| Year |
Citation |
Score |
| 2015 |
Cueva JP, Roche C, Ostovar M, Kumar V, Clark MJ, Hillhouse TM, Lewis JW, Traynor JR, Husbands SM. C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors. Journal of Medicinal Chemistry. 58: 4242-9. PMID 25898137 DOI: 10.1021/Acs.Jmedchem.5B00130 |
0.335 |
|
| 2014 |
Kormos CM, Cueva JP, Gichinga MG, Runyon SP, Thomas JB, Brieaddy LE, Mascarella SW, Gilmour BP, Navarro HA, Carroll FI. Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines. Journal of Medicinal Chemistry. 57: 3140-7. PMID 24635568 DOI: 10.1021/Jm500184J |
0.428 |
|
| 2013 |
Kormos CM, Jin C, Cueva JP, Runyon SP, Thomas JB, Brieaddy LE, Mascarella SW, Navarro HA, Gilmour BP, Carroll FI. Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists. Journal of Medicinal Chemistry. 56: 4551-67. PMID 23651437 DOI: 10.1021/Jm400275H |
0.539 |
|
| 2013 |
Juncosa JI, Hansen M, Bonner LA, Cueva JP, Maglathlin R, McCorvy JD, Marona-Lewicka D, Lill MA, Nichols DE. Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. Acs Chemical Neuroscience. 4: 96-109. PMID 23336049 DOI: 10.1021/Cn3000668 |
0.719 |
|
| 2012 |
Cueva JP, Chemel BR, Juncosa JI, Lill MA, Watts VJ, Nichols DE. Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European Journal of Medicinal Chemistry. 48: 97-107. PMID 22204903 DOI: 10.1016/J.Ejmech.2011.11.039 |
0.727 |
|
| 2011 |
Cueva JP, Gallardo-Godoy A, Juncosa JI, Vidi PA, Lill MA, Watts VJ, Nichols DE. Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of Medicinal Chemistry. 54: 5508-21. PMID 21714510 DOI: 10.1021/Jm200334C |
0.768 |
|
| 2011 |
Clark LH, Cueva JP, McCorvy JD, Harland AA, Watts VJ, Nichols DE. C-Ring expanded analogs of doxanthrine: Conformation plays a critical role Arkivoc. 2010: 125-138. DOI: 10.3998/Ark.5550190.0011.411 |
0.819 |
|
| 2010 |
Carroll FI, Cueva JP, Thomas JB, Mascarella SW, Runyon SP, Navarro HA. 1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists. Acs Medicinal Chemistry Letters. 1: 365-369. PMID 21116435 DOI: 10.1021/ml100126b |
0.443 |
|
| 2009 |
Cueva JP, Cai TB, Mascarella SW, Thomas JB, Navarro HA, Carroll FI. Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Journal of Medicinal Chemistry. 52: 7463-72. PMID 19954245 DOI: 10.1021/Jm900756T |
0.435 |
|
| 2009 |
Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ, McCorvy JD, Chester JA, Nichols DE, Watts VJ. Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46. PMID 19028082 DOI: 10.1016/J.Euroneuro.2008.10.002 |
0.772 |
|
| 2009 |
Cueva JP, Nichols DE. A novel and efficient synthesis of dihydrexidine Synthesis. 715-720. DOI: 10.1055/S-0028-1083359 |
0.649 |
|
| 2006 |
Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE. trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. Journal of Medicinal Chemistry. 49: 6848-57. PMID 17154515 DOI: 10.1021/Jm0604979 |
0.652 |
|
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