Gregory C. Adam, Ph.D.
Affiliations: | 2003 | Scripps Research Institute, La Jolla, La Jolla, CA, United States |
Area:
Medicinal ChemistryGoogle:
"Gregory Adam"Mean distance: 18.87 | S | N | B | C | P |
Parents
Sign in to add mentor| Benjamin F. Cravatt | grad student | 2003 | Scripps Institute | |
| (A non-directed strategy to activity-based protein profiling.) | ||||
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Publications
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| Li X, Chandra D, Letarte S, et al. (2021) Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling. Analytical Chemistry |
| Bukhtiyarova M, Cook EM, Hancock PJ, et al. (2021) Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen. Acs Medicinal Chemistry Letters. 12: 99-106 |
| Petrilli WL, Adam GC, Erdmann RS, et al. (2019) From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chemical Biology |
| Burlein C, Wang C, Min X, et al. (2017) Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity. Acs Chemical Biology |
| Santa Maria JP, Park Y, Yang L, et al. (2017) Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase. Acs Chemical Biology |
| Painter RE, Adam GC, Arocho M, et al. (2015) Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin. Chemistry & Biology |
| Meng J, Lai MT, Munshi V, et al. (2015) Screening of HIV-1 Protease Using a Combination of an Ultra-High-Throughput Fluorescent-Based Assay and RapidFire Mass Spectrometry. Journal of Biomolecular Screening. 20: 606-15 |
| Adam GC, Meng J, Rizzo JM, et al. (2015) Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens. Journal of Biomolecular Screening. 20: 212-22 |
| Vachal P, Miao S, Pierce JM, et al. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. Journal of Medicinal Chemistry. 55: 2945-59 |
| Adam GC, Parish CA, Wisniewski D, et al. (2008) Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase. Journal of the American Chemical Society. 130: 16704-10 |