Kullervo Hynynen - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 

213 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jones RM, Kamps S, Huang Y, Scantlebury N, Lipsman N, Schwartz ML, Hynynen K. Accumulated thermal dose in MRI-guided focused ultrasound for essential tremor: repeated sonications with low focal temperatures. Journal of Neurosurgery. 1-8. PMID 31075781 DOI: 10.3171/2019.2.JNS182995  0.32
2019 Boutet A, Gwun D, Gramer R, Ranjan M, Elias GJB, Tilden D, Huang Y, Li SX, Davidson B, Lu H, Tyrrell P, Jones RM, Fasano A, Hynynen K, Kucharczyk W, et al. The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound. Journal of Neurosurgery. 1-7. PMID 31051458 DOI: 10.3171/2019.2.JNS182571  0.32
2019 Noroozian Z, Xhima K, Huang Y, Kaspar BK, Kügler S, Hynynen K, Aubert I. MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain. Methods in Molecular Biology (Clifton, N.J.). 1950: 177-197. PMID 30783974 DOI: 10.1007/978-1-4939-9139-6_10  0.56
2019 Mainprize T, Lipsman N, Huang Y, Meng Y, Bethune A, Ironside S, Heyn C, Alkins R, Trudeau M, Sahgal A, Perry J, Hynynen K. Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study. Scientific Reports. 9: 321. PMID 30674905 DOI: 10.1038/s41598-018-36340-0  0.32
2018 Meng Y, Solomon B, Boutet A, Llinas M, Scantlebury N, Huang Y, Hynynen K, Hamani C, Fasano A, Lozano AM, Lipsman N, Schwartz ML. Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30288794 DOI: 10.1002/mds.99  0.32
2018 Xhima K, Nabbouh F, Hynynen K, Aubert I, Tandon A. Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30264465 DOI: 10.1002/mds.101  0.56
2018 Poon CT, Shah K, Lin C, Tse R, Kim KK, Mooney S, Aubert I, Stefanovic B, Hynynen K. Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease. Scientific Reports. 8: 14061. PMID 30232364 DOI: 10.1038/s41598-018-32250-3  0.56
2018 Huang Y, Lipsman N, Schwartz ML, Krishna V, Sammartino F, Lozano AM, Hynynen K. Predicting Lesion Size by Accumulated Thermal Dose in MR-Guided Focused Ultrasound for Essential Tremor. Medical Physics. PMID 30098027 DOI: 10.1002/mp.13126  0.32
2018 O'Reilly MA, Hynynen K. Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain. Methods in Molecular Biology (Clifton, N.J.). 1831: 111-119. PMID 30051428 DOI: 10.1007/978-1-4939-8661-3_9  0.48
2018 Lipsman N, Meng Y, Bethune AJ, Huang Y, Lam B, Masellis M, Herrmann N, Heyn C, Aubert I, Boutet A, Smith GS, Hynynen K, Black SE. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nature Communications. 9: 2336. PMID 30046032 DOI: 10.1038/s41467-018-04529-6  0.56
2018 Foroozan F, O'Reilly MA, Hynynen K. Microbubble Localization for 3D Super-Resolution Ultrasound Imaging Using Curve Fitting and Deconvolution Methods. Ieee Transactions On Bio-Medical Engineering. PMID 29993387 DOI: 10.1109/TBME.2018.2813759  0.48
2018 O'Reilly MA, Chinnery T, Yee ML, Wu SK, Hynynen K, Kerbel RS, Czarnota GJ, Pritchard KI, Sahgal A. Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases. Scientific Reports. 8: 9013. PMID 29899537 DOI: 10.1038/s41598-018-27335-y  0.48
2018 Jones RM, Deng L, Leung K, McMahon D, O'Reilly MA, Hynynen K. Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening. Theranostics. 8: 2909-2926. PMID 29896293 DOI: 10.7150/thno.24911  0.48
2018 Hughes A, Huang Y, Schwartz ML, Hynynen K. The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor. Medical Physics. PMID 29758099 DOI: 10.1002/mp.12975  0.32
2018 Schwartz ML, Yeung R, Huang Y, Lipsman N, Krishna V, Jain JD, Chapman MG, Lozano AM, Hynynen K. Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures. Journal of Neurosurgery. 1-5. PMID 29726769 DOI: 10.3171/2017.11.JNS17968  0.32
2017 Meng Y, Huang Y, Solomon B, Hynynen K, Scantlebury N, Schwartz ML, Lipsman N. MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor. Journal of Visualized Experiments : Jove. PMID 29286434 DOI: 10.3791/56365  0.32
2017 Liu M, Jevtic S, Markham-Coultes K, Ellens NPK, O'Reilly MA, Hynynen K, Aubert I, McLaurin J. Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease. Brain Research. PMID 29066368 DOI: 10.1016/j.brainres.2017.10.015  0.56
2017 O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 7: 3573-3584. PMID 28912896 DOI: 10.7150/thno.20621  0.48
2017 Acconcia CN, Jones RM, Goertz DE, O'Reilly MA, Hynynen K. Megahertz rate, volumetric imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver array. Physics in Medicine and Biology. PMID 28786395 DOI: 10.1088/1361-6560/aa84d7  0.48
2017 Tam F, Huang Y, Schwartz ML, Schweizer TA, Hynynen K, Graham SJ. A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound. Bmc Neurology. 17: 74. PMID 28412948 DOI: 10.1186/s12883-017-0856-8  0.32
2017 Bushehri A, Czarnota G, Zhang L, Hynynen K, Huang Y, Chan M, Chu W, Dennis K, Mougenot C, Coccagna J, Sahgal A, Chow E, DeAngelis C. Urinary cytokines/chemokines after magnetic resonance-guided high intensity focused ultrasound for palliative treatment of painful bone metastases. Annals of Palliative Medicine. 6: 36-54. PMID 28209068 DOI: 10.21037/apm.2016.12.06  0.32
2017 O'Reilly MA, Hough O, Hynynen K. Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. PMID 28108988 DOI: 10.7863/ultra.16.02005  0.48
2016 Deng L, O'Reilly MA, Jones RM, An R, Hynynen K. A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping. Physics in Medicine and Biology. 61: 8476-8501. PMID 27845920 DOI: 10.1088/0031-9155/61/24/8476  0.48
2016 Hughes A, Huang Y, Pulkkinen A, Schwartz ML, Lozano AM, Hynynen K. A numerical study on the oblique focus in MR-guided transcranial focused ultrasound. Physics in Medicine and Biology. 61: 8025-8043. PMID 27779134 DOI: 10.1088/0031-9155/61/22/8025  0.32
2016 O'Reilly MA, Jones RM, Birman G, Hynynen K. Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array. Medical Physics. 43: 5063. PMID 27587036 DOI: 10.1118/1.4960362  0.48
2016 Hynynen K, Jones RM. Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy. Physics in Medicine and Biology. 61: R206-R248. PMID 27494561 DOI: 10.1088/0031-9155/61/17/R206  0.48
