Charles Ksir - US grants

Affiliations:

University of Wyoming, Laramie, WY, United States

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High-probability grants

According to our matching algorithm, Charles Ksir is the likely recipient of the following grants.

Years	Recipients	Code	Title / Keywords	Matching score
1987 — 1992	Ksir, Charles	S07Activity Code Description: To strengthen, balance, and stabilize Public Health Service supported biomedical and behavioral research programs at qualifying institutions through flexible funds, awarded on a formula basis, that permit grantee institutions to respond quickly and effectively to emerging needs and opportunities, to enhance creativity and innovation, to support pilot studies, and to improve research resources, both physical and human.	Biomedical Research Support @ University of Wyoming health science research support; university; Show keywords Hide keywords	1
1987	Ksir, Charles	S15Activity Code Description: Undocumented code - click on the grant title for more information.	Rotary Microtome and 1/2-Inch Tape Drive @ University of Wyoming biomedical equipment resource; Show keywords Hide keywords	1
1988 — 1989	Ksir, Charles	S15Activity Code Description: Undocumented code - click on the grant title for more information.	Small Instrumentation Program @ University of Wyoming biomedical equipment resource; biomedical equipment purchase; Show keywords Hide keywords	1
1989 — 1991	Ksir, Charles	R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.	Behavioral Neuropharmacology of Nicotine @ University of Wyoming Repeated exposure to low doses of nicotine produces increased responsiveness to the stimulatory effects of nicotine and prolonged elevations in the number of nicotine receptors in the brain. These phenomena are likely to be important aspects of the process of developing and maintaining a dependence on nicotine. This project will use several experimental approaches to further our understanding of nicotine as a behavioral stimulant and as a drug of dependence. One series of studies will employ lesion, pharmacological blockade, and localized intracerebral microinfusions to test the hypothesis that nicotine exerts its stimulant actions in rats through the mesolimbic dopamine pathway. This pathway has been widely studied as a neural substrate for the stimulant actions of amphetamine, cocaine, and the opiates. We will also train rats to self-administer nicotine, to determine whether previous experience with nicotine increases the reinforcing properties of the first self-administered doses. Our previous research demonstrates that rats allowed to drink nicotine solutions will increase their intake over days and show altered behavioral reactions to orally infused nicotine solutions (increased ingestive behaviors). Several experiments usinq two-bottle preference tests and taste reactivity to oral infusions will test whether the increased intake seen with experience is related to the reinforcing properties of the ingested nicotine or to a diminished aversive reaction to the sensory properties of the solutions. Understanding the behavioral neuropharmacoloqy of nicotine dependence is important for two reasons. First, tobacco dependence is responsible for more American deaths each year than all other forms of drug dependence combined. Second, both the brain systems under investigation and the techniques to be employed are of importance for understanding other drugs of abuse. Show summary Hide summary	1
1990 — 1993	Ksir, Charles	S15Activity Code Description: Undocumented code - click on the grant title for more information.	Small Instrumentation Grant @ University of Wyoming biomedical equipment purchase; Show keywords Hide keywords	1
1994	Ksir, Charles J	S15Activity Code Description: Undocumented code - click on the grant title for more information.	Title Omitted @ University of Wyoming biomedical equipment purchase; Show keywords Hide keywords	0.958