| Year |
Citation |
Score |
| 2022 |
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, ... Nichols DE, et al. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. PMID 36087581 DOI: 10.1016/j.neuron.2022.08.006 |
0.351 |
|
| 2022 |
Nichols CD, Nichols DE. Preface to the special issue "Psychedelics and Neurochemistry". Journal of Neurochemistry. PMID 35699130 DOI: 10.1111/jnc.15651 |
0.433 |
|
| 2020 |
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor. Cell. 182: 1574-1588.e19. PMID 32946782 DOI: 10.1016/J.Cell.2020.08.024 |
0.318 |
|
| 2019 |
Kuypers KP, Ng L, Erritzoe D, Knudsen GM, Nichols CD, Nichols DE, Soula A, Nutt D. Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psychopharmacology (Oxford, England). 269881119857204. PMID 31303095 DOI: 10.1177/0269881119857204 |
0.419 |
|
| 2017 |
Kyzar EJ, Nichols CD, Gainetdinov RR, Nichols DE, Kalueff AV. Psychedelic Drugs in Biomedicine. Trends in Pharmacological Sciences. PMID 28947075 DOI: 10.1016/j.tips.2017.08.003 |
0.403 |
|
| 2017 |
Brandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, Stratford A, Klein LM, McCorvy JD, Nichols DE, Halberstadt AL. Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775). Drug Testing and Analysis. PMID 28585392 DOI: 10.1002/Dta.2222 |
0.649 |
|
| 2017 |
Hoehn RD, Nichols DE, McCorvy JD, Neven H, Kais S. Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28500275 DOI: 10.1073/Pnas.1618422114 |
0.693 |
|
| 2017 |
Nichols DE. Chemistry and Structure-Activity Relationships of Psychedelics. Current Topics in Behavioral Neurosciences. PMID 28401524 DOI: 10.1007/7854_2017_475 |
0.35 |
|
| 2017 |
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 168: 377-389.e12. PMID 28129538 DOI: 10.1016/J.Cell.2016.12.033 |
0.684 |
|
| 2016 |
Nichols DE, Johnson MW, Nichols CD. Psychedelics as Medicines: An Emerging New Paradigm. Clinical Pharmacology and Therapeutics. PMID 28019026 DOI: 10.1002/cpt.557 |
0.441 |
|
| 2015 |
Nichols DE, Sassano MF, Halberstadt AL, Klein LM, Brandt SD, Elliott SP, Fiedler WJ. N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues. Acs Chemical Neuroscience. 6: 1165-75. PMID 25547199 DOI: 10.1021/Cn500292D |
0.442 |
|
| 2014 |
Martin DA, Marona-Lewicka D, Nichols DE, Nichols CD. Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. Neuropharmacology. 83: 1-8. PMID 24704148 DOI: 10.1016/j.neuropharm.2014.03.013 |
0.444 |
|
| 2013 |
Juncosa JI, Hansen M, Bonner LA, Cueva JP, Maglathlin R, McCorvy JD, Marona-Lewicka D, Lill MA, Nichols DE. Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. Acs Chemical Neuroscience. 4: 96-109. PMID 23336049 DOI: 10.1021/Cn3000668 |
0.836 |
|
| 2012 |
Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE. trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. Beilstein Journal of Organic Chemistry. 8: 1705-9. PMID 23209503 DOI: 10.3762/Bjoc.8.194 |
0.752 |
|
| 2012 |
Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE. Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. Bioorganic & Medicinal Chemistry. 20: 6366-74. PMID 23018094 DOI: 10.1016/J.Bmc.2012.08.058 |
0.806 |
|
| 2012 |
Chemel BR, Bonner LA, Watts VJ, Nichols DE. Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists. Molecular Pharmacology. 81: 729-38. PMID 22334593 DOI: 10.1124/Mol.111.077339 |
0.85 |
|
| 2012 |
McCorvy JD, Watts VJ, Nichols DE. Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease. Psychopharmacology. 222: 81-7. PMID 22222862 DOI: 10.1007/S00213-011-2625-5 |
0.7 |
|
| 2012 |
Halberstadt AL, Nichols DE, Geyer MA. Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor. Psychopharmacology. 221: 709-18. PMID 22222861 DOI: 10.1007/S00213-011-2616-6 |
0.359 |
|
| 2012 |
Cueva JP, Chemel BR, Juncosa JI, Lill MA, Watts VJ, Nichols DE. Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European Journal of Medicinal Chemistry. 48: 97-107. PMID 22204903 DOI: 10.1016/J.Ejmech.2011.11.039 |
0.84 |
|
| 2011 |
Clark AH, McCorvy JD, Watts VJ, Nichols DE. Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorganic & Medicinal Chemistry. 19: 5420-31. PMID 21862338 DOI: 10.1016/J.Bmc.2011.07.057 |
0.828 |
|
| 2011 |
McCorvy JD, Harland AA, Maglathlin R, Nichols DE. A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. Neuroscience Letters. 505: 10-3. PMID 21827831 DOI: 10.1016/J.Neulet.2011.07.036 |
0.709 |
|
| 2011 |
Marona-Lewicka D, Nichols DE. Potential serotonin 5-HT(1A) and dopamine D(4) receptor modulation of the discriminative stimulus effects of amphetamine in rats. Behavioural Pharmacology. 22: 508-15. PMID 21814134 DOI: 10.1097/FBP.0b013e328349fc31 |
0.497 |
|
| 2011 |
Cueva JP, Gallardo-Godoy A, Juncosa JI, Vidi PA, Lill MA, Watts VJ, Nichols DE. Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of Medicinal Chemistry. 54: 5508-21. PMID 21714510 DOI: 10.1021/Jm200334C |
0.813 |
|
| 2011 |
Bonner LA, Laban U, Chemel BR, Juncosa JI, Lill MA, Watts VJ, Nichols DE. Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues. Chemmedchem. 6: 1024-40. PMID 21538900 DOI: 10.1002/Cmdc.201100010 |
0.818 |
|
| 2011 |
Marona-Lewicka D, Nichols CD, Nichols DE. An animal model of schizophrenia based on chronic LSD administration: old idea, new results. Neuropharmacology. 61: 503-12. PMID 21352832 DOI: 10.1016/j.neuropharm.2011.02.006 |
0.573 |
|
| 2011 |
Clark LH, Cueva JP, McCorvy JD, Harland AA, Watts VJ, Nichols DE. C-Ring expanded analogs of doxanthrine: Conformation plays a critical role Arkivoc. 2010: 125-138. DOI: 10.3998/Ark.5550190.0011.411 |
0.85 |
|
| 2010 |
Bonner LA, Chemel BR, Watts VJ, Nichols DE. Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorganic & Medicinal Chemistry. 18: 6763-70. PMID 20709559 DOI: 10.1016/J.Bmc.2010.07.052 |
0.841 |
|
| 2010 |
Laban U, Kurrasch-Orbaugh D, Marona-Lewicka D, Nichols DE. ChemInform Abstract: A Novel Fluorinated Tryptamine with Highly Potent Serotonin 5-HT1A Receptor Agonist Properties. Cheminform. 32: no-no. DOI: 10.1002/chin.200127116 |
0.841 |
|
| 2010 |
NEGASH K, NICHOLS DE, WATTS VJ, MAILMAN RB. ChemInform Abstract: Further Definition of the D1 Dopamine Receptor Pharmacophore: Synthesis of trans-6,6a,7,8,9,13b-Hexahydro-5H-benzo(d)naphth(2,1-b) azepines as Rigid Analogues of β-Phenyldopamine. Cheminform. 28: no-no. DOI: 10.1002/chin.199741209 |
0.367 |
|
| 2010 |
VANGVERAVONG S, NICHOLS DE. ChemInform Abstract: Stereoselective Synthesis of trans-2-(Indol-3-yl)cyclopropylamines: Rigid Tryptamine Analogues. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199545041 |
0.664 |
|
| 2009 |
Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F. 4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities. Chemistry & Biodiversity. 6: 692-704. PMID 19479848 DOI: 10.1002/cbdv.200800235 |
0.542 |
|
| 2009 |
Marona-Lewicka D, Nichols DE. WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. Behavioural Pharmacology. 20: 114-8. PMID 19179855 DOI: 10.1097/FBP.0b013e3283242f1a |
0.493 |
|
| 2009 |
Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ, McCorvy JD, Chester JA, Nichols DE, Watts VJ. Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46. PMID 19028082 DOI: 10.1016/J.Euroneuro.2008.10.002 |
0.835 |
|
| 2009 |
Marona-Lewicka D, Chemel BR, Nichols DE. Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology. 203: 265-77. PMID 18604600 DOI: 10.1007/S00213-008-1238-0 |
0.828 |
|
| 2009 |
Cueva JP, Nichols DE. A novel and efficient synthesis of dihydrexidine Synthesis. 715-720. DOI: 10.1055/S-0028-1083359 |
0.746 |
|
| 2009 |
Weintraub HJR, Nichols DE. Conformational energy calculations of some amphetamine analogs using a new solvation model International Journal of Quantum Chemistry. 14: 321-343. DOI: 10.1002/QUA.560140731 |
0.315 |
|
| 2008 |
Torres-Altoro MI, White KJ, Rodríguez GJ, Nichols DE, Barker EL. Helix XI contributes to the entrance of the serotonin transporter permeation pathway. Protein Science : a Publication of the Protein Society. 17: 1761-70. PMID 18628241 DOI: 10.1110/Ps.036749.108 |
0.315 |
|
| 2008 |
Nichols DE, Nichols CD. Serotonin receptors. Chemical Reviews. 108: 1614-41. PMID 18476671 DOI: 10.1021/cr078224o |
0.602 |
|
| 2008 |
Nichols DE, Frescas SP, Chemel BR, Rehder KS, Zhong D, Lewin AH. High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand. Bioorganic & Medicinal Chemistry. 16: 6116-23. PMID 18468904 DOI: 10.1016/J.Bmc.2008.04.050 |
0.827 |
|
| 2008 |
Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A. 'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines. Bioorganic & Medicinal Chemistry. 16: 6242-51. PMID 18467103 DOI: 10.1016/J.Bmc.2008.04.030 |
0.516 |
|
| 2008 |
Walline CC, Nichols DE, Carroll FI, Barker EL. Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition. The Journal of Pharmacology and Experimental Therapeutics. 325: 791-800. PMID 18354055 DOI: 10.1124/jpet.108.136200 |
0.373 |
|
| 2008 |
Parker MA, Kurrasch DM, Nichols DE. The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorganic & Medicinal Chemistry. 16: 4661-9. PMID 18296055 DOI: 10.1016/j.bmc.2008.02.033 |
0.485 |
|
| 2007 |
Braden MR, Nichols DE. Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor. Molecular Pharmacology. 72: 1200-9. PMID 17715398 DOI: 10.1124/Mol.107.039255 |
0.818 |
|
| 2007 |
Marona-Lewicka D, Nichols DE. Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacology, Biochemistry, and Behavior. 87: 453-61. PMID 17618679 DOI: 10.1016/j.pbb.2007.06.001 |
0.504 |
|
| 2007 |
Mu Q, Johnson K, Morgan PS, Grenesko EL, Molnar CE, Anderson B, Nahas Z, Kozel FA, Kose S, Knable M, Fernandes P, Nichols DE, Mailman RB, George MS. A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia. Schizophrenia Research. 94: 332-41. PMID 17596915 DOI: 10.1016/J.Schres.2007.03.033 |
0.392 |
|
| 2007 |
George MS, Molnar CE, Grenesko EL, Anderson B, Mu Q, Johnson K, Nahas Z, Knable M, Fernandes P, Juncos J, Huang X, Nichols DE, Mailman RB. A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia. Schizophrenia Research. 93: 42-50. PMID 17467956 DOI: 10.1016/J.Schres.2007.03.011 |
0.324 |
|
| 2007 |
Selken J, Nichols DE. Alpha1-adrenergic receptors mediate the locomotor response to systemic administration of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacology, Biochemistry, and Behavior. 86: 622-30. PMID 17363047 DOI: 10.1016/j.pbb.2007.02.006 |
0.376 |
|
| 2007 |
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/Jpet.106.104463 |
0.451 |
|
| 2006 |
Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE. trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. Journal of Medicinal Chemistry. 49: 6848-57. PMID 17154515 DOI: 10.1021/Jm0604979 |
0.832 |
|
| 2006 |
Parrish JC, Nichols DE. Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. Journal of Neurochemistry. 99: 1164-75. PMID 17010161 DOI: 10.1111/J.1471-4159.2006.04173.X |
0.8 |
|
| 2006 |
White KJ, Kiser PD, Nichols DE, Barker EL. Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter. Protein Science : a Publication of the Protein Society. 15: 2411-22. PMID 17008722 DOI: 10.1110/Ps.062386106 |
0.328 |
|
| 2006 |
Braden MR, Parrish JC, Naylor JC, Nichols DE. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular Pharmacology. 70: 1956-64. PMID 17000863 DOI: 10.1124/Mol.106.028720 |
0.846 |
|
| 2006 |
McLean TH, Parrish JC, Braden MR, Marona-Lewicka D, Gallardo-Godoy A, Nichols DE. 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. Journal of Medicinal Chemistry. 49: 5794-803. PMID 16970404 DOI: 10.1021/Jm060656O |
0.856 |
|
| 2006 |
Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology. 188: 244-51. PMID 16915381 DOI: 10.1007/S00213-006-0490-4 |
0.856 |
|
| 2006 |
McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. Journal of Medicinal Chemistry. 49: 4269-74. PMID 16821786 DOI: 10.1021/Jm060272Y |
0.832 |
|
| 2006 |
Lewis MM, Huang X, Nichols DE, Mailman RB. D1 and functionally selective dopamine agonists as neuroprotective agents in Parkinson's disease. Cns & Neurological Disorders Drug Targets. 5: 345-53. PMID 16787233 DOI: 10.2174/187152706777452245 |
0.319 |
|
| 2005 |
Parrish JC, Braden MR, Gundy E, Nichols DE. Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists. Journal of Neurochemistry. 95: 1575-84. PMID 16277614 DOI: 10.1111/J.1471-4159.2005.03477.X |
0.846 |
|
| 2005 |
Ryman-Rasmussen JP, Nichols DE, Mailman RB. Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. Molecular Pharmacology. 68: 1039-48. PMID 15985612 DOI: 10.1124/mol.105.012153 |
0.571 |
|
