| Year |
Citation |
Score |
| 2023 |
Chen H, Lye MF, Gorgulla C, Ficarro SB, Cuny GD, Scott DA, Wu F, Rothlauf PW, Wang X, Fernandez R, Pesola JM, Draga S, Marto JA, Hogle JM, Arthanari H, et al. A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex. Plos Pathogens. 19: e1011781. PMID 37976321 DOI: 10.1371/journal.ppat.1011781 |
0.3 |
|
| 2021 |
Modi G, Marqus GM, Vippila MR, Gollapalli DR, Kim Y, Manna AC, Chacko S, Maltseva N, Wang X, Cullinane RT, Zhang Y, Kotler JLM, Kuzmic P, Zhang M, Lawson AP, ... ... Cuny GD, et al. The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Infections. Acs Infectious Diseases. PMID 34590817 DOI: 10.1021/acsinfecdis.1c00342 |
0.768 |
|
| 2021 |
Nikhar S, Siokas I, Schlicher L, Lee S, Gyrd-Hansen M, Degterev A, Cuny GD. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. European Journal of Medicinal Chemistry. 215: 113252. PMID 33601309 DOI: 10.1016/j.ejmech.2021.113252 |
0.798 |
|
| 2020 |
Lee S, Ku A, Rao Vippila M, Wang Y, Zhang M, Wang X, Hedstrom L, Cuny GD. Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorganic & Medicinal Chemistry Letters. 127543. PMID 32931912 DOI: 10.1016/J.Bmcl.2020.127543 |
0.795 |
|
| 2020 |
Cuny GD, Degterev A. RIPK protein kinase family: Atypical lives of typical kinases. Seminars in Cell & Developmental Biology. PMID 32732131 DOI: 10.1016/J.Semcdb.2020.06.014 |
0.339 |
|
| 2020 |
Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. European Journal of Medicinal Chemistry. 200: 112417. PMID 32505849 DOI: 10.1016/J.Ejmech.2020.112417 |
0.813 |
|
| 2019 |
Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B. Genetic ablation of purine salvage in reveals nucleotide uptake from the host cell. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570573 DOI: 10.1073/Pnas.1908239116 |
0.329 |
|
| 2019 |
Ali G, Cuny GD. An efficient synthesis of an 8-phenoxy aporphine derivative utilizing mono-ligated palladium ortho-phenol arylation Tetrahedron. 75: 4318-4324. DOI: 10.1016/J.Tet.2019.04.011 |
0.363 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Cuny GD, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.726 |
|
| 2018 |
Jiang JK, Huang X, Shamim K, Patel PR, Lee A, Wang AQ, Nguyen K, Tawa G, Cuny GD, Yu PB, Zheng W, Xu X, Sanderson P, Huang W. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30227946 DOI: 10.1016/J.Bmcl.2018.09.006 |
0.447 |
|
| 2018 |
Ku AF, Cuny GD. Discovery of 7-hydroxyaporphines as conformationally restricted ligands for beta-1 and beta-2 adrenergic receptors. Medchemcomm. 9: 353-356. PMID 30108929 DOI: 10.1039/C7Md00656J |
0.763 |
|
| 2018 |
Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, et al. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. The Embo Journal. PMID 30026309 DOI: 10.15252/Embj.201899372 |
0.762 |
|
| 2018 |
Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L. Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents. Journal of Medicinal Chemistry. PMID 29746130 DOI: 10.1021/Acs.Jmedchem.7B01839 |
0.378 |
|
| 2018 |
Suebsuwong C, Pinkas DM, Ray SS, Bufton JC, Dai B, Bullock AN, Degterev A, Cuny GD. Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29409752 DOI: 10.1016/J.Bmcl.2018.01.044 |
0.808 |
|
| 2017 |
Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, et al. Benzoxazoles, phthalazinones, and arylurea-based compounds with IMPDH-independent antibacterial activity against Francisella tularensis. Antimicrobial Agents and Chemotherapy. PMID 28739786 DOI: 10.1128/Aac.00939-17 |
