D. Lynn Loriaux - US grants
Affiliations: | Developmental Endocrinology | National Institutes of Health, Bethesda, MD |
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, D. Lynn Loriaux is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 1993 — 1997 | Loriaux, D Lynn | T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Training Grant in Endocrinology, Diabetes, Nutrition @ Oregon Health and Science University |
0.923 |
| 1994 — 1998 | Loriaux, D Lynn | P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
Stress, the H-P-a Axis, and Growth and Development @ Oregon Health and Science University Stress can be defined as an environmental transient challenging homeostasis. Most organisms have developed "stress responses" that buffer the stress or attenuate its effects. Examples include the sporulation of bacteria and the estivation of amphibians. Perhaps the best known and least understood stress response in mammals is activation of the hypothalamic-pituitary-adrenal (HPA) axis. The mechanism by which the hypothalamus stimulates the pituitary POMC cells to secrete ACTH and other POMC products, the role of these products, and the role of the consequent adrenal glucocorticoids in responding to stress is poorly understood. This program project has three objectives. The first objective is to better understand the array of hypothalamic hormones regulating the pituitary POMC cell and the biochemical mechanisms by which this regulation occurs. The second objective is to better understand the stress related biologic effects of the specific molecular elements of the HPA response to stress. The third objective is to more precisely characterize the HPA response to stress in the human being and to define its role in several "stress associated" disorders of growth and development. To accomplish these objectives we have developed five interacting projects using five shared facilities. The shared facilities include tissue culture, radioimmunoassay, transgenic mouse, histochemistry and administrative "cores". |
0.923 |
| 1994 — 1998 | Loriaux, D Lynn | P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
Stress--Adverse Effects On Humans and Growth and Development @ Oregon Health and Science University Stress is a basic fact of life. In its broadest sense, it can be conceived of as any environmental event challenging homeostasis. Developing effective means for coping with stress, in many ways, differentiates successful from unsuccessful species. A dominant "stress response" in man is the activation of the hypothalamic-pituitary-adrenal axis. The humoral concomitants to this response are complex and not well characterized. Key elements include hypothalamic stimulatory secretogogues, CRH and anti-diuretic hormone, the hypothalamic inhibitory secretogogues, endogenous opiates, somatostatin, the natriuretic peptides, and oxytocin, POMC and its products, ACTH, MSH, and beta- endorphin; and the products of adrenal secretion, primarily cortisol in the human being. How these molecules orchestrate the HPA response to stress and the nature of the beneficial effects of this phenomenon are poorly understood. More clearly understood are the "stress-related disorders"' reproductive failure in adults and retarded growth in children. Since both of these abnormalities can be consequences of glucocorticoid excess, it is tempting to speculate that it is the cortisol component of the stress response that is responsible for these adverse effects. This proposal will use the cortisol production rate as a marker for stress and examine the hypothesis that chronic stress plays an important etiologic role in many cases of "idiopathic" infertility in adults and "idiopathic" growth retardation in children. The cortisol production rate will be measured with a new techniques using a deuterated cortisol infusion followed by the measurement of plasma cortisol "isotope enrichment" by LC-mass spectroscopy. The techniques is without radiation hazard and safe for women and children. Groups of patients bridging the spectrum from mild to severe stress will be studied in each category, as will their responses to therapeutic intervention. The results of this study should shed new light on the pathophysiology of "stress-related" disorders, and may indicate new avenues for diagnosis and treatment. |
0.923 |
| 1995 — 2002 | Loriaux, D Lynn | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Role of Stress in the Etiology of Idiopathic Infertility and Short Stature @ Oregon Health and Science University Untoward effects of glucocorticoid administration include attenuated linear growth, infertility, and miscarriage. We hypothesize that increased cortisol production associated with "stress" can lead to the same consequences. We propose testing this hypothesis by measuring cortisol production rates in appropriate subjects. |
0.923 |
| 2004 | Loriaux, D Lynn | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
A Study of Cortisol Production and Glucocorticoid Receptor Binding in Ptsd @ Oregon Health and Science University posttraumatic stress disorder; stress; corticosteroid receptors; cortisol; receptor binding; saliva; plasma; liquid chromatography mass spectrometry; human subject; clinical research; |
0.923 |