| 2005 |
Gallardo-Godoy A, Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE. Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. Journal of Medicinal Chemistry. 48: 2407-19. PMID 15801832 DOI: 10.1021/jm0493109 |
0.376 |
|
| 2005 |
Marona-Lewicka D, Thisted RA, Nichols DE. Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Psychopharmacology. 180: 427-35. PMID 15723230 DOI: 10.1007/s00213-005-2183-9 |
0.426 |
|
| 2004 |
Hrometz SL, Brown AW, Nichols DE, Sprague JE. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neuroscience Letters. 367: 56-9. PMID 15308297 DOI: 10.1016/J.Neulet.2004.05.075 |
0.357 |
|
| 2004 |
Gay EA, Urban JD, Nichols DE, Oxford GS, Mailman RB. Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Molecular Pharmacology. 66: 97-105. PMID 15213300 DOI: 10.1124/Mol.66.1.97 |
0.482 |
|
| 2004 |
Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE. 8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms. Bioorganic & Medicinal Chemistry. 12: 1403-12. PMID 15018913 DOI: 10.1016/J.Bmc.2004.01.008 |
0.841 |
|
| 2004 |
Nichols DE. Hallucinogens. Pharmacology & Therapeutics. 101: 131-81. PMID 14761703 DOI: 10.1016/j.pharmthera.2003.11.002 |
0.344 |
|
| 2004 |
Sit SY, Xie K, Jacutin-Porte S, Boy KM, Seanz J, Taber MT, Gulwadi AG, Korpinen CD, Burris KD, Molski TF, Ryan E, Xu C, Verdoorn T, Johnson G, Nichols DE, et al. Synthesis and SAR exploration of dinapsoline analogues. Bioorganic & Medicinal Chemistry. 12: 715-34. PMID 14759732 DOI: 10.1016/j.bmc.2003.11.015 |
0.528 |
|
| 2004 |
Marona-Lewicka D, Nichols DE. Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats. Psychopharmacology. 172: 415-21. PMID 14647959 DOI: 10.1007/s00213-003-1677-6 |
0.552 |
|
| 2004 |
Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL. Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 308: 679-87. PMID 14593087 DOI: 10.1124/Jpet.103.057836 |
0.413 |
|
| 2004 |
Nichols DE, Lewis MM. Mechanisms and issues relating to the use of D1-like dopamine receptor agonists for age-related illnesses: Parkinson's disease and memory and cognition Medicinal Chemistry Research. 13: 105-114. DOI: 10.1007/s00044-004-0016-8 |
0.38 |
|
| 2003 |
Kurrasch-Orbaugh DM, Parrish JC, Watts VJ, Nichols DE. A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. Journal of Neurochemistry. 86: 980-91. PMID 12887695 DOI: 10.1046/J.1471-4159.2003.01921.X |
0.824 |
|
| 2003 |
Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. Journal of Medicinal Chemistry. 46: 3526-35. PMID 12877591 DOI: 10.1021/Jm030064V |
0.838 |
|
| 2003 |
Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL. Distinct recognition of substrates by the human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 306: 338-46. PMID 12682215 DOI: 10.1124/Jpet.103.048751 |
0.364 |
|
| 2003 |
Qandil AM, Lewis MM, Jassen A, Leonard SK, Mailman RB, Nichols DE. Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands. Bioorganic & Medicinal Chemistry. 11: 1451-64. PMID 12628671 DOI: 10.1016/S0968-0896(02)00561-8 |
0.483 |
|
| 2003 |
Kurrasch-Orbaugh DM, Watts VJ, Barker EL, Nichols DE. Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. The Journal of Pharmacology and Experimental Therapeutics. 304: 229-37. PMID 12490596 DOI: 10.1124/Jpet.102.042184 |
0.837 |
|
| 2002 |
Chambers JJ, Nichols DE. A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor. Journal of Computer-Aided Molecular Design. 16: 511-20. PMID 12510883 DOI: 10.1023/A:1021275430021 |
0.692 |
|
| 2002 |
Kanthasamy A, Sprague JE, Shotwell JR, Nichols DE. Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience. 114: 917-24. PMID 12379247 DOI: 10.1016/S0306-4522(02)00368-8 |
0.608 |
|
| 2002 |
Marona-Lewicka D, Kurrasch-Orbaugh DM, Selken JR, Cumbay MG, Lisnicchia JG, Nichols DE. Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats. Psychopharmacology. 164: 93-107. PMID 12373423 DOI: 10.1007/S00213-002-1141-Z |
0.842 |
|
| 2002 |
Nichols DE, Frescas S, Marona-Lewicka D, Kurrasch-Orbaugh DM. Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD). Journal of Medicinal Chemistry. 45: 4344-9. PMID 12213075 DOI: 10.1021/Jm020153S |
0.815 |
|
| 2002 |
Falk EM, Cook VJ, Nichols DE, Sprague JE. An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacology, Biochemistry, and Behavior. 72: 617-22. PMID 12175458 DOI: 10.1016/S0091-3057(02)00728-1 |
0.359 |
|
| 2002 |
Whiteside MS, Kurrasch-Orbaugh D, Marona-Lewicka D, Nichols DE, Monte A. Substituted hexahydrobenzodipyrans as 5-HT2A/2C receptor probes. Bioorganic & Medicinal Chemistry. 10: 3301-6. PMID 12150876 DOI: 10.1016/S0968-0896(02)00209-2 |
0.836 |
|
| 2002 |
Chambers JJ, Kurrasch-Orbaugh DM, Nichols DE. Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity. Bioorganic & Medicinal Chemistry Letters. 12: 1997-9. PMID 12113827 DOI: 10.1016/S0960-894X(02)00306-2 |
0.833 |
|
| 2002 |
Kilts JD, Connery HS, Arrington EG, Lewis MM, Lawler CP, Oxford GS, O'Malley KL, Todd RD, Blake BL, Nichols DE, Mailman RB. Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. The Journal of Pharmacology and Experimental Therapeutics. 301: 1179-89. PMID 12023553 DOI: 10.1124/jpet.301.3.1179 |
0.527 |
|
| 2002 |
Mottola DM, Kilts JD, Lewis MM, Connery HS, Walker QD, Jones SR, Booth RG, Hyslop DK, Piercey M, Wightman RM, Lawler CP, Nichols DE, Mailman RB. Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. The Journal of Pharmacology and Experimental Therapeutics. 301: 1166-78. PMID 12023552 DOI: 10.1124/jpet.301.3.1166 |
0.549 |
|
| 2002 |
Sprague JE, Leifheit M, Selken J, Milks MM, Kinder DH, Nichols DE. In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol. Synapse (New York, N.Y.). 43: 118-21. PMID 11754490 DOI: 10.1002/Syn.10025 |
0.314 |
|
| 2001 |
Mailman R, Huang X, Nichols DE. Parkinson's disease and D1 dopamine receptors. Current Opinion in Investigational Drugs (London, England : 2000). 2: 1582-91. PMID 11763161 |
0.346 |
|
| 2001 |
Huang X, Lawler CP, Lewis MM, Nichols DE, Mailman RB. D1 dopamine receptors. International Review of Neurobiology. 48: 65-139. PMID 11526741 DOI: 10.1016/S0074-7742(01)48014-7 |
0.526 |
|
| 2001 |
Chambers JJ, Kurrasch-Orbaugh DM, Parker MA, Nichols DE. Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. Journal of Medicinal Chemistry. 44: 1003-10. PMID 11300881 DOI: 10.1021/Jm000491Y |
0.855 |
|
| 2001 |
Laban U, Kurrasch-Orbaugh D, Marona-Lewicka D, Nichols DE. A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties. Bioorganic & Medicinal Chemistry Letters. 11: 793-5. PMID 11277522 DOI: 10.1016/S0960-894X(01)00062-2 |
0.83 |
|
| 2001 |
Gulwadi AG, Korpinen CD, Mailman RB, Nichols DE, Sit SY, Taber MT. Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 296: 338-44. PMID 11160615 |
0.384 |
|
| 2001 |
Sattelkau T, Qandil AM, Nichols DE. An efficient synthesis of the potent dopamine D1 agonist dinapsoline by construction and selective reduction of 2′-azadimethoxybenzanthrone Synthesis. 262-266. DOI: 10.1055/S-2001-10809 |
0.454 |
|
| 2001 |
Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE. ChemInform Abstract: Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines. Cheminform. 32: no-no. DOI: 10.1002/chin.200111113 |
0.762 |
|
| 2000 |
Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 43: 4701-10. PMID 11101361 DOI: 10.1021/Jm000339W |
0.835 |
|
| 1999 |
Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE. Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain. Journal of Medicinal Chemistry. 42: 4257-63. PMID 10514296 DOI: 10.1021/Jm990325U |
0.844 |
|
| 1999 |
Hoffman B, Cho SJ, Zheng W, Wyrick S, Nichols DE, Mailman RB, Tropsha A. Quantitative structure-activity relationship modeling of dopamine D(1) antagonists using comparative molecular field analysis, genetic algorithms-partial least-squares, and K nearest neighbor methods. Journal of Medicinal Chemistry. 42: 3217-26. PMID 10464009 DOI: 10.1021/jm980415j |
0.367 |
|
| 1999 |
Scorza C, Silveira R, Nichols DE, Reyes-Parada M. Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Neuropharmacology. 38: 1055-61. PMID 10428424 DOI: 10.1016/S0028-3908(99)00023-4 |
0.395 |
|
| 1999 |
Blair JB, Marona-Lewicka D, Kanthasamy A, Lucaites VL, Nelson DL, Nichols DE. Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine. Journal of Medicinal Chemistry. 42: 1106-11. PMID 10090793 DOI: 10.1021/Jm980692Q |
0.7 |
|
| 1999 |
Doll MK, Nichols DE, Kilts JD, Prioleau C, Lawler CP, Lewis MM, Mailman RB. Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. Journal of Medicinal Chemistry. 42: 935-40. PMID 10072690 DOI: 10.1021/jm9804533 |
0.566 |
|
| 1999 |
Qandil AM, Ghosh D, Nichols DE. Alternative formal synthesis of the potent D1 dopamine agonist dihydroxy-2,3,7,11b-tetrahydro-1H-naphth[1,2,3-de]isoquinoline: Dinapsoline Journal of Organic Chemistry. 64: 1407-1409. DOI: 10.1021/jo982067z |
0.444 |
|
| 1998 |
Parker MA, Marona-Lewicka D, Lucaites VL, Nelson DL, Nichols DE. A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor. Journal of Medicinal Chemistry. 41: 5148-9. PMID 9857084 DOI: 10.1021/Jm9803525 |
0.478 |
|
| 1998 |
Vangveravong S, Kanthasamy A, Lucaites VL, Nelson DL, Nichols DE. Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives. Journal of Medicinal Chemistry. 41: 4995-5001. PMID 9836617 DOI: 10.1021/Jm980318Q |
0.836 |
|
| 1998 |
Lieberman JA, Mailman RB, Duncan G, Sikich L, Chakos M, Nichols DE, Kraus JE. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biological Psychiatry. 44: 1099-117. PMID 9836014 DOI: 10.1016/S0006-3223(98)00187-5 |
0.401 |
|
| 1998 |
Troconis M, Ma W, Nichols DE, McLaughlin J. Molecular modeling study of tubulosine and other related ipecac alkaloids. Journal of Computer-Aided Molecular Design. 12: 411-8. PMID 9834903 DOI: 10.1023/A:1008019720578 |
0.38 |
|
| 1998 |
Mailman RB, Nichols DE. Dopamine D1 receptor agonists as antiparkinson drugs. Trends in Pharmacological Sciences. 19: 255-6. PMID 9703756 DOI: 10.1016/S0165-6147(98)01219-X |
0.392 |
|
| 1998 |
Marona-Lewicka D, Nichols DE. Drug discrimination studies of the interoceptive cues produced by selective serotonin uptake inhibitors and selective serotonin releasing agents. Psychopharmacology. 138: 67-75. PMID 9694528 DOI: 10.1007/s002130050646 |
0.375 |
|
| 1998 |
Lewis MM, Watts VJ, Lawler CP, Nichols DE, Mailman RB. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. The Journal of Pharmacology and Experimental Therapeutics. 286: 345-53. PMID 9655879 |
0.47 |
|
| 1998 |
Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE. Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity. Journal of Medicinal Chemistry. 41: 2134-45. PMID 9622555 DOI: 10.1021/jm980076u |
0.564 |
|
| 1998 |
Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE. Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA). Journal of Medicinal Chemistry. 41: 1001-5. PMID 9526575 DOI: 10.1021/jm9705925 |
0.455 |
|
| 1998 |
Cozzi NV, Frescas S, Marona-Lewicka D, Huang X, Nichols DE. Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. Pharmacology, Biochemistry, and Behavior. 59: 709-15. PMID 9512076 DOI: 10.1016/S0091-3057(97)00557-1 |
0.398 |
|
| 1997 |
Marona-Lewicka D, Nichols DE. The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats. Stress (Amsterdam, Netherlands). 2: 91-100. PMID 9787258 DOI: 10.3109/10253899709014740 |
0.31 |
|
| 1997 |
Marona-Lewicka D, Nichols DE. 5-HT2A/2C receptor agonists potentiate the discriminative cue of (+)-amphetamine in the rat. Neuropharmacology. 36: 1471-5. PMID 9423936 DOI: 10.1016/S0028-3908(97)00106-8 |
0.405 |
|
| 1997 |
Monte AP, Waldman SR, Marona-Lewicka D, Wainscott DB, Nelson DL, Sanders-Bush E, Nichols DE. Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives. Journal of Medicinal Chemistry. 40: 2997-3008. PMID 9301661 DOI: 10.1021/jm970219x |
0.532 |
|
| 1997 |
Negash K, Nichols DE, Watts VJ, Mailman RB. Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine. Journal of Medicinal Chemistry. 40: 2140-7. PMID 9216832 DOI: 10.1021/Jm970157A |
0.445 |
|
| 1997 |
Smith HP, Nichols DE, Mailman RB, Lawler CP. Locomotor inhibition, yawning and vacuous chewing induced by a novel dopamine D2 post-synaptic receptor agonist. European Journal of Pharmacology. 323: 27-36. PMID 9105873 DOI: 10.1016/S0014-2999(97)00026-5 |
0.518 |
|
| 1996 |
Reyes-Parada M, Scorza C, Romero V, Silveira R, Medina JH, Andrus D, Nichols DE, Cassels BK. (+/-)-1-(2,5-Dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 354: 579-85. PMID 8938655 DOI: 10.1007/Bf00170831 |
