Kui K. Chan, Ph.D.
Affiliations: | 2006 | University of Illinois, Urbana-Champaign, Urbana-Champaign, IL |
Area:
structure/function relationships for enzyme-catalyzed reactionsGoogle:
"Kui Chan"Mean distance: 8.78 | S | N | B | C | P |
Parents
Sign in to add mentor| John A. Gerlt | grad student | 2006 | UIUC | |
| (Investigation of substrate specificity in phosphate binding barrels and mechanistic studies of orotidine monophosphate decarboxylase.) | ||||
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Publications
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| Toth K, Amyes TL, Wood BM, et al. (2010) Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. Journal of the American Chemical Society. 132: 7018-24 |
| Toth K, Amyes TL, Wood BM, et al. (2009) An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. Biochemistry. 48: 8006-13 |
| Chan KK, Wood BM, Fedorov AA, et al. (2009) Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Evidence for substrate destabilization Biochemistry. 48: 5518-5531 |
| Wood BM, Chan KK, Amyes TL, et al. (2009) Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Effect of solvent viscosity on kinetic constants Biochemistry. 48: 5510-5517 |
| Chan KK, Fedorov AA, Fedorov EV, et al. (2008) Structural basis for substrate specificity in phosphate binding (β/α)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12 Biochemistry. 47: 9608-9617 |
| Amyes TL, Wood BM, Chan K, et al. (2008) Formation and stability of a vinyl carbanion at the active site of orotidine 5′-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP Journal of the American Chemical Society. 130: 1574-1575 |
| Toth K, Amyes TL, Wood BM, et al. (2007) Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. Journal of the American Chemical Society. 129: 12946-7 |