| Year |
Citation |
Score |
| 2023 |
De Luca L, Lombardo L, Mirabile S, Marrazzo A, Dichiara M, Cosentino G, Amata E, Gitto R. Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity. Rsc Medicinal Chemistry. 14: 1734-1742. PMID 37731701 DOI: 10.1039/d3md00291h |
0.318 |
|
| 2023 |
Barbaraci C, di Giacomo V, Maruca A, Patamia V, Rocca R, Dichiara M, Di Rienzo A, Cacciatore I, Cataldi A, Balaha M, Rapino M, Zagni C, Zampieri D, Pasquinucci L, Parenti C, ... Amata E, et al. Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity. Bioorganic Chemistry. 140: 106794. PMID 37659146 DOI: 10.1016/j.bioorg.2023.106794 |
0.367 |
|
| 2021 |
Romeo G, Ciaffaglione V, Amata E, Dichiara M, Calabrese L, Vanella L, Sorrenti V, Grosso S, D'Amico AG, D'Agata V, Intagliata S, Salerno L. Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity. Molecules (Basel, Switzerland). 26. PMID 34202711 DOI: 10.3390/molecules26133860 |
0.323 |
|
| 2021 |
Romeo G, Ciaffaglione V, Amata E, Dichiara M, Calabrese L, Vanella L, Sorrenti V, Grosso S, D'Amico AG, D'Agata V, Intagliata S, Salerno L. Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity. Molecules (Basel, Switzerland). 26. PMID 34202711 DOI: 10.3390/molecules26133860 |
0.323 |
|
| 2020 |
Amata E, Dichiara M, Gentile D, Marrazzo A, Turnaturi R, Arena E, La Mantia A, Tomasello BR, Acquaviva R, Di Giacomo C, Rescifina A, Prezzavento O. Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation. Acs Medicinal Chemistry Letters. 11: 889-894. PMID 32435401 DOI: 10.1021/Acsmedchemlett.9B00661 |
0.406 |
|
| 2020 |
Pasquinucci L, Parenti C, Ruiz-Cantero MC, Georgoussi Z, Pallaki P, Cobos EJ, Amata E, Marrazzo A, Prezzavento O, Arena E, Dichiara M, Salerno L, Turnaturi R. Novel -Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists. Acs Medicinal Chemistry Letters. 11: 678-685. PMID 32435370 DOI: 10.1021/Acsmedchemlett.9B00549 |
0.407 |
|
| 2019 |
Intagliata S, Salerno L, Ciaffaglione V, Leonardi C, Fallica AN, Carota G, Amata E, Marrazzo A, Pittalà V, Romeo G. Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors. European Journal of Medicinal Chemistry. 183: 111703. PMID 31550661 DOI: 10.1016/J.Ejmech.2019.111703 |
0.411 |
|
| 2019 |
Romeo G, Salerno L, Pittalà V, Candido M, Intagliata S, Amata E, Salmona M, Cagnotto A, Rescifina A, Floresta G, Modica MN. [1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT receptor. European Journal of Medicinal Chemistry. 183: 111690. PMID 31526973 DOI: 10.1016/J.Ejmech.2019.111690 |
0.36 |
|
| 2019 |
Floresta G, Amata E, Gentile D, Romeo G, Marrazzo A, Pittalà V, Salerno L, Rescifina A. Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products. Marine Drugs. 17. PMID 30759842 DOI: 10.3390/Md17020113 |
0.401 |
|
| 2019 |
Floresta G, Dichiara M, Gentile D, Prezzavento O, Marrazzo A, Rescifina A, Amata E. Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands. International Journal of Molecular Sciences. 20. PMID 30678129 DOI: 10.3390/Ijms20030488 |
0.371 |
|
| 2018 |
Woodring JL, Behera R, Sharma A, Wiedeman J, Patel G, Singh B, Guyett P, Amata E, Erath J, Roncal N, Penn E, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. Acs Medicinal Chemistry Letters. 9: 996-1001. PMID 30344906 DOI: 10.1021/Acsmedchemlett.8B00245 |