0.461 |
|
| 1996 |
Sprague JE, Johnson MP, Schmidt CJ, Nichols DE. Studies on the mechanism of p-chloroamphetamine neurotoxicity. Biochemical Pharmacology. 52: 1271-7. PMID 8937435 DOI: 10.1016/0006-2952(96)00482-0 |
0.361 |
|
| 1996 |
Cozzi NV, Nichols DE. 5-HT2A receptor antagonists inhibit potassium-stimulated gamma-aminobutyric acid release in rat frontal cortex. European Journal of Pharmacology. 309: 25-31. PMID 8864689 DOI: 10.1016/0014-2999(96)00325-1 |
0.368 |
|
| 1996 |
Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE. Reinforcing effects of certain serotonin-releasing amphetamine derivatives. Pharmacology, Biochemistry, and Behavior. 53: 99-105. PMID 8848466 DOI: 10.1016/0091-3057(95)00205-7 |
0.331 |
|
| 1996 |
Nichols DE, Monte A, Huang X, Marona-Lewicka D. Stereoselective pharmacological effects of lysergic acid amides possessing chirality in the amide substituent. Behavioural Brain Research. 73: 117-9. PMID 8788487 DOI: 10.1016/0166-4328(96)00080-0 |
0.473 |
|
| 1996 |
Monte AP, Marona-Lewicka D, Parker MA, Wainscott DB, Nelson DL, Nichols DE. Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups. Journal of Medicinal Chemistry. 39: 2953-61. PMID 8709129 DOI: 10.1021/jm960199j |
0.53 |
|
| 1996 |
Mottola DM, Laiter S, Watts VJ, Tropsha A, Wyrick SD, Nichols DE, Mailman RB. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. Journal of Medicinal Chemistry. 39: 285-96. PMID 8568818 DOI: 10.1021/Jm9502100 |
0.567 |
|
| 1996 |
Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE. 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore. Journal of Medicinal Chemistry. 39: 549-55. PMID 8558526 DOI: 10.1021/Jm950707+ |
0.462 |
|
| 1995 |
Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE. Psychostimulant-like effects of p-fluoroamphetamine in the rat. European Journal of Pharmacology. 287: 105-13. PMID 8749023 DOI: 10.1016/0014-2999(95)00478-5 |
0.384 |
|
| 1995 |
Watts VJ, Lawler CP, Gonzales AJ, Zhou QY, Civelli O, Nichols DE, Mailman RB. Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists. Synapse (New York, N.Y.). 21: 177-87. PMID 8584979 DOI: 10.1002/syn.890210211 |
0.544 |
|
| 1995 |
Marona-Lewicka D, Nichols DE. Complex stimulus properties of LSD: a drug discrimination study with alpha 2-adrenoceptor agonists and antagonists. Psychopharmacology. 120: 384-91. PMID 8539318 DOI: 10.1007/BF02245809 |
0.429 |
|
| 1995 |
Brewster WK, Nichols DE, Watts VJ, Riggs RM, Mottola D, Mailman RB. Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. Journal of Medicinal Chemistry. 38: 318-27. PMID 7830274 DOI: 10.1021/Jm00002A013 |
0.852 |
|
| 1995 |
Heidenreich BA, Mailman RB, Nichols DE, Napier TC. Partial and full dopamine D1 agonists produce comparable increases in ventral pallidal neuronal activity: contribution of endogenous dopamine. The Journal of Pharmacology and Experimental Therapeutics. 273: 516-25. PMID 7714807 |
0.331 |
|
| 1995 |
Monte AP, Marona-Lewicka D, Kanthasamy A, Sanders-Bush E, Nichols DE. Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. Journal of Medicinal Chemistry. 38: 958-66. PMID 7699712 DOI: 10.1021/Jm00006A015 |
0.638 |
|
| 1995 |
Oberlender R, Ramachandran PV, Johnson MP, Huang X, Nichols DE. Effect of a chiral 4-alkyl substituent in hallucinogenic amphetamines. Journal of Medicinal Chemistry. 38: 3593-601. PMID 7658446 |
0.421 |
|
| 1995 |
Knoerzer TA, Watts VJ, Nichols DE, Mailman RB. Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. Journal of Medicinal Chemistry. 38: 3062-70. PMID 7636869 DOI: 10.1021/Jm00016A009 |
0.432 |
|
| 1995 |
Snyder SE, Aviles-Garay FA, Chakraborti R, Nichols DE, Watts VJ, Mailman RB. Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of beta-phenyldopamine. Journal of Medicinal Chemistry. 38: 2395-409. PMID 7608904 DOI: 10.1021/Jm00013A015 |
0.519 |
|
| 1995 |
Watts VJ, Lawler CP, Fox DR, Neve KA, Nichols DE, Mailman RB. LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors. Psychopharmacology. 118: 401-9. PMID 7568626 DOI: 10.1007/Bf02245940 |
0.579 |
|
| 1995 |
Gilmore JH, Watts VJ, Lawler CP, Noll EP, Nichols DE, Mailman RB. "Full" dopamine D1 agonists in human caudate: biochemical properties and therapeutic implications. Neuropharmacology. 34: 481-8. PMID 7566481 DOI: 10.1016/0028-3908(95)00014-W |
0.541 |
|
| 1995 |
Sprague JE, Nichols DE. Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. Psychopharmacology. 118: 357-9. PMID 7542394 DOI: 10.1007/Bf02245967 |
0.38 |
|
| 1995 |
Vangveravong S, Nichols DE. Stereoselective synthesis of trans-2-(indol-3-yl)cyclopropylamines: Rigid tryptamine analogues Journal of Organic Chemistry. 60: 3409-3413. DOI: 10.1021/Jo00116A028 |
0.681 |
|
| 1994 |
Huang X, Marona-Lewicka D, Pfaff RC, Nichols DE. Drug discrimination and receptor binding studies of N-isopropyl lysergamide derivatives. Pharmacology, Biochemistry, and Behavior. 47: 667-73. PMID 8208787 DOI: 10.1016/0091-3057(94)90172-4 |
0.303 |
|
| 1994 |
Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist. Journal of Medicinal Chemistry. 37: 4346-51. PMID 7996545 DOI: 10.1021/Jm00051A011 |
0.543 |
|
| 1994 |
Minor DL, Wyrick SD, Charifson PS, Watts VJ, Nichols DE, Mailman RB. Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists. Journal of Medicinal Chemistry. 37: 4317-28. PMID 7996543 DOI: 10.1021/Jm00051A008 |
0.527 |
|
| 1994 |
Sprague JE, Huang X, Kanthasamy A, Nichols DE. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan. Life Sciences. 55: 1193-8. PMID 7934616 DOI: 10.1016/0024-3205(94)00658-X |
0.613 |
|
| 1994 |
Marona-Lewicka D, Nichols DE. Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan. European Journal of Pharmacology. 258: 1-13. PMID 7925587 DOI: 10.1016/0014-2999(94)90051-5 |
0.428 |
|
| 1994 |
Knoerzer TA, Nichols DE, Brewster WK, Watts VJ, Mottola D, Mailman RB. Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. Journal of Medicinal Chemistry. 37: 2453-60. PMID 7914538 DOI: 10.1021/Jm00041A025 |
0.853 |
|
| 1994 |
Lewis MH, Gariépy JL, Gendreau P, Nichols DE, Mailman RB. Social reactivity and D1 dopamine receptors: studies in mice selectively bred for high and low levels of aggression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 10: 115-22. PMID 7912934 DOI: 10.1038/npp.1994.13 |
0.371 |
|
| 1994 |
Nash JF, Roth BL, Brodkin JD, Nichols DE, Gudelsky GA. Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphatidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors. Neuroscience Letters. 177: 111-5. PMID 7824160 DOI: 10.1016/0304-3940(94)90057-4 |
0.49 |
|
| 1993 |
Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE. Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine. Journal of Medicinal Chemistry. 36: 3700-6. PMID 8246240 |
0.306 |
|
| 1993 |
Watts VJ, Lawler CP, Knoerzer T, Mayleben MA, Neve KA, Nichols DE, Mailman RB. Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands. European Journal of Pharmacology. 239: 271-3. PMID 8223910 DOI: 10.1016/0014-2999(93)91012-C |
0.55 |
|
| 1993 |
Huang X, Nichols DE. 5-HT2 receptor-mediated potentiation of dopamine synthesis and central serotonergic deficits. European Journal of Pharmacology. 238: 291-6. PMID 8104811 DOI: 10.1016/0014-2999(93)90859-G |
0.385 |
|
| 1993 |
Kohli JD, Horn PT, Glock D, Brewster WK, Nichols DE. Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. European Journal of Pharmacology. 235: 31-5. PMID 8100195 DOI: 10.1016/0014-2999(93)90816-Z |
0.847 |
|
| 1993 |
Watts VJ, Lawler CP, Gilmore JH, Southerland SB, Nichols DE, Mailman RB. Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents. European Journal of Pharmacology. 242: 165-72. PMID 7902811 DOI: 10.1016/0014-2999(93)90076-T |
0.504 |
|
| 1993 |
Callaway CW, Wing LL, Nichols DE, Geyer MA. Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release. Psychopharmacology. 111: 169-78. PMID 7870948 DOI: 10.1007/BF02245519 |
0.401 |
|
| 1992 |
Oberlender R, Pfaff RC, Johnson MP, Huang XM, Nichols DE. Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane. Journal of Medicinal Chemistry. 35: 203-11. PMID 1732537 DOI: 10.1021/Jm00080A001 |
0.478 |
|
| 1992 |
Tomaszewski Z, Johnson MP, Huang X, Nichols DE. Benzofuran bioisosteres of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 35: 2061-4. PMID 1534585 |
0.44 |
|
| 1992 |
Mottola DM, Brewster WK, Cook LL, Nichols DE, Mailman RB. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. The Journal of Pharmacology and Experimental Therapeutics. 262: 383-93. PMID 1352553 |
0.419 |
|
| 1991 |
Oberlender R, Nichols DE. Structural variation and (+)-amphetamine-like discriminative stimulus properties. Pharmacology, Biochemistry, and Behavior. 38: 581-6. PMID 2068194 DOI: 10.1016/0091-3057(91)90017-V |
0.316 |
|
| 1991 |
Nichols DE, Snyder SE, Oberlender R, Johnson MP, Huang XM. 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines. Journal of Medicinal Chemistry. 34: 276-81. PMID 1992127 DOI: 10.1021/JM00105A043 |
0.395 |
|
| 1991 |
Callaway CW, Johnson MP, Gold LH, Nichols DE, Geyer MA. Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists. Psychopharmacology. 104: 293-301. PMID 1924637 DOI: 10.1007/BF02246026 |
0.401 |
|
| 1991 |
Nichols DE, Johnson MP, Oberlender R. 5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine. Pharmacology, Biochemistry, and Behavior. 38: 135-9. PMID 1826785 DOI: 10.1016/0091-3057(91)90601-W |
0.408 |
|
| 1991 |
Johnson MP, Huang XM, Nichols DE. Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue. Pharmacology, Biochemistry, and Behavior. 40: 915-22. PMID 1726189 DOI: 10.1016/0091-3057(91)90106-C |
0.377 |
|
| 1991 |
Nash JF, Nichols DE. Microdialysis studies on 3,4-methylenedioxyamphetamine and structurally related analogues. European Journal of Pharmacology. 200: 53-8. PMID 1722755 DOI: 10.1016/0014-2999(91)90664-C |
0.388 |
|
| 1991 |
Huang XM, Johnson MP, Nichols DE. Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase). European Journal of Pharmacology. 200: 187-90. PMID 1722753 DOI: 10.1016/0014-2999(91)90686-K |
0.344 |
|
| 1991 |
Johnson MP, Nichols DE. Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in rats. Neuropharmacology. 30: 819-22. PMID 1717873 DOI: 10.1016/0028-3908(91)90192-E |
0.397 |
|
| 1991 |
Lovenberg TW, Roth RH, Nichols DE, Mailman RB. D1 dopamine receptors of NS20Y neuroblastoma cells are functionally similar to rat striatal D1 receptors. Journal of Neurochemistry. 57: 1563-9. PMID 1717649 DOI: 10.1111/J.1471-4159.1991.Tb06352.X |
0.413 |
|
| 1991 |
Johnson MP, Conarty PF, Nichols DE. [3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues. European Journal of Pharmacology. 200: 9-16. PMID 1685125 DOI: 10.1016/0014-2999(91)90659-E |
0.436 |
|
| 1991 |
Darney KJ, Lewis MH, Brewster WK, Nichols DE, Mailman RB. Behavioral effects in the rat of dihydrexidine, a high-potency, full-efficacy D1 dopamine receptor agonist. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 5: 187-95. PMID 1684499 |
0.366 |
|
| 1991 |
Elsworth JD, Lawrence MS, Roth RH, Taylor JR, Mailman RB, Nichols DE, Lewis MH, Redmond DE. D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey. The Journal of Pharmacology and Experimental Therapeutics. 259: 595-600. PMID 1682479 |
0.349 |
|
| 1991 |
Lovenberg TW, Nichols DE, Nestler EJ, Roth RH, Mailman RB. Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors. Brain Research. 556: 101-7. PMID 1682005 DOI: 10.1016/0006-8993(91)90552-7 |
0.393 |
|
| 1991 |
Taylor JR, Lawrence MS, Redmond DE, Elsworth JD, Roth RH, Nichols DE, Mailman RB. Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. European Journal of Pharmacology. 199: 389-91. PMID 1680717 DOI: 10.1016/0014-2999(91)90508-N |
0.401 |
|
| 1991 |
Steele TD, Brewster WK, Johnson MP, Nichols DE, Yim GK. Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA. Pharmacology, Biochemistry, and Behavior. 38: 345-51. PMID 1676172 DOI: 10.1016/0091-3057(91)90289-E |
0.771 |
|
| 1991 |
Persons PE, Mayer JP, Nichols DE, Cassady JM, Smalstig EB, Clemens JA. Preliminary evaluation of 4-(2-N,N-dialkylaminoethyl)indoles as potential dopamine agonists European Journal of Medicinal Chemistry. 26: 473-475. DOI: 10.1016/0223-5234(91)90110-9 |
0.357 |
|
| 1990 |
Johnson MP, Mathis CA, Shulgin AT, Hoffman AJ, Nichols DE. [125I]-2-(2,5-dimethoxy-4-iodophenyl)aminoethane ([125I]-2C-I) as a label for the 5-HT2 receptor in rat frontal cortex. Pharmacology, Biochemistry, and Behavior. 35: 211-7. PMID 2315361 DOI: 10.1016/0091-3057(90)90228-A |
