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Manel Esteller - Publications

Affiliations: 
2015- Cancer Epigenetics and Biology Program (PEBC Bellvitge Biomedical Research Institute 
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Year Citation  Score
2023 Siqueira E, Kim BH, Reser L, Chow R, Delaney K, Esteller M, Ross MM, Shabanowitz J, Hunt DF, Guil S, Ausiö J. Analysis of the interplay between MeCP2 and histone H1 during differentiation of human ReNCell neural progenitor cells. Epigenetics. 18: 2276425. PMID 37976174 DOI: 10.1080/15592294.2023.2276425  0.689
2023 Janin M, Davalos V, Esteller M. Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics. Cancer Metastasis Reviews. PMID 37369946 DOI: 10.1007/s10555-023-10120-3  0.347
2023 Waryah C, Cursons J, Foroutan M, Pflueger C, Wang E, Molania R, Sorolla A, Wallis C, Moses C, Glas I, Magalhães L, Thompson EW, Fearnley LG, Chaffer CL, Davis M, ... ... Esteller M, et al. Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2301802. PMID 37217832 DOI: 10.1002/advs.202301802  0.346
2023 Ortiz-Barahona V, Soler M, Davalos V, García-Prieto CA, Janin M, Setien F, Fernández-Rebollo I, Bech-Serra JJ, De La Torre C, Guil S, Villanueva A, Zhang PH, Yang L, Guarnacci M, Schumann U, ... ... Esteller M, et al. Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer. Molecular Cancer. 22: 83. PMID 37173708 DOI: 10.1186/s12943-023-01785-z  0.691
2023 Davalos V, Lovell CD, Von Itter R, Dolgalev I, Agrawal P, Baptiste G, Kahler DJ, Sokolova E, Moran S, Piqué L, Vega-Saenz de Miera E, Fontanals-Cirera B, Karz A, Tsirigos A, Yun C, ... ... Esteller M, et al. An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma. Nature Communications. 14: 1867. PMID 37015919 DOI: 10.1038/s41467-023-36967-2  0.313
2023 Noguera-Castells A, García-Prieto CA, Álvarez-Errico D, Esteller M. Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome. Epigenetics. 18: 2185742. PMID 36871255 DOI: 10.1080/15592294.2023.2185742  0.319
2023 Petazzi P, Jorge-Torres OC, Gomez A, Scognamiglio I, Serra-Musach J, Merkel A, Grases D, Xiol C, O'Callaghan M, Armstrong J, Esteller M, Guil S. Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects. International Journal of Molecular Sciences. 24. PMID 36674969 DOI: 10.3390/ijms24021453  0.687
2022 Davalos V, Esteller M. Cancer epigenetics in clinical practice. Ca: a Cancer Journal For Clinicians. PMID 36512337 DOI: 10.3322/caac.21765  0.35
2022 Guil S, Esteller M. PRC2 Loss and DNMT Inhibition Boost Viral Mimicry in Cancer. Cancer Discovery. 12: 2020-2022. PMID 36052503 DOI: 10.1158/2159-8290.CD-22-0733  0.674
2022 Casado-Pelaez M, Bueno-Costa A, Esteller M. Single cell cancer epigenetics. Trends in Cancer. PMID 35821003 DOI: 10.1016/j.trecan.2022.06.005  0.338
2022 Blecua P, Davalos V, de Villasante I, Merkel A, Musulen E, Coll-SanMartin L, Esteller M. Refinement of computational identification of somatic copy number alterations using DNA methylation microarrays illustrated in cancers of unknown primary. Briefings in Bioinformatics. PMID 35524475 DOI: 10.1093/bib/bbac161  0.312
2022 Garcia-Prieto CA, Álvarez-Errico D, Musulen E, Bueno-Costa A, N Vazquez B, Vaquero A, Esteller M. Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome. Epigenetics. 1-9. PMID 35297293 DOI: 10.1080/15592294.2022.2053816  0.328
2022 Rosselló-Tortella M, Bueno-Costa A, Martínez-Verbo L, Villanueva L, Esteller M. DNA methylation-associated dysregulation of transfer RNA expression in human cancer. Molecular Cancer. 21: 48. PMID 35151331 DOI: 10.1186/s12943-022-01532-w  0.316
2022 Merkel A, Esteller M. Experimental and Bioinformatic Approaches to Studying DNA Methylation in Cancer. Cancers. 14. PMID 35053511 DOI: 10.3390/cancers14020349  0.338
2022 Siqueira E, Obiols-Guardia A, Jorge-Torres OC, Oliveira-Mateos C, Soler M, Ramesh-Kumar D, Setién F, van Rossum D, Pascual-Alonso A, Xiol C, Ivan C, Shimizu M, Armstrong J, Calin GA, Pasterkamp RJ, ... Esteller M, et al. Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome. Molecular Therapy. Nucleic Acids. 27: 621-644. PMID 35036070 DOI: 10.1016/j.omtn.2021.12.030  0.693
2021 Soler M, Davalos V, Sánchez-Castillo A, Mora-Martinez C, Setién F, Siqueira E, Castro de Moura M, Esteller M, Guil S. The transcribed ultraconserved region uc.160+ enhances processing and A-to-I editing of the miR-376 cluster: hypermethylation improves glioma prognosis. Molecular Oncology. PMID 34665919 DOI: 10.1002/1878-0261.13121  0.682
2021 Llabata P, Torres-Diz M, Gomez A, Tomas-Daza L, Romero OA, Grego-Bessa J, Llinas-Arias P, Valencia A, Esteller M, Javierre BM, Zhang X, Sanchez-Cespedes M. MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34493659 DOI: 10.1073/pnas.2024824118  0.303
2021 Izquierdo AG, Boughanem H, Diaz-Lagares A, Arranz-Salas I, Esteller M, Tinahones FJ, Casanueva FF, Macias-Gonzalez M, Crujeiras AB. DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer. Epigenetics. 1-12. PMID 34311674 DOI: 10.1080/15592294.2021.1950991  0.321
2021 Esteller M. DNA methylation in cancer: From mouse to human and back again. Ebiomedicine. 68: 103393. PMID 34044220 DOI: 10.1016/j.ebiom.2021.103393  0.326
2021 Alvarez-Palomo AB, Requena-Osete J, Delgado-Morales R, Moreno-Manzano V, Grau-Bove C, Tejera AM, Otero MJ, Barrot C, Santos-Barriopedro I, Vaquero A, Mezquita-Pla J, Moran S, Naya CH, Garcia-Martínez I, Pérez FV, ... ... Esteller M, et al. A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair generating improved genetically stable human induced pluripotent stem cells. Stem Cells (Dayton, Ohio). PMID 33621399 DOI: 10.1002/stem.3358  0.736
2020 Ji X, Lin L, Shen S, Dong X, Chen C, Li Y, Zhu Y, Huang H, Chen J, Chen X, Wei L, He J, Duan W, Su L, Jiang Y, ... ... Esteller M, et al. Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients. Molecular Oncology. 14: 2759-2774. PMID 33448640 DOI: 10.1002/1878-0261.12785  0.345
2020 Ortiz-Barahona V, Joshi RS, Esteller M. Use of DNA Methylation Profiling in Translational Oncology. Seminars in Cancer Biology. PMID 33352265 DOI: 10.1016/j.semcancer.2020.12.011  0.37
2020 Monteagudo-Sánchez A, Hernandez Mora JR, Simon C, Burton A, Tenorio J, Lapunzina P, Clark S, Esteller M, Kelsey G, López-Siguero JP, de Nanclares GP, Torres-Padilla ME, Monk D. The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances. Nucleic Acids Research. PMID 33053156 DOI: 10.1093/nar/gkaa837  0.312
2020 Janin M, Esteller M. Epigenetic Awakening of Viral Mimicry in Cancer. Cancer Discovery. 10: 1258-1260. PMID 32873618 DOI: 10.1158/2159-8290.Cd-20-0947  0.401
2020 Simonet NG, Thackray JK, Vazquez BN, Ianni A, Espinosa-Alcantud M, Morales-Sanfrutos J, Hurtado-Bagès S, Sabidó E, Buschbeck M, Tischfield J, De La Torre C, Esteller M, Braun T, Olivella M, Serrano L, et al. SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1. Science Advances. 6: eaaz2590. PMID 32832656 DOI: 10.1126/Sciadv.Aaz2590  0.318
2020 Rosselló-Tortella M, Llinàs-Arias P, Sakaguchi Y, Miyauchi K, Davalos V, Setien F, Calleja-Cervantes ME, Piñeyro D, Martínez-Gómez J, Guil S, Joshi R, Villanueva A, Suzuki T, Esteller M. Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 32778592 DOI: 10.1073/Pnas.2003358117  0.742
2020 Oriol-Tordera B, Berdasco M, Llano A, Mothe B, Gálvez C, Martinez-Picado J, Carrillo J, Blanco J, Duran-Castells C, Ganoza C, Sanchez J, Clotet B, Calle ML, Sánchez-Pla A, Esteller M, et al. Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control. Plos Pathogens. 16: e1008678. PMID 32760119 DOI: 10.1371/Journal.Ppat.1008678  0.333
2020 Moron-Lopez S, Urrea V, Dalmau J, Lopez M, Puertas MC, Ouchi D, Gómez A, Passaes C, Mothe B, Brander C, Saez-Cirion A, Clotet B, Esteller M, Berdasco M, Martinez-Picado J. The genome-wide methylation profile of CD4+ T cells from HIV-infected individuals identifies distinct patterns associated with disease progression. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 32712664 DOI: 10.1093/Cid/Ciaa1047  0.326
2020 Ashour N, Angulo JC, González-Corpas A, Orea MJ, Lobo MVT, Colomer R, Colás B, Esteller M, Ropero S. Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: a Role Regulating Tumor Growth. International Journal of Molecular Sciences. 21. PMID 32630147 DOI: 10.3390/Ijms21134687  0.368
2020 Villanueva L, Álvarez-Errico D, Esteller M. The Contribution of Epigenetics to Cancer Immunotherapy. Trends in Immunology. PMID 32622854 DOI: 10.1016/J.It.2020.06.002  0.375
2020 Davalos V, Esteller M. Insights from the genetic and transcriptional characterization of a cancer of unknown primary (CUP). Embo Molecular Medicine. 12: e12685. PMID 32558182 DOI: 10.15252/Emmm.202012685  0.302
2020 Blecua P, Martinez-Verbo L, Esteller M. The DNA methylation landscape of hematological malignancies: an update. Molecular Oncology. PMID 32526054 DOI: 10.1002/1878-0261.12744  0.445
2020 Cossío FP, Esteller M, Berdasco M. Towards a more precise therapy in cancer: Exploring epigenetic complexity. Current Opinion in Chemical Biology. 57: 41-49. PMID 32480315 DOI: 10.1016/J.Cbpa.2020.04.008  0.381
2020 Joshi R, Castro De Moura M, Piñeyro D, Alvarez-Errico D, Arribas C, Esteller M. The DNA methylation landscape of human cancer organoids available at the American type culture collection. Epigenetics. 1-11. PMID 32396494 DOI: 10.1080/15592294.2020.1762398  0.452
2020 Conley BA, Staudt L, Takebe N, Wheeler DA, Wang L, Cardenas MF, Korchina V, Zenklusen JC, McShane LM, Tricoli JV, Williams PM, Lubensky I, O'Sullivan-Coyne G, Kohn E, Little RF, ... ... Esteller M, et al. The Exceptional Responders Initiative: Feasibility of A National Cancer Institute Pilot Study. Journal of the National Cancer Institute. PMID 32339229 DOI: 10.1093/Jnci/Djaa061  0.311
2020 Mattesen TB, Rasmussen MH, Sandoval J, Ongen H, Árnadóttir SS, Gladov J, Martinez-Cardus A, Castro de Moura M, Madsen AH, Laurberg S, Dermitzakis ET, Esteller M, Andersen CL, Bramsen JB. MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer. Nature Communications. 11: 2025. PMID 32332866 DOI: 10.1038/S41467-020-16000-6  0.43
2020 Kim-Wanner SZ, Assenov Y, Nair MB, Weichenhan D, Benner A, Becker N, Landwehr K, Kuner R, Sültmann H, Esteller M, Koch I, Lindner M, Meister M, Thomas M, Bieg M, et al. Genome-wide DNA methylation profiling in early stage I lung adenocarcinoma reveals predictive aberrant methylation in the promoter region of the long non-coding RNA PLUT - an exploratory study. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 32272161 DOI: 10.1016/J.Jtho.2020.03.023  0.352
2020 Janin M, Coll-SanMartin L, Esteller M. Disruption of the RNA modifications that target the ribosome translation machinery in human cancer. Molecular Cancer. 19: 70. PMID 32241281 DOI: 10.1186/S12943-020-01192-8  0.37
2020 Soriano-Tárraga C, Lazcano U, Giralt-Steinhauer E, Avellaneda-Gómez C, Ois Á, Rodríguez-Campello A, Cuadrado-Godia E, Gómez-González A, Fernández-Sanlés A, Elosua R, Fernández-Cadenas I, Cullell N, Montaner J, Moran S, Esteller M, et al. Identification of 20 novel loci associated with ischaemic stroke. Epigenome-wide association study. Epigenetics. 1-10. PMID 32202197 DOI: 10.1080/15592294.2020.1746507  0.332
2020 Zhang R, Chen C, Dong X, Shen S, Lai L, He J, You D, Lin L, Zhu Y, Huang H, Chen J, Wei L, Chen X, Li Y, Guo Y, ... ... Esteller M, et al. Independent validation of early-stage NSCLC prognostic scores incorporating epigenetic and transcriptional biomarkers with gene-gene interactions and main effects. Chest. PMID 32113923 DOI: 10.1016/J.Chest.2020.01.048  0.399
2020 Parra M, Baptista MJ, Genescà E, Llinàs-Arias P, Esteller M. Genetics and Epigenetics of Leukemia and Lymphoma: From Knowledge to Applications, Meeting Report of the Josep Carreras Leukaemia Research Institute. Hematological Oncology. PMID 32073154 DOI: 10.1002/Hon.2725  0.338
2020 Esteve-Puig R, Bueno-Costa A, Esteller M. Writers, readers and erasers of RNA modifications in cancer. Cancer Letters. 474: 127-137. PMID 31991154 DOI: 10.1016/J.Canlet.2020.01.021  0.421
2020 Pla H, Díaz-Lagares Á, Hernandez A, Oliveras G, Pérez-Bueno F, Esteller M, Puig T, Palomeras S, Viñas G. 69P TGFBI promoter methylation validation as an epigenetic biomarker for trastuzumab resistance in HER2+ breast cancer patients cohort Annals of Oncology. 31. DOI: 10.1016/J.Annonc.2020.03.203  0.377
2019 Bueno-Costa A, Piñeyro D, Soler M, Javierre BM, Raurell-Vila H, Subirana-Granés M, Pasquali L, Martinez-Climent JA, Esteller M. B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation. Leukemia. PMID 31719676 DOI: 10.1038/S41375-019-0643-1  0.386
2019 Ikemori R, Gabasa M, Duch P, Vizoso M, Bragado P, Arshakyan M, Luis IC, Marín A, Morán S, Castro M, Fuster G, Gea-Sorli S, Jauset T, Soucek L, Montuenga LM, ... Esteller M, et al. Epigenetic SMAD3 repression in tumor-associated fibroblasts impairs fibrosis and response to the antifibrotic drug nintedanib in lung squamous cell carcinoma. Cancer Research. PMID 31694906 DOI: 10.1158/0008-5472.Can-19-0637  0.354
2019 Fernández-Sanlés A, Sayols-Baixeras S, de Moura MC, Esteller M, Subirana I, Torres-Cuevas S, Pérez-Fernández S, Aslibekyan S, Marrugat J, Elosua R. Physical Activity and Genome-wide DNA Methylation: The REGICOR Study. Medicine and Science in Sports and Exercise. PMID 31652233 DOI: 10.1249/Mss.0000000000002174  0.381
2019 Martínez de Paz A, Khajavi L, Martin H, Claveria-Gimeno R, Tom Dieck S, Cheema MS, Sanchez-Mut JV, Moksa MM, Carles A, Brodie NI, Sheikh TI, Freeman ME, Petrotchenko EV, Borchers CH, Schuman EM, ... ... Esteller M, et al. MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2. Epigenetics & Chromatin. 12: 63. PMID 31601272 DOI: 10.1186/S13072-019-0298-1  0.714
2019 Jung H, Kim HS, Kim JY, Sun JM, Ahn JS, Ahn MJ, Park K, Esteller M, Lee SH, Choi JK. DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load. Nature Communications. 10: 4278. PMID 31537801 DOI: 10.1038/S41467-019-12159-9  0.414
2019 Oliveira-Mateos C, Sánchez-Castillo A, Soler M, Obiols-Guardia A, Piñeyro D, Boque-Sastre R, Calleja-Cervantes ME, Castro de Moura M, Martínez-Cardús A, Rubio T, Pelletier J, Martínez-Iniesta M, Herrero-Martín D, Tirado OM, Gentilella A, ... ... Esteller M, et al. The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition. Nature Communications. 10: 3979. PMID 31484926 DOI: 10.1038/S41467-019-11910-6  0.714
2019 Janin M, Ortiz-Barahona V, de Moura MC, Martínez-Cardús A, Llinàs-Arias P, Soler M, Nachmani D, Pelletier J, Schumann U, Calleja-Cervantes ME, Moran S, Guil S, Bueno-Costa A, Piñeyro D, Perez-Salvia M, ... ... Esteller M, et al. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. Acta Neuropathologica. PMID 31428936 DOI: 10.1007/S00401-019-02062-4  0.721
2019 Piqué L, Martinez de Paz A, Piñeyro D, Martínez-Cardús A, Castro de Moura M, Llinàs-Arias P, Setien F, Gomez-Miragaya J, Gonzalez-Suarez E, Sigurdsson S, Jonasson JG, Villanueva A, Vidal A, Davalos V, Esteller M. Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer. Oncogene. PMID 31409895 DOI: 10.1038/S41388-019-0936-X  0.407
2019 Gómez-Miragaya J, Morán S, Calleja-Cervantes ME, Collado-Solé A, Paré L, Gómez A, Serra V, Dobrolecki LE, Lewis MT, Diaz-Lagares A, Eroles P, Prat A, Esteller M, González-Suárez E. The altered transcriptome and DNA methylation profiles of docetaxel resistance in breast cancer PDX models. Molecular Cancer Research : McR. PMID 31320385 DOI: 10.1158/1541-7786.Mcr-19-0040  0.445
2019 Montal R, Andreu-Oller C, Bassaganyas L, Esteban-Fabró R, Moran S, Montironi C, Moeini A, Pinyol R, Peix J, Cabellos L, Villanueva A, Sia D, Mazzaferro V, Esteller M, Llovet JM. Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials. British Journal of Cancer. PMID 31285588 DOI: 10.1038/S41416-019-0513-7  0.305
2019 Majem B, Parrilla A, Jiménez C, Suárez-Cabrera L, Barber M, Marín A, Castellví J, Tamayo G, Moreno-Bueno G, Ponce J, Matias-Guiu X, Alameda F, Romero I, Sánchez JL, Pérez-Benavente A, ... ... Esteller M, et al. MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways. Oncogene. PMID 31278368 DOI: 10.1038/S41388-019-0860-0  0.352
2019 Palomeras S, Diaz-Lagares Á, Viñas G, Setien F, Ferreira HJ, Oliveras G, Crujeiras AB, Hernández A, Lum DH, Welm AL, Esteller M, Puig T. Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer. Breast Cancer Research : Bcr. 21: 79. PMID 31277676 DOI: 10.1186/S13058-019-1160-X  0.307
2019 Davalos V, Esteller M. Disruption of Long Noncoding RNAs Targets Cancer Hallmark Pathways in Lung Tumorigenesis. Cancer Research. 79: 3028-3030. PMID 31201165 DOI: 10.1158/0008-5472.Can-19-0910  0.411
2019 Kel A, Boyarskikh U, Stegmaier P, Leskov LS, Sokolov AV, Yevshin I, Mandrik N, Stelmashenko D, Koschmann J, Kel-Margoulis O, Krull M, Martínez-Cardús A, Moran S, Esteller M, Kolpakov F, et al. Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer. Bmc Bioinformatics. 20: 119. PMID 30999858 DOI: 10.1186/S12859-019-2687-7  0.425