2016 Chan M, Dennis K, Huang Y, Mougenot C, Chow E, DeAngelis C, Coccagna J, Sahgal A, Hynynen K, Czarnota G, Chu W. Magnetic Resonance-Guided High-Intensity- Focused Ultrasound for Palliation of Painful Skeletal Metastases: A Pilot Study. Technology in Cancer Research & Treatment. PMID 27480322 DOI: 10.1177/1533034616658576  0.32
2016 Mooney SJ, Shah K, Yeung S, Burgess A, Aubert I, Hynynen K. Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability. Plos One. 11: e0159892. PMID 27459643 DOI: 10.1371/journal.pone.0159892  0.56
2016 Huang Y, Alkins R, Schwartz ML, Hynynen K. Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model. Radiology. 152154. PMID 27420647 DOI: 10.1148/radiol.2016152154  0.32
2016 Chu W, Staruch RM, Pichardo S, Tillander M, Köhler MO, Huang Y, Ylihautala M, McGuffin M, Czarnota G, Hynynen K. Magnetic Resonance-Guided High Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation. International Journal of Radiation Oncology, Biology, Physics. PMID 27209510 DOI: 10.1016/j.ijrobp.2016.03.019  0.32
2016 Alkins R, Burgess A, Kerbel R, Wels WS, Hynynen K. Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival. Neuro-Oncology. PMID 26819443 DOI: 10.1093/neuonc/nov318  0.48
2016 Burgess A, Hynynen K. Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System. Advances in Experimental Medicine and Biology. 880: 293-308. PMID 26486344 DOI: 10.1007/978-3-319-22536-4_16  0.48
2015 Ellens N, Hynynen K. Frequency considerations for deep ablation with high-intensity focused ultrasound: A simulation study. Medical Physics. 42: 4896-10. PMID 26233216 DOI: 10.1118/1.4927060  0.48
2015 Jones RM, O'Reilly MA, Hynynen K. Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections. Medical Physics. 42: 4385. PMID 26133635 DOI: 10.1118/1.4922677  0.48
2015 Oakden W, Kwiecien JM, O'Reilly MA, Dabrowski W, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ. Quantitative MRI in a non-surgical model of cervical spinal cord injury. Nmr in Biomedicine. PMID 26053102 DOI: 10.1002/nbm.3326  0.48
2015 Burgess A, Shah K, Hough O, Hynynen K. Focused ultrasound-mediated drug delivery through the blood-brain barrier. Expert Review of Neurotherapeutics. 15: 477-91. PMID 25936845 DOI: 10.1586/14737175.2015.1028369  0.48
2015 O'Reilly MA, Hynynen K. Emerging non-cancer applications of therapeutic ultrasound. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 31: 310-8. PMID 25792225 DOI: 10.3109/02656736.2015.1004375  0.48
2015 Weber-Adrian D, Thévenot E, O'Reilly MA, Oakden W, Akens MK, Ellens N, Markham-Coultes K, Burgess A, Finkelstein J, Yee AJ, Whyne CM, Foust KD, Kaspar BK, Stanisz GJ, Chopra R, ... Hynynen K, et al. Gene delivery to the spinal cord using MRI-guided focused ultrasound. Gene Therapy. 22: 568-77. PMID 25781651 DOI: 10.1038/gt.2015.25  0.56
2015 Staruch RM, Hynynen K, Chopra R. Hyperthermia-mediated doxorubicin release from thermosensitive liposomes using MR-HIFU: therapeutic effect in rabbit Vx2 tumours. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 31: 118-33. PMID 25582131 DOI: 10.3109/02656736.2014.992483  0.48
2015 Hosseinkhah N, Goertz DE, Hynynen K. Microbubbles and blood-brain barrier opening: a numerical study on acoustic emissions and wall stress predictions. Ieee Transactions On Bio-Medical Engineering. 62: 1293-304. PMID 25546853 DOI: 10.1109/TBME.2014.2385651  0.48
2015 Liu R, Huynh TJ, Huang Y, Ramsay D, Hynynen K, Aviv RI. Modeling the pattern of contrast extravasation in acute intracerebral hemorrhage using dynamic contrast-enhanced MR. Neurocritical Care. 22: 320-4. PMID 25260552 DOI: 10.1007/s12028-014-0071-z  0.48
2015 Burgess A, Hynynen K. Ultrasound-mediated drug delivery across the blood-brain barrier Advances in Non-Invasive Drug Delivery to the Brain. 112-127. DOI: 10.4155/9781909453937.FSEB2013.13.20  0.48
2015 Ellens N, Hynynen K. Frequency considerations for deep ablation with high-intensity focused ultrasound: A simulation study Medical Physics. 42: 4896-4910. DOI: 10.1118/1.4927060  0.48
2014 Nhan T, Burgess A, Lilge L, Hynynen K. Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability. Physics in Medicine and Biology. 59: 5987-6004. PMID 25230100 DOI: 10.1088/0031-9155/59/20/5987  0.48
2014 Burgess A, Dubey S, Yeung S, Hough O, Eterman N, Aubert I, Hynynen K. Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology. 273: 736-45. PMID 25222068 DOI: 10.1148/radiol.14140245  0.48
2014 Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K. Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 192: 243-8. PMID 25107692 DOI: 10.1016/j.jconrel.2014.07.051  0.48
2014 Pajek D, Burgess A, Huang Y, Hynynen K. High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power. Ultrasound in Medicine & Biology. 40: 2151-61. PMID 25023095 DOI: 10.1016/j.ultrasmedbio.2014.03.026  0.48
2014 Ellens N, Hynynen K. Simulation study of the effects of near- and far-field heating during focused ultrasound uterine fibroid ablation using an electronically focused phased array: A theoretical analysis of patient safety. Medical Physics. 41: 072902. PMID 24989412 DOI: 10.1118/1.4883777  0.48
2014 Oakden W, Kwiecien JM, O'Reilly MA, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ. A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles. Journal of Neuroscience Methods. 235: 92-100. PMID 24970578 DOI: 10.1016/j.jneumeth.2014.06.018  0.48
2014 Lipsman N, Mainprize TG, Schwartz ML, Hynynen K, Lozano AM. Intracranial applications of magnetic resonance-guided focused ultrasound. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 593-605. PMID 24850310 DOI: 10.1007/s13311-014-0281-2  0.48
2014 Aviv RI, Huynh T, Huang Y, Ramsay D, Van Slyke P, Dumont D, Asmah P, Alkins R, Liu R, Hynynen K. An in vivo, MRI-integrated real-time model of active contrast extravasation in acute intracerebral hemorrhage. Ajnr. American Journal of Neuroradiology. 35: 1693-9. PMID 24763419 DOI: 10.3174/ajnr.A3939  0.48
