Juan P. Cueva, Ph.D.

Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Dopamine and Serotonin Agonists
"Juan Cueva"
Mean distance: 18.16 (cluster 11)


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David E. Nichols grad student 2008 Purdue
 (Inquiry into the structural and conformational requirements of beta-phenyldopamine-type ligands for selective dopamine D1 receptor activation.)
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Juncosa JI, Hansen M, Bonner LA, et al. (2013) Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. Acs Chemical Neuroscience. 4: 96-109
Cueva JP, Chemel BR, Juncosa JI, et al. (2012) Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European Journal of Medicinal Chemistry. 48: 97-107
Cueva JP, Gallardo-Godoy A, Juncosa JI, et al. (2011) Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of Medicinal Chemistry. 54: 5508-21
Clark LH, Cueva JP, McCorvy JD, et al. (2011) C-Ring expanded analogs of doxanthrine: Conformation plays a critical role Arkivoc. 2010: 125-138
Przybyla JA, Cueva JP, Chemel BR, et al. (2009) Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46
Cueva JP, Nichols DE. (2009) A novel and efficient synthesis of dihydrexidine Synthesis. 715-720
Cueva JP, Giorgioni G, Grubbs RA, et al. (2006) trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. Journal of Medicinal Chemistry. 49: 6848-57
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