Farhan Mohammad

Affiliations:

Duke-NUS Graduate Medical School, Singapore, Singapore, Singapore

Area:

Optogenetics, Behavioral Neurogenetics, Disease Modelling, Neural-Circuit

Google:

"https://scholar.google.com.sg/citations?user=f_7ggSUAAAAJ&hl=en"

Bio:

RESEARCH INTEREST

I am interested in genes and neural circuits involved in human neurodevelopment disorders. My ongoing research is to understand how pleasure and aversion are encoded in neural circuitries. I have a particular interest in role of monoamines and their network effects on reward neural circuit. I employ optogenetic, molecular, neurogenetic, and imaging tools to select and manipulate specific neural circuits and study impact on animal behavior.

EDUCATION

The Institute of Genomics & Integrative Biology, Delhi, India 2003-2009
The Pune University, Maharashtra, India
Doctor of Philosophy in Biotechnology

The Jamia Hamdard, Delhi, India 2001-2003
Master of Science in Biotechnology

The Aligarh Muslim University, Aligarh, Uttar Pradesh, India 1998-2001
Bachelor of Science in Botany, Zoology & Chemistry

EXPERIENCE

Duke-NUS Medical School, Singapore 2018–Present
Senior Research Fellow

Duke-NUS Medical School, Singapore 2013–2017
Research Fellow

Neuroscience Research Partnership, A*STAR, Singapore 2011–2013
Research Fellow

University of Oxford, United Kingdom 2009-2010 Postdoctoral Fellow

TATA Institute of Fundamental Research (TIFR), Mumbai, India 2008-2009
Visiting Fellow

PUBLICATIONS

Optical inhibition of zebrafish behavior with anion channelrhodopsins
Gadisti Aisha Mohamed, Ruey Kuang Cheng, Joses Ho, Seetha Krishnan, Farhan Mohammad, Adam Claridge-Chang, & Suresh Jesuthasan
BMC Biology. 2017

Optogenetic inhibition of behavior with anion channelrhodopsins
Farhan Mohammad, James Stewart, Stanislav Ott, Katarina Chlebikova, Jia Yi Chua, Tong-Wey Koh, Joses Ho, & Adam Claridge-Chang
Nature methods. 2017
Highlighted by: The Medical News, MedicalXpress, EurekAlert and Medindia

Concordance and incongruence in preclinical anxiety models: systematic review and meta analyses
Farhan Mohammad, Joses Ho, Chun Lei Lim, Jia Hern Woo, Dennis Jun Jie Poon, Bhumika Lamba, & Adam Claridge-Chang
Neuroscience and Biobehavioral Reviews. 2016
Highlighted by: MedicalXpress

Ancient anxiety pathways influence Drosophila defense behaviors
Farhan Mohammad, Sameer Aryal, Joses Ho, James Charles Stewart, Nurul Ayuni Norman, Tan Teng Li, Agnese Eisaka & Adam Claridge-Chang
Current Biology. 2016
Highlighted by: Medical Daily, Asian Scientist, Science Daily, and EurekAlert.

Estimating information processing through a memory system: the utility of metaanalytic methods for genetics
Tugce ildizoglu, Jan-Marek Weislogel, Farhan Mohammad, Edwin S.-Y. Chan, Pryseley N. Assam, & Adam Claridge-Chang
PLoS Genetics. 2015

Genome wide DNA Methylation Profiling for Epigenetic Alteration in Coronary Artery Disease Patient.
Priyanka Sharmaa, Gaurav Garg, Arun Kumar, Farhan Mohammad, Sudha Ramesh Kumar, Vinay Singh Tanwar, Satish Sati, Abhay Sharma, Ganesan Karthikeyan, Vani Brahmachari
Gene. 2014

Transcriptomic Analysis in a Drosophila Model Identifies Previously Implicated and Novel Pathways in the Therapeutic Mechanism in Neuropsychiatric Disorders.
Priyanka Singh, Farhan Mohammad, & Abhay Sharma.
Front Neurosci. 2011

Gender Differences in a Drosophila Transcriptomic Model of Chronic Pentylenetetrazole Induced Behavioral Deficit.
Abhay Sharma, Farhan Mohammad, & Priyanka Singh.
PlosOne. 2009
Monoaminergic Regulation of Sonic Hedgehog Signaling Cascade Expression in the Adult Rat Hippocampus
Rajeev Rajendran, Shanker Jha, Kimberly A. Fernandes, Sunayana B. Banerjee, Farhan Mohammad, Brian G. Dias, & Vidita A. Vaidya
Neurosci Lett. 2009

A Drosophila Systems Model of Pentylenetetrazole Induced Locomotor Plasticity Responsive to Antiepileptic Drugs
Farhan Mohammad, Priyanka Singh, & Abhay Sharma
BMC Syst Biol. 2009

Whole Genome Expression and Biochemical Correlates of Extreme Constitutional Types Defined in Ayurveda
Bhavana Prasher, Sapna Negi, Shilpi Aggarwal, Amit K Mandal, Tav P Sethi, Shailaja R Deshmukh, Sudha G Purohit, Shantanu Sengupta, Sangeeta Khanna, Farhan Mohammad, Gaurav Garg, Samir K Brahmachari, Indian Genome Variation Consortium1 & Mitali Mukerji
J Transl Med. 2008

Genome-wide Computational and Expression Analyses Reveal G4 quadruplex DNA Motifs as Conserved Cis‑Regulatory Elements in Human and Related species
Anjali Verma, Kangkan Halder, Rashi Halder, Vinod Kumar Yadav, Pooja Rawat, Ram Krishna Thakur, Farhan Mohd, Abhay Sharma & Shantanu Chowdhury
J. Med. Chem. 2008

