| Year |
Citation |
Score |
| 2017 |
Smith GF, Altman MD, Andresen B, Baker J, Brubaker JD, Chen H, Chen Y, Childers M, Donofrio A, Ferguson H, Fischer C, Fischmann TO, Gibeau C, Hicks A, Jin S, ... ... Northrup A, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorganic & Medicinal Chemistry Letters. PMID 28501511 DOI: 10.1016/J.Bmcl.2017.04.050 |
0.363 |
|
| 2016 |
Ellis JM, Altman MD, Cash B, Haidle AM, Kubiak RL, Maddess ML, Yan Y, Northrup AB. Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization. Acs Medicinal Chemistry Letters. 7: 1151-1155. PMID 27994755 DOI: 10.1021/Acsmedchemlett.6B00353 |
0.356 |
|
| 2016 |
Haidle AM, Childers KK, Zabierek AA, Katz JD, Jewell JP, Hou Y, Altman MD, Szewczak A, Chen D, Harsch A, Hayashi M, Warren L, Hutton M, Nuthall H, Stanton MG, ... ... Northrup A, et al. MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation. Bioorganic & Medicinal Chemistry Letters. PMID 27894874 DOI: 10.1016/J.Bmcl.2016.08.066 |
0.312 |
|
| 2016 |
Katz JD, Haidle A, Childers KK, Zabierek AA, Jewell JP, Hou Y, Altman MD, Szewczak A, Chen D, Harsch A, Hayashi M, Warren L, Hutton M, Nuthall H, Su HP, ... ... Northrup A, et al. Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27816515 DOI: 10.1016/J.Bmcl.2016.08.068 |
0.353 |
|
| 2015 |
Ellis JM, Altman MD, Bass A, Butcher JW, Byford AJ, Donofrio A, Galloway S, Haidle AM, Jewell J, Kelly N, Leccese EK, Lee S, Maddess M, Miller JR, Moy LY, ... ... Northrup AB, et al. Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors. Journal of Medicinal Chemistry. 58: 1929-39. PMID 25625541 DOI: 10.1021/Jm5018169 |
0.518 |
|
| 2014 |
Siu T, Kumarasinghe SE, Altman MD, Katcher M, Northrup A, White C, Rosenstein C, Mathur A, Xu L, Chan G, Bachman E, Bouthillette M, Dinsmore CJ, Marshall CG, Young JR. The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization. Bioorganic & Medicinal Chemistry Letters. 24: 1466-71. PMID 24582987 DOI: 10.1016/J.Bmcl.2014.02.011 |
0.395 |
|
| 2013 |
Northrup AB, Katcher MH, Altman MD, Chenard M, Daniels MH, Deshmukh SV, Falcone D, Guerin DJ, Hatch H, Li C, Lu W, Lutterbach B, Allison TJ, Patel SB, Reilly JF, et al. Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met. Journal of Medicinal Chemistry. 56: 2294-310. PMID 23379595 DOI: 10.1021/Jm301619U |
0.391 |
|
| 2012 |
Crackower MA, Moy LY, Jia Y, Yu H, Vincent S, Miller JR, Lieber G, Fernandez X, Caniga M, Gil M, Wilhelm A, Houshyar H, Northrup A, Chapman R, Abraham WM, et al. Characterization of a Novel, Potent and Selective Small Molecule Spleen Tyrosine Kinase (SYK) Inhibitor in In Vitro and In Vivo Models of Asthma. The Journal of Allergy and Clinical Immunology. 129. DOI: 10.1016/J.Jaci.2011.12.846 |
0.356 |
|
| 2011 |
Paweletz CP, Andersen JN, Pollock R, Nagashima K, Hayashi ML, Yu SU, Guo H, Bobkova EV, Xu Z, Northrup A, Blume-Jensen P, Hendrickson RC, Chi A. Identification of direct target engagement biomarkers for kinase-targeted therapeutics. Plos One. 6: e26459. PMID 22039492 DOI: 10.1371/Journal.Pone.0026459 |
0.349 |
|
| 2011 |
Ellwood-Yen K, Keilhack H, Kunii K, Dolinski B, Connor Y, Hu K, Nagashima K, O'Hare E, Erkul Y, Di Bacco A, Gargano D, Shomer NH, Angagaw M, Leccese E, Andrade P, ... ... Northrup A, et al. PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models. Cancer Research. 71: 3052-65. PMID 21493594 DOI: 10.1158/0008-5472.Can-10-2282 |
0.344 |
|
| 2011 |