2014 O'Reilly MA, Jones RM, Hynynen K. Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array. Ieee Transactions On Bio-Medical Engineering. 61: 1285-94. PMID 24658252 DOI: 10.1109/TBME.2014.2300838  0.48
2014 Burgess A, Hynynen K. Drug delivery across the blood-brain barrier using focused ultrasound. Expert Opinion On Drug Delivery. 11: 711-21. PMID 24650132 DOI: 10.1517/17425247.2014.897693  0.48
2014 Scarcelli T, Jordão JF, O'Reilly MA, Ellens N, Hynynen K, Aubert I. Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice. Brain Stimulation. 7: 304-7. PMID 24629831 DOI: 10.1016/j.brs.2013.12.012  0.48
2014 Pulkkinen A, Werner B, Martin E, Hynynen K. Numerical simulations of clinical focused ultrasound functional neurosurgery. Physics in Medicine and Biology. 59: 1679-700. PMID 24619067 DOI: 10.1088/0031-9155/59/7/1679  0.48
2014 Leskinen JJ, Olkku A, Mahonen A, Hynynen K. Nonuniform temperature rise in in vitro osteoblast ultrasound exposures with associated bioeffect. Ieee Transactions On Bio-Medical Engineering. 61: 920-7. PMID 24557693 DOI: 10.1109/TBME.2013.2292546  0.48
2014 Diaz RJ, McVeigh PZ, O'Reilly MA, Burrell K, Bebenek M, Smith C, Etame AB, Zadeh G, Hynynen K, Wilson BC, Rutka JT. Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 1075-87. PMID 24374363 DOI: 10.1016/j.nano.2013.12.006  0.48
2014 Lanza GM, Moonen C, Baker JR, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, et al. Assessing the barriers to image-guided drug delivery. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 6: 1-14. PMID 24339356 DOI: 10.1002/wnan.1247  0.48
2014 Carias M, Hynynen K. The evaluation of steerable ultrasonic catheters for minimally invasive MRI-guided cardiac ablation. Magnetic Resonance in Medicine. 72: 591-8. PMID 24114767 DOI: 10.1002/mrm.24945  0.48
2014 O'Reilly MA, Jones RM, Hynynen K. Investigating a method for non-invasive ultrasound aberration correction through the skull bone Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9040. DOI: 10.1117/12.2043832  0.48
2014 Halani S, Coccagna J, Chow E, Hynynen K, Czarnota GJ. High-intensity focussed ultrasound and radio-frequency ablation for bone metastasis treatment Cancer Metastasis - Biology and Treatment. 21: 275-300. DOI: 10.1007/978-94-007-7569-5_14  0.48
2013 Nhan T, Burgess A, Hynynen K. Transducer design and characterization for dorsal-based ultrasound exposure and two-photon imaging of in vivo blood-brain barrier disruption in a rat model. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 60: 1376-85. PMID 25004505 DOI: 10.1109/TUFFC.2013.2710  0.48
2013 Pajek D, Hynynen K. The application of sparse arrays in high frequency transcranial focused ultrasound therapy: a simulation study. Medical Physics. 40: 122901. PMID 24320540 DOI: 10.1118/1.4829510  0.48
2013 O'Reilly MA, Hynynen K. A super-resolution ultrasound method for brain vascular mapping. Medical Physics. 40: 110701. PMID 24320408 DOI: 10.1118/1.4823762  0.48
2013 Alkins R, Huang Y, Pajek D, Hynynen K. Cavitation-based third ventriculostomy using MRI-guided focused ultrasound. Journal of Neurosurgery. 119: 1520-9. PMID 24074494 DOI: 10.3171/2013.8.JNS13969  0.48
2013 Nhan T, Burgess A, Cho EE, Stefanovic B, Lilge L, Hynynen K. Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 274-80. PMID 24008151 DOI: 10.1016/j.jconrel.2013.08.029  0.48
2013 Hosseinkhah N, Chen H, Matula TJ, Burns PN, Hynynen K. Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study. The Journal of the Acoustical Society of America. 134: 1875-85. PMID 23967921 DOI: 10.1121/1.4817843  0.48
2013 Jones RM, O'Reilly MA, Hynynen K. Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study. Physics in Medicine and Biology. 58: 4981-5005. PMID 23807573 DOI: 10.1088/0031-9155/58/14/4981  0.48
2013 Huang Y, Vykhodtseva NI, Hynynen K. Creating brain lesions with low-intensity focused ultrasound with microbubbles: a rat study at half a megahertz. Ultrasound in Medicine & Biology. 39: 1420-8. PMID 23743099 DOI: 10.1016/j.ultrasmedbio.2013.03.006  0.48
2013 Jordão JF, Thévenot E, Markham-Coultes K, Scarcelli T, Weng YQ, Xhima K, O'Reilly M, Huang Y, McLaurin J, Hynynen K, Aubert I. Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. Experimental Neurology. 248: 16-29. PMID 23707300 DOI: 10.1016/j.expneurol.2013.05.008  0.48
2013 Alkins RD, Brodersen PM, Sodhi RN, Hynynen K. Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound. Neuro-Oncology. 15: 1225-35. PMID 23640533 DOI: 10.1093/neuonc/not052  0.48
2013 Lipsman N, Schwartz ML, Huang Y, Lee L, Sankar T, Chapman M, Hynynen K, Lozano AM. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. The Lancet. Neurology. 12: 462-8. PMID 23523144 DOI: 10.1016/S1474-4422(13)70048-6  0.48
2013 Burgess A, Hynynen K. Noninvasive and targeted drug delivery to the brain using focused ultrasound. Acs Chemical Neuroscience. 4: 519-26. PMID 23379618 DOI: 10.1021/cn300191b  0.48
2013 Alkins R, Burgess A, Ganguly M, Francia G, Kerbel R, Wels WS, Hynynen K. Focused ultrasound delivers targeted immune cells to metastatic brain tumors. Cancer Research. 73: 1892-9. PMID 23302230 DOI: 10.1158/0008-5472.CAN-12-2609  0.48
2013 Lucht B, Hubbell A, Hynynen K. Contrast-enhanced transcranial two-dimensional ultrasound imaging using shear-mode conversion at low frequency. Ultrasound in Medicine & Biology. 39: 332-44. PMID 23245822 DOI: 10.1016/j.ultrasmedbio.2012.09.007  0.48
2013 Todorova M, Agache V, Mortazavi O, Chen B, Karshafian R, Hynynen K, Man S, Kerbel RS, Goertz DE. Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles. International Journal of Cancer. Journal International Du Cancer. 132: 2956-66. PMID 23225339 DOI: 10.1002/ijc.27977  0.48