PAPERS IN PROGRESS

Dopamine neurons control a D2-dependent speed–choice transition between attraction and aversion
Farhan Mohammad, Joses Ho, Xianyuan Zhang, James Charles Stewart, Stanislav Ott, Tayfun Tumkaya, Mashiur Rahman, and Adam Claridge-Chang

A zinc-finger fusion protein refines Gal4-defined neural circuits
Shamprasad Varija Raghu*, Farhan Mohammad*, Chua Jia Yi, Claudia S. Barros, Joanne Lam, Mavis Loberas, Sadhna Sahani and Adam Claridg-Chang (* Equal Authorship)

The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors
Joel Selkrig*, Farhan Mohammad*, Soon Hwee Ng , Chua Jia Yi, Tayfun Tumkaya ,Joses Ho, Yin Ning Chiang , Dirk Rieger, Sven Pettersson, Charlotte Helfrich-Förster, Joanne Y. Yew, Adam Claridge-Chang
(* Equal Authorship)

FELLOWSHIPS AND AWARDS

Council of Scientific & Industrial Research (CSIR), India 2003-2006
Junior Research Fellowship

Council of Scientific & Industrial Research (CSIR), India 2006-2008
Senior Research Fellowship

Duke-NUS Early Career Scientists Association 2013
Best Poster in Neuroscience Award

Duke-NUS Early Career Scientists Association 2016
Best Poster in Neuroscience Award

SEMINARS AND LECTURES

Frontiers in Mental Health Symposium (FMHS), Singapore Mar 2018

The Department of Molecular Biology and Genetics, Oct 2017
Boğaziçi University, Istanbul, Turkey

Inter-Program Seminar, Duke-NUS Medical School Feb 2017

Janelia Genetic Manipulations of Neuronal Activity IV, U.S.A. Oct 2016
EMBO-Kavli Drosophila Neural Circuits Workshop, Crete, Greece Jul 2015

IMCB Seminar series, Singapore Jul 2014

CELL SYMPOSIA: GENES, CIRCUITS & BEHAVIOR, Canada Jun 2013

Int. Conference of Neurons and Brain Diseases, Singapore Jun 2013

NEUROFLY Conference, Padova, Italy Sep 2012

SYMPOSIA, WORKSHOP AND CONTINUING EDUCATION

Making parts using CNC Machine, Singapore Sep 2017

Gopen Scientific Writing Course, Duke-NUS, Singapore Mar 2017

ETC Drug Discovery Course, A-STAR, Singapore Aug 2016

Virtual Fly Brain Behavior Workshop, Crete, Greece Jul 2015

Essential English, Duke-NUS, Singapore Apr 2014

Writing the Scientific Manuscript, Singapore Mar 2013

Solidworks CAD Software Essential Training, Singapore Mar 2012

MATLAB Statistical, Singapore Feb 2012

Scientific Presentation Skills (SPS), A-STAR, Singapore Feb 2012
Understanding the Mind Symposium, Singapore Dec 2011

Comprehensive MATLAB Training, Singapore Nov 2011

Python for Scientists and Engineers, Singapore Oct 2011
MENTORING

Student Mentoring Role Institution Start End
Zhang Xianyuan PhD thesis NUS Pharmacology 05/15 now
Tayfun Tümkaya PhD thesis Duke-NUS Med Sch 08/14 now
Sinem Kadaoğlu SIPGA Awardee Istanbul Tech. Uni 04/18 now
Quyen Bao Do ASTAR Scholar Imperial College 07/17 now
Siti Binte Mutaza FYP/Internship NTU Biology 01/17 01/18
Shawn Tan Yi Han FYP/Internship Temasek Polytechnic 09/16 01/17
Safwan Burhanudin FYP/Internship Final Year Project 09/16 01/17
Helen Whitley Undergraduate Oxford University 08/16 11/16
Matthew Woo Jia Hern FYP/Internship Temasek Polytechnic 09/15 08/16
Shanice Lim Chun Lei FYP/Internship Temasek Polytechnic 09/15 01/16
Dennis Poon Jun Jie Undergraduate NTU Biology 06/15 08/15
Marilyn Ho Qiao Lin Undergraduate NTU Biology 06/15 08/15
Bhumika Lamba Undergraduate NUS Bioengineering 06/15 08/15
Nurul Ayuni Bte Norman FYP/Internship Temasek Polytechnic 09/14 06/15
Daniel Koh Shi Wei FYP/Internship Temasek Polytechnic 09/14 06/15
Heena Ramesh Vasnani FYP/Internship Temasek Polytechnic 09/14 06/15
Lim Kim Loong Graduate Intern Uni. of Queensland 10/14 12/14
Taarini Arrikath Undergraduate UC San Diego 06/14 08/14
Katarina Chlebikova SIPGA Awardee Cambridge Uni 06/13 08/14
Cai Na Graduate Intern Cambridge Uni 06/11 08/11
Madeline Tan FYP/Internship Temasek Polytechnic 09/13 01/14
Sameer Aryal SIPGA Awardee Williams College 08/12 06/13
Christy Tan Teng Li FYP/Internship Temasek Polytechnic 09/12 05/13
Shankar Chandrashekar Graduate Intern Anna University 09/12 01/13
Lim Jing Xuan ASTAR Scholar A*STAR 06/11 08/11
Agnese Eisaka SIPGA Awardee Trinity College 06/11 08/11
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