0.441 |
|
| 1990 |
Johnson MP, Nichols DE. Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine. Pharmacology, Biochemistry, and Behavior. 36: 105-9. PMID 2140899 DOI: 10.1016/0091-3057(90)90133-3 |
0.391 |
|
| 1990 |
Johnson MP, Huang XM, Oberlender R, Nash JF, Nichols DE. Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. European Journal of Pharmacology. 191: 1-10. PMID 1982656 DOI: 10.1016/0014-2999(90)94090-K |
0.386 |
|
| 1990 |
Nichols DE, Oberlender R. Structure-activity relationships of MDMA and related compounds: a new class of psychoactive drugs? Annals of the New York Academy of Sciences. 600: 613-23; discussion 6. PMID 1979214 DOI: 10.1111/J.1749-6632.1990.Tb16914.X |
0.319 |
|
| 1990 |
Brewster WK, Nichols DE, Riggs RM, Mottola DM, Lovenberg TW, Lewis MH, Mailman RB. trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. Journal of Medicinal Chemistry. 33: 1756-64. PMID 1971308 DOI: 10.1021/Jm00168A034 |
0.854 |
|
| 1990 |
Nichols DE, Brewster WK, Johnson MP, Oberlender R, Riggs RM. Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA). Journal of Medicinal Chemistry. 33: 703-10. PMID 1967651 DOI: 10.1021/Jm00164A037 |
0.804 |
|
| 1990 |
Kohli JD, Glock D, Brewster WK, Knoerzer T, Nichols DE. A new potent and selective DA1 (vascular) dopamine receptor agonist European Journal of Pharmacology. 183: 1287. DOI: 10.1016/0014-2999(90)94395-E |
0.832 |
|
| 1989 |
Nichols DE, Oberlender R, Burris K, Hoffman AJ, Johnson MP. Studies of dioxole ring substituted 3,4-methylenedioxyamphetamine (MDA) analogues. Pharmacology, Biochemistry, and Behavior. 34: 571-6. PMID 2623014 DOI: 10.1016/0091-3057(89)90560-1 |
0.403 |
|
| 1989 |
Steele TD, Nichols DE, Yim GK. MDMA transiently alters biogenic amines and metabolites in mouse brain and heart. Pharmacology, Biochemistry, and Behavior. 34: 223-7. PMID 2576134 DOI: 10.1016/0091-3057(89)90303-1 |
0.309 |
|
| 1989 |
Lovenberg TW, Brewster WK, Mottola DM, Lee RC, Riggs RM, Nichols DE, Lewis MH, Mailman RB. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. European Journal of Pharmacology. 166: 111-3. PMID 2572425 DOI: 10.1016/0014-2999(89)90690-0 |
0.846 |
|
| 1989 |
Dimpfel W, Spüler M, Nichols DE. Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG). Psychopharmacology. 98: 297-303. PMID 2568652 DOI: 10.1007/Bf00451678 |
0.362 |
|
| 1989 |
McKenna DJ, Nazarali AJ, Hoffman AJ, Nichols DE, Mathis CA, Saavedra JM. Common receptors for hallucinogens in rat brain: a comparative autoradiographic study using [125I]LSD and [125I]DOI, a new psychotomimetic radioligand. Brain Research. 476: 45-56. PMID 2536576 DOI: 10.1016/0006-8993(89)91535-7 |
0.392 |
|
| 1989 |
Johnson MP, Nichols DE. Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. Pharmacology, Biochemistry, and Behavior. 33: 105-8. PMID 2476831 DOI: 10.1016/0091-3057(89)90437-1 |
0.411 |
|
| 1989 |
Mathis C, Gerdes J, Shulgin A, Hoffman A, Nichols D. Synthesis of high specific activity radiohalogenated amphetamine analogues for studies of the serotonin 5-HT2 receptor Journal of Labelled Compounds and Radiopharmaceuticals. 26: 130-132. DOI: 10.1002/JLCR.2580260157 |
0.495 |
|
| 1988 |
Nichols DE, Lloyd DH, Johnson MP, Hoffman AJ. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of Medicinal Chemistry. 31: 1406-12. PMID 3385733 DOI: 10.1021/Jm00402A026 |
0.512 |
|
| 1988 |
Oberlender R, Nichols DE. Drug discrimination studies with MDMA and amphetamine. Psychopharmacology. 95: 71-6. PMID 2898791 DOI: 10.1007/Bf00212770 |
0.315 |
|
| 1987 |
Riggs RM, Nichols DE, Foreman MM, Truex LL. Evaluation of isomeric 4-(chlorohydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines as dopamine D-1 antagonists. Journal of Medicinal Chemistry. 30: 1887-91. PMID 3656362 DOI: 10.1021/Jm00393A033 |
0.481 |
|
| 1987 |
Johnson MP, Hoffman AJ, Nichols DE, Mathis CA. Binding to the serotonin 5-HT2 receptor by the enantiomers of 125I-DOI. Neuropharmacology. 26: 1803-6. PMID 3437942 DOI: 10.1016/0028-3908(87)90138-9 |
0.497 |
|
| 1987 |
Riggs RM, McKenzie AT, Byrn SR, Nichols DE, Foreman MM, Truex LL. Effect of beta-alkyl substitution on D-1 dopamine agonist activity: absolute configuration of beta-methyldopamine. Journal of Medicinal Chemistry. 30: 1914-8. PMID 3309317 DOI: 10.1021/Jm00393A039 |
0.323 |
|
| 1987 |
Riggs RM, Nichols DE, Foreman MM, Truex LL, Glock D, Kohli JD. Specific dopamine D-1 and DA1 properties of 4-(mono- and -dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and its tetrahydrothieno[2,3-c]pyridine analogue. Journal of Medicinal Chemistry. 30: 1454-8. PMID 2956423 DOI: 10.1021/Jm00391A029 |
0.48 |
|
| 1987 |
Ricaurte GA, Finnegan KF, Nichols DE, DeLanney LE, Irwin I, Langston JW. 3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain. European Journal of Pharmacology. 137: 265-8. PMID 2886355 DOI: 10.1016/0014-2999(87)90233-0 |
0.38 |
|
| 1987 |
Steele TD, Nichols DE, Yim GK. Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical Pharmacology. 36: 2297-303. PMID 2886126 DOI: 10.1016/0006-2952(87)90594-6 |
0.367 |
|
| 1986 |
Nichols DE. Studies of the relationship between molecular structure and hallucinogenic activity. Pharmacology, Biochemistry, and Behavior. 24: 335-40. PMID 3952123 DOI: 10.1016/0091-3057(86)90362-X |
0.361 |
|
| 1986 |
Nichols DE, Hoffman AJ, Oberlender RA, Riggs RM. Synthesis and evaluation of 2,3-dihydrobenzofuran analogues of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane: drug discrimination studies in rats. Journal of Medicinal Chemistry. 29: 302-4. PMID 3950910 DOI: 10.1021/Jm00152A022 |
0.382 |
|
| 1986 |
Hoffman AJ, Maxwell DM, Nichols DE. A simple organ bath for electrical stimulation and superfusion of rat brain slices. Journal of Pharmacological Methods. 16: 185-99. PMID 3784567 DOI: 10.1016/0160-5402(86)90041-0 |
0.317 |
|
| 1986 |
Nichols DE, Hoffman AJ, Oberlender RA, Jacob P, Shulgin AT. Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class. Journal of Medicinal Chemistry. 29: 2009-15. PMID 3761319 DOI: 10.1021/Jm00160A035 |
0.343 |
|
| 1986 |
Johnson MP, Hoffman AJ, Nichols DE. Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices. European Journal of Pharmacology. 132: 269-76. PMID 2880735 DOI: 10.1016/0014-2999(86)90615-1 |
0.394 |
|
| 1986 |
Lloyd DH, Nichols DE. Nickel boride/hydrazine hydrate reduction of aromatic and aliphatic nitro compounds. Synthesis of 4-(benzyloxy)indole and .alpha.-alkyltryptamines The Journal of Organic Chemistry. 51: 4294-4295. DOI: 10.1021/JO00372A037 |
0.307 |
|
| 1985 |
Hoffman AJ, Nichols DE. Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives. Journal of Medicinal Chemistry. 28: 1252-5. PMID 4032428 DOI: 10.1021/Jm00147A022 |
0.358 |
|
| 1984 |
Oberlender RA, Kothari PJ, Nichols DE, Zabik JE. Substituent branching in phenethylamine-type hallucinogens: a comparison of 1-[2,5-dimethoxy-4-(2-butyl)phenyl]-2-aminopropane and 1-[2,5-dimethoxy-4-(2-methylpropyl)phenyl]-2-aminopropane. Journal of Medicinal Chemistry. 27: 788-92. PMID 6737421 DOI: 10.1021/Jm00372A015 |
0.414 |
|
| 1984 |
Nichols DE, Jacob JN, Hoffman AJ, Kohli JD, Glock D. C(2)-Methylation abolishes DA1 dopamine agonist activity of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): steric intolerance by the receptor. Journal of Medicinal Chemistry. 27: 1701-5. PMID 6502600 DOI: 10.1021/Jm00378A029 |
0.498 |
|
| 1984 |
Nichols DE, Schooler D, Yeung MC, Oberlender RA, Zabik JE. Unreliability of the rat stomach fundus as a predictor of hallucinogenic activity in substituted phenethylamines. Life Sciences. 35: 1343-8. PMID 6482656 DOI: 10.1016/0024-3205(84)90390-4 |
0.386 |
|
| 1984 |
Nichols DE, Jadhav KP, Oberlender RA, Zabik JE, Bossart JF, Hamada A, Miller DD. Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogues of hallucinogenic phenethylamines: lack of LSD-like biological activity. Journal of Medicinal Chemistry. 27: 1108-11. PMID 6471065 DOI: 10.1002/Chin.198505188 |
0.326 |
|
| 1984 |
Clemens JA, Fuller RW, Phebus LA, Smalstig EB, Hynes MD, Cassady JM, Nichols DE, Kelly E, Persons P. Stimulation of presynaptic dopamine autoreceptors by 4-(2-di-n-propylaminoethyl) indole (DPAI). Life Sciences. 34: 1015-22. PMID 6422174 DOI: 10.1016/0024-3205(84)90014-6 |
0.387 |
|
| 1982 |
Grosso JA, Nichols DE, Kohli JD, Glock D. Synthesis of 2-(alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines and evaluation as potential dopamine agonists. Journal of Medicinal Chemistry. 25: 703-8. PMID 7097723 DOI: 10.1021/Jm00348A018 |
0.413 |
|
| 1982 |
Nichols DE, Lloyd DH, Hoffman AJ, Nichols MB, Yim GK. Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes. Journal of Medicinal Chemistry. 25: 530-5. PMID 7086839 DOI: 10.1021/Jm00347A010 |
0.332 |
|
| 1982 |
Jacob JN, Nichols DE. Isomeric cyclopropyl ring-methylated homologues of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, an hallucinogen analogue. Journal of Medicinal Chemistry. 25: 526-30. PMID 7086838 DOI: 10.1021/Jm00347A009 |
0.325 |
|
| 1982 |
Hathaway BA, Nichols DE, Nichols MB, Yim GK. A new, potent, conformationally restricted analogue of amphetamine: 2-amino-1,2-dihydronaphthalene. Journal of Medicinal Chemistry. 25: 535-8. PMID 6123601 DOI: 10.1021/Jm00347A011 |
0.333 |
|
| 1982 |
Nichols DE, Lloyd DH, Hoffman AJ, Nichols MB, Yim GKW. Effects Of Certain Hallucinogenic Amphetamine Analogs On The Release Of (3H)-Serotonin From Rat Brain Synaptosomes Cheminform. 13. DOI: 10.1002/Chin.198241197 |
0.301 |
|
| 1982 |
Hathaway BA, Nichols DE, Nichols MB, Yim GKW. A New, Potent, Conformationally-Restricted Analog Of Amphetamine: 2-Amino-1,2-Dihydronaphthalene Cheminform. 13. DOI: 10.1002/Chin.198241176 |
0.325 |
|
| 1981 |
Jacob JN, Nichols DE, Kohli JD, Glock D. Dopamine agonist properties of N-alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines. Journal of Medicinal Chemistry. 24: 1013-5. PMID 7328594 DOI: 10.1021/Jm00140A021 |
0.354 |
|
| 1981 |
Kothari PJ, Hathaway BA, Nichols DE, Yim GK. Synthesis and serotonin-like activity of 2-amino-5,8-dimethoxy-6-methyl-1,2-dihydronaphthalene. Journal of Medicinal Chemistry. 24: 882-4. PMID 7277398 DOI: 10.1021/Jm00139A022 |
0.344 |
|
| 1980 |
Grosso JA, Nichols DE, Nichols MB, Yim GK. Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines. Journal of Medicinal Chemistry. 23: 1261-4. PMID 7452680 DOI: 10.1021/Jm00185A026 |
0.319 |
|
| 1979 |
Ginos JZ, Stevens JM, Nichols DE. Structure--activity relationships of n-substituted dopamine and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene analogues: behavioral effects in lesioned and reserpinized mice. Journal of Medicinal Chemistry. 22: 1323-9. PMID 574901 DOI: 10.1021/Jm00197A009 |
0.333 |
|
| 1979 |
Nichols DE, Kostuba LJ. Steric effects of substituents on phenethylamine hallucinogens. 3,4-(Methylenedioxy)amphetamine analogues alkylated on the dioxole ring. Journal of Medicinal Chemistry. 22: 1264-7. PMID 513074 DOI: 10.1021/Jm00196A022 |
0.349 |
|
| 1979 |
Kohli JD, Goldberg LI, Nichols DE. Dopamine vascular actions of N-substituted derivatives of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN). European Journal of Pharmacology. 56: 39-44. PMID 467513 DOI: 10.1016/0014-2999(79)90430-8 |
0.345 |
|
| 1979 |
Nichols DE, Woodard R, Hathaway BA, Lowy MT, Yom KW. Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analogue. Journal of Medicinal Chemistry. 22: 458-60. PMID 430485 DOI: 10.1021/Jm00190A021 |
0.371 |
|
| 1978 |
Nichols DE, Pfister WR, Yim GK. LSD and phenethylamine hallucinogens: new structural analogy and implications for receptor geometry. Life Sciences. 22: 2165-70. PMID 672453 DOI: 10.1016/0024-3205(78)90567-2 |
0.403 |
|
| 1978 |
Nichols DE, Toth JE, Kohli JD, Kotake CK. 2,3-Dihydroxy-9-amino-9,10-dihydrophenanthrene, a rigid congener of dopamine and isoapomorphine. Journal of Medicinal Chemistry. 21: 395-8. PMID 650669 DOI: 10.1021/Jm00202A017 |
0.392 |
|
| 1978 |
Nichols DE, Weintraub HJ, Pfister WR, Yim GK. The use of rigid analogues to probe hallucinogen receptors. Nida Research Monograph. 70-83. PMID 101889 |
0.321 |
|
| 1977 |
Nichols DE, Shulgin AT, Dyer DC. Directional lipophilic character in a series of psychotomimetic phenethylamine derivatives. Life Sciences. 21: 569-75. PMID 904435 DOI: 10.1016/0024-3205(77)90099-6 |
0.406 |
|
| 1977 |
Nichols DE, Dyer DC. Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues. Journal of Medicinal Chemistry. 20: 299-301. PMID 836502 DOI: 10.1021/Jm00212A022 |
