Nathan A. Vandergrift, Ph.D. - US grants

Affiliations:

2004

University of North Carolina, Chapel Hill, Chapel Hill, NC

Area:

Psychometrics Psychology

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High-probability grants

According to our matching algorithm, Nathan A. Vandergrift is the likely recipient of the following grants.

Years	Recipients	Code	Title / Keywords	Matching score
2002 — 2003	Vandergrift, Nathan A	F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.).	Modeling Nonlinear Trajectories: a Review and Simulation @ University of North Carolina Chapel Hill DESCRIPTION (provided by applicant): Longitudinal data with a nonlinear functional form is ubiquitous in the behavioral sciences. In studies of substance abuse, trajectories of drug use over time are distinctly nonlinear. It is paramount that the nonlinearity be properly modeled. If it is not, researchers run the risk of drawing biased or misleading conclusions from an incorrect model. The proposed project will unify the disparate literature on longitudinal modeling of trajectories with nonlinear functional forms. Following a unification of the literature analytic comparisons will be made between the different methods of modeling nonlinearity. The analytic comparisons will generate testable hypotheses for an empirical evaluation of the methods in a simulation study. The proposal is organized around three specific aims. Aim 1 is to review and organize the literature in order to have an up-to-date representation of the available methods. Aim 2 is to analytically evaluate and compare the methods described by Aim 1. Aim 3 will evaluate hypotheses generated from Aim 2 in a simulation study that will empirically evaluate the performance of the different methods under four conditions: alternative functional forms of the underlying data; a range of sample size; the number of occasions of measurement; finally, the magnitude of the random effect in the parameters of the models will range from small to relatively large. It is hoped that the proposed project will make a valuable and unique contribution to the field by providing behavioral scientists with guidance for utilizing these methods and methodological researchers with directions for future extensions and research. Show summary Hide summary	1
2016 — 2020	Vandergrift, Nathan A	P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal.	Analytical Resources Core @ Duke University ABSTRACT: Core 2. Analytical Resources Core The Analytical Resources Core (Core 2) will contribute to the overall Program goals and to each Project by exploring the specific hypothesis that the structural and biophysical/chemical features of antibody recognition will define mechanisms associated with potent or weak effector function and similarities and differences in antibody biology between species relevant to vaccine and antibody therapy outcomes. The Core will provide key services for biophysical, biochemical, and structural characterization of Ab interactions, complemented by central analysis of data collected through Projects 1, 2, and 3, for synthesis to define key similarities and differences between NHP and humans in terms of Ab and effector cell biology. The specific aims of this core are as follows: AIM 1. Determine and optimize FcR binding profiles of Program antibodies and immune complexes. AIM 2. Determine co-crystal structures of relevant Program Ab:antigen and Ab:Fc receptor pairs. AIM 3. Model the knowledge of paratope and Fc function to define optimal antibody features for Fc- mediated antiviral activities. Through these aims, this Core will serve the needs of all three Projects and provide key contributions to achieving the shared goals of this Program. Show summary Hide summary	0.97