2019 Fernández AF, Bayón GF, Urdinguio RG, Toraño EG, García MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Bueno C, ... ... Esteller M, et al. Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Research. 29: 710.2. PMID 30936177 DOI: 10.1101/Gr.249417.119  0.342
2019 Zhang R, Lai L, Dong X, He J, You D, Chen C, Lin L, Zhu Y, Huang H, Shen S, Wei L, Chen X, Guo Y, Liu L, Su L, ... ... Esteller M, et al. SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: An epigenomic-smoking interaction analysis. Molecular Oncology. PMID 30924596 DOI: 10.1002/1878-0261.12482  0.306
2019 Llinàs-Arias P, Rosselló-Tortella M, Lopez-Serra P, Pérez-Salvia M, Setién F, Marin S, Muñoz JP, Junza A, Capellades J, Calleja-Cervantes ME, Ferreira HJ, Castro de Moura M, Srbic M, Martínez-Cardús A, de la Torre C, ... ... Esteller M, et al. Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming. Jci Insight. 5. PMID 30843871 DOI: 10.1172/Jci.Insight.125888  0.382
2019 Monteagudo-Sánchez A, Sánchez-Delgado M, Mora JRH, Santamaría NT, Gratacós E, Esteller M, de Heredia ML, Nunes V, Choux C, Fauque P, de Nanclares GP, Anton L, Elovitz MA, Iglesias-Platas I, Monk D. Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction. Clinical Epigenetics. 11: 35. PMID 30808399 DOI: 10.1186/S13148-019-0630-4  0.383
2019 Pineda B, Diaz-Lagares A, Pérez-Fidalgo JA, Burgués O, González-Barrallo I, Crujeiras AB, Sandoval J, Esteller M, Lluch A, Eroles P. A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients. Clinical Epigenetics. 11: 33. PMID 30786922 DOI: 10.1186/S13148-019-0626-0  0.357
2019 Belhadj S, Moutinho C, Mur P, Setien F, Llinàs-Arias P, Perez-Salvia M, Pons T, Pineda M, Brunet J, Navarro M, Capellà G, Esteller M, Valle L. Germline variation in O-Methylguanine-DNA Methyltransferase (MGMT) as cause of hereditary colorectal cancer. Cancer Letters. PMID 30677446 DOI: 10.1016/J.Canlet.2019.01.019  0.346
2019 Zhang R, Lai L, He J, Chen C, You D, Duan W, Dong X, Zhu Y, Lin L, Shen S, Guo Y, Su L, Shafer A, Moran S, Fleischer T, ... ... Esteller M, et al. EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC. Epigenetics. PMID 30665327 DOI: 10.1080/15592294.2019.1573066  0.44
2019 Requena J, Alvarez-Palomo AB, Codina-Pascual M, Delgado-Morales R, Moran S, Esteller M, Sal M, Juan-Otero M, Boronat Barado A, Consiglio A, Addeleccia Bogle O, Wolvertang E, Ovchinnikov D, Alvarez I, Jaraquemada D, et al. Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signaling. Stem Cells (Dayton, Ohio). PMID 30664289 DOI: 10.1002/Stem.2966  0.741
2019 Berdasco M, Esteller M. Clinical epigenetics: seizing opportunities for translation. Nature Reviews. Genetics. 20: 109-127. PMID 30479381 DOI: 10.1038/S41576-018-0074-2  0.309
2019 Pasculli B, Barbano R, Rendina M, Fontana A, Copetti M, Valori VM, Morritti M, Maiello E, Fazio VM, Esteller M, Parrella P. Abstract 4904: High levels of microRNA-210-3p are associated with increased risk of disease progression in breast cancer patients treated with docetaxel Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4904  0.31
2019 Mattesen TB, Rasmussen MH, Sandoval J, Ongen H, Árnadóttir SS, Madsen AH, Laurberg S, Dermitzakis ET, Esteller M, Andersen CL, Bramsen JB. Abstract 466: A novel DNA methylation-based approach for molecular subtyping and improved prognostication of colorectal cancer using formalin-fixed and paraffin-embedded tissue Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-466  0.397
2019 Castillo AS, Mateos CO, Riera MS, Esteller M, Guil S. Abstract 1819: Non-coding RNAs as key players for understanding oncogenic pathways in ovarian cancer: Studying new therapeutic strategies Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1819  0.691
2019 Ikemori R, Gabasa M, Vizoso M, Duch P, Moran S, Gea-Sorli S, Bragado P, Jauset T, Esteller M, Soucek L, Monsó E, Peinado V, Fillat C, Hilberg F, Reguart N, et al. Abstract 1225: Aberrant SMAD3 signaling in tumor-associated fibroblasts modulates fibrosis and response to the anti-fibrotic drug nintedanib in non-small cell lung cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1225  0.31
2019 Meza GH, Felden Jv, Craig A, Sayols S, Portela A, Esteller M, Schwartz M, Mazzaferro V, Llovet J, Villanueva A. Abstract 474: Genome-wide DNA methylation profiling reveals novel candidate epigenetic gatekeepers in hepatocarcinogenesis Cancer Research. 79: 474-474. DOI: 10.1158/1538-7445.Am2019-474  0.416
2019 Ikemori R, Gabasa M, Vizoso M, Duch P, Moran S, Gea-Sorli S, Bragado P, Jauset T, Esteller M, Soucek L, Monsó E, Peinado V, Fillat C, Hilberg F, Reguart N, et al. OA08.07 Aberrant Epigenetic SMAD3 Signaling in Tumor-Associated Fibroblasts Modulates Fibrosis and Response to Nintedanib in NSCLC Journal of Thoracic Oncology. 14. DOI: 10.1016/J.Jtho.2019.08.452  0.302
2018 Ruiz de Garibay G, Herranz C, Llorente A, Boni J, Serra-Musach J, Mateo F, Aguilar H, Gómez-Baldó L, Petit A, Vidal A, Climent F, Hernández-Losa J, Cordero Á, González-Suárez E, Sánchez-Mut JV, ... Esteller M, et al. Correction: Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness. Plos One. 13: e0207586. PMID 30419005 DOI: 10.1371/Journal.Pone.0207586  0.688
2018 Collord G, Tarpey P, Kurbatova N, Martincorena I, Moran S, Castro M, Nagy T, Bignell G, Maura F, Young MD, Berna J, Tubio JMC, McMurran CE, Young AMH, Sanders M, ... ... Esteller M, et al. An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures. Scientific Reports. 8: 13537. PMID 30202034 DOI: 10.1038/S41598-018-31659-0  0.362
2018 Guo Y, Zhang R, Shen S, Wei Y, Salama SM, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Su L, Zhu Z, Staaf J, Helland Å, Esteller M, Christiani DC. DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 30185536 DOI: 10.1158/1055-9965.Epi-18-0454  0.405
2018 Huertas CS, Aviñó A, Kurachi C, Piqué A, Sandoval J, Eritja R, Esteller M, Lechuga LM. Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins. Biosensors & Bioelectronics. 120: 47-54. PMID 30144645 DOI: 10.1016/J.Bios.2018.08.027  0.424
2018 Duruisseaux M, Martínez-Cardús A, Calleja-Cervantes ME, Moran S, Castro de Moura M, Davalos V, Piñeyro D, Sanchez-Cespedes M, Girard N, Brevet M, Giroux-Leprieur E, Dumenil C, Pradotto M, Bironzo P, Capelletto E, ... ... Esteller M, et al. Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis. The Lancet. Respiratory Medicine. PMID 30100403 DOI: 10.1016/S2213-2600(18)30284-4  0.306
2018 Ferreira HJ, Davalos V, de Moura MC, Soler M, Perez-Salvia M, Bueno-Costa A, Setien F, Moran S, Villanueva A, Esteller M. Circular RNA CpG island hypermethylation-associated silencing in human cancer. Oncotarget. 9: 29208-29219. PMID 30018746 DOI: 10.18632/Oncotarget.25673  0.469
2018 Rosenquist R, Esteller M, Plass C. Introduction: Epigenetics in cancer. Seminars in Cancer Biology. PMID 29990621 DOI: 10.1016/J.Semcancer.2018.07.002  0.38
2018 Hernandez Mora JR, Tayama C, Sánchez-Delgado M, Monteagudo-Sánchez A, Hata K, Ogata T, Medrano J, Poo-Llanillo ME, Simón C, Moran S, Esteller M, Tenorio J, Lapunzina P, Kagami M, Monk D, et al. Characterization of parent-of-origin methylation using the Illumina Infinium MethylationEPIC array platform. Epigenomics. PMID 29962238 DOI: 10.2217/Epi-2017-0172  0.35
2018 Koelsche C, Mynarek M, Schrimpf D, Bertero L, Serrano J, Sahm F, Reuss DE, Hou Y, Baumhoer D, Vokuhl C, Flucke U, Petersen I, Brück W, Rutkowski S, Zambrano SC, ... ... Esteller M, et al. Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations. Acta Neuropathologica. PMID 29881993 DOI: 10.1007/S00401-018-1871-6  0.375
2018 Perez-Salvia M, Aldaba E, Vara Y, Fabre M, Ferrer C, Masdeu C, Zubia A, San Sebastian E, Otaegui D, Llinàs-Arias P, Rosselló-Tortella M, Berdasco M, Moutinho C, Setien F, Villanueva A, ... ... Esteller M, et al. In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma. Haematologica. PMID 29880608 DOI: 10.3324/Haematol.2018.189241  0.464
2018 Jorge-Torres OC, Szczesna K, Roa L, Casal C, Gonzalez-Somermeyer L, Soler M, Velasco CD, Martínez-San Segundo P, Petazzi P, Sáez MA, Delgado-Morales R, Fourcade S, Pujol A, Huertas D, Llobet A, ... ... Esteller M, et al. Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. Cell Reports. 23: 1665-1677. PMID 29742424 DOI: 10.1016/J.Celrep.2018.04.010  0.779
2018 Sanchez-Mut JV, Heyn H, Silva BA, Dixsaut L, Garcia-Esparcia P, Vidal E, Sayols S, Glauser L, Monteagudo-Sánchez A, Perez-Tur J, Ferrer I, Monk D, Schneider B, Esteller M, Gräff J. PM20D1 is a quantitative trait locus associated with Alzheimer's disease. Nature Medicine. PMID 29736028 DOI: 10.1038/S41591-018-0013-Y  0.783
2018 Capper D, Engel NW, Stichel D, Lechner M, Glöss S, Schmid S, Koelsche C, Schrimpf D, Niesen J, Wefers AK, Jones DTW, Sill M, Weigert O, Ligon KL, Olar A, ... ... Esteller M, et al. DNA methylation-based reclassification of olfactory neuroblastoma. Acta Neuropathologica. PMID 29730775 DOI: 10.1007/S00401-018-1854-7  0.419
2018 Crujeiras AB, Morcillo S, Diaz-Lagares A, Sandoval J, Castellano-Castillo D, Torres E, Hervas D, Moran S, Esteller M, Macias-Gonzalez M, Casanueva FF, Tinahones FJ. Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis. International Journal of Obesity (2005). PMID 29717273 DOI: 10.1038/S41366-018-0065-6  0.384
2018 Gallardo-Gómez M, Moran S, Páez de la Cadena M, Martínez-Zorzano VS, Rodríguez-Berrocal FJ, Rodríguez-Girondo M, Esteller M, Cubiella J, Bujanda L, Castells A, Balaguer F, Jover R, De Chiara L. A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples. Clinical Epigenetics. 10: 53. PMID 29686738 DOI: 10.1186/S13148-018-0487-Y  0.393
2018 Hanly DJ, Esteller M, Berdasco M. Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29685978 DOI: 10.1098/Rstb.2017.0074  0.404
2018 Shen S, Zhang R, Guo Y, Loehrer E, Wei Y, Zhu Y, Yuan Q, Moran S, Fleischer T, Bjaanaes MM, Karlsson A, Planck M, Staaf J, Helland Å, Esteller M, et al. A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer. Molecular Oncology. PMID 29656435 DOI: 10.1002/1878-0261.12204  0.377
2018 Riemens RJM, van den Hove DLA, Esteller M, Delgado-Morales R. Directing neuronal cell fate in vitro: Achievements and challenges. Progress in Neurobiology. 168: 42-68. PMID 29653249 DOI: 10.1016/J.Pneurobio.2018.04.003  0.768
2018 Wei Y, Liang J, Zhang R, Guo Y, Shen S, Su L, Lin X, Moran S, Helland Å, Bjaanæs MM, Karlsson A, Planck M, Esteller M, Fleischer T, Staaf J, et al. Epigenetic modifications inlysine demethylases associate with survival of early-stage NSCLC. Clinical Epigenetics. 10: 41. PMID 29619118 DOI: 10.1186/S13148-018-0474-3  0.332
2018 Moran S, Esteller M. Infinium DNA Methylation Microarrays on Formalin-Fixed, Paraffin-Embedded Samples. Methods in Molecular Biology (Clifton, N.J.). 1766: 83-107. PMID 29605848 DOI: 10.1007/978-1-4939-7768-0_5  0.379
2018 Ferreira HJ, Esteller M. CpG Islands in Cancer: Heads, Tails, and Sides. Methods in Molecular Biology (Clifton, N.J.). 1766: 49-80. PMID 29605847 DOI: 10.1007/978-1-4939-7768-0_4  0.497
2018 Ramalho-Carvalho J, Gonçalves CS, Graça I, Bidarra D, Pereira-Silva E, Salta S, Godinho MI, Gomez A, Esteller M, Costa BM, Henrique R, Jerónimo C. A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting. Clinical Epigenetics. 10: 40. PMID 29599847 DOI: 10.1186/S13148-018-0475-2  0.365
2018 Koelsche C, Hartmann W, Schrimpf D, Stichel D, Jabar S, Ranft A, Reuss DE, Sahm F, Jones DTW, Bewerunge-Hudler M, Trautmann M, Klingebiel T, Vokuhl C, Gessler M, Wardelmann E, ... ... Esteller M, et al. Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 29572501 DOI: 10.1038/S41379-018-0045-3  0.372
2018 Schlüter A, Sandoval J, Fourcade S, Díaz-Lagares A, Ruiz M, Casaccia P, Esteller M, Pujol A. Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation. Brain Pathology (Zurich, Switzerland). PMID 29476661 DOI: 10.1111/Bpa.12595  0.405
2018 Ferreira HJ, Esteller M. Non-coding RNAs, epigenetics, and cancer: tying it all together. Cancer Metastasis Reviews. PMID 29374363 DOI: 10.1007/S10555-017-9715-8  0.459
2018 Marcos-Villar L, Díaz-Colunga J, Sandoval J, Zamarreño N, Landeras-Bueno S, Esteller M, Falcón A, Nieto A. Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response. Scientific Reports. 8: 1230. PMID 29352168 DOI: 10.1038/S41598-018-19370-6  0.343
2018 De La Haba J, Guerrero-Zotano A, Perez-Fidalgo JA, Gonzalez Santiago S, Muñoz M, Andres R, Cruz Zambrano C, Moran Salama S, Lopez-Tarruella S, Quiroga Garcia V, Servitja S, Mele M, Alonso Soler S, Adamo B, Escudero MJ, ... ... Esteller M, et al. A phase II clinical trial to analyze olaparib response in patients with BRCA1 and/or BRCA2 promoter methylation with advanced breast cancer (GEICAM/2015-06 COMETA-Breast study). Journal of Clinical Oncology. 36: TPS1114-TPS1114. DOI: 10.1200/Jco.2018.36.15_Suppl.Tps1114  0.368
2018 Pineda B, Perez-Fidalgo JA, Díaz-Lagares A, Burgues O, Gonzalez-Barrallo I, Crujeiras AB, Sandoval J, Esteller M, Eroles P, Lluch A. DNA methylation as an epigenetic signature predictive of response to neodjuvant treatment in TNBC patients. Journal of Clinical Oncology. 36: e12658-e12658. DOI: 10.1200/Jco.2018.36.15_Suppl.E12658  0.379
2018 Bueno-Costa A, Piñeyro D, Soler M, Javierre BM, Martínez-Climent JA, Esteller M. Induced Transdifferentiation of Leukemia B-Cells to Macrophages Involves Reconfiguration of the DNA Methylome Blood. 132: 5115-5115. DOI: 10.1182/Blood-2018-99-111580  0.311
2018 Perez-Salvia M, Eneko A, Yosu V, Myriam F, Cristina F, Carme M, Aizpea Z, Eider SS, Dorleta O, Pere L, Margalida R, Maria B, Fernando S, Catia M, Alberto V, ... ... Esteller M, et al. Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia Blood. 132: 5383-5383. DOI: 10.1182/Blood-2018-99-111578  0.314
2017 Oleksiewicz U, Gładych M, Raman AT, Heyn H, Mereu E, Chlebanowska P, Andrzejewska A, Sozańska B, Samant N, Fąk K, Auguścik P, Kosiński M, Wróblewska JP, Tomczak K, Kulcenty K, ... ... Esteller M, et al. TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes. Stem Cell Reports. 9: 2065-2080. PMID 29198826 DOI: 10.1016/J.Stemcr.2017.10.031  0.448
2017 Bosch-Presegué L, Raurell-Vila H, Thackray JK, González J, Casal C, Kane-Goldsmith N, Vizoso M, Brown JP, Gómez A, Ausió J, Zimmermann T, Esteller M, Schotta G, Singh PB, Serrano L, et al. Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization. Cell Reports. 21: 2048-2057. PMID 29166597 DOI: 10.1016/J.Celrep.2017.10.092  0.31
2017 Aznar MA, Labiano S, Diaz-Lagares A, Molina C, Garasa S, Azpilicueta A, Etxeberria I, Sanchez-Paulete AR, Korman AJ, Esteller M, Sandoval J, Melero I. CD137 (4-1BB) costimulation modifies DNA methylation in CD8+ T-cell relevant genes. Cancer Immunology Research. PMID 29133290 DOI: 10.1158/2326-6066.Cir-17-0159  0.364
2017 Mathot P, Grandin M, Devailly G, Souaze F, Cahais V, Moran S, Campone M, Herceg Z, Esteller M, Juin P, Mehlen P, Dante R. DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment. Oncogenesis. 6: e390. PMID 29058695 DOI: 10.1038/oncsis.2017.88  0.389
2017 Barault L, Amatu A, Siravegna G, Ponzetti A, Moran S, Cassingena A, Mussolin B, Falcomatà C, Binder AM, Cristiano C, Oddo D, Guarrera S, Cancelliere C, Bustreo S, Bencardino K, ... ... Esteller M, et al. Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer. Gut. PMID 28982739 DOI: 10.1136/Gutjnl-2016-313372  0.436
2017 Izquierdo-Bouldstridge A, Bustillos A, Bonet-Costa C, Aribau-Miralbés P, García-Gomis D, Dabad M, Esteve-Codina A, Pascual-Reguant L, Peiró S, Esteller M, Murtha M, Millán-Ariño L, Jordan A. Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats. Nucleic Acids Research. PMID 28977426 DOI: 10.1093/Nar/Gkx746  0.302
2017 Llinàs-Arias P, Esteller M. Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update. Open Biology. 7. PMID 28931650 DOI: 10.1098/Rsob.170152  0.436
2017 Berdasco M, Gómez A, Rubio MJ, Català-Mora J, Zanón-Moreno V, Lopez M, Hernández C, Yoshida S, Nakama T, Ishikawa K, Ishibashi T, Boubekeur AM, Louhibi L, Pujana MA, Sayols S, ... ... Esteller M, et al. DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders. Scientific Reports. 7: 11762. PMID 28924151 DOI: 10.1038/S41598-017-12084-1  0.395
2017 Duruisseaux M, Esteller M. Lung cancer epigenetics: from knowledge to applications. Seminars in Cancer Biology. PMID 28919484 DOI: 10.1016/J.Semcancer.2017.09.005  0.378
2017 Martin-Trujillo A, Vidal E, Monteagudo-Sa Nchez A, Sanchez-Delgado M, Moran S, Hernandez Mora JR, Heyn H, Guitart M, Esteller M, Monk D. Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors. Nature Communications. 8: 467. PMID 28883545 DOI: 10.1038/S41467-017-00639-9  0.457
2017 Moutinho C, Esteller M. MicroRNAs and Epigenetics. Advances in Cancer Research. 135: 189-220. PMID 28882223 DOI: 10.1016/Bs.Acr.2017.06.003  0.369
