Paul J. Fletcher - Publications

Affiliations: 
2012- Centre for Addiction and Mental Health 

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Browne CJ, Abela AR, Chu D, Li Z, Ji X, Lambe EK, Fletcher PJ. Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30420603 DOI: 10.1038/s41386-018-0271-x  0.96
2018 Abela AR, Li Z, Lê AD, Fletcher PJ. Clozapine reduces nicotine self-administration, blunts reinstatement of nicotine-seeking but increases responding for food. Addiction Biology. PMID 29575323 DOI: 10.1111/adb.12619  0.36
2018 Fletcher PJ, Li Z, Silenieks LB, MacMillan C, DeLannoy I, Higgins GA. Preclinical evidence for combining the 5-HTreceptor agonist lorcaserin and varenicline as a treatment for nicotine dependence. Addiction Biology. PMID 29498158 DOI: 10.1111/adb.12602  0.72
2017 Higgins GA, Zeeb FD, Fletcher PJ. Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists. Journal of Psychopharmacology (Oxford, England). 269881117735797. PMID 29072522 DOI: 10.1177/0269881117735797  0.96
2017 Zeeb FD, Li Z, Fisher DC, Zack MH, Fletcher PJ. Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder. Journal of Psychiatry & Neuroscience : Jpn. 42: 170003. PMID 28832319 DOI: 10.1503/jpn.170003  0.96
2017 Browne CJ, Ji X, Higgins GA, Fletcher PJ, Harvey-Lewis C. Pharmacological Modulation of 5-HT2C Receptor Activity Produces Bidirectional Changes in Locomotor Activity, Responding for a Conditioned Reinforcer, and Mesolimbic DA Release in C57BL/6 Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28720903 DOI: 10.1038/npp.2017.124  0.96
2017 Higgins GA, Silenieks LB, Patrick A, De Lannoy IA, Fletcher PJ, Parker LA, MacLusky NJ, Sullivan LC, Chavera TA, Berg KA. Studies To Examine Potential Tolerability Differences between the 5-HT2C Receptor Selective Agonists Lorcaserin and CP-809101. Acs Chemical Neuroscience. PMID 28338324 DOI: 10.1021/acschemneuro.6b00444  0.72
2017 Fletcher PJ, Li Z, Coen KM, Lê AD. Acquisition of nicotine self-administration in amphetamine and phencyclidine models of schizophrenia: A role for stress? Schizophrenia Research. PMID 28318841 DOI: 10.1016/j.schres.2017.02.028  0.36
2017 Fletcher PJ, Zeeb FD, Browne CJ, Higgins GA, Soko AD. Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate. Psychopharmacology. PMID 28097374 DOI: 10.1007/s00213-017-4529-5  0.96
2016 Higgins GA, Silenieks LB, Altherr EB, MacMillan C, Fletcher PJ, Pratt WE. Lorcaserin and CP-809101 reduce motor impulsivity and reinstatement of food seeking behavior in male rats: Implications for understanding the anti-obesity property of 5-HT2C receptor agonists. Psychopharmacology. PMID 27241709 DOI: 10.1007/s00213-016-4329-3  0.72
2016 Browne CJ, Fletcher PJ. Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27125304 DOI: 10.1038/npp.2016.63  0.92
2016 Zeeb FD, Soko AD, Ji X, Fletcher PJ. Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26781518 DOI: 10.1038/npp.2016.9  0.32
2015 Browne CJ, Fletcher PJ, Zeeb FD. Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors. Psychopharmacology. PMID 26690588 DOI: 10.1007/s00213-015-4178-5  0.96
2015 Harvey-Lewis C, Li Z, Higgins GA, Fletcher PJ. The 5-HT2C receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity. Neuropharmacology. PMID 26427596 DOI: 10.1016/j.neuropharm.2015.09.028  0.96