0.433 |
|
| 1976 |
Nichols DE. Structural correlation between apomorphine and LSD: involvement of dopamine as well as serotonin in the actions of hallucinogens. Journal of Theoretical Biology. 59: 167-77. PMID 7711 DOI: 10.1016/S0022-5193(76)80030-6 |
0.453 |
|
| 1975 |
Barfknecht CF, Nichols DE. Correlation of psychotomimetic activity of phenethylamines and amphetamines with 1-octanol-water partition coefficients. Journal of Medicinal Chemistry. 18: 208-10. PMID 1120990 DOI: 10.1002/Chin.197525187 |
0.602 |
|
| 1975 |
Ilhan M, Nichols DE, Long JP, Cannon JG. Apomorphine-like effect of an aminotetralin on the linguomandibular reflex of the cat. European Journal of Pharmacology. 33: 61-4. PMID 240731 DOI: 10.1016/0014-2999(75)90138-7 |
0.509 |
|
| 1974 |
Cheng HC, Long JP, Nichols DE, Barfknecht CF, Rusterholz DB. Effects of rigid amphetamine analogs on vascular strips: studies of 2-aminotetrahydronaphthalene and 2-aminoindan derivatives. Archives Internationales De Pharmacodynamie Et De ThéRapie. 208: 264-73. PMID 4851775 |
0.58 |
|
| 1974 |
Cheng HC, Long JP, Nichols DE, Barfknecht CF. Effects of psychotomimetics on vascular strips: studies of methoxylated amphetamines and optical isomers of 2,5-dimethoxy-4-methylamphetamine and 2,5-dimethoxy-4-bromoamphetamine. The Journal of Pharmacology and Experimental Therapeutics. 188: 114-23. PMID 4809263 |
0.552 |
|
| 1974 |
Nichols DE, Barfknecht CF, Long JP, Standridge RT, Howell HG, Partyka RA, Dyer DC. Potential psychotomimetics. 2. Rigid analogs of 2,5-dimethoxy-4-methylphenylisopropylamine (DOM, STP). Journal of Medicinal Chemistry. 17: 161-6. PMID 4809251 DOI: 10.1021/Jm00248A004 |
0.608 |
|
| 1974 |
Cheng HC, Long JP, Nichols DE, Barfknecht CF. Effects of para-methoxyamphetamine (PMA) on the cardiovascular system of the dog. Archives Internationales De Pharmacodynamie Et De ThéRapie. 212: 83-8. PMID 4455128 |
0.535 |
|
| 1974 |
NICHOLS DE, BARFKNECHT CF, LONG JP, STANDRIDGE RT, HOWELL HG, PARTYKA RA, DYER DC. ChemInform Abstract: POTENTIAL PSYCHOTOMIMETICS PART 2, RIGID ANALOGS OF 2,5-DIMETHOXY-4-METHYLPHENYLISOPROPYLAMINE (DOM,STP) Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197425249 |
0.61 |
|
| 1973 |
Dyer DC, Nichols DE, Rusterholz DB, Barfknecht CF. Comparative effects of stereoisomers of psychotomimetic phenylisopropylamines. Life Sciences. 13: 885-96. PMID 4766265 DOI: 10.1016/0024-3205(73)90079-9 |
0.635 |
|
| 1973 |
Barfknecht CF, Nichols DE, Rusterholz DB, Long JP, Engelbrecht JA, Beaton JM, Bradley RJ, Dyer DC. Potential psychotomimetics. 2-Amino-1,2,3,4-tetrahydronaphthalene analogs. Journal of Medicinal Chemistry. 16: 804-8. PMID 4725926 DOI: 10.1002/Chin.197342259 |
0.594 |
|
| 1973 |
Cheng HC, Long JP, Barfknecht CF, Nichols DE. Cardiovascular effects of 2, 5-dimethoxy-4-methylamphetamine (DOM, STP). The Journal of Pharmacology and Experimental Therapeutics. 186: 345-54. PMID 4719787 |
0.539 |
|
| 1973 |
Nichols DE, Barfknecht CF, Rusterholz DB, Benington F, Morin RD. Asymmetric synthesis of psychotomimetic phenylisopropylamines. Journal of Medicinal Chemistry. 16: 480-3. PMID 4718460 DOI: 10.1021/Jm00263A013 |
0.607 |
|
| 1973 |
Nichols DE, Barfknecht CF. 1-Methyl-3-piperidone and 1-methyl-3-pyrrolidone derivatives from a dieckmann reaction Journal of Heterocyclic Chemistry. 10: 339-341. DOI: 10.1002/Jhet.5570100311 |
0.557 |
|
| 1973 |
NICHOLS DE, BARFKNECHT CF. ChemInform Abstract: 1-METHYL-3-PIPERIDONE AND 1-METHYL-3-PYRROLIDONE DERIVATIVES FROM A DIECKMANN REACTION Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/chin.197345340 |
0.546 |
|
| 1972 |
Engelbrecht JA, Long JP, Nichols DE, Barfknecht CF. Pharmacologic evaluation of 3,4-dimethoxyphenylpropenes and 3,4-dimethoxyphenylpropanediols. Archives Internationales De Pharmacodynamie Et De ThéRapie. 199: 226-44. PMID 5070643 |
0.554 |
|
| 1972 |
Barfknecht CF, Nichols DE. Effects of S-(+)- and R-(-)-3,4,dimethoxyphenylisopropylamines in the rat. Journal of Medicinal Chemistry. 15: 109-10. PMID 5007083 DOI: 10.1021/Jm00271A037 |
0.595 |
|
| 1971 |
Barfknecht CF, Nichols DE. Potential psychotomimetics. Bromomethoxyamphetamines. Journal of Medicinal Chemistry. 14: 370-2. PMID 5553756 DOI: 10.1021/Jm00286A026 |
0.573 |
|
| 1971 |
Antun F, Smythies JR, Benington F, Morin RD, Barfknecht CF, Nichols DE. Native fluorescence and hallucinogenic potency of some amphetamines. Experientia. 27: 62-3. PMID 5549244 DOI: 10.1007/BF02137743 |
0.559 |
|
| 1971 |
Barfknecht CF, Smith RV, Nichols DE, Leseney JL, Long JP, Engelbrecht JA. Chemistry and pharmacological evaluation of 1-phenyl-2-propanols and 1-phenyl-2-propanones. Journal of Pharmaceutical Sciences. 60: 799-801. PMID 5125790 DOI: 10.1002/Jps.2600600533 |
0.598 |
|
| 1971 |
BARFKNECHT CF, SMITH RV, NICHOLS DE, LESENEY JL, LONG JP, ENGELBRECHT JA. ChemInform Abstract: CHEMIE UND PHARMAKOLOGISCHE BEWERTUNG VON 1-PHENYLPROPANOLEN-(2)(I) UND 1-PHENYLPROPANONEN-(2)(II) Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197136272 |
0.522 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1984 |
OBERLENDER RA, KOTHARI PJ, NICHOLS DE, ZABIK JE. ChemInform Abstract: SUBSTITUENT BRANCHING IN PHENETHYLAMINE-TYPE HALLUCINOGENS: A COMPARISON OF 1-(2,5-DIMETHOXY-4-(2-BUTYL)PHENYL)-2-AMINOPROPANE AND 1-(2,5-DIMETHOXY-4-(2-METHYLPROPYL)PHENYL)-2-AMINOPROPANE Chemischer Informationsdienst. 15. DOI: 10.1002/CHIN.198444133 |
0.298 |
|
| 1976 |
Nichols DE, Shulgin AT. Sulfur analogs of psychotomimetic amines. Journal of Pharmaceutical Sciences. 65: 1554-6. PMID 978423 DOI: 10.1002/Jps.2600651040 |
0.296 |
|
| 2012 |
Nichols DE. Structure-activity relationships of serotonin 5-HT2A agonists Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1: 559-579. DOI: 10.1002/wmts.42 |
0.296 |
|
| 2010 |
GHOSH D, SNYDER SE, WATTS VJ, MAILMAN RB, NICHOLS DE. ChemInform Abstract: 8,9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph(1,2,3-de)isoquinoline: A Potent Full Dopamine D1 Agonist Containing a Rigid β- Phenyldopamine Pharmacophore. Cheminform. 27: no-no. DOI: 10.1002/chin.199619167 |
0.294 |
|
| 1987 |
Oberlender R, Nichols DE, Ramachandran PV, Srebnik M. Tomoxetine and the stereoselectivity of drug action. The Journal of Pharmacy and Pharmacology. 39: 1055-6. PMID 2894441 DOI: 10.1111/J.2042-7158.1987.Tb03164.X |
0.29 |
|
| 1980 |
Weintraub HJ, Nichols DE, Makriyannis A, Fesik SW. Conformational energy differences between side chain alkylated analogues of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane. Journal of Medicinal Chemistry. 23: 339-41. PMID 7365752 DOI: 10.1002/Chin.198034159 |
0.286 |
|
| 2010 |
Torres-Altoro MI, Kuntz CP, Nichols DE, Barker EL. Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway. The Journal of Biological Chemistry. 285: 15369-79. PMID 20304925 DOI: 10.1074/jbc.M109.088138 |
0.285 |
|
| 1992 |
Huang X, Marona-Lewicka D, Nichols DE. p-methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent. European Journal of Pharmacology. 229: 31-8. PMID 1473561 DOI: 10.1016/0014-2999(92)90282-9 |
0.284 |
|
| 1995 |
Sprague JE, Nichols DE. The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. The Journal of Pharmacology and Experimental Therapeutics. 273: 667-73. PMID 7538579 |
0.284 |
|
| 1983 |
Si EC, Nichols DE, Holsapple MP, Yim GK. In vitro and in vivo evaluation of cis-methyl-phencyclidine (CIS-MPCP) as a potential antagonist of phencyclidine (PCP). Life Sciences. 33: 909-15. PMID 6604211 DOI: 10.1016/0024-3205(83)90746-4 |
0.284 |
|
| 1981 |
Migliaccio GP, Shieh TL, Byrn SR, Hathaway BA, Nichols DE. Comparison of solution conformational preferences for the hallucinogens bufotenin and psilocin using 360-MHz proton NMR spectroscopy. Journal of Medicinal Chemistry. 24: 206-9. PMID 6259355 DOI: 10.1002/Chin.198128356 |
0.28 |
|
| 1995 |
Ghosh D, Nichols DE. An unusual formation of a novel spiroisoquinolone ring Tetrahedron Letters. 36: 823-824. DOI: 10.1016/0040-4039(94)02417-A |
0.275 |
|
| 1991 |
Johnson MP, Frescas SP, Oberlender R, Nichols DE. Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA). Journal of Medicinal Chemistry. 34: 1662-8. PMID 1674539 |
0.272 |
|
| 1977 |
Nichols DE, Mason DL, Jacobsen LB. Allylbenzene analogs of delta9-tetrahydrocannabinol as tumor growth inhibitors. Life Sciences. 21: 1245-8. PMID 927027 DOI: 10.1016/0024-3205(77)90004-2 |
0.272 |
|
| 1988 |
Mathis CA, Hoffman AJ, Nichols DE, Shulgin AT. Synthesis of high specific activity 125I- and 123I-labelled enantiomers of 2,5-dimethoxy-4-iodophenylisopropylamine (DOI) Journal of Labelled Compounds and Radiopharmaceuticals. 25: 1255-1265. DOI: 10.1002/JLCR.2580251112 |
0.27 |
|
| 1991 |
Witkin JM, Nichols DE, Terry P, Katz JL. Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections. The Journal of Pharmacology and Experimental Therapeutics. 257: 706-13. PMID 1674533 |
0.27 |
|
| 1982 |
Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Medica. 45: 31-4. PMID 17396775 DOI: 10.1055/s-2007-971236 |
0.262 |
|
| 2009 |
Nichols DE, Weintraub HJR. Effects of steric interactions on models of charge-transfer complexes: A preliminary report International Journal of Quantum Chemistry. 22: 205-211. DOI: 10.1002/QUA.560220720 |
0.262 |
|
| 1998 |
Sprague JE, Everman SL, Nichols DE. An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology. 19: 427-41. PMID 9621349 |
0.256 |
|
| 2006 |
Nichols DE. Commentary on: Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance by Griffiths et al Psychopharmacology. 187: 284-286. DOI: 10.1007/s00213-006-0458-4 |
0.255 |
|
| 2012 |
Bekkam M, Mo H, Nichols DE. A reported "new synthesis of lysergic acid" yields only the derailment product: methyl 5-methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate. Organic Letters. 14: 296-8. PMID 22176338 DOI: 10.1021/ol203048q |
0.252 |
|
| 2007 |
Gallardo-Godoy A, Torres-Altoro MI, White KJ, Barker EL, Nichols DE. 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Bioorganic & Medicinal Chemistry. 15: 305-11. PMID 17064910 DOI: 10.1016/J.Bmc.2006.09.058 |
0.248 |
|
| 1977 |
Pummangura S, Nichols DE, McLaughlin JL. Cactus alkaloids XXXIII: beta-phenethylamines from the Guatemalan cactus Pilosocereus maxonii. Journal of Pharmaceutical Sciences. 66: 1485-7. PMID 925910 DOI: 10.1002/Jps.2600661037 |
0.244 |
|
| 1997 |
Nichols DE. The Chemistry of Mind-Altering Drugs. History, Pharmacology, and Cultural Context By Daniel M. Perrine. American Chemical Society, Washington, D.C. 1996. x + 480 pp. 17.5 × 25 cm. ISBN 0-8412-3253-9. $39.95. Journal of Medicinal Chemistry. 40: 3859-3859. DOI: 10.1021/jm970450a |
0.244 |
|
| 1990 |
Oberlender R, Nichols DE. (+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine as a discriminative stimulus in studies of 3,4-methylenedioxy-methamphetamine-like behavioral activity. The Journal of Pharmacology and Experimental Therapeutics. 255: 1098-106. PMID 1979813 |
0.236 |
|
| 1988 |
Boyles DA, Nichols DE. Formal synthesis of clavicipitic acid based on biosynthetic proposal The Journal of Organic Chemistry. 53: 5128-5130. DOI: 10.1021/JO00256A039 |
0.235 |
|
| 1986 |
Nichols DE. Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. Journal of Psychoactive Drugs. 18: 305-13. PMID 2880944 DOI: 10.1080/02791072.1986.10472362 |
0.235 |
|
| 1981 |
Nichols DE. Structure-activity relationships of phenethylamine hallucinogens. Journal of Pharmaceutical Sciences. 70: 839-49. PMID 7031221 DOI: 10.1002/Jps.2600700802 |
0.234 |
|
| 2007 |
Banks ML, Sprague JE, Kisor DF, Czoty PW, Nichols DE, Nader MA. Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1840-5. PMID 17640955 DOI: 10.1124/Dmd.107.016261 |
0.233 |
|
| 1993 |
Nichols DE, Marona-Lewicka D, Huang X, Johnson MP. Novel serotonergic agents. Drug Design and Discovery. 9: 299-312. PMID 8400010 |
0.232 |
|
| 2005 |
Sprague JE, Nichols DE. Neurotoxicity of MDMA (ecstasy): beyond metabolism. Trends in Pharmacological Sciences. 26: 59-60; author reply . PMID 15681020 DOI: 10.1016/J.Tips.2004.12.001 |
0.23 |
|
| 2015 |
Hoehn RD, Nichols D, Neven H, Kais S. Neuroreceptor activation by vibration-assisted tunneling. Scientific Reports. 5: 9990. PMID 25909758 DOI: 10.1038/Srep09990 |
0.228 |
|
| 2017 |
Young J, Graves M, Milienne-Petiot M, Nichols D, Twamley E, Geyer M. SA113. Dopamine D1 Receptor Activation Improves Reward-Associative Learning in a Mouse Probabilistic Learning Task Schizophrenia Bulletin. 43: S153-S154. DOI: 10.1093/Schbul/Sbx023.111 |