0.363 |
|
| 2017 |
Cuny GD, Suebsuwong C, Ray SS. Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016). Expert Opinion On Therapeutic Patents. PMID 28074661 DOI: 10.1080/13543776.2017.1280463 |
0.8 |
|
| 2016 |
Ku AF, Cuny GD. Access to 6a-Alkyl Aporphines: Synthesis of (±)-N-Methylguattescidine. The Journal of Organic Chemistry. PMID 27689544 DOI: 10.1021/Acs.Joc.6B02024 |
0.775 |
|
| 2016 |
Vippila MR, Nikhar S, Gracia AP, Cuny GD. Divergent Approach for the Synthesis of Gombamide A and Derivatives. Organic Letters. PMID 27603447 DOI: 10.1021/Acs.Orglett.6B02379 |
0.725 |
|
| 2015 |
Vippila MR, Ly PK, Cuny GD. Synthesis and Antiproliferative Activity Evaluation of the Disulfide-Containing Cyclic Peptide Thiochondrilline C and Derivatives. Journal of Natural Products. 78: 2398-404. PMID 26444379 DOI: 10.1021/Acs.Jnatprod.5B00428 |
0.77 |
|
| 2015 |
Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. Plos One. 10: e0138976. PMID 26440283 DOI: 10.1371/Journal.Pone.0138976 |
0.337 |
|
| 2015 |
Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chemistry & Biology. 22: 1174-84. PMID 26320862 DOI: 10.1016/J.Chembiol.2015.07.017 |
0.803 |
|
| 2015 |
Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking. Bioorganic & Medicinal Chemistry Letters. 25: 2713-9. PMID 25998502 DOI: 10.1016/J.Bmcl.2015.04.027 |
0.42 |
|
| 2015 |
Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallographica. Section F, Structural Biology Communications. 71: 531-8. PMID 25945705 DOI: 10.1107/S2053230X15000187 |
0.425 |
|
| 2015 |
Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Reports. 10: 1850-60. PMID 25801024 DOI: 10.1016/J.Celrep.2015.02.052 |
0.799 |
|
| 2015 |
Ku AF, Cuny GD. Synthetic studies of 7-oxygenated aporphine alkaloids: preparation of (-)-oliveroline, (-)-nornuciferidine, and derivatives. Organic Letters. 17: 1134-7. PMID 25710592 DOI: 10.1021/Acs.Orglett.5B00007 |
0.767 |
|
| 2015 |
Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors Chemistry and Biology. DOI: 10.1016/j.chembiol.2015.07.017 |
0.783 |
|
| 2014 |
Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. Journal of Medicinal Chemistry. 57: 10544-50. PMID 25474504 DOI: 10.1021/Jm501527Z |
0.75 |
|
| 2014 |
Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. Acs Medicinal Chemistry Letters. 5: 846-50. PMID 25147601 DOI: 10.1021/Ml500203P |
0.413 |
|
| 2014 |
Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. Journal of Medicinal Chemistry. 57: 7900-15. PMID 25101911 DOI: 10.1021/Jm501177W |
0.447 |
|
| 2014 |
Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, et al. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. Plos Biology. 12: e1001923. PMID 25093460 DOI: 10.1371/Journal.Pbio.1001923 |
0.356 |
|
| 2014 |
Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. Journal of Biomolecular Screening. 19: 1024-1034. PMID 24598103 DOI: 10.1177/1087057114525853 |
0.383 |
|
| 2014 |
Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrobial Agents and Chemotherapy. 58: 1603-14. PMID 24366728 DOI: 10.1128/Aac.02075-13 |
0.328 |
|
| 2013 |
Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Molecular Cancer Therapeutics. 12: 2651-62. PMID 24130053 DOI: 10.1158/1535-7163.Mct-13-0103-T |
0.435 |
|
| 2013 |
Wang X, Cuny GD, Noël T. A mild, one-pot Stadler-Ziegler synthesis of arylsulfides facilitated by photoredox catalysis in batch and continuous-flow. Angewandte Chemie (International Ed. in English). 52: 7860-4. PMID 23784666 DOI: 10.1002/Anie.201303483 |