2015 Higgins GA, Fletcher PJ. Therapeutic Potential of 5-HT2C Receptor Agonists for Addictive Disorders. Acs Chemical Neuroscience. 6: 1071-88. PMID 25870913 DOI: 10.1021/acschemneuro.5b00025  0.96
2015 Zeeb FD, Higgins GA, Fletcher PJ. The Serotonin 2C Receptor Agonist Lorcaserin Attenuates Intracranial Self-Stimulation and Blocks the Reward-Enhancing Effects of Nicotine. Acs Chemical Neuroscience. 6: 1231-40. PMID 25781911 DOI: 10.1021/acschemneuro.5b00017  0.96
2015 Higgins GA, Desnoyer J, Van Niekerk A, Silenieks LB, Lau W, Thevarkunnel S, Izhakova J, DeLannoy IA, Fletcher PJ, DeLay J, Dobson H. Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity. Pharmacology Research & Perspectives. 3: e00084. PMID 25692009 DOI: 10.1002/prp2.84  0.72
2015 Lister J, Fletcher PJ, Nobrega JN, Remington G. Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia? Pharmacology, Biochemistry, and Behavior. 134: 70-78. PMID 25661529 DOI: 10.1016/j.pbb.2015.01.020  0.96
2015 Fervaha G, Takeuchi H, Lee J, Foussias G, Fletcher PJ, Agid O, Remington G. Antipsychotics and amotivation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1539-48. PMID 25567425 DOI: 10.1038/npp.2015.3  0.96
2015 McCormick PN, Fletcher PJ, Wilson VS, Browne JD, Nobrega JN, Remington GJ. Low dose pramipexole causes D3 receptor-independent reduction of locomotion and responding for a conditioned reinforcer. Neuropharmacology. 89: 225-31. PMID 25283483 DOI: 10.1016/j.neuropharm.2014.09.026  0.96
2014 Su P, Li S, Chen S, Lipina TV, Wang M, Lai TK, Lee FH, Zhang H, Zhai D, Ferguson SS, Nobrega JN, Wong AH, Roder JC, Fletcher PJ, Liu F. A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects. Neuron. 84: 1302-16. PMID 25433637 DOI: 10.1016/j.neuron.2014.11.007  0.96
2014 Guy EG, Fisher DC, Higgins GA, Fletcher PJ. Examination of the effects of varenicline, bupropion, lorcaserin, or naltrexone on responding for conditioned reinforcement in nicotine-exposed rats. Behavioural Pharmacology. 25: 775-83. PMID 25230208 DOI: 10.1097/FBP.0000000000000092  0.96
2014 Guy EG, Fletcher PJ. Responding for a conditioned reinforcer, and its enhancement by nicotine, is blocked by dopamine receptor antagonists and a 5-HT(2C) receptor agonist but not by a 5-HT(2A) receptor antagonist. Pharmacology, Biochemistry, and Behavior. 125: 40-7. PMID 25158104 DOI: 10.1016/j.pbb.2014.08.006  0.96
2014 Browne JD, Soko AD, Fletcher PJ. Responding for conditioned reinforcement in C57BL/6 and CD-1 mice, and Sprague-Dawley rats: Effects of methylphenidate and amphetamine. Psychopharmacology. 231: 4503-16. PMID 24804572 DOI: 10.1007/s00213-014-3602-6  0.96
2014 Lister J, Nobrega JN, Fletcher PJ, Remington G. Oxidative stress and the antipsychotic-induced vacuous chewing movement model of tardive dyskinesia: evidence for antioxidant-based prevention strategies. Psychopharmacology. 231: 2237-49. PMID 24752659 DOI: 10.1007/s00213-014-3582-6  0.96
2014 Zack M, Featherstone RE, Mathewson S, Fletcher PJ. Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats. Frontiers in Behavioral Neuroscience. 8: 36. PMID 24574987 DOI: 10.3389/fnbeh.2014.00036  0.96
2014 Guy EG, Fletcher PJ. The effects of nicotine exposure during Pavlovian conditioning in rats on several measures of incentive motivation for a conditioned stimulus paired with water. Psychopharmacology. 231: 2261-71. PMID 24317443 DOI: 10.1007/s00213-013-3375-3  0.96
