Tija Jacob

Neurobiology University of Pennsylvania, Philadelphia, PA, United States 
 Neuroscience Tufts University Sackler School of Biomedical Research 
 Pharmacology University of Pittsburgh School of Medicine, Pittsburgh, PA, United States 
GABA A receptor trafficking, circuit development
"Tija Jacob"
Mean distance: 14.98 (cluster 11)


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Joshua M. Kaplan grad student 2002 UC Berkeley
 (Neuropeptide modulation of Caenorhabditis elegans behavior.)
Stephen J. Moss post-doc Penn
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Lorenz-Guertin JM, Povysheva N, Chapman CA, et al. (2023) Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain. Neurobiology of Disease. 106248
Nuwer JL, Povysheva N, Jacob TC. (2023) Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition. Neuropharmacology. 237: 109587
Chapman CA, Nuwer JL, Jacob TC. (2022) The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms. Frontiers in Synaptic Neuroscience. 14: 911020
Nuwer JL, Brady ML, Povysheva NV, et al. (2021) Sustained treatment with an α5 GABA A receptor negative allosteric modulator delays excitatory circuit development while maintaining GABAergic neurotransmission. Neuropharmacology. 108724
Lombardi JP, Kinzlmaier DA, Jacob TC. (2020) Visualizing GABA A Receptor Trafficking Dynamics with Fluorogenic Protein Labeling. Current Protocols in Neuroscience. 92: e97
Jacob TC. (2019) Neurobiology and Therapeutic Potential of α5-GABA Type A Receptors. Frontiers in Molecular Neuroscience. 12: 179
Lorenz-Guertin JM, Bambino MJ, Das S, et al. (2019) Diazepam Accelerates GABAR Synaptic Exchange and Alters Intracellular Trafficking. Frontiers in Cellular Neuroscience. 13: 163
Brady ML, Pilli J, Lorenz-Guertin JM, et al. (2017) Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling. Neuropharmacology
Lorenz-Guertin JM, Wilcox MR, Zhang M, et al. (2017) A versatile optical tool for studying synaptic GABAA receptor trafficking. Journal of Cell Science
Lorenz-Guertin JM, Jacob TC. (2017) GABA type A receptor trafficking and the architecture of synaptic inhibition. Developmental Neurobiology
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