0.225 |
|
| 1981 |
Holsapple MP, Chun A, Lagally RW, Nichols DE, Yim GK. Reduction of aspirin-induced ulcers by a new imidazoline anti-inflammatory agent. Agents and Actions. 11: 718-22. PMID 7340463 DOI: 10.1007/Bf01978795 |
0.224 |
|
| 1987 |
Nichols DE. Discovery of novel psychoactive drugs: has it ended? Journal of Psychoactive Drugs. 19: 33-7. PMID 3585593 DOI: 10.1080/02791072.1987.10472377 |
0.22 |
|
| 2015 |
White KL, Robinson JE, Zhu H, DiBerto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL. The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo. The Journal of Pharmacology and Experimental Therapeutics. 352: 98-109. PMID 25320048 DOI: 10.1124/Jpet.114.216820 |
0.22 |
|
| 2006 |
Callaway JC, Grob CS, McKenna DJ, Nichols DE, Shulgin A, Tupper KW. A demand for clarity regarding a case report on the ingestion of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation. Journal of Analytical Toxicology. 30: 406-7; author reply . PMID 16872575 DOI: 10.1093/Jat/30.6.406 |
0.219 |
|
| 2006 |
Nichols DE. Synthesis of Essential Drugs By Ruben Vardanyan and Victor Hruby. Elsevier, Amsterdam, The Netherlands. 2006. xvi + 617 pp. 17 × 24.5 cm. ISBN 10 0-444-52166-6. $240.00. Journal of Medicinal Chemistry. 49: 7554-7555. DOI: 10.1021/jm0680373 |
0.218 |
|
| 1985 |
NICHOLS DE, JADHAV KP, OBERLENDER RA, ZABIK JE, BOSSART JF, HAMADA A, MILLER DD. ChemInform Abstract: SYNTHESIS AND EVALUATION OF SUBSTITUTED 2-PHENYLCYCLOBUTYLAMINES AS ANALOGS OF HALLUCINOGENIC PHENETHYLAMINES: LACK OF LSD-LIKE BIOLOGICAL ACTIVITY Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198505188 |
0.217 |
|
| 2018 |
Halberstadt AL, Klein LM, Chatha M, Valenzuela LB, Stratford A, Wallach J, Nichols DE, Brandt SD. Correction to: Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA). Psychopharmacology. PMID 30443792 DOI: 10.1007/S00213-018-5117-Z |
0.216 |
|
| 1998 |
Nichols DE. Highly Selective Neurotoxins. Basic and Clinical Applications Edited by R. M. Kostrzewa. Humana Press, Towota, NJ. 1998. xii + 404 pp. 16 × 23.5 cm. ISBN 0-89603-465-8. $125.00. Journal of Medicinal Chemistry. 41: 2171-2172. DOI: 10.1021/jm980207r |
0.216 |
|
| 1980 |
McCarty KS, Woodard BH, Nichols DE, Wilkinson W, McCarty KS. Comparison of biochemical and histochemical techniques for estrogen receptor analyses in mammary carcinoma. Cancer. 46: 2842-5. PMID 6256053 DOI: 10.1002/1097-0142(19801215)46:12+<2842::Aid-Cncr2820461422>3.0.Co;2-O |
0.216 |
|
| 1998 |
Nichols DE. The Impact of Stereochemistry on Drug Development and Use. Volume 142 in Chemical Analysis. Edited by H. Y. Aboul-Enein and I. W. Wainer. John Wiley & Sons, New York. 1997. xxvii + 695 pp. 16 × 23.5 cm. ISBN 0-471-59644-2. $99.00 Journal of Medicinal Chemistry. 41: 1556-1556. DOI: 10.1021/Jm980005V |
0.211 |
|
| 1971 |
BARFKNECHT CF, NICHOLS DE. ChemInform Abstract: POTENTIELLE PSYCHOTOMIMETICA, BROMMETHOXYAMPHETAMINE Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/CHIN.197130223 |
0.208 |
|
| 1996 |
Li Q, Murakami I, Stall S, Levy AD, Brownfield MS, Nichols DE, Van de Kar LD. Neuroendocrine pharmacology of three serotonin releasers: 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAi) and p-methylthioamphetamine (MTA). The Journal of Pharmacology and Experimental Therapeutics. 279: 1261-7. PMID 8968349 |
0.202 |
|
| 2014 |
Nichols DE. The Heffter Research Institute: past and hopeful future. Journal of Psychoactive Drugs. 46: 20-6. PMID 24830182 DOI: 10.1080/02791072.2014.873688 |
0.196 |
|
| 1986 |
Nichols DE. Drugs in Central Nervous System Disorders Journal of Pharmaceutical Sciences. 75: 102. DOI: 10.1002/jps.2600750125 |
0.193 |
|
| 2022 |
Nichols DE. Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated. Frontiers in Psychiatry. 13: 863088. PMID 35401275 DOI: 10.3389/fpsyt.2022.863088 |
0.192 |
|
| 2010 |
Nichols D. Highs and lows Nature Chemistry. 2: 153-153. DOI: 10.1038/nchem.558 |
0.192 |
|
| 2010 |
NEGASH K, NICHOLS DE. ChemInform Abstract: A New Approach for the Synthesis of (.+-.)-trans-10,11-Dihydroxy-5,6, 6a,7,8,12b-hexahydrobenzo(a)phenanthridine (Dihydrexidine). Cheminform. 27: no-no. DOI: 10.1002/CHIN.199652124 |
0.191 |
|
| 1999 |
Nichols DE. Designer Drugs Directory By Karel Valter and Philippe Arrizabalaga. Edited by Jean-Claude Landry. Elsevier Science, Lausanne, Switzerland. 1998. 212 pp. 17 x 25 cm. ISBN 0-444-20525-X. $154.00. Journal of Medicinal Chemistry. 42: 1681-1681. DOI: 10.1021/JM990120L |
0.187 |
|
| 2015 |
Jarmusch AK, Musso AM, Shymanovich T, Jarmusch SA, Weavil MJ, Lovin ME, Ehrmann BM, Saari S, Nichols DE, Faeth SH, Cech NB. Comparison of electrospray ionization and atmospheric pressure photoionization liquid chromatography mass spectrometry methods for analysis of ergot alkaloids from endophyte-infected sleepygrass (Achnatherum robustum). Journal of Pharmaceutical and Biomedical Analysis. 117: 11-17. PMID 26340558 DOI: 10.1016/J.Jpba.2015.08.031 |
0.183 |
|
| 1984 |
Nichols DE, Oberlender R. Behavioral techniques in neuroreceptor research. Monographs in Neural Sciences. 10: 108-19. PMID 6321967 DOI: 10.1159/000408385 |
0.178 |
|
| 2010 |
MONTE AP, WALDMAN SR, MARONA-LEWICKA D, WAINSCOTT DB, NELSON DL, SANDERS-BUSH E, NICHOLS DE. ChemInform Abstract: Dihydrobenzofuran Analogues of Hallucinogens. Part 4. Mescaline Derivatives. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199801111 |
0.176 |
|
| 1987 |
LLOYD DH, NICHOLS DE. ChemInform Abstract: Nickel Boride/Hydrazine Hydrate: Reduction of Aromatic and Aliphatic Nitro Compounds. Synthesis of 4-(Benzyloxy)indole and α-Alkyltryptamines. Cheminform. 18. DOI: 10.1002/CHIN.198717199 |
0.172 |
|
| 2010 |
MONTE AP, MARONA-LEWICKA D, COZZI NV, NELSON DL, NICHOLS DE. ChemInform Abstract: Conformationally Restricted Tetrahydro-1-benzoxepin Analogues of Hallucinogenic Phenethylamines. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199621182 |
0.168 |
|
| 1979 |
NICHOLS DE, WOODARD R, HATHAWAY BA, LOWY MT, YIM GKW. ChemInform Abstract: RESOLUTION AND ABSOLUTE CONFIGURATION OF TRANS-2-(2,5-DIMETHOXY-4-METHYLPHENYL)CYCLOPROPYLAMINE, A POTENT HALLUCINOGEN ANALOG Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197934197 |
0.165 |
|
| 2010 |
JOHNSON MP, FRESCAS SP, OBERLENDER R, NICHOLS DE. ChemInform Abstract: Synthesis and Pharmacological Examination of 1-(3-Methoxy-4-methylphenyl)-2-aminopropane and 5-Methoxy-6-methyl-2-aminoindan: Similarities to 3,4-(Methylenedioxy)methamphetamine (MDMA). Cheminform. 22: no-no. DOI: 10.1002/CHIN.199145138 |
0.161 |
|
| 2018 |
Halberstadt AL, Klein LM, Chatha M, Valenzuela LB, Stratford A, Wallach J, Nichols DE, Brandt SD. Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA). Psychopharmacology. PMID 30298278 DOI: 10.1007/S00213-018-5055-9 |
0.16 |
|
| 1996 |
Negash K, Nichols DE. A new approach for the synthesis of (±)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthrid ine (dihydrexidine) Tetrahedron Letters. 37: 6971-6972. DOI: 10.1016/0040-4039(96)01574-2 |
0.158 |
|
| 1979 |
Rusterholz DB, Long JP, Nichols DE. Effect of alpha-methyltryptamine on spontaneous activity in mice. Pharmacology, Biochemistry, and Behavior. 10: 223-7. PMID 156369 DOI: 10.1016/0091-3057(79)90091-1 |
0.157 |
|
| 1990 |
NICHOLS DE, CASSADY JM, PERSONS PE, YEUNG MC, CLEMENS JA, SMALSTIG EB. ChemInform Abstract: Synthesis and Evaluation of N,N-Di(n-propyl)tetrahydrobenz(f)indol-7-amine and Related Congeners as Dopaminergic Agonists. Cheminform. 21. DOI: 10.1002/CHIN.199008144 |
0.154 |
|
| 1978 |
NICHOLS DE, ROBINSON JM, LI GS, CASSADY JM, FLOSS HG. ChemInform Abstract: AN IMPROVED SYNTHESIS OF 1-BENZOYL-4-OXO-1,2,2A,3,4,5-HEXAHYDROBENZ(CD)INDOLE Chemischer Informationsdienst. 9. DOI: 10.1002/chin.197816178 |
0.153 |
|
| 1982 |
Ferrigni NR, Nichols DE, McLaughlin JL, Bye RA. Cactus alkaloids. XLVII. N alpha-dimethylhistamine, a hypotensive component of Echinocereus triglochidiatus. Journal of Ethnopharmacology. 5: 359-64. PMID 7087506 DOI: 10.1016/0378-8741(82)90017-4 |
0.152 |
|
| 1978 |
Pfister WR, Noland V, Lowy MT, Nichols DE, Yim GK. Comparison of the behavioral effects of para-chloroamphetamine, chlordimeform, quipazine, and intraventricular serotonin in the rat. Communications in Psychopharmacology. 2: 287-95. PMID 729354 |
0.15 |
|
| 1989 |
Nichols DE, Cassady JM, Persons PE, Yeung MC, Clemens JA, Smalstig EB. Synthesis and evaluation of N,N-di-n-propyltetrahydrobenz[f]indol-7-amine and related congeners as dopaminergic agonists. Journal of Medicinal Chemistry. 32: 2128-34. PMID 2570151 |
0.149 |
|
| 1990 |
MAYER JP, CASSADY JM, NICHOLS DE. ChemInform Abstract: An Improved Synthesis of 6-Hydroxy-4-(2-(di-n-propylamino)ethyl)indole. Cheminform. 21. DOI: 10.1002/CHIN.199050326 |
0.146 |
|
| 1977 |
Nichols DE, Robinson JM, Li GS, Cassady JM, Floss HG. AN IMPROVED SYNTHESIS OF 1-BENZOYL-4-KETO-1,2,2A,3,4,5-HEXAHYDROBENZ [cd]INDOLE Organic Preparations and Procedures International. 9: 277-280. DOI: 10.1080/00304947709356088 |
0.145 |
|
| 2023 |
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T. Ligand and G-protein selectivity in the κ-opioid receptor. Nature. PMID 37138078 DOI: 10.1038/s41586-023-06030-7 |
0.135 |
|
| 2018 |
Volgin AD, Yakovlev OV, Demin KA, Alekseeva PA, Kyzar E, Collins C, Nichols DE, Kalueff A. Understanding CNS effects of deliriant hallucinogenic drugs through experimental animal models. Acs Chemical Neuroscience. PMID 30252437 DOI: 10.1021/acschemneuro.8b00433 |
0.13 |
|
| 1987 |
Gill MT, Bajaj R, Chang CJ, Nichols DE, McLaughlin JL. 3,3',5'-Tri-O-methylpiceatannol and 4,3',5'-tri-O-methylpiceatannol: improvements over piceatannol in bioactivity. Journal of Natural Products. 50: 36-40. PMID 3598597 DOI: 10.1021/Np50049A006 |
0.129 |
|
| 2008 |
Perez A, van Heeckeren AM, Nichols D, Gupta S, Eastman JF, Davis PB. Peroxisome proliferator-activated receptor-gamma in cystic fibrosis lung epithelium. American Journal of Physiology. Lung Cellular and Molecular Physiology. 295: L303-13. PMID 18556801 DOI: 10.1152/Ajplung.90276.2008 |
0.127 |
|
| 1983 |
Meyer BN, Helfrich JS, Nichols DE, McLaughlin JL, Davis DV, Cooks RG. Cactus Alkaloids. LIII. Coryphanthine and O-Methyl-Candicine, Two New Quaternary Alkaloids from Coryphantha greenwoodii Journal of Natural Products. 46: 688-693. DOI: 10.1021/Np50029A017 |
0.126 |
|
| 2016 |
Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Colestock T, Burrow TE, Chapman SJ, Stratford A, Nichols DE, Halberstadt AL. Return of the lysergamides. Part II: Analytical and behavioural characterization of N(6) -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ). Drug Testing and Analysis. PMID 27265891 DOI: 10.1002/Dta.1985 |
0.125 |
|
| 2001 |
Sprague JE, Worst TJ, Haynes K, Mosler CR, Nichols DE, Kane MD. The pharmacodynamic characterization of an antisense oligonucleotide against monoamine oxidase-B (MAO-B) in rat brain striatal tissue. Cellular and Molecular Neurobiology. 21: 53-64. PMID 11440198 DOI: 10.1023/A:1007121312399 |
0.124 |
|
| 2010 |
Geyer MA, Nichols DE, Vollenweider FX. Serotonin-related psychedelic drugs Encyclopedia of Neuroscience. 731-738. DOI: 10.1016/B978-008045046-9.01160-8 |
0.123 |
|
| 2017 |
Nichols DE. N,N-dimethyltryptamine and the pineal gland: Separating fact from myth. Journal of Psychopharmacology (Oxford, England). 269881117736919. PMID 29095071 DOI: 10.1177/0269881117736919 |
0.12 |
|
| 2017 |
Higa KK, Young JW, Ji B, Nichols DE, Geyer MA, Zhou X. Striatal dopamine D1 receptor suppression impairs reward-associative learning. Behavioural Brain Research. PMID 28143767 DOI: 10.1016/J.Bbr.2017.01.041 |
0.12 |
|
| 2018 |
Fonouni-Farde C, McAdam E, Nichols D, Diet A, Foo E, Frugier F. Cytokinins and the CRE1 receptor influence endogenous gibberellin levels in Medicago truncatula. Plant Signaling & Behavior. 0. PMID 29373072 DOI: 10.1080/15592324.2018.1428513 |
0.119 |
|
| 1978 |
Braun U, Braun G, Jacob P, Nichols DE, Shulgin AT. Mescaline analogs: substitutions at the 4-position. Nida Research Monograph. 27-37. PMID 101882 |
0.118 |
|
| 2015 |
Brandt SD, Elliott SP, Kavanagh PV, Dempster NM, Meyer MR, Maurer HH, Nichols DE. Analytical characterization of bioactive N-benzyl-substituted phenethylamines and 5-methoxytryptamines. Rapid Communications in Mass Spectrometry : Rcm. 29: 573-84. PMID 26212274 DOI: 10.1002/rcm.7134 |
0.118 |
|
| 2017 |