2014 Hahn MK, Chintoh A, Remington G, Teo C, Mann S, Arenovich T, Fletcher P, Lam L, Nobrega J, Guenette M, Cohn T, Giacca A. Effects of intracerebroventricular (ICV) olanzapine on insulin sensitivity and secretion in vivo: an animal model. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 448-58. PMID 24001874 DOI: 10.1016/j.euroneuro.2013.07.011  0.96
2013 Hahn MK, Wolever TM, Arenovich T, Teo C, Giacca A, Powell V, Clarke L, Fletcher P, Cohn T, McIntyre RS, Gomes S, Chintoh A, Remington GJ. Acute effects of single-dose olanzapine on metabolic, endocrine, and inflammatory markers in healthy controls. Journal of Clinical Psychopharmacology. 33: 740-6. PMID 24100786 DOI: 10.1097/JCP.0b013e31829e8333  0.96
2013 Higgins GA, Sellers EM, Fletcher PJ. From obesity to substance abuse: therapeutic opportunities for 5-HT2C receptor agonists. Trends in Pharmacological Sciences. 34: 560-70. PMID 24041919 DOI: 10.1016/j.tips.2013.08.001  0.96
2013 Aleksandrova LR, Creed MC, Fletcher PJ, Lobo DS, Hamani C, Nobrega JN. Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task. Behavioural Brain Research. 245: 76-82. PMID 23434606 DOI: 10.1016/j.bbr.2013.02.011  0.96
2013 Wheeler AL, Lerch JP, Chakravarty MM, Friedel M, Sled JG, Fletcher PJ, Josselyn SA, Frankland PW. Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1797-803a. PMID 23365219 DOI: 10.1523/JNEUROSCI.3830-12.2013  0.96
2013 Mann S, Chintoh A, Giacca A, Fletcher P, Nobrega J, Hahn M, Remington G. Chronic olanzapine administration in rats: effect of route of administration on weight, food intake and body composition. Pharmacology, Biochemistry, and Behavior. 103: 717-22. PMID 23234835 DOI: 10.1016/j.pbb.2012.12.002  0.96
2013 Burton CL, Rizos Z, Diwan M, Nobrega JN, Fletcher PJ. Antagonizing 5-HTâ‚‚A receptors with M100907 and stimulating 5-HTâ‚‚C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats. Behavioural Brain Research. 240: 171-81. PMID 23201361 DOI: 10.1016/j.bbr.2012.11.030  0.96
2013 Fletcher PJ, Soko AD, Higgins GA. Impulsive action in the 5-choice serial reaction time test in 5-HTâ‚‚c receptor null mutant mice. Psychopharmacology. 226: 561-70. PMID 23192316 DOI: 10.1007/s00213-012-2929-0  0.96
2013 Higgins GA, Silenieks LB, Lau W, de Lannoy IA, Lee DK, Izhakova J, Coen K, Le AD, Fletcher PJ. Evaluation of chemically diverse 5-HTâ‚‚c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology. 226: 475-90. PMID 23184281 DOI: 10.1007/s00213-012-2919-2  0.96
2013 Lipina TV, Fletcher PJ, Lee FH, Wong AH, Roder JC. Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 423-36. PMID 23011268 DOI: 10.1038/npp.2012.197  0.96
2013 Guy EG, Fletcher PJ. Nicotine-induced enhancement of responding for conditioned reinforcement in rats: role of prior nicotine exposure and α4β2 nicotinic receptors. Psychopharmacology. 225: 429-40. PMID 22885874 DOI: 10.1007/s00213-012-2832-8  0.96
2012 Tuerke KJ, Limebeer CL, Fletcher PJ, Parker LA. Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13709-17. PMID 23035083 DOI: 10.1523/JNEUROSCI.2042-12.2012  0.96
2012 Creed MC, Hamani C, Bridgman A, Fletcher PJ, Nobrega JN. Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9574-81. PMID 22787043 DOI: 10.1523/JNEUROSCI.1196-12.2012  0.96
2012 Fletcher PJ, Rizos Z, Noble K, Soko AD, Silenieks LB, Lê AD, Higgins GA. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Neuropharmacology. 62: 2288-98. PMID 22342986 DOI: 10.1016/j.neuropharm.2012.01.023  0.96