0.515 |
|
| 2013 |
Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. The Journal of Biological Chemistry. 288: 22042-56. PMID 23737518 DOI: 10.1074/Jbc.M112.436402 |
0.325 |
|
| 2013 |
Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 56: 4028-43. PMID 23668331 DOI: 10.1021/Jm400241J |
0.456 |
|
| 2013 |
Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. Plos One. 8: e62721. PMID 23646137 DOI: 10.1371/Journal.Pone.0062721 |
0.43 |
|
| 2013 |
Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Development of an ALK2-biased BMP type I receptor kinase inhibitor. Acs Chemical Biology. 8: 1291-302. PMID 23547776 DOI: 10.1021/Cb300655W |
0.416 |
|
| 2013 |
Maki JL, Tres Brazell J, Teng X, Cuny GD, Degterev A. Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expression and Purification. 89: 156-61. PMID 23523699 DOI: 10.1016/J.Pep.2013.03.002 |
0.382 |
|
| 2013 |
McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach A, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. Plos One. 8: e56576. PMID 23469174 DOI: 10.1371/Journal.Pone.0056576 |
0.382 |
|
| 2013 |
Liu M, Bender SA, Cuny GD, Sherman W, Glicksman M, Ray SS. Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry. 52: 1725-36. PMID 23379419 DOI: 10.1021/Bi3012077 |
0.354 |
|
| 2013 |
Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorganic & Medicinal Chemistry Letters. 23: 1004-7. PMID 23324406 DOI: 10.1016/J.Bmcl.2012.12.037 |
0.442 |
|
| 2013 |
Mistry H, Hsieh G, Buhrlage S, Huang M, Park E, Cuny G, Galinsky I, Stone RM, Gray NS, Parmar K, D'Andrea AD. Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity Blood. 122: 2906-2906. DOI: 10.1182/Blood.V122.21.2906.2906 |
0.439 |
|
| 2012 |
Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 55: 7759-71. PMID 22950983 DOI: 10.1021/Jm3007917 |
0.362 |
|
| 2012 |
Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorganic & Medicinal Chemistry Letters. 22: 5685-8. PMID 22832318 DOI: 10.1016/J.Bmcl.2012.06.098 |
0.407 |
|
| 2012 |
Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Analytical Biochemistry. 427: 164-74. PMID 22658960 DOI: 10.1016/J.Ab.2012.05.019 |
0.436 |
|
| 2012 |
Wright PD, Wightman N, Huang M, Weiss A, Sapp PC, Cuny GD, Ivinson AJ, Glicksman MA, Ferrante RJ, Matson W, Matson S, Brown RH. A high-throughput screen to identify inhibitors of SOD1 transcription. Frontiers in Bioscience (Elite Edition). 4: 2801-8. PMID 22652679 DOI: 10.2741/E584 |
0.338 |
|
| 2012 |
Hellal M, Singh S, Cuny GD. Synthesis of tetracyclic indoles via intramolecular α-arylation of ketones. The Journal of Organic Chemistry. 77: 4123-30. PMID 22480284 DOI: 10.1021/Jo300052Z |
0.306 |
|
| 2012 |
Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov DA, Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Research. 94: 18-24. PMID 22343093 DOI: 10.1016/J.Antiviral.2012.02.003 |
0.434 |
|
| 2012 |
Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2015-9. PMID 22335895 DOI: 10.1016/J.Bmcl.2012.01.028 |
0.432 |
|
| 2012 |
Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorganic & Medicinal Chemistry Letters. 22: 1985-8. PMID 22310229 DOI: 10.1016/J.Bmcl.2012.01.029 |
0.439 |
|
| 2012 |
Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesthesia and Analgesia. 115: 297-304. PMID 21965364 DOI: 10.1213/Ane.0B013E3182320559 |
0.309 |
|
| 2012 |
King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. The Biochemical Journal. 441: 453-61. PMID 21939436 DOI: 10.1042/Bj20101909 |