2013 Burgess A, Huang Y, Querbes W, Sah DW, Hynynen K. Non-invasive delivery of small interfering rubonucleic acid for reduction of Huntingtin expression in the brain is achieved using focused ultrasound to disrupt the blood-brain barrier Proceedings of Meetings On Acoustics. 19. DOI: 10.1121/1.4800368  0.48
2013 Jones R, O'Reilly M, Hynynen K. Simulations of transcranial passive acoustic mapping with hemispherical sparse arrays using computed tomography-based aberration corrections Proceedings of Meetings On Acoustics. 19. DOI: 10.1121/1.4800018  0.48
2013 Burgess A, Eterman N, Aubert I, Hynynen K. Two-photon microscopy for real-time monitoring of focused ultrasoundmediated drug delivery to the brain in a mouse model of Alzheimer's disease Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8588. DOI: 10.1117/12.2002124  0.48
2013 Acconcia C, Leung BYC, Hynynen K, Goertz DE. Interactions between ultrasound stimulated microbubbles and fibrin clots Applied Physics Letters. 103. DOI: 10.1063/1.4816750  0.48
2012 Goertz DE, Todorova M, Mortazavi O, Agache V, Chen B, Karshafian R, Hynynen K. Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles. Plos One. 7: e52307. PMID 23284980 DOI: 10.1371/journal.pone.0052307  0.48
2012 Staruch RM, Ganguly M, Tannock IF, Hynynen K, Chopra R. Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 776-87. PMID 23153219 DOI: 10.3109/02656736.2012.736670  0.48
2012 Burgess A, Huang Y, Querbes W, Sah DW, Hynynen K. Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression. Journal of Controlled Release : Official Journal of the Controlled Release Society. 163: 125-9. PMID 22921802 DOI: 10.1016/j.jconrel.2012.08.012  0.48
2012 Burgess A, Huang Y, Waspe AC, Ganguly M, Goertz DE, Hynynen K. High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke. Plos One. 7: e42311. PMID 22870315 DOI: 10.1371/journal.pone.0042311  0.48
2012 Thévenot E, Jordão JF, O'Reilly MA, Markham K, Weng YQ, Foust KD, Kaspar BK, Hynynen K, Aubert I. Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Human Gene Therapy. 23: 1144-55. PMID 22838844 DOI: 10.1089/hum.2012.013  0.48
2012 Song J, Lucht B, Hynynen K. Large improvement of the electrical impedance of imaging and high-intensity focused ultrasound (HIFU) phased arrays using multilayer piezoelectric ceramics coupled in lateral mode. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 59: 1584-95. PMID 22828853 DOI: 10.1109/TUFFC.2012.2358  0.48
2012 Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K. Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma. Ultrasound in Medicine & Biology. 38: 1716-25. PMID 22818878 DOI: 10.1016/j.ultrasmedbio.2012.04.015  0.48
2012 Pajek D, Hynynen K. The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study. Physics in Medicine and Biology. 57: 4951-68. PMID 22800986 DOI: 10.1088/0031-9155/57/15/4951  0.48
2012 O'Reilly MA, Hynynen K. Ultrasound enhanced drug delivery to the brain and central nervous system. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 386-96. PMID 22621739 DOI: 10.3109/02656736.2012.666709  0.48
2012 Miller DL, Smith NB, Bailey MR, Czarnota GJ, Hynynen K, Makin IR. Overview of therapeutic ultrasound applications and safety considerations. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. 31: 623-34. PMID 22441920  0.48
2012 Staruch R, Chopra R, Hynynen K. Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery. Radiology. 263: 117-27. PMID 22438444 DOI: 10.1148/radiol.11111189  0.48
2012 O'Reilly MA, Waspe AC, Chopra R, Hynynen K. MRI-guided disruption of the blood-brain barrier using transcranial focused ultrasound in a rat model. Journal of Visualized Experiments : Jove. PMID 22433937 DOI: 10.3791/3555  0.48
2012 Leskinen JJ, Hynynen K. Study of factors affecting the magnitude and nature of ultrasound exposure with in vitro set-ups. Ultrasound in Medicine & Biology. 38: 777-94. PMID 22425382 DOI: 10.1016/j.ultrasmedbio.2012.01.019  0.48
2012 Wright C, Hynynen K, Goertz D. In vitro and in vivo high-intensity focused ultrasound thrombolysis. Investigative Radiology. 47: 217-25. PMID 22373533 DOI: 10.1097/RLI.0b013e31823cc75c  0.48
2012 Etame AB, Diaz RJ, O'Reilly MA, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound. Nanomedicine : Nanotechnology, Biology, and Medicine. 8: 1133-42. PMID 22349099 DOI: 10.1016/j.nano.2012.02.003  0.48
2012 O'Reilly MA, Hynynen K. Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. Radiology. 263: 96-106. PMID 22332065 DOI: 10.1148/radiol.11111417  0.48
2012 Hosseinkhah N, Hynynen K. A three-dimensional model of an ultrasound contrast agent gas bubble and its mechanical effects on microvessels. Physics in Medicine and Biology. 57: 785-808. PMID 22252221 DOI: 10.1088/0031-9155/57/3/785  0.48
2012 Etame AB, Diaz RJ, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurgical Focus. 32: E3. PMID 22208896 DOI: 10.3171/2011.10.FOCUS11252  0.48
2012 Wright CC, Hynynen K, Goertz DE. Pulsed focused ultrasound-induced displacements in confined in vitro blood clots. Ieee Transactions On Bio-Medical Engineering. 59: 842-51. PMID 22194235 DOI: 10.1109/TBME.2011.2180904  0.48
2012 Song J, Pulkkinen A, Huang Y, Hynynen K. Investigation of standing-wave formation in a human skull for a clinical prototype of a large-aperture, transcranial MR-guided focused ultrasound (MRgFUS) phased array: an experimental and simulation study. Ieee Transactions On Bio-Medical Engineering. 59: 435-44. PMID 22049360 DOI: 10.1109/TBME.2011.2174057  0.48
2012 Mei CS, Mulkern RV, Oshio K, Chen NK, Madore B, Panych LP, Hynynen K, McDannold NJ. Ultrafast 1D MR thermometry using phase or frequency mapping. Magma (New York, N.Y.). 25: 5-14. PMID 21800192 DOI: 10.1007/s10334-011-0272-9  0.48
2012 Burgess A, Cho EE, Shaffaf L, Nhan T, Poon C, Hynynen K. The use of two-photon microscopy to study the biological effects of focused ultrasound on the brain Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8226. DOI: 10.1117/12.908826  0.48