2017 Pérez-Salvia M, Simó-Riudalbas L, Llinàs-Arias P, Roa L, Setien F, Soler M, de Moura MC, Bradner JE, Gonzalez-Suarez E, Moutinho C, Esteller M. Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer. Oncotarget. 8: 51621-51629. PMID 28881673 DOI: 10.18632/Oncotarget.18255  0.34
2017 Davalos V, Martinez-Cardus A, Esteller M. The Epigenomic Revolution in Breast Cancer: From Single-Gene to Genome-Wide Next-Generation Approaches. The American Journal of Pathology. PMID 28734945 DOI: 10.1016/J.Ajpath.2017.07.002  0.47
2017 Remacha L, Comino-Méndez I, Richter S, Contreras L, Currás-Freixes M, Pita G, Letón R, Galarreta A, Torres-Pérez R, Honrado E, Jiménez S, Maestre L, Moran S, Esteller M, Satrústegui J, et al. Targeted exome sequencing of Krebs cycle genes reveals candidate cancer predisposing mutations in pheochromocytomas and paragangliomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28720665 DOI: 10.1158/1078-0432.Ccr-16-2250  0.402
2017 Hernandez Mora JR, Sanchez-Delgado M, Petazzi P, Moran S, Esteller M, Iglesias-Platas I, Monk D. Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci. Epigenetics. 0. PMID 28678681 DOI: 10.1080/15592294.2017.1344803  0.418
2017 Moran S, Martinez-Cardús A, Boussios S, Esteller M. Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary. Nature Reviews. Clinical Oncology. PMID 28675165 DOI: 10.1038/Nrclinonc.2017.97  0.328
2017 Delgado-Morales R, Agís-Balboa RC, Esteller M, Berdasco M. Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders. Clinical Epigenetics. 9: 67. PMID 28670349 DOI: 10.1186/S13148-017-0365-Z  0.761
2017 Vidal E, Sayols S, Moran S, Guillaumet-Adkins A, Schroeder MP, Royo R, Orozco M, Gut M, Gut I, Lopez-Bigas N, Heyn H, Esteller M. A DNA methylation map of human cancer at single base-pair resolution. Oncogene. PMID 28581523 DOI: 10.1038/Onc.2017.176  0.482
2017 Wouters J, Vizoso M, Martinez-Cardus A, Carmona FJ, Govaere O, Laguna T, Joseph J, Dynoodt P, Aura C, Foth M, Cloots R, van den Hurk K, Balint B, Murphy IG, McDermott EW, ... ... Esteller M, et al. Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma. Bmc Medicine. 15: 101. PMID 28578692 DOI: 10.1186/S12916-017-0851-3  0.409
2017 Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, ... ... Esteller M, et al. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biology. 18: 98. PMID 28535802 DOI: 10.1186/S13059-017-1224-0  0.315
2017 Riemens RJM, Soares ES, Esteller M, Delgado-Morales R. Stem Cell Technology for (Epi)genetic Brain Disorders. Advances in Experimental Medicine and Biology. 978: 443-475. PMID 28523560 DOI: 10.1007/978-3-319-53889-1_23  0.764
2017 Bramsen JB, Rasmussen MH, Ongen H, Mattesen TB, Ørntoft MW, Árnadóttir SS, Sandoval J, Laguna T, Vang S, Øster B, Lamy P, Madsen MR, Laurberg S, Esteller M, Dermitzakis ET, et al. Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer. Cell Reports. 19: 1268-1280. PMID 28494874 DOI: 10.1016/J.Celrep.2017.04.045  0.333
2017 Crujeiras AB, Díaz-Lagares A, Stefansson OA, Macias M, Sandoval J, Cueva J, López-López R, Moran S, Jonasson JG, Tryggvadottir L, Olafsdottir E, Tinahones FJ, Carreira MC, Casanueva FF, Esteller M. Obesity and menopause modify the epigenomic profile of breast cancer. Endocrine-Related Cancer. PMID 28442560 DOI: 10.1530/Erc-16-0565  0.391
2017 Gimenez-Xavier P, Pros E, Bonastre E, Moran S, Aza A, Graña O, Gómez-López G, Derdak S, Dabad M, Esteve-Codina A, Hernandez Mora JR, Salinas-Chaparro D, Esteller M, Pisano D, Sanchez-Cespedes M. Genomic and molecular screenings identify different mechanisms for acquired resistance to MET inhibitors in lung cancer cells. Molecular Cancer Therapeutics. PMID 28396363 DOI: 10.1158/1535-7163.Mct-17-0104  0.388
2017 Anadón C, van Tetering G, Ferreira HJ, Moutinho C, Martínez-Cardús A, Villanueva A, Soler M, Heyn H, Moran S, de Moura MC, Setien F, Vidal A, Genescà E, Ribera JM, Nomdedeu JF, ... ... Esteller M, et al. Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia. Leukemia. PMID 28344317 DOI: 10.1038/Leu.2017.99  0.674
2017 Esteller M, Pandolfi PP. The Epitranscriptome of Noncoding RNAs in Cancer. Cancer Discovery. PMID 28320778 DOI: 10.1158/2159-8290.Cd-16-1292  0.402
2017 Ferreira HJ, Heyn H, Vizoso M, Moutinho C, Vidal E, Gomez A, Martínez-Cardús A, Simó-Riudalbas L, Moran S, Jost E, Esteller M. DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene. PMID 28288143 DOI: 10.1038/Onc.2017.57  0.416
2017 Moran S, Martínez-Cardús A, Esteller M. Journal club: epigenetic profiling to classify cancer of unknown primary - Authors' reply. The Lancet. Oncology. 18: e131. PMID 28271864 DOI: 10.1016/S1470-2045(17)30105-5  0.362
2017 Martín-Sánchez E, Mendaza S, Ulazia-Garmendia A, Monreal-Santesteban I, Blanco-Luquin I, Córdoba A, Vicente-García F, Pérez-Janices N, Escors D, Megías D, López-Serra P, Esteller M, Illarramendi JJ, Guerrero-Setas D. CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer. Oncotarget. PMID 28178655 DOI: 10.18632/Oncotarget.15004  0.409
2017 Ramalho-Carvalho J, Graça I, Gomez A, Oliveira J, Henrique R, Esteller M, Jerónimo C. Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer. Journal of Hematology & Oncology. 10: 43. PMID 28166834 DOI: 10.1186/S13045-017-0415-1  0.378
2017 Torres-Ferreira J, Ramalho-Carvalho J, Gomez A, Menezes FD, Freitas R, Oliveira J, Antunes L, Bento MJ, Esteller M, Henrique R, Jerónimo C. MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors. Molecular Cancer. 16: 26. PMID 28143614 DOI: 10.1186/S12943-017-0604-0  0.366
2017 Claveria-Gimeno R, Lanuza PM, Morales-Chueca I, Jorge-Torres OC, Vega S, Abian O, Esteller M, Velazquez-Campoy A. The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site. Scientific Reports. 7: 41635. PMID 28139759 DOI: 10.1038/Srep41635  0.342
2017 Sanchez-Mut JV, Heyn H, Vidal E, Delgado-Morales R, Moran S, Sayols S, Sandoval J, Ferrer I, Esteller M, Gräff J. Whole Genome Grey and White matter DNA Methylation Profiles in Dorsolateral Prefrontal cortex. Synapse (New York, N.Y.). PMID 28105729 DOI: 10.1002/Syn.21959  0.797
2017 Delgado-Morales R, Esteller M. Opening up the DNA methylome of dementia. Molecular Psychiatry. 22: 485-496. PMID 28044062 DOI: 10.1038/Mp.2016.242  0.764
2017 Pique L, Ferrerira HJ, Esteller M. Abstract 484: Epigenetic regulation of hsa-miR-3663 in colon cancer Cancer Research. 77: 484-484. DOI: 10.1158/1538-7445.Am2017-484  0.398
2017 Boque-Sastre R, Moura MCd, Gomez A, Guil S, Esteller M. Abstract 3483: Genome-wide analysis of the antisense transcriptome in cancer Cancer Research. 77: 3483-3483. DOI: 10.1158/1538-7445.Am2017-3483  0.692
2017 Palomeras S, Díaz Lagares Á, Blancafort A, Sarrats A, Crujeiras Martinez A, Sandoval J, Rabionet M, Welm A, Esteller M, Puig T. DNA methylation signature to identify trastuzumab response in HER2 breast cancer models Annals of Oncology. 28: i12. DOI: 10.1093/Annonc/Mdx138.010  0.388
2017 Ikemori R, Vizoso M, Puig M, Labernardie A, Gabasa M, Trepat X, Reguart N, Esteller M, Alcaraz J. P1.02-076 DNA Methylation Profiling Unravels a TGF-β Hyperresponse in Tumor Associated Fibroblasts from Lung Cancer Patients Journal of Thoracic Oncology. 12: S534-S535. DOI: 10.1016/J.Jtho.2016.11.660  0.383
2016 Murtha M, Esteller M. Extraordinary Cancer Epigenomics: Thinking Outside the Classical Coding and Promoter Box. Trends in Cancer. 2: 572-584. PMID 28741488 DOI: 10.1016/J.Trecan.2016.08.004  0.36
2016 Niu N, Liu T, Cairns J, Ly RC, Tan X, Deng M, Fridley BL, Kalari KR, Abo RP, Jenkins G, Batzler A, Carlson EE, Barman P, Moran S, Heyn H, ... Esteller M, et al. Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines. Human Molecular Genetics. 25: 4819-4834. PMID 28173075 DOI: 10.1093/Hmg/Ddw301  0.43
2016 Jordà M, Díez-Villanueva A, Mallona I, Martín B, Lois S, Barrera V, Esteller M, Vavouri T, Peinado MA. The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells. Genome Research. PMID 27999094 DOI: 10.1101/Gr.207522.116  0.436
2016 Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, ... ... Esteller M, et al. Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Oncogene. PMID 27991928 DOI: 10.1038/Onc.2016.427  0.746
2016 Reinhold WC, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn KW, Stevenson H, Wang Y, Heyn H, Nogales V, Moran S, Goldstein DJ, Doroshow JH, Meltzer PS, Esteller M, et al. The NCI-60 Methylome and its Integration into CellMiner. Cancer Research. PMID 27923837 DOI: 10.1158/0008-5472.Can-16-0655  0.462
2016 Pérez-Salvia M, Esteller M. Bromodomain Inhibitors and Cancer Therapy: From Structures to Applications. Epigenetics. 0. PMID 27911230 DOI: 10.1080/15592294.2016.1265710  0.408
2016 Huertas-Martínez J, Court F, Rello-Varona S, Herrero-Martín D, Almacellas-Rabaiget O, Sáinz-Jaspeado M, Garcia-Monclús S, Lagares-Tena L, Buj R, Hontecillas-Prieto L, Sastre A, Azorin D, Sanjuan X, López-Alemany R, Moran S, ... ... Esteller M, et al. DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with Caveolin-1. Cancer Letters. PMID 27894957 DOI: 10.1016/J.Canlet.2016.11.020  0.444
2016 Diaz-Lagares A, Crujeiras AB, Lopez-Serra P, Soler M, Setien F, Goyal A, Sandoval J, Hashimoto Y, Martinez-Cardús A, Gomez A, Heyn H, Moutinho C, Espada J, Vidal A, Paúles M, ... ... Esteller M, et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821766 DOI: 10.1073/Pnas.1608585113  0.748
2016 Azagra A, Román-González L, Collazo O, Rodríguez-Ubreva J, de Yébenes VG, Barneda-Zahonero B, Rodríguez J, Castro de Moura M, Grego-Bessa J, Fernández-Duran I, Islam AB, Esteller M, Ramiro AR, Ballestar E, Parra M. In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development. The Journal of Experimental Medicine. PMID 27810920 DOI: 10.1084/Jem.20150821  0.348
2016 Alelú-Paz R, Carmona FJ, Sanchez-Mut JV, Cariaga-Martínez A, González-Corpas A, Ashour N, Orea MJ, Escanilla A, Monje A, Guerrero Márquez C, Saiz-Ruiz J, Esteller M, Ropero S. Epigenetics in Schizophrenia: A Pilot Study of Global DNA Methylation in Different Brain Regions Associated with Higher Cognitive Functions. Frontiers in Psychology. 7: 1496. PMID 27746755 DOI: 10.3389/Fpsyg.2016.01496  0.757
2016 Vaclová T, Woods NT, Megías D, Gomez-Lopez S, Setién F, García Bueno JM, Macías JA, Barroso A, Urioste M, Esteller M, Monteiro AN, Benítez J, Osorio A. Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor Olaparib by a dominant negative effect. Human Molecular Genetics. PMID 27742776 DOI: 10.1093/Hmg/Ddw343  0.331
2016 Niu N, Liu T, Cairns J, Ly RC, Tan X, Deng M, Fridley BL, Kalari KR, Abo RP, Jenkins G, Batzler A, Carlson EE, Barman P, Moran S, Heyn H, ... Esteller M, et al. Metformin Pharmacogenomics: A genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines. Human Molecular Genetics. PMID 27616566 DOI: 10.1093/hmg/ddw301  0.317
2016 Romero OA, Verdura S, Torres-Diz M, Gomez A, Moran S, Condom E, Esteller M, Villanueva A, Sanchez-Cespedes M. Sensitization of retinoids and corticoids to epigenetic drugs in MYC-activated lung cancers by antitumor reprogramming. Oncogene. PMID 27593925 DOI: 10.1038/Onc.2016.296  0.35
2016 Moran S, Martínez-Cardús A, Sayols S, Musulén E, Balañá C, Estival-Gonzalez A, Moutinho C, Heyn H, Diaz-Lagares A, de Moura MC, Stella GM, Comoglio PM, Ruiz-Miró M, Matias-Guiu X, Pazo-Cid R, ... ... Esteller M, et al. Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. The Lancet. Oncology. PMID 27575023 DOI: 10.1016/S1470-2045(16)30297-2  0.392
2016 Serra-Musach J, Mateo F, Capdevila-Busquets E, de Garibay GR, Zhang X, Guha R, Thomas CJ, Grueso J, Villanueva A, Jaeger S, Heyn H, Vizoso M, Pérez H, Cordero A, Gonzalez-Suarez E, ... Esteller M, et al. Cancer network activity associated with therapeutic response and synergism. Genome Medicine. 8: 88. PMID 27553366 DOI: 10.1186/S13073-016-0340-X  0.319
2016 Martínez-Cardús A, Moran S, Musulen E, Moutinho C, Manzano JL, Martinez-Balibrea E, Tierno M, Élez E, Landolfi S, Lorden P, Arribas C, Müller F, Bock C, Tabernero J, Esteller M. Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-free and Overall Survival Times for Patients With Loco-regional Cancer. Gastroenterology. PMID 27521480 DOI: 10.1053/J.Gastro.2016.08.001  0.368
2016 Crujeiras AB, Diaz-Lagares A, Moreno-Navarrete JM, Sandoval J, Hervas D, Gomez A, Ricart W, Casanueva FF, Esteller M, Fernandez-Real JM. Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27477082 DOI: 10.1016/J.Trsl.2016.07.002  0.33
2016 Toll A, Salgado R, Espinet B, Díaz-Lagares A, Hernández-Ruiz E, Andrades E, Sandoval J, Esteller M, Pujol RM, Hernández-Muñoz I. MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression. Molecular Cancer. 15: 53. PMID 27457246 DOI: 10.1186/S12943-016-0537-Z  0.304
2016 Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, ... ... Esteller M, et al. A Landscape of Pharmacogenomic Interactions in Cancer. Cell. PMID 27397505 DOI: 10.1016/J.Cell.2016.06.017  0.399
2016 Ter Brugge P, Kristel P, van der Burg E, Boon U, de Maaker M, Lips E, Mulder L, de Ruiter J, Moutinho C, Gevensleben H, Marangoni E, Majewski I, Jóźwiak K, Kloosterman W, van Roosmalen M, ... ... Esteller M, et al. Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer. Journal of the National Cancer Institute. 108. PMID 27381626 DOI: 10.1093/Jnci/Djw148  0.345
2016 Anadón C, Guil S, Simó-Riudalbas L, Moutinho C, Setien F, Martínez-Cardús A, Moran S, Villanueva A, Calaf M, Vidal A, Lazo PA, Zondervan I, Savola S, Kohno T, Yokota J, ... ... Esteller M, et al. Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. Oncogene. PMID 27345394 DOI: 10.1038/Onc.2016.27  0.728
2016 de la Rocha C, Pérez-Mojica JE, León SZ, Cervantes-Paz B, Tristán-Flores FE, Rodríguez-Ríos D, Molina-Torres J, Ramírez-Chávez E, Alvarado-Caudillo Y, Carmona FJ, Esteller M, Hernández-Rivas R, Wrobel K, Wrobel K, Zaina S, et al. Associations between whole peripheral blood fatty acids and DNA methylation in humans. Scientific Reports. 6: 25867. PMID 27181711 DOI: 10.1038/Srep25867  0.397
2016 Silva-Martínez GA, Rodríguez-Ríos D, Alvarado-Caudillo Y, Vaquero A, Esteller M, Carmona FJ, Moran S, Nielsen FC, Wickström-Lindholmx M, Wrobel K, Wrobel K, Barbosa-Sabanero G, Zaina S, Lund G. Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 0. PMID 27088456 DOI: 10.1080/15592294.2016.1161873  0.409
2016 Villalba M, Diaz-Lagares A, Redrado M, de Aberasturi AL, Segura V, Bodegas ME, Pajares MJ, Pio R, Freire J, Gomez-Roman J, Montuenga LM, Esteller M, Sandoval J, Calvo A. Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients. Oncotarget. PMID 26989022 DOI: 10.18632/Oncotarget.8045  0.418
2016 Nuñez O, Román A, Johnson SR, Inoue Y, Hirose M, Casanova Á, de Garibay GR, Herranz C, Bueno-Moreno G, Boni J, Mateo F, Petit A, Climent F, Soler T, Vidal A, ... ... Esteller M, et al. Study of breast cancer incidence in patients of lymphangioleiomyomatosis. Breast Cancer Research and Treatment. PMID 26951504 DOI: 10.1007/S10549-016-3737-8  0.71
2016 Amatu A, Barault L, Moutinho C, Cassingena A, Bencardino K, Ghezzi S, Palmeri L, Bonazzina E, Tosi F, Ricotta R, Cipani T, Crivori P, Gatto R, Chirico G, Marrapese G, ... ... Esteller M, et al. Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. PMID 26916096 DOI: 10.1093/Annonc/Mdw071  0.337
2016 Diaz-Lagares A, Mendez-Gonzalez J, Hervas D, Saigi M, Pajares MJ, Garcia D, Crujeiras AB, Pio R, Montuenga LM, Zulueta J, Nadal E, Rosell A, Esteller M, Sandoval Del Amor J. A novel epigenetic signature for early diagnosis in lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26842235 DOI: 10.1158/1078-0432.Ccr-15-2346  0.328
2016 Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S, ... ... Esteller M, et al. Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nature Genetics. 48: 221. PMID 26813765 DOI: 10.1038/Ng0216-221  0.301
2016 Heyn H, Vidal E, Ferreira HJ, Vizoso M, Sayols S, Gomez A, Moran S, Boque-Sastre R, Guil S, Martinez-Cardus A, Lin CY, Royo R, Sanchez-Mut JV, Martinez R, Gut M, ... ... Esteller M, et al. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer. Genome Biology. 17: 11. PMID 26813288 DOI: 10.1186/S13059-016-0879-2  0.829
2016 Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R, Schultz MD, Ansoleaga B, Garcia-Esparcia P, Pons-Espinal M, de Lagran MM, Dopazo J, Rabano A, Avila J, Dierssen M, ... ... Esteller M, et al. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Translational Psychiatry. 6: e718. PMID 26784972 DOI: 10.1038/Tp.2015.214  0.812
2016 Royo F, Zuñiga-Garcia P, Torrano V, Loizaga A, Sanchez-Mosquera P, Ugalde-Olano A, González E, Cortazar AR, Palomo L, Fernández-Ruiz S, Lacasa-Viscasillas I, Berdasco M, Sutherland JD, Barrio R, Zabala-Letona A, ... ... Esteller M, et al. Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer. Oncotarget. PMID 26771841 DOI: 10.18632/Oncotarget.6899  0.313
