Analgesia. 91: 410-6. PMID 10910859  0.195
1980 Bay CM, Strichartz GR. Saxitoxin binding to sodium channels of rat skeletal muscles. The Journal of Physiology. 300: 89-103. PMID 6247488  0.194
2006 Zhuang ZY, Wen YR, Zhang DR, Borsello T, Bonny C, Strichartz GR, Decosterd I, Ji RR. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3551-60. PMID 16571763 DOI: 10.1523/JNEUROSCI.5290-05.2006  0.193
2015 Hung CH, Wang JC, Strichartz G. Spontaneous Chronic Pain After Experimental Thoractomy Revealed by Conditioned Place Preference: morphine differentiates tactile evoked pain from spontaneous pain. The Journal of Pain : Official Journal of the American Pain Society. PMID 26116369 DOI: 10.1016/j.jpain.2015.06.006  0.193
2000 Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M. Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. Journal of Neuroscience Research. 60: 666-77. PMID 10820438 DOI: 10.1002/(Sici)1097-4547(20000601)60:5<666::Aid-Jnr12>3.0.Co;2-0  0.192
1984 Strichartz G. Membrane Potential-Dependent Ion Channels in Cell Membrane: Phylogenetic and Developmental Approaches.S. Hagiwara The Quarterly Review of Biology. 59: 464-464. DOI: 10.1086/414075  0.19
2003 Taheri S, Cogswell LP, Gent A, Strichartz GR. Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein. The Journal of Pharmacology and Experimental Therapeutics. 304: 71-80. PMID 12490577 DOI: 10.1124/jpet.102.042028  0.189
1983 Dodt HU, Strichartz GR, Zimmermann M. Phenol solutions differentially block conduction in cutaneous nerve fibers of the cat. Neuroscience Letters. 42: 323-7. PMID 6664635 DOI: 10.1016/0304-3940(83)90282-3  0.188
2015 Wang CF, Russell G, Strichartz GR, Wang GK. The Local and Systemic Actions of Duloxetine in Allodynia and Hyperalgesia Using a Rat Skin Incision Pain Model. Anesthesia and Analgesia. 121: 532-44. PMID 26049779 DOI: 10.1213/ANE.0000000000000794  0.188
2001 Gokin AP, Fareed MU, Pan HL, Hans G, Strichartz GR, Davar G. Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5358-66. PMID 11438612  0.188
1997 Popitz-Bergez FA, Choi RH, Birknes JK, Kissin I, Strichartz GR. A765 TACHYPHYLAXIS TO LIDOCAINE DURING PERIPHERAL NERVE BLOCKS AND INFILTRATION ANESTHESIA Anesthesiology. 87: 765A. DOI: 10.1097/00000542-199709001-00765  0.187
1985 Post C, Butterworth JF, Strichartz GR, Karlsson JA, Persson CG. Tachykinin antagonists have potent local anaesthetic actions. European Journal of Pharmacology. 117: 347-54. PMID 2416579 DOI: 10.1016/0014-2999(85)90008-1  0.187
2014 Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish J. Research at the Harvard Anesthesia Departments. Anesthesiology. 121: 1141-3. PMID 25299744 DOI: 10.1097/Aln.0000000000000483  0.186
1994 Wang ZY, Tung SR, Strichartz GR, HÃ¥kanson R. Investigation of the specificity of FK 888 as a tachykinin NK1 receptor antagonist. British Journal of Pharmacology. 111: 1342-6. PMID 7518299  0.185
2002 Khodorova A, Fareed MU, Gokin A, Strichartz GR, Davar G. Local injection of a selective endothelin-B receptor agonist inhibits endothelin-1-induced pain-like behavior and excitation of nociceptors in a naloxone-sensitive manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7788-96. PMID 12196602  0.185
1980 Gitschier J, Strichartz GR, Hall LM. Saxitoxin binding to sodium channels in head extracts from wild-type and tetrodotoxin-sensitive strains of Drosophila melanogaster. Biochimica Et Biophysica Acta. 595: 291-303. PMID 6766315  0.179
1980 Gitschier J, Strichartz GR, Hall LM. Saxitoxin binding to sodium channels in head extracts from wild-type and tetrodotoxin-sensitive strains of Drosophila melanogaster Bba - Biomembranes. 595: 291-303. DOI: 10.1016/0005-2736(80)90091-7  0.179
