A Claudio Cuello, OC, MD, DSc, FRSC, FMedSci, FMedSci

Affiliations: 
1985- Pharmacology And Therapeutics McGill University, Montreal, QC, Canada 
Area:
Alzheimer's Disease, cognitive behavior, neurochemistry, immunocytochemistry, neuropharmacology and molecular biology.
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"A Claudio Cuello"
Bio:

Since 2003, he has been the Charles E. Frosst/Merck endowed Chair in Pharmacology at McGill University. He leads a research team on multidisciplinary aspects (cognitive behavior, neurochemistry, immunocytochemistry, neuropharmacology and molecular biology) of brain aging and Alzheimer’s disease neuropathology. The Cuello Lab is comprised of talented and motivated colleagues focused on unravelling the earliest biochemical-pathological events of the Alzheimer’s pathology as well as searching for early biomarkers and novel experimental therapies to arrest or revert the early Alzheimer’s pathology. His group has recently made important contributions to the understanding of CNS trophic factor deregulation both in Alzheimer’s disease and in Down syndrome.

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Mean distance: 13.39 (cluster 11)
 
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Publications

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Navas Guimaraes ME, Lopez-Blanco R, Correa J, et al. (2021) Liver X Receptor Activation with an Intranasal Polymer Therapeutic Prevents Cognitive Decline without Altering Lipid Levels. Acs Nano
Habif M, Do Carmo S, Báez MV, et al. (2020) Early Long-Term Memory Impairment and Changes in the Expression of Synaptic Plasticity-Associated Genes, in the McGill-R-Thy1-APP Rat Model of Alzheimer's-Like Brain Amyloidosis. Frontiers in Aging Neuroscience. 12: 585873
Pentz R, Iulita MF, Ducatenzeiler A, et al. (2020) Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Flores-Aguilar L, Iulita MF, Kovecses O, et al. (2020) Evolution of neuroinflammation across the lifespan of individuals with Down syndrome. Brain : a Journal of Neurology
Pentz R, Iulita MF, Mikutra-Cencora M, et al. (2020) A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology. Neurobiology of Disease. 105150
Kang MS, Aliaga AA, Shin M, et al. (2020) Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease. Molecular Psychiatry
Pentz R, Iulita MF, Ducatenzeiler A, et al. (2020) The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease. Molecular Psychiatry
Hampel H, Vergallo A, Caraci F, et al. (2020) Future avenues for Alzheimer's disease detection and therapy: Liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery. Neuropharmacology. 108081
Hampel H, Caraci F, Cuello AC, et al. (2020) A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease. Frontiers in Immunology. 11: 456
Welikovitch LA, Do Carmo S, Maglóczky Z, et al. (2020) Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain. Proceedings of the National Academy of Sciences of the United States of America
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