Kristen A. Lindquist, PhD - US grants

How can we know how other people are really feeling? If emotions are intensely experienced it may be easy to tell, but some people are good at hiding their emotions, or they may be unaware of or unable to report what they are feeling. Fortunately, technological advances in measuring brain activity and emotion theory can help us to have a more objective understanding of people's emotional states. Some theories of emotion suggest that different emotional states, such as fear, anger, or happiness, arise because of specific, dedicated neural circuitry that responds in the same way any time that emotion is experienced. For example, the circuitry for happiness is the same whether it arises because you get a compliment or you learned of a promotion. In contrast, the proposed research is built on an innovative 'situated neuroscience' model of emotions. This model hypothesizes that emotions correspond to variable neural patterns. These variable patterns are hypothesized to be determined by the emotion category experienced, such as fear, and partly by the context in which the emotion is experienced. The context includes components from culture and the situation itself. Dr. Kristen Lindquist, at the University of North Carolina at Chapel Hill, and colleagues proposed three experiments to examine this model. Her research will use measures of the location of brain events (functional magnetic resonance imaging; fMRI) and the timing of brain events (electroencephalography; EEG). The integration of emotion theory and technology in this way could help to improve communication about and understanding of emotions, help us to predict when emotions influence our decisions and performance, and may have benefits for the way we interact with others.

The proposed research integrates emotion theory with technological advances in measuring brain activity to "read" emotional feelings from brain states. The aim is to develop a situated neuroscience of emotion that will inform our understanding of the basis of emotions and their conscious experience. Three experiments are proposed that examine the role of situational and cultural contexts in emotion and brain activity. The first experiment examines fear and anger and their interaction with situational and cultural contexts on brain activity, using functional magnetic resonance (fMRI). The situation is manipulated to be either social or non-social, and culture stems from enrolling natives of the US and China who know the emotion-based norms and values of their respective culture. The second experiment extends this investigation to the temporal dynamics of emotional brain activity using electroencephalography (EEG). The third study uses machine learning on data obtained from the prior experiments to determine which variables best predict brain activity during emotion, in the different contexts. Understanding the situated nature of emotion is crucial to an understanding of how neural circuits map on to subjective mental states. These findings may improve our understanding of emotional experience in ourselves and others, and enhance our communication, well-being, and diplomatic relations. It may also inform applied advancements in the areas of mood-related illnesses and brain-computer interface.

Project Summary/Abstract An alarming number of adolescents will engage in substance use (including alcohol, tobacco, marijuana and opioids) before they leave high school, a fact that has serious long-term health and societal impacts. Since most adolescents begin using substances with peers, an understanding of the processes that lead to peer influence susceptibility in the context of substance-using peers offers critical avenues for successful intervention in substance use. Our prior research developed a unique performance-based experimental paradigm for measuring peer influence susceptibility and found that individual differences in susceptibility interact with adolescents? perceptions of their peers? substance use to predict their own substance use engagement. However, it remains unclear why some adolescents are more susceptible to peer influence than others, and how development confers increased risk for susceptibility. This work will examine the neural correlates associated with individual differences in peer influence susceptibility. Specifically, we will assess how increased functional connectivity within and between neural networks subserving greater sensitivity to social rewards and punishments, motivation to attain rewards and avoid punishment, and representations of social others is associated with greater peer influence susceptibility. We will also examine a network involved in executive control as a protective factor against later substance use. Using a two-cohort, accelerated longitudinal design including adolescents spanning grades 6-12, we will investigate how individual differences in connectivity within and between candidate neural networks predict prospective substance use initiation in the context of peers. Eight hundred adolescents (age 11-13 years) will complete baseline assessments of substance use, and peer influence susceptibility using an innovative experimental paradigm. A subset (n = 250) of the initial sample will partake in longitudinal task-based functional imaging in year 1 and 3, as well as multi-wave longitudinal assessment occurring at one-year longitudinal intervals in subsequent years 2-5 to obtain extensive data on adolescents? and peers? substance use trajectories across a critical developmental period associated with substance use. By delineating the neurobiological markers of social influence susceptibility, project findings can characterize those individuals at greatest risk for substance use, which can inform interventions by targeting the psychological processes that contribute to peer influence susceptibility.