Brandt SD, Kavanagh PV, Westphal F, Elliott SP, Wallach J, Stratford A, Nichols DE, Halberstadt AL. Return of the lysergamides. Part III: Analytical characterization of N(6) -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD). Drug Testing and Analysis. PMID 28342178 DOI: 10.1002/Dta.2196 |
0.117 |
|
| 2018 |
Nichols DE. Dark Classics in Chemical Neuroscience: Lysergic acid diethylamide (LSD). Acs Chemical Neuroscience. PMID 29461039 DOI: 10.1021/acschemneuro.8b00043 |
0.114 |
|
| 1975 |
Nichols DE, Ilhan M, Long JP. Comparison of cardiovascular, hyperthermic, and toxic effects of para-methoxyamphetamine (PMA) and 3, 4-methylenedioxyamphetamine (MDA). Archives Internationales De Pharmacodynamie Et De ThéRapie. 214: 133-40. PMID 1174022 |
0.113 |
|
| 1989 |
Nichols DE, Oberlender R. Structure-activity relationships of MDMA-like substances. Nida Research Monograph. 94: 1-29. PMID 2575223 |
0.104 |
|
| 1973 |
BARFKNECHT CF, NICHOLS DE, RUSTERHOLZ DB, LONG JP, ENGELBRECHT JA, BEATON JM, BRADLEY RJ, DYER DC. ChemInform Abstract: POTENTIAL PSYCHOTOMIMETICS, 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE ANALOGS Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/chin.197342259 |
0.104 |
|
| 1995 |
Lee S, Frescas SP, Nichols DE. A new, simple procedure for the preparation of 8-methoxy-2-tetralone Synthetic Communications. 25: 2775-2780. DOI: 10.1080/00397919508011824 |
0.103 |
|
| 1978 |
Anderson GM, Braun G, Braun U, Nichols DE, Shulgin AT. Absolute configuration and psychotomimetic activity. Nida Research Monograph. 8-15. PMID 101890 |
0.101 |
|
| 1996 |
Waldman SR, Monte AP, Bracey A, Nichols DE. One-pot Claisen rearrangement/O-methylation/alkene isomerization in the synthesis of ortho-methoxylated phenylisopropylamines Tetrahedron Letters. 37: 7889-7892. DOI: 10.1016/0040-4039(96)01807-2 |
0.099 |
|
| 1980 |
WEINTRAUB HJR, NICHOLS DE, MAKRIYANNIS A, FESIK SW. ChemInform Abstract: CONFORMATIONAL ENERGY DIFFERENCES BETWEEN SIDE CHAIN ALKYLATED ANALOGS OF THE HALLUCINOGEN 1-(2,5-DIMETHOXY-4-METHYLPHENYL)-2-AMINOPROPANE Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198034159 |
0.095 |
|
| 2001 |
Tian F, Chang CJ, Grutzner JB, Nichols DE, McLaughlin JL. Robinlin: a novel bioactive homo-monoterpene from Robinia pseudoacacia L. (Fabaceae). Bioorganic & Medicinal Chemistry Letters. 11: 2603-6. PMID 11551759 DOI: 10.1016/S0960-894X(01)00514-5 |
0.094 |
|
| 1989 |
BOYLES DA, NICHOLS DE. ChemInform Abstract: Formal Synthesis of Clavicipitic Acid Based on a Biosynthetic Proposal. Cheminform. 20. DOI: 10.1002/CHIN.198915204 |
0.092 |
|
| 1991 |
Markovich RJ, Qiu XX, Nichols DE, Pidgeon C, Invergo B, Alvarez FM. Silica subsurface amine effect on the chemical stability and chromatographic properties of end-capped immobilized artificial membrane surfaces. Analytical Chemistry. 63: 1851-60. PMID 1665020 DOI: 10.1021/Ac00017A034 |
0.084 |
|
| 2008 |
Aditya A, Nichols DE, Loudon GM. Borohydride reduction of estrone. Demonstration of diastereoselectivity in the undergraduateorganic chemistry laboratory Journal of Chemical Education. 85: 1535-1537. DOI: 10.1021/Ed085P1535 |
0.083 |
|
| 1999 |
Nichols DE, Frescas S. Improvements to the synthesis of psilocybin and a facile method for preparing the O-acetyl prodrug of psilocin Synthesis. 935-938. |
0.079 |
|
| 2010 |
Qandil AM, Miller DW, Nichols DE. ChemInform Abstract: A Practical and Cost-Effective Synthesis of 6,7-Dimethoxy-2-tetralone. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200011089 |
0.078 |
|
| 2021 |
Wilkinson V, Tokano K, Nichols D, Martin A, Holme R, Phalen D, Mounsey K, Charleston M, Kreiss A, Pye R, Browne E, Næsborg-Nielsen C, Richards SA, Carver S. Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use. Parasites & Vectors. 14: 18. PMID 33407820 DOI: 10.1186/s13071-020-04500-9 |
0.075 |
|
| 2015 |
Gaggar A, Chen J, Chmiel JF, Dorkin HL, Flume PA, Griffin R, Nichols D, Donaldson SH. Inhaled alpha1-proteinase inhibitor therapy in patients with cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 26321218 DOI: 10.1016/j.jcf.2015.07.009 |
0.074 |
|
| 2010 |
LEE S, FRESCAS SP, NICHOLS DE. ChemInform Abstract: A New, Simple Procedure for the Preparation of 8-Methoxy-2-tetralone. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199546114 |
0.069 |
|
| 1999 |
Qandil AM, Miller DW, Nichols DE. A practical and cost-effective synthesis of 6,7-dimethoxy-2-tetralone Synthesis. 2033-2035. |
0.069 |
|
| 2013 |
Nutt DJ, King LA, Nichols DE. Effects of Schedule I drug laws on neuroscience research and treatment innovation. Nature Reviews. Neuroscience. 14: 577-85. PMID 23756634 DOI: 10.1038/Nrn3530 |
0.069 |
|
| 1996 |
Ghosh D, Nichols DE. An improved method for the preparation of cyclic conjugated nitroolefins Synthesis. 195-197. |
0.068 |
|
| 1977 |
Nichols DE, Pfister WR, Yim GK, Cosgrove RJ. A new view of the structural relationship between LSD and mescaline. Brain Research Bulletin. 2: 169-71. PMID 890502 |
0.063 |
|
| 2018 |
Hoehn RD, Nichols DE, Neven H, Kais S. Status of the Vibrational Theory of Olfaction Frontiers in Physics. 6. DOI: 10.3389/Fphy.2018.00025 |
0.063 |
|
| 2016 |
Carhart-Harris RL, Muthukumaraswamy S, Roseman L, Kaelen M, Droog W, Murphy K, Tagliazucchi E, Schenberg EE, Nest T, Orban C, Leech R, Williams LT, Williams TM, Bolstridge M, Sessa B, ... ... Nichols D, et al. Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071089 DOI: 10.1073/Pnas.1518377113 |
0.062 |
|
| 1984 |
LLOYD DH, NICHOLS DE. ChemInform Abstract: A SIMPLE PROCEDURE FOR THE PREPARATION OF INDOLES Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198412202 |
0.062 |
|
| 2014 |
Seen A, Bizeau O, Sadler L, Jordan T, Nichols D. Assessment of Envi-Carb™ as a passive sampler binding phase for acid herbicides without pH adjustment. Chemosphere. 103: 306-12. PMID 24485816 DOI: 10.1016/j.chemosphere.2013.11.075 |
0.06 |
|
| 1972 |
BARFKNECHT CF, NICHOLS DE. ChemInform Abstract: EINFLUSS VON (S)-(+)- UND (R)-(-)-3,4-DIMETHOXYPHENYLISOPROPYLAMINEN (I) UND (II) BEI RATTEN Chemischer Informationsdienst. 3. DOI: 10.1002/CHIN.197219202 |
0.06 |
|
| 2016 |
Nichols DE. Psychedelics. Pharmacological Reviews. 68: 264-355. PMID 26841800 DOI: 10.1124/pr.115.011478 |
0.06 |
|
| 1982 |
Ferrigni NR, Putnam JE, Anderson B, Jacobsen LB, Nichols DE, Moore DS, McLaughlin JL, Powell RG, Smith CR. Modification and evaluation of the potato disc assay and antitumor screening of euphorbiaceae seeds. Journal of Natural Products. 45: 679-86. PMID 7161602 |
0.059 |
|
| 2010 |
STACHULSKI AV, NICHOLS DE, SCHEINMANN F. ChemInform Abstract: Stereochemical and NMR Reassignment of 6-Norlysergic Acid Diethylamide and 6-Nor-6-allyllysergic Acid Diethylamide. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199628264 |
0.051 |
|
| 2004 |
Bonner L, Frescas S, Nichols DE. A facile method for the preparation of pure cis-2,4-pentanediol Synthetic Communications. 34: 2767-2771. DOI: 10.1081/SCC-200026213 |
0.048 |
|
| 2011 |
Nichols D. Legal highs: the dark side of medicinal chemistry. Nature. 469: 7. PMID 21209630 DOI: 10.1038/469007a |
0.046 |
|
| 2020 |
Ney LJ, Felmingham KL, Nichols D. Reproducibility of saliva progesterone measured by immunoassay compared to liquid chromatography mass spectrometry. Analytical Biochemistry. 113984. PMID 33039429 DOI: 10.1016/j.ab.2020.113984 |
0.046 |
|
| 2019 |
Agrawal V, Fortune N, Yu S, Fuentes J, Shi F, Nichols D, Gleaves L, Poovey E, Wang TJ, Brittain EL, Collins S, West JD, Hemnes AR. Natriuretic peptide receptor C contributes to disproportionate right ventricular hypertrophy in a rodent model of obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension. Pulmonary Circulation. 9: 2045894019878599. PMID 31903184 DOI: 10.1177/2045894019895452 |
0.044 |
|
| 2021 |
Ney LJ, Matthews A, Nicholson E, Zuj D, Ken Hsu CM, Steward T, Graham B, Harrison B, Nichols D, Felmingham K. BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall. Behaviour Research and Therapy. 145: 103942. PMID 34340176 DOI: 10.1016/j.brat.2021.103942 |
0.044 |
|
| 1996 |
Stachulski AV, Nichols DE, Scheinmann F. Stereochemical and NMR Reassignment of 6-Norlysergic Acid Diethylamide and 6-Nor-6-allyllysergic Acid Diethylamide Journal of Chemical Research - Part S. 30-31. |
0.043 |
|
| 2021 |
Wilkinson V, Takano K, Nichols D, Martin A, Holme R, Phalen D, Mounsey K, Charleston M, Kreiss A, Pye R, Browne E, Næsborg-Nielsen C, Richards SA, Carver S. Correction to: Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use. Parasites & Vectors. 14: 140. PMID 33673849 DOI: 10.1186/s13071-021-04658-w |
0.043 |
|
| 2007 |
Nantachit N, Thaikruea L, Thongsawat S, Leetrakool N, Fongsatikul L, Sompan P, Fong YL, Nichols D, Ziermann R, Ness P, Nelson KE. Evaluation of a multiplex human immunodeficiency virus-1, hepatitis C virus, and hepatitis B virus nucleic acid testing assay to detect viremic blood donors in northern Thailand. Transfusion. 47: 1803-8. PMID 17880604 DOI: 10.1111/J.1537-2995.2007.01395.X |
0.043 |
|
| 1982 |
Meyer BN, Ferrigni NR, Putnam JE, Jacobsen LB, Nichols DE, McLaughlin JL. Brine shrimp: a convenient general bioassay for active plant constituents. Planta Medica. 45: 31-4. PMID 7100305 |
0.043 |
|
| 2024 |
O'Donohue MP, Amir Hamzah K, Nichols D, Ney LJ. Trauma film viewing and intrusive memories: Relationship between salivary alpha amylase, endocannabinoids, and cortisol. Psychoneuroendocrinology. 164: 107007. PMID 38503195 DOI: 10.1016/j.psyneuen.2024.107007 |
0.042 |
|
| 2013 |
Nichols DE, Fantegrossi WE. Emerging Designer Drugs The Effects of Drug Abuse On the Human Nervous System. 575-596. DOI: 10.1016/B978-0-12-418679-8.00019-8 |
0.041 |
|
| 2011 |
Fenizia C, Keele BF, Nichols D, Cornara S, Binello N, Vaccari M, Pegu P, Robert-Guroff M, Ma ZM, Miller CJ, Venzon D, Hirsch V, Franchini G. TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposure. Journal of Virology. 85: 12399-409. PMID 21917950 DOI: 10.1128/Jvi.05707-11 |
0.041 |
|
| 2012 |
Raines J, Snow R, Petersen A, Harvey J, Nichols D, Aisbett B. Pre-shift fluid intake: effect on physiology, work and drinking during emergency wildfire fighting. Applied Ergonomics. 43: 532-40. PMID 21906723 DOI: 10.1016/j.apergo.2011.08.007 |
0.039 |
|
| 2018 |
Mtibaa K, Thomson A, Nichols D, Hautier C, Racinais S. Hyperthermia-induced Neural Alterations Impair Proprioception and Balance. Medicine and Science in Sports and Exercise. 50: 46-53. PMID 28863075 DOI: 10.1249/MSS.0000000000001418 |
0.039 |
|
| 2023 |
King LA, Nutt DJ, Nichols DE. Remove barriers to clinical research for schedule 1 drugs with therapeutic potential. Bmj (Clinical Research Ed.). 381: p981. PMID 37130596 DOI: 10.1136/bmj.p981 |
0.037 |
|
| 2007 |
Rocha-Sanchez SM, Morris KA, Kachar B, Nichols D, Fritzsch B, Beisel KW. Developmental expression of Kcnq4 in vestibular neurons and neurosensory epithelia. Brain Research. 1139: 117-25. PMID 17292869 DOI: 10.1016/J.Brainres.2006.12.087 |
0.037 |
|
| 2018 |
Nichols DE, Grob CS. Is LSD toxic? Forensic Science International. 284: 141-145. PMID 29408722 DOI: 10.1016/j.forsciint.2018.01.006 |
0.036 |
|
| 2021 |
Stone C, Ney L, Felmingham K, Nichols D, Matthews A. The effects of acute stress on attentional networks and working memory in females. Physiology & Behavior. 113602. PMID 34555409 DOI: 10.1016/j.physbeh.2021.113602 |
0.036 |
|
| 2013 |
Raines J, Snow R, Petersen A, Harvey J, Nichols D, Aisbett B. The effect of prescribed fluid consumption on physiology and work behavior of wildfire fighters. Applied Ergonomics. 44: 404-13. PMID 23149116 DOI: 10.1016/j.apergo.2012.10.002 |
0.035 |
|
| 2013 |
Nutt DJ, King LA, Nichols DE. New victims of current drug laws. Nature Reviews. Neuroscience. 14: 877. PMID 24149187 DOI: 10.1038/Nrn3530-C2 |
0.034 |
|
| 2013 |
Netto K, Lord C, Petersen A, Janssen J, Nichols D, Aisbett B. Muscle activation during the Pack Hike test and a critical wildfire fighting task. Applied Ergonomics. 44: 274-7. PMID 22981470 DOI: 10.1016/j.apergo.2012.08.003 |
0.034 |
|
| 2023 |
Nichols D, Gifford A, Russell R, Odem-Davis K, Young J, Amaro-Galvez R, Billings J, Mukadam Z, Mayer-Hamblett N. Assessing Safety of Discontinuing Hypertonic Saline in Those with Lower FEV1 after Elexacaftor/Tezacaftor/Ivacaftor. Annals of the American Thoracic Society. PMID 38019099 DOI: 10.1513/AnnalsATS.202308-735RL |
0.033 |
|
| 2021 |