0.337 |
|
| 2012 |
Maki JL, Teng X, Smith EE, Ray S, Yuan J, Cuny GD, Degterev A. Abstract SY27-03: Development of necrostatins, small molecule inhibitors of RIP1-kinase signaling and necroptosis Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy27-03 |
0.447 |
|
| 2011 |
Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry. 50: 9399-408. PMID 21961647 DOI: 10.1021/Bi201173D |
0.354 |
|
| 2011 |
Laha JK, Cuny GD. Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter α to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. The Journal of Organic Chemistry. 76: 8477-82. PMID 21913645 DOI: 10.1021/Jo201237H |
0.357 |
|
| 2011 |
Laha JK, Barolo SM, Rossi RA, Cuny GD. Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines. The Journal of Organic Chemistry. 76: 6421-5. PMID 21739958 DOI: 10.1021/Jo200923N |
0.321 |
|
| 2011 |
Laha JK, Zhang X, Qiao L, Liu M, Chatterjee S, Robinson S, Kosik KS, Cuny GD. Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 2098-101. PMID 21353545 DOI: 10.1016/J.Bmcl.2011.01.140 |
0.374 |
|
| 2010 |
Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18: 382-95. PMID 20951947 DOI: 10.1016/J.Ccr.2010.08.010 |
0.37 |
|
| 2010 |
Hellal M, Cuny GD. Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione. Organic Letters. 12: 4628-31. PMID 20845915 DOI: 10.1021/Ol101890T |
0.306 |
|
| 2010 |
Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 3491-4. PMID 20836251 DOI: 10.1016/J.Bmcl.2010.04.150 |
0.462 |
|
| 2010 |
Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors. Analytical Biochemistry. 404: 186-92. PMID 20566370 DOI: 10.1016/J.Ab.2010.05.033 |
0.432 |
|
| 2010 |
Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, ... ... Cuny GD, et al. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One. 5: e10504. PMID 20498699 DOI: 10.1371/Journal.Pone.0010504 |
0.381 |
|
| 2010 |
Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. Journal of Medicinal Chemistry. 53: 2709-18. PMID 20232802 DOI: 10.1021/Jm901062P |
0.301 |
|
| 2010 |
Ouertatani-Sakouhi H, Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA. Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. Journal of Biomolecular Screening. 15: 347-58. PMID 20231420 DOI: 10.1177/1087057110363825 |
0.407 |
|
| 2010 |
Lee K, Campbell J, Swoboda JG, Cuny GD, Walker S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorganic & Medicinal Chemistry Letters. 20: 1767-70. PMID 20138521 DOI: 10.1016/J.Bmcl.2010.01.036 |
0.372 |
|
| 2010 |
Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. Journal of the American Chemical Society. 132: 1230-1. PMID 20052976 DOI: 10.1021/Ja909947A |
0.375 |
|
| 2010 |
JOHNSON JR, CUNY GD, BUCHWALD SL. ChemInform Abstract: Rhodium-Catalyzed Hydroformylation of Internal Alkynes to α,. beta.-Unsaturated Aldehydes. Cheminform. 26: no-no. DOI: 10.1002/chin.199548084 |
0.329 |
|
| 2010 |
CUNY GD, BUCHWALD SL. ChemInform Abstract: Regioselective Olefin Hydroformylation as a Route to Indolizidine and Pyrrolizidine Alkaloids. Cheminform. 26: no-no. DOI: 10.1002/chin.199540237 |
0.336 |
|
| 2010 |
CUNY GD, BUCHWALD SL. ChemInform Abstract: Practical, High-Yield, Regioselective, Rhodium-Catalyzed Hydroformylation of Functionalized α-Olefins. Cheminform. 24: no-no. DOI: 10.1002/chin.199330120 |
0.336 |
|
| 2010 |
CUNY GD, GUTIERREZ A, BUCHWALD SL. ChemInform Abstract: Cis Difunctionalization of Cyclic Olefins with Use of Organozirconium Intermediates. Cheminform. 22: no-no. DOI: 10.1002/chin.199129138 |