2012 Acconcia C, Leung B, Hynynen K, Goertz D. Investigating the interaction between acoustically stimulated microbubbles and fibrin clots Aip Conference Proceedings. 1503: 250-255. DOI: 10.1063/1.4769953  0.48
2012 Looi T, Waspe A, Mougenot C, Amaral J, Temple M, Hynynen K, Drake J. Porcine pilot study of MRI-guided HIFU treatment for neonatal intraventricular hemorrhage (IVH) Aip Conference Proceedings. 1503: 233-238. DOI: 10.1063/1.4769950  0.48
2012 Staruch R, Chopra R, Hynynen K. Investigations into the use of MRI-controlled focused ultrasound for hyperthermia-mediated drug delivery Aip Conference Proceedings. 1481: 362-367. DOI: 10.1063/1.4757362  0.48
2012 O'Reilly MA, Rahman S, Hynynen K. Cavitation monitoring and passive beamforming using a hemispherical random sparse array Aip Conference Proceedings. 1481: 271-275. DOI: 10.1063/1.4757347  0.48
2012 Curiel L, Hynynen K. In vivo localized harmonic motion imaging of VX2 tumors Aip Conference Proceedings. 1481: 64-69. DOI: 10.1063/1.4757312  0.48
2011 Staruch R, Chopra R, Hynynen K. MRI-controlled ultrasound thermal therapy. Ieee Pulse. 2: 39-47. PMID 25372968 DOI: 10.1109/MPUL.2011.942604  0.48
2011 Hynynen K. MRIgHIFU: a tool for image-guided therapeutics. Journal of Magnetic Resonance Imaging : Jmri. 34: 482-93. PMID 22896850 DOI: 10.1002/jmri.22649  0.48
2011 Burgess A, Aubert I, Hynynen K. Focused ultrasound: crossing barriers to treat Alzheimer's disease. Therapeutic Delivery. 2: 281-6. PMID 22833998 DOI: 10.4155/tde.11.5  0.48
2011 El-Desouki MM, Hynynen K. Driving circuitry for focused ultrasound noninvasive surgery and drug delivery applications. Sensors (Basel, Switzerland). 11: 539-56. PMID 22346589 DOI: 10.3390/s110100539  0.48
2011 Burgess A, Ayala-Grosso CA, Ganguly M, Jordão JF, Aubert I, Hynynen K. Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. Plos One. 6: e27877. PMID 22114718 DOI: 10.1371/journal.pone.0027877  0.48
2011 O'Reilly MA, Muller A, Hynynen K. Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies. Ultrasound in Medicine & Biology. 37: 1930-7. PMID 21925788 DOI: 10.1016/j.ultrasmedbio.2011.08.001  0.48
2011 Ellens N, Pulkkinen A, Song J, Hynynen K. The utility of sparse 2D fully electronically steerable focused ultrasound phased arrays for thermal surgery: a simulation study. Physics in Medicine and Biology. 56: 4913-32. PMID 21772081 DOI: 10.1088/0031-9155/56/15/017  0.48
2011 Pulkkinen A, Huang Y, Song J, Hynynen K. Simulations and measurements of transcranial low-frequency ultrasound therapy: skull-base heating and effective area of treatment. Physics in Medicine and Biology. 56: 4661-83. PMID 21734333 DOI: 10.1088/0031-9155/56/15/003  0.48
2011 Curiel L, Hynynen K. Localized harmonic motion imaging for focused ultrasound surgery targeting. Ultrasound in Medicine & Biology. 37: 1230-9. PMID 21683514 DOI: 10.1016/j.ultrasmedbio.2011.05.013  0.48
2011 Cho EE, Drazic J, Ganguly M, Stefanovic B, Hynynen K. Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1852-62. PMID 21505473 DOI: 10.1038/jcbfm.2011.59  0.48
2011 Tempany CM, McDannold NJ, Hynynen K, Jolesz FA. Focused ultrasound surgery in oncology: overview and principles. Radiology. 259: 39-56. PMID 21436096 DOI: 10.1148/radiol.11100155  0.48
2011 O'Reilly MA, Waspe AC, Ganguly M, Hynynen K. Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate. Ultrasound in Medicine & Biology. 37: 587-94. PMID 21376455 DOI: 10.1016/j.ultrasmedbio.2011.01.008  0.48
2011 Huang Y, Hynynen K. MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption. Methods in Molecular Biology (Clifton, N.J.). 711: 579-93. PMID 21279624 DOI: 10.1007/978-1-61737-992-5_30  0.48
2011 Staruch R, Chopra R, Hynynen K. Localised drug release using MRI-controlled focused ultrasound hyperthermia. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 27: 156-71. PMID 21158487 DOI: 10.3109/02656736.2010.518198  0.48
2011 Pichardo S, Sin VW, Hynynen K. Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls. Physics in Medicine and Biology. 56: 219-50. PMID 21149950 DOI: 10.1088/0031-9155/56/1/014  0.48
2011 Hurwitz MD, Hansen JL, Prokopios-Davos S, Manola J, Wang Q, Bornstein BA, Hynynen K, Kaplan ID. Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153. Cancer. 117: 510-6. PMID 20886629 DOI: 10.1002/cncr.25619  0.48
2011 Caissie A, Karshafian R, Hynynen K, Czarnota GJ. Ultrasound contrast microbubbles: In vivo imaging and potential therapeutic applications Nanoimaging. 267-291. DOI: 10.4032/9789814267915  0.48
2011 Pajek D, Hynynen K. Design of a focused ultrasound phased array for the treatment of stroke: A simulation study Ieee International Ultrasonics Symposium, Ius. 1653-1655. DOI: 10.1109/ULTSYM.2011.0411  0.48
2011 Burgess A, Ayala-Grosso CA, Ganguly M, Jordão J, Aubert I, Hynynen K. Delivery of stem cells to the brain using MRIgFUS Ieee International Ultrasonics Symposium, Ius. 13-16. DOI: 10.1109/ULTSYM.2011.0004  0.48
2011 O'Reilly MA, Huang Y, Hynynen K. Standing waves in small animal models investigating ultrasound disruption of the blood-brain barrier Aip Conference Proceedings. 1359: 301-305. DOI: 10.1063/1.3607922  0.48
2011 Wright C, Hynynen K, Goertz D. An investigation of high intensity focused ultrasound thrombolysis Aip Conference Proceedings. 1359: 246-250. DOI: 10.1063/1.3607913  0.48
2011 Staruch R, Chopra R, Hynynen K. Investigations into thermally mediated drug delivery using a preclinical system for MRI-guided focused ultrasound Aip Conference Proceedings. 1359: 163-167. DOI: 10.1063/1.3607899  0.48
2011 Liu S, Hosseinkhah N, Hynynen K. Temperature change from oscillating bubbles within a capillary network induced by focused ultrasound Aip Conference Proceedings. 1359: 91-96. DOI: 10.1063/1.3607888  0.48
2011 Vykhodtseva N, Huang Y, Hynynen K. Histological findings in the brain after focused ultrasound ablation combined with definity using parameters suited for transcranial application Aip Conference Proceedings. 1359: 67-72. DOI: 10.1063/1.3607884  0.48