2012 Burton CL, Fletcher PJ. Age and sex differences in impulsive action in rats: the role of dopamine and glutamate. Behavioural Brain Research. 230: 21-33. PMID 22326372 DOI: 10.1016/j.bbr.2012.01.046  0.96
2012 Higgins GA, Silenieks LB, Rossmann A, Rizos Z, Noble K, Soko AD, Fletcher PJ. The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1177-91. PMID 22189292 DOI: 10.1038/npp.2011.303  0.96
2012 Rock EM, Bolognini D, Limebeer CL, Cascio MG, Anavi-Goffer S, Fletcher PJ, Mechoulam R, Pertwee RG, Parker LA. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. British Journal of Pharmacology. 165: 2620-34. PMID 21827451 DOI: 10.1111/j.1476-5381.2011.01621.x  0.96
2011 Hahn M, Chintoh A, Giacca A, Xu L, Lam L, Mann S, Fletcher P, Guenette M, Cohn T, Wolever T, Arenovich T, Remington G. Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: an animal model. Schizophrenia Research. 131: 90-5. PMID 21696923 DOI: 10.1016/j.schres.2011.06.004  0.96
2011 Lovic V, Keen D, Fletcher PJ, Fleming AS. Early-life maternal separation and social isolation produce an increase in impulsive action but not impulsive choice. Behavioral Neuroscience. 125: 481-91. PMID 21688886 DOI: 10.1037/a0024367  0.96
2011 Burton CL, Noble K, Fletcher PJ. Enhanced incentive motivation for sucrose-paired cues in adolescent rats: possible roles for dopamine and opioid systems. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1631-43. PMID 21508935 DOI: 10.1038/npp.2011.44  0.96
2011 Fletcher PJ, Rizos Z, Noble K, Higgins GA. Impulsive action induced by amphetamine, cocaine and MK801 is reduced by 5-HT(2C) receptor stimulation and 5-HT(2A) receptor blockade. Neuropharmacology. 61: 468-77. PMID 21402085 DOI: 10.1016/j.neuropharm.2011.02.025  0.96
2011 Hamani C, Diwan M, Raymond R, Nobrega JN, MacEdo CE, Brandão ML, Shumake J, Gonzalez-Lima F, Lozano AM, Fletcher PJ. Reply to: Electrical brain stimulation in depression: Which target(s)? Biological Psychiatry. 69: e7-e8. DOI: 10.1016/j.biopsych.2010.10.012  0.96
2010 Pei L, Li S, Wang M, Diwan M, Anisman H, Fletcher PJ, Nobrega JN, Liu F. Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects. Nature Medicine. 16: 1393-5. PMID 21113156 DOI: 10.1038/nm.2263  0.96
2010 Perreault ML, Hasbi A, Alijaniaram M, Fan T, Varghese G, Fletcher PJ, Seeman P, O'Dowd BF, George SR. The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. The Journal of Biological Chemistry. 285: 36625-34. PMID 20864528 DOI: 10.1074/jbc.M110.159954  0.96
2010 Wang M, Pei L, Fletcher PJ, Kapur S, Seeman P, Liu F. Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization. Molecular Brain. 3: 25. PMID 20813060 DOI: 10.1186/1756-6606-3-25  0.96
2010 Fletcher PJ, Sinyard J, Higgins GA. Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement. Pharmacology, Biochemistry, and Behavior. 97: 170-8. PMID 20624416 DOI: 10.1016/j.pbb.2010.07.002  0.96
2010 Lipina TV, Niwa M, Jaaro-Peled H, Fletcher PJ, Seeman P, Sawa A, Roder JC. Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia. Genes, Brain, and Behavior. 9: 777-89. PMID 20618446 DOI: 10.1111/j.1601-183X.2010.00615.x  0.96
2010 Bailey CD, De Biasi M, Fletcher PJ, Lambe EK. The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9241-52. PMID 20610759 DOI: 10.1523/JNEUROSCI.2258-10.2010  0.96
