Tija Jacob
Affiliations: | Neurobiology | University of Pennsylvania, Philadelphia, PA, United States | |
| Neuroscience | Tufts University Sackler School of Biomedical Research | ||
| Pharmacology | University of Pittsburgh School of Medicine, Pittsburgh, PA, United States |
Area:
GABA A receptor trafficking, circuit developmentWebsite:
http://www.pitt.edu/~jacoblab/Jacobhome.htmlGoogle:
"Tija Jacob"Mean distance: 14.98 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| Joshua M. Kaplan | grad student | 2002 | UC Berkeley | |
| (Neuropeptide modulation of Caenorhabditis elegans behavior.) | ||||
| Stephen J. Moss | post-doc | Penn | ||
Children
Sign in to add trainee| Jessica L. Nuwer | post-doc | 2020- | University of Pittsburgh School of Medicine |
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Publications
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| Lorenz-Guertin JM, Povysheva N, Chapman CA, et al. (2023) Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain. Neurobiology of Disease. 106248 |
| Nuwer JL, Povysheva N, Jacob TC. (2023) Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition. Neuropharmacology. 237: 109587 |
| Chapman CA, Nuwer JL, Jacob TC. (2022) The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms. Frontiers in Synaptic Neuroscience. 14: 911020 |
| Nuwer JL, Brady ML, Povysheva NV, et al. (2021) Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission. Neuropharmacology. 108724 |
| Lombardi JP, Kinzlmaier DA, Jacob TC. (2020) Visualizing GABA A Receptor Trafficking Dynamics with Fluorogenic Protein Labeling. Current Protocols in Neuroscience. 92: e97 |
| Jacob TC. (2019) Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors. Frontiers in Molecular Neuroscience. 12: 179 |
| Lorenz-Guertin JM, Bambino MJ, Das S, et al. (2019) Diazepam Accelerates GABAR Synaptic Exchange and Alters Intracellular Trafficking. Frontiers in Cellular Neuroscience. 13: 163 |
| Brady ML, Pilli J, Lorenz-Guertin JM, et al. (2017) Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling. Neuropharmacology |
| Lorenz-Guertin JM, Wilcox MR, Zhang M, et al. (2017) A versatile optical tool for studying synaptic GABAA receptor trafficking. Journal of Cell Science |
| Lorenz-Guertin JM, Jacob TC. (2017) GABA type A receptor trafficking and the architecture of synaptic inhibition. Developmental Neurobiology |