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Brock Grill, Ph.D. - Publications

Affiliations: 
2009-2012 Pharmacology University of Minnesota, Twin Cities, Minneapolis, MN 
 2012- Neuroscience The Scripps Research Institute, Scripps Florida 
Area:
Molecular mechanisms of axon termination and synapse formation
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chang C, Banerjee SL, Park SS, Zhang XL, Cotnoir-White D, Opperman KJ, Desbois M, Grill B, Kania A. Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function. Elife. 12. PMID 38289221 DOI: 10.7554/eLife.89176  0.413
2023 Amezquita J, Desbois M, Opperman KJ, Pak JS, Christensen EL, Nguyen NT, Diaz-Garcia K, Borgen MA, Grill B. Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hub. Biorxiv : the Preprint Server For Biology. PMID 38014183 DOI: 10.1101/2023.11.15.566604  0.804
2023 Chang C, Banerjee SL, Park SS, Zhang X, Cotnoir-White D, Desbois M, Grill B, Kania A. Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function. Biorxiv : the Preprint Server For Biology. PMID 37693478 DOI: 10.1101/2023.06.12.544638  0.411
2023 Desbois M, Pak JS, Opperman KJ, Giles AC, Grill B. Optimized protocol for in vivo affinity purification proteomics and biochemistry using C. elegans. Star Protocols. 4: 102262. PMID 37294631 DOI: 10.1016/j.xpro.2023.102262  0.522
2022 AlAbdi L, Desbois M, Rusnac DV, Sulaiman RA, Rosenfeld JA, Lalani S, Murdock DR, Burrage LC, Billie Au PY, Towner S, Wilson WG, Wong L, Brunet T, Strobl-Wildemann G, Burton JE, ... ... Grill B, et al. Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects. Brain : a Journal of Neurology. PMID 36200388 DOI: 10.1093/brain/awac364  0.627
2022 Maza N, Wang D, Kowalski C, Stoveken HM, Dao M, Sial OK, Giles AC, Grill B, Martemyanov KA. Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking. Nature Neuroscience. PMID 35982154 DOI: 10.1038/s41593-022-01135-0  0.489
2022 Desbois M, Opperman KJ, Amezquita J, Gaglio G, Crawley O, Grill B. Ubiquitin ligase activity inhibits Cdk5 to control axon termination. Plos Genetics. 18: e1010152. PMID 35421092 DOI: 10.1371/journal.pgen.1010152  0.461
2021 Suthakaran N, Wiggins J, Giles A, Opperman KJ, Grill B, Dawson-Scully K. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans. Plos One. 16: e0260072. PMID 34797853 DOI: 10.1371/journal.pone.0260072  0.581
2021 Wang D, Dao M, Muntean BS, Giles AC, Martemyanov KA, Grill B. Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction. Human Molecular Genetics. PMID 34508586 DOI: 10.1093/hmg/ddab235  0.522
2021 Crawley O, Grill B. Autophagy in axonal and presynaptic development. Current Opinion in Neurobiology. 69: 139-148. PMID 33940492 DOI: 10.1016/j.conb.2021.03.011  0.435
2021 Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA. Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Reports. 34: 108718. PMID 33535037 DOI: 10.1016/j.celrep.2021.108718  0.307
2020 Stoveken HM, Zucca S, Masuho I, Grill B, Martemyanov KA. The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects. The Journal of Biological Chemistry. PMID 32576659 DOI: 10.1074/Jbc.Ac120.014770  0.404
2020 Giles AC, Grill B. Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease. Neural Development. 15: 6. PMID 32336296 DOI: 10.1186/S13064-020-00143-9  0.673
2020 Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA. Using C. elegans Genetics to Identify Regulators of μ‐Opioid Receptor Signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04078  0.548
2019 Crawley O, Opperman KJ, Desbois M, Adrados I, Borgen MA, Giles AC, Duckett DR, Grill B. Autophagy is inhibited by ubiquitin ligase activity in the nervous system. Nature Communications. 10: 5017. PMID 31676756 DOI: 10.1038/S41467-019-12804-3  0.826
2019 Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA. Genetic behavioral screen identifies an orphan anti-opioid system. Science (New York, N.Y.). PMID 31416932 DOI: 10.1126/Science.Aau2078  0.547
2019 Giles AC, Desbois M, Opperman KJ, Tavora R, Maroni MJ, Grill B. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1regulates GABA neuron function. The Journal of Biological Chemistry. PMID 30858176 DOI: 10.1074/Jbc.Ra119.007406  0.661
2019 Borgen MA, Giles AC, Wang D, Grill B. Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub. Elife. 8. PMID 30652969 DOI: 10.7554/Elife.44040  0.806
2019 Borgen MA, Giles AC, Wang D, Grill B. Author response: Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub Elife. DOI: 10.7554/Elife.44040.017  0.616
2018 Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B. PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. The Journal of Biological Chemistry. PMID 29997255 DOI: 10.1074/Jbc.Ra118.002176  0.667
