Anna Philpott - Publications

Affiliations: 
2007-2011 Oncology University of Cambridge, Hutchison/MRC Research Centre 

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ali FR, Marcos D, Chernukhin I, Woods LM, Parkinson LM, Wylie LA, Papkovskaia TD, Davies JD, Carroll JS, Philpott A. Dephosphorylation of the proneural transcription factor ASCL1 re-engages a latent post-mitotic differentiation programme in neuroblastoma. Molecular Cancer Research : McR. PMID 33046535 DOI: 10.1158/1541-7786.MCR-20-0693  1
2020 Sznurkowska MK, Hannezo E, Azzarelli R, Chatzeli L, Ikeda T, Yoshida S, Philpott A, Simons BD. Tracing the cellular basis of islet specification in mouse pancreas. Nature Communications. 11: 5037. PMID 33028844 DOI: 10.1038/s41467-020-18837-3  1
2019 Hardwick LJA, Philpott A. Analysis of Chromatin Binding of Ectopically Expressed Proteins in Early Embryos. Cold Spring Harbor Protocols. PMID 31138717 DOI: 10.1101/pdb.prot105577  1
2019 Hardwick LJA, Philpott A. Analysis of Phosphorylation Status of Ectopically Expressed Proteins in Early Embryos. Cold Spring Harbor Protocols. PMID 31138716 DOI: 10.1101/pdb.prot105569  1
2019 Hardwick LJA, Davies JD, Philpott A. Multi-site phosphorylation controls the neurogenic and myogenic activity of E47. Biochemical and Biophysical Research Communications. 511: 111-116. PMID 30773262 DOI: 10.1016/j.bbrc.2019.02.045  1
2019 Hardwick LJA, Philpott A. N-terminal phosphorylation of xHes1 controls inhibition of primary neurogenesis in Xenopus. Biochemical and Biophysical Research Communications. 509: 557-563. PMID 30600182 DOI: 10.1016/j.bbrc.2018.12.135  1
2018 Hardwick LJA, Philpott A. Models of Cancer: Expanding the Oncologist's Toolbox. Frontiers in Physiology. 9: 1660. PMID 30538639 DOI: 10.3389/fphys.2018.01660  1
2018 Hardwick LJA, Philpott A. Interaction between opposing modes of phospho-regulation of the proneural proteins Ascl1 and Ngn2. Wellcome Open Research. 3: 129. PMID 30430141 DOI: 10.12688/wellcomeopenres.14848.1  1
2018 Hardwick LJA, Philpott A. The N terminus of Ascl1 underlies differing proneural activity of mouse and Ascl1 proteins. Wellcome Open Research. 3: 125. PMID 30363793 DOI: 10.12688/wellcomeopenres.14842.1  1
2018 Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, Bonfanti P, Göttgens B, Huch M, Simons B, Philpott A. Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells. Scientific Reports. 8: 15374. PMID 30337647 DOI: 10.1038/s41598-018-33838-5  1
2018 Hardwick LJA, Azzarelli R, Philpott A. Cell cycle-dependent phosphorylation and regulation of cellular differentiation. Biochemical Society Transactions. PMID 30242121 DOI: 10.1042/BST20180276  1
2018 Tomic G, Morrissey E, Kozar S, Ben-Moshe S, Hoyle A, Azzarelli R, Kemp R, Chilamakuri CSR, Itzkovitz S, Philpott A, Winton DJ. Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. Cell Stem Cell. PMID 30100168 DOI: 10.1016/j.stem.2018.07.002  1
2018 Sznurkowska MK, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley CJ, Nichols J, Göttgens B, Huch M, Philpott A, Simons BD. Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development. Developmental Cell. PMID 30057275 DOI: 10.1016/j.devcel.2018.06.028  1
2018 McDowell GS, Philpott A. Calculating the Degradation Rate of Individual Proteins Using Extract Systems. Cold Spring Harbor Protocols. PMID 29769400 DOI: 10.1101/pdb.prot103481  1
2018 McDowell GS, Philpott A. Assessing Ubiquitylation of Individual Proteins Using Extract Systems. Cold Spring Harbor Protocols. PMID 29769387 DOI: 10.1101/pdb.prot104513  1
2018 Azzarelli R, Simons BD, Philpott A. The developmental origin of brain tumours: a cellular and molecular framework. Development (Cambridge, England). 145. PMID 29759978 DOI: 10.1242/dev.162693  1
2018 Rulands S, Lescroart F, Chabab S, Hindley CJ, Prior N, Sznurkowska MK, Huch M, Philpott A, Blanpain C, Simons BD. Universality of clone dynamics during tissue development. Nature Physics. 14: 469-474. PMID 29736183 DOI: 10.1038/s41567-018-0055-6  1