2016 Diaz-Lagares A, Mendez-Gonzalez J, Hervas D, Saigi M, Pajares M, Garcia D, Crujeiras A, Lopez-Lopez R, Pio R, Montuenga L, Zulueta J, Nadal E, Rosell A, Esteller M, Sandoval J. Abstract LB-155: Identification of a DNA methylation signature in liquid biopsy for early non-small cell lung cancer (NSCLC) diagnosis Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-155  0.391
2016 Moutinho C, Garcia-del-Muro X, Guino E, Vidal A, Puertas S, Muñoz C, Piulats J, Villanueva A, Esteller M. Abstract 432: Loss of MGMT promoter methylation and resistance to cisplatin in non-seminomatous germ cell tumors Cancer Research. 76: 432-432. DOI: 10.1158/1538-7445.Am2016-432  0.437
2016 Llinas P, Lopez P, Esteller M. Abstract 2770: DERL3 hypermethylation alters rhabdomyosarcoma cell metabolism Cancer Research. 76: 2770-2770. DOI: 10.1158/1538-7445.Am2016-2770  0.378
2016 Vizoso M, Puig M, Carmona FJ, Maqueda M, Gomez A, Labernardie A, Gabasa M, Mendizuri S, Ikemori R, Trepat X, Moran S, Vidal E, Reguart N, Perera A, Esteller M, et al. Abstract 2763: DNA methylation profiling unveils TGF-β hyperresponse in tumor associated fibroblasts from lung cancer patients Cancer Research. 76: 2764-2764. DOI: 10.1158/1538-7445.Am2016-2763  0.386
2016 Palomeras S, Diaz-Lagares A, Ariadna S, Belen CA, Ariadna G, Sandoval J, Rabionet M, Esteller M, Puig T. Abstract 2130A: Epigenetic silencing of TGFβ1, BCL6, KILLIN and CTSZ is related to trastuzumab resistance in HER2-positive breast cancer models Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-2130A  0.426
2016 Martín D, Court F, Rello-Varona S, Sáinz-Jaspeado M, Buj R, Morán S, García-Monclús S, Huertas-Martínez J, Mora J, Peinado M, Alonso J, de Álava E, Esteller M, Tirado O. Epigenetic profiling identifies MIR10A-5 p as a putative tumor suppresor in Ewing sarcoma and rhabdomyosarcoma Klinische PäDiatrie. 228. DOI: 10.1055/S-0036-1582504  0.315
2016 Bock C, Halbritter F, Carmona FJ, Tierling S, Datlinger P, Assenov Y, Berdasco M, Bergmann AK, Booher K, Busato F, Campan M, Dahl C, Dahmcke CM, Diep D, Fernández AF, ... ... Esteller M, et al. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications Nature Biotechnology. 34: 726-737. DOI: 10.1038/Nbt.3605  0.38
2016 Villalba M, Diaz-Lagares A, Redrado M, de Aberasturi A, Pajares M, Pio R, Montuenga L, Esteller M, Sandoval J, Calvo A. TMPRSS4 protein overexpression and its promoter hypomethylation predict poor prognosis in squamous lung cancer patients European Journal of Cancer. 61: S14. DOI: 10.1016/S0959-8049(16)61038-9  0.304
2015 da Silva-Diz V, Simón-Extremera P, Bernat-Peguera A, de Sostoa J, Urpí M, Penin RM, Pérez Sidelnikova D, Bermejo O, Viñals JM, Rodolosse A, Gonzalez-Suarez E, Gómez Moruno A, Pujana MA, Esteller M, Villanueva A, et al. Cancer stem cell regulation changes at late stages of skin carcinoma progression to enhance tumor growth and metastasis. Cancer Research. PMID 26719534 DOI: 10.1158/0008-5472.Can-15-1631  0.341
2015 Moran S, Arribas C, Esteller M. Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences. Epigenomics. PMID 26673039 DOI: 10.2217/Epi.15.114  0.427
2015 Nogales V, Reinhold WC, Varma S, Martinez-Cardus A, Moutinho C, Moran S, Heyn H, Sebio A, Barnadas A, Pommier Y, Esteller M. Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs. Oncotarget. PMID 26625211 DOI: 10.18632/Oncotarget.6413  0.451
2015 Adams BD, Anastasiadou E, Esteller M, He L, Slack FJ. The Inescapable Influence of Noncoding RNAs in Cancer. Cancer Research. PMID 26567137 DOI: 10.1158/0008-5472.Can-15-1989  0.32
2015 Roscigno G, Quintavalle C, Donnarumma E, Puoti I, Diaz-Lagares A, Iaboni M, Fiore D, Russo V, Todaro M, Romano G, Thomas R, Cortino G, Gaggianesi M, Esteller M, Croce CM, et al. MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b. Oncotarget. PMID 26556862 DOI: 10.18632/Oncotarget.5979  0.308
2015 Sanchez-Delgado M, Martin-Trujillo A, Tayama C, Vidal E, Esteller M, Iglesias-Platas I, Deo N, Barney O, Maclean K, Hata K, Nakabayashi K, Fisher R, Monk D. Absence of Maternal Methylation in Biparental Hydatidiform Moles from Women with NLRP7 Maternal-Effect Mutations Reveals Widespread Placenta-Specific Imprinting. Plos Genetics. 11: e1005644. PMID 26544189 DOI: 10.1371/Journal.Pgen.1005644  0.402
2015 Vizoso M, Esteller M. Targeting melanoma: unusual epigenetics reveals the dynamic rewiring of metastatic cells. Epigenomics. PMID 26541242 DOI: 10.2217/Epi.15.67  0.309
2015 Gracia A, Balañá C, Kaskens L, Chiavenna S, Matias-Guiu X, Rubio-Rodríguez D, Rubio-Terrés C, Iglesias L, Esteller M. Economic Analysis Of Epicup, An Epigenetic Test To Predict The Tissue Of Origin In Cancer Of Unknown Primary Site, The Usa Payors Perspective. Value in Health : the Journal of the International Society For Pharmacoeconomics and Outcomes Research. 18: A356. PMID 26532014 DOI: 10.1016/J.Jval.2015.09.670  0.311
2015 Vizoso M, Puig M, Carmona FJ, Maqueda M, Velásquez A, Gomez A, Labernadie A, Lugo R, Gabasa M, Rigat-Brugarolas LG, Trepat X, Ramírez J, Reguart N, Moran S, Vidal E, ... ... Esteller M, et al. Aberrant DNA methylation in Non Small Cell Lung Cancer associated fibroblasts. Carcinogenesis. PMID 26449251 DOI: 10.1093/Carcin/Bgv146  0.467
2015 Ferreira HJ, Heyn H, Vizoso M, Moutinho C, Vidal E, Gomez A, Martínez-Cardús A, Simó-Riudalbas L, Moran S, Jost E, Esteller M. DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene. PMID 26434589 DOI: 10.1038/onc.2015.359  0.301
2015 Gallardo F, Sandoval J, Díaz-Lagares A, Garcia R, D'Altri T, González J, Alegre V, Servitje O, Crujeiras AB, Stefánsson ÓA, Espinet B, Hernández MI, Bellosillo B, Esteller M, Pujol RM, et al. Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides. The Journal of Investigative Dermatology. PMID 26302069 DOI: 10.1038/Jid.2015.328  0.372
2015 Vizoso M, Esteller M. DNA methylation plasticity contributes to the natural history of metastasis. Cell Cycle (Georgetown, Tex.). 14: 2863-4. PMID 26223807 DOI: 10.1080/15384101.2015.1076300  0.512
2015 Simó-Riudalbas L, Pérez-Salvia M, Setien F, Villanueva A, Moutinho C, Martínez-Cardús A, Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C, Barceló-Batllori S, ... ... Esteller M, et al. KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer. Cancer Research. 75: 3936-45. PMID 26208904 DOI: 10.1158/0008-5472.Can-14-3702  0.416
2015 Martinez-Balibrea E, Martínez-Cardús A, Ginés A, Ruiz de Porras V, Moutinho C, Layos L, Manzano JL, Bugés C, Bystrup S, Esteller M, Abad A. Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance. Molecular Cancer Therapeutics. 14: 1767-76. PMID 26184483 DOI: 10.1158/1535-7163.Mct-14-0636  0.324
2015 Sáez MA, Fernández-Rodríguez J, Moutinho C, Sanchez-Mut JV, Gomez A, Vidal E, Petazzi P, Szczesna K, Lopez-Serra P, Lucariello M, Lorden P, Delgado-Morales R, de la Caridad OJ, Huertas D, Gelpí JL, ... ... Esteller M, et al. Mutations in JMJD1C are involved in Rett syndrome and intellectual disability. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 26181491 DOI: 10.1038/Gim.2015.100  0.778
2015 Hernando-Herraez I, Heyn H, Fernandez-Callejo M, Vidal E, Fernandez-Bellon H, Prado-Martinez J, Sharp AJ, Esteller M, Marques-Bonet T. The interplay between DNA methylation and sequence divergence in recent human evolution. Nucleic Acids Research. 43: 8204-14. PMID 26170231 DOI: 10.1093/Nar/Gkv693  0.408
2015 Ruiz de Garibay G, Herranz C, Llorente A, Boni J, Serra-Musach J, Mateo F, Aguilar H, Gómez-Baldó L, Petit A, Vidal A, Climent F, Hernández-Losa J, Cordero Á, González-Suárez E, Sánchez-Mut JV, ... Esteller M, et al. Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness. Plos One. 10: e0132546. PMID 26167915 DOI: 10.1371/Journal.Pone.0132546  0.741
2015 Simo-Riudalbas L, Diaz-Lagares A, Gatto S, Gagliardi M, Crujeiras AB, Matarazzo MR, Esteller M, Sandoval J. Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome. Plos One. 10: e0132517. PMID 26161907 DOI: 10.1371/Journal.Pone.0132517  0.453
2015 Liz J, Esteller M. lncRNAs and microRNAs with a role in cancer development. Biochimica Et Biophysica Acta. PMID 26149773 DOI: 10.1016/J.Bbagrm.2015.06.015  0.354
2015 Barault L, Amatu A, Bleeker FE, Moutinho C, Falcomatà C, Fiano V, Cassingena A, Siravegna G, Milione M, Cassoni P, De Braud F, Rudà R, Soffietti R, Venesio T, Bardelli A, ... ... Esteller M, et al. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. PMID 26113646 DOI: 10.1093/Annonc/Mdv272  0.403
2015 Zaina S, Gonçalves I, Carmona FJ, Gomez A, Heyn H, Mollet IG, Moran S, Varol N, Esteller M. DNA Methylation Dynamics in Human Carotid Plaques After Cerebrovascular Events. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26088578 DOI: 10.1161/Atvbaha.115.305630  0.383
2015 Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, Martínez-Cardús A, Girotti MR, Villanueva A, Guil S, Moutinho C, Liz J, Portela A, Heyn H, Moran S, Vidal A, Martinez-Iniesta M, ... ... Esteller M, et al. Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR. Nature Medicine. PMID 26030178 DOI: 10.1038/Nm.3863  0.742
2015 Cappetta M, Berdasco M, Hochmann J, Bonilla C, Sans M, Hidalgo PC, Artagaveytia N, Kittles R, Martínez M, Esteller M, Bertoni B. Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients. Bmc Cancer. 15: 434. PMID 26012346 DOI: 10.1186/S12885-015-1461-0  0.431
2015 Perez-Salvia M, Simó-Riudalbas L, Ausió J, Esteller M. Barcelona conference on epigenetics and cancer: 50 years of histone acetylation. Epigenetics : Official Journal of the Dna Methylation Society. 10: 446-51. PMID 25942103 DOI: 10.1080/15592294.2015.1039222  0.411
2015 Heyn H, Esteller M. An Adenine Code for DNA: A Second Life for N6-Methyladenine. Cell. 161: 710-713. PMID 25936836 DOI: 10.1016/J.Cell.2015.04.021  0.334
2015 Boque-Sastre R, Soler M, Oliveira-Mateos C, Portela A, Moutinho C, Sayols S, Villanueva A, Esteller M, Guil S. Head-to-head antisense transcription and R-loop formation promotes transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America. 112: 5785-90. PMID 25902512 DOI: 10.1073/Pnas.1421197112  0.701
2015 Gurnot C, Martin-Subero I, Mah SM, Weikum W, Goodman SJ, Brain U, Werker JF, Kobor MS, Esteller M, Oberlander TF, Hensch TK. Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics : Official Journal of the Dna Methylation Society. 10: 361-72. PMID 25891251 DOI: 10.1080/15592294.2015.1026031  0.355
2015 Valencia-Morales Mdel P, Zaina S, Heyn H, Carmona FJ, Varol N, Sayols S, Condom E, Ramírez-Ruz J, Gomez A, Moran S, Lund G, Rodríguez-Ríos D, López-González G, Ramírez-Nava M, de la Rocha C, ... ... Esteller M, et al. The DNA methylation drift of the atherosclerotic aorta increases with lesion progression. Bmc Medical Genomics. 8: 7. PMID 25881171 DOI: 10.1186/S12920-015-0085-1  0.422
2015 Martínez de Paz A, Vicente Sanchez-Mut J, Samitier-Martí M, Petazzi P, Sáez M, Szczesna K, Huertas D, Esteller M, Ausió J. Circadian cycle-dependent MeCP2 and brain chromatin changes. Plos One. 10: e0123693. PMID 25875630 DOI: 10.1371/Journal.Pone.0123693  0.347
2015 Agrelo R, Sutz MA, Setien F, Aldunate F, Esteller M, Da Costa V, Achenbach R. A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies. Epigenetics : Official Journal of the Dna Methylation Society. 10: 329-41. PMID 25830902 DOI: 10.1016/S0959-8049(16)30007-7  0.364
2015 Guil S, Esteller M. RNA-RNA interactions in gene regulation: the coding and noncoding players. Trends in Biochemical Sciences. 40: 248-56. PMID 25818326 DOI: 10.1016/J.Tibs.2015.03.001  0.669
2015 Léveillé N, Melo CA, Rooijers K, Díaz-Lagares A, Melo SA, Korkmaz G, Lopes R, Akbari Moqadam F, Maia AR, Wijchers PJ, Geeven G, den Boer ML, Kalluri R, de Laat W, Esteller M, et al. Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA. Nature Communications. 6: 6520. PMID 25813522 DOI: 10.1038/Ncomms7520  0.332
2015 Cascón A, Comino-Méndez I, Currás-Freixes M, de Cubas AA, Contreras L, Richter S, Peitzsch M, Mancikova V, Inglada-Pérez L, Pérez-Barrios A, Calatayud M, Azriel S, Villar-Vicente R, Aller J, Setién F, ... ... Esteller M, et al. Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene. Journal of the National Cancer Institute. 107. PMID 25766404 DOI: 10.1093/Jnci/Djv053  0.317
2015 Barneda-Zahonero B, Collazo O, Azagra A, Fernández-Duran I, Serra-Musach J, Islam AB, Vega-García N, Malatesta R, Camós M, Gómez A, Román-González L, Vidal A, López-Bigas N, Villanueva A, Esteller M, et al. The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma. Cell Death & Disease. 6: e1635. PMID 25675295 DOI: 10.1038/Cddis.2014.594  0.331
2015 Villanueva A, Portela A, Sayols S, Battiston C, Hoshida Y, Méndez-González J, Imbeaud S, Letouzé E, Hernandez-Gea V, Cornella H, Pinyol R, Solé M, Fuster J, Zucman-Rossi J, Mazzaferro V, ... Esteller M, et al. DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma. Hepatology (Baltimore, Md.). 61: 1945-56. PMID 25645722 DOI: 10.1002/Hep.27732  0.365
2015 Stefansson OA, Moran S, Gomez A, Sayols S, Arribas-Jorba C, Sandoval J, Hilmarsdottir H, Olafsdottir E, Tryggvadottir L, Jonasson JG, Eyfjord J, Esteller M. A DNA methylation-based definition of biologically distinct breast cancer subtypes. Molecular Oncology. 9: 555-68. PMID 25468711 DOI: 10.1016/J.Molonc.2014.10.012  0.459
2015 Wrage M, Hagmann W, Kemming D, Uzunoglu FG, Riethdorf S, Effenberger K, Westphal M, Lamszus K, Kim SZ, Becker N, Izbicki JR, Sandoval J, Esteller M, Pantel K, Risch A, et al. Identification of HERC5 and its potential role in NSCLC progression. International Journal of Cancer. Journal International Du Cancer. 136: 2264-72. PMID 25353388 DOI: 10.1002/Ijc.29298  0.38
2015 Fernández AF, Bayón GF, Urdinguio RG, Toraño EG, García MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Bueno C, ... ... Esteller M, et al. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Research. 25: 27-40. PMID 25271306 DOI: 10.1101/Gr.169011.113  0.433
2015 Simó-Riudalbas L, Esteller M. Targeting the histone orthography of cancer: drugs for writers, erasers and readers. British Journal of Pharmacology. 172: 2716-32. PMID 25039449 DOI: 10.1111/Bph.12844  0.431
2015 Amatu A, Bencardino K, Barault L, Cassingena A, Bonazzina E, Ghezzi S, Moutinho C, Tosi F, Ricotta R, Magni E, Gatto R, Marrapese G, Esteller M, Bardelli A, Di Nicolantonio F, et al. Phase II study of temozolomide (TMZ) in metastatic colorectal cancer (mCRC) patients molecularly selected by MGMT promoter hypermethylation. Journal of Clinical Oncology. 33: 583-583. DOI: 10.1200/Jco.2015.33.3_Suppl.583  0.347
2015 Pineda B, Diaz-Lagares A, Perez-Fidalgo JA, Alonso E, Sandoval J, Gonzalez I, Crujeiras A, Burgues O, Esteller M, Lluch A, Eroles P. DNA methylation signature to identify treatment response in triple negative breast cancer. Journal of Clinical Oncology. 33: 1079-1079. DOI: 10.1200/Jco.2015.33.15_Suppl.1079  0.418
2015 Pérez-Salvia M, Simó-Riudalbas L, Esteller M. Abstract 4784: Effect of epigenetic drugs on chromatin remodeling complexes disrupted in cancer Cancer Research. 75: 4784-4784. DOI: 10.1158/1538-7445.Am2015-4784  0.349
2015 Kallio HML, Annala M, Kivinummi K, Högnäs G, Gundem G, Wedge DC, Loo PV, Heyn H, Emmert-Buck MR, Isaacs WB, Esteller M, McDermott U, Nykter M, Visakorpi T, Bova GS. Abstract 3883: Clonal evolution of a lethal prostate cancer: Integrated whole genome analysis case study Cancer Research. 75: 3883-3883. DOI: 10.1158/1538-7445.Am2015-3883  0.359
2014 Stefansson OA, Esteller M. CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer. Breast Cancer Research : Bcr. 16: 307. PMID 25927994 DOI: 10.1186/Bcr3657  0.421
2014 Yuan W, Xia Y, Bell CG, Yet I, Ferreira T, Ward KJ, Gao F, Loomis AK, Hyde CL, Wu H, Lu H, Liu Y, Small KS, Viñuela A, Morris AP, ... ... Esteller M, et al. An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nature Communications. 5: 5719. PMID 25502755 DOI: 10.1038/Ncomms6719  0.398
2014 Huertas-Martínez J, Rello-Varona S, Herrero-Martín D, Barrau I, García-Monclús S, Sáinz-Jaspeado M, Lagares-Tena L, Núñez-Álvarez Y, Mateo-Lozano S, Mora J, Roma J, Toran N, Moran S, López-Alemany R, Gallego S, ... Esteller M, et al. Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth. Oncotarget. 5: 9744-55. PMID 25313138 DOI: 10.18632/Oncotarget.2403  0.386
2014 Ambrogio C, Carmona FJ, Vidal A, Falcone M, Nieto P, Romero OA, Puertas S, Vizoso M, Nadal E, Poggio T, Sánchez-Céspedes M, Esteller M, Mulero F, Voena C, Chiarle R, et al. Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. Cancer Research. 74: 5978-88. PMID 25217522 DOI: 10.1158/0008-5472.Can-14-1606  0.353
2014 Carmona FJ, Davalos V, Vidal E, Gomez A, Heyn H, Hashimoto Y, Vizoso M, Martinez-Cardus A, Sayols S, Ferreira HJ, Sánchez-Mut JV, Morán S, Margelí M, Castella E, Berdasco M, ... ... Esteller M, et al. A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition. Cancer Research. 74: 5608-19. PMID 25106427 DOI: 10.1158/0008-5472.Can-13-3659  0.773