2011 Hosseinkhah N, Hynynen K. The mechanical effects of ultrasound contrast agents on micro-vessels Aip Conference Proceedings. 1359: 61-66. DOI: 10.1063/1.3607883  0.48
2010 Jalali S, Huang Y, Dumont DJ, Hynynen K. Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. Bmc Neurology. 10: 114. PMID 21078165 DOI: 10.1186/1471-2377-10-114  0.48
2010 O'Reilly MA, Huang Y, Hynynen K. The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model. Physics in Medicine and Biology. 55: 5251-67. PMID 20720286 DOI: 10.1088/0031-9155/55/18/001  0.48
2010 Schad KC, Hynynen K. In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy. Physics in Medicine and Biology. 55: 4933-47. PMID 20693614 DOI: 10.1088/0031-9155/55/17/004  0.48
2010 Chopra R, Vykhodtseva N, Hynynen K. Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. Acs Chemical Neuroscience. 1: 391-398. PMID 20563295 DOI: 10.1021/cn9000445  0.48
2010 O'Reilly MA, Hynynen K. A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy. Ieee Transactions On Bio-Medical Engineering. 57: 2286-94. PMID 20515709 DOI: 10.1109/TBME.2010.2050483  0.48
2010 Jordão JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, McLaurin J, Hynynen K, Aubert I. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. Plos One. 5: e10549. PMID 20485502 DOI: 10.1371/journal.pone.0010549  0.48
2010 Goertz DE, Wright C, Hynynen K. Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound. Ultrasound in Medicine & Biology. 36: 916-24. PMID 20447757 DOI: 10.1016/j.ultrasmedbio.2010.03.005  0.48
2010 Olkku A, Leskinen JJ, Lammi MJ, Hynynen K, Mahonen A. Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells. Bone. 47: 320-30. PMID 20435172 DOI: 10.1016/j.bone.2010.04.604  0.48
2010 Klotz AR, Lindvere L, Stefanovic B, Hynynen K. Temperature change near microbubbles within a capillary network during focused ultrasound. Physics in Medicine and Biology. 55: 1549-61. PMID 20164536 DOI: 10.1088/0031-9155/55/6/001  0.48
2010 Hynynen K. Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International Journal of Hyperthermia 1987;3:21-35. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 26: 12-5. PMID 20100047 DOI: 10.3109/02656730903250582  0.48
2010 Hynynen K, Roemer R, Anhalt D, Johnson C, Xu ZX, Swindell W, Cetas T. A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments. 1987. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 26: 1-11. PMID 20100046 DOI: 10.3109/02656730903492916  0.48
2010 McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery. 66: 323-32; discussion 3. PMID 20087132 DOI: 10.1227/01.NEU.0000360379.95800.2F  0.48
2010 Heikkilä J, Curiel L, Hynynen K. Local harmonic motion monitoring of focused ultrasound surgery--a simulation model. Ieee Transactions On Bio-Medical Engineering. 57: 185-93. PMID 19822463 DOI: 10.1109/TBME.2009.2033465  0.48
2010 Hynynen K. MRI-guided focused ultrasound treatments. Ultrasonics. 50: 221-9. PMID 19818981 DOI: 10.1016/j.ultras.2009.08.015  0.48
2010 Pulkkinen A, Hynynen K. Computational aspects in high intensity ultrasonic surgery planning. Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society. 34: 69-78. PMID 19740625 DOI: 10.1016/j.compmedimag.2009.08.001  0.48
2010 Song J, Hynynen K. Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy. Ieee Transactions On Bio-Medical Engineering. 57: 124-33. PMID 19695987 DOI: 10.1109/TBME.2009.2028739  0.48
2010 Waspe AC, Chau A, Kukic A, Chopra R, Hynynen K. An MRI-compatible three-axis focused ultrasound system for performing drug delivery studies in small animal models Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7629. DOI: 10.1117/12.844253  0.48
2010 Song J, Wu P, Gunaseelan S, Kukic A, Hynynen K. Fabrication of one-dimensional linear diagnostic and therapeutic high intensity focused ultrasound (HIFU) phased-arrays using lateral-mode coupling method Proceedings - Ieee Ultrasonics Symposium. 1104-1107. DOI: 10.1109/ULTSYM.2010.5935973  0.48
2010 Song J, Huang Y, Hynynen K. Investigation of standing wave formation in a human calvarium using a large scale, transcranial MR guided focused ultrasound phased-array Proceedings - Ieee Ultrasonics Symposium. 2274-2277. DOI: 10.1109/ULTSYM.2010.5935960  0.48
2010 O'Reilly MA, Rahman S, Song J, Lucht B, Hynynen K. Design and construction of a passive receiver array for monitoringtranscranial focused ultrasound therapy Proceedings - Ieee Ultrasonics Symposium. 890-892. DOI: 10.1109/ULTSYM.2010.5935751  0.48
2010 Curiel L, Hynynen K. Localized harmonic motion imaging for Focused Ultrasound Surgery targetingand treatment outcome Proceedings - Ieee Ultrasonics Symposium. 459-462. DOI: 10.1109/ULTSYM.2010.5935729  0.48
2010 Liu S, Hosseinkhah N, Hynynen K. Temperature change of oscillating bubbles within a capillary network induced by focused ultrasound Proceedings - Ieee Ultrasonics Symposium. 1567-1570. DOI: 10.1109/ULTSYM.2010.5935631  0.48
2010 Pichardo S, Hynynen K. Multi-frequency characterization of speed of sound for longitudinal transmission on freshly excised human skulls Aip Conference Proceedings. 1215: 282-286. DOI: 10.1063/1.3367161  0.48
2010 Leskinen JJ, Hynynen K. Study of parameters affecting the level of ultrasound exposure with in vitro set-ups Aip Conference Proceedings. 1215: 273-276. DOI: 10.1063/1.3367158  0.48
2010 O'Reilly MA, Hynynen K. Feasibility of a PVDF receiver for monitoring of transcranial therapy Aip Conference Proceedings. 1215: 212-215. DOI: 10.1063/1.3367144  0.48
2010 Kukic A, Hynynen K. High power low impedance therapeutic intracavitary phased array Aip Conference Proceedings. 1215: 194-198. DOI: 10.1063/1.3367139  0.48
2010 Hynynen K. ISTU 2009 Proceedings - Preface Aip Conference Proceedings. 1215: xiii.  0.48
2009 Colucci V, Strichartz G, Jolesz F, Vykhodtseva N, Hynynen K. Focused ultrasound effects on nerve action potential in vitro. Ultrasound in Medicine & Biology. 35: 1737-47. PMID 19647923 DOI: 10.1016/j.ultrasmedbio.2009.05.002  0.48