2017 Crawley O, Giles AC, Desbois M, Kashyap S, Birnbaum R, Grill B. A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. Plos Genetics. 13: e1007095. PMID 29228003 DOI: 10.1371/Journal.Pgen.1007095  0.724
2017 Borgen MA, Wang D, Grill B. RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability. Development (Cambridge, England). PMID 29084805 DOI: 10.1242/Dev.154187  0.799
2017 Opperman KJ, Mulcahy B, Giles AC, Risley MG, Birnbaum RL, Tulgren ED, Dawson-Scully K, Zhen M, Grill B. The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development. Cell Reports. 19: 822-835. PMID 28445732 DOI: 10.1016/J.Celrep.2017.04.003  0.804
2016 Baker ST, Grill B. Defining minimal binding regions in Regulator of Presynaptic Morphology 1 (RPM-1) using C. elegans neurons reveals differential signaling complexes. The Journal of Biological Chemistry. PMID 27979965 DOI: 10.1074/Jbc.M116.748004  0.625
2016 Risley MG, Kelly SP, Jia K, Grill B, Dawson-Scully K. Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs. Plos One. 11: e0163786. PMID 27668426 DOI: 10.1371/Journal.Pone.0163786  0.311
2016 Grill B, Murphey RK, Borgen MA. The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration. Neural Development. 11: 8. PMID 27008623 DOI: 10.1186/S13064-016-0063-0  0.83
2015 Giles AC, Opperman KJ, Rankin CH, Grill B. Developmental Function of the PHR Protein RPM-1 Is Required for Learning in Caenorhabditis elegans. G3 (Bethesda, Md.). PMID 26464359 DOI: 10.1534/G3.115.021410  0.714
2015 Baker ST, Turgeon SM, Tulgren ED, Wigant J, Rahimi O, Opperman KJ, Grill B. Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway. Genetics. 199: 151-6. PMID 25339611 DOI: 10.1534/Genetics.114.170589  0.805
2014 Sharma J, Baker ST, Turgeon SM, Gurney AM, Opperman KJ, Grill B. Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex. The Journal of Biological Chemistry. 289: 34654-66. PMID 25326385 DOI: 10.1074/Jbc.M114.614065  0.679
2014 Tulgren ED, Turgeon SM, Opperman KJ, Grill B. The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin. Plos Genetics. 10: e1004481. PMID 25010424 DOI: 10.1371/Journal.Pgen.1004481  0.841
2014 Opperman KJ, Grill B. RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons. Neural Development. 9: 10. PMID 24885325 DOI: 10.1186/1749-8104-9-10  0.589
2014 Baker ST, Opperman KJ, Tulgren ED, Turgeon SM, Bienvenut W, Grill B. RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development. Plos Genetics. 10: e1004297. PMID 24810406 DOI: 10.1371/Journal.Pgen.1004297  0.829
2012 Grill B, Chen L, Tulgren ED, Baker ST, Bienvenut W, Anderson M, Quadroni M, Jin Y, Garner CC. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2628-36. PMID 22357847 DOI: 10.1523/Jneurosci.2901-11.2012  0.8
2011 Tulgren ED, Baker ST, Rapp L, Gurney AM, Grill B. PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans. Genetics. 189: 1297-307. PMID 21968191 DOI: 10.1534/Genetics.111.134791  0.831
2008 Margeta MA, Shen K, Grill B. Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans. Current Opinion in Neurobiology. 18: 69-76. PMID 18538560 DOI: 10.1016/J.Conb.2008.04.003  0.53
2008 Abrams B, Grill B, Huang X, Jin Y. Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 630-9. PMID 18224716 DOI: 10.1002/Dvdy.21446  0.819
2007 Grill B, Bienvenut WV, Brown HM, Ackley BD, Quadroni M, Jin Y. C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1. Neuron. 55: 587-601. PMID 17698012 DOI: 10.1016/J.Neuron.2007.07.009  0.844
2006 Dai Y, Taru H, Deken SL, Grill B, Ackley B, Nonet ML, Jin Y. SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. Nature Neuroscience. 9: 1479-87. PMID 17115037 DOI: 10.1038/Nn1808  0.794
2005 Nakata K, Abrams B, Grill B, Goncharov A, Huang X, Chisholm AD, Jin Y. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell. 120: 407-20. PMID 15707898 DOI: 10.1016/J.Cell.2004.12.017  0.808
2004 Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW. Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins. Journal of Immunology (Baltimore, Md. : 1950). 172: 2389-400. PMID 14764709 DOI: 10.4049/Jimmunol.172.4.2389  0.603
2002 Grill B, Schrader JW. Activation of Rac-1, Rac-2, and Cdc42 by hemopoietic growth factors or cross-linking of the B-lymphocyte receptor for antigen. Blood. 100: 3183-92. PMID 12384416 DOI: 10.1182/Blood-2002-01-0154  0.524
2002 Schrader JW, Schallhorn A, Grill B, Guo X. Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells. Molecular Immunology. 38: 1181-6. PMID 12217381 DOI: 10.1016/S0161-5890(02)00060-3  0.556
2002 Leslie DM, Grill B, Rout MP, Wozniak RW, Aitchison JD. Kap121p-mediated nuclear import is required for mating and cellular differentiation in yeast. Molecular and Cellular Biology. 22: 2544-55. PMID 11909949 DOI: 10.1128/Mcb.22.8.2544-2555.2002  0.387
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