Brenda Jean Gehrke - Related publications

Affiliations: 
2004 University of Kentucky, Lexington, KY 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Miller L, Hébert CD, Grimes SD, Toomey JS, Oh JY, Rose JJ, Patel RP. Safety and toxicology assessment of sodium nitrite administered by intramuscular injection. Toxicology and Applied Pharmacology. 115702. PMID 34464673 DOI: 10.1016/j.taap.2021.115702   
2021 Won H, Jeong DH, Shin HS, Lee JH, Lee JP, Yang JY, Jung K, Jeong J, Oh JH. Toxicological Assessment of Bromochlorophene: Single and Repeated-Dose 28-Day Oral Toxicity, Genotoxicity, and Dermal Application in Sprague-Dawley Rats. Frontiers in Pharmacology. 12: 690141. PMID 34335256 DOI: 10.3389/fphar.2021.690141   
2021 Zhao Y, Chen S, Huai X, Yu Z, Qi Y, Qing J, Yu W, Su D. Efficiency and Safety of the Selective Relaxant Binding Agent Adamgammadex Sodium for Reversing Rocuronium-Induced Deep Neuromuscular Block: A Single-Center, Open-Label, Dose-Finding, and Phase IIa Study. Frontiers in Medicine. 8: 697395. PMID 34513870 DOI: 10.3389/fmed.2021.697395   
2021 Varshneya NB, Walentiny DM, Moisa LT, Walker TD, Akinfiresoye LR, Beardsley PM. Fentanyl-related substances elicit antinociception and hyperlocomotion in mice via opioid receptors. Pharmacology, Biochemistry, and Behavior. 173242. PMID 34302853 DOI: 10.1016/j.pbb.2021.173242   
2021 Park SH, Lim JO, Kim WI, Park SW, Lee SJ, Shin IS, Moon C, Kim JH, Heo JD, Kim JC. Subchronic Toxicity Evaluation of Aluminum Oxide Nanoparticles in Rats Following 28-Day Repeated Oral Administration. Biological Trace Element Research. PMID 34535882 DOI: 10.1007/s12011-021-02926-5   
2021 Danielsson K, Stomberg R, Adermark L, Ericson M, Söderpalm B. Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum. Translational Psychiatry. 11: 472. PMID 34518523 DOI: 10.1038/s41398-021-01589-z   
2021 Paul AK, Gueven N, Dietis N. Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats. Molecules (Basel, Switzerland). 26. PMID 34299631 DOI: 10.3390/molecules26144355   
2021 López-Sanromán FJ, Freilich GM, Gomez-Cisneros D, Varela M, Santiago I, Manso-Díaz G. Accelerometric Evaluation of the Locomotor Pattern After Administration of Morphine in Conscious Healthy Horses. Journal of Equine Veterinary Science. 104: 103701. PMID 34416984 DOI: 10.1016/j.jevs.2021.103701   
2021 Ramos KA, James IE, Skobieranda F, Soergel DG, Ruff D, Fossler MJ. Two-Part Phase 1 Multiple-Ascending-Dose Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of TRV734 in Healthy Adults. Clinical Pharmacology in Drug Development. PMID 34480428 DOI: 10.1002/cpdd.1016   
2021 Abbasloo E, Abdollahi F, Saberi A, Esmaeili-Mahani S, Kaeidi A, Akhlaghinasab F, Sheibani V, Thomas TC, Kobeissy FH, Oryan S. Involvement of T-type calcium channels in the mechanism of low dose morphine-induced hyperalgesia in adult male rats. Neuropeptides. 90: 102185. PMID 34419803 DOI: 10.1016/j.npep.2021.102185   
2021 Maliyakkal N, Saleem U, Anwar F, Shah MA, Ahmad B, Umer F, Almoyad MAA, Parambi DGT, Beeran AA, Nath LR, Aleya L, Mathew B. Ameliorative effect of ethoxylated chalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson's diseases. Environmental Science and Pollution Research International. PMID 34476688 DOI: 10.1007/s11356-021-15955-3   