0.688 |
|
| 2018 |
Floresta G, Amata E, Barbaraci C, Gentile D, Turnaturi R, Marrazzo A, Rescifina A. A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands. Marine Drugs. 16. PMID 30322188 DOI: 10.3390/Md16100384 |
0.329 |
|
| 2018 |
Sorrenti V, Pittalà V, Romeo G, Amata E, Dichiara M, Marrazzo A, Turnaturi R, Prezzavento O, Barbagallo I, Vanella L, Rescifina A, Floresta G, Tibullo D, Di Raimondo F, Intagliata S, et al. Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. European Journal of Medicinal Chemistry. 158: 937-950. PMID 30261468 DOI: 10.1016/J.Ejmech.2018.09.048 |
0.417 |
|
| 2018 |
Greish KF, Salerno L, Al Zahrani R, Amata E, Modica MN, Romeo G, Marrazzo A, Prezzavento O, Sorrenti V, Rescifina A, Floresta G, Intagliata S, Pittalà V. Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation. Molecules (Basel, Switzerland). 23. PMID 29783634 DOI: 10.3390/Molecules23051209 |
0.479 |
|
| 2018 |
Pasquinucci L, Parenti C, Amata E, Georgoussi Z, Pallaki P, Camarda V, Calò G, Arena E, Montenegro L, Turnaturi R. Synthesis and Structure-Activity Relationships of (-)---Normetazocine-Based LP1 Derivatives. Pharmaceuticals (Basel, Switzerland). 11. PMID 29734749 DOI: 10.3390/Ph11020040 |
0.33 |
|
| 2018 |
Floresta G, Amata E, Dichiara M, Marrazzo A, Salerno L, Romeo G, Prezzavento O, Pittalà V, Rescifina A. Identification of potentially potent Heme Oxygenase-1 inhibitors through 3D-QSAR coupled to scaffold hopping analysis. Chemmedchem. PMID 29693778 DOI: 10.1002/Cmdc.201800176 |
0.465 |
|
| 2018 |
Turnaturi R, Parenti C, Prezzavento O, Marrazzo A, Pallaki P, Georgoussi Z, Amata E, Pasquinucci L. Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists. Molecules (Basel, Switzerland). 23. PMID 29547588 DOI: 10.3390/Molecules23030677 |
0.336 |
|
| 2018 |
Salerno L, Amata E, Romeo G, Marrazzo A, Prezzavento O, Floresta G, Sorrenti V, Barbagallo I, Rescifina A, Pittalà V. Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors. European Journal of Medicinal Chemistry. 148: 54-62. PMID 29454190 DOI: 10.1016/J.Ejmech.2018.02.007 |
0.454 |
|
| 2018 |
Varrica MG, Zagni C, Mineo PG, Floresta G, Monciino G, Pistarà V, Abbadessa A, Nicosia A, Castilho RM, Amata E, Rescifina A. DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma. European Journal of Medicinal Chemistry. 143: 583-590. PMID 29207341 DOI: 10.1016/J.Ejmech.2017.11.067 |
0.349 |
|
| 2018 |
Arena E, Dichiara M, Floresta G, Parenti C, Marrazzo A, Pittalà V, Amata E, Prezzavento O. Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new? Future Medicinal Chemistry. 10: 231-256. PMID 29185346 DOI: 10.4155/Fmc-2017-0164 |
0.355 |
|
| 2017 |
Amata E, Rescifina A, Prezzavento O, Arena E, Dichiara M, Pittalà V, Montilla-García Á, Punzo F, Merino P, Cobos EJ, Marrazzo A. (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties. Journal of Medicinal Chemistry. PMID 29220177 DOI: 10.1021/Acs.Jmedchem.7B01584 |
0.329 |
|
| 2017 |
Longhitano L, Castracani CC, Tibullo D, Avola R, Viola M, Russo G, Prezzavento O, Marrazzo A, Amata E, Reibaldi M, Longo A, Russo A, Parrinello NL, Volti GL. Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma. Oncotarget. 8: 91099-91111. PMID 29207628 DOI: 10.18632/Oncotarget.19556 |