0.306 |
|
| 2010 |
CUNY GD, BUCHWALD SL. ChemInform Abstract: Ring-Opening Reactions of Cyclic Allylic Ethers by Zirconocene Complexes of Cyclic Alkynes. Cheminform. 22: no-no. DOI: 10.1002/chin.199117054 |
0.353 |
|
| 2009 |
Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6122-6. PMID 19783434 DOI: 10.1016/J.Bmcl.2009.09.010 |
0.428 |
|
| 2009 |
Cuny GD. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Current Pharmaceutical Design. 15: 3919-39. PMID 19751204 DOI: 10.2174/138161209789649330 |
0.386 |
|
| 2009 |
Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. Journal of Medicinal Chemistry. 52: 4623-30. PMID 19624136 DOI: 10.1021/Jm900410U |
0.433 |
|
| 2009 |
Cuny GD. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466. Expert Opinion On Therapeutic Patents. 19: 893-9. PMID 19473108 DOI: 10.1517/13543770902766829 |
0.31 |
|
| 2009 |
Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. Journal of Immunology (Baltimore, Md. : 1950). 182: 6342-52. PMID 19414787 DOI: 10.4049/Jimmunol.0803464 |
0.311 |
|
| 2009 |
Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. Plos One. 4: e5274. PMID 19384407 DOI: 10.1371/Journal.Pone.0005274 |
0.375 |
|
| 2008 |
Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nature Medicine. 14: 1363-9. PMID 19029982 DOI: 10.1038/Nm.1888 |
0.347 |
|
| 2008 |
Patnaik D, Jun Xian, Glicksman MA, Cuny GD, Stein RL, Higgins JM. Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. Journal of Biomolecular Screening. 13: 1025-34. PMID 18978305 DOI: 10.1177/1087057108326081 |
0.397 |
|
| 2008 |
Wagle N, Xian J, Shishova EY, Wei J, Glicksman MA, Cuny GD, Stein RL, Cohen DE. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Analytical Biochemistry. 383: 85-92. PMID 18762160 DOI: 10.1016/J.Ab.2008.07.039 |
0.36 |
|
| 2008 |
Liu M, Choi S, Cuny GD, Ding K, Dobson BC, Glicksman MA, Auerbach K, Stein RL. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. 47: 8367-77. PMID 18636751 DOI: 10.1021/Bi800732V |
0.387 |
|
| 2008 |
Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 4388-92. PMID 18621530 DOI: 10.1016/J.Bmcl.2008.06.052 |
0.398 |
|
| 2008 |
Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3219-23. PMID 18467094 DOI: 10.1016/J.Bmcl.2008.04.048 |
0.399 |
|
| 2008 |
Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/Nchembio.83 |
0.394 |
|
| 2008 |
Laha JK, Cuny GD. Synthesis of tetrazolo[1,5-a]pyridines utilizing trimethylsilyl azide and tetrabutylammonium fluoride hydrate Synthesis. 4002-4006. DOI: 10.1055/S-0028-1083233 |
0.313 |
|
| 2008 |
VISWANATHAN P, MUELLER N, PATTABIRAMAN N, LEE K, CUNY G, TAKHAMPUNYA R, ANSARAHSABRINO C, PIERSON T, PADMANABHAN R. Characterization of Small Molecule Inhibitors of West Nile Virus NS3 Serine Protease Antiviral Research. 78: A50-A50. DOI: 10.1016/J.Antiviral.2008.01.102 |
0.33 |
|
| 2007 |
Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS. New approaches to the discovery of cdk5 inhibitors. Current Alzheimer Research. 4: 547-9. PMID 18220519 DOI: 10.2174/156720507783018181 |
0.413 |
|
| 2007 |
Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 6836-40. PMID 17964153 DOI: 10.1016/J.Bmcl.2007.10.024 |
0.375 |
|
| 2007 |
Mermerian AH, Case A, Stein RL, Cuny GD. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 3729-32. PMID 17449248 DOI: 10.1016/J.Bmcl.2007.04.027 |
0.375 |
|
| 2007 |
Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. Journal of Medicinal Chemistry. 50: 1886-95. PMID 17361994 DOI: 10.1021/Jm061016O |