2017 Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, ... ... Philpott A, et al. Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation. Developmental Cell. PMID 28457793 DOI: 10.1016/j.devcel.2017.04.004  1
2016 McDowell GS, Philpott A. Ubiquitin-mediated proteolysis in Xenopus extract. The International Journal of Developmental Biology. PMID 27528041 DOI: 10.1387/ijdb.160186gm  1
2016 McDowell GS, Philpott A. New Insights Into the Role of Ubiquitylation of Proteins. International Review of Cell and Molecular Biology. 325: 35-88. PMID 27241218 DOI: 10.1016/bs.ircmb.2016.02.002  1
2016 McDowell GS, Philpott A. New Insights Into the Role of Ubiquitylation of Proteins International Review of Cell and Molecular Biology. DOI: 10.1016/bs.ircmb.2016.02.002  1
2015 Hardwick LJ, Philpott A. Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins. Neural Development. 10: 15. PMID 26084567 DOI: 10.1186/s13064-015-0044-8  1
2015 Wylie LA, Hardwick LJ, Papkovskaia TD, Thiele CJ, Philpott A. Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma. Disease Models & Mechanisms. 8: 429-41. PMID 25786414 DOI: 10.1242/dmm.018630  1
2015 Hardwick LJ, Philpott A. An oncologist׳s friend: How Xenopus contributes to cancer research. Developmental Biology. PMID 25704511 DOI: 10.1016/j.ydbio.2015.02.003  1
2015 Azzarelli R, Hardwick LJ, Philpott A. Emergence of neuronal diversity from patterning of telencephalic progenitors. Wiley Interdisciplinary Reviews. Developmental Biology. 4: 197-214. PMID 25619507 DOI: 10.1002/wdev.174  1
2015 Hardwick LJ, Ali FR, Azzarelli R, Philpott A. Cell cycle regulation of proliferation versus differentiation in the central nervous system. Cell and Tissue Research. 359: 187-200. PMID 24859217 DOI: 10.1007/s00441-014-1895-8  1
2014 McDowell GS, Hindley CJ, Lippens G, Landrieu I, Philpott A. Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. Bmc Biochemistry. 15: 24. PMID 25374254 DOI: 10.1186/s12858-014-0024-3  1
2014 Philpott A, Winton DJ. Lineage selection and plasticity in the intestinal crypt. Current Opinion in Cell Biology. 31: 39-45. PMID 25083805 DOI: 10.1016/j.ceb.2014.07.002  1
2014 McDowell GS, Hardwick LJ, Philpott A. Complex domain interactions regulate stability and activity of closely related proneural transcription factors. Biochemical and Biophysical Research Communications. 450: 1283-90. PMID 24998442 DOI: 10.1016/j.bbrc.2014.06.127  1
2014 Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development (Cambridge, England). 141: 2216-24. PMID 24821983 DOI: 10.1242/dev.106377  1
2014 Hardwick LJ, Philpott A. Nervous decision-making: to divide or differentiate. Trends in Genetics : Tig. 30: 254-61. PMID 24791612 DOI: 10.1016/j.tig.2014.04.001  1
2013 McDowell GS, Philpott A. Non-canonical ubiquitylation: mechanisms and consequences. The International Journal of Biochemistry & Cell Biology. 45: 1833-42. PMID 23732108 DOI: 10.1016/j.biocel.2013.05.026  1
2013 Hindley C, Philpott A. The cell cycle and pluripotency. The Biochemical Journal. 451: 135-43. PMID 23535166 DOI: 10.1042/BJ20121627  1
2012 Hindley C, Philpott A. Co-ordination of cell cycle and differentiation in the developing nervous system. The Biochemical Journal. 444: 375-82. PMID 22642576 DOI: 10.1042/BJ20112040  1
2012 Hindley C, Ali F, McDowell G, Cheng K, Jones A, Guillemot F, Philpott A. Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development (Cambridge, England). 139: 1718-23. PMID 22491944 DOI: 10.1242/dev.077552  1
2012 Wylie L, Philpott A. Neuroblastoma progress on many fronts: the Neuroblastoma Research Symposium. Pediatric Blood & Cancer. 58: 649-51. PMID 21922652 DOI: 10.1002/pbc.23329  1
2011 Murai K, Philpott A, Jones PH. Hes6 is required for the neurogenic activity of neurogenin and NeuroD. Plos One. 6: e27880. PMID 22114720 DOI: 10.1371/journal.pone.0027880  1
2011 Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development (Cambridge, England). 138: 4267-77. PMID 21852393 DOI: 10.1242/dev.067900  1