2010 Burton CL, Nobrega JN, Fletcher PJ. The effects of adolescent methylphenidate self-administration on responding for a conditioned reward, amphetamine-induced locomotor activity, and neuronal activation. Psychopharmacology. 208: 455-68. PMID 20020108 DOI: 10.1007/s00213-009-1745-7  0.96
2010 Hamani C, Diwan M, Macedo CE, Brandão ML, Shumake J, Gonzalez-Lima F, Raymond R, Lozano AM, Fletcher PJ, Nobrega JN. Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats. Biological Psychiatry. 67: 117-24. PMID 19819426 DOI: 10.1016/j.biopsych.2009.08.025  0.96
2009 Kaidanovich-Beilin O, Lipina TV, Takao K, van Eede M, Hattori S, Laliberté C, Khan M, Okamoto K, Chambers JW, Fletcher PJ, MacAulay K, Doble BW, Henkelman M, Miyakawa T, Roder J, et al. Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Molecular Brain. 2: 35. PMID 19925672 DOI: 10.1186/1756-6606-2-35  0.96
2009 Fletcher PJ, Tampakeras M, Sinyard J, Slassi A, Isaac M, Higgins GA. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology. 57: 259-67. PMID 19501602 DOI: 10.1016/j.neuropharm.2009.05.011  0.96
2009 Featherstone RE, Burton CL, Coppa-Hopman R, Rizos Z, Sinyard J, Kapur S, Fletcher PJ. Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine. Pharmacology, Biochemistry, and Behavior. 93: 382-90. PMID 19467255 DOI: 10.1016/j.pbb.2009.05.010  0.96
2009 Fletcher PJ, Chambers JW, Rizos Z, Chintoh AF. Effects of 5-HT depletion in the frontal cortex or nucleus accumbens on response inhibition measured in the 5-choice serial reaction time test and on a DRL schedule. Behavioural Brain Research. 201: 88-98. PMID 19428621 DOI: 10.1016/j.bbr.2009.01.036  0.96
2009 Dzung Lê A, Funk D, Harding S, Juzytsch W, Fletcher PJ. The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats. Psychopharmacology. 204: 477-88. PMID 19229522 DOI: 10.1007/s00213-009-1481-z  0.96
2009 Chintoh AF, Mann SW, Lam L, Giacca A, Fletcher P, Nobrega J, Remington G. Insulin resistance and secretion in vivo: effects of different antipsychotics in an animal model. Schizophrenia Research. 108: 127-33. PMID 19157785 DOI: 10.1016/j.schres.2008.12.012  0.96
2008 Chintoh AF, Mann SW, Lam L, Lam C, Cohn TA, Fletcher PJ, Nobrega JN, Giacca A, Remington G. Insulin resistance and decreased glucose-stimulated insulin secretion after acute olanzapine administration. Journal of Clinical Psychopharmacology. 28: 494-9. PMID 18794643 DOI: 10.1097/JCP.0b013e318184b4c5  0.96
2008 Fletcher PJ, Lê AD, Higgins GA. Serotonin receptors as potential targets for modulation of nicotine use and dependence. Progress in Brain Research. 172: 361-83. PMID 18772042 DOI: 10.1016/S0079-6123(08)00918-7  0.96
2008 Botly LC, Burton CL, Rizos Z, Fletcher PJ. Characterization of methylphenidate self-administration and reinstatement in the rat. Psychopharmacology. 199: 55-66. PMID 18483809 DOI: 10.1007/s00213-008-1093-z  0.96
2008 Featherstone RE, Rizos Z, Kapur S, Fletcher PJ. A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory. Behavioural Brain Research. 189: 170-9. PMID 18299157 DOI: 10.1016/j.bbr.2007.12.032  0.96
2008 Lê AD, Lê Dzung A, Funk D, Harding S, Juzytsch W, Li Z, Fletcher PJ. Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward. Psychopharmacology. 195: 605-15. PMID 17891381 DOI: 10.1007/s00213-007-0943-4  0.96
2008 Young EJ, Lipina T, Tam E, Mandel A, Clapcote SJ, Bechard AR, Chambers J, Mount HT, Fletcher PJ, Roder JC, Osborne LR. Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice. Genes, Brain, and Behavior. 7: 224-34. PMID 17680805 DOI: 10.1111/j.1601-183X.2007.00343.x  0.96