1993 Strichartz GR. Specific enhancement by fentanyl of the effects of intrathecal bupivacaine on nociceptive afferent but not on sympathetic efferent pathways in dogs Anesthesiology. 79: 25A.  0.179
1987 Bokesch PM, Raymond SA, Strichartz GR. Dependence of lidocaine potency on pH and PCO2. Anesthesia and Analgesia. 66: 9-17. PMID 3099602  0.179
1993 Butterworth JF, Strichartz GR. The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers. Anesthesia and Analgesia. 76: 295-301. PMID 8093828  0.177
1995 Strichartz GR, Hall S, Magnani B, Hong CY, Kishi Y, Debin JA. The potencies of synthetic analogues of saxitoxin and the absolute stereoselectivity of decarbamoyl saxitoxin. Toxicon : Official Journal of the International Society On Toxinology. 33: 723-37. PMID 7676464 DOI: 10.1016/0041-0101(95)00031-G  0.175
2002 Hamaya Y, Abdelrazek H, Strichartz GR. Comparative Potency for Impulse-Blockade and for Cutaneous Analgesia of Traditional and Novel Local Anesthetics Anesthesiology. 96: A854. DOI: 10.1097/00000542-200209002-00854  0.174
1976 Ritchie JM, Rogart RB, Strichartz G. Proceedings: Binding to nerve and muscle of saxitoxin labelled by a new method of tritium exchange. The Journal of Physiology. 258: 99P-100P. PMID 957203  0.173
2015 Strichartz GR, Wang JC, Blaskovich P, Ohri R. Mitigation of experimental, chronic post-thoracotomy pain by preoperative infiltration of local slow-release bupivacaine microspheres. Anesthesia and Analgesia. 120: 1375-84. PMID 25902323 DOI: 10.1213/Ane.0000000000000768  0.172
2006 Balonov K, Khodorova A, Strichartz GR. Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors. Experimental Biology and Medicine (Maywood, N.J.). 231: 1165-70. PMID 16741070  0.172
2000 Sinnott CJ, Garfield JM, Zeitlin A, Teo S, Wu M, Chen J, Shafer SL, Strichartz GR. Enantioselective relief of neuropathic pain by systemic mexiletine in the rat Journal of Pain. 1: 128-137.  0.171
1992 Butterworth JF, Strichartz GR. Differential Nerve Block by the a2 Adrenergic Receptor Agonists Clonidine and Guanfacine Anesthesiology. 77: A861. DOI: 10.1097/00000542-199209001-00861  0.168
1994 Wang ZY, Tung SR, Strichartz GR, HÃ¥kanson R. Non-specific actions of the non-peptide tachykinin receptor antagonists, CP-96,345, RP 67580 and SR 48968, on neurotransmission. British Journal of Pharmacology. 111: 179-84. PMID 8012694  0.165
2011 Montmayeur JP, Barr TP, Kam SA, Packer SJ, Strichartz GR. ET-1 induced Elevation of intracellular calcium in clonal neuronal and embryonic kidney cells involves endogenous endothelin-A receptors linked to phospholipase C through Gα(q/11). Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 64: 258-67. PMID 21515378 DOI: 10.1016/J.Phrs.2011.04.003  0.165
2006 Yanagidate F, Strichartz GR. Bupivacaine inhibits activation of neuronal spinal extracellular receptor-activated kinase through selective effects on ionotropic receptors. Anesthesiology. 104: 805-14. PMID 16571978 DOI: 10.1097/00000542-200604000-00027  0.164
2007 McNally MA, Baek RC, Avila RL, Seyfried TN, Strichartz GR, Kirschner DA. Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis. Journal of Negative Results in Biomedicine. 6: 8. PMID 17623103 DOI: 10.1186/1477-5751-6-8  0.164
2015 Strichartz GR, Khodorova A, Wang JC, Chen YW, Huang CC. Contralateral Hyperalgesia from Injection of Endothelin-1 into the Ipsilateral Paw Requires Efferent Conduction into the Contralateral Paw. Anesthesia and Analgesia. PMID 26218866 DOI: 10.1213/ANE.0000000000000858  0.163
