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High-probability grants
According to our matching algorithm, Nancy R. Cox is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 1994 |
Cox, Nancy |
R15Activity Code Description:
Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Gangliosides and Thymic Development @ Auburn University At Auburn
Premature thymic involution with preferential loss of immune CD4+ CD8+ thymocytes involving augmented apoptotic mechanisms occurs in cats affected with GMI and GM2 gangliosidosis. The proposed studies will define the role of ganglioside in the molecular processes of apoptotic cell death in the thymus by evaluating the effects of excess ganglioside in vivo and in vitro on apoptotic induction events involving receptors, transmembrane signal transduction and second messenger systems. Specific metabolic events to be evaluated include: tyrosine phosphorylation, phospholipase C activity, in transcellular calcium homeostasis, calcium mediated events, calmodulin/calcineurin associated events, proteins kinase C activity and cyclic nucleotide concentration. To accomplish these goals, we will study organs and cells derived from cats affected with gangliosidoses and well-defined in vitro model systems based on incorporation of exogenous ganglioside into thymocyte and fetal thymic organ culture. These studies are unique because for the first time it is possible to study ganglioside induced premature thymic involution and accelerated thymocyte apoptosis in a naturally occurring animal disease and results of these studies can be contrasted and compared with in vitro models based on exogenous incorporated ganglioside. These studies will provide new information about ganglioside modulation of thymocyte development, the role of ganglioside in apoptosis, and immune system dysfunction in lysosomal storage diseases.
|
0.903 |
| 2003 — 2005 |
Cox, Nancy |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Feline Stem Cells: Isolation, Characterization and Fat @ Auburn University At Auburn
DESCRIPTION (Provided by applicant):Recent studies, in humans and other animal species, indicate that marrow stromal cells (MSC) are multipotent and have potential use in treatment of disease. The development of a non-rodent, non-inbred large animal model system is critical to fully understand the biological mechanisms involved and to explore potential use of such cells in disease therapies for humans. Cats are uniquely suited for basic research of biologic and disease processes, particularly in developmental biology, normal physiology, and animal modeling of human inherited, infectious and neoplastic diseases. The goal of this project is to develop feline marrow stromal stem cell model systems that can then be used to study safety and efficacy of stem cell transplantation therapy. Protocols will be developed for optimal isolation and expansion of MSC from bone marrow of normal cats. Methods will be optimized to separate these multipotential progenitor cells from other cells in bone marrow. Media components, seeding densities and growth factor effects on short term and long term passage in vitro will be evaluated. Optimal age of donor cats also will be investigated. A comprehensive characterization of feline MSC in vitro based on markers of gene expression and on peptide affinity technology will be accomplished. The potential of feline MSC to differentiate to various cell phenotypes based on media manipulation will be explored. The distribution and fate of feline MSC following in vivo transplantation will be studied. Feline MSC will be harvested, labeled with a reporter gene, injected by several routes back into the same individual, and analyzed at various time points to track these cells in different organs. Similar trafficking studies will be done with cells phenotypically differentiated in vitro to determine their fates.
|
0.903 |