| Year |
Citation |
Score |
| 2023 |
Baral B, Matroodi S, Siitonen V, Thapa K, Akhgari A, Yamada K, Nuutila A, Metsä-Ketelä M. Co-factor independent oxidases ncnN and actVA-3 are involved in the dimerization of benzoisochromanequinone antibiotics in naphthocyclinone and actinorhodin biosynthesis. Fems Microbiology Letters. 370. PMID 37989784 DOI: 10.1093/femsle/fnad123 |
0.445 |
|
| 2022 |
Wang R, Nguyen J, Hecht J, Schwartz N, Brown KV, Ponomareva LV, Niemczura M, van Dissel D, van Wezel GP, Thorson JS, Metsä-Ketelä M, Shaaban KA, Nybo SE. A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in . Acs Synthetic Biology. PMID 36378506 DOI: 10.1021/acssynbio.2c00498 |
0.357 |
|
| 2020 |
Matroodi S, Siitonen V, Baral B, Yamada K, Akhgari A, Metsä-Ketelä M. Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic sp. PA3. Frontiers in Microbiology. 11: 1237. PMID 32582127 DOI: 10.3389/fmicb.2020.01237 |
0.321 |
|
| 2019 |
Fewer DP, Metsä-Ketelä M. A pharmaceutical model for the molecular evolution of microbial natural products. The Febs Journal. PMID 31693795 DOI: 10.1111/febs.15129 |
0.323 |
|
| 2019 |
Grocholski T, Yamada K, Sinkkonen J, Tirkkonen H, Niemi J, Metsä-Ketelä M. Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases. Acs Chemical Biology. PMID 30995392 DOI: 10.1021/acschembio.9b00238 |
0.367 |
|
| 2018 |
Baral B, Akhgari A, Metsä-Ketelä M. Activation of microbial secondary metabolic pathways: Avenues and challenges. Synthetic and Systems Biotechnology. 3: 163-178. PMID 30345402 DOI: 10.1016/j.synbio.2018.09.001 |
0.442 |
|
| 2017 |
Palmu K, Rosenqvist P, Thapa K, Ilina Y, Siitonen V, Baral B, Mäkinen J, Belogurov G, Virta P, Niemi J, Metsä-Ketelä M. Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics. Acs Chemical Biology. PMID 28418235 DOI: 10.1021/acschembio.7b00078 |
0.466 |
|
| 2015 |
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890 |
0.369 |
|
| 2015 |
Guo F, Xiang S, Li L, Wang B, Rajasärkkä J, Gröndahl-Yli-Hannuksela K, Ai G, Metsä-Ketelä M, Yang K. Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection. Metabolic Engineering. 28: 134-42. PMID 25554073 DOI: 10.1016/J.Ymben.2014.12.006 |
0.504 |
|
| 2013 |
Ueberschaar N, Xu Z, Scherlach K, Metsä-Ketelä M, Bretschneider T, Dahse HM, Görls H, Hertweck C. Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities. Journal of the American Chemical Society. 135: 17408-16. PMID 24143864 DOI: 10.1021/Ja4080024 |
0.405 |
|
| 2013 |
Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsä-Ketelä M, Arai T, Okamoto S, Ichinose K. Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics. Chemistry & Biology. 20: 510-20. PMID 23601640 DOI: 10.1016/j.chembiol.2013.03.007 |
0.347 |
|
| 2012 |
Siitonen V, Claesson M, Patrikainen P, Aromaa M, Mäntsälä P, Schneider G, Metsä-Ketelä M. Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin. Chembiochem : a European Journal of Chemical Biology. 13: 120-8. PMID 22120896 DOI: 10.1002/cbic.201100637 |
0.379 |
|
| 2009 |
Xu Z, Metsä-Ketelä M, Hertweck C. Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives. Journal of Biotechnology. 140: 107-13. PMID 19047004 DOI: 10.1016/J.Jbiotec.2008.10.013 |
0.495 |
|
| 2008 |
Oja T, Palmu K, Lehmussola H, Leppäranta O, Hännikäinen K, Niemi J, Mäntsälä P, Metsä-Ketelä M. Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis. Chemistry & Biology. 15: 1046-57. PMID 18940666 DOI: 10.1016/j.chembiol.2008.07.022 |
0.53 |
|
| 2007 |
Palmu K, Ishida K, Mäntsälä P, Hertweck C, Metsä-Ketelä M. Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem : a European Journal of Chemical Biology. 8: 1577-84. PMID 17654627 DOI: 10.1002/Cbic.200700140 |
0.618 |
|
| 2004 |
Metsä-Ketelä M, Ylihonko K, Mäntsälä P. Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64. The Journal of Antibiotics. 57: 502-10. PMID 15515887 |
0.597 |
|
| 2003 |
Metsä-Ketelä M, Palmu K, Kunnari T, Ylihonko K, Mäntsälä P. Engineering anthracycline biosynthesis toward angucyclines. Antimicrobial Agents and Chemotherapy. 47: 1291-6. PMID 12654660 DOI: 10.1128/AAC.47.4.1291-1296.2003 |
0.509 |
|
| 2002 |
Metsä-Ketelä M, Halo L, Munukka E, Hakala J, Mäntsälä P, Ylihonko K. Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species. Applied and Environmental Microbiology. 68: 4472-9. PMID 12200302 DOI: 10.1128/AEM.68.9.4472-4479.2002 |
0.381 |
|
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