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Hans Renata - Publications

Affiliations: 
2008-2013 Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stout CN, Wasfy NM, Chen F, Renata H. Charting the Evolution of Chemoenzymatic Strategies in the Syntheses of Complex Natural Products. Journal of the American Chemical Society. 145: 18161-18181. PMID 37553092 DOI: 10.1021/jacs.3c03422  0.374
2023 Amatuni A, Shuster A, Abegg D, Adibekian A, Renata H. Comprehensive Structure-Activity Relationship Studies of Cepafungin Enabled by Biocatalytic C-H Oxidations. Acs Central Science. 9: 239-251. PMID 36844499 DOI: 10.1021/acscentsci.2c01219  0.314
2022 Li J, Chen F, Renata H. Concise Chemoenzymatic Synthesis of Gedunin. Journal of the American Chemical Society. PMID 36222746 DOI: 10.1021/jacs.2c09048  0.358
2022 Li F, Deng H, Renata H. Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids. Journal of the American Chemical Society. 144: 7616-7621. PMID 35452234 DOI: 10.1021/jacs.2c02958  0.788
2021 Li F, Renata H. A Chiral-Pool-Based Strategy to Access -Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, -Acetyl-polyveoline and the Chrodrimanins. Journal of the American Chemical Society. PMID 34670085 DOI: 10.1021/jacs.1c08696  0.775
2021 Renata H. Exploration of Iron- and a-Ketoglutarate-Dependent Dioxygenases as Practical Biocatalysts in Natural Product Synthesis. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 32: 775-784. PMID 34413574 DOI: 10.1055/s-0040-1707320  0.319
2021 Renata H, Shimizu E, Zwick CR. Regiodivergent Biocatalytic Hydroxylation of L-Glutamine Facilitated by Characterization of Non-Heme Dioxygenases from Non-Ribosomal Peptide Biosyntheses. Tetrahedron. 90. PMID 34366493 DOI: 10.1016/j.tet.2021.132190  0.366
2021 Li F, Yang LC, Zhang J, Chen J, Renata H. Stereoselective Synthesis of b-Branched Aromatic a-Amino Acids via Biocatalytic Dynamic Kinetic Resolution. Angewandte Chemie (International Ed. in English). PMID 34056805 DOI: 10.1002/anie.202105656  0.756
2021 Renata H. Synthetic utility of oxygenases in site-selective terpenoid functionalization. Journal of Industrial Microbiology & Biotechnology. PMID 33928356 DOI: 10.1093/jimb/kuab002  0.363
2021 Stout CN, Renata H. Reinvigorating the Chiral Pool: Chemoenzymatic Approaches to Complex Peptides and Terpenoids. Accounts of Chemical Research. PMID 33543931 DOI: 10.1021/acs.accounts.0c00823  0.439
2021 Zwick CR, Sosa MB, Renata H. Modular Chemoenzymatic Synthesis of GE81112 B1 and Related Analogues Enables Elucidation of Its Key Pharmacophores. Journal of the American Chemical Society. PMID 33416325 DOI: 10.1021/jacs.0c13424  0.358
2020 Zhang X, King-Smith E, Dong LB, Yang LC, Rudolf JD, Shen B, Renata H. Divergent synthesis of complex diterpenes through a hybrid oxidative approach. Science (New York, N.Y.). 369: 799-806. PMID 32792393 DOI: 10.1126/Science.Abb8271  0.479
2020 Amatuni A, Shuster A, Adibekian A, Renata H. Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I. Cell Chemical Biology. PMID 32763140 DOI: 10.1016/J.Chembiol.2020.07.012  0.453
2020 Li J, Amatuni A, Renata H. Recent advances in the chemoenzymatic synthesis of bioactive natural products. Current Opinion in Chemical Biology. 55: 111-118. PMID 32086167 DOI: 10.1016/J.Cbpa.2020.01.005  0.453
2020 Zwick CR, Renata H. Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis. Natural Product Reports. PMID 32055818 DOI: 10.1039/C9Np00075E  0.409
2020 Li J, Li F, King-Smith E, Renata H. Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids. Nature Chemistry. PMID 31959962 DOI: 10.1038/S41557-019-0407-6  0.761
2019 Zhang X, Renata H. Efficient Chemoenzymatic Synthesis of (2,3)-3-Hydroxy-3-Methylproline, a Key Fragment in Polyoxypeptin A and FR225659. Tetrahedron. 75: 3253-3257. PMID 31885405 DOI: 10.1016/J.Tet.2019.04.009  0.512
2019 Zwick CR, Sosa MB, Renata H. Characterization of a Citrulline 4-Hydroxylase from GE81112 Biosynthesis and Engineering of Its Substrate Specificity for the Chemoenzymatic Synthesis of Enduracididine. Angewandte Chemie (International Ed. in English). PMID 31610076 DOI: 10.1002/Anie.201910659  0.406
2019 Li J, Zhang X, Renata H. Asymmetric Chemoenzymatic Synthesis of (-)-Podophyllotoxin and Related Aryltetralin Lignans. Angewandte Chemie (International Ed. in English). PMID 31241812 DOI: 10.1002/Anie.201904102  0.528