2008 Fletcher PJ, Rizos Z, Sinyard J, Tampakeras M, Higgins GA. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1402-12. PMID 17653111 DOI: 10.1038/sj.npp.1301509  0.96
2007 Featherstone RE, Kapur S, Fletcher PJ. The amphetamine-induced sensitized state as a model of schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31: 1556-71. PMID 17884274 DOI: 10.1016/j.pnpbp.2007.08.025  0.96
2007 Fletcher PJ, Tampakeras M, Sinyard J, Higgins GA. Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. Psychopharmacology. 195: 223-34. PMID 17673981 DOI: 10.1007/s00213-007-0891-z  0.96
2007 Lee FJ, Pei L, Moszczynska A, Vukusic B, Fletcher PJ, Liu F. Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. The Embo Journal. 26: 2127-36. PMID 17380124 DOI: 10.1038/sj.emboj.7601656  0.96
2007 Fletcher PJ, Tenn CC, Sinyard J, Rizos Z, Kapur S. A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1122-32. PMID 17047670 DOI: 10.1038/sj.npp.1301221  0.96
2007 Featherstone RE, Rizos Z, Nobrega JN, Kapur S, Fletcher PJ. Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 483-92. PMID 17035930 DOI: 10.1038/sj.npp.1301223  0.96
2007 Li M, Fletcher PJ, Kapur S. Time course of the antipsychotic effect and the underlying behavioral mechanisms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 263-72. PMID 16738541 DOI: 10.1038/sj.npp.1301110  0.96
2006 Lovic V, Fleming AS, Fletcher PJ. Early life tactile stimulation changes adult rat responsiveness to amphetamine. Pharmacology, Biochemistry, and Behavior. 84: 497-503. PMID 16860377 DOI: 10.1016/j.pbb.2006.06.013  0.96
2006 Fletcher PJ, Sinyard J, Higgins GA. The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists. Psychopharmacology. 187: 515-25. PMID 16832658 DOI: 10.1007/s00213-006-0453-9  0.96
2006 Placenza FM, Fletcher PJ, Vaccarino FJ, Erb S. Effects of central neurokinin-1 receptor antagonism on cocaine- and opiate-induced locomotor activity and self-administration behaviour in rats. Pharmacology, Biochemistry, and Behavior. 84: 94-101. PMID 16757018 DOI: 10.1016/j.pbb.2006.04.011  0.96
2006 Lê AD, Funk D, Harding S, Juzytsch W, Fletcher PJ, Shaham Y. Effects of dexfenfluramine and 5-HT3 receptor antagonists on stress-induced reinstatement of alcohol seeking in rats. Psychopharmacology. 186: 82-92. PMID 16521030 DOI: 10.1007/s00213-006-0346-y  0.96
2006 Natesan S, Reckless GE, Nobrega JN, Fletcher PJ, Kapur S. Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1854-63. PMID 16319908 DOI: 10.1038/sj.npp.1300983  0.96
2005 Fletcher PJ, Tenn CC, Rizos Z, Lovic V, Kapur S. Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Psychopharmacology. 183: 190-200. PMID 16220338 DOI: 10.1007/s00213-005-0157-6  0.96
2005 Placenza FM, Vaccarino FJ, Fletcher PJ, Erb S. Activation of central neurokinin-1 receptors induces reinstatement of cocaine-seeking behavior. Neuroscience Letters. 390: 42-7. PMID 16125318 DOI: 10.1016/j.neulet.2005.07.050  0.96
2005 Tenn CC, Kapur S, Fletcher PJ. Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition. Psychopharmacology. 180: 366-76. PMID 15856186 DOI: 10.1007/s00213-005-2253-z  0.96
2005 Tenn CC, Fletcher PJ, Kapur S. A putative animal model of the "prodromal" state of schizophrenia. Biological Psychiatry. 57: 586-93. PMID 15780845 DOI: 10.1016/j.biopsych.2004.12.013  0.96