2011 Hindley CJ, McDowell GS, Wise H, Philpott A. Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases. The International Journal of Developmental Biology. 55: 249-60. PMID 21710433 DOI: 10.1387/ijdb.103171ch  1
2010 McDowell GS, Kucerova R, Philpott A. Non-canonical ubiquitylation of the proneural protein Ngn2 occurs in both Xenopus embryos and mammalian cells. Biochemical and Biophysical Research Communications. 400: 655-60. PMID 20807509 DOI: 10.1016/j.bbrc.2010.08.122  1
2010 Almeida AD, Wise HM, Hindley CJ, Slevin MK, Hartley RS, Philpott A. The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis. Neural Development. 5: 1. PMID 20047651 DOI: 10.1186/1749-8104-5-1  1
2009 Naylor RW, Collins RJ, Philpott A, Jones EA. Normal levels of p27 are necessary for somite segmentation and determining pronephric organ size. Organogenesis. 5: 201-10. PMID 20539739  1
2009 Vosper JM, McDowell GS, Hindley CJ, Fiore-Heriche CS, Kucerova R, Horan I, Philpott A. Ubiquitylation on canonical and non-canonical sites targets the transcription factor neurogenin for ubiquitin-mediated proteolysis. The Journal of Biological Chemistry. 284: 15458-68. PMID 19336407 DOI: 10.1074/jbc.M809366200  1
2009 Naylor RW, Collins RJ, Philpott A, Jones EA. Normal levels of p27Xic1 are necessary for somite segmentation and determining pronephric organ size Organogenesis. 5.  1
2008 Movassagh M, Philpott A. Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1. Cardiovascular Research. 79: 436-47. PMID 18442987 DOI: 10.1093/cvr/cvn105  1
2008 Philpott A. Division versus differentiation in the early Xenopus embryo. Seb Experimental Biology Series. 59: 145-65. PMID 18368922  1
2008 Philpott A, Yew PR. The Xenopus cell cycle: an overview. Molecular Biotechnology. 39: 9-19. PMID 18266114 DOI: 10.1007/s12033-008-9033-z  1
2007 Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F. [p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex]. Bulletin Et MéMoires De L'AcadéMie Royale De MéDecine De Belgique. 162: 310-4. PMID 18405000  1
2007 Boix-Perales H, Horan I, Wise H, Lin HR, Chuang LC, Yew PR, Philpott A. The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle. Neural Development. 2: 27. PMID 18081928 DOI: 10.1186/1749-8104-2-27  1
2007 Murai K, Vernon AE, Philpott A, Jones P. Hes6 is required for MyoD induction during gastrulation. Developmental Biology. 312: 61-76. PMID 17950722 DOI: 10.1016/j.ydbio.2007.09.011  1
2007 Vosper JM, Fiore-Heriche CS, Horan I, Wilson K, Wise H, Philpott A. Regulation of neurogenin stability by ubiquitin-mediated proteolysis. The Biochemical Journal. 407: 277-84. PMID 17623011 DOI: 10.1042/BJ20070064  1
2007 Cosgrove RA, Philpott A. Cell cycling and differentiation do not require the retinoblastoma protein during early Xenopus development. Developmental Biology. 303: 311-24. PMID 17188261 DOI: 10.1016/j.ydbio.2006.11.015  1
2006 Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F. p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes & Development. 20: 1511-24. PMID 16705040 DOI: 10.1101/gad.377106  1
2006 Vernon AE, Movassagh M, Horan I, Wise H, Ohnuma S, Philpott A. Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons. Embo Reports. 7: 643-8. PMID 16648822 DOI: 10.1038/sj.embor.7400691  1
2006 Lin HR, Chuang LC, Boix-Perales H, Philpott A, Yew PR. Ubiquitination of cyclin-dependent kinase inhibitor, Xic1, is mediated by the Xenopus F-box protein xSkp2. Cell Cycle (Georgetown, Tex.). 5: 304-14. PMID 16410731  1
2005 Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell. 121: 887-98. PMID 15960976 DOI: 10.1016/j.cell.2005.05.015  1
2005 Philpott A, Yew PR. The Xenopus cell cycle: an overview. Methods in Molecular Biology (Clifton, N.J.). 296: 95-112. PMID 15576928  1
2004 Richard-Parpaillon L, Cosgrove RA, Devine C, Vernon AE, Philpott A. G1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation in Xenopus. Development (Cambridge, England). 131: 2577-86. PMID 15115752 DOI: 10.1242/dev.01121  1
2003 Vernon AE, Philpott A. The developmental expression of cell cycle regulators in Xenopus laevis. Gene Expression Patterns : Gep. 3: 179-92. PMID 12711547 DOI: 10.1016/S1567-133X(03)00006-1  1