2014 Zaina S, Heyn H, Carmona FJ, Varol N, Sayols S, Condom E, Ramírez-Ruz J, Gomez A, Gonçalves I, Moran S, Esteller M. DNA methylation map of human atherosclerosis. Circulation. Cardiovascular Genetics. 7: 692-700. PMID 25091541 DOI: 10.1161/Circgenetics.113.000441  0.409
2014 Ongen H, Andersen CL, Bramsen JB, Oster B, Rasmussen MH, Ferreira PG, Sandoval J, Vidal E, Whiffin N, Planchon A, Padioleau I, Bielser D, Romano L, Tomlinson I, Houlston RS, ... Esteller M, et al. Putative cis-regulatory drivers in colorectal cancer. Nature. 512: 87-90. PMID 25079323 DOI: 10.1038/Nature13602  0.397
2014 Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, ... ... Esteller M, et al. Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a. Cell Reports. 8: 743-53. PMID 25066127 DOI: 10.1016/J.Celrep.2014.06.048  0.413
2014 Iglesias-Platas I, Martin-Trujillo A, Petazzi P, Guillaumet-Adkins A, Esteller M, Monk D. Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta. Human Molecular Genetics. 23: 6275-85. PMID 24993786 DOI: 10.1093/Hmg/Ddu347  0.375
2014 Szczesna K, de la Caridad O, Petazzi P, Soler M, Roa L, Saez MA, Fourcade S, Pujol A, Artuch-Iriberri R, Molero-Luis M, Vidal A, Huertas D, Esteller M. Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2846-56. PMID 24917201 DOI: 10.1038/Npp.2014.136  0.327
2014 Liz J, Portela A, Soler M, Gómez A, Ling H, Michlewski G, Calin GA, Guil S, Esteller M. Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region. Molecular Cell. 55: 138-47. PMID 24910097 DOI: 10.1016/J.Molcel.2014.05.005  0.678
2014 Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, Bostner J, Karlsson E, Pérez Tenorio G, ... ... Esteller M, et al. VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Research : Bcr. 16: R53. PMID 24886537 DOI: 10.1186/Bcr3664  0.379
2014 Michailidi C, Soudry E, Brait M, Maldonado L, Jaffe A, Ili-Gangas C, Brebi-Mieville P, Perez J, Kim MS, Zhong X, Yang Q, Valle B, Meltzer SJ, Torbenson M, Esteller M, et al. Genome-wide and gene-specific epigenomic platforms for hepatocellular carcinoma biomarker development trials. Gastroenterology Research and Practice. 2014: 597164. PMID 24829571 DOI: 10.1155/2014/597164  0.36
2014 Ausió J, de Paz AM, Esteller M. MeCP2: the long trip from a chromatin protein to neurological disorders. Trends in Molecular Medicine. 20: 487-98. PMID 24766768 DOI: 10.1016/J.Molmed.2014.03.004  0.385
2014 Moran S, Vizoso M, Martinez-Cardús A, Gomez A, Matías-Guiu X, Chiavenna SM, Fernandez AG, Esteller M. Validation of DNA methylation profiling in formalin-fixed paraffin-embedded samples using the Infinium HumanMethylation450 Microarray. Epigenetics : Official Journal of the Dna Methylation Society. 9: 829-33. PMID 24732293 DOI: 10.4161/Epi.28790  0.355
2014 Heyn H, Sayols S, Moutinho C, Vidal E, Sanchez-Mut JV, Stefansson OA, Nadal E, Moran S, Eyfjord JE, Gonzalez-Suarez E, Pujana MA, Esteller M. Linkage of DNA methylation quantitative trait loci to human cancer risk. Cell Reports. 7: 331-8. PMID 24703846 DOI: 10.1016/J.Celrep.2014.03.016  0.775
2014 Lopez-Serra P, Marcilla M, Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S, Vidal A, ... ... Esteller M, et al. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nature Communications. 5: 3608. PMID 24699711 DOI: 10.1038/Ncomms4608  0.388
2014 Court F, Camprubi C, Garcia CV, Guillaumet-Adkins A, Sparago A, Seruggia D, Sandoval J, Esteller M, Martin-Trujillo A, Riccio A, Montoliu L, Monk D. The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus. Epigenetics & Chromatin. 7: 5. PMID 24667089 DOI: 10.1186/1756-8935-7-5  0.419
2014 Petazzi P, Akizu N, García A, Estarás C, Martínez de Paz A, Rodríguez-Paredes M, Martínez-Balbás MA, Huertas D, Esteller M. An increase in MECP2 dosage impairs neural tube formation. Neurobiology of Disease. 67: 49-56. PMID 24657916 DOI: 10.1016/J.Nbd.2014.03.009  0.379
2014 Martínez R, Carmona FJ, Vizoso M, Rohde V, Kirsch M, Schackert G, Ropero S, Paulus W, Barrantes A, Gomez A, Esteller M. DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma. Bmc Cancer. 14: 213. PMID 24650279 DOI: 10.1186/1471-2407-14-213  0.32
2014 Varela-Rey M, Iruarrizaga-Lejarreta M, Lozano JJ, Aransay AM, Fernandez AF, Lavin JL, Mósen-Ansorena D, Berdasco M, Turmaine M, Luka Z, Wagner C, Lu SC, Esteller M, Mirsky R, Jessen KR, et al. S-adenosylmethionine levels regulate the schwann cell DNA methylome. Neuron. 81: 1024-39. PMID 24607226 DOI: 10.1016/J.Neuron.2014.01.037  0.414
2014 Romanelli V, Nakabayashi K, Vizoso M, Moran S, Iglesias-Platas I, Sugahara N, Simón C, Hata K, Esteller M, Court F, Monk D. Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer. Epigenetics : Official Journal of the Dna Methylation Society. 9: 783-90. PMID 24589629 DOI: 10.4161/Epi.28323  0.463
2014 Viré E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, Vidal A, Barbieri I, Aparicio S, Esteller M, Caldas C, Kouzarides T. The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31. Molecular Cell. 53: 806-18. PMID 24582497 DOI: 10.1016/J.Molcel.2014.01.029  0.336
2014 Guo M, Jia Y, Yu Z, House MG, Esteller M, Brock MV, Herman JG. Epigenetic changes associated with neoplasms of the exocrine and endocrine pancreas. Discovery Medicine. 17: 67-73. PMID 24534469  0.316
2014 Sanchez-Mut JV, Aso E, Heyn H, Matsuda T, Bock C, Ferrer I, Esteller M. Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease. Hippocampus. 24: 363-8. PMID 24436131 DOI: 10.1002/Hipo.22245  0.743
2014 Palau A, Perucho M, Esteller M, Buschbeck M. First Barcelona Conference on Epigenetics and Cancer. Epigenetics : Official Journal of the Dna Methylation Society. 9: 468-75. PMID 24413145 DOI: 10.4161/Epi.27759  0.341
2014 Guillaumet-Adkins A, Richter J, Odero MD, Sandoval J, Agirre X, Catala A, Esteller M, Prósper F, Calasanz MJ, Buño I, Kwon M, Court F, Siebert R, Monk D. Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels. Journal of Hematology & Oncology. 7: 4. PMID 24405639 DOI: 10.1186/1756-8722-7-4  0.379
2014 Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K, Sugahara N, Simón C, Moore H, Harness JV, Keirstead H, Sanchez-Mut JV, Kaneki E, Lapunzina P, Soejima H, ... ... Esteller M, et al. Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment. Genome Research. 24: 554-69. PMID 24402520 DOI: 10.1101/Gr.164913.113  0.76
2014 Bonifaci N, Colas E, Serra-Musach J, Karbalai N, Brunet J, Gómez A, Esteller M, Fernández-Taboada E, Berenguer A, Reventós J, Müller-Myhsok B, Amundadottir L, Duell EJ, Pujana MÀ. Integrating gene expression and epidemiological data for the discovery of genetic interactions associated with cancer risk. Carcinogenesis. 35: 578-85. PMID 24296589 DOI: 10.1093/Carcin/Bgt403  0.324
2014 Moutinho C, Martinez-Cardús A, Santos C, Navarro-Pérez V, Martínez-Balibrea E, Musulen E, Carmona FJ, Sartore-Bianchi A, Cassingena A, Siena S, Elez E, Tabernero J, Salazar R, Abad A, Esteller M. Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer. Journal of the National Cancer Institute. 106: djt322. PMID 24273214 DOI: 10.1093/Jnci/Djt322  0.319
2014 Subtil-Rodríguez A, Vázquez-Chávez E, Ceballos-Chávez M, Rodríguez-Paredes M, Martín-Subero JI, Esteller M, Reyes JC. The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes. Nucleic Acids Research. 42: 2185-96. PMID 24265227 DOI: 10.1093/Nar/Gkt1161  0.347
2014 Ferreira HJ, Heyn H, Garcia del Muro X, Vidal A, Larriba S, Muñoz C, Villanueva A, Esteller M. Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis. Epigenetics : Official Journal of the Dna Methylation Society. 9: 113-8. PMID 24247010 DOI: 10.4161/Epi.27237  0.434
2014 Simó-Riudalbas L, Esteller M. Cancer genomics identifies disrupted epigenetic genes. Human Genetics. 133: 713-25. PMID 24104525 DOI: 10.1007/S00439-013-1373-5  0.424
2014 Iliou MS, da Silva-Diz V, Carmona FJ, Ramalho-Carvalho J, Heyn H, Villanueva A, Muñoz P, Esteller M. Impaired DICER1 function promotes stemness and metastasis in colon cancer. Oncogene. 33: 4003-15. PMID 24096488 DOI: 10.1038/Onc.2013.398  0.333
2014 Rodriguez-Paredes M, Martinez de Paz A, Simó-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, Vázquez-Cedeira M, Lazo PA, Carneiro F, Moura CS, Vieira J, Teixeira MR, Esteller M. Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis. Oncogene. 33: 2807-13. PMID 23770855 DOI: 10.1038/Onc.2013.239  0.435
2014 Vaclova T, Woods NT, Setién F, Bueno JMG, Macías JA, Barroso A, Urioste M, Esteller M, Monteiro ANA, Benítez J, Osorio A. Abstract 5483: Implications of the type ofBRCA1germline mutation in the treatment of patients with hereditary breast cancer Cancer Research. 74: 5483-5483. DOI: 10.1158/1538-7445.Am2014-5483  0.353
2014 Martinez-Cardus A, Moutinho C, Santos C, Navarro-Perez V, Martinez-Balibrea E, Musulen E, Carmona FJ, Sartore-Bianchi A, Cassingena A, Siena S, Elez E, Tabernero J, Salazar R, Abad A, Esteller M. Abstract 2829: Identification of the role of SRBC methylation-associated gene silencing as predictive factor of oxaliplatin secondary resistance in metastasic colorectal cancer patients Cancer Research. 74: 2829-2829. DOI: 10.1158/1538-7445.Am2014-2829  0.441
2014 Nogales V, Moutinho C, Martinez-Cardús A, Varma S, Killian JK, Reinhold WC, Meltzer PS, Pommier Y, Esteller M. Abstract 1366: Discovery of biomarkers for antitumor drug resistance using 450K methylation data of NCI60 Cancer Research. 74: 1366-1366. DOI: 10.1158/1538-7445.Am2014-1366  0.448
2014 Barault L, Amatu A, Bleeker F, Moutinho C, Cassingena A, Tosi F, Venesio T, Esteller M, Bardelli A, Siena S, Sartore-Bianchi A, Di Nicolantonio F. 54 MGMT methylation assessed by methyl-BEAMing technique is a prognostic and predictive biomarker in glioblastoma and metastatic colorectal cancer patients European Journal of Cancer. 50: 23. DOI: 10.1016/S0959-8049(14)70180-7  0.332
2013 Quintavalle C, Mangani D, Roscigno G, Romano G, Diaz-Lagares A, Iaboni M, Donnarumma E, Fiore D, De Marinis P, Soini Y, Esteller M, Condorelli G. MiR-221/222 target the DNA methyltransferase MGMT in glioma cells. Plos One. 8: e74466. PMID 24147153 DOI: 10.1371/Journal.Pone.0074466  0.301
2013 Sandoval J, Mendez-Gonzalez J, Nadal E, Chen G, Carmona FJ, Sayols S, Moran S, Heyn H, Vizoso M, Gomez A, Sanchez-Cespedes M, Assenov Y, Müller F, Bock C, Taron M, ... ... Esteller M, et al. A prognostic DNA methylation signature for stage I non-small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 4140-7. PMID 24081945 DOI: 10.1200/Jco.2012.48.5516  0.396
2013 Hernando-Herraez I, Prado-Martinez J, Garg P, Fernandez-Callejo M, Heyn H, Hvilsom C, Navarro A, Esteller M, Sharp AJ, Marques-Bonet T. Dynamics of DNA methylation in recent human and great ape evolution. Plos Genetics. 9: e1003763. PMID 24039605 DOI: 10.1371/Journal.Pgen.1003763  0.443
2013 Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, ... ... Esteller M, et al. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain : a Journal of Neurology. 136: 3018-27. PMID 24030951 DOI: 10.1093/Brain/Awt237  0.77
2013 Heyn H, Moran S, Hernando-Herraez I, Sayols S, Gomez A, Sandoval J, Monk D, Hata K, Marques-Bonet T, Wang L, Esteller M. DNA methylation contributes to natural human variation. Genome Research. 23: 1363-72. PMID 23908385 DOI: 10.1101/Gr.154187.112  0.43
2013 Stefansson OA, Esteller M. Epigenetic modifications in breast cancer and their role in personalized medicine. The American Journal of Pathology. 183: 1052-63. PMID 23899662 DOI: 10.1016/J.Ajpath.2013.04.033  0.431
2013 Vizoso M, Esteller M. German-Catalan workshop on epigenetics and cancer. Epigenetics : Official Journal of the Dna Methylation Society. 8: 998-1003. PMID 23884202 DOI: 10.4161/Epi.25856  0.464
2013 Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, ... ... Esteller M, et al. Global epigenomic reconfiguration during mammalian brain development. Science (New York, N.Y.). 341: 1237905. PMID 23828890 DOI: 10.1126/Science.1237905  0.391
2013 Heyn H, Méndez-González J, Esteller M. Epigenetic profiling joins personalized cancer medicine. Expert Review of Molecular Diagnostics. 13: 473-9. PMID 23782254 DOI: 10.1586/Erm.13.36  0.422
2013 Carmona FJ, Azuara D, Berenguer-Llergo A, Fernández AF, Biondo S, de Oca J, Rodriguez-Moranta F, Salazar R, Villanueva A, Fraga MF, Guardiola J, Capellá G, Esteller M, Moreno V. DNA methylation biomarkers for noninvasive diagnosis of colorectal cancer. Cancer Prevention Research (Philadelphia, Pa.). 6: 656-65. PMID 23694962 DOI: 10.1158/1940-6207.Capr-12-0501  0.434
2013 Muñoz-Pinedo C, González-Suárez E, Portela A, Gentilella A, Esteller M. Exploiting tumor vulnerabilities: epigenetics, cancer metabolism and the mTOR pathway in the era of personalized medicine. Cancer Research. 73: 4185-9. PMID 23687347 DOI: 10.1158/0008-5472.Can-13-0512  0.352
2013 Portela A, Liz J, Nogales V, Setién F, Villanueva A, Esteller M. DNA methylation determines nucleosome occupancy in the 5'-CpG islands of tumor suppressor genes. Oncogene. 32: 5421-8. PMID 23686312 DOI: 10.1038/Onc.2013.162  0.477
2013 Heyn H, Esteller M. EZH2: an epigenetic gatekeeper promoting lymphomagenesis. Cancer Cell. 23: 563-5. PMID 23680141 DOI: 10.1016/J.Ccr.2013.04.028  0.365
2013 Petazzi P, Sandoval J, Szczesna K, Jorge OC, Roa L, Sayols S, Gomez A, Huertas D, Esteller M. Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model. Rna Biology. 10: 1197-203. PMID 23611944 DOI: 10.4161/Rna.24286  0.343
2013 Stuss DP, Cheema M, Ng MK, Martinez de Paz A, Williamson B, Missiaen K, Cosman JD, McPhee D, Esteller M, Hendzel M, Delaney K, Ausió J. Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain. Nucleic Acids Research. 41: 4888-900. PMID 23558747 DOI: 10.1093/Nar/Gkt213  0.384
2013 Guerrero-Setas D, Pérez-Janices N, Blanco-Fernandez L, Ojer A, Cambra K, Berdasco M, Esteller M, Maria-Ruiz S, Torrea N, Guarch R. RASSF2 hypermethylation is present and related to shorter survival in squamous cervical cancer. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 26: 1111-22. PMID 23542458 DOI: 10.1038/Modpathol.2013.32  0.399
2013 Espada J, Esteller M. Mouse models in epigenetics: insights in development and disease. Briefings in Functional Genomics. 12: 279-87. PMID 23426092 DOI: 10.1093/Bfgp/Elt005  0.406
2013 Amatu A, Sartore-Bianchi A, Moutinho C, Belotti A, Bencardino K, Chirico G, Cassingena A, Rusconi F, Esposito A, Nichelatti M, Esteller M, Siena S. Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2265-72. PMID 23422094 DOI: 10.1158/1078-0432.Ccr-12-3518  0.381
2013 Berdasco M, Esteller M. Genetic syndromes caused by mutations in epigenetic genes. Human Genetics. 132: 359-83. PMID 23370504 DOI: 10.1007/S00439-013-1271-X  0.419
2013 Heyn H, Moran S, Esteller M. Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome. Epigenetics : Official Journal of the Dna Methylation Society. 8: 28-33. PMID 23257959 DOI: 10.4161/Epi.23366  0.406
2013 Øster B, Linnet L, Christensen LL, Thorsen K, Ongen H, Dermitzakis ET, Sandoval J, Moran S, Esteller M, Hansen TF, Lamy P, Laurberg S, Ørntoft TF, Andersen CL. Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer. International Journal of Cancer. Journal International Du Cancer. 132: 2303-15. PMID 23115050 DOI: 10.1002/Ijc.27921  0.428
2013 Sandoval J, Heyn H, Méndez-González J, Gomez A, Moran S, Baiget M, Melo M, Badell I, Nomdedéu JF, Esteller M. Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia. British Journal of Haematology. 160: 406-9. PMID 23110451 DOI: 10.1111/Bjh.12113  0.442
2013 Heyn H, Carmona FJ, Gomez A, Ferreira HJ, Bell JT, Sayols S, Ward K, Stefansson OA, Moran S, Sandoval J, Eyfjord JE, Spector TD, Esteller M. DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. Carcinogenesis. 34: 102-8. PMID 23054610 DOI: 10.1093/Carcin/Bgs321  0.421
2013 Azuara D, Rodriguez-Moranta F, De Oca J, Sanjuan X, Guardiola J, Lobaton T, Wang A, Boadas J, Piqueras M, Monfort D, Galter S, Esteller M, Moreno V, Capellá G. Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients Inflammatory Bowel Diseases. 19: 165-173. PMID 22532293 DOI: 10.1002/Ibd.22994  0.323
2013 Moutinho C, Martinez-Cardus A, Santos C, Navarro-Perez V, Martinez-Balibrea E, Abad Esteve A, Salazar R, Esteller M. hSRBC promoter CpG island hypermethylation as resistant predictive biomarker of oxaliplatin based chemotherapy in metastasic colorectal cancer patients. Journal of Clinical Oncology. 31: e14609-e14609. DOI: 10.1200/Jco.2013.31.15_Suppl.E14609  0.416
2013 Amatu A, Sartore Bianchi A, Moutinho C, Bencardino K, Bonazzina E, Pietrogiovanna L, Venturini F, Gambaro A, Marrapese G, Belotti A, Esteller M, Siena S. Phase II study of dacarbazine for metastatic colorectal cancer: Final results with MGMT analysis. Journal of Clinical Oncology. 31: 3581-3581. DOI: 10.1200/Jco.2013.31.15_Suppl.3581  0.391