0.381 |
|
| 2006 |
Barolo SM, Teng X, Cuny GD, Rossi RA. Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. The Journal of Organic Chemistry. 71: 8493-9. PMID 17064025 DOI: 10.1021/Jo061478+ |
0.301 |
|
| 2006 |
Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. Small molecules that enhance the catalytic efficiency of HLA-DM. Journal of Immunology (Baltimore, Md. : 1950). 176: 4208-20. PMID 16547258 DOI: 10.4049/Jimmunol.176.7.4208 |
0.331 |
|
| 2005 |
Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology. 1: 112-9. PMID 16408008 DOI: 10.1038/Nchembio711 |
0.316 |
|
| 2005 |
Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 5039-44. PMID 16153840 DOI: 10.1016/J.Bmcl.2005.07.077 |
0.401 |
|
| 2005 |
Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chemistry & Biology. 12: 811-23. PMID 16039528 DOI: 10.1016/J.Chembiol.2005.05.011 |
0.408 |
|
| 2005 |
Duval E, Case A, Stein RL, Cuny GD. Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorganic & Medicinal Chemistry Letters. 15: 1885-9. PMID 15780627 DOI: 10.1016/J.Bmcl.2005.02.005 |
0.355 |
|
| 2004 |
Duval E, Cuny GD. Synthesis of substituted carbazoles and β-carbolines by cyclization of diketoindole derivatives Tetrahedron Letters. 45: 5411-5413. DOI: 10.1016/J.Tetlet.2004.05.053 |
0.301 |
|
| 2004 |
Cuny GD. Synthesis of (±)-aporphine utilizing Pictet-Spengler and intramolecular phenol ortho-arylation reactions Tetrahedron Letters. 45: 5167-5170. DOI: 10.1016/J.Tetlet.2004.04.194 |
0.32 |
|
| 2003 |
Xing X, Ho P, Bourquin G, Yeh LA, Cuny GD. Synthesis, stereochemistry confirmation and biological activity evaluation of a constituent from Isodon excisus Tetrahedron. 59: 9961-9969. DOI: 10.1016/J.Tet.2003.10.025 |
0.392 |
|
| 2002 |
Xing X, Padmanaban D, Yeh LA, Cuny GD. Utilization of a copper-catalyzed diaryl ether synthesis for the preparation of verbenachalcone Tetrahedron. 58: 7903-7910. DOI: 10.1016/S0040-4020(02)00915-8 |
0.339 |
|
| 1995 |
Cuny GD, Buchwald SL. Regioselective Olefin Hydroformylation as a Route to Indolizidine and Pyrrolizidine Alkaloids Synlett. 1995: 519-522. DOI: 10.1055/S-1995-5273 |
0.344 |
|
| 1995 |
Johnson JR, Cuny GD, Buchwald SL. Rhodium-Catalyzed Hydroformylation of Internal Alkynes toα,β-Unsaturated Aldehydes Angewandte Chemie International Edition in English. 34: 1760-1761. DOI: 10.1002/Anie.199517601 |
0.33 |
|
| 1995 |
Johnson JR, Cuny GD, Buchwald SL. Rhodium-katalysierte Hydroformylierung innerer Alkine zu α,β-ungesättigten Aldehyden Angewandte Chemie. 107: 1877-1879. DOI: 10.1002/Ange.19951071613 |
0.303 |
|
| 1993 |
Cuny G, Buchwald S. Correction. Practical, High-Yield, Regioselective, Rhodium-Catalyzed Hydroformylation of Functionalized α-Olefins Journal of the American Chemical Society. 115: 8885-8885. DOI: 10.1021/Ja00072A601 |
0.418 |
|
| 1993 |
Cuny GD, Buchwald SL. Practical, high-yield, regioselective, rhodium-catalyzed hydroformylation of functionalized .alpha.-olefins Journal of the American Chemical Society. 115: 2066-2068. DOI: 10.1021/Ja00058A079 |
0.314 |
|
| 1991 |
Cuny GD, Gutierrez A, Buchwald SL. Cis difunctionalization of cyclic olefins with use of organozirconium intermediates Organometallics. 10: 537-539. DOI: 10.1021/Om00049A006 |
0.346 |
|
| 1991 |
Cuny GD, Buchwald SL. Ring-opening reactions of cyclic allylic ethers by zirconocene complexes of cyclic alkynes Organometallics. 10: 363-365. DOI: 10.1021/Om00047A076 |
0.353 |
|
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