2007 Strichartz G. 42 Workshop Summary: MAPK ACTIVATION IN NEUROPATHIC PAIN European Journal of Pain. 11: S17-S17. DOI: 10.1016/j.ejpain.2007.03.056  0.161
2014 Ohri R, Wang JC, Pham L, Blaskovich PD, Costa D, Nichols G, Hildebrand W, Scarborough N, Herman C, Strichartz GR. Prolonged amelioration of experimental postoperative pain by bupivacaine released from microsphere-coated hernia mesh. Regional Anesthesia and Pain Medicine. 39: 97-107. PMID 24513957 DOI: 10.1097/Aap.0000000000000062  0.161
1997 Huang JH, Thalhammer JG, Raymond SA, Strichartz GR. Susceptibility to lidocaine of impulses in different somatosensory afferent fibers of rat sciatic nerve. The Journal of Pharmacology and Experimental Therapeutics. 282: 802-11. PMID 9262344  0.157
1983 Strichartz GR. Physiology and Electrochemistry of Nerve Fibers. Ichiji Tasaki The Quarterly Review of Biology. 58: 288-289. DOI: 10.1086/413333  0.151
1996 Waikar SS, Thalhammer JG, Raymond SA, Huang JH, Chang DS, Strichartz GR. Mechanoreceptive afferents exhibit functionally-specific activity dependent changes in conduction velocity. Brain Research. 721: 91-100. PMID 8793088 DOI: 10.1016/0006-8993(96)00165-5  0.15
2018 Ende HB, Soens MA, Nandi M, Strichartz GR, Schreiber KL. Association of Interindividual Variation in Plasma Oxytocin With Postcesarean Incisional Pain. Anesthesia and Analgesia. PMID 29916862 DOI: 10.1213/Ane.0000000000003567  0.15
1994 Desai S, Hadlock T, Messam C, Chafetz R, Strichartz G. Ionization and adsorption of a series of local anesthetics in detergent micelles: studies of drug fluorescence. The Journal of Pharmacology and Experimental Therapeutics. 271: 220-8. PMID 7965718  0.15
1990 Chernoff DM, Strichartz GR. Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophysical Journal. 58: 69-81. PMID 2166602 DOI: 10.1016/S0006-3495(90)82354-7  0.148
1981 Strichartz GR. Relative potencies of several derivatives of saxitoxin: Electrophysiological and toxin binding studies Biophysical Journal. 33: T-PM-D7.  0.148
1988 Raymond SA, Steffensen SC, Gugino LD, Strichartz GR. Critical exposure length for nerve block of myelinated fibers with lidocaine exceeds 3 nodes Regional Anesthesia. 13: 46.  0.147
1993 Chernoff DM, Strichartz GR, Piwnica-Worms D. Membrane potential determination in large unilamellar vesicles with hexakis(2-methoxyisobutylisonitrile)technetium(I). Biochimica Et Biophysica Acta. 1147: 262-6. PMID 8476920 DOI: 10.1016/0005-2736(93)90011-N  0.147
2004 Lambert DH, Lambert LA, Strichartz GR. Questioning the mechanism of nerve injury. Anesthesiology. 101: 1249; author reply 1. PMID 15505479  0.147
1988 Strichartz GR. Through the eye of the channel: considerations of a reductionist view of general anesthesia. Anesthesiology. 69: 155-6. PMID 2457339  0.145
2002 Takenaka-Hamaya C, Strichartz GR. Local Anesthetic Actions on Changes of Intracellular Calcium Induced by Bradykinin in Model Sensory Neurons Anesthesiology. 96: A976. DOI: 10.1097/00000542-200209002-00976  0.144
1994 Wang ZY, Feng DM, Wang YL, Tung SR, Wong K, Strichartz GR, Folkers K, HÃ¥kanson R. Pharmacological assessment of spantide II analogues. European Journal of Pharmacology. 260: 121-8. PMID 7527343 DOI: 10.1016/0014-2999(94)90327-1  0.143
1999 Moller RA, Datta S, Strichartz GR. Beta-estradiol acutely potentiates the depression of cardiac excitability by lidocaine and bupivacaine. Journal of Cardiovascular Pharmacology. 34: 718-27. PMID 10547089 DOI: 10.1097/00005344-199911000-00014  0.142
2001 Gokin AP, Philip B, Strichartz GR. Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve. Anesthesiology. 95: 1441-54. PMID 11748404 DOI: 10.1097/00000542-200112000-00025  0.141