2005 Funk D, Li Z, Fletcher PJ, Lê AD. Effects of injections of 8-hydroxy-2-(di-n-propylamino)tetralin or muscimol in the median raphe nucleus on c-fos mRNA in the rat brain. Neuroscience. 131: 475-9. PMID 15708488 DOI: 10.1016/j.neuroscience.2004.11.026  0.96
2004 Limebeer CL, Parker LA, Fletcher PJ. 5,7-dihydroxytryptamine lesions of the dorsal and median raphe nuclei interfere with lithium-induced conditioned gaping, but not conditioned taste avoidance, in rats. Behavioral Neuroscience. 118: 1391-9. PMID 15598147 DOI: 10.1037/0735-7044.118.6.1391  0.96
2004 Li M, Parkes J, Fletcher PJ, Kapur S. Evaluation of the motor initiation hypothesis of APD-induced conditioned avoidance decreases. Pharmacology, Biochemistry, and Behavior. 78: 811-9. PMID 15301940 DOI: 10.1016/j.pbb.2004.05.023  0.96
2004 Placenza FM, Fletcher PJ, Rotzinger S, Vaccarino FJ. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology. 177: 111-20. PMID 15167979 DOI: 10.1007/s00213-004-1912-9  0.96
2004 Fletcher PJ, Sinyard J, Salsali M, Baker GB. Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects. Psychopharmacology. 174: 406-13. PMID 14740149 DOI: 10.1007/s00213-003-1747-9  0.96
2004 Fletcher PJ, Chintoh AF, Sinyard J, Higgins GA. Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 308-18. PMID 14666118 DOI: 10.1038/sj.npp.1300319  0.96
2003 Higgins GA, Fletcher PJ. Serotonin and drug reward: focus on 5-HT2C receptors. European Journal of Pharmacology. 480: 151-62. PMID 14623358 DOI: 10.1016/j.ejphar.2003.08.102  0.96
2003 Tenn CC, Fletcher PJ, Kapur S. Amphetamine-sensitized animals show a sensorimotor gating and neurochemical abnormality similar to that of schizophrenia. Schizophrenia Research. 64: 103-14. PMID 14613675 DOI: 10.1016/S0920-9964(03)00009-4  0.96
2003 Higgins GA, Enderlin M, Haman M, Fletcher PJ. The 5-HT2A receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism. Psychopharmacology. 170: 309-19. PMID 12904968 DOI: 10.1007/s00213-003-1549-0  0.96
2003 Schwartz RA, Greenwald ER, Fletcher PJ, Houle S, DaSilva JN. Up-regulated dopamine D1 receptor binding can be detected in vivo following repeated SCH 23390, but not SKF 81297 or 6-hydroxydopamine, treatments. European Journal of Pharmacology. 459: 195-201. PMID 12524146 DOI: 10.1016/S0014-2999(02)02850-9  0.96
2002 Hebb MO, Lang AE, Fletcher PJ, Chambers JW, Lozano AM. Neonatal ablation of the nigrostriatal dopamine pathway does not influence limb development in rats. Experimental Neurology. 177: 547-56. PMID 12429200 DOI: 10.1006/exnr.2002.8005  0.96
2002 Fletcher PJ, Grottick AJ, Higgins GA. Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 576-86. PMID 12377394 DOI: 10.1016/S0893-133X(02)00342-1  0.96
2002 Lê AD, Harding S, Juzytsch W, Fletcher PJ, Shaham Y. The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7844-9. PMID 12223536  0.96
2002 Ross BM, Brooks RJ, Lee M, Kalasinsky KS, Vorce SP, Seeman M, Fletcher PJ, Turenne SD. Cyclooxygenase inhibitor modulation of dopamine-related behaviours. European Journal of Pharmacology. 450: 141-51. PMID 12206852 DOI: 10.1016/S0014-2999(02)02104-0  0.96
2002 Fletcher PJ, Korth KM, Robinson SR, Baker GB. Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement. Psychopharmacology. 162: 282-91. PMID 12122486 DOI: 10.1007/s00213-002-1104-4  0.96