0.336 |
|
| 2017 |
Amata E, Dichiara M, Arena E, Pittalà V, Pistarà V, Cardile V, Graziano ACE, Fraix A, Marrazzo A, Sortino S, Prezzavento O. Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect. Journal of Medicinal Chemistry. 60: 9531-9544. PMID 29172528 DOI: 10.1021/Acs.Jmedchem.7B00791 |
0.372 |
|
| 2017 |
Amata E, Marrazzo A, Dichiara M, Modica MN, Salerno L, Prezzavento O, Nastasi G, Rescifina A, Romeo G, Pittalà V. Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors. Data in Brief. 15: 281-299. PMID 29034293 DOI: 10.1016/J.Dib.2017.09.036 |
0.312 |
|
| 2017 |
Dichiara M, Prezzavento O, Marrazzo A, Pittalà V, Salerno L, Rescifina A, Amata E. Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents. European Journal of Medicinal Chemistry. PMID 28943196 DOI: 10.1016/J.Ejmech.2017.08.070 |
0.387 |
|
| 2017 |
Floresta G, Pistarà V, Amata E, Dichiara M, Damigella A, Marrazzo A, Prezzavento O, Punzo F, Rescifina A. Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5'-monophosphate glycosidase. Chemical Biology & Drug Design. PMID 28941159 DOI: 10.1111/Cbdd.13113 |
0.403 |
|
| 2017 |
Floresta G, Rescifina A, Marrazzo A, Dichiara M, Pistarà V, Pittalà V, Prezzavento O, Amata E. Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands. European Journal of Medicinal Chemistry. 139: 884-891. PMID 28866257 DOI: 10.1016/J.Ejmech.2017.08.053 |
0.347 |
|
| 2017 |
Salerno L, Romeo G, Modica MN, Amata E, Sorrenti V, Barbagallo I, Pittalà V. Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia. European Journal of Medicinal Chemistry. PMID 28756878 DOI: 10.1016/J.Ejmech.2017.07.031 |
0.34 |
|
| 2017 |
Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A. Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review. European Journal of Medicinal Chemistry. 138: 854-873. PMID 28738306 DOI: 10.1016/J.Ejmech.2017.07.022 |
0.4 |
|
| 2017 |
Amata E, Marrazzo A, Dichiara M, Modica MN, Salerno L, Prezzavento O, Nastasi G, Rescifina A, Romeo G, Pittalà V. Heme Oxygenase Database (HemeOxDB) and QSAR analysis of isoform 1 inhibitors. Chemmedchem. PMID 28708269 DOI: 10.1002/Cmdc.201700321 |
0.47 |
|
| 2017 |
Rescifina A, Floresta G, Marrazzo A, Parenti C, Prezzavento O, Nastasi G, Dichiara M, Amata E. Sigma-2 receptor ligands QSAR model dataset. Data in Brief. 13: 514-535. PMID 28702490 DOI: 10.1016/J.Dib.2017.06.022 |
0.302 |
|
| 2017 |
Dichiara M, Marrazzo A, Prezzavento O, Collina S, Rescifina A, Amata E. Repurposing of human kinase inhibitors in neglected protozoan diseases. Chemmedchem. PMID 28590590 DOI: 10.1002/Cmdc.201700259 |
0.492 |
|
| 2017 |
Rescifina A, Floresta G, Marrazzo A, Parenti C, Prezzavento O, Nastasi G, Dichiara M, Amata E. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 106: 94-101. PMID 28571781 DOI: 10.1016/J.Ejps.2017.05.061 |
0.4 |
|
| 2017 |
Nastasi G, Miceli C, Pittalà V, Modica MN, Prezzavento O, Romeo G, Rescifina A, Marrazzo A, Amata E. S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands. Journal of Cheminformatics. 9: 3. PMID 28123452 DOI: 10.1186/S13321-017-0191-5 |