2013 Martinez JC, Ropero S, Mateos C, Toledo MDV, Samaniego R, Sacristan S, Esteller M. Alteration of the p53 and Rb tumor suppressor pathways by p16/INK4a and p14/ARF promoter methylation and loss of protein expression in recurrent and nonrecurrent meningiomas. Journal of Clinical Oncology. 31: 2064-2064. DOI: 10.1200/Jco.2013.31.15_Suppl.2064  0.416
2013 Brugge Pt, Burg Evd, Kristel P, Boon U, Majewski I, Moutinho C, Esteller M, Hogervorst F, Gevensleben H, Turner N, Kloosterman W, Lips E, Wesseling J. Abstract PR02: Genomic rearrangements and promoter demethylation drive therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-Pr02  0.35
2013 Ramalho-Carvalho J, Henrique R, Sayols S, Gomez A, Jerónimo C, Esteller M. Abstract 4252: Redefining the DNA methylome of prostate cancer using DNA methylation arrays. Cancer Research. 73: 4252-4252. DOI: 10.1158/1538-7445.Am2013-4252  0.424
2013 Huertas-Martinez J, Barrau I, Sáinz-Jaspeado M, Lagares-Tena L, Mateo-Lozano S, Mora J, Roma J, Gallego S, Moran S, Esteller M, Muro XGd, Tirado OM. Abstract 3827: Caveolin-1 acts as a tumor suppressor promoting muscular differentiation in alveolar rhabdomyosarcomas. Cancer Research. 73: 3827-3827. DOI: 10.1158/1538-7445.Am2013-3827  0.339
2013 Stefansson OA, Moran S, Gomez A, Puig SS, Eyfjord J, Esteller M. Abstract 2018: Genome-wide analysis of DNA methylation and copy number changes in breast cancers. Cancer Research. 73: 2018-2018. DOI: 10.1158/1538-7445.Am2013-2018  0.469
2012 Ribel-Madsen R, Fraga MF, Jacobsen S, Bork-Jensen J, Lara E, Calvanese V, Fernandez AF, Friedrichsen M, Vind BF, Højlund K, Beck-Nielsen H, Esteller M, Vaag A, Poulsen P. Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. Plos One. 7: e51302. PMID 23251491 DOI: 10.1371/Journal.Pone.0051302  0.309
2012 Latos PA, Helliwell C, Mosaku O, Dudzinska DA, Stubbs B, Berdasco M, Esteller M, Hendrich B. NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate. Biology Open. 1: 341-52. PMID 23213424 DOI: 10.1242/Bio.2012513  0.45
2012 Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, ... ... Esteller M, et al. Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. Journal of Medicinal Chemistry. 55: 10937-47. PMID 23189967 DOI: 10.1021/Jm3011614  0.306
2012 Mayol G, Martín-Subero JI, Ríos J, Queiros A, Kulis M, Suñol M, Esteller M, Gómez S, Garcia I, de Torres C, Rodríguez E, Galván P, Mora J, Lavarino C. DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis. Plos One. 7: e48401. PMID 23144874 DOI: 10.1371/Journal.Pone.0048401  0.496
2012 Muñoz P, Iliou MS, Esteller M. Epigenetic alterations involved in cancer stem cell reprogramming. Molecular Oncology. 6: 620-36. PMID 23141800 DOI: 10.1016/J.Molonc.2012.10.006  0.412
2012 Esteller M. Cancer, epigenetics and the Nobel Prizes. Molecular Oncology. 6: 565-6. PMID 23141798 DOI: 10.1016/J.Molonc.2012.10.004  0.38
2012 Guil S, Esteller M. Cis-acting noncoding RNAs: friends and foes. Nature Structural & Molecular Biology. 19: 1068-75. PMID 23132386 DOI: 10.1038/Nsmb.2428  0.685
2012 Heyn H, Ferreira HJ, Bassas L, Bonache S, Sayols S, Sandoval J, Esteller M, Larriba S. Epigenetic disruption of the PIWI pathway in human spermatogenic disorders. Plos One. 7: e47892. PMID 23112866 DOI: 10.1371/Journal.Pone.0047892  0.463
2012 Simmer F, Brinkman AB, Assenov Y, Matarese F, Kaan A, Sabatino L, Villanueva A, Huertas D, Esteller M, Lengauer T, Bock C, Colantuoni V, Altucci L, Stunnenberg HG. Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues. Epigenetics : Official Journal of the Dna Methylation Society. 7: 1355-67. PMID 23079744 DOI: 10.4161/Epi.22562  0.471
2012 Krausz C, Sandoval J, Sayols S, Chianese C, Giachini C, Heyn H, Esteller M. Novel insights into DNA methylation features in spermatozoa: stability and peculiarities. Plos One. 7: e44479. PMID 23071498 DOI: 10.1371/Journal.Pone.0044479  0.426
2012 Stefansson OA, Villanueva A, Vidal A, Martí L, Esteller M. BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer Epigenetics. 7: 1225-1229. PMID 23069641 DOI: 10.4161/Epi.22561  0.387
2012 Berdasco M, Melguizo C, Prados J, Gómez A, Alaminos M, Pujana MA, Lopez M, Setien F, Ortiz R, Zafra I, Aranega A, Esteller M. DNA methylation plasticity of human adipose-derived stem cells in lineage commitment American Journal of Pathology. 181: 2079-2093. PMID 23031258 DOI: 10.1016/J.Ajpath.2012.08.016  0.383
2012 Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges Nature Reviews. Genetics. 13: 679-692. PMID 22945394 DOI: 10.1038/Nrg3270  0.453
2012 Stefansson OA, Villanueva A, Vidal A, Martí L, Esteller M. Re: A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy Journal of the National Cancer Institute. 104: 1514. PMID 22923512 DOI: 10.1093/Jnci/Djs363  0.325
2012 Vidal A, Muñoz C, Guillén MJ, Moretó J, Puertas S, Martínez-Iniesta M, Figueras A, Padullés L, García-Rodriguez FJ, Berdiel-Acer M, Pujana MA, Salazar R, Gil-Martin M, Martí L, Ponce J, ... ... Esteller M, et al. Lurbinectedin (PM01183), a new DNA minor groove binder, Inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer Clinical Cancer Research. 18: 5399-5411. PMID 22896654 DOI: 10.1158/1078-0432.Ccr-12-1513  0.302
2012 Vizoso M, Esteller M. The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy Cell Research. 22: 1413-1415. PMID 22710800 DOI: 10.1038/Cr.2012.93  0.311
2012 Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols S, Pujana MA, Serra-Musach J, Iglesias-Platas I, ... ... Esteller M, et al. Distinct DNA methylomes of newborns and centenarians. Proceedings of the National Academy of Sciences of the United States of America. 109: 10522-7. PMID 22689993 DOI: 10.1073/Pnas.1120658109  0.756
2012 Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M. Intronic RNAs mediate EZH2 regulation of epigenetic targets Nature Structural and Molecular Biology. 19: 664-670. PMID 22659877 DOI: 10.1038/Nsmb.2315  0.717
2012 Barrero MJ, Berdasco M, Paramonov I, Bilic J, Vitaloni M, Esteller M, Belmonte JCI. DNA hypermethylation in somatic cells correlates with higher reprogramming efficiency Stem Cells. 30: 1696-1702. PMID 22653871 DOI: 10.1002/Stem.1138  0.408
2012 Ferreira HJ, Heyn H, Moutinho C, Esteller M. CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer Rna Biology. 9: 881-890. PMID 22617881 DOI: 10.4161/Rna.19353  0.467
2012 Heyn H, Vidal E, Sayols S, Sanchez-Mut JV, Moran S, Medina I, Sandoval J, Simó-Riudalbas L, Szczesna K, Huertas D, Gatto S, Matarazzo MR, Dopazo J, Esteller M. Whole-genome bisulfite DNA sequencing of a DNMT3B mutant patient. Epigenetics : Official Journal of the Dna Methylation Society. 7: 542-50. PMID 22595875 DOI: 10.4161/Epi.20523  0.772
2012 Sanchez-Mut JV, Huertas D, Esteller M. Aberrant epigenetic landscape in intellectual disability Progress in Brain Research. 197: 53-71. PMID 22541288 DOI: 10.1016/B978-0-444-54299-1.00004-2  0.73
2012 Stefansson OA, Esteller M. BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: Keeping oncomiRs under control Breast Cancer Research. 14. PMID 22423979 DOI: 10.1186/Bcr3119  0.391
2012 Sandoval J, Esteller M. Cancer epigenomics: beyond genomics. Current Opinion in Genetics & Development. 22: 50-5. PMID 22402447 DOI: 10.1016/J.Gde.2012.02.008  0.422
2012 Carmona FJ, Villanueva A, Vidal A, Muñoz C, Puertas S, Penin RM, Gomà M, Lujambio A, Piulats JM, Mesía R, Sánchez-Céspedes M, Manós M, Condom E, Eccles SA, Esteller M. Epigenetic disruption of cadherin-11 in human cancer metastasis Journal of Pathology. 228: 230-240. PMID 22374749 DOI: 10.1002/Path.4011  0.421
2012 Berdasco M, Esteller M. Hot topics in epigenetic mechanisms of aging: 2011 Aging Cell. 11: 181-186. PMID 22321768 DOI: 10.1111/J.1474-9726.2012.00806.X  0.377
2012 Carmona FJ, Esteller M. DNA methylation in early neoplasia. Cancer Biomarkers : Section a of Disease Markers. 9: 101-11. PMID 22112471 DOI: 10.3233/CBM-2011-0184  0.325
2012 Rubio A, Sánchez-Mut JV, García E, Velasquez ZD, Oliver J, Esteller M, Avila J. Epigenetic control of somatostatin and cortistatin expression by β amyloid peptide Journal of Neuroscience Research. 90: 13-20. PMID 21922516 DOI: 10.1002/Jnr.22731  0.696
2012 Taniguchi H, Jacinto FV, Villanueva A, Fernandez AF, Yamamoto H, Carmona FJ, Puertas S, Marquez VE, Shinomura Y, Imai K, Esteller M. Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer Oncogene. 31: 1988-1994. PMID 21892211 DOI: 10.1038/Onc.2011.387  0.416
2012 Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, Carneiro F, Esteller M. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis Oncogene. 31: 2062-2074. PMID 21874049 DOI: 10.1038/Onc.2011.383  0.338
2012 Lopez-Serra P, Esteller M. DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer Oncogene. 31: 1609-1622. PMID 21860412 DOI: 10.1038/Onc.2011.354  0.346
2012 Fernandez AF, Assenov Y, Martin-Subero JI, Balint B, Siebert R, Taniguchi H, Yamamoto H, Hidalgo M, Tan AC, Galm O, Ferrer I, Sanchez-Cespedes M, Villanueva A, Carmona J, Sanchez-Mut JV, ... ... Esteller M, et al. A DNA methylation fingerprint of 1628 human samples. Genome Research. 22: 407-19. PMID 21613409 DOI: 10.1101/Gr.119867.110  0.773
2012 Javier Carmona F, Esteller M. Dna methylation in early neoplasia Translational Pathology of Early Cancer. 101-111. DOI: 10.3233/Cbm-2011-0184  0.437
2012 Amatu A, Sartore-Bianchi A, Bencardino K, Moutinho C, Marrapese G, Belotti A, Gambaro A, Cassingena A, Venturini F, Giacobbe F, Sporchia A, Lauricella C, Schiavo R, Esteller M, Siena S. Phase II study of dacarbazine for metastatic colorectal cancer with determined MGMT status. Journal of Clinical Oncology. 30: 3570-3570. DOI: 10.1200/Jco.2012.30.15_Suppl.3570  0.346
2012 Moutinho C, Martinez-Cardús A, Martínez-Balibrea E, Abad A, Esteller M. Abstract 835: Epigenetic biomarkers of chemoresistance in colorectal cancer Cancer Research. 72: 835-835. DOI: 10.1158/1538-7445.Am2012-835  0.459
2012 Vizoso M, Carmona J, Moran S, Diaz A, Esteller M. Abstract 4091: Identification of epigenetic alterations associated with tumor progression and cancer metastasis Cancer Research. 72: 4091-4091. DOI: 10.1158/1538-7445.Am2012-4091  0.492
2012 Guillaumet A, Sandoval J, Esteller M, Issa J, Sibert R, Monk D. Abstract 4021: Breaking the dogma: AWT1 hypermethylation in myeloid leukemia despite high expression Cancer Research. 72: 4021-4021. DOI: 10.1158/1538-7445.Am2012-4021  0.478
2012 Stefansson O, Moran S, Eyfjord J, Esteller M. 544 Genomic Analysis of DNA Methylation and Copy Number Changes in Breast Cancer European Journal of Cancer. 48: S129. DOI: 10.1016/S0959-8049(12)71203-0  0.393
2012 Ambrogio C, Carmona F, Santamaria D, Gomez G, Lozano M, Mainardi S, Nieto P, Kocher O, Esteller M, Barbacid M. 25 Proffered Paper: Involvement of Epigenetics in the Early Stages of NSCLC Development European Journal of Cancer. 48: S6. DOI: 10.1016/S0959-8049(12)70729-3  0.369
2012 Davalos V, Esteller M. Rolling the Dice to Discover the Role of DICER in Tumorigenesis Cancer Cell. 21: 717-719. DOI: 10.1016/J.Ccr.2012.05.030  0.325
2011 Rodríguez-Paredes M, Esteller M. A combined epigenetic therapy equals the efficacy of conventional chemotherapy in refractory advanced non-small cell lung cancer Cancer Discovery. 1: 557-559. PMID 22586680 DOI: 10.1158/2159-8290.Cd-11-0271  0.379
2011 Rangel-Salazar R, Wickström-Lindholm M, Aguilar-Salinas CA, Alvarado-Caudillo Y, Døssing KBV, Esteller M, Labourier E, Lund G, Nielsen FC, Rodríguez-Ríos D, Solís-Martínez MO, Wrobel K, Zaina S. Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages Bmc Genomics. 12. PMID 22118513 DOI: 10.1186/1471-2164-12-582  0.42
2011 Incoronato M, Urso L, Portela A, Laukkanen MO, Soini Y, Quintavalle C, Keller S, Esteller M, Condorelli G. Epigenetic Regulation of miR-212 Expression in Lung Cancer Plos One. 6. PMID 22110741 DOI: 10.1371/Journal.Pone.0027722  0.315
2011 Esteller M. Non-coding RNAs in human disease Nature Reviews Genetics. 12: 861-874. PMID 22094949 DOI: 10.1038/Nrg3074  0.304
2011 Iliou MS, Lujambio A, Portela A, Brüstle O, Koch P, Andersson-Vincent PH, Sundström E, Hovatta O, Esteller M. Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer. Epigenetics : Official Journal of the Dna Methylation Society. 6: 1344-53. PMID 22048248 DOI: 10.4161/Epi.6.11.18021  0.437
2011 Berdasco M, Esteller M. DNA methylation in stem cell renewal and multipotency Stem Cell Research and Therapy. 2. PMID 22041459 DOI: 10.1186/Scrt83  0.38
2011 Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, Ule J, Esteller M, Ramos A, Agami R. Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity Nature Communications. 2: 513. PMID 22027593 DOI: 10.1038/Ncomms1519  0.307
2011 Esteller M. Cancer Epigenetics for the 21st Century: What's Next? Genes & Cancer. 2: 604-6. PMID 21941616 DOI: 10.1177/1947601911423096  0.381
2011 Esteller M. Cancer Epigenetics for the 21st Century: What's Next? Genes & Cancer. 2: 604-6. PMID 21941616 DOI: 10.1177/1947601911423096  0.381
2011 Carmona FJ, Esteller M. IDIBELL cancer conference on metastasis and angiogenesis Cancer Research. 71: 6097-6101. PMID 21933886 DOI: 10.1158/0008-5472.Can-11-2180  0.353
2011 Mayor R, Muñoz M, Coolen MW, Custodio J, Esteller M, Clark SJ, Peinado MA. Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. Epigenetics : Official Journal of the Dna Methylation Society. 6: 1138-48. PMID 21852760 DOI: 10.4161/Epi.6.9.16066  0.458
2011 Espada J, Peinado H, Lopez-Serra L, Setién F, Lopez-Serra P, Portela A, Renart J, Carrasco E, Calvo M, Juarranz A, Cano A, Esteller M. Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context. Nucleic Acids Research. 39: 9194-205. PMID 21846773 DOI: 10.1093/Nar/Gkr658  0.309
2011 Wilop S, Fernandez AF, Jost E, Herman JG, Brümmendorf TH, Esteller M, Galm O. Array-based DNA methylation profiling in acute myeloid leukaemia British Journal of Haematology. 155: 65-72. PMID 21790528 DOI: 10.1111/J.1365-2141.2011.08801.X  0.426
2011 Vegliante MC, Royo C, Palomero J, Salaverria I, Balint B, Martín-Guerrero I, Agirre X, Lujambio A, Richter J, Xargay-Torrent S, Bea S, Hernandez L, Enjuanes A, Calasanz MJ, Rosenwald A, ... ... Esteller M, et al. Epigenetic activation of SOX11 in Lymphoid Neoplasms by Histone modifications Plos One. 6. PMID 21738649 DOI: 10.1371/Journal.Pone.0021382  0.433
2011 Javierre BM, Rodriguez-Ubreva J, Al-Shahrour F, Corominas M, Graña O, Ciudad L, Agirre X, Pisano DG, Valencia A, Roman-Gomez J, Calasanz MJ, Prosper F, Esteller M, Gonzalez-Sarmiento R, Ballestar E. Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells. Molecular Cancer Research : McR. 9: 1139-51. PMID 21737484 DOI: 10.1158/1541-7786.Mcr-10-0515  0.424
2011 Stefansson OA, Esteller M. EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells Breast Cancer Research : Bcr. 13: 309. PMID 21672285 DOI: 10.1186/Bcr2871  0.446
2011 Esteller M. Epigenetic changes in cancer. F1000 Biology Reports. 3: 9. PMID 21655338 DOI: 10.3410/B3-9  0.345
2011 Esteller M. Epigenetic changes in cancer. F1000 Biology Reports. 3: 9. PMID 21655338 DOI: 10.3410/B3-9  0.345
2011 Stefansson OA, Jonasson JG, Olafsdottir K, Hilmarsdottir H, Olafsdottir G, Esteller M, Johannsson OT, Eyfjord JE. CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer Epigenetics. 6: 638-649. PMID 21593597 DOI: 10.4161/Epi.6.5.15667  0.382
2011 Sandoval J, Heyn H, Moran S, Serra-Musach J, Pujana MA, Bibikova M, Esteller M. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics : Official Journal of the Dna Methylation Society. 6: 692-702. PMID 21593595 DOI: 10.4161/Epi.6.6.16196  0.463
2011 Guerrero-Preston R, Soudry E, Acero J, Orera M, Moreno-López L, Macía-Colón G, Jaffe A, Berdasco M, Ili-Gangas C, Brebi-Mieville P, Fu Y, Engstrom C, Irizarry RA, Esteller M, Westra W, et al. NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva Cancer Prevention Research. 4: 1061-1072. PMID 21558411 DOI: 10.1158/1940-6207.Capr-11-0006  0.382
2011 Simó-Riudalbas L, Melo SA, Esteller M. DNMT3B gene amplification predicts resistance to DNA demethylating drugs Genes Chromosomes and Cancer. 50: 527-534. PMID 21484930 DOI: 10.1002/Gcc.20877  0.451
2011 Carmona FJ, Esteller M. Moving closer to a prognostic DNA methylation signature in colon cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1215-7. PMID 21411436 DOI: 10.1158/1078-0432.Ccr-10-3446  0.45
2011 Rodríguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology Nature Medicine. 17: 330-339. PMID 21386836 DOI: 10.1038/Nm.2305  0.427
2011 Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J, Vidal A, Aytes A, Puertas S, ... ... Esteller M, et al. Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proceedings of the National Academy of Sciences of the United States of America. 108: 4394-9. PMID 21368194 DOI: 10.1073/Pnas.1014720108  0.314