2021 Yan L, Gao F, Shi W, Geng B, Zhang J, Mao J, Tian Y, Ren L, Dai X, Chen J, Zhu J, Zhang X. A Two-Generation Reproductive Toxicity Study of Lanthanum Nitrate in SD Rats. Biological Trace Element Research. PMID 34347232 DOI: 10.1007/s12011-021-02841-9   
2021 Boorman DC, Keay KA. Escalating morphine dosage fails to elicit conditioned analgesia in a preclinical chronic neuropathic pain model. Behavioural Pharmacology. PMID 34320522 DOI: 10.1097/FBP.0000000000000642   
2021 Port A, Shaw JV, Klopp-Schulze L, Bytyqi A, Vetter C, Hussey E, Mammasse N, Ona V, Bachmann A, Strugala D, Reh C, Goteti K. Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8. Pharmacology Research & Perspectives. 9: e00842. PMID 34414672 DOI: 10.1002/prp2.842   
2021 Sabe M, Zhao N, Crippa A, Kaiser S. Antipsychotics for negative and positive symptoms of schizophrenia: dose-response meta-analysis of randomized controlled acute phase trials. Npj Schizophrenia. 7: 43. PMID 34518532 DOI: 10.1038/s41537-021-00171-2   
2021 Fukaya Y, Kimura T, Yoshimura K, Umemura K, Kawamoto H. A Dose-Confirmation Phase 1 Study to Evaluate the Safety and Pharmacology of Glucarpidase in Healthy Volunteers. Clinical Pharmacology in Drug Development. PMID 34435467 DOI: 10.1002/cpdd.1010   
2021 Kosloski MP, Kalliolias GD, Xu CR, Harel S, Lai CH, Zheng W, Davis JD, Kamal MA. Pharmacokinetics and Pharmacodynamics of Itepekimab in Healthy Adults and Patients With Asthma: Phase I First-in-Human and First-in-Patient Trials. Clinical and Translational Science. PMID 34523807 DOI: 10.1111/cts.13157   
2021 Matthews RP, Ankrom W, Friedman E, Jackson Rudd D, Liu Y, Mogg R, Panebianco D, De Lepeleire I, Petkova M, Grobler JA, Stoch SA, Iwamoto M. Safety, tolerability, and pharmacokinetics of single- and multiple-dose administration of islatravir (MK-8591) in adults without HIV. Clinical and Translational Science. PMID 34463432 DOI: 10.1111/cts.13048   
2021 Botz-Zapp CA, Foster SL, Pulley DM, Hempel B, Bi GH, Xi ZX, Newman AH, Weinshenker D, Manvich DF. Effects of the selective dopamine D receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice. Behavioural Brain Research. 113506. PMID 34352292 DOI: 10.1016/j.bbr.2021.113506   
2021 Bruss J, Lister T, Gupta VK, Stone E, Morelli L, Lei Y, Melnick D. Single- and Multiple-Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative, SPR206. Antimicrobial Agents and Chemotherapy. AAC0073921. PMID 34339267 DOI: 10.1128/AAC.00739-21   
2021 Madden JT, Reyna NC, Goranson EV, Gonzalez TA, Zavala AR, Pentkowski NS. Blocking serotonin 2A (5-HT) receptors attenuates the acquisition of methamphetamine-induced conditioned place preference in adult female rats. Behavioural Brain Research. 415: 113521. PMID 34391796 DOI: 10.1016/j.bbr.2021.113521   
2021 Salemi LA, Sahlstrom AL, Lim SY, Johnson PN, Dannaway D, Miller JL. Evaluation of the Use of Caffeine Citrate Maintenance Doses >5 mg/kg/day in Preterm Neonates for Apnea of Prematurity. The Journal of Pediatric Pharmacology and Therapeutics : Jppt : the Official Journal of Ppag. 26: 608-614. PMID 34421411 DOI: 10.5863/1551-6776-26.6.608   
2021 Li X, Gao L, Liu J, Zhang H, Chen H, Yang L, Wu M, Li C, Zhu X, Ding Y, Sun L. Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, HEC30654, in Healthy Chinese Subjects. Frontiers in Pharmacology. 12: 726536. PMID 34489712 DOI: 10.3389/fphar.2021.726536   