2002 Fletcher PJ, Azampanah A, Korth KM. Activation of 5-HT(1B) receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule. Pharmacology, Biochemistry, and Behavior. 71: 717-25. PMID 11888563 DOI: 10.1016/S0091-3057(01)00717-1  0.96
2002 Higgins GA, Fletcher PJ. Serotonin-based therapeutics. Pharmacology, Biochemistry, and Behavior. 71: 531-2. PMID 11888545  0.96
2001 Sills TL, Azampanah A, Fletcher PJ. The adenosine A2A agonist CGS 21680 reverses the reduction in prepulse inhibition of the acoustic startle response induced by phencyclidine, but not by apomorphine and amphetamine. Psychopharmacology. 156: 187-93. PMID 11549222 DOI: 10.1007/s002130100777  0.96
2001 Fletcher PJ, Robinson SR, Slippoy DL. Pre-exposure to (+/-)3,4-methylenedioxy-methamphetamine (MDMA) facilitates acquisition of intravenous cocaine self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: 195-203. PMID 11425503 DOI: 10.1016/S0893-133X(01)00222-6  0.96
2001 Fletcher PJ, Selhi ZF, Azampanah A, Sills TL. Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex. Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 399-409. PMID 11182535 DOI: 10.1016/S0893-133X(00)00215-3  0.96
2001 Choi YH, Fletcher PJ, Anderson GH. Extracellular amino acid profiles in the paraventricular nucleus of the rat hypothalamus are influenced by diet composition. Brain Research. 892: 320-8. PMID 11172779 DOI: 10.1016/S0006-8993(00)03267-4  0.96
2000 Grottick AJ, Fletcher PJ, Higgins GA. Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. The Journal of Pharmacology and Experimental Therapeutics. 295: 1183-91. PMID 11082456  0.96
2000 Brown CM, Coscina DV, Fletcher PJ. The rewarding properties of neuropeptide Y in perifornical hypothalamus vs. nucleus accumbens. Peptides. 21: 1279-87. PMID 11035216 DOI: 10.1016/S0196-9781(00)00270-9  0.96
2000 Karasinska JM, George SR, El-Ghundi M, Fletcher PJ, O'Dowd BF. Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors. European Journal of Pharmacology. 399: 171-81. PMID 10884517 DOI: 10.1016/S0014-2999(00)00347-2  0.96
2000 Sills TL, Greenshaw AJ, Baker GB, Fletcher PJ. Subchronic fluoxetine treatment induces a transient potentiation of amphetamine-induced hyperlocomotion: possible pharmacokinetic interaction. Behavioural Pharmacology. 11: 109-16. PMID 10877115  0.96
2000 Wadenberg MG, Sills TL, Fletcher PJ, Kapur S. Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats. Biological Psychiatry. 47: 670-6. PMID 10745061 DOI: 10.1016/S0006-3223(99)00267-X  0.96
2000 Choi YH, Chang N, Fletcher PJ, Anderson GH. Dietary protein content affects the profiles of extracellular amino acids in the medial preoptic area of freely moving rats. Life Sciences. 66: 1105-18. PMID 10737361 DOI: 10.1016/S0024-3205(00)00414-8  0.96
1999 Fletcher PJ, Korth KM. RU-24969 disrupts d-amphetamine self-administration and responding for conditioned reward via stimulation of 5-HT1B receptors. Behavioural Pharmacology. 10: 183-93. PMID 10780831  0.96
1999 Fletcher PJ, Korth KM, Chambers JW. Selective destruction of brain serotonin neurons by 5,7-dihydroxytryptamine increases responding for a conditioned reward. Psychopharmacology. 147: 291-9. PMID 10639688 DOI: 10.1007/s002130051170  0.96
1999 El-Ghundi M, Fletcher PJ, Drago J, Sibley DR, O'Dowd BF, George SR. Spatial learning deficit in dopamine D(1) receptor knockout mice. European Journal of Pharmacology. 383: 95-106. PMID 10585522 DOI: 10.1016/S0014-2999(99)00573-7  0.96
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