Tija Jacob

Affiliations: 
Neurobiology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience Tufts University Sackler School of Biomedical Research 
 Pharmacology University of Pittsburgh School of Medicine, Pittsburgh, PA, United States 
Area:
GABA A receptor trafficking, circuit development
Website:
http://www.pitt.edu/~jacoblab/Jacobhome.html
Google:
"Tija Jacob"
Mean distance: 14.98 (cluster 11)
 
SNBCP

Parents

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Joshua M. Kaplan grad student 2002 UC Berkeley
 (Neuropeptide modulation of Caenorhabditis elegans behavior.)
Stephen J. Moss post-doc Penn
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Publications

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Brady ML, Jacob TC. (2015) Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation. Developmental Neurobiology
Petrini EM, Ravasenga T, Hausrat TJ, et al. (2014) Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Nature Communications. 5: 3921
Brady ML, Moon CE, Jacob TC. (2014) Using an α-bungarotoxin binding site tag to study GABA A receptor membrane localization and trafficking. Journal of Visualized Experiments : Jove
Jacob TC, Michels G, Silayeva L, et al. (2012) Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibition. Proceedings of the National Academy of Sciences of the United States of America. 109: 18595-600
Jacob TC, Wan Q, Vithlani M, et al. (2009) GABA(A) receptor membrane trafficking regulates spine maturity. Proceedings of the National Academy of Sciences of the United States of America. 106: 12500-5
Jacob TC, Moss SJ, Jurd R. (2008) GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nature Reviews. Neuroscience. 9: 331-43
Tretter V, Jacob TC, Mukherjee J, et al. (2008) The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1356-65
Saliba RS, Michels G, Jacob TC, et al. (2007) Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13341-51
Jacob TC, Bogdanov YD, Magnus C, et al. (2005) Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10469-78
Jacob TC, Kaplan JM. (2003) The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2122-30
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