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High-probability grants
According to our matching algorithm, Deda Gillespie is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2003 |
Gillespie, Deda C |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Glutamate in Development of Inhibitory Auditory Pathway @ University of Pittsburgh At Pittsburgh
DESCRIPTION (provided by applicant): This project aims to increase our understanding of inhibitory development in the auditory brainstem. Evidence suggests that the nominally inhibitory projection from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) uses the excitatory neurotransmitter glutamate during early postnatal life. This further suggests that glutamate could mediate inhibitory synaptic plasticity, if co-released with GABA/glycine at individual MNTB-LSO synapses. Experiments will use electrophysiological and immunohistochemical approaches to test the hypothesis that glutamate and GABA/glycine are co-released at individual GABA/glycinergic MNTB-LSO synapses. Whole-cell patch clamp recordings in brainstem slices, together with pharmacological and minimal stimulation techniques and paired-pulse analysis, will be used to test for corelease. Double and triple immunofluorescent labeling for vesicular transporters of glutamate and GABA/glycine, together with confocal microscopy and colocalization analysis, will be used to determine whether glutamate and GABA/glycine colocalize. This will indicate whether glutamate release could accompany GABA/glycine release at the same terminal or whether it defines a functionally distinct, hitherto undescribed, glutamatergic sub-population of MNTB neurons. Conclusions from these experiments will augment our understanding of the cellular events that govern auditory brainstem development. If the study points to a fundamental mechanistic role for glutamate release, results could potentially shed light on inhibitory development generally and advance our understanding of brain disorders caused by abnormal inhibition, such as epilepsy.
|
0.911 |
2005 |
Gillespie, Deda C |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Glutamate in Development of Auditory Brainstem @ University of Pittsburgh At Pittsburgh
DESCRIPTION (provided by applicant): The lateral superior olive (LSO), a binaural nucleus involved in sound localization, receives converging excitatory and inhibitory projections that are precisely tonotopically matched. The inhibitory projection from the MNTB is refined early in postnatal life through mechanisms that are largely unknown. It was recently found that inhibitory neurons in the MNTB-LSO projection release glutamate during the period of synaptic refinement. The vesicular glutamate transporter VGLUT3, which could support this glutamate release, is transiently expressed in the LSO during the same period and is downregulated shortly after hearing onset. This project will test the hypothesis that VGLUT3 expression in the LSO is downregulated by specific auditory experience. It also aims to test the hypothesis that different vesicular glutamate transporters specifically label the excitatory and inhibitory projections during development. The early glutamatergic transmission in the MNTB-LSO pathway is mediated in large part by postsynaptic NMDA receptors. NMDA receptors have known roles in synaptic plasticity in many systems, with different NMDA receptor subtypes playing distinct roles. Thus, an understanding of the particular NMDA receptor subtypes involved, and whether glutamate is likely to be co-released with GABA and glycine, will be necessary for further studies of glutamate's role in development of the LSO. The third arm of this proposal is to characterize basic physiology of glutamate transmission in both excitatory and inhibitory pathways, as a framework for further studies on the coordinated development of inhibitory and excitatory synapses. Conclusions from these studies will provide insight into the development of a major auditory nucleus, and may ramify beyond the auditory system to shed light on brain disorders involving abnormal inhibition, such as epilepsy and autism.
|
0.911 |