2009 Huang Y, Curiel L, Kukic A, Plewes DB, Chopra R, Hynynen K. MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking. Medical Physics. 36: 2016-20. PMID 19610290 DOI: 10.1118/1.3120289  0.48
2009 Chopra R, Curiel L, Staruch R, Morrison L, Hynynen K. An MRI-compatible system for focused ultrasound experiments in small animal models. Medical Physics. 36: 1867-74. PMID 19544806 DOI: 10.1118/1.3115680  0.48
2009 Curiel L, Huang Y, Vykhodtseva N, Hynynen K. Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion. Physics in Medicine and Biology. 54: 3405-19. PMID 19436103 DOI: 10.1088/0031-9155/54/11/009  0.48
2009 Pichardo S, Hynynen K. New design for an endoesophageal sector- based array for the treatment of atrial fibrillation: a parametric simulation study. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 56: 600-12. PMID 19411218 DOI: 10.1109/TUFFC.2009.1076  0.48
2009 Hynynen K, Yin J. Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 56: 557-64. PMID 19411214 DOI: 10.1109/TUFFC.2009.1072  0.48
2009 Pilatou MC, Stewart EA, Maier SE, Fennessy FM, Hynynen K, Tempany CM, McDannold N. MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids. Journal of Magnetic Resonance Imaging : Jmri. 29: 404-11. PMID 19161196 DOI: 10.1002/jmri.21688  0.48
2009 Yousefi A, Goertz DE, Hynynen K. Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques. Ieee Transactions On Medical Imaging. 28: 763-74. PMID 19150789 DOI: 10.1109/TMI.2008.2012017  0.48
2009 Hynynen K. Macromolecular delivery across the blood-brain barrier. Methods in Molecular Biology (Clifton, N.J.). 480: 175-85. PMID 19085123 DOI: 10.1007/978-1-59745-429-2_13  0.48
2009 Curiel L, Chopra R, Hynynen K. In Vivo Monitoring of Focused Ultrasound Surgery Using Local Harmonic Motion Ultrasound in Medicine and Biology. 35: 65-78. PMID 18805626 DOI: 10.1016/j.ultrasmedbio.2008.07.001  0.48
2009 Goertz DE, Karshafian R, Hynynen K. Investigating the effects of pulsed low intensity ultrasound and microbubbles in mouse tumors Proceedings - Ieee Ultrasonics Symposium. DOI: 10.1109/ULTSYM.2009.5441935  0.48
2009 Song J, Hynynen K. Comparison of acoustic power calibration methods for therapeutic ultrasound transducers using PVDF membrane hydrophone, heterodyne laser vibrometery and radiation force measurements Proceedings - Ieee Ultrasonics Symposium. DOI: 10.1109/ULTSYM.2009.5441928  0.48
2009 Song J, Hynynen K. Accurate assessment of middle ear effusion by monitoring ultrasound reflections from a tympanic membrane Proceedings - Ieee Ultrasonics Symposium. DOI: 10.1109/ULTSYM.2009.5441743  0.48
2009 Matsuura N, Williams R, Gorelikov I, Chaudhuri J, Rowlands J, Hynynen K, Foster S, Burns P, Resnik N. Nanoparticle-loaded perfluorocarbon droplets for imaging and therapy Proceedings - Ieee Ultrasonics Symposium. DOI: 10.1109/ULTSYM.2009.5441495  0.48
2009 McDannold N, Treat L, Vykhodtseva N, Hynynen K. Targeted drug delivery in the brain via ultrasound-induced blood-brain barrier disruption Proceedings - 2009 Ieee International Symposium On Biomedical Imaging: From Nano to Macro, Isbi 2009. 750. DOI: 10.1109/ISBI.2009.5193156  0.48
2009 Alvarado PVY, Chang CY, Hynynen K. Design of a manipulator system for hemorrhage detection and treatment using high intensity focused ultrasound 2009 Ieee/Rsj International Conference On Intelligent Robots and Systems, Iros 2009. 4529-4534. DOI: 10.1109/IROS.2009.5354215  0.48
2009 Treat LH, Zhang Y, McDannold N, Hynynen K. Impact of focused ultrasound-enhanced drug delivery on survival in rats with glioma Aip Conference Proceedings. 1113: 443-447. DOI: 10.1063/1.3131468  0.48
2009 Song J, Hynynen K. A 1372-element large scale hemispherical ultrasound phased array transducer for noninvasive transcranial therapy Aip Conference Proceedings. 1113: 377-381. DOI: 10.1063/1.3131452  0.48
2009 Leskinen J, Olkku A, Lammi MJ, Mahonen A, Hynynen K. Ultrasound induced activation of cell signaling on human MG-63 osteoblastic cells Aip Conference Proceedings. 1113: 35-39. DOI: 10.1063/1.3131448  0.48
2009 Pichardo S, Hynynen K. New design for an endo-esophageal probe intended for the ablation of cardiac muscle in the left-atrium : A parametric simulation study Aip Conference Proceedings. 1113: 352-356. DOI: 10.1063/1.3131446  0.48
2009 Wachsmuth J, Chopr R, Hynynen K. Feasibility of transient image-guided blood-spinal cord barrier disruption Aip Conference Proceedings. 1113: 256-259. DOI: 10.1063/1.3131425  0.48
2009 Heikkilä J, Curiel L, Hynynen K. A simulation model for local harmonic motion monitoring of focused ultrasound surgery Aip Conference Proceedings. 1113: 190-194. DOI: 10.1063/1.3131411  0.48
2009 Wright C, Hynynen K, Goertz D. Investigating sonothrombolysis with high frequency ultrasound Aip Conference Proceedings. 1113: 154-158. DOI: 10.1063/1.3131403  0.48
2009 Matsuura N, Gorelikov I, Williams R, Wan K, Zhu S, Booth J, Burns P, Hynynen K, Rowlands JA. Nanoparticle-tagged perfluorocarbon droplets for medical imaging Materials Research Society Symposium Proceedings. 1140: 87-92.  0.48
2008 Leskinen JJ, Karjalainen HM, Olkku A, Hynynen K, Mahonen A, Lammi MJ. Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound. Biorheology. 45: 345-54. PMID 18836235 DOI: 10.3233/BIR-2008-0480  0.48
2008 McDannold N, Tempany C, Jolesz F, Hynynen K. Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids Journal of Magnetic Resonance Imaging. 28: 1026-1032. PMID 18821603 DOI: 10.1002/jmri.21506  0.48
2008 Heikkilä J, Hynynen K. Simulations of lesion detection using a combined phased array LHMI-technique Ultrasonics. 48: 568-573. PMID 18778843 DOI: 10.1016/j.ultras.2008.07.010  0.48
2008 Lánä́rd ZM, McDannold NJ, Fennessy FM, Stewart EA, Jolesz FA, Hynynen K, Tempany CMC. Uterine leiomyomas: MR imaging-guided focused ultrasound surgery-imaging predictors of success 1 Radiology. 249: 187-194. PMID 18695211 DOI: 10.1148/radiol.2491071600  0.48