Ney L, Stone C, Nichols D, Felmingham K, Bruno R, Matthews A. Endocannabinoid reactivity to acute stress: Investigation of the relationship between salivary and plasma levels. Biological Psychology. 159: 108022. PMID 33460783 DOI: 10.1016/j.biopsycho.2021.108022 |
0.033 |
|
| 2022 |
Blackburn JB, Schaff JA, Gutor S, Du RH, Nichols D, Sherrill T, Gutierrez AJ, Xin MK, Wickersham N, Zhang Y, Holtzman MJ, Ware LB, Banovich NE, Kropski JA, Blackwell TS, et al. Secretory Cells are the Primary Source of pIgR in Small Airways. American Journal of Respiratory Cell and Molecular Biology. PMID 35687143 DOI: 10.1165/rcmb.2021-0548OC |
0.032 |
|
| 2021 |
Negretti NM, Plosa EJ, Benjamin JT, Schuler BA, Habermann AC, Jetter CS, Gulleman P, Bunn C, Hackett AN, Ransom M, Taylor CJ, Nichols D, Matlock BK, Guttentag SH, Blackwell TS, et al. A single-cell atlas of mouse lung development. Development (Cambridge, England). 148. PMID 34927678 DOI: 10.1242/dev.199512 |
0.032 |
|
| 2003 |
Parenteau CS, Viano DC, Shah M, Gopal M, Davies J, Nichols D, Broden J. Field relevance of a suite of rollover tests to real-world crashes and injuries. Accident; Analysis and Prevention. 35: 103-10. PMID 12479901 DOI: 10.1016/S0001-4575(01)00094-X |
0.029 |
|
| 1990 |
Smith MC, Nichols D, Wensyel JW. The Administration of Public Safety in Higher Education. The Journal of Higher Education. 61: 115. DOI: 10.2307/1982041 |
0.029 |
|
| 2023 |
Périard JD, Girard O, Townsend N, Bourdon P, Cocking S, Ihsan M, Lacome M, Nichols D, Travers G, Wilson MG, Piscione J, Racinais S. Hematological Adaptations Following a Training Camp in Hot and/or Hypoxic Conditions in Elite Rugby Union Players. International Journal of Sports Physiology and Performance. 1-9. PMID 37553108 DOI: 10.1123/ijspp.2023-0166 |
0.028 |
|
| 2020 |
Travers G, González-Alonso J, Riding NR, Nichols D, Shaw A, Periard JD. Exercise heat acclimation has minimal effects on left ventricular volumes, function and systemic hemodynamics in euhydrated and dehydrated trained humans. American Journal of Physiology. Heart and Circulatory Physiology. PMID 32886001 DOI: 10.1152/ajpheart.00466.2020 |
0.027 |
|
| 2012 |
Lord C, Netto K, Petersen A, Nichols D, Drain J, Phillips M, Aisbett B. Validating 'fit for duty' tests for Australian volunteer fire fighters suppressing bushfires. Applied Ergonomics. 43: 191-7. PMID 21714952 DOI: 10.1016/j.apergo.2011.05.003 |
0.025 |
|
| 1979 |
Yim GK, Prah TE, Pfister WR, Nichols DE. An economical screen for phenethylamine-type hallucinogens: mouse ear scratching. Communications in Psychopharmacology. 3: 173-8. PMID 574070 |
0.025 |
|
| 2010 |
Petersen A, Payne W, Phillips M, Netto K, Nichols D, Aisbett B. Validity and relevance of the pack hike wildland firefighter work capacity test: a review. Ergonomics. 53: 1276-85. PMID 20865610 DOI: 10.1080/00140139.2010.513451 |
0.025 |
|
| 2018 |
Nichols DE. Author's reply. Journal of Psychopharmacology (Oxford, England). 32: 821-822. PMID 29991342 DOI: 10.1177/0269881118767648a |
0.025 |
|
| 2017 |
Cocking S, Wilson MG, Nichols D, Cable NT, Green DJ, Thijssen DHJ, Jones H. Is There an Optimal Ischaemic Preconditioning Dose to Improve Cycling Performance? International Journal of Sports Physiology and Performance. 1-25. PMID 28657799 DOI: 10.1123/ijspp.2017-0114 |
0.024 |
|
| 2021 |
Travers G, González-Alonso J, Riding N, Nichols D, Shaw A, Périard JD. Exercise Heat Acclimation With Dehydration Does Not Affect Vascular and Cardiac Volumes or Systemic Hemodynamics During Endurance Exercise. Frontiers in Physiology. 12: 740121. PMID 34867447 DOI: 10.3389/fphys.2021.740121 |
0.022 |
|
| 2008 |
Nichols D, Chmiel J, Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clinical Reviews in Allergy & Immunology. 34: 146-62. PMID 17960347 DOI: 10.1007/S12016-007-8039-9 |
0.022 |
|
| 1995 |
Nichols DE. Psychedelics article was excellent; a clarification is necessary. Alternative Therapies in Health and Medicine. 1: 13. PMID 9359789 |
0.022 |
|
| 2023 |
Cheng TL, Unaka NI, Nichols D. Crossing the Quality Chasm and the Ignored Pillar of Health Care Equity. Pediatric Clinics of North America. 70: 855-861. PMID 37422318 DOI: 10.1016/j.pcl.2023.03.013 |
0.021 |
|
| 2024 |
Duong JT, Pope CE, Hayden HS, Miller C, Salipante SJ, Rowe SM, Solomon GM, Nichols D, Hoffman LR, Narkewicz MR, Green N. Alterations in the fecal microbiota in patients with advanced cystic fibrosis liver disease after 6 months of elexacaftor/tezacaftor/ivacaftor. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 38448281 DOI: 10.1016/j.jcf.2024.02.015 |
0.021 |
|
| 2021 |
Racinais S, Périard JD, Piscione J, Bourdon PC, Cocking S, Ihsan M, Lacome M, Nichols D, Townsend N, Travers G, Wilson MG, Girard O. Intensified Training Supersedes the Impact of Heat and/or Altitude for Increasing Performance in Elite Rugby Union Players. International Journal of Sports Physiology and Performance. 1-8. PMID 33668015 DOI: 10.1123/ijspp.2020-0630 |
0.02 |
|
| 2016 |
Rowe JR, Biggerstaff KD, Ben-Ezra V, Nichols D, DiMarco N. Prior Exercise Does Not Reduce Postprandial Lipemia Following a Mixed Glucose Meal When Compared to a Mixed Fructose Meal. International Journal of Sport Nutrition and Exercise Metabolism. PMID 27096428 DOI: 10.1123/Ijsnem.2015-0274 |
0.019 |
|
| 2016 |
Greenwald S, Seger E, Nichols D, Ray AD, Rideout TC, Gosselin LE. Effect of an Acute Bout of Kettlebell Exercise on Glucose Tolerance in Sedentary Men: A Preliminary Study. International Journal of Exercise Science. 9: 524-535. PMID 27766136 |
0.018 |
|
| 2021 |
Ney LJ, Matthews A, Hsu CK, Zuj DV, Nicholson E, Steward T, Nichols D, Graham B, Harrison B, Bruno R, Felmingham K. Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning. Depression and Anxiety. PMID 34151472 DOI: 10.1002/da.23170 |
0.016 |
|
| 2002 |
Nichols D. Who was ..... Percy Sladen? Biologist. 49: 227-228. PMID 12391415 |
0.015 |
|
| 2013 |
Miller J, Nichols D. Moving among friends: the establishment of professional social work education at the University of Melbourne, 1929-1941. Social Work in Health Care. 52: 110-24. PMID 23521380 DOI: 10.1080/00981389.2012.737905 |
0.015 |
|
| 2020 |
Benjamin JT, Plosa E, Sucre J, van der Meer R, Dave S, Gutor SS, Nichols D, Gulleman P, Jetter C, Han W, Xin MK, Dinella PC, Catanzarite A, Kook S, Dolma K, et al. Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD. The Journal of Clinical Investigation. PMID 33108351 DOI: 10.1172/JCI139481 |
0.015 |
|
| 2012 |
Phillips M, Payne W, Lord C, Netto K, Nichols D, Aisbett B. Identification of physically demanding tasks performed during bushfire suppression by Australian rural firefighters. Applied Ergonomics. 43: 435-41. PMID 21802652 DOI: 10.1016/j.apergo.2011.06.018 |
0.014 |
|
| 2007 |
Aisbett B, Phillips M, Sargeant M, Gilbert B, Nichols D. Fighting with fire--how bushfire suppression can impact on fire fighters' health. Australian Family Physician. 36: 994-7. PMID 18075620 |
0.014 |
|
| 2020 |
Racinais S, Nichols D, Travers G, Moussay S, Belfekih T, Farooq A, Schumacher YO, Périard JD. Health status, heat preparation strategies and medical events among elite cyclists who competed in the heat at the 2016 UCI Road World Cycling Championships in Qatar. British Journal of Sports Medicine. PMID 31992546 DOI: 10.1136/bjsports-2019-100781 |
0.014 |
|
| 1972 |
Altan T, Nichols DE. Use of Standardized Copper Cylinders for Determining Load and Energy in Forging Equipment Journal of Engineering For Industry. 94: 769-774. DOI: 10.1115/1.3428249 |
0.014 |
|
| 1983 |
Holsapple MP, Trizzino J, Nichols DE, Yim GK. Therapeutic and adjunctive applications of an imidazoline anti-inflammatory agent. The Journal of Pharmacology and Experimental Therapeutics. 224: 567-71. PMID 6827479 |
0.013 |
|
| 2020 |
Travers G, Nichols D, Riding N, González-Alonso J, Périard JD. Heat Acclimation with Controlled Heart Rate: Influence of Hydration Status. Medicine and Science in Sports and Exercise. PMID 32102056 DOI: 10.1249/MSS.0000000000002320 |
0.011 |
|
| 1994 |
Pfaff RC, Huang X, Marona-Lewicka D, Oberlender R, Nichols DE. Lysergamides revisited. Nida Research Monograph. 146: 52-73. PMID 8742794 |
0.01 |
|
| 2020 |
Nichols DE, Walter H. The History of Psychedelics in Psychiatry. Pharmacopsychiatry. PMID 33285579 DOI: 10.1055/a-1310-3990 |
0.01 |
|
| 2020 |
Nichols DE. Psilocybin: from ancient magic to modern medicine. The Journal of Antibiotics. PMID 32398764 DOI: 10.1038/s41429-020-0311-8 |
0.01 |
|
| 2019 |
Kolankiewicz V, Nichols D, Freestone R. The tribulations of Walter Burley Griffin’s final Australian plan: Milleara as ‘the garden city of the future’ 1925–1965 Planning Perspectives. 34: 911-923. DOI: 10.1080/02665433.2019.1642237 |
0.01 |
|
| 2018 |
Racinais S, Moussay S, Nichols D, Travers G, Belfekih T, Schumacher YO, Periard JD. Core temperature up to 41.5ºC during the UCI Road Cycling World Championships in the heat. British Journal of Sports Medicine. PMID 30504486 DOI: 10.1136/bjsports-2018-099881 |
0.01 |
|
| 2018 |
Nichols D. Case of congenital nystagmus. Journal of Paediatrics and Child Health. PMID 30242942 DOI: 10.1111/jpc.14161 |
0.01 |
|
| 2017 |
Nichols DE, Grob CS, Greer GR. Addressing the need for rigor in the rebirth of hallucinogen research Drug and Alcohol Dependence. 170: 208. DOI: 10.1016/j.drugalcdep.2016.10.010 |
0.01 |
|
| 2016 |
Pan CC, Davis R, Nichols D, Hwang SH, Hsieh K. Prevalence of overweight and obesity among students with intellectual disabilities in Taiwan: A secondary analysis. Research in Developmental Disabilities. 53: 305-313. PMID 26986697 DOI: 10.1016/j.ridd.2016.02.018 |
0.01 |
|
| 2015 |
Raines J, Snow R, Nichols D, Aisbett B. Fluid intake, hydration, work physiology of wildfire fighters working in the heat over consecutive days. The Annals of Occupational Hygiene. 59: 554-65. PMID 25667157 DOI: 10.1093/annhyg/meu113 |
0.01 |
|
| 2014 |
Watson P, Nichols D, Cordery P. Mouth rinsing with a carbohydrate solution does not influence cycle time trial performance in the heat. Applied Physiology, Nutrition, and Metabolism = Physiologie AppliquéE, Nutrition Et MéTabolisme. 39: 1064-9. PMID 25154896 DOI: 10.1139/apnm-2013-0413 |
0.01 |
|
| 2014 |
Wolkow A, Netto K, Langridge P, Green J, Nichols D, Sergeant M, Aisbett B. Coronary heart disease risk in volunteer firefighters in Victoria, Australia. Archives of Environmental & Occupational Health. 69: 112-20. PMID 24205963 DOI: 10.1080/19338244.2012.750588 |
0.01 |
|
| 2010 |
Thomas P, Goodspeed E, Nichols D. Johns Hopkins University School of Medicine. Academic Medicine : Journal of the Association of American Medical Colleges. 85: S253-8. PMID 20736561 DOI: 10.1097/ACM.0b013e3181e8de6d |
0.01 |
|
| 2010 |
Davis R, Sanborn C, Nichols D, Bazett-Jones DM, Dugan EL. The effects of whole body vibration on bone mineral density for a person with a spinal cord injury: a case study. Adapted Physical Activity Quarterly : Apaq. 27: 60-72. PMID 20147770 |
0.01 |
|
| 2009 |
Nichols D. Civilized executions. Journal of the Royal Society of Medicine. 102: 506. PMID 19966120 DOI: 10.1258/jrsm.2009.090410 |
0.01 |
|
| 2008 |
Ford L, Harper D, Kapustin J, Nichols D, Norris TE. NPs and MDs: an evolving partnership. Interview by Sarah Lebo. Advance For Nurse Practitioners. 16: 55-9. PMID 19181143 |
0.01 |
|
| 2006 |
Nichols D. LSD: Cultural revolution and medical advances Chemistry World. 3: 30-34. |
0.01 |
|
| 2005 |
Nichols D. Wrongful diagnosis of child abuse. Journal of the Royal Society of Medicine. 98: 386-7. PMID 16055910 DOI: 10.1258/jrsm.98.8.386-b |
0.01 |
|
| 1998 |
Delgadillo LA, Nichols DE. Oat cell carcinoma metastasis to the foot. The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons. 37: 55-62. PMID 9470118 |
0.01 |
|
| 1996 |
Nichols DE. Maximum energy traveltimes calculated in the seismic frequency band Geophysics. 61: 253-262. |
0.01 |
|
| 1991 |
Nichols DE, Nguyen DT, Burnell JR, Dillard EF. Corrosion of carbon steel and 18% Cr-8% Ni stainless steels in 23% by weight fluorosilicic acid and 10-30-0 suspension fertilizer with fluorosilicic acid added Fertilizer Research. 29: 335-346. DOI: 10.1007/BF01052403 |
0.01 |
|
| 1962 |
Brenan JPM, Nichols D. Taxonomy and Geography The Geographical Journal. 128: 548. DOI: 10.2307/1792104 |
0.01 |
|
| 1960 |
NICHOLS D. Russian-English Glossary of Hydrobiology Limnology and Oceanography. 5: 242-243. DOI: 10.4319/LO.1960.5.2.0242 |
0.01 |
|
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