2011 Melo SA, Esteller M. A precursor microRNA in a cancer cell nucleus: get me out of here! Cell Cycle (Georgetown, Tex.). 10: 922-5. PMID 21346411 DOI: 10.4161/Cc.10.6.15119  0.308
2011 Guerrero D, Guarch R, Ojer A, Casas JM, Méndez-Meca C, Esteller M, Barba-Ramos E, Garcia-Bragado F, Puras A. Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer International Journal of Cancer. 128: 2853-2864. PMID 20734389 DOI: 10.1002/Ijc.25629  0.419
2011 Melo SA, Esteller M. Dysregulation of microRNAs in cancer: Playing with fire Febs Letters. 585: 2087-2099. PMID 20708002 DOI: 10.1016/J.Febslet.2010.08.009  0.351
2011 Esteller M. Epigenetics of breast cancer Breast Cancer Research. 13. DOI: 10.1186/Bcr3004  0.45
2011 Guerrero-Preston R, Soudry E, Jaffe A, Ili-Gangas C, Brebi-Mieville P, Pérez J, Zhong X, Yang Q, Meltzer SJ, Esteller M, Sidransky D. Abstract 3172: Methylation portraits discriminate between hepatocellular carcinoma cases and controls Cancer Research. 71: 3172-3172. DOI: 10.1158/1538-7445.Am2011-3172  0.421
2011 López-Serra P, Martín-Subero I, Esteller M. Abstract 3013: Study of three-dimensional cell culturing influence on DNA methylation profile Cancer Research. 71: 3013-3013. DOI: 10.1158/1538-7445.Am2011-3013  0.391
2011 Ferreira H, Heyn H, Balint B, Martin-Subero JI, Esteller M. Abstract 106: Epigenetic regulation of snoRNAs in cancer Cancer Research. 71: 106-106. DOI: 10.1158/1538-7445.Am2011-106  0.477
2011 ter BP, van dBE, Kristel P, Boon U, Moutinho FC, Esteller M, Hogervorst F, Gevensleben H, Turner N, Wesseling J, Jonkers J. P5-06-02: Response and Acquired Resistance of BRCA1-Deficient Triple-Negative Breast Cancer Xenografts to Alkylators or PARP Inhibitors. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P5-06-02  0.346
2010 Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry. Developmental Cell. 19: 698-711. PMID 21074720 DOI: 10.1016/J.Devcel.2010.10.005  0.49
2010 Portela A, Esteller M. Epigenetic modifications and human disease Nature Biotechnology. 28: 1057-1068. PMID 20944598 DOI: 10.1038/Nbt.1685  0.436
2010 Kulis M, Esteller M. DNA methylation and cancer. Advances in Genetics. 70: 27-56. PMID 20920744 DOI: 10.1016/B978-0-12-380866-0.60002-2  0.486
2010 Faller WJ, Rafferty M, Hegarty S, Gremel G, Ryan D, Fraga MF, Esteller M, Dervan PA, Gallagher WM. Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis. Melanoma Research. 20: 392-400. PMID 20848733 DOI: 10.1097/Cmr.0B013E32833D32A6  0.445
2010 Alvarez S, Suela J, Valencia A, Fernández A, Wunderlich M, Agirre X, Prósper F, Martín-Subero JI, Maiques A, Acquadro F, Rodriguez Perales S, Calasanz MJ, Roman-Gómez J, Siebert R, Mulloy JC, ... ... Esteller M, et al. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. Plos One. 5: e12197. PMID 20808941 DOI: 10.1371/Journal.Pone.0012197  0.376
2010 Lujambio A, Portela A, Liz J, Melo SA, Rossi S, Spizzo R, Croce CM, Calin GA, Esteller M. CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene. 29: 6390-401. PMID 20802525 DOI: 10.1038/Onc.2010.361  0.462
2010 Jerónimo C, Esteller M. DNA methylation markers for prostate cancer with a stem cell twist. Cancer Prevention Research (Philadelphia, Pa.). 3: 1053-5. PMID 20699415 DOI: 10.1158/1940-6207.Capr-10-0131  0.414
2010 Carmona FJ, Esteller M. Epigenomics of human colon cancer. Mutation Research. 693: 53-60. PMID 20691710 DOI: 10.1016/J.Mrfmmm.2010.07.007  0.459
2010 Azuara D, Rodriguez-Moranta F, de Oca J, Soriano-Izquierdo A, Mora J, Guardiola J, Biondo S, Blanco I, Peinado MA, Moreno V, Esteller M, Capellá G. Novel methylation panel for the early detection of colorectal tumors in stool DNA. Clinical Colorectal Cancer. 9: 168-76. PMID 20643622 DOI: 10.3816/Ccc.2010.N.023  0.404
2010 Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, ... ... Esteller M, et al. Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 13736-41. PMID 20631301 DOI: 10.1073/Pnas.1001399107  0.371
2010 Huang TH-, Esteller M. Chromatin Remodeling in Mammary Gland Differentiation and Breast Tumorigenesis Cold Spring Harbor Perspectives in Biology. 2. PMID 20610549 DOI: 10.1101/Cshperspect.A004515  0.456
2010 Lara E, Calvanese V, Huidobro C, Fernández AF, Moncada-Pazos A, Obaya AJ, Aguilera O, González-Sancho JM, Sánchez L, Astudillo A, Muñoz A, López-Otín C, Esteller M, Fraga MF. Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer. Molecular Cancer. 9: 170. PMID 20591152 DOI: 10.1186/1476-4598-9-170  0.339
2010 Mostoslavsky R, Esteller M, Vaquero A. At the crossroad of lifespan, calorie restriction, chromatin and disease: meeting on sirtuins. Cell Cycle (Georgetown, Tex.). 9: 1907-12. PMID 20458180 DOI: 10.4161/Cc.9.10.11481  0.317
2010 Chatagnon A, Ballestar E, Esteller M, Dante R. A role for methyl-CpG binding domain protein 2 in the modulation of the estrogen response of pS2/TFF1 gene. Plos One. 5: e9665. PMID 20300195 DOI: 10.1371/Journal.Pone.0009665  0.409
2010 Veeck J, Esteller M. Breast cancer epigenetics: from DNA methylation to microRNAs. Journal of Mammary Gland Biology and Neoplasia. 15: 5-17. PMID 20101446 DOI: 10.1007/S10911-010-9165-1  0.498
2010 Fernandez AF, Esteller M. Viral epigenomes in human tumorigenesis Oncogene. 29: 1405-1420. PMID 20101211 DOI: 10.1038/Onc.2009.517  0.407
2010 Martinez R, Esteller M. The DNA methylome of glioblastoma multiforme. Neurobiology of Disease. 39: 40-6. PMID 20064612 DOI: 10.1016/J.Nbd.2009.12.030  0.443
2010 Javierre BM, Fernandez AF, Richter J, Al-Shahrour F, Martin-Subero JI, Rodriguez-Ubreva J, Berdasco M, Fraga MF, O'Hanlon TP, Rider LG, Jacinto FV, Lopez-Longo FJ, Dopazo J, Forn M, Peinado MA, ... ... Esteller M, et al. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Research. 20: 170-9. PMID 20028698 DOI: 10.1101/Gr.100289.109  0.433
2010 Davalos V, Esteller M. MicroRNAs and cancer epigenetics: a macrorevolution. Current Opinion in Oncology. 22: 35-45. PMID 19907325 DOI: 10.1097/Cco.0B013E328333Dcbb  0.313
2010 Esteller M. Abstract PL01-03: Epigenetics, aging, and cancer: From DNA methylation to microRNAs Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-Pl01-03  0.502
2010 Riudalbas LS, Melo SA, Mestres AP, Esteller M. Abstract 4887: Genetic analyses of chromatin remodelers in cancer Cancer Research. 70: 4887-4887. DOI: 10.1158/1538-7445.Am10-4887  0.446
2010 Guerrero-Preston RE, Soudry E, Ili-Gangas C, Brebi-Mieville P, Jaffe A, Barr C, Irizarry R, Berdasco M, Fu Y, Orera M, Acero J, Blanco A, Yang Q, Baez A, Esteller M, et al. Abstract 2924: Genome-wide microarray platforms uncover novel hypermethylated genes in an oral squamous cell carcinoma case-control study: A phase I preclinical biomarker development study Cancer Research. 70: 2924-2924. DOI: 10.1158/1538-7445.Am10-2924  0.44
2010 Moutinho C, Blanco I, Martinez R, Esteller M. Abstract 1845: Genetic analyses of MGMT in familial gliomas and colorectal cancer Cancer Research. 70: 1845-1845. DOI: 10.1158/1538-7445.Am10-1845  0.418
2010 Veeck J, Ropero S, Setien F, Gonzalez-Suarez E, Osorio A, Benitez J, Herman J, Tjan-Heijnen V, Esteller M. Abstract S4-8: Promoter CpG Methylation ofBRCA1Predicts Sensitivity to PARP Inhibitors in Breast Cancer Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-S4-8  0.409
2010 Esteller M. 323 Human cancer epigenetics: from DNA methylation to microRNAs European Journal of Cancer Supplements. 8: 85. DOI: 10.1016/S1359-6349(10)71127-7  0.345
2009 Berdasco M, Ropero S, Setien F, Fraga MF, Lapunzina P, Losson R, Alaminos M, Cheung NK, Rahman N, Esteller M. Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proceedings of the National Academy of Sciences of the United States of America. 106: 21830-5. PMID 20018718 DOI: 10.1073/Pnas.0906831106  0.446
2009 Aranda P, Agirre X, Ballestar E, Andreu EJ, Román-Gómez J, Prieto I, Martín-Subero JI, Cigudosa JC, Siebert R, Esteller M, Prosper F. Epigenetic signatures associated with different levels of differentiation potential in human stem cells. Plos One. 4: e7809. PMID 19915669 DOI: 10.1371/Journal.Pone.0007809  0.331
2009 Espada J, Esteller M. DNA methylation and the functional organization of the nuclear compartment. Seminars in Cell & Developmental Biology. 21: 238-46. PMID 19892028 DOI: 10.1016/J.Semcdb.2009.10.006  0.42
2009 Taniguchi H, Fernández AF, Setién F, Ropero S, Ballestar E, Villanueva A, Yamamoto H, Imai K, Shinomura Y, Esteller M. Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Research. 69: 8447-54. PMID 19861541 DOI: 10.1158/0008-5472.Can-09-0551  0.402
2009 Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. The Lancet. Neurology. 8: 1056-72. PMID 19833297 DOI: 10.1016/S1474-4422(09)70262-5  0.768
2009 Jacinto FV, Ballestar E, Esteller M. Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation. Oncogene. 28: 4212-24. PMID 19734945 DOI: 10.1038/Onc.2009.267  0.47
2009 Moncada-Pazos A, Obaya AJ, Fraga MF, Viloria CG, Capellá G, Gausachs M, Esteller M, López-Otín C, Cal S. The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer. Journal of Cell Science. 122: 2906-13. PMID 19638407 DOI: 10.1242/Jcs.050468  0.369
2009 Martinez R, Martin-Subero JI, Rohde V, Kirsch M, Alaminos M, Fernandez AF, Ropero S, Schockert G, Esteller M. A microarray-based DNA methylation study of glioblastoma multiforme Epigenetics. 4: 255-264. PMID 19550145 DOI: 10.4161/Epi.9130  0.464
2009 Wiesmann F, Veeck J, Galm O, Hartmann A, Esteller M, Knüchel R, Dahl E. Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer. Breast Cancer Research : Bcr. 11: R34. PMID 19527488 DOI: 10.1186/Bcr2319  0.369
2009 López de Silanes I, Gorospe M, Taniguchi H, Abdelmohsen K, Srikantan S, Alaminos M, Berdasco M, Urdinguio RG, Fraga MF, Jacinto FV, Esteller M. The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA. Nucleic Acids Research. 37: 2658-71. PMID 19270063 DOI: 10.1093/Nar/Gkp123  0.398
2009 Rodríguez-Paredes M, Ceballos-Chávez M, Esteller M, García-Domínguez M, Reyes JC. The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene. Nucleic Acids Research. 37: 2449-60. PMID 19255092 DOI: 10.1093/Nar/Gkp101  0.394
2009 Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S, ... ... Esteller M, et al. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nature Genetics. 41: 365-70. PMID 19219043 DOI: 10.1038/Ng.317  0.31
2009 Fernandez AF, Rosales C, Lopez-Nieva P, Graña O, Ballestar E, Ropero S, Espada J, Melo SA, Lujambio A, Fraga MF, Pino I, Javierre B, Carmona FJ, Acquadro F, Steenbergen RD, ... ... Esteller M, et al. The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Research. 19: 438-51. PMID 19208682 DOI: 10.1101/Gr.083550.108  0.413
2009 Teixeira FK, Heredia F, Sarazin A, Roudier F, Boccara M, Ciaudo C, Cruaud C, Poulain J, Berdasco M, Fraga MF, Voinnet O, Wincker P, Esteller M, Colot V. A role for RNAi in the selective correction of DNA methylation defects. Science (New York, N.Y.). 323: 1600-4. PMID 19179494 DOI: 10.1126/Science.1165313  0.456
2009 Lujambio A, Esteller M. How epigenetics can explain human metastasis: a new role for microRNAs. Cell Cycle (Georgetown, Tex.). 8: 377-82. PMID 19177007 DOI: 10.4161/Cc.8.3.7526  0.449
2009 Zubia A, Ropero S, Otaegui D, Ballestar E, Fraga MF, Boix-Chornet M, Berdasco M, Martinez A, Coll-Mulet L, Gil J, Cossío FP, Esteller M. Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. Oncogene. 28: 1477-84. PMID 19169274 DOI: 10.1038/Onc.2008.501  0.353
2009 Martín-Subero JI, Kreuz M, Bibikova M, Bentink S, Ammerpohl O, Wickham-Garcia E, Rosolowski M, Richter J, Lopez-Serra L, Ballestar E, Berger H, Agirre X, Bernd HW, Calvanese V, Cogliatti SB, ... ... Esteller M, et al. New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. Blood. 113: 2488-97. PMID 19075189 DOI: 10.1182/Blood-2008-04-152900  0.402
2009 Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, ... ... Esteller M, et al. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 28: 781-91. PMID 19060927 DOI: 10.1038/Onc.2008.436  0.408
2009 Berdasco M, Fraga MF, Esteller M. Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 507: 23-34. PMID 18987803 DOI: 10.1007/978-1-59745-522-0_2  0.374
2009 Guil S, Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. The International Journal of Biochemistry & Cell Biology. 41: 87-95. PMID 18834952 DOI: 10.1016/J.Biocel.2008.09.005  0.758
2009 Azuara D, Rodriguez-Moranta F, Soriano-Izquierdo A, Guardiola J, Oca Jd, Biondo S, Blanco I, Esteller M, Capella G. Evaluation of stool melting curve analysis of methylated CpG island promoters as an alternative for early noninvasive diagnosis of colorectal tumors Journal of Clinical Oncology. 27. DOI: 10.1200/Jco.2009.27.15_Suppl.E15036  0.35
2009 Alvarez S, Suela J, Valencia A, Fernandez A, Wunderlich M, Agirre X, Prosper F, Martin-Subero JI, Maiques A, Acquadro F, Rodriguez-Perales S, Calasanz MJ, Roman-Gomez J, Siebert R, Mulloy JC, ... ... Esteller M, et al. Epigenomic Analysis of Acute Myeloid Leukemia Identifies Specific Patterns and Markes with Clinical and Biological Relevance. Blood. 114: 2394-2394. DOI: 10.1182/Blood.V114.22.2394.2394  0.42
2009 Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, ... ... Esteller M, et al. Erratum: Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect Oncogene. 28: 1168-1168. DOI: 10.1038/Onc.2009.1  0.315
2009 Wilop S, Fernandez A, Jost E, Herman J, Osieka R, Galm O, Esteller M. 9237 Array based CpG island methylation-profiling in acute myelogenous leukemia at diagnosis and relapse European Journal of Cancer Supplements. 7: 571. DOI: 10.1016/S1359-6349(09)71928-7  0.326
2008 Aleman A, Cebrian V, Alvarez M, Lopez V, Orenes E, Lopez-Serra L, Algaba F, Bellmunt J, López-Beltrán A, Gonzalez-Peramato P, Cordon-Cardo C, García J, del Muro JG, Esteller M, Sánchez-Carbayo M. Identification of PMF1 methylation in association with bladder cancer progression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 8236-43. PMID 19088041 DOI: 10.1158/1078-0432.Ccr-08-0778  0.444
2008 Ballestar E, Esteller M. SnapShot: the human DNA methylome in health and disease. Cell. 135: 1144-1144.e1. PMID 19070582 DOI: 10.1016/J.Cell.2008.11.040  0.426
2008 Urdinguio RG, Lopez-Serra L, Lopez-Nieva P, Alaminos M, Diaz-Uriarte R, Fernandez AF, Esteller M. Mecp2-null mice provide new neuronal targets for Rett syndrome. Plos One. 3: e3669. PMID 18989361 DOI: 10.1371/Journal.Pone.0003669  0.411
2008 Segditsas S, Sieber OM, Rowan A, Setien F, Neale K, Phillips RK, Ward R, Esteller M, Tomlinson IP. Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. Experimental and Molecular Pathology. 85: 201-6. PMID 18977219 DOI: 10.1016/J.Yexmp.2008.09.006  0.399
2008 Javierre BM, Esteller M, Ballestar E. Epigenetic connections between autoimmune disorders and haematological malignancies. Trends in Immunology. 29: 616-23. PMID 18951845 DOI: 10.1016/J.It.2008.08.008  0.416
2008 Berdasco M, Alcázar R, García-Ortiz MV, Ballestar E, Fernández AF, Roldán-Arjona T, Tiburcio AF, Altabella T, Buisine N, Quesneville H, Baudry A, Lepiniec L, Alaminos M, Rodríguez R, Lloyd A, ... ... Esteller M, et al. Promoter DNA hypermethylation and gene repression in undifferentiated Arabidopsis cells. Plos One. 3: e3306. PMID 18827894 DOI: 10.1371/Journal.Pone.0003306  0.44
2008 Calvanese V, Horrillo A, Hmadcha A, Suarez-Alvarez B, Fernandez AF, Lara E, Casado S, Menendez P, Bueno C, Garcia-Castro J, Rubio R, Lapunzina P, Alaminos M, Borghese L, Terstegge S, ... ... Esteller M, et al. Cancer genes hypermethylated in human embryonic stem cells. Plos One. 3: e3294. PMID 18820729 DOI: 10.1371/Journal.Pone.0003294  0.455
2008 Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M. A microRNA DNA methylation signature for human cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 13556-61. PMID 18768788 DOI: 10.1073/Pnas.0803055105  0.352
2008 Vera E, Canela A, Fraga MF, Esteller M, Blasco MA. Epigenetic regulation of telomeres in human cancer Oncogene. 27: 6817-6833. PMID 18762811 DOI: 10.1038/Onc.2008.289  0.441
2008 Bertolo C, Guerrero D, Vicente F, Cordoba A, Esteller M, Ropero S, Guillen-Grima F, Martinez-Peñuela JM, Lera JM. Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer. American Journal of Clinical Pathology. 130: 414-24. PMID 18701415 DOI: 10.1309/J3Qv9763Dypv338D  0.337
2008 Mulero-Navarro S, Esteller M. Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer. Epigenetics. 3: 210-5. PMID 18698156 DOI: 10.4161/Epi.3.4.6610  0.482
2008 Lopez-Serra L, Esteller M. Proteins that bind methylated DNA and human cancer: reading the wrong words. British Journal of Cancer. 98: 1881-5. PMID 18542062 DOI: 10.1038/Sj.Bjc.6604374  0.474