1987 Sanchez V, Arthur GR, Strichartz GR. Fundamental properties of local anesthetics. I. The dependence of lidocaine's ionization and octanol:buffer partitioning on solvent and temperature. Anesthesia and Analgesia. 66: 159-65. PMID 3813059  0.137
2013 Barr TP, Albrecht PJ, Hou Q, Mongin AA, Strichartz GR, Rice FL. Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. Plos One. 8: e56744. PMID 23457608 DOI: 10.1371/Journal.Pone.0056744  0.136
1988 Butterworth JF, Lief PA, Strichartz GR. The pH-dependent local anesthetic activity of diethylaminoethanol, a procaine metabolite. Anesthesiology. 68: 501-6. PMID 3258481  0.134
1981 Hahin R, Wang GK, Strichartz GR. Modification of sodium conductance kinetics by venom of the marine mollusc Conus striatus Biophysical Journal. 33: M-PM-Po90.  0.132
1993 Raymond SA, Thalhammer JG, Drmedvet DVM, Popitz-Bergez FA, Rappoport M, Strichartz GR. Impulse activity produces fxjnctionally specific changes in conduction latency that relate to conduction safety in rat sciatic fibers Regional Anesthesia. 18: 108.  0.13
1990 Raymond SA, Thalhammer JG, Popitz-Bergez F, Strichartz GR. Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat. Brain Research. 526: 318-21. PMID 2257488 DOI: 10.1016/0006-8993(90)91239-D  0.13
1989 Raymond S, Wong K, Strichartz G. MECHANISMS FOR POTENTIATION OF LOCAL ANESTHETIC ACTION BY CO2 Anesthesiology. 71: A711. DOI: 10.1097/00000542-198909001-00711  0.126
1994 Thalhammer JG, Raymond SA, Popitz-Bergez FA, Strichartz GR. Modality-dependent modulation of conduction by impulse activity in functionally characterized single cutaneous afferents in the rat. Somatosensory & Motor Research. 11: 243-57. PMID 7887056 DOI: 10.3109/08990229409051392  0.123
1988 Sanchez V, Ferrante FM, Cibotti N, Strichartz GR. Partitioning of tetracaine base and cation into phospholipid membranes: Relevance to anesthetic potency Regional Anesthesia. 13: 81.  0.123
2001 Cogswell LP, Raines DE, Parekh S, Jonas O, Maggio JE, Strichartz GR. Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein. Journal of Pharmaceutical Sciences. 90: 1407-23. PMID 11745793 DOI: 10.1002/Jps.1093  0.117
2007 Zhang J, Hadlock T, Gent A, Strichartz GR. Tetracaine-membrane interactions: effects of lipid composition and phase on drug partitioning, location, and ionization. Biophysical Journal. 92: 3988-4001. PMID 17351014 DOI: 10.1529/biophysj.106.102434  0.115
1994 Strichartz GR. Activation of brain acetylcholine receptors by neuromuscular blocking drugs: A possible mechanism of neurotoxicity Anesthesiology. 80: 29A.  0.114
1994 Strichartz G. Volatile anesthetic-induced efflux of calcium from IP3-gated stores in clonal (GH3) pituitary cells Anesthesiology. 80: 27A-28A.  0.108
1998 Holst D, Meissner K, Möllmann M, Strichartz GR. Neurotoxicity of local anesthetics for continuous spinal anaesthesia Regional Anesthesia and Pain Medicine. 23: 82.  0.102
1984 Strichartz GR, Bokesch PM. Mode of Action of Local Anesthetics Asa Refresher Courses in Anesthesiology. 12: 199-210. DOI: 10.1097/00126869-198412000-00015  0.094
1998 Alvaro E, Strichartz G. OR 1 Elevation of intracellular calcium in prototypical sensory neurons by lidocaine Journal of Endodontics. 24: 271-300. DOI: 10.1016/S0099-2399(98)80112-X  0.093
1984 Wildsmith JA, Strichartz GR. Local anaesthetic drugs--an historical perspective. British Journal of Anaesthesia. 56: 937-9. PMID 6380551  0.088
2008 Gerner P, Strichartz GR. Sensory and motor complications of local anesthetics. Muscle & Nerve. 37: 421-5. PMID 18236466 DOI: 10.1002/mus.20967  0.088