2021 Talley AK, Thurston A, Moore G, Gupta VK, Satterfield M, Manyak E, Stokes S, Dane A, Melnick D. First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections. Antimicrobial Agents and Chemotherapy. AAC0120821. PMID 34491803 DOI: 10.1128/AAC.01208-21   
2021 Techera Antunes FT, de Souza AH, Caminski ES, Greggio S, Venturin GT, da Costa JC, Taffarel M, Rebelo IN, Gomez MV, Correa DS, Vilanova FN, Regner AP, Dallegrave E. Neuroprotective effects of the CTK 01512-2 toxin against neurotoxicity induced by 3-nitropropionic acid in rats. Neurotoxicology. PMID 34478769 DOI: 10.1016/j.neuro.2021.08.016   
2021 Cheng PNM, Liu AM, Bessudo A, Mussai F. Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors. Investigational New Drugs. PMID 34287772 DOI: 10.1007/s10637-021-01149-8   
2021 Dehpour AR, Yousefi-Manesh H, Sheibani M, Sadeghi MA, Hemmati S, Noori T, Shirooie S. Evaluation of Anti-inflammatory and Antioxidant Effects of Sumatriptan on Carbon Tetrachloride-induced Hepatotoxicity in Rats. Drug Research. PMID 34500479 DOI: 10.1055/a-1589-5395   
2021 Sartini I, Łebkowska-Wieruszewska B, Lisowski A, Poapolathep A, Sitovs A, Giorgi M. Doxycycline pharmacokinetics in geese. Journal of Veterinary Pharmacology and Therapeutics. PMID 34318509 DOI: 10.1111/jvp.13002   
2021 Garrido-Suárez BB, Garrido G, Bellma Menéndez A, Merino N, Valdés O, Delgado-Hernández R, Granados-Soto V. Synergistic interaction between amitriptyline and paracetamol in persistent and neuropathic pain models: An isobolografic analysis. Neurochemistry International. 150: 105160. PMID 34411687 DOI: 10.1016/j.neuint.2021.105160   
2021 Ponnapakkam T, Bongay-Williams K, Beamon T, Hooks R, Cheatham D, Goyal N, Anbalagan M, Foroozesh M. Acute toxicity evaluation of a novel ceramide analog for the treatment of breast cancer. Toxicology Reports. 8: 1521-1526. PMID 34401362 DOI: 10.1016/j.toxrep.2021.07.022   
2021 Adebayo AH, Ishola TA, Yakubu OF. Acute toxicity and antimalarial studies of extract of  in animals. Toxicological Research. 37: 345-354. PMID 34295798 DOI: 10.1007/s43188-020-00070-1   
2021 McCurdy S, Duffy E, Hickman M, Halasohoris S, Zumbrun SD. Efficacy of Delafloxacin against the Biothreat Pathogen . Antimicrobial Agents and Chemotherapy. AAC0073621. PMID 34339266 DOI: 10.1128/AAC.00736-21   
2021 Murugan S, Solanki H, Purusothaman D, Bethapudi B, Ravalji M, Mundkinajeddu D. Safety Evaluation of Standardized Extract of (NR-INF-02): A 90-Day Subchronic Oral Toxicity Study in Rats. Biomed Research International. 2021: 6671853. PMID 34337042 DOI: 10.1155/2021/6671853   
2021 Barker KE, Lecznar AJ, Schumacher JM, Morris JS, Gutstein HB. Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats. Journal of Neuroscience Research. PMID 34520585 DOI: 10.1002/jnr.24944   
2021 Sarturi V, Teixeira L, Coradini G, Milech V, Hartmann H, Linhares M, Martins L, de Oliveira J, Brun M. Total intravenous anesthesia with propofol associated or not with remifentanil, ketamine, or S-ketamine for laparoscopic ovariectomy in female dogs. Topics in Companion Animal Medicine. 100575. PMID 34400382 DOI: 10.1016/j.tcam.2021.100575   
2021 Takeuchi K, Kuroda Y, Numano T, Kimura M, Hayashi S, Furukawa S. Comparison of acute inhalation toxicity of sulfuric acid by the inhalation and intratracheal instillation methods. Journal of Toxicologic Pathology. 34: 269-273. PMID 34290483 DOI: 10.1293/tox.2020-0086   