2008 José-Enériz ES, Román-Gómez J, Cordeu L, Ballestar E, Gárate L, Andreu EJ, Isidro I, Guruceaga E, Jiménez-Velasco A, Heiniger A, Torres A, Calasanz MJ, Esteller M, Gutiérrez NC, Rubio A, et al. BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia. British Journal of Haematology. 142: 571-82. PMID 18537972 DOI: 10.1111/J.1365-2141.2008.07221.X  0.329
2008 Fraga MF, Berdasco M, Ballestar E, Ropero S, Lopez-Nieva P, Lopez-Serra L, Martín-Subero JI, Calasanz MJ, Lopez de Silanes I, Setien F, Casado S, Fernandez AF, Siebert R, Stifani S, Esteller M. Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies. Cancer Research. 68: 4116-22. PMID 18519670 DOI: 10.1158/0008-5472.Can-08-0085  0.409
2008 Gomez-Duran A, Ballestar E, Carvajal-Gonzalez JM, Marlowe JL, Puga A, Esteller M, Fernandez-Salguero PM. Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner. Journal of Molecular Biology. 380: 1-16. PMID 18508077 DOI: 10.1016/J.Jmb.2008.04.056  0.366
2008 Mulero-Navarro S, Esteller M. Epigenetic biomarkers for human cancer: the time is now. Critical Reviews in Oncology/Hematology. 68: 1-11. PMID 18430583 DOI: 10.1016/J.Critrevonc.2008.03.001  0.481
2008 Moore LE, Pfeiffer RM, Poscablo C, Real FX, Kogevinas M, Silverman D, García-Closas R, Chanock S, Tardón A, Serra C, Carrato A, Dosemeci M, García-Closas M, Esteller M, Fraga M, et al. Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. The Lancet. Oncology. 9: 359-66. PMID 18339581 DOI: 10.1016/S1470-2045(08)70038-X  0.382
2008 Esteller M. Epigenetics in cancer. The New England Journal of Medicine. 358: 1148-59. PMID 18337604 DOI: 10.1056/Nejmra072067  0.416
2008 Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, et al. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology (Baltimore, Md.). 47: 1191-9. PMID 18318442 DOI: 10.1002/Hep.22159  0.324
2008 Ballestar E, Esteller M. Epigenetic gene regulation in cancer. Advances in Genetics. 61: 247-67. PMID 18282509 DOI: 10.1016/S0065-2660(07)00009-0  0.483
2008 Ropero S, Ballestar E, Alaminos M, Arango D, Schwartz S, Esteller M. Transforming pathways unleashed by a HDAC2 mutation in human cancer. Oncogene. 27: 4008-12. PMID 18264134 DOI: 10.1038/Onc.2008.31  0.439
2008 Jacinto FV, Ballestar E, Esteller M. Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome. Biotechniques. 44: 35, 37, 39 passim. PMID 18254377 DOI: 10.2144/000112708  0.431
2008 Jacinto FV, Ballestar E, Ropero S, Esteller M. Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. Cancer Research. 67: 11481-6. PMID 18089774 DOI: 10.1158/0008-5472.Can-07-2687  0.5
2008 Aleman A, Adrien L, Lopez-Serra L, Cordon-Cardo C, Esteller M, Belbin TJ, Sanchez-Carbayo M. Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays. British Journal of Cancer. 98: 466-73. PMID 18087279 DOI: 10.1038/Sj.Bjc.6604143  0.458
2008 Ropero S, Esteller M. Reply to “HDAC2 deficiency and histone acetylation” Nature Genetics. 40: 813-813. DOI: 10.1038/Ng0708-813  0.3
2008 Esteller M. What is Epigenetics Ejc Supplements. 6: 120. DOI: 10.1016/S1359-6349(08)71630-6  0.378
2008 Esteller M. Epigenetics in evolution and disease The Lancet. 372. DOI: 10.1016/S0140-6736(08)61887-5  0.317
2007 Ropero S, Esteller M. The role of histone deacetylases (HDACs) in human cancer. Molecular Oncology. 1: 19-25. PMID 19383284 DOI: 10.1016/J.Molonc.2007.01.001  0.412
2007 Blanco D, Vicent S, Fraga MF, Fernandez-Garcia I, Freire J, Lujambio A, Esteller M, Ortiz-de-Solorzano C, Pio R, Lecanda F, Montuenga LM. Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. Neoplasia (New York, N.Y.). 9: 840-52. PMID 17971904 DOI: 10.1593/Neo.07517  0.337
2007 Honrado E, Osorio A, Milne RL, Paz MF, Melchor L, Cascón A, Urioste M, Cazorla A, Díez O, Lerma E, Esteller M, Palacios J, Benítez J. Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 20: 1298-306. PMID 17885670 DOI: 10.1038/Modpathol.3800969  0.32
2007 Yoshikawa H, Matsubara K, Zhou X, Okamura S, Kubo T, Murase Y, Shikauchi Y, Esteller M, Herman JG, Wei Wang X, Harris CC. WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Molecular Biology of the Cell. 18: 4292-303. PMID 17761539 DOI: 10.1091/Mbc.E06-10-0889  0.348
2007 Caballero R, Setien F, Lopez-Serra L, Boix-Chornet M, Fraga MF, Ropero S, Megias D, Alaminos M, Sanchez-Tapia EM, Montoya MC, Esteller M, Gonzalez-Sarmiento R, Ballestar E. Combinatorial effects of splice variants modulate function of Aiolos. Journal of Cell Science. 120: 2619-30. PMID 17646674 DOI: 10.1242/Jcs.007344  0.323
2007 Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Human Molecular Genetics. R50-9. PMID 17613547 DOI: 10.1093/Hmg/Ddm018  0.505
2007 Lujambio A, Esteller M. CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle (Georgetown, Tex.). 6: 1455-9. PMID 17581274  0.338
2007 Fraga MF, Esteller M. Epigenetics and aging: the targets and the marks. Trends in Genetics : Tig. 23: 413-8. PMID 17559965 DOI: 10.1016/J.Tig.2007.05.008  0.417
2007 Jacinto FV, Esteller M. MGMT hypermethylation: a prognostic foe, a predictive friend. Dna Repair. 6: 1155-60. PMID 17482895 DOI: 10.1016/J.Dnarep.2007.03.013  0.428
2007 Fraga MF, Agrelo R, Esteller M. Cross-talk between aging and cancer: the epigenetic language. Annals of the New York Academy of Sciences. 1100: 60-74. PMID 17460165 DOI: 10.1196/Annals.1395.005  0.418
2007 Aguilera O, Peña C, García JM, Larriba MJ, Ordóñez-Morán P, Navarro D, Barbáchano A, López de Silanes I, Ballestar E, Fraga MF, Esteller M, Gamallo C, Bonilla F, González-Sancho JM, Muñoz A. The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis. 28: 1877-84. PMID 17449905 DOI: 10.1093/Carcin/Bgm094  0.351
2007 López de Silanes I, Quesada MP, Esteller M. Aberrant regulation of messenger RNA 3'-untranslated region in human cancer. Cellular Oncology : the Official Journal of the International Society For Cellular Oncology. 29: 1-17. PMID 17429137 DOI: 10.1155/2007/586139  0.377
2007 Poulsen P, Esteller M, Vaag A, Fraga MF. The epigenetic basis of twin discordance in age-related diseases. Pediatric Research. 61: 38R-42R. PMID 17413848 DOI: 10.1203/Pdr.0B013E31803C7B98  0.359
2007 Jacinto FV, Esteller M. Mutator pathways unleashed by epigenetic silencing in human cancer. Mutagenesis. 22: 247-53. PMID 17412712 DOI: 10.1093/Mutage/Gem009  0.431
2007 Espada J, Ballestar E, Santoro R, Fraga MF, Villar-Garea A, Németh A, Lopez-Serra L, Ropero S, Aranda A, Orozco H, Moreno V, Juarranz A, Stockert JC, Längst G, Grummt I, ... ... Esteller M, et al. Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells Nucleic Acids Research. 35: 2191-2198. PMID 17355984 DOI: 10.1093/Nar/Gkm118  0.452
2007 Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps Nature Reviews Genetics. 8: 286-298. PMID 17339880 DOI: 10.1038/Nrg2005  0.475
2007 Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setién F, Casado S, Suarez-Gauthier A, Sanchez-Cespedes M, Git A, Gitt A, Spiteri I, Das PP, Caldas C, Miska E, ... Esteller M, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Research. 67: 1424-9. PMID 17308079 DOI: 10.1158/0008-5472.Can-06-4218  0.382
2007 Martinez R, Setien F, Voelter C, Casado S, Quesada MP, Schackert G, Esteller M. CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis. 28: 1264-8. PMID 17272309 DOI: 10.1093/Carcin/Bgm014  0.459
2007 Espada J, Esteller M. Epigenetic control of nuclear architecture. Cellular and Molecular Life Sciences : Cmls. 64: 449-57. PMID 17221334 DOI: 10.1007/S00018-007-6358-X  0.398
2007 Herranz M, Esteller M. DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets. Methods in Molecular Biology (Clifton, N.J.). 361: 25-62. PMID 17172706 DOI: 10.1385/1-59745-208-4:25  0.489
2007 Martinez R, Schackert G, Yaya-Tur R, Rojas-Marcos I, Herman JG, Esteller M. Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme Journal of Neuro-Oncology. 83: 91-93. PMID 17164975 DOI: 10.1007/S11060-006-9292-0  0.384
2007 Matarazzo MR, De Bonis ML, Strazzullo M, Cerase A, Ferraro M, Vastarelli P, Ballestar E, Esteller M, Kudo S, D'Esposito M. Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events. Journal of Cellular Physiology. 210: 711-9. PMID 17133344 DOI: 10.1002/Jcp.20879  0.41
2007 Martinez R, Schackert G, Esteller M. Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. Journal of Neuro-Oncology. 82: 133-139. PMID 17048097 DOI: 10.1007/S11060-006-9264-4  0.413
2007 Perrin D, Ballestar E, Fraga MF, Frappart L, Esteller M, Guerin JF, Dante R. Specific hypermethylation of LINE-1 elements during abnormal overgrowth and differentiation of human placenta. Oncogene. 26: 2518-24. PMID 17043645 DOI: 10.1038/sj.onc.1210039  0.329
2007 Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA. Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1). The Journal of Pathology. 210: 441-9. PMID 17029216 DOI: 10.1002/Path.2064  0.438
2007 Lopez-Serra L, Ballestar E, Fraga MF, Alaminos M, Setien F, Esteller M. A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer. Cancer Research. 66: 8342-6. PMID 16951140 DOI: 10.1158/0008-5472.Can-06-1932  0.46
2007 Aleman A, Adrien L, Lopez L, Cordon-Cardo C, Esteller M, Belbin T, Sanchez-Carbayo M. 486 DISCOVERY OF DNA HYPERMETHYLATION OF BDNF, SOX9 AND PMF1 ASSOCIATED WITH BLADDER CANCER PROGRESSION USING CPG ISLAND ARRAYS European Urology Supplements. 6: 144. DOI: 10.1016/S1569-9056(07)60484-9  0.406
2007 Christoph F, Ropero S, Lopez P, Hinz S, Krause H, Miller K, Esteller M. 1585: Methylation of Topoisomerase-1 Gene Reduces Risk for Tumor Recurrence after Early Instillation Therapy in Superfical Urothelial Carcinoma Journal of Urology. 177: 524-524. DOI: 10.1016/S0022-5347(18)31773-7  0.329
2007 Lujambio A, Esteller M. CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle. 6: 1455-1459. DOI: 10.1007/0-387-27443-X_6  0.465
2006 Tang M, Torres-Lanzas J, Lopez-Rios F, Esteller M, Sanchez-Cespedes M. Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung. International Journal of Cancer. 119: 2603-6. PMID 16991125 DOI: 10.1002/Ijc.22211  0.367
2006 Rodriguez J, Frigola J, Vendrell E, Risques RA, Fraga MF, Morales C, Moreno V, Esteller M, Capellà G, Ribas M, Peinado MA. Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Research. 66: 8462-9468. PMID 16951157 DOI: 10.1158/0008-5472.Can-06-0293  0.402
2006 Marcé S, Balagué O, Colomo L, Martinez A, Höller S, Villamor N, Bosch F, Ott G, Rosenwald A, Leoni L, Esteller M, Fraga MF, Montserrat E, Colomer D, Campo E. Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 3754-61. PMID 16778103 DOI: 10.1158/1078-0432.Ccr-05-2780  0.321
2006 Ballestar E, Esteller M, Richardson BC. The epigenetic face of systemic lupus erythematosus. Journal of Immunology (Baltimore, Md. : 1950). 176: 7143-7. PMID 16751355 DOI: 10.4049/Jimmunol.176.12.7143  0.416
2006 Agrelo R, Cheng WH, Setien F, Ropero S, Espada J, Fraga MF, Herranz M, Paz MF, Sanchez-Cespedes M, Artiga MJ, Guerrero D, Castells A, von Kobbe C, Bohr VA, Esteller M. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proceedings of the National Academy of Sciences of the United States of America. 103: 8822-7. PMID 16723399 DOI: 10.1073/Pnas.0600645103  0.455
2006 Esteller M. The necessity of a human epigenome project. Carcinogenesis. 27: 1121-5. PMID 16699174 DOI: 10.1093/Carcin/Bgl033  0.471
2006 Herranz M, Esteller M. New therapeutic targets in cancer: the epigenetic connection. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 8: 242-9. PMID 16648099 DOI: 10.1007/Bf02664934  0.485
2006 Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, ... ... Esteller M, et al. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition Nature Genetics. 38: 566-569. PMID 16642021 DOI: 10.1038/Ng1773  0.399
2006 Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, Blasco MA. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nature Cell Biology. 8: 416-24. PMID 16565708 DOI: 10.1038/Ncb1386  0.405
2006 Hernández-Vargas H, Ballestar E, Carmona-Saez P, von Kobbe C, Bañón-Rodríguez I, Esteller M, Moreno-Bueno G, Palacios J. Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. International Journal of Cancer. 119: 1164-75. PMID 16557594 DOI: 10.1002/Ijc.21938  0.36
2006 Castells A, Payá A, Alenda C, Rodríguez-Moranta F, Agrelo R, Andreu M, Piñol V, Castellví-Bel S, Jover R, Llor X, Pons E, Elizalde JI, Bessa X, Alcedo J, Saló J, ... ... Esteller M, et al. Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency Clinical Cancer Research. 12: 1686-1692. PMID 16551850 DOI: 10.1158/1078-0432.Ccr-05-1581  0.37
2006 Boix-Chornet M, Fraga MF, Villar-Garea A, Caballero R, Espada J, Nuñez A, Casado J, Largo C, Casal JI, Cigudosa JC, Franco L, Esteller M, Ballestar E. Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis. The Journal of Biological Chemistry. 281: 13540-7. PMID 16531610 DOI: 10.1074/Jbc.M601136200  0.373
2006 Hellebrekers DM, Jair KW, Viré E, Eguchi S, Hoebers NT, Fraga MF, Esteller M, Fuks F, Baylin SB, van Engeland M, Griffioen AW. Angiostatic activity of DNA methyltransferase inhibitors. Molecular Cancer Therapeutics. 5: 467-75. PMID 16505122 DOI: 10.1158/1535-7163.Mct-05-0417  0.371
2006 Cebrian A, Pharoah PD, Ahmed S, Ropero S, Fraga MF, Smith PL, Conroy D, Luben R, Perkins B, Easton DF, Dunning AM, Esteller M, Ponder BA. Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis. 27: 1661-9. PMID 16501248 DOI: 10.1093/Carcin/Bgi375  0.404
2006 Aguilera O, Fraga MF, Ballestar E, Paz MF, Herranz M, Espada J, García JM, Muñoz A, Esteller M, González-Sancho JM. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene. 25: 4116-21. PMID 16491118 DOI: 10.1038/Sj.Onc.1209439  0.425
2006 Mulero-Navarro S, Carvajal-Gonzalez JM, Herranz M, Ballestar E, Fraga MF, Ropero S, Esteller M, Fernandez-Salguero PM. The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding. Carcinogenesis. 27: 1099-104. PMID 16410262 DOI: 10.1093/Carcin/Bgi344  0.413
2006 Esteller M. Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. British Journal of Cancer. 94: 179-83. PMID 16404435 DOI: 10.1038/Sj.Bjc.6602918  0.483
2006 Yzaguirre MMd, Hernández JS, Navarro PF, Nieva PL, Herranz M, Fraga MF, Esteller M, Juarranz A, Fernández-Piqueras J. Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas. Carcinogenesis. 27: 1081-1089. PMID 16377805 DOI: 10.1093/Carcin/Bgi331  0.352
2006 Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F. The Polycomb group protein EZH2 directly controls DNA methylation. Nature. 439: 871-4. PMID 16357870 DOI: 10.1038/Nature04431  0.447
2006 Rafferty M, Faller L, Fraga M, Esteller M, Gallagher W. DNA methylation in melanoma progression Melanoma Research. 16: S15-S16. DOI: 10.1097/00008390-200609001-00026  0.407
2006 Aleman A, Adrien L, Lopez L, Cordon-Cardo C, Esteller M, Belbin T, Sanchez-Carbayo M. 136 POSTER Discovery of DNAa hypermethylation targets associated with baldder cancer progression using CpG island microarrays European Journal of Cancer Supplements. 4: 44. DOI: 10.1016/S1359-6349(06)70142-2  0.379
2006 Esteller M. Cancer epigenetics: From DNA methylation to histone modifications Toxicology Letters. 164: S17-S18. DOI: 10.1016/j.toxlet.2006.06.040  0.332
2005 Herranz M, Martín-Caballero J, Fraga MF, Ruiz-Cabello J, Flores JM, Desco M, Marquez V, Esteller M. The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma. Blood. 107: 1174-7. PMID 16239434 DOI: 10.1182/Blood-2005-05-2033  0.374
2005 Fraga MF, Esteller M. Towards the human cancer epigenome: a first draft of histone modifications. Cell Cycle (Georgetown, Tex.). 4: 1377-81. PMID 16205112 DOI: 10.4161/Cc.4.10.2113  0.475
2005 Rubio-Moscardo F, Blesa D, Mestre C, Siebert R, Balasas T, Benito A, Rosenwald A, Climent J, Martinez JI, Schilhabel M, Karran EL, Gesk S, Esteller M, deLeeuw R, Staudt LM, et al. Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood. 106: 3214-22. PMID 16051735 DOI: 10.1182/Blood-2005-05-2013  0.316
2005 Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, ... ... Esteller M, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences of the United States of America. 102: 10604-9. PMID 16009939 DOI: 10.1073/Pnas.0500398102  0.419
2005 Esteller M, Almouzni G. How epigenetics integrates nuclear functions Embo Reports. 6: 624-628. PMID 15976819 DOI: 10.1038/Sj.Embor.7400456  0.308
2005 Ballestar E, Esteller M. Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 83: 374-84. PMID 15959563 DOI: 10.1139/O05-035  0.461
2005 Gallagher WM, Bergin OE, Rafferty M, Kelly ZD, Nolan IM, Fox EJ, Culhane AC, McArdle L, Fraga MF, Hughes L, Currid CA, O'Mahony F, Byrne A, Murphy AA, Moss C, ... ... Esteller M, et al. Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies. Carcinogenesis. 26: 1856-67. PMID 15958521 DOI: 10.1093/Carcin/Bgi152  0.404
2005 Ballestar E, Esteller M. The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications. Progress in Molecular and Subcellular Biology. 38: 169-81. PMID 15881895 DOI: 10.1007/3-540-27310-7_7  0.482
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