1992 Lambert LA, Lambert DH, Strichartz GR. Potential neurotoxicity of lidocaine and dextrose solutions used for spinal anesthesia Regional Anesthesia. 17: 164.  0.088
1992 Lambert DH, Lambert LA, Strichartz GR. POTENTIAL NEUROTOXICITY OF LIDOCAINE SOLUTIONS USED FOR SPINAL ANESTHESIA Anesthesiology. 77: A898. DOI: 10.1097/00000542-199209001-00898  0.088
1990 Tbalhammer J, Raymond S, Popitz-Bergez F, Strichartz G. Activity-dependent modulation of axonal excitability is modality specific in cutaneous afferents Pain. 41: S464. DOI: 10.1016/0304-3959(90)93044-X  0.087
1978 Strichartz GR, Chiu SY, Ritchie JM. The effect of delta9-tetrahydrocannabinol on the activation of sodium conductance in node of Ranvier. The Journal of Pharmacology and Experimental Therapeutics. 207: 801-9. PMID 310454  0.087
1972 Strichartz GR, Chance B. Absorbance changes at 520 nm caused by salt addition to chloroplast suspensions in the dark. Biochimica Et Biophysica Acta. 256: 71-84. PMID 5009822 DOI: 10.1016/0005-2728(72)90164-8  0.087
1987 Bokesch PM, Raymond SA, Strichartz GR. Does the Duration of Anesthetic Administration Affect the Pharmacokinetics or Metabolism of Inhaled Anesthetics in Humans? Anesthesia & Analgesia. 66: 1???8. DOI: 10.1213/00000539-198701000-00001  0.085
1990 Strichartz GR. Lipids, pores, and excitable membranes Regional Anesthesia. 15: 3.  0.078
2014 Barr TP, Kornberg D, Montmayeur JP, Long M, Reichheld S, Strichartz GR. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. Analytical Biochemistry. 468: 28-33. PMID 25232999 DOI: 10.1016/J.Ab.2014.09.004  0.066
1996 Lambert DH, Lambert LA, Strichartz GR. Radicular irritation after spinal anesthesia. Anesthesiology. 85: 1216-7. PMID 8967608 DOI: 10.1097/00000542-199611000-00047  0.063
1989 Raymond SA, Strichartz GR. The long and short of differential block. Anesthesiology. 70: 725-8. PMID 2719304  0.057
2004 Lambert DH, Strichartz GR. In defense of in vitro findings. Anesthesiology. 101: 1246-7; author reply. PMID 15505475 DOI: 10.1097/00000542-200411000-00039  0.055
1997 Kohane DS, Yieh J, Langer R, Strichartz GR, Berde CB. A725 EPINEPHRINE MARKEDLY PROLONGS BLOCKADE FROM TETRODOTOXIN AND GREATLY CURTAILS ITS TOXICITY Anesthesiology. 87: 725A. DOI: 10.1097/00000542-199709001-00725  0.052
2015 Cassinello F, Prieto I, del Olmo M, Rivas S, Strichartz GR. Cancer surgery: how may anesthesia influence outcome? Journal of Clinical Anesthesia. 27: 262-72. PMID 25769963 DOI: 10.1016/j.jclinane.2015.02.007  0.048
1981 Strichartz GR. Natural Toxins. D. Eaker , T. Wadström The Quarterly Review of Biology. 56: 526-526. DOI: 10.1086/412572  0.037
1995 Strichartz GR, Lambert DH. Neurotoxicity of 5% lignocaine. British Journal of Anaesthesia. 75: 376. PMID 7547073  0.036
2019 Zeballos JL, Strichartz GR. Tuning Up the Life Saver: An Experimental Approach to Optimizing the Delivery of Intravenous Lipid Emulsions. Anesthesia and Analgesia. 128: 199-201. PMID 30649040 DOI: 10.1213/ANE.0000000000003863  0.028
1998 Lambert DH, Strichartz GR. Every problem is an opportunity, or one person's poison is another person's remedy. Regional Anesthesia and Pain Medicine. 23: 3-6. PMID 9552770  0.023
1993 Strichartz GR, Robotham JL. The control of vascular tone: Introductory comments Anesthesiology. 79: 1367.  0.017
1971 Strichartz GR. The Necessity for beta-Carotene in the 518 Nanometer Absorbance Change. Plant Physiology. 48: 553-8. PMID 16657837  0.011
2017 Strichartz GR. The Trip. Anesthesiology. PMID 28837435 DOI: 10.1097/ALN.0000000000001843  0.01
2001 Khodorova AB, Strichartz GR. Basic Science (26) Pain Practice. 1: 93-93. DOI: 10.1111/j.1533-2500.2001.1011-26.x  0.01
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