2008 Vykhodtseva N, McDannold N, Hynynen K. Progress and problems in the application of focused ultrasound for blood-brain barrier disruption Ultrasonics. 48: 279-296. PMID 18511095 DOI: 10.1016/j.ultras.2008.04.004  0.48
2008 Hynynen K. Ultrasound for drug and gene delivery to the brain Advanced Drug Delivery Reviews. 60: 1209-1217. PMID 18486271 DOI: 10.1016/j.addr.2008.03.010  0.48
2008 Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, Bacskai BJ. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. Plos One. 3: e2175. PMID 18478109 DOI: 10.1371/journal.pone.0002175  0.48
2008 Sheikov N, McDannold N, Sharma S, Hynynen K. Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium Ultrasound in Medicine and Biology. 34: 1093-1104. PMID 18378064 DOI: 10.1016/j.ultrasmedbio.2007.12.015  0.48
2008 Abramowicz JS, Barnett SB, Duck FA, Edmonds PD, Hynynen KH, Ziskin MC. Fetal thermal effects of diagnostic ultrasound Journal of Ultrasound in Medicine. 27: 541-559. PMID 18359908  0.48
2008 Fowlkes JB, Abramowicz JS, Church CC, Holland CK, Miller DL, O'Brien WD, Sanghvi NT, Stratmeyer ME, Zachary JF, Deng CX, Harris GR, Herman BA, Hynynen KH, Merritt CRB, Thomenius KE, et al. American Institute of Ultrasound in Medicine consensus report on potential bioeffects of diagnostic ultrasound: Executive summary Journal of Ultrasound in Medicine. 27: 503-515. PMID 18359906 DOI: 10.1177/8756479310394986  0.48
2008 McDannold N, Vykhodtseva N, Hynynen K. Effects of Acoustic Parameters and Ultrasound Contrast Agent Dose on Focused-Ultrasound Induced Blood-Brain Barrier Disruption Ultrasound in Medicine and Biology. 34: 930-937. PMID 18294757 DOI: 10.1016/j.ultrasmedbio.2007.11.009  0.48
2008 McDannold N, Vykhodtseva N, Hynynen K. Blood-Brain Barrier Disruption Induced by Focused Ultrasound and Circulating Preformed Microbubbles Appears to Be Characterized by the Mechanical Index Ultrasound in Medicine and Biology. 34: 834-840. PMID 18207311 DOI: 10.1016/j.ultrasmedbio.2007.10.016  0.48
2008 Goertz DE, Wright C, Hynynen K. Contrast agent kinetics in the rabbit brain during exposure to focused ultrasound Proceedings - Ieee Ultrasonics Symposium. 2062-2065. DOI: 10.1109/ULTSYM.2008.0509  0.48
2008 Yousefi A, Hynynen K. Transcranial shear-mode ultrasound imaging: Characterization of point spread function and assessment of excitation techniques Proceedings - Ieee Ultrasonics Symposium. 1359-1362. DOI: 10.1109/ULTSYM.2008.0329  0.48
2008 Goertz DE, Karshafian R, Hynynen K. Antivascular effects of pulsed low intensity and microbubbles in mouse tumors Proceedings - Ieee Ultrasonics Symposium. 670-673. DOI: 10.1109/ULTSYM.2008.0161  0.48
2007 Curiel L, Chopra R, Hynynen K. Progress in multimodality imaging: Truly simultaneous ultrasound and magnetic resonance imaging Ieee Transactions On Medical Imaging. 26: 1740-1747. PMID 18092742 DOI: 10.1109/TMI.2007.903572  0.48
2007 Pichardo S, Hynynen K. Treatment of near-skull brain tissue with a focused device using shear-mode conversion: A numerical study Physics in Medicine and Biology. 52: 7313-7332. PMID 18065841 DOI: 10.1088/0031-9155/52/24/008  0.48
2007 McDannold N, Barnes AS, Rybicki FJ, Oshio K, Chen NK, Hynynen K, Mulkern RV. Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging. Magnetic Resonance in Medicine. 58: 1117-23. PMID 18046702 DOI: 10.1002/mrm.21322  0.48
2007 Tang SC, Clement GT, Hynynen K. A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 1772-1783. PMID 17941383 DOI: 10.1109/TUFFC.2007.461  0.48
2007 White PJ, Palchaudhuri S, Hynynen K, Clement GT. The effects of desiccation on skull bone sound speed in porcine models Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 1708-1710. PMID 17703676 DOI: 10.1109/TUFFC.2007.443  0.48
2007 Pichardo S, Hynynen K. Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: A numerical study Physics in Medicine and Biology. 52: 4923-4942. PMID 17671344 DOI: 10.1088/0031-9155/52/16/014  0.48
2007 Sassaroli E, Hynynen K. Cavitation Threshold of Microbubbles in Gel Tunnels by Focused Ultrasound Ultrasound in Medicine and Biology. 33: 1651-1660. PMID 17590501 DOI: 10.1016/j.ultrasmedbio.2007.04.018  0.48
2007 Kinoshita M, Hynynen K. Key factors that affect sonoporation efficiency in in vitro settings: The importance of standing wave in sonoporation Biochemical and Biophysical Research Communications. 359: 860-865. PMID 17568561 DOI: 10.1016/j.bbrc.2007.05.153  0.48
2007 Caulfield RE, Yin X, Juste J, Hynynen K. A novel phase assignment protocol and driving system for a high-density focused ultrasound array Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 793-801. PMID 17441588 DOI: 10.1109/TUFFC.2007.312  0.48
2007 Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound International Journal of Cancer. 121: 901-907. PMID 17437269 DOI: 10.1002/ijc.22732  0.48
2007 Curiel L, Chopra R, Hynynen K. Local harmonic motion for in vivo focused ultrasound surgery monitoring Proceedings - Ieee Ultrasonics Symposium. 1961-1964. DOI: 10.1109/ULTSYM.2007.493  0.48
2007 Pichardo S, Hynynen K. A 2D-array for transcranial ultrasound focusing using shear-mode conversion: A numerical study Proceedings - Ieee Ultrasonics Symposium. 1317-1320. DOI: 10.1109/ULTSYM.2007.331  0.48
2007 Chopra R, Goertz D, Curiel L, Hynynen K. Simultaneous contrast ultrasound and DCE MRI for improved breast tumour characterization: demonstration of technical feasibility Proceedings - Ieee Ultrasonics Symposium. 644-647. DOI: 10.1109/ULTSYM.2007.167  0.48
2007 McDannold N, Vykhodtseva N, Hynynen K. Use of ultrasound pulses combined with definity for targeted blood-brain barrier disruption Aip Conference Proceedings. 911: 547-553. DOI: 10.1063/1.2744328  0.48
2007 Vykhodtseva N, McDannold N, Hynynen K. Effects of high intensity focused ultrasound on the brain Aip Conference Proceedings. 911: 535-541. DOI: 10.1063/1.2744326  0.48
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