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Gregory C. Adam, Ph.D. - Publications

Affiliations: 
2003 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Medicinal Chemistry
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li X, Chandra D, Letarte S, Adam GC, Welch J, Yang RS, Rivera S, Bodea S, Dow A, Chi A, Strulson CA, Richardson DD. Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling. Analytical Chemistry. PMID 34032423 DOI: 10.1021/acs.analchem.1c00042  0.438
2021 Bukhtiyarova M, Cook EM, Hancock PJ, Hruza AW, Shaw AW, Adam GC, Barnard RJO, McKenna PM, Holloway MK, Bell IM, Carroll S, Cornella-Taracido I, Cox CD, Kutchukian PS, Powell DA, et al. Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen. Acs Medicinal Chemistry Letters. 12: 99-106. PMID 33488970 DOI: 10.1021/acsmedchemlett.0c00551  0.311
2019 Petrilli WL, Adam GC, Erdmann RS, Abeywickrema P, Agnani V, Ai X, Baysarowich J, Byrne N, Caldwell JP, Chang W, DiNunzio E, Feng Z, Ford R, Ha S, Huang Y, et al. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chemical Biology. PMID 31653597 DOI: 10.1016/J.Chembiol.2019.10.002  0.397
2017 Burlein C, Wang C, Min X, Bhatt T, Stahlhut M, Ou Y, Adam GC, Heath J, Klein DJ, Sanders J, Narayan K, Abeywickrema P, Heo MR, Carroll SS, Grobler JA, et al. Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity. Acs Chemical Biology. PMID 29024587 DOI: 10.1021/Acschembio.7B00550  0.387
2017 Santa Maria JP, Park Y, Yang L, Murgolo N, Altman MD, Zuck P, Adam G, Chamberlin C, Saradjian P, Dandliker P, Boshoff HIM, Barry CE, Garlisi C, Olsen DB, Young K, et al. Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase. Acs Chemical Biology. PMID 28806050 DOI: 10.1021/Acschembio.7B00468  0.392
2015 Painter RE, Adam GC, Arocho M, DiNunzio E, Donald RG, Dorso K, Genilloud O, Gill C, Goetz M, Hairston NN, Murgolo N, Nare B, Olsen DB, Powles M, Racine F, et al. Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin. Chemistry & Biology. PMID 26456734 DOI: 10.1016/J.Chembiol.2015.08.015  0.396
2015 Meng J, Lai MT, Munshi V, Grobler J, McCauley J, Zuck P, Johnson EN, Uebele VN, Hermes JD, Adam GC. Screening of HIV-1 Protease Using a Combination of an Ultra-High-Throughput Fluorescent-Based Assay and RapidFire Mass Spectrometry. Journal of Biomolecular Screening. 20: 606-15. PMID 25681434 DOI: 10.1177/1087057115570838  0.404
2015 Adam GC, Meng J, Rizzo JM, Amoss A, Lusen JW, Patel A, Riley D, Hunt R, Zuck P, Johnson EN, Uebele VN, Hermes JD. Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens. Journal of Biomolecular Screening. 20: 212-22. PMID 25336354 DOI: 10.1177/1087057114555832  0.401
2012 Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R, Gollapudi A, Keohane CA, Lingham RB, Mandala SM, DeMartino JA, ... ... Adam G, et al. 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. Journal of Medicinal Chemistry. 55: 2945-59. PMID 22364528 DOI: 10.1021/Jm201542D  0.434
2008 Adam GC, Parish CA, Wisniewski D, Meng J, Liu M, Calati K, Stein BD, Athanasopoulos J, Liberator P, Roemer T, Harris G, Chapman KT. Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase. Journal of the American Chemical Society. 130: 16704-10. PMID 19049464 DOI: 10.1021/Ja805531W  0.397
2007 Adam GC, Meng J, Athanasopoulos J, Zhang X, Chapman KT. Affinity-based ranking of ligands for DPP-4 from mixtures. Bioorganic & Medicinal Chemistry Letters. 17: 2404-7. PMID 17337342 DOI: 10.1016/J.Bmcl.2007.02.040  0.45
2004 Adam GC, Burbaum J, Kozarich JW, Patricelli MP, Cravatt BF. Mapping enzyme active sites in complex proteomes. Journal of the American Chemical Society. 126: 1363-8. PMID 14759193 DOI: 10.1021/Ja038441G  0.645
2003 Adam GC, Vanderwal CD, Sorensen EJ, Cravatt BF. (-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1. Angewandte Chemie (International Ed. in English). 42: 5480-4. PMID 14618582 DOI: 10.1002/Anie.200352576  0.459
2003 Speers AE, Adam GC, Cravatt BF. Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. Journal of the American Chemical Society. 125: 4686-7. PMID 12696868 DOI: 10.1021/Ja034490H  0.634
2002 Adam GC, Sorensen EJ, Cravatt BF. Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes. Molecular & Cellular Proteomics : McP. 1: 828-835. PMID 12438565 DOI: 10.1074/Mcp.T200007-Mcp200  0.617
2002 Adam GC, Sorensen EJ, Cravatt BF. Chemical strategies for functional proteomics. Molecular & Cellular Proteomics : McP. 1: 781-790. PMID 12438561 DOI: 10.1074/Mcp.R200006-Mcp200  0.581
2002 Adam GC, Sorensen EJ, Cravatt BF. Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype Nature Biotechnology. 20: 805-809. PMID 12091914 DOI: 10.1038/Nbt714  0.642
2001 Adam GC, Cravatt BF, Sorensen EJ. Profiling the specific reactivity of the proteome with non-directed activity-based probes Chemistry and Biology. 8: 81-95. PMID 11182321 DOI: 10.1016/S1074-5521(00)90060-7  0.638
2000 Buynak JD, Doppalapudi VR, Adam G. The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as β-lactamase inhibitors Bioorganic and Medicinal Chemistry Letters. 10: 853-857. PMID 10853646 DOI: 10.1016/S0960-894X(00)00098-6  0.395
1999 Buynak JD, A Srinivasa R, Doppalapudi VR, Adam G, Petersen PJ, Nidamarthy SD. The synthesis and evaluation of 6-alkylidene-2'β-substituted penam sulfones as β-lactamase inhibitors Bioorganic and Medicinal Chemistry Letters. 9: 1997-2002. PMID 10450969 DOI: 10.1016/S0960-894X(99)00325-X  0.309
1997 Buynak JD, Srinivasa Rao A, Ford GP, Carver C, Adam G, Geng B, Bachmann B, Shobassy S, Lackey S. 7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase Journal of Medicinal Chemistry. 40: 3423-3433. PMID 9341917 DOI: 10.1021/Jm970351X  0.416
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