Nagashima K, Shumway SD, Sathyanarayanan S, Chen AH, Dolinski B, Xu Y, Keilhack H, Nguyen T, Wiznerowicz M, Li L, Lutterbach BA, Chi A, Paweletz C, Allison T, Yan Y, ... ... Northrup A, et al. Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor. The Journal of Biological Chemistry. 286: 6433-48. PMID 21118801 DOI: 10.1074/Jbc.M110.156463 |
0.381 |
|
| 2010 |
Bobkova EV, Weber MJ, Xu Z, Zhang YL, Jung J, Blume-Jensen P, Northrup A, Kunapuli P, Andersen JN, Kariv I. Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening. The Journal of Biological Chemistry. 285: 18838-46. PMID 20385558 DOI: 10.1074/Jbc.M109.089946 |
0.386 |
|
| 2010 |
Sun D, Jung J, Rush TS, Xu Z, Weber MJ, Bobkova E, Northrup A, Kariv I. Efficient identification of novel leads by dynamic focused screening: PDK1 case stud. Combinatorial Chemistry & High Throughput Screening. 13: 16-26. PMID 20214573 DOI: 10.2174/138620710790218186 |
0.304 |
|
| 2010 |
Nagashima K, Shumway SD, Sathyanarayanan S, Chen A, Dolinski B, Xu Y, Keilhack H, Nguyen T, Wiznerowicz M, Li L, Lutterbach BA, Paweletz C, Allison T, Yan Y, Munshi SK, ... ... Northrup A, et al. Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines Journal of Biological Chemistry. DOI: 10.2210/Pdb3Nay/Pdb |
0.311 |
|
| 2010 |
Northrup A. Abstract 759: Discovery of MK-8033, a highly specific c-Met/Ron dual inhibitor for the treatment of cancer Cancer Research. 70: 759-759. DOI: 10.1158/1538-7445.Am10-759 |
0.32 |
|
| 2010 |
Andersen JN, Paweletz CP, Pollock R, Nagashima K, Northrup A, Ronald HC, Chi A. Abstract 4953: Identification of direct target engagement biomarkers for kinase drug discovery using quantitative mass spectrometry: PDK1 case study Cancer Research. 70: 4953-4953. DOI: 10.1158/1538-7445.Am10-4953 |
0.365 |
|
| 2009 |
Xu Z, Nagashima K, Sun D, Rush T, Northrup A, Andersen JN, Kariv I, Bobkova EV. Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1. Journal of Biomolecular Screening. 14: 1257-62. PMID 19822882 DOI: 10.1177/1087057109349356 |
0.379 |
|
| 2008 |
Carpenter J, Northrup AB, Chung D, Wiener JJM, Kim SG, MacMillan DWC. Total synthesis and structural revision of callipeltoside C Angewandte Chemie - International Edition. 47: 3568-3572. PMID 18381726 DOI: 10.1002/Anie.200800086 |
0.47 |
|
| 2007 |
Grimm JB, Katcher MH, Witter DJ, Northrup AB. A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis. The Journal of Organic Chemistry. 72: 8135-8. PMID 17880242 DOI: 10.1021/Jo701431J |
0.434 |
|
| 2004 |
Mangion IK, Northrup AB, MacMillan DWC. The importance of iminium geometry control in enamine catalysis: Identification of a new catalyst architecture for aldehyde-aldehyde couplings Angewandte Chemie - International Edition. 43: 6722-6724. PMID 15593153 DOI: 10.1002/Anie.200461851 |
0.326 |
|
| 2004 |
Northrup AB, MacMillan DWC. Two-step synthesis of carbohydrates by selective aldol reactions Science. 305: 1752-1755. PMID 15308765 DOI: 10.1126/Science.1101710 |
0.43 |
|
| 2004 |
Northrup AB, Mangion IK, Hettche F, MacMillan DW. Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates. Angewandte Chemie (International Ed. in English). 43: 2152-4. PMID 15083470 DOI: 10.1002/Anie.200453716 |
0.577 |
|
| 2002 |
Northrup AB, MacMillan DW. The first direct and enantioselective cross-aldol reaction of aldehydes. Journal of the American Chemical Society. 124: 6798-9. PMID 12059180 DOI: 10.1021/Ja0262378 |
0.588 |
|
| 2002 |
Northrup AB, MacMillan DW. The first general enantioselective catalytic Diels-Alder reaction with simple alpha,beta-unsaturated ketones. Journal of the American Chemical Society. 124: 2458-60. PMID 11890793 DOI: 10.1021/Ja017641U |
0.598 |
|
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