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A Claudio Cuello, OC, MD, DSc, FRSC, FMedSci, FMedSci

Affiliations: 
1985- Pharmacology And Therapeutics McGill University, Montreal, QC, Canada 
Area:
Alzheimer's Disease, cognitive behavior, neurochemistry, immunocytochemistry, neuropharmacology and molecular biology.
Google:
"A Claudio Cuello"
Bio:

Since 2003, he has been the Charles E. Frosst/Merck endowed Chair in Pharmacology at McGill University. He leads a research team on multidisciplinary aspects (cognitive behavior, neurochemistry, immunocytochemistry, neuropharmacology and molecular biology) of brain aging and Alzheimer’s disease neuropathology. The Cuello Lab is comprised of talented and motivated colleagues focused on unravelling the earliest biochemical-pathological events of the Alzheimer’s pathology as well as searching for early biomarkers and novel experimental therapies to arrest or revert the early Alzheimer’s pathology. His group has recently made important contributions to the understanding of CNS trophic factor deregulation both in Alzheimer’s disease and in Down syndrome.

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Parents

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Amanda Pellegrino de Iraldi grad student Universidad de Buenos Aires
Eduardo De Robertis grad student UBA
William Francis Ganong post-doc UCSF (Physiology Academic Tree)
Leslie Iversen post-doc Cambridge
Fernando Orioli post-doc Universidad de Buenos Aires
Umberto Tramezzani post-doc IBYME-CONICET Buenos Aires

Children

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Lisi Flores Aguilar grad student McGill
John V. Priestley grad student Oxford
Michael V. Sofroniew grad student Johns Hopkins, McGill University
Morgan Foret grad student 2015- McGill
Tak Pan Wong grad student 1995-2001 McGill
Maria T. Ferretti grad student 2012 McGill
Edward Nesbitt Wilson grad student 2011-2016 McGill University School of Medicine
Lindsay A. Welikovitch grad student 2014-2020 McGill
Joshua T Emmerson grad student 2017-2023 McGill
Alfredo Ribeiro-da-Silva post-doc McGill
Valentina Echeverria Moran post-doc 2001-2003 McGill
Valentina Echeverria Moran post-doc 2001-2003 McGill University School of Medicine
Sonia Do Carmo research scientist 2010- McGill

Collaborators

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Publications

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Emmerson JT, Do Carmo S, Lavagna A, et al. (2024) Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model. Acta Neuropathologica Communications. 12: 193
Do Carmo S, Kautzmann MI, Bhattacharjee S, et al. (2024) Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology. Journal of Neuroinflammation. 21: 185
Foret MK, Orciani C, Welikovitch LA, et al. (2024) Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model. Communications Biology. 7: 861
Piza DB, Corrigan BW, Gulli RA, et al. (2024) Primacy of vision shapes behavioral strategies and neural substrates of spatial navigation in marmoset hippocampus. Nature Communications. 15: 4053
Galeano P, de Ceglia M, Mastrogiovanni M, et al. (2023) The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis. International Journal of Molecular Sciences. 24
Orciani C, Do Carmo S, Foret MK, et al. (2023) Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology. Neurobiology of Aging. 132: 220-232
Emmerson JT, Malcolm JC, Do Carmo S, et al. (2023) Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy. Neurobiology of Disease. 187: 106317
Emmerson JT, Do Carmo S, Liu Y, et al. (2023) Corrigendum to "Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model" [Neurobiol of Disease 184 (2023),106227 / YNBDI_106227]. Neurobiology of Disease. 187: 106301
Emmerson JT, Do Carmo S, Liu Y, et al. (2023) Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model. Neurobiology of Disease. 106227
Dalmasso MC, Arán M, Galeano P, et al. (2023) Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics. Frontiers in Molecular Biosciences. 9: 1067296
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