0.319 |
|
| 2017 |
Prezzavento O, Arena E, Sánchez-Fernández C, Turnaturi R, Parenti C, Marrazzo A, Catalano R, Amata E, Pasquinucci L, Cobos EJ. (+)-and (−)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects European Journal of Medicinal Chemistry. 125: 603-610. PMID 27721146 DOI: 10.1016/J.Ejmech.2016.09.077 |
0.319 |
|
| 2016 |
Amata E, Xi H, Colmenarejo G, Gonzalez-Diaz R, Cordon-Obras C, Berlanga M, Manzano P, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Navarro M, Pollastri MP. Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing? Acs Infectious Diseases. 2: 180-186. PMID 26998514 DOI: 10.1021/Acsinfecdis.5B00136 |
0.681 |
|
| 2015 |
Devine W, Woodring JL, Swaminathan U, Amata E, Patel G, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery. Journal of Medicinal Chemistry. 58: 5522-37. PMID 26087257 DOI: 10.1021/Acs.Jmedchem.5B00515 |
0.706 |
|
| 2015 |
Amata E, Bland ND, Campbell RK, Pollastri MP. Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Tetrahedron Letters. 56: 2832-2835. PMID 25977593 DOI: 10.1016/J.Tetlet.2015.04.061 |
0.717 |
|
| 2015 |
Romeo R, Carnovale C, Giofrè SV, Chiacchio MA, Garozzo A, Amata E, Romeo G, Chiacchio U. C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation. Beilstein Journal of Organic Chemistry. 11: 328-34. PMID 25815087 DOI: 10.3762/Bjoc.11.38 |
0.413 |
|
| 2015 |
Schininà B, Martorana A, Colabufo NA, Contino M, Niso M, Perrone MG, De Guidi G, Catalfo A, Rappazzo G, Zuccarello E, Prezzavento O, Amata E, Rescifina A, Marrazzo A. 4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes Rsc Advances. 5: 47108-47113. DOI: 10.1039/C5Ra08639F |
0.331 |
|
| 2014 |
Diaz R, Luengo-Arratta SA, Seixas JD, Amata E, Devine W, Cordon-Obras C, Rojas-Barros DI, Jimenez E, Ortega F, Crouch S, Colmenarejo G, Fiandor JM, Martin JJ, Berlanga M, Gonzalez S, et al. Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign. Plos Neglected Tropical Diseases. 8: e3253. PMID 25340575 DOI: 10.1371/Journal.Pntd.0003253 |
0.727 |
|
| 2014 |
Amata E, Bland ND, Hoyt CT, Settimo L, Campbell RK, Pollastri MP. Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 4084-9. PMID 25127163 DOI: 10.1016/J.Bmcl.2014.07.063 |
0.756 |
|
| 2013 |
Andriani G, Amata E, Beatty J, Clements Z, Coffey BJ, Courtemanche G, Devine W, Erath J, Juda CE, Wawrzak Z, Wood JT, Lepesheva GI, Rodriguez A, Pollastri MP. Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth. Journal of Medicinal Chemistry. 56: 2556-67. PMID 23448316 DOI: 10.1021/Jm400012E |
0.722 |
|
| 2011 |
Mésangeau C, Amata E, Alsharif W, Seminerio MJ, Robson MJ, Matsumoto RR, Poupaert JH, McCurdy CR. Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. European Journal of Medicinal Chemistry. 46: 5154-61. PMID 21899931 DOI: 10.1016/J.Ejmech.2011.08.031 |
0.379 |
|
| 2010 |
Pasquinucci L, Prezzavento O, Marrazzo A, Amata E, Ronsisvalle S, Georgoussi Z, Fourla DD, Scoto GM, Parenti C, Aricò G, Ronsisvalle G. Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorganic & Medicinal Chemistry. 18: 4975-82. PMID 20599386 DOI: 10.1016/J.Bmc.2010.06.005 |
0.357 |
|
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