2019 Dong LB, Zhang X, Shen B, Rudolf JD, Deng MR, Kalkreuter E, Cepeda AJ, Renata H. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 30735041 DOI: 10.1021/Jacs.8B13452  0.513
2018 Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp C-H functionalization. Nature. PMID 30568304 DOI: 10.1038/S41586-018-0808-5  0.625
2018 Amatuni A, Renata H. Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential. Organic & Biomolecular Chemistry. PMID 30320324 DOI: 10.1039/C8Ob02054J  0.37
2018 Li F, Zhang X, Renata H. Enzymatic CH functionalizations for natural product synthesis. Current Opinion in Chemical Biology. 49: 25-32. PMID 30269011 DOI: 10.1016/J.Cbpa.2018.09.004  0.743
2018 Rudolf JD, Dong LB, Zhang X, Renata H, Shen B. Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. Journal of the American Chemical Society. PMID 30216060 DOI: 10.1021/Jacs.8B08012  0.507
2018 Zwick CR, Renata H. Evolution of Biocatalytic and Chemocatalytic C-H Functionalization Strategy in the Synthesis of Manzacidin C. The Journal of Organic Chemistry. PMID 29771530 DOI: 10.1021/Acs.Joc.8B00248  0.43
2018 Zhang X, King-Smith E, Renata H. Efficient Total Synthesis of Tambromycin by Interfacing Chemocatalytic and Biocatalytic C-H Functionalization Logic. Angewandte Chemie (International Ed. in English). PMID 29481729 DOI: 10.1002/Anie.201801165  0.505
2018 Zwick CR, Renata H. A one-pot chemoenzymatic synthesis of (2S, 4R)-4-methylproline enables the first total synthesis of antiviral lipopeptide cavinafungin B Tetrahedron. 74: 6469-6473. DOI: 10.1016/J.Tet.2018.09.046  0.451
2017 Zwick CR, Renata H. Remote C-H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs. Journal of the American Chemical Society. PMID 29283572 DOI: 10.1021/Jacs.7B12918  0.494
2017 King-Smith E, Zwick CR, Renata H. Applications of Oxygenases in the Chemoenzymatic Total Synthesis of Complex Natural Products. Biochemistry. PMID 29140086 DOI: 10.1021/Acs.Biochem.7B00998  0.492
2017 Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JK, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. Cell Chemical Biology. PMID 28262559 DOI: 10.1016/J.Chembiol.2017.02.008  0.646
2016 Hernandez KE, Renata H, Lewis RD, Jennifer Kan SB, Zhang C, Forte J, Rozzell D, McIntosh JA, Arnold FH. Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor. Acs Catalysis. 6: 7810-7813. PMID 28286694 DOI: 10.1021/Acscatal.6B02550  0.613
2016 Renata H, Lewis RD, Sweredoski MJ, Moradian A, Hess S, Wang ZJ, Arnold FH. Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. Journal of the American Chemical Society. PMID 27573353 DOI: 10.1021/Jacs.6B06823  0.596
2015 Renata H, Wang ZJ, Arnold FH. Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution. Angewandte Chemie (International Ed. in English). 54: 3351-67. PMID 25649694 DOI: 10.1002/Anie.201409470  0.589
2015 Renata H, Zhou Q, Dünstl G, Felding J, Merchant RR, Yeh CH, Baran PS. Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues. Journal of the American Chemical Society. 137: 1330-40. PMID 25594682 DOI: 10.1021/Ja512022R  0.754
2015 Renata H, Wang ZJ, Arnold FH. Ausdehnung des Enzym-Universums: Zugang zu nicht-natürlichen Reaktionen durch mechanismusgeleitete, gerichtete Evolution Angewandte Chemie. 127: 3408-3426. DOI: 10.1002/Ange.201409470  0.48
2014 Renata H, Wang ZJ, Kitto RZ, Arnold FH. P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. Catalysis Science & Technology. 4: 3640-3643. PMID 25221671 DOI: 10.1039/C4Cy00633J  0.565
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. Angewandte Chemie (International Ed. in English). 53: 6810-3. PMID 24802161 DOI: 10.1002/Anie.201402809  0.76
2014 Wang ZJ, Peck NE, Renata H, Arnold FH. Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds. Chemical Science (Royal Society of Chemistry : 2010). 5: 598-601. PMID 24490022 DOI: 10.1039/C3Sc52535J  0.571
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Cover Picture: Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. Int. Ed. 26/2014) Angewandte Chemie International Edition. 53: 6571-6571. DOI: 10.1002/Anie.201404337  0.763
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Titelbild: Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. 26/2014) Angewandte Chemie. 126: 6689-6689. DOI: 10.1002/Ange.201404337  0.765
2013 Renata H, Zhou Q, Baran PS. Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide. Science (New York, N.Y.). 339: 59-63. PMID 23288535 DOI: 10.1126/Science.1230631  0.724
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