2021 Ahmadi S, Zobeiri M, Mohammadi Talvar S, Masoudi K, Khanizad A, Fotouhi S, Bradburn S. Differential expression of H19, BC1, MIAT1, and MALAT1 long non-coding RNAs within key brain reward regions after repeated morphine treatment. Behavioural Brain Research. 414: 113478. PMID 34302875 DOI: 10.1016/j.bbr.2021.113478   
2021 Jung J, Huh KY, Jin X, Ha A, Park KH, Park JS, Kim E, Lee J, Jang IJ, Lee H. A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male adults. Clinical and Translational Science. PMID 34523814 DOI: 10.1111/cts.13150   
2021 Ping L, Xu B, Zhou Q, Hong Y, Sun Q, Wang J, Zhu D. Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats. Molecules (Basel, Switzerland). 26. PMID 34299551 DOI: 10.3390/molecules26144276   
2021 Ping L, Xu B, Zhou Q, Hong Y, Sun Q, Wang J, Zhu D. Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats. Molecules (Basel, Switzerland). 26. PMID 34299551 DOI: 10.3390/molecules26144276   
2021 Bilal M, Ahmad S, Rehman T, Ghauri AO, Khalid S, Abbasi WM, Zakki SA. Anti-Hyperuricemic and Uricosuric Potential of in Oxonate-Induced Hyperuricemic Rats. Dose-Response : a Publication of International Hormesis Society. 19: 15593258211040329. PMID 34483784 DOI: 10.1177/15593258211040329   
2021 Chai LF, Hardaway JC, Heatherton KR, O'Connell KP, Lopes MC, Rabinowitz BA, Ghosh CC, Guha P, Jaroch D, Cox BF, Katz SC. Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity. Vaccines. 9. PMID 34451932 DOI: 10.3390/vaccines9080807   
2021 Wu X, Meng J, Yuan H, Zhong D, Yu J, Cao G, Liu X, Guo B, Chen Y, Li Y, Shi Y, Gordeev MF, Wu J, Zhang J. Pharmacokinetics and Disposition of Contezolid in Humans-Resolution of a Disproportionate Human Metabolite for Clinical Development. Antimicrobial Agents and Chemotherapy. AAC0040921. PMID 34398672 DOI: 10.1128/AAC.00409-21   
2021 Wang Q, Qin F, Wang H, Yang H, Liu Q, Li Z, Jiang Y, Lu S, Wang Q, Lu Z. Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice. Frontiers in Neuroscience. 15: 698967. PMID 34512242 DOI: 10.3389/fnins.2021.698967   
2021 Swann-Thomsen HE, Mendez-Gallardo V, Kollmeyer LR, Hunter K, Brumley MR. A preliminary investigation of high retinoic acid exposure during fetal development on behavioral competency and litter characteristics in newborn rats. Brain and Behavior. e2253. PMID 34473418 DOI: 10.1002/brb3.2253   
2021 Wang W, Zhang X. Antihypertensive Effect of Galegine from in Rats. Molecules (Basel, Switzerland). 26. PMID 34443434 DOI: 10.3390/molecules26164830   
2021 Tournade CM, Fink DM, Williams SR, Mans C. Effects of Tinidazole on Food Intake in Chinchillas (Chinchilla lanigera). Journal of the American Association For Laboratory Animal Science : Jaalas. PMID 34325772 DOI: 10.30802/AALAS-JAALAS-20-000141   
2021 Yu Y, He AB, Liou M, Ou C, Kozłowska A, Chen P, Huang AC. The Paradoxical Effect Hypothesis of Abused Drugs in a Rat Model of Chronic Morphine Administration. Journal of Clinical Medicine. 10. PMID 34361981 DOI: 10.3390/jcm10153197   
2021 Latif K, Khan AU, Izhar Ul Haque M, Naeem K. Bergapten Attenuates Nitroglycerin-Induced Migraine Headaches through Inhibition of Oxidative Stress and Inflammatory Mediators. Acs Chemical Neuroscience. PMID 34455773 DOI: 10.1021/acschemneuro.1c00146   
2021 Harun NH, Rasdi NA, Salleh RM, Safuan S, Ahmad WANW, Fuad WEM. Subacute Toxicity Evaluation of Methanolic Extract of in Rats. Tropical Life Sciences Research. 32: 65-81. PMID 34367515 DOI: 10.21315/tlsr2021.32.2.5