2003 Cremisi F, Philpott A, Ohnuma S. Cell cycle and cell fate interactions in neural development. Current Opinion in Neurobiology. 13: 26-33. PMID 12593979 DOI: 10.1016/S0959-4388(03)00005-9  1
2003 Vernon AE, Devine C, Philpott A. The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. Development (Cambridge, England). 130: 85-92. PMID 12441293 DOI: 10.1242/dev.00193  1
2003 Vernon AE, Philpott A. A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus. Development (Cambridge, England). 130: 71-83. PMID 12441292 DOI: 10.1242/dev.00180  1
2002 Ohnuma S, Hopper S, Wang KC, Philpott A, Harris WA. Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina. Development (Cambridge, England). 129: 2435-46. PMID 11973275  1
2002 Cossins J, Vernon AE, Zhang Y, Philpott A, Jones PH. Hes6 regulates myogenic differentiation. Development (Cambridge, England). 129: 2195-207. PMID 11959828  1
2002 Richard-Parpaillon L, Héligon C, Chesnel F, Boujard D, Philpott A. The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus. Developmental Biology. 244: 407-17. PMID 11944947 DOI: 10.1006/dbio.2002.0605  1
2001 Lücke CD, Philpott A, Metcalfe JC, Thompson AM, Hughes-Davies L, Kemp PR, Hesketh R. Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer. Cancer Research. 61: 482-5. PMID 11212236  1
2001 Ohnuma S, Philpott A, Harris WA. Cell cycle and cell fate in the nervous system. Current Opinion in Neurobiology. 11: 66-73. PMID 11179874 DOI: 10.1016/S0959-4388(00)00175-6  1
2000 Philpott A, Krude T, Laskey RA. Nuclear chaperones. Seminars in Cell & Developmental Biology. 11: 7-14. PMID 10736259 DOI: 10.1006/scdb.1999.0346  1
1999 Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA. p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell. 99: 499-510. PMID 10589678  1
1999 Zuber ME, Perron M, Philpott A, Bang A, Harris WA. Giant eyes in Xenopus laevis by overexpression of XOptx2. Cell. 98: 341-52. PMID 10458609 DOI: 10.1016/S0092-8674(00)81963-7  1
1999 Philpott A, Tsai L, Kirschner MW. Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. Developmental Biology. 207: 119-32. PMID 10049569 DOI: 10.1006/dbio.1998.9146  1
1997 Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes & Development. 11: 1409-21. PMID 9192869  1
1997 Crevel G, Huikeshoven H, Cotterill S, Simon M, Wall J, Philpott A, Laskey RA, McConnell M, Fisher PA, Berrios M. Molecular and cellular characterization of CRP1, a Drosophila chromatin decondensation protein. Journal of Structural Biology. 118: 9-22. PMID 9087911 DOI: 10.1006/jsbi.1996.3836  1
1996 Leno GH, Mills AD, Philpott A, Laskey RA. Hyperphosphorylation of nucleoplasmin facilitates Xenopus sperm decondensation at fertilization. The Journal of Biological Chemistry. 271: 7253-6. PMID 8631735 DOI: 10.1074/jbc.271.13.7253  1
1994 Kawasaki K, Philpott A, Avilion AA, Berrios M, Fisher PA. Chromatin decondensation in Drosophila embryo extracts. The Journal of Biological Chemistry. 269: 10169-76. PMID 8144519  1
1994 Philpott A, Friend SH. E2F and its developmental regulation in Xenopus laevis. Molecular and Cellular Biology. 14: 5000-9. PMID 8007993  1
1993 Laskey RA, Mills AD, Philpott A, Leno GH, Dilworth SM, Dingwall C. The role of nucleoplasmin in chromatin assembly and disassembly. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 339: 263-9; discussion 26. PMID 8098530 DOI: 10.1098/rstb.1993.0024  1
1992 Philpott A, Leno GH. Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts. Cell. 69: 759-67. PMID 1591776 DOI: 10.1016/0092-8674(92)90288-N  1
1991 Philpott A, Leno GH, Laskey RA. Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin. Cell. 65: 569-78. PMID 2032284 DOI: 10.1016/0092-8674(91)90089-H  1
1991 Laskey RA, Cox LS, Leno GH, Philpott A, Mills AD, Sleeman AM. Control of DNA replication in reconstituted nuclei. Cold Spring Harbor Symposia On Quantitative Biology. 56: 347-52. PMID 1819495  1
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